Download - Supplementary figure 3

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Page 1: Supplementary figure 3

raSIRP

RIKQKKAKGSTSSTRLHEPEKNAREITQIQDTNDINDITYADLNLPKEKKPAPRVPEPNNHTEYASIETGKLPRPEDTLTYADLDMVHLNR--AQPTPKPEPSFSEYASVQVQRK 509

muSIRP

RIKQKKAKGSTSSTRLHEPEKNAREITQIQDTNDINDITYADLNLPKEKKPAPRAPEPNNHTEYASIETGKVPRPEDTLTYADLDMVHLNR--AQPAPKPEPSFSEYASVQVQRK 509

huSIRP

1 RIRQKKAQGSTSSTRLHEPEKNAREIT--QDT---NDITYADLNLPKGKKPAPQAAEPNNHTEYASIQTSPQPASEDTLTYADLDMVHLNRTPKQPAPKPEPSFSEYASVQVPRK 503

**:****:******************* *** ************ *****:..***********:*. * .**************** **:*************** **

Supplem

entary figure 3

Supplem

entary Figure 3.

Alignm

ent of the cytoplasmic S

IRP

protein sequences. Alignm

ents were perform

ed using the ClustalW

algorithm (version 1.82)

employing the follow

ing sequences: rat SH

PS

-1 (gi_6671640), mouse S

HP

S-1 (gi_1777354), and hum

an SIR

P

1 (gi_2052056). The

two proline-rich regions are overlined and the tyrosine and proline residues are highlighted in blue and red, respectively. T

he proline residues that, at least in case of the hum

an SIR

P

1, are dispensable for JAK

2 binding (42) are indicated by arrows.