Post on 22-Jul-2016
description
2
Therapeu*c Drug Monitoring (TDM)
Today:
[1] Edurant (Rilpivirine) prescribing informa*on
???
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Today:
[1] Edurant (Rilpivirine) prescribing informa*on
0 6 1 2 1 8 2 4 3 0 3 6
1 0
1 0 0
1 0 0 0
T im e a f te r d o s e [H o u rs ]
Rilp
ivir
ine
Co
nc
en
tra
tio
ns
(ng
/m
L)
Target Cmin=44ng/mL
Cmin < 44ng/mL for 40% of popula;on !
TDM of Rilpivirine (an*retroviral drug)
35 000 000 HIV+ 6300 new infec;on/day
4
Today: Tomorrow:
Therapeu*c Drug Monitoring (TDM)
ü automated ü personalized
5
Population-based percentiles
Individual concentration vs time profile dosing schedule suggestion
ü Predic*on engine (Bayesian approach) ü Ergonomic soHware
6
DBMS, remote data collection
Easy to integrate (Health Level 7 interface)
EzeCHiel light
Clinical interpretation (TDM) Drug developement
Clinical trials
Aggregation of data for the research
Ø Precision Ø Predic;on modeling Ø Time Ø Interoperability Ø Privacy & Security Ø U;lity Ø User-‐friendly
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Team
Dr. Séverine Pe;tprez, Drug models development
Alev;na Dubovitskaya, Data mining, Interoperability
Dr. Manel Aouri, Clinical evalua8on
Prof. T. Buclin, MD Dr. N. Widmer Prof. C. Csajka
A. Chaouch
Dr. M. Guidi
Advisory Board:
Dr. P. André
Prof. Y.Thoma
Y. Su]er R. Hooper
Prof. M. Schumacher
Division of Clinical Pharmacology, CHUV Development of drug models, clinical evalua8on
REDS HEIG-‐VD, HES-‐SO VS So;ware development, Interoperability
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Ac*on Plan
9
Ac*on Plan
1/09 Nano-Tera Meeting, Bern| 04 May, 2015
We sell Onsite H2 production system
which is cost effective, cleaner & greener, for fertilizer
and chemical industries
Ready to Launch
Solar Fuel, the smarter way.
SoHHytec
2/09 Nano-Tera Meeting, Bern| 04 May, 2015
Refineries 20%
Ammonia 53%
Other 20%
Methanol 7%
Our Customer
H2 Usage
Fertilizer and Chemical industries
3/09 Nano-Tera Meeting, Bern| 04 May, 2015
Problem worth solving:
On site cost effective H2 production using smart combination of concentrated solar energy during day and cheap grid electricity during night using our Integrated PEC device
Lack of cost effective onsite H2 production. 95% of current world H2 production comes from off-site steam reforming of conventional fossil fuels which is
Our Solution:
Not clean & non-renewable
Costly due to specialized transportation
Downscaling the size becomes extremely expensive
Faster degradation of the system
Cleaner & Greener
Highly scalable in size (up/down)
Onsite hence no costly expenses for transportation
Longer and durable life span
Our Opportunity
Lack of cost effective onsite H2
production
4/09 Nano-Tera Meeting, Bern| 04 May, 2015
Night Operation
Compressor
Storage
Concentrator
H2 O2
H2O
Cheap Grid Electricity
During night
CUSTOMER
PV+ELECTROLYZER
Our Product
Integrated PEC
Day Operation
5/09 Nano-Tera Meeting, Bern| 04 May, 2015
Case Operation Type Price
1 Our System 1.69 $/Kg Great combination of sunlight during day and cheap electricity during night
2 Just electrolysis using electricity (Day + Night)
2.21 $/Kg
Even just day electricity price during the lifespan makes it expensive option
3 Steam reforming requiring transportation
2 $/Kg Transportation alone increase price of hydrogen by 1$/kg* of H2 *Hydrogen Sta.on Compression, Storage, and Dispensing Technical Status and Costs ,G. Parks, R. Boyd, J. Cornish, and R. Remick , NREL Independent Peer Review Report
1 2 3
1.69 $
2.21 $ 2 $
Business Potential
Our H2 Production cost (without CSD) including 15% ROI
1.69 $/Kg
For 50m by 50m system producing 234 Kg H2/ day Exemplary case
6/09 Nano-Tera Meeting, Bern| 04 May, 2015
How we make Profit
Strategy: 15% ROI plus yearly charges equal to 50% of customer’s saving potential for next 15 years
day 1 year 1-10 year 10-15
54k $
132k $ 136k $
For the installation of the size of 50m by 50m with 360k $ investment
0
2
1 3 5 7 9 11 13 15 Years
Customer’s Saving potential Our profits
$/Kg
of H
2
Our system
Distributed steam reforming
7/09 Nano-Tera Meeting, Bern| 04 May, 2015
Meet our Team
Saurabh Tembhurne CEO and co-founder Doctoral Ass istant in ENERGY Laboratory of Renewable Energy Sc ience and Engineering (LRESE) EPFL, Lausanne
Meng Lin CTO and co-founder Doctoral Ass i s tant in ENERGY Laboratory of Renewable Energy Sc ience and Engineering (LRESE) EPFL, Lausanne
Prof. Sophia Haussener Scientific Advisor Assistant Professor Laboratory of Renewable Energy Sc ience and Engineering (LRESE) EPFL, Lausanne
8/09 Nano-Tera Meeting, Bern| 04 May, 2015
Gives as Great Opportunity to showcase and demonstrate our product as well as would be a brilliant chance to make new connections and attract tentative investors
9/09 Nano-Tera Meeting, Bern| 04 May, 2015
THANK YOU
Ø Wearable sensing devices will represent $47.4B market* in 2019
Ø Wearable electronics should be conformal, light weight and unno6ceable
Ø However current electronic solu@ons are rigid, planar and bulky.
* Source :Onworld Wearable Technologies Consumer Survey
Ø We are a wannabe EPFL Spin-‐off -‐ Prof. S. P. Lacour: Laboratory for soM bioelectronics interfaces
Ø Target Market: Electronic companies
Ø We provide B2B technological solu6ons to help industrial partners implement systems that can conform to the human body
Ø Robustness, Cost effec6veness Design flexibility
Ø Patent applica@on ongoing, backed by EPFL TTO
SolSticE
SolSticE SolSticE Solar Sticker for Energy
Highest Efficiency MaterialsFlexible
Adhesive
SolSticE SolSticE Applications
SolSticE SolSticE Benchmark
Flexibility
Com
fort
SolSticE SolSticE Planar VS Nanowire
p-doped
n-dopedintrinsic
10 µm
SolSticE SolSticE Achievements
Status
• First prototype on Si. • Peeling procedure
developed. • The Silicon wafer can be
reused. • The technique is scalable
independently on the wafer size.
SolSticE SolSticE Open Challenges
Status
• Realization of high conductivity and flexible contacts.
• Iterative optimization of the design.
• Scale up.
Princess Astronaut Wizard
SolSticE SolSticE The Team
Jelena Vukajlovic-Plestina
Dmitry Mikulik
Federico Matteini
CTO CEOCOO
November 2–4, 2015, MIT Media Lab, Cambridge, MA
SolSticE SolSticE