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[footnoteRef:1] [1: Cerebellar Ataxia With Extreme Photophobia Associated With Anti-SOX1 Antibodies. Alessandro L, Schachter D, Farez MF, Varela F. Neurohospitalist. 2019 Jul;9(3):165-168. doi: 10.1177/1941874418802130. Epub 2018 Sep 24.PMID: 31244974 ]
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[footnoteRef:7]TBI[footnoteRef:8][footnoteRef:9]mildTBI [7: ( ), , 1 Page119-123(2007.10)] [8: Photophobia in neurologic disorders. Wu Y, Hallett M. Transl Neurodegener. 2017 Sep 20;6:26. doi: 10.1186/s40035-017-0095-3. eCollection 2017.PMID: 28932391] [9: Observer-perceived light aversion behaviour in photophobic subjects with traumatic brain injury. Yuhas PT, Shorter PD, McDaniel CE, Earley MJ, Hartwick AT. Clin Exp Optom. 2019 Nov;102(6):621-626. doi: 10.1111/cxo.12896. Epub 2019 Apr 29.PMID: 31037766]
Goodrich[footnoteRef:10])100TBIPTSDPTSDTBI383182PTSDTBI13/48,27% [10: Visual function, traumatic brain injury, and posttraumatic stress disorder. Goodrich GL, Martinsen GL, Flyg HM, Kirby J, Garvert DW, Tyler CW. J Rehabil Res Dev. 2014;51(4):547-58. doi: 10.1682/JRRD.2013.02.0049.PMID: 25144168]
155
ADHD[footnoteRef:13]231ADHDADHDADHD 2631 [13: High prevalence of self-reported photophobia in adult ADHD. Kooij JJ, Bijlenga D. Front Neurol. 2014 Dec 10;5:256. doi: 10.3389/fneur.2014.00256. eCollection 2014.PMID: 25540636]
ADHD69ADHD280.001ADHDADHD 0.05773%ADHD12.3ADHD1.20.0012.31.20.0013.10.0011.40.70.0010.001
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[footnoteRef:14]Judd[footnoteRef:15]316:772296229794+ 104+82 62123+636298+766277+564382+5244 [14: Diagnosis, pathophysiology, and treatment of photophobia. Katz BJ, Digre KB. Surv Ophthalmol. 2016 Jul-Aug;61(4):466-77. doi: 10.1016/j.survophthal.2016.02.001. Epub 2016 Feb 12.] [15: Shedding Light on Blepharospasm: A Patient–Researcher Partnership Approach to Assessment of Photophobia and Impact on Activities of Daily Living Rebecca A. Judd , MD,Kathleen B. Digre , MD,Judith EA Warner , MD,Susan F. Schulman , CCRA &Bradley J. Katz , MD, PhD Neuro-Ophthalmology 31(3):49-54 · July 2009.doi.org/10.1080/01658100701247646 ]
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111630481266[footnoteRef:16]1 [16: Blepharospasm in Japan: A Clinical Observational Study From a Large Referral Hospital in Tokyo. Wakakura M, Yamagami A, Iwasa M. Neuroophthalmology. 2018 Jan 9;42(5):275-283. doi: 10.1080/01658107.2017.1409770. eCollection 2018 Oct.PMID: 30258472]
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--18FDG-CT[footnoteRef:17] [17: Photophobia in essential blepharospasm--a positron emission tomographic study. Emoto H, Suzuki Y, Wakakura M, Horie C, Kiyosawa M, Mochizuki M, Kawasaki K, Oda K, Ishiwata K, Ishii K. Mov Disord. 2010 Mar 15;25(4):433-9. doi: 10.1002/mds.22916.PMID: 20014062]
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1 Katz [footnoteRef:19] [19: Major review Diagnosis, pathophysiology, and treatment of photophobia. Bradley J. Katz, MD, PhDa,b, *, Kathleen B. Digre, MDa,b. Survey of Ophthalmology 61:466-477,2016]



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Functional Vision ScoreFVS)[footnoteRef:20][footnoteRef:21][footnoteRef:22][footnoteRef:23][footnoteRef:24][footnoteRef:25][footnoteRef:26][footnoteRef:27]15FVSAugust Colenbrander [20: Colenbrander A :The Visual system. in Rondinelli RD (ed): Guides to the Evaluation of Permanent Impairment, 6th ed. American Medical Association (AMA) Publications, Chicago,281- 319, 2008(5th ed: Cochiarelli L, Anderson G, eds.277-304,2001)] [21: Colenbrander A: the functional vision score :A coordinated scoring system for visual impairments, disabilities, and handicaps. In Kooiman AC, Looijestijn PL, et al (Eds) Low Vision: Research and New Developments in Rehabilitation Studies in Health Technology and Informatics. IOS Press, Amsterdam, 552-561, 1994] [22: 1 American Medical Association AMA. 82:2 165-167, 2011 FVS 27] [23: 2 Quality of Life(QOL) Functional Vision ScoreFVS. 82:4 463-467, 2011] [24: 3 Visual Acuity ScoreVAS Visual Field ScoreVFS. 82:6 755- 758] [25: 4 WHO FVS Whole Person Impairment(WPI: 82:8 1069-1072 22) 5 Functional Field Score(FFS) 82:10 1339- 1341] [26: 6 82:12 1617- 1619 ] [27: FL-41 Tint Improves Blink Frequency, Light Sensitivity, and Functional Limitations in Patients with Benign Essential Blepharospasm Marcus K.BlackburnMD Randy D.LambMD Kathleen B.DigreMD A. GordonSmithMD Judith E.A.WarnerMD Robert W.McClaneMS Sanjeev D.NandedkarPhD Wendy J.LangebergMPH RichardHolubkovPhD Bradley J.KatzMD, PhD Ophthalmology Volume 116, Issue 5, May 2009, Pages 997-1001]
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Katz [footnoteRef:29] [29: Diagnosis, pathophysiology, and treatment of photophobia. Katz BJ, Digre KB. Surv Ophthalmol. 2016 Jul-Aug;61(4):466-77. doi: 10.1016/j.survophthal.2016.02.001. Epub 2016 Feb 12.]
15
FM(CM)(CTTH)[footnoteRef:30] [30: Fibromyalgia Among Patients With Chronic Migraine and Chronic Tension-Type Headache: A Multicenter Prospective Cross-Sectional Study. Cho SJ, Sohn JH, Bae JS, Chu MK. Headache. 2017 Nov;57(10):1583-1592. doi: 10.1111/head.13191. Epub 2017 Sep 22.PMID: 28940352]
(central sensitization)[footnoteRef:31])CA[footnoteRef:32] [31: Central sensitization in photophobic and non-photophobic migraineurs: possible role of retino nuclear way in the central sensitization process. Lovati C, Mariotti C, Giani L, D'Amico D, Sinelli A, De Angeli F, Capiluppi E, Bussone G, Mariani C. Neurol Sci. 2013 May;34 Suppl 1:S133-5. doi: 10.1007/s10072-013-1369-x.PMID: 23695062] [32: A touchy subject: an assessment of cutaneous allodynia in a chronic migraine population. Mathew PG, Cutrer FM, Garza I. J Pain Res. 2016 Feb 24;9:101-4. doi: 10.2147/JPR.S103238. eCollection 2016.PMID: 2695]
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calcium gene-related peptide receptor (CGRP)
Proton Magnetic Resonance Spectroscopy (1H-MRS) Korean J Intern Med. 2016 Nov; 31(6): 1171–1177.
This study compared rs-fc of affective pain-processing regions in CM with controls. Twelve minutes of resting-state blood oxygenation level-dependent data were collected from 20 interictal adult CM and 20 controls. Resting-state functional connectivity (rs-fc) between 5 affective regions (anterior cingulate cortex, right/left anterior insula, and right/left amygdala) Headache. 2013 May;53(5):737-51. doi: 10.1111/head.12081. Epub 2013 Apr 1.
.
Surv Ophthalmol. 2016 Jul-Aug;61(4):466-77.








182

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185
Blue and Red Light-Evoked Pupil Responses in Photophobic Subjects with TBI.
Phillip T. et al.
Optom Vis Sci 2017;94:108-117
TBIipRGCTBI2443.3; 581242.6; 58.10470nm1×1013phots// cm2625nm7×1013 phots // cm2flashing0.1Hzl30ipRGC 2
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187
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189
a touchy subject: an assessment of cutaneous allodynia in a chronic migraine population
Mathew PG, Cutrer FM, Garza I.
J Pain Res. 2016 Feb 24;9:101-4. doi: 10.2147/JPR.S103238. eCollection 2016.PMID: 2695
CA CA CAquantitative sensory testing (QST)CAn = 44CA CA90 CA
CA3ICHD-IIICA CA2,3311,62470CA CA CA93±3026160CA 12 CA
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190
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Central sensitization in photophobic and non-photophobic migraineurs: possible role of retino nuclear way in the central sensitization process
Lovati C, Mariotti C, Giani L, D'Amico D, Sinelli A, De Angeli F, Capiluppi E, Bussone G, Mariani C.
Neurol Sci. 2013 May;34 Suppl 1:S133-5. doi: 10.1007/s10072-013-1369-x.PMID: 23695062
456L. 38.2±13.265391ICHD-II126330248CM62.751.2;p = 0.035385CM84.184.5; p = NS 216169713239 2p = 0.08CM126106713520812
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193
Photophobia in primary headaches, in essential blepharospasm and in major depression.
Anagnostou E, Vikelis M, Tzavellas E, Ghika A, Kouzi I, Evdokimidis I, Kararizou E.
Int J Neurosci. 2017 Aug;127(8):673-679.
doi: 10.1080/00207454.2016.1231185. Epub 2016 Sep 13.PMID: 27580344

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195
Fibromyalgia Among Patients With Chronic Migraine and Chronic Tension-Type Headache: A Multicenter Prospective Cross-Sectional Study
Cho SJ, Sohn JH, Bae JS, Chu MK.
Headache. 2017 Nov;57(10):1583-1592. doi: 10.1111/head.13191. Epub 2017 Sep 22.PMID: 28940352




196

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