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CONTENTS

NotefomtheCEO

2010Hghghts

CEllECTiSiNbriE

Oucoectvty

CEllECTiSiN2010

Ouscence

busnesseveopment

Copoteeveopment

Humnresouces-Communctons

SbSidiariES

Ceectsoesech

Ceectspntscences

Ectyce

Ceectsthepeutcs

iNaNCialSTaTEENTS

aPPENdiCES


3/27

4 l Ceectsl actvtyrepot2010 l 5

Gowthneveopment

Wemesevecqustonsn2010,offengusthepomseofnewtechnoogc

nnovtonsnoostngounteectupopetypotfoo.inSepteme,foexmpe,

wepuchsethessetsofCytoPuse,compnythtspeczesneectopoton

systems,technquethtweneustontoucemegnuceses,oothemoecues,

ntowengeofffeentcetypes.Wesoecetopusuetheptneshpsunche

yCytoPuse,menngthtweenpostontoenetfomtheopetngcenses

gntefoeectopotontechnoogy.Onestnofoueveopmentsttegysseon

thecqustonoftechnoogesthtcompementougenomeengneengtechnoogesncneusefoongeofppctons,fomesechtothepy.inthepusutof

thsm,wehvesocquenon-excusvecenseghtsthtoffeusccesstonuce

pupotentstem(PS)cetechnoogyesutngfomthewokofKyotonvestysPofesso

ShnyYmnk.Ceectssthestcompnynthewotosecuecensesfohumn

thepeutcopophyctcppctonsunethspotfoonwemkngthese

technoogesvetotssusyEctycesothttcnecomeenggopye

nthse.

innovtonnpefomnce

Wehvemeconseepogessnoukeyusnesssectosthsye,othntemsof

scencenpoucteveopmentnntheeofnteectupopetynsesctvty.

itgoeswthoutsyngthttheesstottoeone,nwehvenotyetcheve

ougos.Howeve,weemoeconvncethnevethtwepossessneffectveeconomc

moentechnoogeswththepotenttomkecmpct.Ousuccesssune-

pnneythepeopewhomkeupougoup,ouesouces,oucutueofexceencen

ouvsonoftheotechnoogynusty,whchtogethehvemetpossefoustou

goupongosce.

d.anChouk, Chie Executive Ofcer

Weevngnnethtseenngtheveyessenceofotechnoogy.Thecoeconcept

ofotechnoogysseonusngvngognsmstotnsfompouctsymensof

nustmethos.Thsnotonwsevoutonzenthete1970swththescoveyof

ecomnntdNanthepouctonofthepeutcpotens,eveopmentsmeposse

youtytomofydNafgmentsntesttuesnentoucethepouctsofths

engneengpocessntoces,theeychngngthegenetcmkeup.Wehvenoweche

newstgenthsotechnoogcevouton.Chngngthegenetcmkeupofcessno

ongeowntochnceutspefomeusngtonmethos.ascpneoncechcteze

ygenetcmnputonsesutngfommkeshfttnkengwthvngognsmshsnowecomenchofengneengscence.dNapogmmngnowusespefect

knowegeoftheentegenomesequencetootnpecte,eenexctesut.

asentevouton

Pectonsntheeofotechnoogyeoftenoptmstc.butthespeetwhch

scentstshveeenetoecoethedNaofthehumngenome,nthedNaof

vngspeces,hsconstntysupssepectons.Toyweetthecuspofnew

enwhchgenetcnfomtonwevetoeveyone.itsestmtethty2013,

thecostofecongthehumngenomeweessthn1,000euospepeson,

nthepocesswepossenunefouweeks.injustfewyes,monsofpeope

whvethegenomeecoeneetousettoesgncustomzemec

tetments.Genomeengneengsstuteownstemofthswve.Thetechnooges

eveopeyCeectswmketpossetotetnnteocquegenomcefects.

Genomeengneengwgenetehostofnew,nnovtvepoucts,tkngupthe

tochfomfossnchemcesouces.Thesenewesoucesfomvngognsmsoffe

vstpotentfogowthnsustneeveopmentovethecomngeces.

leengenomeengneeng

Ceectssnstongpostonnthsemegngnustsecto.Weeveopnewcssesofthepeutcpouctswththepotenttotnsfomthewynwhchsesese

tetentocuesesesthtecuentyncue.Wesoeveoppoucts

foesech,ophmceutcpoucton,gootechnoogy,nucestemcesn,

moeecenty,ntheeoftentvefues.Ouppochtootechnoogyspose

tongfunmentchngestothsnustynthecomngecesntooffen

enesssouceofnnovtonngowthfoousocety.

NOTErOTHECEO

2010yeofconstucton

l Ceectsl actvtyrepot2010 l4


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l Ceectsl actvtyrepot2010 l6 l Ceectsl actvtyrepot2010 l 7

2010HiGHliGHTS

CeectsntheenchNtoninsttute

foagcuturesech(iNra)sgn

coopetongeement

CellectsniNrawshetocollbote

ntheelsofcellbologynplnt

nnmlbotechnologes.They

ecetopooltheexpetse,whee

possble,tocquenewscentc

knowlege,tocetetechnologcl

nnovtons,ntoshethese

esults,knowlege,ntnsfetechnologytobusnesses,ptcully

tosmllnmeum-szeentepses

nthegofoo,gcultuen

envonmentsectos.

CeectsecevesiNPiNton

innovtonaw2009

CeectswonNtoninnovton

awfomtheenchNtoninsttute

foinustPopety(iNPi).Ceects

iPngechePqueeceve

thewfomthePesentofthe

iNPibo,Theyon.Thews,

ognzennuyytheiNPisnce

1991,honosmnmeum-sze

entepseswhosegowthcnett-utetotheoutstnngnnovton

pocesnwhchusecompehensve

nteectupopetysttegytoevege

usnessgowth. Cellectis represents a

fne balance between research activities

and a healthy management strategy,

sTheyon.

CeectsunchesCeectspnt

scences,susyecteto

pntppctons

Themnmsofthssusyeto

ncesencceeteusgeofCeects

popetytechnoogyngcutu

oogy,oenthecompnyssks

setottctnewnexpne

censngoppotuntesnexpoethe

eveopmentofpopetyttsfo

seecteppctons.Ceectspntscencessoctennnepos,

nnesot,Sa,wthotoyspce

cosetothenvestyofnnesot

ntsgeenhousefctes.itsChef

ScentcOfce,PofessodneVoyts,

cuentydectoofthenvesty

ofnnesotCentefoGenome

Engneeng,snntentony

enownescentstnestshe

expetnpntgenomeengneeng.

Newjounpuctonets in vvo

ctvtyofCeectsmegnucesesn

muscees

resechestthelvnvesty

HosptCentenQueec,Cn,

usemegnucesesengneeey

Ceectstoestoetheexpessonof

mcoystophnnhumnmyosts

in vitronnmuscees in vivo.

Theyweetheefoeetoshowthepotentofusngmegnucesesto

tetduchennemuscuystophy,

heetysesethtschcteze

ypegenetonofthemusce

tssue,eventuyengtoossof

motyneth.Theesutsofths

esechweepushenthescentc

jounGene Therapy.

Ceectsoesechnlonz

enteeveopmentncommec

mnufctunggeement

Ceectsoesechnlonz,wo

eenotechnoogymnufctue

hveenteentocontctfothe

eveopmentnmketngofoeng-

neeecenes.Ceectsoesech

wusetsmegnucesestonctvte

(knock-out)thegutmnesynthetse

(GS)nCHOK1SV,lonzspopetyhostcene.Johnbch,CSOof

lonzbophmceutcs,s,Lonza

is delighted to work with Cellectis

bioresearch. This collaboration makes

sense and will enhance our long-

standing and successful GS technology.

Newstuyshowsmegnucese-ven

tgetentegtonusngCeects

oesechscGPSCHO-K1kttoe

hghyefcentfougscovey

Scentcesechseonunque

methofogenetngstecenes

comptewthhghthoughput

sceenng(HTS)wspushenthe

Journal o Biomolecular Screening.

Thsesechshowethtthetechno-ogyeveopeyCeectsoesech,

seonmegnucese-ventgete

ntegton,sfste,moepctc

nmoeefcentthntton

methosnevngce-sessys

foHTSstues.

Jnury

Jnury

rc

h

apri

l

June

July

6

Styzemegnucese.


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Ceectscquesssetsfom

CytoPuseScencesinc.

CytoPulsespeclzesntheevelopment,

mnufctuenmketngofelecto-

potontechnologynequpment.

Electopotonshghlyefcentwy

fomoleculessuchsmegnucleses

tobentoucentonytypeofcell,

wthpplctonsngngfomesech

nbomnufctungtogcultue

nthepeutcs. CytoPulses assetsare a great strategic acquisition for

Cellectis,sCellectsChefExecutve

OfceanChoulk.

As we announced in 2009, part o

our development strategy is to acquire

technologies that complement our

existing meganuclease platorm and can

be leveraged across all aspects o our

business, rom research to therapeutics.

We saw such an opportunity in the

technologies at CytoPulse Sciences

Inc. and look orward to unlocking the

value o these assets.

Ceectsoesechnnounces

vtyofesechktsthoughnew

onneonne-stoe,povesenhnce

ccesstytomegnucesetechnoogy

Ceectsoesechnnouncethe

unchoftse-stoe,wthppoxmtey

onehuneey-to-usepoucts

vefoseonnevnewfunc-

tonnntutvewestetomeetthe

neesofothcemcnnusty

esech.The launch of a website withonline purchasing capability was a vital

step in improving researchers access

to our meganuclease technology,

expnelucSeg,VPSesn

ketngtCeectsoesech.

Our product oering has expanded

rapidly, and we now market over

one hundred dierent products on

three target markets.

Ceectsunchestsnewcopote

weste-infomtonshng,ntectvty

nnewmespce

Vstostothenewwesteeensue

enhnceustynnfomton

shng,ncungmoestemne

ccesstonfomtonoutCeects

technoogynpoucts.

ThenewCeectswestefocuseson

theecentthemes:esechntechnoogy,usnesseveopmentn

nvestoetons.

Ceectsoesechnnounces

estshmentofsusyntheS

loctettheCmgeinnovton

CentenCmge,sschusetts,

Ceectsoesechinc.weesponse

fotheS-wepomotonofCeects

oesechpouctsnsevces.

Ceectsn-censesnucepupotent

stemcetechnoogyfomPS

acemJpnstptentcense

nthethepeutce

Ceectsenteentotwoseptenon-

excusvecensegeementsgntng

thecompnywoweccesstothe

nucePupotentStem(PS)ceptent

potfoosngfomthewokof

PofessoShnyYmnkttheCente

foPSCeresechnappcton(Cra)tthenvestyofKyoto,Jpn.

Ceectssthestcompnynthewo

toecenseyPSacemJpnto

usethsptentpotfoofoppctons

nhumnthepeutcsnpophyctcs.

intheesechtooe,thssthe

stgeementwthenchcompny,

foownggeementswthSn

Gemncompnes.

CeectsgntsHvboscence

censetoCytoPuseeectopoton

nstuments

CeectsnHvapptus,vson

ofHvboscenceinc.whcheveops,

mnufctuesnmketso

ngeoftoostovncefescence

esechnegenetvemecne

wowe,sgnecensegeement

thtgntsHvapptusthe

woweexcusveghttomnu-fctuenmket,foesechuse,

thefuneofeectopoton-se

nstumentscqueyCeects

fomCytoPusenSepteme2010.

Ceects,howeve,etnsghtsto

theuseofthesenstumentsfotsown

esechneveopmentpogmss

wesncnctsnpophyctc

othepeutcpoceues,footh

humnsnnms.

Septem

ber

Septem

ber

Septem

ber

Octo

ber

Octo

ber

decem

ber


6/27


CEllECTiSiNbriE

Thecompnyesgnsnmketsnuceses

odNascssossuchsmegnuceses,

nnovtvetooswhchenepecse

moctonofthegenome,swes

othepouctssngfomthstechnoogy.

Ceectsmstoexpotthefu potent

oftstechnoogynmecnenothe

esofscentconustexpoton.

Sncetsnceptonn1999yanChouk,

Phd,ndvSouve,Phd,Ceectshs

enjoyeexcusveghtstoptentpotfoo

owneytheinsttutPsteu.Pofessoroney

rothsten(Coumnvesty)chsts

Scentcavsoybo,whchcompses

ntentonyenownescentsts.

Tote,Ceectshsenteentomoethn

50geementswthphmceutco-

toes,seepoucesnotechcompnes

wowe,nhsfomemoethn20

cemcesechptneshps.

Snce2007,Ceectshseensteonthe

NYSE-EuonextatenextmketnPsn

hssecueove70monncptsnce

tsncepton.Whemntnngtsmtous

gowthtgets,Ceectshsveyso

cshnceuetonceseevenuefom

pouctses,megnucesepoucton,

ptneshpsncensegeements.

Wth10yesofwokonmegnuceses,

Ceectshscqueunmtcheexpetsen

theeofgenomeengneeng.Thenten

r&dnmegnuceseptfomtemshve

oknowegeoftheenthesks

equetoseectnntegtenewtech-

noogesthtwoupovecompementyto

Ceectsoffeng.

CEllECTiSiNbriE

Worldwide pioneer in genome engineering

Estshen1999,steontheNYSE-

EuonextatenextmketnPssnce

2007(alClS)

2010 operating revenues: 15,8

Staff: 129ncung51Phds

4 subsidiaries: Ceectsoesech,

Ceectsthepeutcs,Ceectspntscences,Ectyce

Applications: esechnomnu-

fctung,humnheth,gcutu

otechnoogy,stemces

Main technologies: genomeengneeng,

potenengneeng(nptcunuceses

odNascssos)

IP portfolio: 83ptentsgntenmoe

thn260ptentppctonspenng

Locations :Ps(nce);SntPu,

nnesotnCmge,sschussetts

(Sa)

As o December 31, 2010

Ceectsmpovesfeyppyngtsgenomeengneengexpetsetoongeofppctons,ncunghumnheth,oesechngcutue.


7/27


egnucesesentupotensfounnmnysnge-ceeognsms.Theyehghy

speccdNascssos.Theyeetoecognzethenngsteyentfyngnucec

csequence(nuceccsetheconsttuentsofdNa),whchcontnsetween12n

ove30seps.Thsstessttstcyunquengenome.OncethedNaekhseen

me,thecectvtestsmntenncenepsystem(foexmpe,homoogousecom-

nton).ThssystemcoectsthedNamoecueyusng,foexmpe,tstwncopy(gene

coecton)osmfgmentspeccyntoucentothecesmoe(nsetono

knock-n).itsthesmepncpesthecopynpstefunctonnwopocessng.

Whengenejustneestoenctvtethethnepce,theokendNasounn

osesnfomton,theefoethetgetegenesnctvte(knownsknock-out).

Ceectsmnufctuesmegnucesesthtcncutpecsenewsequences,nethusto-

mefogenesofnteest.Thefestyofmegnuceseengneengowstheceton

ofwengeofspecctoostomofythetgetegenes.itsthetechnoogcvson

uponwhchCeectswsfoune11yesgo.Thswschevewhenthemegnucese

ptfomwsetopoucecustommegnucesespeccofnynewgeneofnteest,

wththesmechctestcssthewtypeones(efccy,speccty,).Thsexpetsen

genomeengneengtoospouctonhsoweCeectstoevovefomtoopouceto

pouct-evengcompny.

Genetcshsemonsttethelnkbetweenthephysclttbutesofspecesnthe

genes,ntheebyshownhowptculgenesemplctencetnsesesott-

butes.Genomeengneengenblesspecesgenestobemoenoetochngecetn

ttbutes,toectfyneo,otonewttofphysologcloeconomcnteest.

Thsppochsnotnew:coss-beengffeentplntsoselectngthebestnmlsfoepouctonsbseonthesmepncple.Themstompovespecesbygvngthem

thebestpossblettbutesoughttolenceopestesstncefocops,foexmple.

Thetgeteppochofgenomeengneengspecte,moeeenmoeeffectve

thneetechnques,ncneveneppetohumns.Thegenomesofove1,000

ognsmshvenoweenecoe.Knowegeofthesequencenoctonofthegenesof

vngengsstheefoeconstntympovng,eventhoughthewokngsofthesegenese

stnotfuyknown.Ouunestnngnthseowsustomnputegenesecty.

Theeetheepossesttegestooths:

insetonsusetonewttutetothegenome.oexmpenugscovey,

onoetoovecomegenetcefectkehemoph.

Coectonsusetoepcenexstngefectvesequence(whchgeneympctsthe

genesfunctons)yfunctonsequence.oexmpe,totetseousgenetcsese

suchsduchennemuscuystophy.

inctvtonsusetopeventtheexpessonofgene.Thsppochcneusetotet

pesstentvnfectonssuchsaidSohepes.

Outoo:egnucesesCompewtheetechnooges,theeffectvepoweofgenomeengneengesnts

tytonsetthegeneofnteestnthechosenpce.omnyyes,esechesmethos

weekntopyngtsnfoe.Theywoustuytheeffectofnomynsete

sequences,esptethefctthtnsetonnthewongpcecnhvehmfueffects:one

genecnensetentonothennctvtet,octvtecncemechnsms.Thss

wheeCeectshsthecompettveege.itsexpetsenmegnucesesmensthttse

topecseytgetspeccocusnthegenome.Ceectstoosgvescentststhepecson

theyweeckng.

Thepncpeofgenomeengneengssmpe:tnvovesmofyngthegenomeofnnvuospecesfothepuposesofunestnngthewytwoks,poucngusefupotensotetngsese.

egnucese

Chomosome

cut

OrCOrEaCTiViTY:GENOEENGiNEEriNG

Geneinseton

KNOCKiN GENErEPair

Geneinctvton

KNOCKOT

pastepaste

loss o a ewbase pairs

NonHomoogousEnJonng(NHEJ)

epmtxintegtonmtx

Homoogousrecomnton

Homoogousrecomnton


8/27


OrCOrEaCTiViTY:aPPliCaTiONS

HumnhethGenomeengneengsthessfogenethepy.Oftencegenomesugey,ths

typeoftetmentcoueusetocuemnygenetcseses,suchssckecenem

(epnocytoss).resechnthsehseenceoutncootonwthCeectst

theemoSon-KettengCnceCentenNewYok.insem,theCNrS,na

(enchassoctongnstmuscuystophy)esocoseynvovenCeectspogess

nthethepeutce.butgenomeengneengcnsoeusetoghtvuseskehepes.

ThesepthogensnsetthedNantothedNaofnfecteces,menngthtthe

mmunesystemsunetogetofthempemnenty.Ceectstytotgetvey

pecseegonsofvusesgenomenoetonctvtethemmghtmketposse

toemovethegenetcmteofthevusesfounnthenfecteces.Thstheefoeepesentspotentekthoughnthetetmentoftheseseses.

agootechnoogyegnucesescneengneeesothttheyespecctonygeneofnyspecesof

pnt.Ceectsuseststechnoogynexpetsetopoveseepouceswthmeg-

nucesesthtcnmketgetemoctonsnpntgenomesntoeveopthenext

genetonofhghqutycoppnts.ToyCeectsseveopngptneshpgeements

wthsomeofthemjopyesnthegootechsecto,sothtgenomeengneengw

ecceptenweyusewthnthseofppcton.in2010,CeectsceteCeects

pntscences,susyectetogenomeengneengppctonsnpnts.itsm

stoncesencceeteusgeofCeectspopetytechnoogyngootechnoogy

ntoeveoppopetyttsfoseecteppctons.

resechnomnufctungGenomeengneengstthessofthemoenppochtofunmentesechn

oogy.Theentehumngenomesequencehseenente,swesthoseofmoe

thnthousnspeces.Howeve,oogstsonotknowtheenteoeofthesegenes

ththveeenente.Tonouttheoeofthesegenes,wecnusetgetedNa

moctontechnquestosuppessoegutetheexpessonofpecsedNasequence.resechescntheefoeunestntheoeofgeneystuyngtheeffectsoftssence

ovtonsntsexpessonotsstuctue.inomnufctung,megnuceseppctons

hveunquecompettvevntgesntemsofmnufctungpocesses,euctonncyce

tmenmpovementsnpotenquty.resechktsemketeyCeectsoesech

owngmegnucese-ventgetentegtonofgenentovouscenes.

TheymketesefoesechestomofythedNaofspecestheyestuyngn

fomnufctuestosceennevutethepouctsefcency.

resechtems

Xoot,dNapouctonnptesQpxoot,megnucesestesteontgets

Theptfomtemntsoots

Cooetestfomutntseecton

dNaunvestymkestpossefooutechnoogytoeppetonyknofspeces(humn,nm,pnt,cte,ov)ntoeveygeneofnteest.ThetechnoogyconcevenmsteeyCeectscneusetounockoestoethepotentofdNa,openngupongeofppctons.

OraCiliTiES


9/27

l Ceectsl actvtyrepot2010 l16

OrGaNiZaTiON

CEllECTiSiN2010

oususesofCeectsweeceteetween2008n2010.Themstofuyeveoptheppctonsofoutechnoogywthnthegvenmketsectos.Thepentcompnycentzesthennceptmentofthegoup,thenteectupopety,theegeptmentnothesuppotfunctons,swestheesechneveopmentoungenomeengneengtechnooges.ThedNascssosptfompouctonwemnthesttegccenteofthecompnyswhoeswesthevngfoceofthegoupctvty.

Cellectis and its subsidiaries

Ectyce

EctycewsestshenSepteme2009toesechncommeczenust

usesofstemces.

Thentgosetoeveoptoosfogenetng

nucepupotentstemces

fomutces,oust,epouceffeenttonofstemces,nceesfotestngugcntes.

Ceectsoesech

ounen2008,Ceectsoesecheveopsn

mketsesechnpouctonktsthtmke

genomeengneengccessetooogc

esechesncompneswowe.

itoffestunkeysoutons,enngoogststoesgn

theywoktooswthcontonpecson,

suchsceneswththefetuesofhethy

oseseognotssue.

Ceectspntscences

Estshench2010,Ceectspntscences

ssusyectetotheppctonsof

megnucesestopnts.itsmnmssonstoncese

ncceeteusgeof

Ceectspopetytechnoogyngcutuoogy,oenthe

compnysptfomtottctnewnexpne

censngoppotuntesnexpoetheeveopment

ofpopetyttsfoseecteppctons.

Ceectsthepeutcs

Ceectsthepeutcs,unchen2008une

thenmeCeectsgenomesugey,sectetotheeveopmentofnnovtvethepeutcppochesusng

megnucesestotetgenetcseses,cncesn

pesstentvnfectons.Ceectsgenomesugeyseekstotetptents

suffengfomseoussesesesstnttoconventon

tetment.itspospectvethepytgetsthevey

dNasequenceesponsefothesesethtmye

ofcongentogn(genetcesese)ocque

(vnfectonocnce).

Ceects

Technoogeseveopment,potenpouctonptfom,nteectupopety,suppotfunctons.

17l Ceectsl actvtyrepot2010 l


10/27


OrSCiENCE rESEarCHaNddEVElOPENT

d.cPques,ChefScentcOfce

Thschevementesutefompope

nustztonofoupocesses,whch

usttestheovemtutynpt-

tyoftheognzton.Thsenhnce

pouctoncpctymensthtCeects

cnpostontsefssuppeoftoos

foveyospectumofppctons

npoucts.

butthepogessththseenmen

oumnufctungpocessesshounotoveshowthevncesmenthe

ppctonofoupoucts.Oneofthe

mostsgncntchevementsstheuseof

oupouctsngenomesugey,whchs

nowhppenngonnunpeceentesce,

wthove15cootonswthcemc

esechsovethewo(HSr-TiGET

nn,Vibnleuven,ChenHospt

nboston,)poucngoth in vitron

in vivot.Thsepesentsgete

numeofmegnucesesuseswes

oevetyofppctonmethos,

ptcuythecetypesthtcne

successfuytgete.bothspectse

ectynketothencesenou

mnufctungcpcty,whchsmeetng

thegowngneesofoucustomes,

ouptnesnoun-houseesech

neveopmentctvtes.

in2010weuseozensofmegnucleses

nmmotlzecells,plnts,nmlmoels

nstemcells.Thsbopplcbltys

keyfetueofthepotentlofCellects

technology.Themountoftgthee

byffeenttems,bothtCellectsn

elsewhee,snctveoftheobustness

ofthstechnology.nyoftheseesultswll

bepublshethoughout2011.

ny,ouesechhseneustossessthechengesthtehe,ptcuy

n2011nntsthethepeutcsecto

whchhossomeoftheggestchenges

fous.amongthem,thetytogetou

moecuesnsufcentnumesntothe

tgetceswemjopotyfoou

esech.anothekeypotysensung

thesfetyofthsppoch,whchsecty

nketothespecctyofthemegnuceses.

Thespecctycteethemoststcty

ppenthepeutcppctons,

nsfetymoststngentyssesse.

Sfetynvectozton(othemetho

usetonsetmegnucesentotget

ce)etheefoethetwokeywos

fo2011,swespentheyefocusng

whoeheteyontheppctonsof

genomeengneeng cossesechtoos,gcutueomecne.

d.cPques

ThecoectvtyofCeectsntenr&dtemstoengneemegnucesesthtespecctochosendNatget,.e.tocetecustommegnucesesfoechgeneofnteest.

ThetemstCeectscnentfytheesesponsefothedNascsso

functonwthnthemegnucesestuctue,

swestheesthtcoesponto

theecogntonofspeccdNastes.Ou

esechesetheefoeetomofy

theecogntonndNaxtoneso

stogenetenewvntsthttgetnew

stesngenome.asesutofthsesech,

Ceectsnowhsgenkofpotens

wthove40,000motfsthtcne

comnetootnchmecpotens

cpeofnngtoffeentsequence

comntonsofthedNa.

inthelbstCellects,upstemesech

sspltntotwoes.Onetemof

esechesfocusesontheengneengof

potensmegnuclesesnptcul

noetompovethectvtynspec-

cty,ntoncesethesequencespce

thtcnbetgetebythesetlo-me

megnucleses.Theothetemfocuses

onthectvtyofmegnuclesesncells,

nptcullyonmpovngtheefcency

ofgenetgetngntsecombnton.Thstemslsowokngonnewppl-

ctonsfomegnucleses.

in2010,ther&dgoupmempotnt

pogess,ncungtheentctonof

newpotenstuctueswththecpty

toeengneeemoequckyn

offengnewpopetes.Thsetonew

megnuceseswthoptmzeusge.

aveycompetepucton,whch

escestheffeenttoosusen

genomeengneengncompesthe

popetes,wspushenCurrent Gene

TherapyytheCeectsesechtemt

theenof2010.

Meganucleases and other Tools for

Targeted Genome Engineering: Perspectives

and Challenges for Gene Therapy

SvG,Pootl,Gettor,SmthJ,

ontoyG,duchteuP,Pques.

CuGeneThe.2010,dec24

2010wsptcuypouctveyentemsoftheesechnvncementofoucoetechnoogy.Oneofoumnchevementswstheconsotonofoupouctonptfomnoetopouceeconumeofmegnuceses(271n2010).


11/27


PrOdCTiONPlaTOr

Thescentstsentfythepotenmoues

whosedNatgetsmtchwthfgments

fomthetgetegenomeste.Thenthey

comnethemouestocetenew

megnucesewthecogntonspeccty

fotheequegenetget.Thectvty

ofechnewycetemegnuceses

thentestenseesoffunctonts

eveopeyCeects.

athecetonnnysswoksceoutythepouctonPtfomtem,who

cetefomstttonshtheenzymes

usensoyCeects.ThePtfom

temceteshghqutymegnuceses

compntwththepecsespecctonsof

echCeectsptneocustome,nten

nexten.ThePtfomtemcn

vtensecueoesysuppyngech

customewthsoutonthtestmeetsts

nees.sngtsyofoots,thePtfom

temsetomesuethectvtyof

vstnumeofmegnuceses.itsctuy

etounupto1montestspeweek.

Thesetethenpocesse,nyze

nusetoesgnmegnucesesthte

ppoptefoechpoject.ThePtfom

temenestheesecheptmentsto

ssessthetheoesnstnpouctoncontonswhefoowngstctpoceues

thtgunteefusmpetcetyn

quty.Thswokssuppoteyo-

nfomtcstemthtsuppesessentt

totheesechtems,enngthemto

pectthecoectstuctuesfoeveopng

effectvemegnucesesntheshotest

possetme.

bycyngouttsesechwok,the

Ptfomtemsetoexpnthe

tse,enhncngCeectsknowege

nscentcexpetse.2010wsmke

yeuctonnstztonn

mnufctungtmeswthnthePtfom.

Thsesutensgncntncesen

oupouctonoutput,wth271meg-

nucesesmnufctuen2010compe

wth99n2009.

atCeects,themssonofthecomputtonoogytemstopouceengneeemegnucesesusngtonppoch.

Newmegnucesesetoyessenty

pouceyso-cesem-ton

ppoch:coectonsofmegnucese

vntseutynomymofyngspeccesofthepoten,nthese

coectonsetesteytheptfomto

entfythemutntswththeexpecte

popetes.Stvngfotonppoch

mstetemnng,wthmoepecson,

whchvntsemoekeytoe

functonnoetogenetentest

smenumeofthesevnts.

TheCeectscomputtonoogypogm

mstompovePtfompefomncen

temsofevey,cost,cpcty,sequencng

enpouctquty.Theehseen

egupogessnthestfewyesn

wththeuseofnnovtvenewtechnques

ecentympementetCeects,wecn

etteessthecoepefomnce

mpovementmofcomputtonoogy.

Computtonesgnnvovesusng

softweseonenegyeveccutons

npoten,ncompeteyeesonthe

vtyofstuctut(.e.tmen-

sonstuctuesofmegnucesesoun

tothedNatget).Ceectsestshen

2009-2010ectecomputton

oogygoup,npewththesetup

ofmjostuctuoogypogm.

ThepogmshettheCNiO()

ncootonwthdGuemoontoy.Excusveccesstosgncntmountof

stuctuthseenkeyfctonthe

computtonoogygoupgnngette

unestnngofthemechnsmsgovenng

megnucese/dNantectons,n

optmzngthemoecumoengpocess

nguyepcngtheexpement

hgh-thoughputsceenngmetho.

antceescngthewokofCeects

onmegnucesesnthetechnques

usetocetenpoucenewpotens

thtcncutnewtgetswspushen

Novementhejoun Protein Engineering

Design and Selections.Thstceso

escestheongeofppctons

ofmegnuceses:eveopmentofce

nesenngpotenexpesson,moe

pntsnnms,thepeutcsppctons

kegenethepy,ocetonofnew

cssofntvugs.

The I-CreI meganuclease and its

engineered derivatives: applications from

cell modication to gene therapy

anouS,deenC,GzotS,

desseuxC,Pques,SvGH,SmthJ.

Protein Eng Des Sel. 2010,Nov3

Pnt:2011Jn.24(1-2)pp27-31

antcewspushenthescentc

jounNucleic Acids Research,esutng

fomcootonetweenCeectsn

d.Guemoontoysotoytthe

CNiOof.itescesthestuctueof

megnuceseountotsdNatget.

Molecular basis of engineered mega-

nuclease targeting of the endogenous

human RAG1 locus.uoziG,PetoJ,SumnnS,

CoomJ,reonoP,Vte,enoN,

enchno,damo,Gevsol,

GzotS,douss,SmthJ,Chon-Sotnei,

Pques,duchteuP,asa,Stche,

Senol,bncoJ,ontoyG.

Nucleic Acids Res. 2010,Sep16

Pnt:2011;39;729-743

21

COPTaTiONalbiOlOGY

d.GeogeSv,heofthecomputtonoogyeptmentWhenpojecteques

ffeentstenthegenometoemoe,CeectstemscetenewmegnucesefomtheOmegse,nkofmegnuceseswthmoechctestcs,popetyofCeects.


12/27


bSiNESSdEVElOPENT

in2010,Ceectsenteentocensegeementwthboehngeingehemtootn,eenutzenmmoesfophmceutcesechthoughoutEuope,sweswthbyeHethCetousetshomoogousecomnton

ptents.baSpntscenceshssooenetscoo-tonwthCeectstoutzetscustommegnuceses.

acqustonofssetsfomCytoPuseinc.Eectopotonsveyefcentwyof

nsetngmoecuessuchsmegnuceses

ntonytypeofcenhsppctons

ngngfomesechnomnufctung

togcutuenthepeutcs.

Thoughthstnscton,Ceectscque

theeothetechnoogesseoneec-

topotonneveopeyCytoPuse:

demvxfotnsemdNavccnton,

Oncovetfovetenyvccntonpp-

ctons,nHymmunetomnufctuehyomsfomonoconntoes

poucton.Thetnsctonwsnze

onSepteme2,2010,fo$2.2.

HvapptusgntecensegeementThsgeementgnteHvapptus

thewoweexcusveghttomnufctue

nmket,foesechuse,thefuneof

eectopoton-senstumentstht

CeectscquefomCytoPuse.

Ceectsetnsghtstousethesenstu-

mentsfotsownesechneveopment

pogmsswesncnctsnpo-phyctcothepeutcpoceues,footh

humnsnnms.nethegeement,

Ceectswecevepymentof$1.3

fomHvapptus.Ceectswso

contnuetoecevennucensngfees

fomsomeoftscustomes.

lcensetouseEvogenuoescentpotensThsnon-excusvegeementwthEvogen

(oscow,russ)hsoweCeects

oesechtoncopotethesepotens

ntotsownpouctsnthusexpnts

ngeofgenomeengneengtoos.

Thentegtonmtxsoneofthekeycom-

ponentsoftheCeectsoesechkts.it

sthsmtxthtowstheusetoexpess

geneofnteest.byextenngthechoceofpomotesntgsnthesemtces,

Ceectsoesechcnoffetscustomes

fungeofmethostochevesnge-

phseeveopments,thussvngvue

tmeungexpements.

ageementwthlonzfomoctonofoengneeeceneCeectsoesechwusetsmeg-

nucesestonctvte(knock-out)thegutmnesynthetse(GS)genenCHOK1SV,

lonzspopetyhostcene.lonzs

woeenthepeutcpotenspouc-

ton.itstytocontopouctonofthe

hghestqutycenesmkesthecompny

pefectptnefotheppctonof

Ceectstechnoogyntsmegnuceses.

Weeeghtetoewok-ngwthCeectsoesech.Thscootonmkessensenwenhnceouong-stnngnsuccessfuGStechnoogy.

Johnbch,CSOoflonzbophmceutcs

lcensegeementwthwestOseesfopnttnsfomtonThsgeementenesCeectspnt

scencestousewestOseesaeoso

beminjecto(abi)technoogyfothe

tgetemoctonofpntgenomes.

ThewestOseesabitechnoogy

enesfunctonmegnucesestoe

eveeectyntopntces,thusvo-

ngtheneefodNavectos.Thsppoch

wowCeectspntscencestomofy

pntgenomeswthoutntegtngdNan

thepnt.

ThemofthebusnessdeveopmenttemstocommeczeCeectsnteectupopetyntocqueothecompnesiPthtwousuppottheeveopmentofnewtechnoogesopoucts.Ceectsnnovtventeectupopetyhsongeofppctonssuchsheth,gcutueoesech

egngstemcesntentveeneges.Thebusnessdeveopmenttemssonchgeoftheusnesscontctswthouptnes.

Thebusnessdeveopmentsttegy

compsesvemnes,whchw

hepCeectsvncetseeshp

ngenomeengneeng.

Thesee:

Togvepotytomegnucesesfo

thepeutcppctonsnoetotet

egenetcsesesnvnfectons,

ntoeveopnewpouctstoghtcnce

otompoveogenectnspntton

(tnspntetweentwogenetcy

ffeentpesons).

Topo-ctveytnsfetstechnoogyto

mjocemcnnustotoes

foesechpuposes.

Toententousnessgeementsnts

foumnesofppcton:hethce,

otechnoogy,gcutuotechnoogy,

nstemces.

Tostengthenpvegeptneshps

estshewthsomeofthemjopyes

ngcutuotechnoogy.

antosustnCeectscompettve

vntgeycontnungtoenhncets ptentpotfoonyncesngts

technoogcenexpetsenoe

tongvuetothepotfoo.

ombusnessdeveopmentpespectve,

2010ntteshftnfocusfom

outcensngofnteectupopety

towsgenetngncomefompoucts

eveopeusngsuchnteectupopety.

Wheesthemnsouceofevenue

emnecensestohomoogousecom-

ntonptents,thencopotonn

expnsonofCeectspntscences,

theexpnsonofthestemcectvtes

nEctycethnkstotheShnyYmnkPScense,nthecqustonof

theCytoPuseeectopotontechnoogy

wfomtheconestonesofpoucts

seonCeectsgenomeengneeng

technooges.Thstenwcontnue

though2011wheeCeectsexpects

sgncntncomefomcensngof

tsnteectupopetypotfoo,utso

expectstosgnnncesngnume

ofptneshpstoeveopnnovtve

pouctsnmutpees.

d.dkPoet,ChefbusnessOfce

d.dkPoet,ChefbusnessOfce


13/27


ThemoftheCopotedeveopmenttemfo2010wstosetntoctontheoppotuntesvetousntheeofstemcesyestshngceptfomfopoputonengtotwoffeentppctons:esechtoosncethepy(tnspnts).

Themstoognzecoectonofces

thtepesentthephysoogy,pthoogy

nvestyofpoputonsothtwecn

unestnthsvesty in vitro.Thent

puposestoutzestemcestompove

unestnngofsesesnthemech-

nsms.ifwecncoectcesmpesfom

onoswhohvetheseseses,nhve

ccesstothemeces,twthene

possetostuythesesevthenuce

PupotentStem(PS)cesgenetefom

theptentsces.

TheCeptfompojectwstheefoe

setuppmytonustzePScesn

mkethemothoustnsfe.2010

eneustoensuethtoupojects

mtezeygvngthemthenecessy

esouces.TheCepojecteceve

funngcommtmentfomtheegon

uthotes,the Caisse des dpts et

consignations (bnkfoOfcdeposts)

nOSEO,pucentepsewhose

mstofunnsuppotnnovtonn

compnygowth.

inton,twonon-excusvecensegee-

mentshvegvenCeectswoweccess

tothenucePupotentStem(PS)ce

ptentpotfoosngfomthewokofPofessoShnyYmnkttheCentefo

PSCeresechnappcton(Cra)t

thenvestyofKyoto(Jpn).Ceectss

thestcompnynthewotoecense

yPSacemJpnunethsPSce

ptentpotfoofohumnthepeutcsn

pophyctcs.

Ceectshssoenteentocoo-

tonwthCratocomneCeectsgenome

engneengtechnoogeswthCrasPSce

technoogytompovethentuchcte-

stcsofPScesfousesceutoos.

Weesttng2011wththeessentkeysfosuccess.itsnowuptoustoensue

thtoupojectsechthefupotent.

d.dvSouve

egnucesesoffenewposstesfoestshngvetentvetoo.cogeectuythoughttoeveypomsngsouceoftentvetooevtve:fue,chemcmoecuesomtes.

Thssptyuetothestongtytopouceosnthegowthneffectveyete.

ocusonosusttuteOumegnucesetechnoogywoue

wesutetohepoptmzethesettsn

enennustztonofthepocesses.

asntusouce,geoneecuenty

thoughttoeetomeettheemn

fofueeffectveywthoutcompetngwth

nothenee,suchsfoosuppy.age

sousethepocessofphotosynthessn

theefoeneeght,wtenCO2,mkng

themnenvonmentyfenyfue.

itwsfotheseesonstht,n2010,

Ceectssetupesechtemtofocuson

mco-ge,ntomsnptcu,s

possesusttutefoo.dtomsey

pynmpotntoentheenvonment

ecusetheypouceone-fthofoxygen

pouceonetheveyye.dtoms

eunceugefounnmosthum

envonmentsnoffehugevesty,wth

100,000speceseyente.

apemnypogmwstheefoeset

uptCeectsnoetopovepoofof

pncpessoonsposse,ptcuy

egngthepotentofmegnucese

efcencynthesege.

COrPOraTEdEVElOPENT

d.dvSouve,EVPCopotedeveopment d.aetoamto,pojectee,genomeengneengonge

dffeentknsoftoms

iNTEllECTal PrOPErTY HaN rESOrCES CONiCaTiONS


14/27


S/Ca Euope as aust

2000

2001

2002

2003

2004

2005

2006

2007

2008

2009

2010

OneofCeectsfoemostssetsstsnteectupopetypotfoo.TheinsttutPsteuptentfmescovengtheuseofhomoogousecomntonnmegnucese-typeenonucesesfonucngdNaecomntonfometheptfomuponwhchCeectswsntyfoune.

Wehvesnceeveopestongpop-

etypotfoo,wthptentscossthee

octegoesgenepncpes,

megnucesesnthespeccpp-

ctons,nmnufctungpocessesof

moemegnuceses.Ousttegy

nvovesexpnngthenteectupopety

potfootofuthepotectoupoucts,

theppctons,nthecoesponng

oyoftechnoogcknowege.

attheenof2010,Ceectsownethe

ghtsto83ptentswowe,ncung35

nthenteSttesnCn.Thsmens

tht25newptentsweeotneovethe

couseoftheye.Ceectscuentyhs

moethn260ptentppctonspenng.

in2010,Ceectsoughtthessetsof

CytoPuseinc.,compnythtspeczes

neectopotonsystems,nthoughths

opetonotne16newptentsto

totsnteectupopetypotfoo.Thnks

tothesenewptents,Ceectsweceve

eguncome(>$600,000n2009),eve

fomthegntngofexpottoncenses

foCytoPusesHymuneTeectofuson

technoogy.

Thecompnystvestooptmzenupho

thenteectupopetytcensefomtheinsttutPsteu.Ceectssoenevosto

pomotetsnteectupopetyyefen-

ngtsownghts,wheespectngtheghts

ofothes.

Evolution of Cellectis IP portfolio

NumeofptentsgntetoCeects,peyengeogphce

100

80

60

40

20

0

iNTEllECTalPrOPErTY

Wthhecountththsgownfom5n2000to129ttheenof2010,thekeywonoucompnysclelyevelopment,ntemsofouemployeesnthetlents,swellsoucoetechnology.

ThepocytCeectsnvovesenngou

stfftoevovesthecompnyoesso.

reectveofthepssonnetemnton

toseeCeectsecomemjopyen

otechnoogy,someofthepevouspoject

eesenowttheheofeptment

nsomeotoytechncnshvetken

upengneengssstntfunctons.

oeove,Ceectspovessuppotfo

thosenvuswhowouketofuthe

theeuctonnengneeng.

Theseynmcshepusttctnewtent

toCeects,unfycuentstffnestsh

genunecompnyenttynthemst

ofcontnuousgowthneveopment.

Ceectsspouoftstemsptnntens

toexpntsenegytomntnt.

Temungssochevethough

semnsnotheegun-houseevents

thteognzeytheCommunctons

deptment.Theeptmentssoespon-

sefopomotngCeectstechnoogy

nexpetse.Oneofthemntoossetup

ytheCommunctonsdeptmentn

2010wsthenewcopotewestewth

sevekeyfetues:nfomtonshng,

ntectvtynectemee.

inghtoftsexpnson,Ceectschoseto

povevstostothewestewthcee

nmoeccessensghtntotswok,

pouctsnchevements.Vstostothe

newwesteeensueenhnceusty

nnfomtonshng,ncungmoe

stemneccesstonfomtonout

Ceectstechnoogesnpoucts.

ThenewCeectswestefocusesonthee

centthemes:

resechntechnoogy

busnesseveopment

investoetons

intontothesefocuses,theweste

offesnewfetuesnfeshcontentncung:

SevespeccrSSfees,sotht

suscescnmontotheCompnys

usnessnetme,choosngonythe

sujectsthtnteestthem.

infomtonshngvsocnetwoks

(ptcuyceooknTwtte).

downoeocumentsthtexpn

Ceectstechnoogy.

iusttveveosnegufetueson

vousspectsofCeectstechnoogy

tohepmpovethepucsunestnng

ofouscentcpogess.

HaNrESOrCESCONiCaTiONS

TheinteectuPopetyTem

SHarEHOldEr rElaTiONS


15/27


lettestoshehoesitsveympotntfoCeectstofoge

cosenkswthtsshehoesnths

swhythelettetoShehoespoject

wsntten2010.Thssqutey

etteessesoeytoshehoestht

summzesncommentsonthetest

news.itoffeswyfoCeectsCEOan

Chouktomntnectnegu

contctnthusustngntust-

seetonshpetweenCeectsntsshehoes.EchlettetoShehoes

sohs3Questonsntevewwthone

ofthekeypeopetCeectsontopcof

ptcueevncetothecompnytthe

tmeofssue.Theessoocusonone

ofouconstnty-evovngctvtes.

Event:str&ddyOnNoveme30,2010,Ceectshets

stresech&deveopmentdy,towhch

tnvtenvestos,nystsntheme.

Thsevent,ntenetoethestnsees,

wschncefoCeectstofogestonge

teswththenvestmentcommunty,getto

knowthesenvusette,nexchnge

es.Theguestsgnemoen-epth

unestnngoftheusnessctvtes

ofCeectsntssuseswthtouof

thepemses,nptcutheotoes,

ungwhchtheymetthetemsththve

meCeectsthecompnytstoyn

epesentthevuestuphos.

oowngtouoftspopetytechnoogy

fctythtcetes,poucesntests

megnuceses,memesoftheCeects

mngementnscentctemsete

thectvteswthntscoeusnesses:

megnuceseengneengtechnoogy,

esechtoos,genomeengneengnpnts,

nthepeutcpogms.

dSegebun,fomtheenchuscu

dystophyassocton(a),gven

upteonhsognztonscooton

wthCeectsnthepeutcs.Toconcue

theevent,thepotentppctonsofnucepupotentstemce(PS)techno-

oges,fowhchCeectsecentysgne

censegeementwthPSacemJpn,

weesoesce.

Thepesenttonsevet

www.ceects.com/nvestos.

TheCeectsCommunctonstemso

mngeseveythngthtetestothe

puctonofyeynhf-yeynnc

esuts,nognzesthegenessemes

whchecheyChstnPoc,Chmnoftheboofdectos,n

tteneytheCeectsshehoes.

athenfomtonoutthegene

ssemessventheinvestose

ontheCeectswestewww.ceects.com.

ypostonntheiTgoupscenttotheusnessnnvoveswokngcoseywththestfftCeects.imgicnhepthempogesstheesech.Snlpze,NetwoknSystemTechncn

ichosetowoktCeectsecusetswe-known,gowngotechnncethtseveopngnnovtve

technoogeswththeojectveofecomngtheeengenomeengneeng.

JuenPontn,Senoltechncn

Ceectssynmccompnynwhchtemsptnstongmotvtonethevngfocesthteusfutheeveyynpusungnnovtvenfscntngmttes.Chsteerochon,resechenCeunoecuboogytEctyce

Ceectsshuofnnovtonnwhchcommunctonmongtemsnetweeneptmentsowsctvey.Wokngwthtemsthtehghyskenopensveyewngpesonnpofessonexpeencefome.JustnEyquem,TneeEngneengpepnghsthesstCeectsthepeutcs

SHarEHOldErrElaTiONS

Cellectis staff

4%

25%

71%

Scentcdeptments(Sd)busnessdeveopmentamnstton

Ceects71%SdCeectsoesech71%SdCeectsthepeutcs*100%SdCeectspntscences100%SdEctyce100%Sd

*exgenomesugey

bekownyctegoes

Breakdown by subsidiariesTot:129(ncung4ntheSan2ntheK)

EctyceTem

lotoestou

CEllECTiSbiOrESEarCH


16/27


SbSidiariES

clebozec,ChefnncOfceofCeectsnChefExecutveOfceofCeectsoesech

2010Hghghts2010wsfoCeectsoesechyeofconsotonntemsofesechneveop-

ment,suchthtweenowetomketove150poucts.Weeptcuypese

wththsgowth,gventhtweonyuncheoustktndeceme2008foowngthe

cetonofCeectsoesechnJuneofthtye.Weeetosuppygenume

ofnewpoucts,usttngveyveseoffeng.in2010,wehvepteoupouctsto

vetyofcenes,evenceoftheefcencyywhchwengnewpouctstomket.

Wesooptenewmketngsttegytonceseouvstynpycometo

compettonwththemngopyesnesech.Thsnvoveothttonvetsng

nthepessnonthewe,swesttenncetsome20teshows,utsomoe

ognmketngmethos:nntectveweptfommetthescentccommunty

enggenusngnewgenomcs-etetechnques 1ncompettontopovenncng

fopost-octopostonnvovngpojectncunggenomecustomzton.om

usnesspespectve,theesutsweeveyencougngsncewemoethnoueou

opetngevenues.WesontegtethemketsheofCytoPuse,namecncompny

whosessetswecque.Thsncuecompetengeofeectopotonnstuments

eycommecze,swestheetenteectupopety.Ceectsoesechs2010

opetngevenuesmetthetgetsnexpecttonsset.inthecuenteconomccmte,

thsssomethngwecneveypouof.Ousuccesssuetooutentetem,

whchnowncues20empoyees,two-thsnr&dnone-thnsesnmketng.

Chengesfo2011dungthecomngye,wewfocusontheemnestocheveougoofpovng

oucustomeswththousnsofpoucts.Thestestechnoogy.Wheeswecuenty

suppymnytgetentegtontoos,oumstosuppyothtgetemoctonn

nctvtonsoutonsso.Theseconestoexpnoupouctnenothespeces,such

spntskeArabidopsis thaliana,wey-usepntmoe,oothekeynmmoes,

suchsnemtoe C. elegans.in2011thesekeymoesetounegoNHEJ(NonHomo-

ogousEnJonng)megnuceseoTalEN(Tnscptonactvto-lkeEffectoNucese)

testng,oncethsnewtechnoogysfuympementeonouptfom.ThetheoffocuswetoexpnoueofppctonstotheadET(asopton,dstuton,eto-

sm,ExcetonnToxcty)testtosuppycenefocnceesech,cosetotheptents

physoogcety.oegeney,wemtomntnougowthntocheveshot-tem

pottywheweepoyesesfocenEuopenthenteSttes.itwswth

thsnmnthttheamecnsusyCeectsoesechinc.wssetupnOctoe

2010.Oumfo2011stosetuptemsnthenteSttesnEuope,toputusonn

equfootngwthoucompettos.Thenexttwoyesweecsvestheywetemne

thetypeofpottywecnexpecttocheve.

clebozec,CEOofCeectsoesech

1www.genome-engneeng.com


17/27


Ceectsoesechsuppesesechesnthefescenceswthesyney-to-usetoosfocetngcesnognsmsththvetheesepefomnce.

Ceectsoesecheveopsnmketsgenomecustomztonpouctsthtcneuse

tocetestensogenccenes,wthchctestcsnpefomncesptetothee

mnmkets:ugeveopment,genefunctonstuesnpotenpoucton.

cGPSncGPSCustomktsThesektsenesynefcentwyofusngCeectsmegnucesetechnooges.

Wththekts,genecnentegtentonextemeypecsestenthegenome.

attheenof2010,Ceectsoesechwssuppyngove150pouctsvtsonne

shopnntentonstutonnetwok(innCn).ThecompnyCeects

oesechinc.wsecentysetupnCmge,sschusetts(nteSttes)to

pomotethecompnyspouctsnceneengneengsevcesthoughoutamec.

Thegenomecustomztonktscontnegentsnpotocosthtenepecsen

tgetemoctonofdNasequencesnthegenomeofnteest,ofwhethecene,

pmyce,stemceonenteognsm.

Tgetentegtonnvovescopynpstepocessthtspefomey

megnucese,nntegtonmtxnthehomoogousecomntonpocess.

Ceectsoesechstgetentegtonktseesyney-to-use,nncue

competepotoco.Echktcontnsthecomponentsthteneeefotgete

ntegton:w-typeoengneeemegnucese,nntegtonmtx,n,n

cGPSktscene.

Theesechktsnenowncuesvenewcetypes,nthepouctoffengncues

piStoe,coectonofoun100ntegtonmtcesthtcneusewthffeent

kts.in2010,Ceectsoesechunchetsstcustomzesevcetoeveste

conesycGPStgetentegton.2010soswmjor&dptneshpwthlonz,

woeenotechnoogymnufctungwththemofmofynglonzspopety

ceneCHOK1SVusetopouceotechnoogcugs.

astuyshowethtCeectsoesechstechnoogyseonmegnucese-ven

tgetentegtonsfste,moeeenmoeefcentthnttonmethosn

evngce-sessysfoHghThoughputSceenng(HTS)stues,whchowp

sceenngofvstnume

ofnewmoecues.egnucese-ventgetentegtonusngCeects

oesechscGPSCHO-K1ktstheefoehghyefcentfougeveopment.

Theesutsofthsscentcstuyfocusngonunquemethofogenetngstece

nescomptewthhghthoughputsceenngweepusheonneJuy12,2010ythe

JounofbomoecuSceenng.

Thechengestoepcettonceengneengmethosseonnommoctonwthtgetentegton.clebozec

Meganuclease-Driven Targeted Integrationin CHO-K1 Cells for the Fast Generation ofHTS-Compatible Cell-Based AssaysCnosJ,OuvyC,lmmyV,eyi,Cpet.l,ouhtN,GuennS.P,beutS,NosjenO,eyG,devvyS,JcqmcqC,leuhoteC,thsl,deenC,boutnJ.a,duchteuP,

Cog,nPquesJ. Biomol. Screen.Sept2010-vo15no8p.956-967

integtonofntuegnuceseecogntonste

Wtypeegnucese

Engneeeegnucese

dNarep dNarep

egnuceseengneeng

cGPS cGPS

CustomcGPS cGPS

Custom

CEllECTiSPlaNTSCiENCES


18/27


betweennowntheye2050,thewospoputonwgowfomppoxmtey6ontomoethn9onpeope.Thsncesenpoputonsze,coupewthchngngcmtenncesngymteesoucesfogcutue,wpceenomousstnsonoupnetscoectvetytopovethefoo,fuenenecessytosustnhumnkn.

Oneghtspotonthsothewsetouesomescenosthepomseofnewtechnooges.

Genomeengneeng,nptcu,wpovenewcoppntswthttsthtcnmeet

theemnspceongcutuenthecomngeces.

Cetench2010,Ceectspntscencesssusyectetoppyng

sequence-speccnucesesfopntstoeveopnewspeceswthttsofvue.The

compnysmngosetoncesencceeteuseofCeectspopetytechno-

ogyngcutuotechnoogy,tooenthecompnysexpetsetottctnewn

expnecensngoppotuntes,ntoexpoetheeveopmentofpopetytts.

Ceectspntscencessecteywo-cssscentctem.Thecompnysscentsts

weethesttompementgenomeengneengnpnts.amongthetemmemess

thesusyChefScentcOfce,dneVoyts,whosntentonyenownefo

hswokonpntgenomeengneeng.d.Voytsssopofessotthenvestyof

nnesotwheehehestheCentefoGenomeEngneeng.d.engZhngseves

sthesusydectoofresech,nhehsextensveexpeencenmze,cen

Arabidopsisgenomemocton.inton,thecompnysstffeytwoPhd-eve

scentstsntwoesechssoctes.

intsstyeofopeton,Ceectspntscencesemonstteefcentmocton

ofpntgenesyengneeemegnuceses.lucths,Pogmsnbusnessdeve-

opmentdecto,hghghtethtwthnmonthsoftsncepton,Ceectspntscences

otnepoof-of-conceptt.Theseesutsemonsttethtmegnuceseshvesm

cpctesnpntcesspevousyshownnhumnces.omthsstongt,Ceects

pntscencessnowfocusngontscommecms:toevepoucts,sevcesn

censesfothegcutuenustyswestoupotfooofgcututtsnts

eofexpetsetgetemutgenessnseectepntspeces.

Thssveyexctngtmenpntoogy,nouecentvncesngenomeengneengmknewe.itsstmutngtoenvovencompnythtcnhvesuchectmpctonhumnvesnthewe-engofthepnet.P.dneVoyts

Thene-temgoofCeectspntscencesstomovewyfommoepnts(Arabi-

dopsisntocco)ntoppytstechnoogytocommecpntspeces.TheCeects

pntscencestemeyhsexpetsentnsfomngcon,censoyen,nthese

sksweessentnepoyngthenextphseofthecompny.

ithstoetkenntoccountthttheegutoypocessequetoeesegenetcy

moepntsntotheenvonmentsveyexpensve.asCeectspntscencesscentc

temmpementstsgenomeengneengstteges,theyensuethtonymnm

chngesemetothepntsgenome.itshopethtpntgenomesmoewth

thsknofpecsonweettecceptenthemketpce.

PofessoVoytshseenwthCeectspntscencessChefScentcOfcesnce

thecompnywssetup.HespofessonthedeptmentofGenetcs,Ceboogy

ndeveopment,ndectooftheCentefoGenomeEngneengtthenvesty

ofnnesotnnnepos.Speczngnmoecuoogyngenetcs,P.Voyts

esechfocusesonpntgenomemoctonusngnucesesthtcnecognze

speccdNasequences.

HesneecteeowoftheamecnassoctonfotheavncementofScence.

HesnassocteEtofothejoun GeneticsnEto-n-Cheffothejoun

Mobile DNA.Hestheco-founeoftheZncngeConsotum,goupofscentsts

ectetopomotngppctonsofzncngepotensfogenomemocton.

Hehsuthoeoco-uthoeozensofscentcppesntheeofgenome

engneengnpntspeces.

P.dneVoyts,ChefScentcOfceofCeectspntscences

ECTYCEll


19/27


EctycewsestshenSepteme2009toppytheenetsofCeectscoetechnoogestoeveopmentswthntheeofstemces,especynucepupotentstem(PS)ces.

Thssusywutzethesetechnoogestotnsfomstemcesntotueeveop-

mentnmnufctungtoosthtwenove,oust,epoucenusenhgh

thoughputexpements.

Ectycehsnumeofesechnttvesunewythttkevntgeoftheenets

ofmegnucesesfogenomcengneeng.Thesepogmsncue:

deveopmentofCenPSCesygenetngPScesfomutcesusngtgete

ntegtonnexcsonofepogmmngfctos,whchwccumventthenecesstyto

usenomvntegtonmethosfoPScepoucton.

deveopmentofnovenepoucemethosfoceuffeenttonfomPSces

usngtgetegenomeengneengtechnooges.

deveopmentofoustmethooogesnpocessesfogescepouctonofPS

nffeentteces

CetonofPSseceesthtweeysutetohghthoughputug

sceenngppctons.

inOctoe,Ceectsn-censenucePupotentStemCeTechnoogyfomPSacem

Jpn.Thetwoseptenon-excusvegeementsgntCeectswoweccess

tothenucePupotentStem(PS)cesptentpotfoosngfomthewokof

PofessoShnyYmnkttheCentefoPSCeresechnappcton(Cra)ofthenvestyofKyoto,Jpn.

PofessoYmnknhscoeguesponeeethsgounekngwoknCeects

sthestcompnywowetoecenseyPSacemJpnunethsPSce

ptentpotfoofohumnthepeutcsnpophyctcs.

Ectycewsfouneonthefctthteveopngey-stgehghthoughputsceenng

ssysthtettepectmoecueseffectontheognsmswhoeoongenet-

cyvesepoputoncousgncntyeucethehghtttontecuentyoseve

ungugeveopment.avncesuneeveopmenttEctycemysoopennew

oppotuntesnthepeutcs,ncungegenetvemecne.

WhtsnnucePupotentStemce?annucepupotentStemce(oPSce)snutceththseenepogmme

toehvekenemyoncStemce(oESce).

Whennovumsfetze,theeggves,nwthnshotspceoftmecese

fomeththvethepotenttoeveopntothetssuesoftheoy.Theseceseceemyoncstemcesneknownspupotentces.Pupotencysthety

togeneteffeentcetypes.

astheymtue,EScesguyosetheffeenttonpotentneveop

functonspeczton.oexmpe,ymphocytewtckenfectons,whees

pncetccewecpeofpoucngnsunfotheestoftsfe.

ntecenty,twseevetoempossefocetoetuntostteofmmtuty

necovetsffeenttonpotent.in2006,thetemofPofessoShnyYmnk

tKyotonvestyemonsttethttspossetoepogmmtueutcetogve

tckthepopetesofnemyoncstemce.inoefothsutcetoetunto

stteofmmtutyneetoffeenttentocetypes,youjustneettoexpess

fougenes(notnomyexpessenutces).Thesecesetemenucepupo-

tentstemces,oPSces.

EctycesesponsefospengCeectsgenomeengneengtechnoogesontothestemceenoetotnsfomthesecesntotuemnufctungtoosthteoust,epoucen

usenhghthoughputexpements.dvSouve,CEOofEctyce

How to make an iPS

4genes

pecseyequecetypeske...

...Neveces ...booces ...Ccces

Pupotentstemces

autce

CEllECTiSTHEraPETiCS


20/27


Ceectsthepeutcs,unchen2008unethenmeCeectsgenomesugey,focusesontheeveopmentofnnovtvethepeutcppochesthtusemegnucesestotetgenetcseses(suchsmuscuystophesnhemophs),cncesnpesstentvnfectons(hepesketts,aidS).

Thssusyhstemof19,ncung10Phds,nenevostonnnovtve

tetmentstotetptentswthseouscontonsthteesstnttoconventon

thepy.Ceectsthepeutcsmstofuunmetmecnees.Thetetment

pgmnvovestgetngthedNasequencethtcusesthesese,whchmyennte(genetcsese)ocque(vnfecton,cnces).

Thegenomesugeyppochmstoghtthecuseofptcusesencue

theptent,thethnmeeytetsymptoms.Sncetsncepton,Ceectsthepeutcs

hswoketogethewthtsptnescemcesechgoupsncncnsove

thewo(ncungChenHosptboston,insttuteVson,GenomcVson,CNrS,

iNSEr,nmnyothes)totnsfomtsesechntoeffectvemectetments.

CuentcnctsafteCeectsuyoutofthessetsofCytoPusenSepteme2010,thecompnyece

topusuetheptneshppogmththeensetupyCytoPusefotheuseofeecto-

potosfovccnton.CytoPuseseectopotontechnoogysptcuyeffectvefo

ntegtngmoecuessuchsmegnucesesntonyknofce.

Ceectssuppesthedemvxntemeectopotonequpmenttootoes

cyngoutcnctsequngthsknofequpment.demvxssystemtht

ppesneectcetofcttethentegtonofsmfgmentsofdNantoces,

theeypotentzngtheeffectofdNavccnesystmutngthemmuneesponse.

athoughdemvxwsognyeveopefocncevccnetetments,tsso

engtestetoyspophyctcppochonHiVnfectons.Theecnctse

engconuctettheKonskinsttutenttheCnceCentenStockhom,

ntheotoesheeyPofessosbttWhennEcSnstm,swest

ppsnvestyyPofessoTottemnndoctoYchnn.

2010wsyeofntensveenngfooththeCeectsthepeutcstemsntheptnesnognztonsnthemecotechnoogyewthwhomwecoote.aongsethestpoofsof

concept,weoftenponeeetechnoogyuse,pouctonnvton.Syvnanou,Phd,pecncpojecteetCeectsthepeutcs

2010wstunngpontfoCeectsthepeutcs,whchotneveypomsngesuts,ptcuyntemsofpoofofconceptonthentvctvtyofmegnuceses*.dungtheye,wesomesgncntpogessnoucethepypogms.

inee,outemhseenetoentfygootgetsfotheso-ceSfeHo

ppoch.Thsppochconsstsnenngstengenomethtowsthensetonof

newgene,whchmghteexpessewthoutntefengwththecefunctons.

Wesompementeneffectvenon-vvectoztonppochusngtheeecto-

potonsystemotnefomthetkeoveofCytoPusesssets.inton,we

otneveygoopemnyesutsnhomoogousecomntonnpmyces,

whchpepethegounfooucethepyeveopment.

ingenethepy,theesutsotneyouCnnptnesonduchennemuscu

ystophy*offesgooexmpeoftheenegyputnouthepeutcesechon

megnucesesyoucemcptnes.

inconcuson,ouwokn2010eneustootnpoofsofconceptnconm

ouscentcnegutoysttegy.Westt2011wththemofotnngpoofsof

pncpefotheseesutsonkeypthoogessuchshemoph*.

d.Coedesseux

*moenfomtonnextpge

egnucesescnesovethessueofnomntegton.ThepecsonoftheCeectstechnoogymensthtthenewgenecneeveetpeetemnensfeocton.Wehvehghhopesthtoneythsesechwetoeffectvenfe-enhncngthepesfohemoph

ptents.d.TheyVnendesschend.neeChuh,VibVesusresechCentettheCthocnvestyofleuven(begum)

d.Coedesseux,dectoofopetonst

Ceectsthepeutcs


21/27


iNaNCialSTaTEENTS

HepesvusScentstsfomCeectsthepeutcs,theenchNtonCentefoecresech

(CNrS),ninsttuteVson(Ps)hveuseCeectspopetymegnucesesto

successfuypeventnfectonofcutuecesyhepesvus(HSV-1).Theesechws

pushenthejounMolecular Therapy.Theseethestpoofofconcepttsto

showthtmegnucesescnpeventvnfecton.Thetceesceshowscentsts

usespeccmegnucesesengneeeyCeectstopeventthenfectonofhumn

cutuecesyHSV-1.

SusequentnyssofthetetecesysequencngshowethtthevdNah

successfuyeencppeythemegnucese,ntheefoeosttscpctytoepcte

nspe.

duchennemuscuystophyresechestthelvnvestyHosptCentenQueec(Cn)usemeg-

nucesesengneeeyCeectstoestoetheexpessonofmcoystophnnhumn

myostsin vitronnhumnces in vivo.Theyweetheefoeetoshowthe

potentofusngmegnucesestotetduchennemuscuystophy.Thesenew

nngsweepushenthescentcjounGene Therapy.

GenethepyfotetnghemophThefescencesesechnsttuteVibnCeectsecootngonesechntonew

ppochestotethemoph.Theyeusngmegnucesestoepcefutyoo

cottngfctogeneswthfunctoncopes.Hemophsgoupofheety,ecessve,

X-nkegenetcsoesthtmptheoystytocontooocottngo

coguton.Hemophptentssuffetovousegeesfomuncontoenteno

exteneengfoovessesoken.inessuchsthenonsejonts,

thseengcneftopemnentyettng.

Publications

HepesvusMeganuclease-mediated Inhibition ofHSV1 Infection in Cultured CellsGosseS,HuotN,hetC,anouS,beuS,Ceedl,Chon-Sotnei,JcqmcqC,Chpeeb,Egna,desseuxC,Cone,ConseeE,Pques,letoue,SmthJ.Molecular Therapy.2011Jn11.

duchennemuscuystophyMeganucleases can restore the readingframe of a mutated dystrophinChpeneP,PchvntC,rousseuJ,PquesnTemyJ.PGene Therapy (2010)17,846858;

iNaNCialSTaTEENTS


22/27


assets Equtynltes

g u es n t ho us n s o f eu o s d ec em e 3 1 201 0 de ce m e 3 1 20 09

Net intangible assets 3976 903

Net tangible assets 3913 2893

Non-current nancial assets 231 231

Deferred tax assets 8169 5133

Total non-current assets 16289 9160

inventoes 153 118

Teeceves 2491 1768

resechtxcetnsuses 6588 1570

Othecuentssets 2486 2465

Cshncshequvents 24048 45080

Total current assets 35766 51001

TOTAL ASSETS 52055 60161

g u es n t ho us n s o f eu o s de ce m e 3 1 20 10 d ec em e 3 1 200 9

Share capital 584 582

Shepemumneseves 45170 52404

Netncome/oss (8063) (7768)

Equity 37691 45218

retementenetogton 120 42

boowngs 809 491

Othennctes 588 795

Povsons 50 71

Total non current liabilities 1567 1399

boowngs 560 748

Othennctes 257 107

Teccountspye 8464 6548

defeencome 3516 6141

Total current liabilities 12797 13544

TOTAL EQUITY AND LIABILITIES 52055 60161

intngessetstdeceme31,2010ncue 2.4ofeveopmentexpensesn

1.5monfoptentscense.resechneveopmentexpensesconcenngktsn

pntctvtesencueunessetsfothesttmen2010,whchffesfom

scye2009.Thssesutofthegowthofothctvteswhchnowgeneteecu-

entevenues.Thetotofptentssetssgncntyncesesesutofthecqustonof

CytoPuse,inc.ssets.

Note:

Snce2010,thecompnyhsenevoetompovethequtyoftsnncepotngypushngcompeteccountsnnewthirSstns.

Thspocesssnongongone,equngfutheesttements,ptcuythoseconcenngevenueecognton,esngcontcts,efeetxssetsnthecptztonofcetneveopmentexpenses.TheguespesenteheetheefoencuetheesttementsequeyirSstns,uttthetmeofpushngthsepot,theconsoteccountsweestengeveweythesttutoyutos.

Tngessetsmnyconssteofotoyequpment.

ThetxcetssoctewthossescefowyCeectsntssusesws

cptze,gventhepospectsfoecovety.

The(cuentnnon-cuent)boowngstemmnycoesponetotheesttementof

esngcontctsfootoyequpment.

Theothennctesconssteofefunevncesgntetothegoupfo

vousesechpogms.insummy,thecompnynncetsneggewheequty

cpteche38ttheenof2010.


23/27


CshowSttementPot&loss

guesnthousnsofeuos

2010

12months

2009

12months

Net income/loss of the year (8063) (7768)

depecton&motzton 1186 793

Cptgnonssetsspos (61)

defeeTxes (3036) (1749)

Shesepyments 435 1045

Othenoncshtems 144 (30)

Cash Flow f rom operat ing activit ies before Working Capital change (9334) (7770)

( in ce se) / dec e se n c cou nt s ec e v e ( 75 8) ( 89 3)

(incese)/deceseofresechTxCet&Suses (5018) 1321

( dec e se ) /in ce se of t e c co un ts p y e 1 9 16 71

Net c hn ge no th e s set s n t es ( 26 72) 39 52

Change in working capital (6532) (4451)

NET CASH PR OVI DED (USED) BY OPER ATIN G ACTI VI TI ES (15866) (3319)

acqustonofntngessets (3528) (1017)

acqustonoftngessets (1477) (448)

acqustonofnncssets

Netncomefomseoftngessets 729 719

NET CASH PROVIDED (USED) BY INVESTING ACTIVITIES (4276) (746)

Newoowngs 0 0

repymentofong-temoowngs (983) (1079)

Poceesfomssunceofcommonstock 9 3 2 229 6

NET CASH PROVIDED (USED) BY FINANCING ACTIVITIES (890) 21217

CHANGE IN CASH AND CASH EQUIVALENTS (21032) 17152

Openngcshncshequvents 45080 27928

Cosngcshncshequvents 24048 45080

INCRE AS E (DECRE AS E) IN CAS H AND CASH EQUIVAL ENTS (21032) 17152

guesnthousnsofeuos

2010

12months

2009

12months

Ses 8166 7613

Otheevenues(resechtxcet&suses)1 7609 2527

Total operating revenues 15 775 10 140

CostofSes(censng-n) (1445) (1449)

Gross Margin Prot 14 330 8 691

resechndeveopment (12311) (7971)

ketngnamnstton (13457) (10601)

Othencome 0 78

Otheexpenses (27)

Current operating income/loss (11 465) (9 803)

nncncome 485 463

nncexpenses (153) (173)

Othenncncome&expenses 34 (4)

Net operating income/loss 366 286

incometx 3036 1749

NET INCOME (8 063) (7 768)

1incungesechtxcet 6148 1255

Thencesenther&dtxcetn2010esultenconseblencesenthsecevble

tdecembe31.intngblenvestmentsn2010conssteof 1.9cptlzeevelopment

expenses,longwthptentcqustons.appoxmtelyonethoftheyescshbun

wsffectebytempoyunfvoblevtonnwokngcptlequements.in2011,

thechngencsh(ncshequvlents)sexpectetobenethelevelofnetncome.

revenuesfomcensesnesechktsesnceseymoethn7%n2010.Ths

ncesessgncntconsengcetngeementswthmjogoupsththveeenpce

onhoonthemstofeognzton,ptcuyungtheunchpeoofnew

esechkts.Thenextscyesexpectetoshowfuthepogess,ptcuynktses

netesevces.

Ther&dtxcetncesesgncntyn2010( 6.1compewth1.3n2009),

mnyuetothencesenr&dexpentue(+54%)ntheeuctonngntseceve

n2010.ackgounstuywsconucteyCeectswththehepofconsutntsnoe

toestmtether&dtxcet.

Thencesenopetngexpensesn2010suetothempementtonofmjogowth

sttegyoutnen2009,theconsotonofupstemesechtemsfoCeects,n

ppctonptfomeveopmentfoechofthesuses.resechneveopment

expensesnceseyppoxmtey50%,whchemnsconsstentwththestffncese

(+50%fomtheenof2009totheenof2010).


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ShePcenCptStuctue

aPPENdiCES

3

4

5

1

6

21.eeot62%

2.CopotePtnes4%

3.ounes&ngement15%

4.busnessange10%

5.VentueCpts5%

6.insttutPsteu4%

Shareholders Breakdown as of December 31, 2010

Ceectsshepceswowntunungthe2010nncye.infct,thest

tngyof2010nshetpceof10.95peshenthesty(deceme

31st)nshetpceof7.40peshe,thusshowngnetfof32.4%.Seve

fctosexpnthsowntun:thecontnueextofventuecptstsshstoc

shehoes,owytevoumesnmketvottynketosgncntmco-

economcuncetnty.

Thecptstuctuehscontnuetoevoveytheextofventuecptshehoes

nchngesesutngfomthecptncesettheenof2009.Thefeeot

hsnowechemoethn60%utthehcoehong,centeeounthetwofounes,theinsttutPsteu,theusnessngepesentnthecptsnce2000

nthenustcompnesthtenteen2008(regeneon)n2009(onsnto),

emnsunchnge.

Share Price Evolution

ShePcen SheVoumenthousnsofshes

100monmketcptzton.aout10,000she

vegevoume.

NYSE-EuonextaClS.Pa

2010

2009 ap Ju Oct

12

11

10

9

8

7

6

40

20

0

60

80

100

GOVErNaNCE


25/27


ExecutveCommtee,fomefttoght:dvSouve,anChouk,cPques,

dkPoet,Syvedessus,clebozec

ExecutveCommttee TheExecutveCommtteescomposeoftheseno-evemngementofCeects,whch

estshesconsoteojectves,montosthesttegcpojectsnecesonpotes.

itsmemesmpementthecompnyssttegynecttsy-to-yopetons.The

CommtteencuesanChoukndvSouve,thecompnysco-founes.

anChouk,Phd, Chie Executive Ofcer

anChouk,Phd,founeofCeectsSa,hssevesChefExecutveOfcesnce

thecompnysncepton.d.Chouksponeenthenyssnuseofmegnuceses

tomofycompexgenomes.Hehsmemnyofthectcosevtonsnthee

nsnuthoofthemostsgncntptentsontheuseofmegnucesesnvvo. d.ChoukecevePhdnoecuVoogyfomnvestyofPsVi/insttut

Psteu.d.Choukhsmepost-octostuesttheHvecSchoowthn

theeptmentofoecuecneofbostonsChensHospt.

dvSouve,Phd,Executive Vice President, Corporate Development

dvSouve,Phd,co-founeCeectsSawthdChouk,nhsseves

dectosnce2000.Potonceptonofthecompny,dSouvewstheheof

botechnoogylotoyttheCenteEtuesubouchet(enchnstyofdefense).

atthesmetme,dSouvewshengesechgoupnimmunoogytthePsteu

insttute.d.SouvetteneEcoePoytechnquenecevePhdnoecu

VoogyfomnvestyofPsVii/insttutPsteu.dSouvethenppe

ecomntontckngtechnoogestont-vmmunememoy,ttheEmoynvesty

VccneCentenatnt.

cPques,Phd, Chie Scientifc Ofcer

clebozec,Chie Financial Ofcer

dkPoet,Phd,Chie Business Ofcer

Syvedessus,Phd,Senior Vice President, Corporate Communication

boofdectosTheboofdectosetemnesthe

compnysttegynoveseesCeects

ctvtes.emesoftheboof

dectossevefotemoftheeyes;

theChmnconvenesmeetngs

whentseemenecessyoese.

Ondeceme31,2010:

ChstnPoc,Phd

Chairman, co-ounder o BiotechDeveloppement Conseils

tnbtsch,d

Independent director, Consultant

anChouk,Phd

Director, Chie Executive Ofcer, Cellectis

anGo

Independent director, Former Head o

Aventis Cropscience board o directors,

Consultant

rogeJ.Hjj,d

Director, Kaminvest Holding Representative

rchC.ugn,Phd

Independent director, Mallinckrodt Proes-

sor o Genetics at Harvard Medical School

and Director o the Harvard Gene Therapy

Initiative

dvSouve,Phd

Director, Executive Vice President,

Corporate Development, Cellectis

Psceate

Observer, Institut Pasteur Representative

ScentcavsoyboTheScentcavsoybo,setupn

2002,scomposeofeghtctvememes,

ppontefooneyenmeetstwce

ye.itsmssonstooutneCeectso

scentcoenttons.itpesentsCeects

mngementtemwthmethosn

sttegestochevethecompnystechno-

ogcgos.itevutesthewokcheve

ungtheyentheesutsotne.

Ondeceme31,2010:

Pof.nosJco,HonoyChmn,Phd

Collge de France, Paris, France

Pof.roneyJ.rothsten,Phd,Chmn

Columbia University, New York, USA

Pof.eeckW.at,Phd

Howard Hughes Medical Institute,

Chevy Chase, USA; Harvard

Medical School, Boston, USA

Pof.bendujon,Phd

Universit Pierre et Marie Curie (Paris VI) -

Institut Pasteur, Paris, France

Pof.ansche,d,Phd

Hpital Necker - Enants Malades, Paris,

France

Pof.JmesE.He,Phd

Brandeis University, Waltham, USA

Pof.densPompon,Phd

CenteofoecuGenetcs,

Gf-su-Yvette,nce

Pof.Jos-anShe,d,Phd

Hpital des Quinze-Vingts, Paris, France

Pof.lusSeno,Phd

Center for Genomic Regulation,

Barcelona, Spain


26/27

Ceects

Contct:Ceects102venueGstonrousse93230romnvenceTe:+33(0)[email protected]

Photos:rmontneznckbeonceCeectsTmrummehoff

EceeiNraChstopheteCcPochezStockphoto

Gphcdesgn:VentnHemnn

Pntng:GphCente

PnteonSCceteecyceppeusngvegetesenks.

dscmeThspuctonnthenfomtoncontneheenonotconsttutenoffetoseosusce,osocttonofnoffetouyosusce,foshesnCeectsnnycounty.Thspuctoncontnsfow-ookngsttementsthtetetotheCompnysojectvesseonthecuentexpecttonsnssumptonsoftheCompnysmngementonynnvoveunfoeseeesknuncetntesthtcoucusetheCompnytoftochevetheojectvesexpesseythefow-ookngsttementsove.


27/27

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