Supplementary figure 1

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Supplementary figure 1 a b e i h-VU-DIPG-3 m-VU-DIPG-3 h-VU-DIPG-5 m-VU-DIPG-5 c d f g h j k l * *

description

Supplementary figure 1. a. b. c. d. h-VU- DIPG-3. h-VU- DIPG -5. j. e. i. f. m-VU- DIPG-3. m-VU- DIPG -5. g. h. k. l. *. *. Supplementary figure 2. a. c. e. m-VU- DIPG -3. m-CNMC-D1. h-SU- DIPG -VI. b. d. m-VU- DIPG-5. m-CNMC-D1. Supplementary figure 3. a. b. - PowerPoint PPT Presentation

Transcript of Supplementary figure 1

Page 1: Supplementary figure 1

Supplementary figure 1

a b

e i

h-V

U-D

IPG

-3m

-VU

-DIP

G-3

h-V

U-D

IPG

-5m

-VU

-DIP

G-5

c d

f

g h

j

k l

**

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Supplementary figure 2

a c

b

e

d

m-VU-DIPG-3 h-SU-DIPG-VI

m-VU-DIPG-5 m-CNMC-D1

m-CNMC-D1

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Supplementary figure 3

a bHuman platform Murine platform

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Supplementary table 1

Patient h-SU-DIPG-I h-SU-DIPG-III h-SU-DIPG-V h-SU-DIPG-VII h-SU-DIPG-VIII

Age (years) 5 14 12 10 10

Sex M M F M M

Histological diagnosisat autopsy

Anaplatic astrocytoma(WHO grade III) GBM GBM GBM Astrocytoma

(WHO grade III)

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Supplementary table 2

Gene Forward Reverse

Human

H3F3A GGGCAGGAGCCTCTCTTAAT ACCAAGTAGGCCTCACAAGC

Hist1H3b AAGCAGAGGCTGACCAATCC TCCTTGGGCATGATGGTGAC

PI3KCA H1047R/L GCTCCAAACTGACCAAACTGT AATCGGTCTTTGCCTGCTGA

PI3KCA E542K CATCTGTGAATCCAGAGGGGA ACATGCTGAGATCAGCCAAA

Murine

H3f3a GTGTCCTTACCATGGCTCGT CAGCAGTTAAGAGCACTAGTTGA

Hist1h3b AAGCAGAGGCTGACCAATCC TCCTTGGGCATGATGGTGAC

Pi3ka H1047R/L ACTAGCAGCTCACTGACCAGA GCTATCAAACCCTGCTTGCG

Pi3ka E542K TCTTCCCCTTCGCCAAGTCTA ACAGGAAGAAGGTCCCTCGG

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Supplementary table 3

AMEL CSF1PO1 D13S317 D16S539 D21S11 D5S818 D7S820 TH01 TPOX vWa

h-SU-DIPG-VI Cortex Control X/X 10/11 11/ 8/13 29/31 10/12 8/9 7/8 8/11 17/18


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