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  • Micro Total Analysis Systems 2005Volume 1

    Proceedings of uTAS 2005Ninth International Conference on Miniaturized

    Systems for Chemistry and Life Sciences

    Boston, Massachusetts, USAOctober 9-13, 2005

    edited by

    Klavs F. Jensen

    Massachusetts Institute of Technology, USA

    Jongyoon Han

    Massachusetts Institute ofTechnology, USA

    D. Jed Harrison

    University ofAlberta, CANADA

    Joel Voldman

    Massachusetts Institute ofTechnology, USA

    Sponsored by:Transducer Research Foundation

    TECHNISCHE

    INFORMATIQNSBJSUOTHOC

    UNIVERSITATSSIBLIOTHeKHANNOVER

    ISBN: 0-9743611-1-9

    TRF Catalog Number: 05TRF-0002

  • Day 1 - Monday, October 10,2005

    Plenary I

    MINIATURIZED SYSTEMS FOR DRUG DELIVERY AND TISSUE ENGINEERING

    R.S. LangerMassachusetts Institute ofTechnology, USA

    Concurrent Session 1A1 - Clinical System

    RAPID ALCOHOL TESTING IN WHOLE BLOOD BY DISK-BASED

    REAL-TIMEABSORPTION MEASUREMENT 1

    J. Steigcrt, L. Riegger, M. Grumann, T. Brenner, J. Ilarter, R. Zengerle,and J. Ducree

    IMTEK, University ofFreiburg, GERMANY

    ANALYSIS OF SALIVA SAMPLES FOR END-STAGE RENAL

    DISEASE DIAGNOSTICS USING AN IMAGING FIBER-OPTIC

    MULTIPLEXED MICROARRAY 4

    D.R. Walt, D. Rissin, C. DiCcsarc, T. Blicharz, and R. I layman

    Tufts University, USA

    DIFFERENTIAL EXTRACTION OF MALE AND FEMALE DNA IN AN

    AUTOMATED MICROFLUIDIC DEVICE 7

    A.J. Devitt, N. Aflatooni, M. Vinas, N. Loh, F. Pourahmacli, R. Yuan,and M.A. Northrup

    Microftuidic Systems, USA

    Concurrent Session 1BI - Flow Transport and Imaging

    CONVECTION-LIMITED SURFACE TRANSPORT IN

    NANOFLUIDIC CHANNELS 10

    T, Gervais, C. Tsau, J. El-Ali, S.R. Manalis, and K.F. JensenMassachusetts Institute of Technology, USA

    A DETECTION METHOD OF 3D PARTICLE-POSITIONS AND 3D

    MICROFLOW DIAGNOSTIC METHOD IN A MICROFLUIDICS 11

    S.Y. Yoon and K.C. Kim

    Pasan National University, KOREA

    x

  • 3D HIGH-SPEED TIME-RESOLVED FLUORESCENCE IMAGING OFSOLVENT INTERACTIONS IN MICROFLUIDIC DEVICES 16R.K.P Benninger, 0. Hofmann, J. McGinty, J. Requejo-Isidro, I. Munro,M.A.A. Neil, A.J. deMello, and P.M.W. FrenchImperial College London, UK

    Concurrent Session 1A2 - Immunoassay

    NONSPECIFIC BINDING REMOVALWITH ULTRASONICMICRODEVICES 19G.D. Meyer1, J.M. Moran-Mirabal1, D.W. Branch2, and H.G. Craighead.11 Cornell University, USA and 2Sandia National Laboratories, USA

    A POLYMER LAB-ON-A-CHIP FOR MAGNETIC IMMUNOASSAY

    WITH ON-CHIP SAMPLING AND DETECTION CAPABILITIES 22J. Do and CM. Aim

    University ofCincinnati, USA

    MICROFLUIDIC SANDWICH IMMUNOASSAYS FOR

    SUB-FEMTOMOLE DETECTION USING MAGNETIC

    FIELD-INDUCED NANOPARTICLES 25

    J.H. Kang, Y.K. Hahn, K.S. Kim, and J.K. ParkKorea Advanced Institute ofScience and Technology (KAIST), KOREA

    Concurrent Session 1B2 - Mixing/Pumping

    MICROFLUIDIC SERIAL TRANSFER CIRCUIT:

    AUTOMATED EVOLUTION OF RNA CATALYSTS 28

    B.M. Paegel and G.F. JoyceThe Scripps Research Institute, USA

    PERVAPORATION-DRIVEN MICROPUMPS:

    APPLICATION TO CRYSTALLINE GROWTH 31

    J. Leng1, B. Lonetti', P. Tabeling1, A. Ajdari1, and M. Joanicot2'ESPCJ, FRANCE and2Laboratory OfFuture (LOF), FRANCE

    INTEGRATED FLUID INJECTORS AND MIXERS FOR pH CONTROL

    IN MINIATURE BIOREACTOR ARRAYS 34

    H.L.T Lee and R.J. Ram

    Massachusetts Institute ofTechnology, USA

    Plenary II

    SUPRAMOLECULAR METALARRAYS AND METAL-MEDIATED

    MOLECULAR MOTIONS: ARTIFICIAL METALLO-DNA AND

    PEPTIDES, MOLECULAR BALL BEARINGS AND CONTAINERS 37

    M. ShionoyaUniversity ofTokyo, JAPAN

    XI

  • Poster Session Microfluidics - Fluid Manipulation

    A BIOMIMETIC ELASTOMERIC CHECK VALVE

    WITH DIODE BEHAVIOR 41

    P.J. Hung, P.J. Lee, J. Flu, J. Chen, V.M. Rao, and L.P. Lee

    University ofCalifornia at Berkeley, USA

    A FUNCTIONAL DISPOSABLE LAB-ON-A-CHIP WITH EMBEDDED

    MICRO PINCH VALVES FOR WHOLE BLOOD ANALYSIS 43

    J. Han'.C. Gao',J. Do'.S.H. Lee1, J. Kai',S. Lee1, L. Ramasamy1, J. Nevin1,G. Beaucage1, J.Y. Lee2, and C.H. Aim1'University of Cincinnati, USA and'Ohio State University, USA

    AC ELECTRIC FIELD DRIVEN MICROFLUIDIC CONTROL 46

    N.G. Green, S.J. Willmore, and II. Morgan

    University ofSouthampton, UK

    PATTERNING BIOLOGICAL SOLUTIONS USING ADDRESSABLE

    MICROFLUIDIC NETWORKS 49

    J.-Y. Shiu, C.-W. Kuo, and P. Chen

    Academia Sinica, TAIWAN

    CAPILLARY-ASSEMBLED MICROCHIP (CAs-CHIP):ON-CHIP INTEGRATION OF VALVING AND SENSING 52

    I-I. Hisamoto, S.-I. Funano, and S. Terabe

    University ofHyogo, JAPAN

    CHARACTERIZATION OF AN ELASTOMERIC MICROFLUIDIC

    ENERGY STORAGE DEVICE 55C. Easley, J. Karlinsey, and J. Landers

    University of Virginia, USA

    DESIGN AND VALIDATION OF A COMPLEX GENERIC FUIDIC

    MICROPROCESSOR BASED ON EWOD DROPLET FOR

    BIOLOGICAL APPLICATIONS 58Y. Fouillet, D. Jary, A.G. Brachet, C. Chabrol, J. Boulet, P. Clement/,D. Lauro, R. Charles, and C. PeponnetCommissariatea I'EnergieAtomique (CEA), FRANCE

    DEVELOPMENT OF A CHEMICAL-RESISTANT MICROVALVE

    ARRAY FOR RAPID PARALLEL BIOCHEMICAL SYNTHESIS AND

    ANALYSIS ON MICROCHIPS 61Z. Hua, Y. Xia, O. Srivannavil, and E. Gulari

    University ofMichigan, USA

    XII

  • ELECTROSTATIC ACTUATORS COMPOSED OF EXTENSIBLEGRAPHITE-PDMS COMPOSITE MEMBRANES 64R. Carlson and D. Meldrum

    University of Washington, USA

    FLOW PATTERNING BY PHASE-SHIFTED

    ELECTROOSMOTIC FLOWS 67F. Schonfeld1 and S Hardt1'2'Institut fiir Mikrotechnik Maim GmbH, GERMANYand2Darmstadt University of Technology, GERMANY

    GENERATION OF LOCAL IN-PLANE MICROVORTEXESACTUATED BY AC ELECTROOSMOSIS 70S.-H. Huang, S.-K. Wang, and F.-G. TsengNational Tsing Hua University, TAIWAN

    GENERATION OF STEADY FLOW IN SELF-CONTAINED

    MICROFLUIDIC SYSTEMS 73J. Atencia and D. Bcebe

    University of Wisconsin at Madison, USA

    MAGNETIC "QUASI-DIGITAL" FLOW REGULATORFOR DRUG INFUSOR 76

    M. Duch1, J. Esteve2, A. Salas1, R. PSrez-Castillejos1, M.C. Acero1, J.A. Plaza1,E. Vall6s2 and E. G6mez2;Centra Nacional Microelectronica, SPAIN and

    2Universitat de Barcelona, SPAIN

    MICROFLUIDIC MULTI-CHANNEL SYSTEM FOR POLYMERASE

    CHAIN REACTION WITH INTEGRATED LIQUID HANDLING 79O. Frey, A. Hicrlemann, and J, LichtenbergETII Zurich, SWITZERLAND

    MICROPARTICLE MIXING AND SEPARATION BYNONLINEAR

    ELECTROKINETIC EFFECTS IN MICROFLUIDIC CHANNELS 82

    C.K. Harnett1, A.J. Skulan1, T.F. Hill2, L.M. Barrett1, G.J. Fiechtner1,and E.B. Cummiiigs1'Sandia National Laboratories, USA and2Massachusetts Institute ofTechnology, USA

    ON-CHIP TUNABLE MICROFLUIDIC DYE LASER 85

    LC. Galas', J. Torres', and Y. Chen1'2'Laboratoire de Photonique et Nanostructures, FRANCE and2Ecole Normale Superieiire, FRANCE

    POLYMER ACTUATORS FOR LIQUID DISPLACEMENT

    INMICROCHANNELS 88

    M. Denoual and B. LepioufleSA TIE-Biomis, FRANCE

    xiii

  • POLYMER-BASED IN-CHANNEL ACTIVE MICROVALVE OPERATED

    BY PNEUMATIC/TFIERMOPNEUMATIC ACTUATION 91

    D.-K. Yoon, K.-S. Yun, and E. Yoon

    Korea Advanced Institute ofScience and Technology (KAIST), KOREA

    POWER-FREE SEQUENTIAL INJECTION FOR

    MICROCHIP IMMUNOASSAY 94

    K. Hosokawa, M. Omata, K. Sato, and M. Maeda

    RIKEN, JAPAN

    Poster Session Microfluidics - Fluid Mechanics and Modeling

    A SELF-PRIMING HIGH FLOW RATE ULTRASONIC

    VORTEX PUMP 97

    X. Chen and A. Lai

    Cornell University, USA

    DISPERSION IN MICROCHANNELS:

    THE IMPORTANCE OF THE WIDTH 100

    N. Bontoux1, A. Ajdari2, and H.A. Stone1'LPN, FRANCE, ''ESPCI, FRANCE, and 3Harvard University, USA

    EXPANSION CHANNEL FOR MICROCHIP FLOWCYTOMETER 103

    H. Bang\H. Yun', K.C. Clio2, C. Chung2, D.-C. Han1, and J.K. Chang''SeoulNational University, KOREA and'Digital Bio Technology, Inc., KOREA

    EXTENDING THE FUNCTIONALITIES OF SHEAR-DRIVEN

    CHROMATOGRAPHY NANO-CHANNELS USING

    HIGH ASPECT RATIO ETCHING 106

    W. De Malsche1'2, D. Clicq', H. Eghbali1, N. Vervoort1, II. Gardeniers\A. van den Berg2, and G. Desmet''Vrije Universiteit Brussel, BELGIUMand

    2

    University ofTwente, THE NETHERLANDS

    THREE-DIMENSIONAL MICROFLUIDIC FLOW FIELD

    CFIARACTERIZATION WITH PARTICAL IMAGE VELOCIMHTRY

    AND LASER SCANNING CONFOCAL MICROSCOPY 109

    S. Chao, M.R. Holl, L. Jang, and D.R. Mcldrum

    University of Washington, USA

    Poster Session Microfluidics - Multi Phase Fluidics

    A 0.25 PICOLITER ELECTROSTATIC MEMS S1DES1IOOTKR

    DROP DISPENSER 112

    P. Galambos, K. Pohl, D. Luck, and D. CzaplewskiSandia National Laboratories, USA

    XIV

  • CONTAMINATION-FREE DROPLET FUSION ANDCONTINUOUS-FLOW PCR

    115M. Chabert, K.D. Doriman, and J.-L. ViovyInstitut Curie, FRANCE

    DEPENDENCE OF THE NUMBER OF THEORETICAL PLATES OFMICRO COUNTER-CURRENT EXTRACTION ON FLOWRATES 118A. Aota, A. Hibara, and T. Kitamori

    University of Tokyo, JAPAN

    DETERMINATION OF MATRIX POLARITY OF TERNARYORGANIC SOLVENT MIXTURES USING A MICROSEGMENTED FLOW ASSEMBLY

    121P.M. GQnther', T. Sprogies1, Th. Frank2, J.M. Kohler1, and G.A. GroB1'Technical University afllmenau, GERMANY and

    2Little Things Factory, GERMANY

    EFFECTS OF FLUID ELASTICITY ON THE DYNAMICS OF DROPFORMATION IN MICROCHANNEL FLOWS 124J. Husny and J.J. Cooper-White

    University ofQueens/and, AUSTRALIA

    MICROFLUIDIC CHIPS SYSTEMS BASED ON STOPPED-FLOWLIQUID-LIQUID EXTRACTION 128Q. Fang, II. Chen, and Z.-L. FangZhejiang University, CHINA

    MICROTI IERMAL TECHNIQUES FOR MIXING, CONCENTRATION,AND HARVESTING OF DNA AND OTHER MICRODROPLET

    SUSPENSIONS 131A.S. Basu and Y.B. Gianchandani

    University ofMichigan, USA

    Poster Session Microfluidics - World-to-Chip Interfacing

    A MULTIFUNCTIONAL MACRO-TO-MICRO INTERFACE FOR

    HIGH THROUGHPUT MICROFLUIDIC SYSTEMS 135

    I. Meyvanlsson and D. Beebe

    University ofWisconsin at Madison, USA

    FORMATION OF PARALLEL MICROFLUIDIC CHANNELS WITH

    WEDGE COMPRESSION HIGH-DENSITY FLUIDIC INTERCONNECT

    TECHNIQUE AND MAGNETIC FORCE SEALING 138L.L. Clui' andF. Cerrina2'Genetic Assemblies, Inc., USA and2University ofWisconsin at Madison, USA

    xv

  • MICRO-WELL ARRAY INTERFACE FOR CAPILLARY ARRAY

    ELECTROPHORESIS 141

    C.R. Forest, B.L. Crane, and I.W. Hunter

    Massachusetts Institute ofTechnology, USA

    Poster Session Microfluidics - Others

    AN INTEGRATED AND REUSABLE ARRAY PCR GENETIC

    AMPLIFICATION AND CE DETECTION MICROFLUIDIC CHIP

    WITH INCORPORATED VALVES 145

    A.R. Prakash', L.M Pilarski2, C.J. Backhouse', and K.V.I.S. Kaler1

    'University ofCalgary, CANADA,2Cross Cancer Institute, CANADA, and

    JUniversity ofAlberta, CANADA

    DEVELOPMENT OF A STABLE CHEMICAL GRADIENT

    USING A CONVECTION-FREE PLATFORM 148

    V. Abhyankar and D. Beebe

    University of Wisconsin at Madison, USA

    IMAGING SURFACE PLASMON RESONANCE FOR MONITORING

    BIOMOLECULAR INTERACTIONS IN MICROFLUIDIC DEVICES 151

    R.B.M Schasfoort1, B. Beusink1, S. Schlautmann', A.J. Tiidos', and G.1I.M. Engbers'11

    University ofTwente, THE NETHERLANDS and

    2IBIS Technologies B. V., THE NETHERLANDS

    Poster Session Microfabrication - MEMS

    A CHRONIC DRUG-DELIVERY PROBE WITH ON-CHIP

    CORRUGATED MICROVALVES 154

    K. Baek, Y. Li, M. Gulari, and K.D. Wise

    University ofMichigan, USA

    A DEVICE INTEGRATING PARAFFIN MICROACTUATOR,

    FLUIDIC COMPARTMENT AND MICRONEEDLE: ARRAY FOR

    FLUID INJECTION OR SAMPLING 157

    I-I. Yousef1, M. Lehto', T. Jttdcrblom1,1. Enculescu1'2, and K. Iljori';Uppsala University, SWEDEN and2National Institute ofMaterial Phvsics, ROMANIA

    A NOVEL HIGH ENERGY DENSITY DIELECTRIC ELASTOMER

    ACTUATOR FOR MICRO ANAYS1S SYSTEMS 160

    J.J. Loverich, I. Kanno, and II. Kolera

    Kyoto University, JAPAN

    A SIMPLE TWO TERMINAL LONGITUDINAL HOTWIRE SENSOR

    FOR MONITORING THE POSITION AND SPEED OF ADVANCING

    LIQUID FRONTS IN MICRO CHANNELS 163

    K. Ryu, K. Shaikh, E, Goluch, P. Mathias, and C. Liu

    University ofIllinois at Urbanu-Champaign, USA

    XVI

  • A THREE-DIMENSIONAL SUBSTRATE FOR CARDIAC MYOCYTEORIENTATION AND CONTRACTION FORCE MEASUREMENTS 166Y. Zhao and X. ZhangBoston University, USA

    CONTACTLESS ELECTROCHEMICAL ACTUATOR FOR PRECISESAMPLING ON MICROCHIP

    169L. Metref, F. Herrera, D. Berdat, and M. GijsEcole Polytechnique Federate de Lausanne, SWITZERLAND

    SWITCHABLE STIFFNESS NANOSCANNING PROBE FOR

    BIOLOGICAL APPLICATIONS 172C. Mucller-Falcke, S. Gouda, S. Kim, and S.-G. KimMassachusetts Institute of Technology, USA

    Poster Session Microfabrication - Micromachining

    A SHADOW-MASK TO MAKE HALF MILLION SUBMICRON

    SQUARE PATTERNS AT ONCE 175M.C. Tarhan, A. Tixier-Mita, and H. FujitaUniversity of Tokyo, JAPAN

    CONTROLLED OUT-OF-PLANE POSITIONING OF MICROFLUIDIC

    COMPONENTS IN SU-8 DRIVEN BY PLASTIC STRAIN 178

    D. Haelligcr and A. BoisenTechnical University ofDenmark, DENMARK

    FULLY-DRY FABRICATION OF MONOLITHIC HIGH-ASPECT-RATIO

    EMBEDDED FARYLENE M1CROCFIANNELS 181

    P.-J. Chen, D. Rodger, and Y.-C. Tai

    California Institute ofTechnology, USA

    Poster Session Microfabrication - Polymer Technology

    MICROFLUIDIC POLYETHER ETHER KETON (PEEK) CHIPSCOMBINED WITH CONTACTLESS CONDUCTIVITY

    DETECTION FOR uTAS 184

    II. Muhlberger, A.E. Guber, and W. Hoffmann

    Forscluingszcnlnim Karlsruhe, GERMANY

    FABRICATION OF A HOLLOW METALLIC MICRONEEDLE

    ARRAY USING SCANNING LASER DIRECT WRITING 187

    II. Yu\ K. Shiba1, B. Li2, and X. Zhang''Boston University, USA and-

    Fraunhofer USA Centerfor Manufacturing Innovation, USA

    XVII

  • FABRICATION OF ADDRESSABLE MICROSTRIP AS COMPONENTS

    FOR THE BIOANALYSIS OR M1CROACTUATION 190

    S.R. Kim, J.Y. Baek, D.J. Kim, G.H. Kwon, and S.H. Lee

    Dankook University, KOREA

    INJECTION MOLDING OF MICROFLUIDIC CHIPS BY

    EPOXY-BASED MASTER TOOLS 193

    T. Brenner', N. Gottschlich2, G. Knebel2, C. Mueller1, II. Reineeke1,R. Zengerle', and J. Ducree''IMTEK, University ofFreiburg, GERMANYand2 Greiner-Bio One GmbH. GERMANY

    PHASE-CHANGING SACRIFICIAL MATERIALS FOR Till' FABRICATION

    OF MICROFLUIDIC ANALYSIS SYSTEMS IN POLYMERS 196

    R.T. Kelly, P.H. Humble, M.L. Lee, and A.T. WoolleyBrigham Young University, USA

    SCANNING LASERPRODUCES FUNCTIONAL MICROFLUIDIC

    STRUCTURES AT A SINGLE SU-8 LAYER 199

    A. Gueit, A. Sharon, and B. Li

    Fraunhofer USA Centerfor Manufacturing Innovation, USA

    SURFACE MODIFICATION, MECHANICAL PROPERTY, AND

    MULTI-LAYER BONDING OF PDMS AND ITS APPLICATION 202

    O.C. Jeong', T. Yamamolo2, S.W. Lee2, T. Fujii2, and S. Konishi'1Ritsumeikan University, JAPAN and2 University of Tokyo, JAPAN

    WAFER-SCALE M1CROMOLD1NG OF UNITARY POLYMERIC

    MICROSTRUCTURES WITH SIMULTANEOUSLY FORMED

    FUNCTIONAL METAL SURFACE 205X. Wu, Y. Zhao, Y.-K. Yoon, S.-O. Choi, J.-II. Park, and M.Ci. Allen

    Georgia Institute of Technology, USA

    Poster Session Microfabrication - Others

    A SIMPLE TECFIN1QUE FOR INCORPORATING HETEROGENEOUSCATALYSTS INTO MICROREACTORS 208A. lies', R. Woolton2, M. llabgood2, R. Fortt2, and A.J. deMello''National Institutefor Materials Science, JAPAN and2Imperial College London, UK

    LTCC TECHNOLOGY FOR VARIOUS MICROSYSTEM APPLICATIONS 211L. Golonka', K. Malecha', I-I. Roguszezak', D. Stadnik2,1. Orabowska",M. Chudy2, A. Dybko2, and Z. Brzozka2'^Wroclaw University of Technology, POLAND and2Warsaw University ofTechnology, POLAND

    XVIII

  • Poster Session Nanotechnology - Nanobiotechnology

    AN INTEGRATED MICROFLUIDIC PROCESSOR FOR SINGLENUCLEOTIDE POLYMORPHISM-BASED DNA COMPUTING 214W.H. Grover and R.A. Mathics

    University ofCalifornia at Berkeley, USA

    FABRICATION OF MICROCANTILEVER WITH

    NANO-INTERD1GITATED ELECTRODES (IDES) FORDNA BINDING PROTEIN DETECTION 217J.A. Lee1, J.Y. Yun', K.-C. Lee2, S.I. Park2, and S.S. Lee1'Korea Advanced Institute ofScience and Technology (KAIST), KOREA and2Korea Research Institute ofStandards and Science (KR1SS), KOREA

    FABRICATION OF MONODISPERSE, SHAPE-SPECIFICNANOPART1CLES FOR USE AS DELIVERY VECTORS 220G. Denison1, J. Rolland1, B. Maynor2, L. Euliss2, and J.M. DeSimone2'Liquidia Technologies, USA and2University ofNorth Carolina, USA

    FORMATION AND STABILITY OF A SUSPENDED LIPID

    BILAYER ON SILICON SUBMICRON SIZE PORES 223A. Simon, F. Sauler, C. Pudda, L. Ghenim, N. Picollet D'hahan, F. Chatelain,and A. Fuchs

    Coinmissariale a I'EnergieAtomique (CEA), FRANCE

    SELECTIVE FUNCTIONALIZATION OF CANTILEVER,BIOSENSORS USING A MICROARRAY SPOTTER 226

    K.L. Aubin, S.M. Park, J.M. Moran-Mirabal, B.R, Hie, M. Kondratovich,D.M. Lin, and II.G. CraigheadCornell University, USA

    TEMPERATURE DEPENDENT ANGULAR VELOCITY

    MEASUREMENT OF Fl-ATPASE BIOMOLECULAR MOTOR

    BY MICRO FABRICATED LOCAL HEATING DEVICE 229

    II. Arata, H. Noji, and 11. FujitaUniversity of Tokyo, JAPAN

    Poster Session Nanotechnology - Nanofluidics

    CHEMICAL REACTION BY MIXING IN NANOCHANNEL

    UTILIZING PRESSURE-DRIVEN FLOW CONTROL SYSTEM 232

    E. Tamaki1, A. Hibara2, T. Tsukahara2, H.B. Kim2, and T. Kitamon1'2'3'Japan Science and Technology Agency, JAPAN,2

    University ofTokyo, JAPAN, and

    JKanagawa Academy ofScience and Technology (KAST), JAPAN

    XIX

  • HYBRID ATOMISTIC/CONTINUUM MODELING OF

    ELECTROOSMOTIC FLOW IN NANOSCALE CHANNELS 235

    R. Nilson and S. Griffiths

    Sandia National Laboratories, USA

    EFFICIENT BIOMOLECULE PRE-CONCENTRATION BY

    NANOFILTER TRIGGERED ELECTROKINETIC TRAPPING 238

    Y.-C. Wang, C. Tsau, T. Burg, S. Manalis, and J. Han

    Massachusetts Institute of Technology, USA

    Poster Session Nanotechnology - Nanoengineering

    ANANOFLU1DIC ELECTROSPRAY SOURCE; FABRICATED

    USING FOCUSED ION BEAM ETCHING .. 241

    C. Descatoire1, D. Troadcc1, L. Buehaillot1, A. Ashcrofr, and S. Arscott1

    'lnstitut d'Eleclronique, de Mieroelectronique et de Nunotcchnologie, FRANC 'E and

    2Astbury Centrefor Structural Molecular Biology, UK

    FABRICATION OF SILICA NANOCHANNHLS VIA SCANNED

    COAXIAL ELECTROSPINNING 244

    M. Wang1, N. Jing1, C.-K. Choir, M.-C. Hung2, and J. Kameoka''Texas A&M University, USA and2 University of Texas, USA

    Poster Session Materials & Surface - Surface Modification

    ADHESION MECHANISMS FOR PHASE SEPARATED POLYMER

    FILMS USING INTERLOCKING MICROSTRUCTURES AND

    SURFACE CHEMICAL TREATMENT 247

    G. Subrebost and G.K. Fcdder

    Carnegie Mellon University, USA

    ENGINEERING MICROFLUIDIC CHIPS WITH INTEGRATED

    BINDING SITES FOR ULTRAMINIATURIZED IMMUNOASSAYS 250

    J.O. Foley, H. Schmid, R. Stutz, and E. Delamarche

    IBM Research GmbH, SWITZERLAND

    PROTEIN ADSORPTION RESISTANCE BY BIOCOMPATIBLE

    PHOSPOLIPID POLYMERS AS A SURFACE: MODIFICATION

    ONPDMS 253

    K. Ishihara, J. Sibarani, and M. Takai

    University ofTokyo, JAPAN

    SUPERHYDROPHOB1C AND HYDROPH1L1C STATES ON

    POROUS SILICON FOR BIOAPPLICATIONS 256

    A. Ressine, D. Finnskog, G. Marko-Varga, and T. l.aurellLund University, SWEDEN

  • SURFACE MODIFICATION OF PDMS MICROFLUIDIC DEVICESUSING TRANSITION METAL SOL-GEL CHEMISTRY 259C.T.Culberlson and G.T.RomanKansas State University, USA

    Poster Session Materials & Surface - Nanostructured Materials

    A METAL-ORGANIC FRAMEWORK BASED PRECONCENTRATORFOR GAS SAMPLING IN A MICRO-GAS CHROMATOGRAPH 262Z. Ni, M. Shannon, K. Cadwallader, J. Jerrell, and R. MaselUniversity ofIllinois at Urhana-Champaign, USA

    MICROFLUIDIC SURFACE-ENGINEERING OFCOLLOIDAL NANOPARTICLES

    265S. Khan and K. Jensen

    Massachusetts Institute of Technology, USA

    Poster Session Materials & Surface - Interface Characterization

    A MULTI-TECHNIQUES APPROACHTO THE CHARACTERIZATIONOF MICROCHIP SURFACE STATE AND TREATMENTS 268R. Attia, A. Pallandre, B. de Lambert, E. Psichari, and J.-L. ViovyInstitut Curie, FRANCE

    Poster Session Applications - Genomics and Protcomics

    A PLUG-AND-PLAY SINGLE-STEP CAPILLARY

    ELECTROPHORESIS SYSTEM 271K. Ono' anclT. Fujii21Enplas Laboratories, Inc., JAPAN and

    2University ofTokyo, JAPAN

    HIGH PRECISION PROFILING OF GLYCOPEPTIDES

    USING I1PLC-CHIP/MSTOF 274

    K. Killeen1,11. Yin', R. Brennen1, K. Seaward1, R. Grimm2, X. Li3, H. Zhang3,and R. Aebersold3

    'Agilent Technologies, USA, 'Agilent Technologies, GERMANY, and'institutefor Systems Biology, USA

    HIGH THROUGHPUT COMPACT PROTEIN

    CRYSTALLIZATION DEVICE 277

    M.l. Al-Maq1;2, H. Lebrasscur1, W.-K. Choi1-2, T. Torii1, H. Yamazaki2,E. Shinohora", and T, Higuehi1'University ofTokyo, JAPAN and2 TechnoMedica Co., Ltd., JAPAN

    INCREASED PROTEIN DIGESTION RATE IN POROUS SILICON

    NANOVIALS ARRAYS 280

    D. Finnskog, A. Ressine, G. Marko-Varga, and T. LaureflLund University, SWEDEN

    xxi

  • QUANTITATIVE STUDY OF THE ADSORPTION OF PCR REAGENTS

    DURING ON-CHIP BI-DIRECTIONAL SHUNTING PCR 283

    P.-A. Auroux.1, P.J.R. Day2, and A. Manz3

    'Imperial College London, UK,2University ofManchester. UK, and

    3Institutefor Analytical Sciences (ISAS), GERMANY

    RADICALACTIVATED CLEAVAGE OF PEPTIDES AND PROTEINS:

    AN ALTERNATIVE TO PROTEOLYTIC DIGESTION 286

    B. Jones', L. Locascio2, and M. Hayes''Arizona State University, USA and2National Institute ofStandards and Technology, USA

    Poster Session Applications - Clinical Diagnostics

    A DISPOSABLE MICROFLUIDIC DEVICE FOR CELL LYSIS

    AND DNA ISOLATION 289

    J. Wang, M. Mauk, Z. Chen, and 1I.H. Bau

    University ofPennsylvania, USA

    A LAB-ON-CHIP FOR RAPID DNA-BASED IDENTIFICATION

    OF STREPTOCOCCUS PNEUMONIAE 292

    B. Fouque', A.-G. Brachct', F. Marcel', R. Dupont1, G. Delapierre',A. Fischetti2, J. Jalava3, and F. Chatelain1

    'CEA, FRANCE, 2ST Microelectronics, ITALY, and'

    Mohidiag, FINLAND

    BONT RESPONSIVE HYDROGELS AS SENSORS

    IN MICROCHANNELS 295

    K. Plunkett1, J. Moorthy2, W. Tepp\ K. Berkowski', I-;. Johnson-, J. Moore',and D. Beebe2

    'University ofIllinois at Urbana-Champaign, USA and2

    University of Wisconsin at Madison, USA

    DETECTION OF MUTANT ALLELES IN WILD-TYPE BACKGROUND

    TOWARDS AN EARLY PANCREATIC CANCER DETECTION 298

    S. Ananthnarayan', F. McCormiek', 0. Ileid2, M. linger2, G. Facer.E. Quan2, and A. Daridon2'University ofCalifornia at San Francisco, USA and "Fluidigm Corporation, USA

    FOIL-BASED BIOMEMS FOR ELECTROCHEMICAL

    CAPILLARY IMMUNOASSAYS 301

    I. Moser', B. Enderle1, G. Jobst2, and G. Urban1'IMTEK, University ofFreiburg, GERMANY and '\lohst Technologies. GERMANY

    HIGH SPEED, MULTI-CHANNEL MICROFLUIDIC SYSTEMFOR MULTI-PATHOGENS SEROLOGY MONITORING 304

    H. Aoki, Y. Nakamura, M. Tojo, T. Hara, Y. Yamagata, T. Nagamune, and H. Kase

    'Fuence Company, Ltd., JAPAN, 2RIKEN, JAPAN, and 'University of Tokyo, JAPAN

    XXII

  • AN INTEGRATED MICRO CELL COUNTING ANDCONCENTRATION SENSING CHIP

    307D.W. Lee, S. Yi, and Y.-H. ChoKorea Advanced Institute ofScience and Technology (KAIST), KOREA

    ON-CHIP PPT LEVEL ENZYME IMMUNOASSAY OF B-TYPENATRIURETIC PEPTIDE USING A PDMS BASED MICROFLUIDICDEVICE COMBINED WITH A PORTABLE SURFACE PLASMONRESONANCE SYSTEM

    3]0R. Kurita, Y. Sato, F. Mizulani, and 0. NiwaNational Institute for Advanced Industrial Science and Technology (AIST), JAPAN

    RAPID BACTERIA COUNTING BY MULTI-STEP BIOCHEMICALREACTION IN A MICROFLUIDIC DEVICE 313T. Kogure, T. Matsuno, E. Kawata, K. Noda, M. Sakata, and A. TokidaBussan Nanotech Research Institute Inc., JAPAN

    Poster Session Applications - Microarrays

    CELL ARRAYS ON CHIP 316M. Zhong, N. Yang, Y.-H. Choi, and D.J. Harrison

    University ofAlberta, CANADA

    HIGH-THROUGHPUT REAL TIME MEASUREMENTS OFDNA HYBRIDIZATION IN A DOUBLE LAYER

    POLYDIMETIIYLSILOXANE MICROSYSTEM 319J. Goulpeau1'2, D. Le Clerre3, F. Richard3, L. Talini3, D. Trouchet2, and P. Tabeling1'ESPCI, FRANCE, 2Berlin Technologies, FRANCE, and3 Genescore, FRANCE

    HIGH-THROUGHPUT SCREENING OF MUTANT

    AKR ENZYMES USING MRNA DISPLAY AND NOVEL

    MICROREACTOR ARRAY CHIPS 322

    Y. Ilosoi'.K. Takahashi', M. Biyani2,N. Nemoto3, T. Akagi3, and T. Ichiki1'4'University ofTokyo, JAPAN, 2Saitama Small Enterprise Promotion Corporation,

    JAPAN, National Institute for AdvancedIndustrial Science and Technology (AIST),JAPAN, and

    A

    Japan Science and Technology Agency (JST), JAPAN

    INTEGRATED MICROFLUIDIC DEVICE FOR GENE

    EXPRESSION M1CR0ARRAY 325

    R. Liu, T. Nguyen, K. Schwarzkopf, K. Peyvan, and S. FujiComhiMutrix Corp., USA

    RAPID CENTRIFUGAL PROCESSING OF

    MICROARRAY EXPERIMENTS 328

    M. Grumann1, M. Dube2,0. Gutmann1, S. Lute1, J. Steigert1, L. Riegger1,K. Mittmann2, M. Daub', R. Zengerle', and J. Ducre'e1'IMTEK, University ofFreiburg, GERMANY and2University ofApplied Sciences Minister, GERMANY

    xxiii

  • Poster Session Applications - Separation Science

    APPLICATION OF THERMAL LENS MICROSCOPY AND SWEEPING

    FOR HIGHLY SENSITIVE DETECTION IN ELECTROPHORETIC

    ANALYSYS ON CYCLOOLEFIN POLYMER MICROCHIPS 331

    F. Kitagawa1, T. Tsuneka1, Y. Akimoto1, J. Mizuno2, S. Shoji2, and K. Otsuka1'Kyoto University, JAPAN and2 Waseda University, JAPAN

    DYNAMIC COATING ON PMMA CE MICROCHIP FOR

    SIZE-BASED PROTEINS SEPARATION 334II.Okada'andY. Baba21Nagoya University, JAPAN and

    2National Institute ofAdvanced Industrial Science and Technology (AIST). JAPAN

    EFFECT OF SUB-MICRON PILLAR ARRAY ON DNA

    KINETICS IN A FREE-SOLUTION CAPILLARY

    ELECTROPHORESIS MICROSYSTEM 337Y.C. Chan1, Y.-K. Lee1, M. Wong1, and Y. Zohar'Hong Kong University ofScience and Technology. CHINA ami2University ofArizona, USA

    NOVEL MIGRATION PHENOMENA IN STRUCTURED

    MICROFLUIDIC DEVICES 340

    J. Regtmeier, T.T. Duong, R. Eichhorn, D. Anselmelti, P. Reimann, and A. RosBielefeld University, GERMANY

    SINGLE-MASK TECHNOLOGY FOR ON-CHIP

    HIGH-PRESSURE 1IPLC SYSTEM 343C.-Y.ShihandY.C. Tai

    California Institute of Technology, USA

    TUNABLE PINCHED FLOW FRACTIONATION FOR EFFECTIVE

    PARTICLE SEPARATION IN MICROFLUIDIC DEVICES 346Y. Sai', M. Yamada2, M. Yasuda', and M. Seki1'Osaka Prefecture University, JAPAN and2University ofTokyo, JAPAN

    ULTRASONIC CHROMATOGRAPHY IN SILICON-BASED

    MICROFLUIDIC SYSTEM 349M.K. Araz and A. Lai

    Cornell University, USA

    Poster Session Applications - Cell Handling and Analysis

    A CELL MICRODISPENSER FOR ACCURATI-POSITIONING OF SINGLE CELL 352V. Haguet1, F. Rivera2, U. Seger2, N. Picollet-D'haluiii', P. Rcnaud',and F. Chatelain'

    'CEA Grenoble, FRANCE and:EPFL, SWITZERLAND

    XXIV

  • CELL SORTING IN A MICRO-FLUIDIC SYSTEM WITHMAGNETIC NANOPARTICLES

    355E. Psychari, A.-E. Saliba, C. Fultcrer, M. Slovakova, C. Goubault, aiidJ.-L. viovyCurie Institute, FRANCE

    CONTINUOUS FLOW DIFFUSIVE FILTER FOR

    APHERESIS OF WHOLE BLOOD358

    P. Sethu and M. Toner

    Massachusetts General Hospital, Harvard Medical School, andShriners Burns Hospital. USA

    CULTURING EMBRYOS ON ENDOMETRIUM TISSUE PREFORMEDIN A MICROFLUIDIC DEVICE: ANEW TOOL FOR ART

    (ASSISTED REPRODUCTIVE TECHNOLOGY) 361S. Ostrovidov1'2, J. Mizuno\ II. Nakamura3, H. Inui3, Y. Sakai1, and T. Fujii1'University of Tokyo, JAPAN,

    2PENTAX Corporation, JAPAN, and

    3Inui Institute for Frontier Reproductive Medicine and Infertility, JAPAN

    STUDY OF BREAST CANCER USING WHOLE CELL

    IMPEDANCE: SPECTROSCOPY 364A. Han1, L.J. Cruz-Rivera1, L. Yang2, and A.B. Frazier''Georgia Institute ofTechnology, USA and2Emoiy University, USA

    ELECTRICAL ASSISTED PATTERNING OF CARDIAC MYOCYTES

    USING MICROFLUIDIC DEVICEAS A PLATFORMFOR

    CARDIOVASCULAR ELECTRICAL STIMULATION STUDY 367

    M. Yang and X. ZhangBoston University, USA

    ELECTRONIC SORTING AND RECOVERY OF SINGLE LIVE

    CELLS FROM MICROLITER SIZED SAMPLES 370

    A. Fuehs', D. Freida', M. Abonnene2, G. Medoro2, L. Altomare3, A. Romani3,I. van Uitert'1, M, Tartagni', R. Guerrieri3, F. Chatelain', and N. Manaresi2'CEA, FRANCE. :Silicon Biosystems, ITALY, "University ofBologna, ITALY, and''University ofTwettte, THE NETHERLANDS

    EVALUATION OF CELL CYCLE STAGE BY ELECTROPHORETIC

    MOBILITY USING A MICRO CAPILLARY ELECTROPFIORESIS CHIP 373

    T. Akagi', K. Takahashi1, and T. Ichiki1'2'University ofTokyo, JAPAN and:Japan Science and Technology Agency (JST), JAPAN

    HIGHLY ADAPTABLE: M1CROSTRUCTURED 3D CELL CULTURE

    PLATFORM IN THE % WELL FORMAT FOR STEM CELL

    DIFFERENTIATION AND CHARACTERIZATION 376

    S. Gisclbrechi1, R. TruckcnmQlIcr1, A. Welle', K.-F. Weibezahn1, A. Schober2,G. SchlinglolT2, and E. Goltwald''

    Forschungszcntrwn Karlsruhe. GERMANY and

    2Technische Univcrsitut Iliiicnatt, GERMANY

    XXV

  • LARGE SCALE SINGLE CELL ANALYSIS USING HIGH DENSITY

    HYDRODYNAMIC TRAPPING ARRAYS 379

    D. Di Carlo, N. Aghdam, P.J. Flung, and L.P. Lee

    University ofCalifornia at Berkeley, USA

    LARGE-SCALE PARAMETRIC STUDY OF ELECTROPORATION

    IN CANCERCELLS TO CONSTRUCT PHASE. DIAGRAMS USING

    MICRO CELL-ARRAY CHIPS 382

    H. He, D.C. Chang, and Y.-K. Lee

    Hong Kong University ofScience and Technology, C1I1NA

    MEMS DEVICE FOR CONTINUOUS BLOOD CELL SEPARATION 385

    S. Zheng1, Y.-C. Tai1, and H.L. Kasdan2'California Institute ofTechnology, USA and

    2IRIS International. Inc.. USA

    MICROFLUIDIC DEVICE WITH INTEGRATED ANTIBODY

    ARRAYS FOR CELL SIGNALING ANALYSIS 388

    J. El-Ali1, S. Gaudet1, K.P. Murphy, Jr.2, U.B. Nielsen2, and K.F. Jensen''Massachusetts Institute of Technology, USA and

    2Merrimack Pharmaceuticals Inc., USA

    MICROFLUIDIC DEVICE FOR ELECTRIC-FIELD DRIVEN

    SINGLE-CELL CAPTURE AND ACTIVATION 391

    E.S. Douglas, N.M. Toricllo, and R.A. Mathies

    University ofCalifornia at Berkeley, USA

    MICROFUNNELS FOR CHIP-BASED PATCH-CLAMP EXPERIMENTS 394

    T. Lehnert, D.M.T. Nguyen, L. Baldi, and M.A.M. CiijsEcole Polytechnique Federale de Lausanne, SWITZERLAND

    MICROFLUIDIC DEVICE FOR THE STUDY OF NEUTROPHIL

    RESPONSE TO RAPIDLY CHANGING GRADIENTS 397

    D. Irimia', S.-Y. Liu2, W. Tharp2, A. Samadani1, M. Toner', and M. Po/nnnsky''Harvard University, USA, 2Massachusetts General Hospital, USA, and3Massachusetts Institute ofTechnology, USA

    PLANARNANONEEDLES ON-CHIP FOR

    INTRACELLULAR MEASUREMENTS 400

    J. Emmelkamp, J.G.E. Gardeniers, II. Andersson, and A. van den Berg

    University ofTwenle, THE NETHERLANDS

    SINGLE CELL POSITIONING, ENTRAPMENT AND

    ELECTRICAL CHARACTERISATION 403

    T. Brasehler, R. Johann, U. Seger, P. Linderholm, N. Demierre, and P. RenaudSwiss Federal Institute ofTechnology ofLausanne, SWITZERLAND

    XXVI

  • .406

    TOWARDS SINGLE CELL FINGERPRINTING IN MICROFLUIDICDEVICE FORMAT: SINGLE CELL MANIPULATION, PROTEINSEPARATION AND DETECTION

    W. Hellmich, K. Leflhalm, A. Sischka, T. Duong, N. Jensen, K. Nieii'aus,K. Tfinsing, A. Ros, and D. Anselmelti

    Bielefeld University, GERMANY

    TRANSISTOR-LESS, MASSIVELY-PARALLEL MANIPULATION OFINDIVIDUAL CELLS BY ^ELECTROPHORESIS 409G. Mecloro1'2, N. Manaresi1, M. Tartagni2, and R. Guerrieri2'Silicon Biosyslems S.r.l., ITALYand ' University ofBologna, ITALY

    Poster Session Applications - Chemical Synthesis

    IONIC LIQUID DROPLET AS MICROREACTORDISPLACED BYELECTROWETT1NG ON DIELECTRIC 412Ph. Dubois1'2, G. Marchand', Y. Fouillet', C. Peponnet1, C. Chabrol1,J. Bcrthier1, and M. Vaullier1Commissariate a I'Energie Atomique (CEA), FRANCE and2University ofRennes, FRANCE

    MASSIVELY PARALLEL OLIGONUCLEOTIDE SYNTHESIS USING

    MICROMAC1IINED BEAD-ARRAY M1CROWELL PLATE AND

    LIGHT-DIRECTED CHEMISTRY 415

    L.L. Chu', M.-1I. Li2, and F. Cerrina3'Genetic Assemblies, Inc., USA,2National University ofSingapore, SINGAPORE, and3University of Wisconsin, USA

    ONLINE MONITORING iW REACTION INTERMEDIATES IN

    CONTINUOUS FLOW MICROFLUIDIC SYSTEMS 418

    R. Winkle', R. Wootton', G. Walter2, and A. deMello1

    'imperial College London, UK and "Syngenta, UK

    Poster Session Applications - Drug Discovery

    A MICROFLUIDIC ARRAY OF PRIMARY MAMMALIAN HEPATOCYTES

    FOR USE IN HIGH-THROUGHPUT DRUG SCREENING 421

    B.J. Kane1, M.J. /inner1, M.L. Yarmush2'3,4, and M. Toner2'3'41Brigham and Women's Hospital, USA, 'Massachusetts General Hospital, USA,

    3Harvard Medical School, USA, and "Shriners Hospitalfor Children, USA

    MICROFLUIDIC CELL MIGRATION DEVICE FOR ACCELERATING

    DRUG DEVELOPMENT IN CANCER METASTASIS 424K.C. Chaw1,2. M. Manimaran1, and E.1I. Tay1,2'Institute ofBioengmeering and Nunotechology, SINGAPORE and

    2NUS, SINGAPORE

    XXVII

  • Poster Session Applications - Environmental

    HEAVY METAL MEASUREMENT IN MICROFLUIDIC

    CHANNEL BY CONFINED LIQUID ELECTRODE PLASMA

    OPTICAL EMISSION SPECTROMETRY 427

    H. Matsumoto', A. Iiduka1, T. Yamamoto2, E. Tamiya1, and Y. Takamura1,3

    'Japan Advanced Institute ofScience and Technology (JAIST), JAPAN,2TenorInc, JAPAN, and3Japan Science and Technology Agency (JST), JAPAN

    Poster Session Applications - Others

    A MULTICIIIP-ARCHITECTURE-BASED FLEXIBLE AND EXTENDIBLE

    NEURAL STIMULATION DEVICE FOR RETINAL PROSTHESIS 430

    T. Tokuda1, A. Uehara1'2, J. Ohta1, Y. Terasawa2, M. O/awa", T. Fujikado',and Y. Tano3'Nara Institute ofScience and Technology, JAPAN, 2Nidek Co.. Ltd.. JAPAN, and

    3Osaka University Medical School, JAPAN

    ANEW AUTONOMOUS IMPLANTABLE MICRO POWER SUPPLY USING

    BONE STRAIN-BASED PIEZOELECTRIC ENERGY HARVESTING 433

    J.J, Loverich, I. Kanno, and II. Kotera

    Kyoto University, JAPAN

    APPLICATION OF MAGNETIC MICROMACTIINE FOR M1CROPUMP 436

    S.I. Hisatomi1, A. Yamazaki1, K. Ishiyama1, S. Agatsuma1, M. Sendolr,and K.I. Arai1

    'Tohoku University, JAPAN and

    2Miyagi Organization for Industry Promotion, JAPAN

    IIYDRODYNAMICALLY CONTROLLED DROPLET BREAKUP

    IN MICROFLUIDIC DEVICES 439

    S. Doi1, M. Yamada2, M. Yasuda1, and M. Seki''Osaka Prefecture University. JAPAN and2University of Tokyo, JAPAN

    RAISED LATERAL PATCH CLAMP ARRAY IN

    OPEN-ACCESS FLUIDIC SYSTEM 442

    A, Lau, P. Hung, and L,P. Lee

    University ofCalifornia at Berkeley, USA

    PREPARATION AND ELECTRICALLY MONITORED

    MANIPULATION OF GIANT LIPID VESICLES FOR

    IMPROVED MASS TRANSPORT ON-CHIP 445

    E.S. Lee, D. Robinson, J.L. Rognlien, C.K. Harnett, B.A. Simmons,C.R. Bowe Ellis, P.M. Dentinger, CM. Munoz, and R.V. DavalosSanc/ia National Laboratories, USA

    xxviii

  • Poster Session Detection Technologies - Optical

    3D INTEGRATION OF MICROLENSES TO REALIZE ALOW-POWER AND HIGH-SENSITIVITY OPTICAL DETECTIONSYSTEM FOR A DISPOSABLE LAB-ON-A-CHIP 449S.-I. Chang and J.-B. Yoon

    Korea Advanced Institute ofScience and Technology (KAIST), KOREA

    DEVELOPMENT OF UV THERMAL LENS MICROSCOPE (UV-TLM) FORULTRASENSITIVE AND DIRECT DETECTION OF NON-LABELEDBIOMOLECTJLES ON A MICROCHIP 452M. Tokeshi1, S. lliki2, K. Mawatari1, A. Hibara3, and T. Kitamori3'Kanagawa Academy of Science and Technology (KAST), JAPAN,

    2Institute ofMicrochemieal Technology, JAPAN, and 3University ofTokyo, JAPAN

    MICROALBUMINURIA DETERMINATION ON A MICROCHIP

    WITH FLUORESCENCE DETECTION BASED ON THIN-FILM

    ORGANIC LIGHT EMITTING DIODES 455

    0. Uol'mann', X. Wang2, J.C. deMello2, D.D.C. Bradley2, and A.J. deMello2'Molecular Vision Ltd., UK and 2Imperial College London, UK

    MICR0MACHINEDA-S1:I1 FLUORESCENCE DETECTOR 458

    T. Kamei1, M. Nagao1, and T. Wada2'National Institute ofAdvanced Industrial Science and Technology (AIST), JAPAN and2Fuji Electric Device Teclmologv Co. Ltd., JAPAN

    PROTEIN BINDING DETECTION IN COMPACT PHOTONIC

    CRYSTAL M1CR0CAV1TIES 461

    L. Mirkarimi, E. Chow, D.I1. Yang, M.A, Bynum, M. Sigalas, and A. Grot

    Agilent Technologies Laboratories, USA

    REFRACTIVE INDEX MEASUREMENT OF SINGLE LIVING

    CELL USING A BIOPHOTONIC CHIP FOR CANCER

    DIAGNOSIS APPLICATIONS 464

    X.J. Liang1, A.Q. Liu', X.M. Zhang1, P.M. Yap2, T.C. Ayi\ and H.S. Yoon1'Nanvang Technological University, SINGAPORE and2DSO National Laboratories, SINGAPORE

    TOWARD ONE: MILLION-FOLD SENSITIVITY ENHANCEMENT

    BY SWEEPINCi IN CAPILLARY ELECTROPHORESIS COMBINED

    WITH THERMAL LENS MICROSCOPIC DETECTION USING AN

    INTERFACE CI UP 467

    T. Tsuncka1, K. Sucynshi1, K. Uehiyama2, A. Hattori2, F. Kitagawa1, and K. Otsuka'Kyoto University, JAPAN and "Nippon Sheet Glass Co., LTD.. JAPAN

    XXIX

  • Poster Session Detection Technologies - Electrochemical

    METHOD OF CALIBRATION OF GLUCOSE SENSOR IMPLEMENTED

    IN AN INTEGRATED MICRODIALYSISBASED SYSTEM 470

    D. Pijanowska1, A. Sprenkels2, W. Olthuis2, and P. Bergveld2'Polish Academy ofSciences, POLAND and

    2MESA+ University ofTwentc, THENETHERLANDS

    SUB-nm SPACED NANO-POROUS ELECTRODE SYSTEMS:

    FABRICATION, PROPERTIES, AND APPLICATION TO

    SENSITIVE ELECTROCHEMICAL DETECTION 473

    U. Mailer1, J. Kentsch1, W. Nisch1, S. Neugebauer, W. Sehuhmanir,S. Linke3, M. Kaczor3, T, Lohmueller'1, J. Spat/.'1, and M. Stel/.le1'Universiicit Tiibingen, GERMANY,

    ''Ruhr-University of Bodmin, GERMANY,

    3IIL Planartechnik GmbH, GERMANY, and-1 University ofHeidelberg. GERMANY

    Poster Session Detection Technologies - Mass Spectrometry

    A FULLY INTEGRATED PLASMA ELECTRON SOURCE FOR

    MICRO MASS SPECTROMETERS 476

    J.-P. Hauschild, E. Wapelhorst, J. Muller, and M. Doms

    Hamburg University of Technology, GERMANY

    THE RAPID ANALYSIS OF SMALL MOLECULES AND DRUG

    SCREENING FROM DESORPTION / IONIZATION MASS

    SPECTROMETRY ON NANOPORE MATERIALS 479

    C.-S. Lee1, K.-K. Kang2, H.-K. Rhee2, and B.-G. Kim2'Chungnam National University, KOREA and "Seoul National University, KOREA

    Poster Session Detection Technologies - Others

    A WATER-BASED CHEMICAL MONITORING SYSTEM USING

    INTEGRATED SILICON-IN-PLASTIC MICROFABRICATION 482

    L. Zhu1, D. Meier2, C. Montgomery2, S. Sennmcik2, and D. DeVoe1'University ofMaryland. USA and

    2National Institute ofStandards and Technology, USA

    INVESTIGATION OF A RAPID MICROFLUIDIC SURFACE

    PLASMON RESONANCE IMAGING (SPRI) SIGNAL

    AMPLIFICATION SCHEME BASED ON Till- RATE, OF

    FORMATION OF AN ENZYME-CATALYZED PRECIPITATE 485

    M.S. Hascnbank, E. Fu, and P. Yager

    University of Washington, USA

    MICROMACHINED SCINTILLATION DEVICES WITH CHARGE

    CONVERSION NANOPARTICLES FOR NEUTRON AND BETA

    PARTICLE DETECTION 488

    R.K. Dasaka, S.M. Pellegrin, M. Kamavaram, and C.G. WilsonLouisiana Technical University, USA

    xxx

  • Concurrent Session 1 A3 - Elcctrokinetic Separation

    ZONE SCULPTING WITH PARTITIONED

    ELECTROK1NETIC INJECTIONS 491T.M. Squires', M. Narovlyansky2, and G.M. Whitesides2'Caltech, USA and2Harvard Chemistry, USA

    ORDERED NANOPORE CAVITY ARRAY STRUCTURED BY

    COLLOIDAL TEMPLATING FOR ELECTROPHORESIS OF

    LARGE DNA MOLECULES 494

    Y. Zeng and D.J. 1 larrison

    University ofAlberta, CANADA

    1.5 DIMENSIONAL ELECTROPHORESIS IN NANOSCALE CHANNELS 497

    S. Pennathur and J.G. SantiagoStanford University, USA

    Concurrent Session 1B3 - Droplet

    MOVING NON-CONDUCTIVE AND CONDUCTIVE DROPLETS

    IN A PARALLEL PLATE ARRAY 500

    D. Chatterjee, B. 1 letayothin, A.R. Wheeler, D.J. King, and R.L. Garrell

    University ofCalifornia at Los Angeles, USA

    USING CARTRIDGES OF NANOLITER PLUGS FOR

    HIGH THROUGHPUT SCREENING 503

    J.Q. Boedicker, B. Zheng, L. Li, D. Chen, and R.F. Ismagilov

    University ofChicago, USA

    TIMING CONTROLLABLE ELECTRQFUSION OF DROPLETS

    IN A MICROFLUIDIC DEVICE506

    W.U. Tan and S. Takeuchi

    University of Tokyo, JAPAN

    xxxi

  • Day 2 - Tuesday, October 11, 2005

    Plenary III

    MICROFABRICATION, MICROFLUIDICS, AND BIOMEDICINE:

    NEW TOOLS ANDNEW OPPORTUNITIES

    G.M. Whitesides

    Harvard University, USA

    Concurrent Session 2A1 - Cell Manipulation

    NANONEWTON FORCES APPLIED TO CELLULAR ADHESIONS

    WITH MAGNETIC NANOWIRES IN AN ELASTOMERIC

    MICRONEEDLE ARRAY._.

    509

    N.J. Sniadecki1, A. Angelouch2, J.L. Tan2, D.I I. Reich2, and C.S. Chen21

    University ofPennsylvania, USA and'Johns Hopkins University. USA

    HYDRODYNAMIC TWEEZERS: SINGLE-CELL TRAPPING

    ARRAYS FOR CELL DYNAMICS 512

    B.R. Lutz and D.R. Meldrum

    University of Washington, USA

    ACOUSTIC TRAPPING OF CELLS IN A MICROFLUIDIC FORMAT 515

    M. Nilsson1, L. Johansson2, T. Lilliehorn2, M. Lindvall1, J. Piskur1,M. Almqvist', S. Johansson2, T. Laurell', and J. Nilsson1'Lund University, SWEDEN and2 Uppsala University, SWEDEN

    Concurrent Session 2B1 - NanoChannel Fabrication

    NANOIMPRINTING OF NANOFLUIDIC CI IANNELS BY USING

    HYDROPHILIC HYDROGEN SILSESQUIOXANE (1ISQ) 518L.-J. Cheng, S.-T. Chang, and L.J, Quo

    University ofMichigan, USA

    DNA MOLECULAR ISOLATION IN NANO CHANNEL FOR SINGLE

    MOLECULE TRAPPING BETWEEN MICRO ELECTRODES 521

    M. Kumemura1, K. Tamura1, G. Hashiguchi2, and 11. I'ujita1'University of Tokyo, JAPAN and 2Kaguwa University. JAPAN

    RAPIDLY-PROTOTYPED 3D NANOELUIDICS IN GLASS 524

    S.H. Lee, K. Ke, A.J. Hunt, and E.F. Hassclbrink, Jr.

    University ofMichigan, USA

    XXXII

  • Concurrent Session 2A2 - Integrated Cell Culture/Analysis Systems

    INTEGRATED SYSTEM TO ANALYZE THE GENETICEFFECTS OF THE SPACEENVIRONMENT ON LIVINGCELLS IN CULTURE: GENESAT

    527A.J. Ricco1, E. Agasid2, V. Barker2, T. Fahlen2, J.W. Hines2, L. Levine3,R. Mancinelli2, D. Oswell1, R. Ricks2, K. Ronzano2, D. Squires2, C. Storment1,G. Swaiss2, L. Timucin2, U. Udoh1, and B. Yost2'Stanford University, USA, 2NASA Antes Research Center, USA, and3ALine, Inc., USA

    LOGARITHMICALLY PERFUSED EMBRYONIC STEM CELLCULTURE ON CHIP

    530L.Y. Kim, H.-Y. Lee, and J. VoldmanMassachusetts Institute of Technology, USA

    DYNAMIC PROFILING OF HEPATOCYTE STRESS RESPONSE IN AMICROFLUIDIC MULTI-CLONE LIVING CELL ARRAY 533K.R. King1, S. Wang2,1, D. Irimia2,3, M. Yarmush2'3, A. Jayaraman2,3,and M. Toner'•2-3'Harvard-MIT Health Science and Technolog}', USA,''Harvard Medical School, USA, and

    3Shriner Hospitalfor Children, USA

    Concurrent Session 2B2 - MicroFabrication

    AN INTEGRATED BIOPHOTONIC AND MICROFLUIDIC CHIPFOR CD4 CELL SORTING APPLICATIONS 536Y. Sun1, A.Q. Liu1, P.H. Yap2, and T.C. Ayi2'Nanyang Technological University, SINGAPORE and2DSC) NationalLaboratories, SINGAPORE

    ASSEMBLY AND PRINTING OF MICRO AND NANO OBJECTS 539T. Krausu, L. Malaquin1, E. Delamarche', H. Schmid', N.D. Spencer2,and H. Wolf1

    'IBMResearch GmbH, SWITZERLANDand2Swiss Federal Institute of Technology ETH Zurich, SWITZERLAND

    POROUS SILICON DIOXIDE CHANNELS FABRICATED FROM BLACK

    SILICON FOR ELECTROKINETIC SEPARATIONDEVICES 542

    K.B. Mogenscn, R.C. de A. Costa, and J.P. KutterTechnical University ofDenmark, DENMARK

    Plenary IV

    CONTROLLING INTERNAL ORGANIZATION AND DIVISION

    AXIS OF CULTURED CELLS WITH ADHESIVE MICROPATTERNS 545

    M. Thdry', A. Pepin2, Y. Chen2, and M. Bornens1'inslitut Curie, FRANCE and 2Laboratoire Photonique et Nanostructures, FRANCE

    XXXIII

  • Poster Session Microfluidics - Fluid Manipulation

    A GAS ACTUATED MICRO-JET PUMP FOR

    MICROFLUIDIC SYSTEMS 551

    X.H. Li', X. Yu', H. Cui2, Z. Li2, and D. Zhang''Peking University, CHINA and2Institute ofMechanics Chinese Academy Sciences, CHINA

    A PHASE CHANGE MICROVALVE USING A MELTABLE

    MAGNETIC MATERIAL: FERRO-WAX 554

    K.W. Oh, K. Namkoong, and C. Park

    Samsung Advanced Institute ofTechnology, KOREA

    A REAGENT INJECTION SYSTEM FOR STIMULATION TO

    SPECIFIC CELL COLONIES USING 3-D SHEATH FLOW SCANNER 557

    H. Mikado1, M. Kanai2, H. Nakanishi2, and S. Shoji1'Waseda University, JAPAN and2Shimadzu Corporation, JAPAN

    AC ELECTROKINETIC MICROPUMPS: THE EFFECT OF

    GEOMETRICAL CONFINEMENT, FARADAIC CURRENTS,

    AND NONLINEAR SURFACE CAPACITANCE 560

    L. Olesen1,2, H. Bruus2, and A. Ajdari11Ecole Superieure de Physique et de Chimie Industrielles, FRANCE and

    2Technical University ofDenmark, DENMARK

    CONTROL OF PARTICLE-DEPOSITION PATTERN IN A

    SESSILE DROPLET BY USING THE RADIAL

    ELECTROOSMOTIC FLOW 563

    S.J. Kim1, K.H. Kang2,1.S. Kang1, and B.J. Yoon1'Pohang University ofScience and Technology, KOREA and

    2University of Toronto, CANADA

    COPLANARDIGITAL MICROFLUIDICS USING STANDARD

    PRINTED CIRCUIT BOARD PROCESSES 566

    P. Paik1, V. Pamula2, M.G. Pollack2, and K. Chakrabarly''Duke University, USA and2Advanced Liquid Logic Inc., USA

    ELECTROOSMOTIC PUMPING THROUGH NANOCHANNELS 569

    D. Kim1, J.Y. Min2, S.J. Kim2, and E.S. Yoon1'Korea Institute ofMachinery and Materials (KIMM), KOREA and2Korea Advanced Institute ofScience and Technology (KAIST), KOREA

    HIGHLY-INTEGRATED MICROFLUIDIC CONTROL ON

    MICRO OPTICAL SWITCHING VALVES ASSEMBLED DISK 572

    PL Nagai, T. Irie, and S. WakidaNational Institutefor Advanced Industrial Science and Technology (AIST), JAPAN

    xxxiv

  • IMPROVED DESIGN AND PERFORMANCE OF AN ACOUSTICALLY

    OPERATED MULTI CHANNEL PARTICLE SEPARATION CHIP 575

    A. Nilsson, F. Petersson, and T. Laurell

    Lund University, SWEDEN

    LOCALLY CONTROLLING THE ENVIRONMENT OF A

    MICROFLUIDIC CHIP AND PROGRAMMING ITS FLOW RATES 578

    M. Zimmermann1'2, S. Bentley1, D. Juncker1, H. Schmid1, P. Hunziker2,and E. Delamarche11Zurich Research GmbH, SWITZERLAND and

    -'University Hospital Basel, SWITZERLAND

    MICRO FLUIDICS & INDUCED-CHARGE ELECTROKINETIC FLOWS 581

    F. Schonfeld'andS. Flardt1'2'Institut fiir Mikrotechnik Mainz GmbH, GERMANY and

    2Darmstadt University of Technology, GERMANY

    MICROFLUIDIC CHIP FOR MASS SPECTROMETRIC ANALYSIS

    OF MULTIPLE BIOCHEMICAL REACTIONS 584

    S.-H. Lee1, C.-S. Lee2, B.-G. Kim1, and Y.-K. Kim1'Seoul National University, KOREA and 2Chungnam National University, KOREA

    MICROPUMPING USING THIN HYBRID BIOPOLYMER MEMBRANE 587

    J.Y. Park1,1.C. Kim2, J.M. Cha1, J.H. Lee2, and B.K. Kim1'Korea Institute ofScience and Technology (KIST), KOREA and2Seoul National University, KOREA

    OPTICALLY DRIVEN MICROPUMP PRODUCED BY

    TWO-PHOTON M1CROSTEREOLITHOGRAPHY 590

    S. Maruo and H. Inoue

    Yokohama National University, JAPAN

    PERFLUOROPOLYETHERS AS NOVEL MATERIALS FOR

    SOLVENT RESISTANT MICROFLUIDIC DEVICES 593

    J.P. Rolland1, G.M. Denison1, and J.M. DeSimone2

    'Liquidia Technologies, Inc., USA and2University ofNorth Carolina at Chapel Hill, USA

    PROGRAMMING OF CAPILLARY EFFECTS FOR LIQUID

    CONFINEMENT AND AUTOMATIC FLOW CONTROL IN

    MICROFLUIDIC PROBES596

    D. Juncker1'2, H. Schmid1, and E. Delamarche1

    'IBMResearch GmbH, SWITZERLAND and 2ETHZurich, SWITZERLAND

    XXXV

  • SAW LAB-ON-CHIP IN VIEW OF PROTEIN AFFINITY PURIFICATION

    IMPLEMENTED FROM NANODROPLET TRANSPORT 599

    A. Renaudin1, K. Chuda2, V. Zhang1, X. Coqueret2, J.-C. Camart1,P. Tabourier1, and C. Druon1'IEMN, FRANCE and 2LCOM, FRANCE

    SLIDING QUANTITATIVE NANOLITER DISPENSING DEVICE

    FOR MULTIPLE ANALYSISt

    602

    M. Kuwata1, K. Sakamoto1, Y. Murakami1, K. Morishima1, II. Sudo"',M. Kitaoka1, and T. Kitamori3'The Research Association ofMicro Chemical Process Technology, JAPAN,2Toshiba Corporation, JAPAN, and'University ofTokyo, JAPAN

    THEORETICAL ANALYSIS AND MICROFABRICATION OF AN

    ALL-IN-CHANNEL CHEMICAL GRADIENT GENERATOR FOR

    CHEMOTAXIS ASSAYS 605

    D. Irimia1, DA. Geba2, and M. Toner3'Massachusetts General Hospital, USA,2

    University ofCalifornia at Berkeley, USA, and3Harvard Medical School, USA

    oster Session Microfluidics - Fluid Mechanics and Modeling

    AN INTEGRATED, HIGH FLOW RATE MEMS FERROFLUID PUMP 607

    L. Mao and H. Koser

    Yale University, USA

    COMPLEX FLUIDS RHEOLOGY IN MICROCHANNELS

    USING A MICRO-PIV TECHNIQUE 611G. Degre1, P. Joseph1, H. Willaime1, P. Tabeling1, S. Lerouge\M. Goitre3, J.-B. Fournier1, and A. Ajdari1'ESPCI, FRANCE, 2MSC, FRANCE, and 3MMC, FRANCE

    MEASUREMENT OF NANO PARTICLE CONCENTRATION

    NEAR SURFACE IN MICRO CHANNEl 614K. Kanda and M. YangTokyo Metropolitan University, JAPAN

    MILLION-FOLD SAMPLE STACKING USING

    ON-CHIP 1SOTACHOPHORESIS 617B. Jung1, II. Lin1, R, Bharadwaj1, B. Mohammad!2, and J.G. Santiago1'Stanford University, USA and ''University ofMontpellier II, FRANC 'E

    QUANTITATIVE VELOCITY MEASUREMENTS OFLAMBDA-DNA TRANSPORT IN MICRODEVICES 620S. Gulati, S.J. Muller, and D. LiepmannUniversity ofCalifornia at Berkeley, USA

  • Poster Session Microfluidics - Multi Phase Fluidics

    A MICROFLUIDIC SENSOR FOR 1NTERFACIAL

    TENSION MEASUREMENT 623NT. Nguyen, S. Lassemono, F.A. Chollet, and C. YangNanyang Technological University, SINGAPORE

    BOTH INTERNAL AND EXTERNAL FLOW FIELDS

    MEASUREMENTS IN AND AROUND A MICRO-DROPLET

    FORMED IN A MICROCHANNEL 626S.Y. Yoon1, J.M. Kim2, and K.C. Kim1'Pusan National University, KOREA and2LG Electronics, Inc., KOREA

    CONFOCAL MICRO-PIV MEASUREMENT OF INTERNAL FLOW

    IN A MOVING DROPLET 629

    11. Kinoshita, M. Oshima, S. Kaneda, and T. Fujii

    University ofTokyo, JAPAN

    GAS-LIQUID CROSSING FLOW INSIDE A MICROCHANNEL 632H. llachiya1'2, M. Tokeshi',M. Kitaoka1, and T. Kitamori3,4'The Research Association of Micro Chemical Process Technology', JAPAN,2DKK-TOA Corporation, JAPAN,

    3Kanagawa Academy ofScience and Technology,

    JAPAN, and4 University ofTokyo, JAPAN

    MONODISPERSE DROPLET TRAINS AND SEGMENTED

    FLOW FOR CENTRIFUGAL MICROFLUIDICS 635

    S. Haeberle, R. Zengerlc, and J. DucreeIMTEK. University ofFreiburg, GERMANY

    NUMERICAL ANALYSIS OF MICRO DROPLET GENERATION

    USING A PARTICLE^METHOD 638T, Harada1, Y. Suzuki2, S. Koshizuka1, T. Arakawa3, and S. Shoji3'University of Tokyo, JAPAN,

    2Japan Science and Technology Agency, JAPAN, and

    3Waseda University, JAPAN

    Poster Session Microfluidics - World-to-Chip Interfacing

    ELECTRICAL AND FLUIDIC INTERFACE OF A POLYMERIC

    MICROFLUIDIC DEVICE WITH PRINTED CIRCUIT BOARD 641

    M. Mueller1-2, M. Khine1,2, C. lonescu-Zanetti',N. Patel1, J. Seo1, andL.P. Lee1'University ofCalifornia at Berkeley, USA and

    2University ofCalifornia at San Francisco, USA

    INTEGRATED CHIP AND PACKAGE DESIGN FOR

    SURFACE-CONTROLLED BIOREACTION PROCESSES

    WITH ROBUST, REUSABLE FLUIDIC SEALING 644

    J.J. Park, T.M. Valentine, R. Ghodssi, and G.W. Rubloff

    University ofMaryland, USA

    XXXVII

  • USER-FRIENDLY ONETOUCH LOCK AND DETACHABLE

    MICROFLUIDIC CONNECTOR 647

    K. Morishima1'2, Y. Kikutani2"3, M. Kitaoka2, and T. Kitamori2'4'Tokyo University ofAgriculture and Technology, JAPAN,2

    Kanagawa Academy ofScience and Technology (KAST), JAPAN,3The Research Association ofMicro Chemical Process Technology, JAPAN, and

    4University of Tokyo, JAPAN

    Poster Session Microfluidics - Others

    MULTI-CHANNEL MICROFLUIDIC IMMUNOASSAY CHIP FOR

    SIMULTANEOUS MULTIPLE ANALYTE DETECTION USING

    ELECTROSPRAY DEPOSITION METHOD 650

    Y, Yamagata1, A. Tajima2,T. Nagamune2, H. Aoki3, II. Kase\ S. Hoshina"',I, Kondo4, and II. Ohmori''RIKEN, JAPAN, "'University of Tokyo, JAPAN, 3Fuence Co. Ltd., JAPAN, and4Jikei University School ofMedicine, JAPAN

    STATIONARY CHEMICAL GRADIENT REACTORS IN THE

    SEARCH FOR ARTIFICIAL CELLS 654

    J.S. McCaskill', S, Ehses2, S. Chemnitz', U. Tangen', T. Maeke', M. Jiinger',T. Palutke2, and P.F. Wagler2'Ruhr-Universitdt-Bochum, GERMANYand' Fraunhofer Gese/lsehaft, GERMANY

    TEMPERATURE CONTROL OF MICROFLUIDIC SYSTEMS BY

    MICROWAVE HEATING 657

    S.G. Sundaresan', B.J. Polk2, D.R. Reyes2, M.V. Rao', and M. Ciailair'George Mason University, USA and2National Institute ofStandards and Technology, USA

    Poster Session Microfabrication - MEMS

    A MICRO-POST PRECONCENTRATOR FOR A MICROSCALE

    GAS CHROMATOGRAPHY SYSTEM 660

    Y. Tang, J. Ycom, J, Han, B. Bae, R.I. Masel, and M.A. Shannon

    University ofIllinois at Urbana-Champaign, USA

    FABRICATION OF THREE DIMENSIONAL

    MICROCHANNELS IN SU8 663A. Gracias, B. Xu, and J. Castracane

    University at Albany - SUNY, USA

    FLUID-STRUCTURE TRAVELING WAVE: FILTERS BASED ONTHE MAMMALIAN COCHLEA 666R.D. White and K. Grosh

    University ofMichigan, USA

    XXXVIII

  • HIV DIAGNOSTICS FOR RESOURCE-LIMITED SETTINGSUSING MEMS BASED TECHNIQUES 669U. Demirci1'2'3, M. Dixon2, D. Irimia1'2-3, X. Cheng1-2'3, L. Zamir2,W.R. Rodriguez2, and M. Toner1'2'31Harvard Medical School, USA, 2Massachusetts General Hospital, USA, and3Shriners Burns Institute, USA

    NOVEL MATERIAL PATTERNING FOR ELECTRONIC ANDMAGNETIC COMPONENTS ON PDMS 672R. Carlson, J. Koschwanez, and D. Meldrum

    University of Washington, USA

    Poster Session Microfabrication - Micrornachining

    A NEW NEURAL RECORDING ELECTRODE ARRAY WITH

    PARYLENE INSULATING LAYER 675C. Pang, J.G. Cham, Z. Nenadic, Y.-C. Tai, J.W. Burdick, and R.A. AndersenCalifornia Institute ofTechnology, USA

    FABRICATION AND CHARACTERIZATION OF PLANAR

    NANOFLUID1C CHANNELS AND MASSIVELY-PARALLEL

    VERTICAL NANOFLUIDIC MEMBRANES 678

    P. Mao and J. Han

    Massachusetts Institute ofTechno log)', USA

    FABRICATION OF MICROPIPETTE CHIPS FOR SIMULTANEOUS

    ELECTROPHYSIOLOGICAL AND OPTICAL MEASUREMENTS 681

    A. Minamino1, K. Takahashi', T. Akagi', and T. Ichiki''2'University ofTokyo, JAPAN and

    2

    Japan Science and Technology Agency (JST), JAPAN

    Posler Session Microfabrication - Polymer Technology

    A COLLAPSE-FREE THERMAL BONDING TECHNIQUE FOR PLASTIC

    MICROFLUIDIC SYSTEMS WITH LARGE AREA MICROCHAMBERS 684

    D.S. Kim', U.S. Lee', T.H. Kwon1, and C.H. Aim2'Pohang University ofScience and Technology, KOREA and2University ofCincinnati, USA

    CHARACTERIZATION OF A NEW GENERIC 3D POLYMER

    TECHNOLOGY FOR MICROTAS 687

    P. Abgrall1, K. Chuda2, X. Coqueret2, and A.M. Gue1'LAAS/CNRS, FRANCE and 2LCOM, FRANCE

    XXXIX

  • CONSTRUCTION OF INTEGRATED MICRO- AND NANOFLUIDIC

    SYSTEMS: APPLICATION OF PHOTOPOLYMERIZATIONS AND

    BLOCK COPOLYMER SELF ASSEMBLY 690

    J.B. Hutchison, K.P. Brazhnik, and L.E. Locascio

    National Institute ofStandards and Technology, USA

    FACILE FABRICATION OF MICROFLUIDIC SYSTEMS

    USING ELECTRON BEAM LITHOGRAPHY 693

    P. Mali, A. Sarkar, and R. Lai

    Indian Institute ofTechnology Bombay, INDIA

    EMBEDDING MICROSCALE METAL PATTERNS IN

    POLYDIMETHYLSILOXANE SUBSTRATE 696

    K.S. Lim1'2, W.-J. Chang2, Y.-M. Koo1'2, and R. Bashir1;Weldon School ofBiomedical Engineering, USA and"'Inha University, KOREA

    POLYMER REPLICATED 1NTERDIGITATED ELECTRODE:

    ARRAYS AND THEIR APPLICATION IN MULTIPARAMETER

    MOLECULAR DIAGNOSTICS „ 699

    P. Jacobs', G. Van Reybroeck1, J. Suls2, W. Layreyn2, C. Van Hoof2,P. Detemple3, and R. Rossau1'InnogeneticsN.V., BELGIUM, 2IMEC Vzw., BELGIUM, and3IMM, GmbH, GERMANY

    POLYMERIC ENCAPSULATION OF LIQUID USING MICROFLUIDIC

    DEVICE AND "ON THE FLY" PHOTOPOLYMERIZATION 702

    H.J. Oh, S.H. Kim, D.J. Kim, G.H, Kwon, and S.I I. Lee

    Dankook University, KOREA

    SCALABILITY OF INSULATOR-BASED DIELECTROPHORESIS (IDEP)

    AND ITS UTILIZATION AS A HIGH-THROUGHPUT PARTICLE

    CONCENTRATOR AND SEPARATOR 705

    G.J. McGraw, R.V. Davalos, B.M. Mittal, S.M. Ferko, M.C. Hunter,J.D. Brazzle, Y. Fintschenko, E.B. Cummings, and B.A. SimmonsSaudia National Laboratories, USA

    Poster Session Microfabrication - Others

    COFIRED CERAMIC MICRODEV1CES FOR HIGH TEMPERATURE

    AND HIGH PRESSURE APPLICATIONS 709

    K.D. Patel, K.W. Hukari, and K.A. Peterson

    Sandia National Laboratories, USA

  • Poster Session Nanotechnology - Nanobiotechnology

    AMPLIFIED SINGLE MOLECULE DETECTION IN ATHERMOPLASTIC MICROFLUIDIC SYSTEM 712J. Jarvius, J. Melin, J. Goransson, H. Johansson, F. Nikolajeff, U. Landegren,and M. Nilsson

    Uppsala University, SWEDEN

    COMPLETE EXTENSION OF CHROMOSOMAL DNAAND ITS MANIPULATION USING OPTICALLY-DRIVEN

    MICRO-FABRICATED HOOKS 715K. Terao1, H. Kabata2, H. Oana', and M. Washizu1'University of Tokyo, JAPAN and2Kyoto University, JAPAN

    SPECTRAL AND MOBILITY MEASUREMENTS OF SINGLE

    FLUORESCENT NANOBARCODES IN SUBMICROMETER

    FLUIDIC CHANNELS 718S. Stavis, J. Edel, Y. Li, K. Samiee, D. Luo, and H.G. CraigheadCornell University, USA

    DNA SAMPLE PREPARATION FOR STM/STS

    BY NANOLITHOGRAPHY 721

    S. Horiike, Y. Oikawa, and T. NishimotoShimadzu Corporation, JAPAN

    FABRICATION OF CUSTOMIZED BIOACTIVATED

    NANOPORE DEVICES 724

    A.H. Talasaz, D. Pantelis, M. Ronaghi, F. Pease, and R. W. Davis

    Stanford University, USA

    MANIPULATION OF COILED DNA MOLECULES BY FORMATION

    AND LASER TRAP OF THERMOREVERSIBLE HYDROGEL 727

    F. Arai, K. Yoshikawa, A. Ichikawa, H. Maruyama, and T. Fukuda

    Nagoya University, JAPAN

    Poster Session Nanotechnology - Nanofluidics

    SIMPLE AND QUICK DETECTION OF TARGET DNA BY

    HYBRIDIZATION IN NANO GAP CHANNEL ARRAY 730

    S. Hashioka, R. Ogawa, A. Oki, Y. Miyahara, and Y. HoriikeNational Institutefor Materials Science, JAPAN

    SIMULATION OF ELECTROKINETIC TRANSPORT IN

    SILICA NANOCHANNELS 733

    S. Joseph, A.N. Chatterjee, and N.R. Aluru

    University ofIllinois at Urbana-Champaign, USA

    xli

  • WATERVISCOSITY AND HYDRODYNAMIC FLOW

    IN NANOPILLAR CHIPS 736

    N. Kaji', A. Oki2, R. Ogawa2, Y. Horiike2, and Y. Baba1'3'Nagoya University, JAPAN, ~National Institutefor Materials Science, JAPAN, and3National Institute ofAdvanced Industrial Science and Technology, JAPAN

    Poster Session Nanotechnology - Nanoengineering

    CONTROLLABLE NANO-GAP MECHANISM FOR

    CHARACTERIZATION OF NANO-SCALE OBJECTS 739

    M. Gel1, T. Edura2, Y. Wada2, and H. Fujila1'

    University ofTokyo, JAPAN and"' Waseda University, JAPAN

    MAPPING THE LIGHT EMERGING FROM NANOSCALE APERTURES 742

    S.C. Jacobson, N.D. Rawlinson, D. Amarie, M.L. Kovarik, W.L. Sehaieh,

    and B, DragneaIndiana University, USA

    Poster Session Materials & Surfaces - Surface Modification

    A SIMPLE HYDROPHIL1C TREATMENT OF SU-8 SURFACES FOR

    CELL CULTURING AND CELL PATTERNING 745

    Z. Wang, M. Stangegaard, M. Duiva, J.P. Kulter, and A. WolffTechnical University ofDenmark, DENMARK

    EFFECT OF SURFACTANTS ON ELECTROOSMOTIC FLOW AND

    TRAPPING BEHAVIOR IN A POLYMERIC INSULATOR-BASED

    DIELECTROPHORETIC (iDEP) DEVICE 748G.J. McGraw, K. Lee Krafcik, T.I. Wallow, M.C. 1 lunter, A.M. Morales,R.V. Davalos, Y, Fintschenko, E.B. Cummings, and B.A. SimmonsSanclia National Laboratories, USA

    ELECTROPHORETIC PROTEIN SEPARATION USING

    ELECTROOSMOTIC FLOW INDUCED BY DYNAMIC

    SDS-COATING OF PLASTIC CHIPS 752

    H. Nagata', M. Tabuchi2, K. Hirano', Y. Baba1'2-3, and M, lshikawa''National Institute ofAdvanced Industrial Science and Technology (AIST), JAPAN,2University ofTokushima, JAPAN, and3Nagoya University, JAPAN

    INTEGRATED CIRCUIT AND MICRO-FABRICATION

    COMPATIBLE MATERIALS FOR PROTEIN BINDING 755

    M. Anwar1, T. Aytur2, J. Foley2, P.R. Beatty2, and B. Boser'Massachusetts Institute ofTechnology, USA and \2

    University ofCalifornia at Berkeley, USA

    xlii