NFPA2004(1).pdf

NFPA 2001 (2004 Ed.)NFPA 2001 (2004 Ed.)Standard For Clean Agent

Extinguishing Systems

Presented by:Jeff L. Harrington, P.E.

For:SFPE Southeastern Chapter

January 20, 20042

KEY POINTSKEY POINTS

AGENT TOXICITY ISSUES (45 mins.) INERT AGENTS HALOCARBON AGENTS

CUP BURNER (2 mins.) NEW TASK GROUP

Q&A (13 mins.)

January 20, 20043

KEY TERMSKEY TERMS

Cardiac Sensitization

Asphyxiation NOAEL LOAEL PBPK Model Arterial Blood

Level

Cup Burner Value Design

Concentration Exposure Time Pre-Discharge

Alarm

January 20, 20044

INERT AGENT TOXICITYINERT AGENT TOXICITY

FIRE EXTINGUISHING PROCESS DISCHARGE INERT AGENT DISPLACES OXYGEN REDUCES OXYGEN TO ABOUT 12% FIRE CANT SUSTAIN COMBUSTION FIRE IS EXTINGUISHED LOW O2 LEVEL HARMFUL TO HUMANS

January 20, 20045


ASPHYXIATION VERY MISUNDERSTOOD FUNCTION OF O2% AND TIME TOO LITTLE OXYGEN (O2) OVER TOO MUCH TIME EQUALS DEATH

January 20, 20046


AGENT TRADE NAME CUP BURNER NOAEL LOAEL

ARGONITE 35 43 52FE-13 12.9 30 >50FE-25 8.7 7.5 10.0FM-200 6.6 9 10.5HALON 1301 4.1 5 7.5INERGEN 31 43 52NN100 31 43 52NOVEC 1230 4.5 10 >10

January 20, 20047


NFPA 2001 (2004 Ed) AGENT % - LTE 43 (GTE 12% O2)

OCCUPIED SPACES LTE 5 m. EXPOSURE AGENT % - GT 43 & LTE 52 (12 TO 10)

OCCUPIED SPACES LTE 3 m. EXPOSURE

January 20, 20048


NFPA 2001 (2004 Ed) AGENT % - GT 52 & LTE 62 (10 TO 8)

NOT OCCUPIED LTE 30 s. EXPOSURE AGENT % - GT 62 (LT 8)

NOT OCCUPIED SPACES NO EXPOSURE

January 20, 20049

HALOCARBON TOXICITYHALOCARBON TOXICITY

FIRE EXTINGUISHING PROCESS VARIES BETWEEN AGENTS HEAT ABSORBTION IS THE PRIMARY

MECHANISM GENERALLY, OXYGEN LEVELS REMAIN

AT SAFE LEVELS FOR HUMANS

January 20, 200410


CARDIAC SENSITIVITY HISTORY CARBON TETRICHLORIDE ARTERIAL BLOOD LEVEL PLUS ADRENALINE EQUALS HEART ARRHYTHMIA BREATHING = BLOOD LEVEL DISCHARGE = STRESS/ADRENALINE

January 20, 200411


CS TESTING BEAGLES SIX DOGS ON TREADMILL BREATHING AGENT % FOR 5 MINUTES SHOCKED WITH ADRENALINE HEART EFFECT MEASURED ARTERIAL BLOOD LEVEL MEASURED ONE OR MORE DOGS

January 20, 200412


NOAEL AND LOAEL CONCEPTS COST LIMITATIONS & DATA MARKET VIABILITY

January 20, 200413


AGENT TRADE NAME CUP BURNER NOAEL LOAEL

ARGONITE 35 43 52FE-13 12.9 30 >50FE-25 8.7 7.5 10.0FM-200 6.6 9 10.5HALON 1301 4.1 5 7.5INERGEN 31 43 52NN100 31 43 52NOVEC 1230 4.5 10 >10

January 20, 200414


ORIGINAL RULES TOO STRICT MARKET NEEDED RELAXATION COMMITTEE DEMANDED SCIENCE SCIENCE IS PBPK MODEL MODEL FULLY VALIDATED MODEL VERY CONSERVATIVE MODEL ALLOWS RELAXATION

January 20, 200415

HALOCARBON TOXICITYHALOCARBON TOXICITYOLD RULESOLD RULES

DESIGN CONCENTRATION

NORMALOCCUPANCY

EXPOSURE TIME LIMIT NOTES

HALOCARBONS 1996 Edition of NFPA 2001LTE NOAEL OCCUPIED NO LIMITGT NOAEL NOT OCCUPIED 0 SECONDS

GTE NOAEL OCCUPIED 0 SECONDS

EXCEPTION FOR CLASS B HAZARDS

January 20, 200416

People in building or space protected by flooding agent

Egress BeforeDischarge?

Fire Present Fire Drives RiskYes

Yes

No

No

No Exposure

UnintentionalExposure

Applicable Exposure Scenarios

Establish Safe Exposure Time

Exposure Scenarioof Interest

January 20, 200417

Overview of Process- Expose epinephrine treated dogsto FE agent via inhalation

- Determination lowest exposure concentration that causes cardiacsensitization (LOAEL in dog)

-Measure FE agent arterial blood levelattained during LOAEL exposure in dog

Determine critical arterialblood level of FE Agent

January 20, 200418

Chemical ExposureChamber

The lowest 5-minute FE Agentconcentration in dog arterial bloodat which cardiac sensitization is observed becomes the critical bloodconcentration. The critical bloodconcentration must not be reached orexceeded in humans exposed to the chemical.

FE Agent Concentration in Dog Arterial Blood During Inhalation

60

Time (minutes)

0

10

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30

40

50

0 1 2 3 4 5 6

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Epinephrine injected at 5-minpoint and cardiac responsenoted

FE Agent concentration in arterial blood measured at5-min point

Determination of the arterial blood level of HFC FE Agent duringcardiac sensitization test.

January 20, 200419




- Develop and validate human PBPKmodel.

- Use Monte Carlo simulation to describe individuals who take up FE agent quickly and to high levels.

- Use model to keep track of FE agentdistribution following inhalation


Simulate FE Agent concentrationin arterial blood of rapid/high uptake humans during inhalation exposure

January 20, 200420

7/15/1999 Gary W. Jepson, DuPont Haskell Laboratory 11

AlveolarSpace

QP

CI CX

QP

Slowly PerfusedTissue Group

Liver/MetabolizingTissue Group

Fat Tissue Group

CVL

Lung BloodQCCV

QCCA

CVFQFCA

CAQS

QLCA

CVS

Rapidly PerfusedTissue Group CA

QRCVR

Vm Km

January 20, 200421




- Develop and validate human PBPKmodel.

- Use Monte Carlo simulation to describe individuals who take up FE agent quickly and to high levels.

- Use model to keep track of FE agentdistribution following inhalation

- Exercise human PBPK modelunder exposure conditions of interestand determine time required to reach critical arterial blood concentrationof FE agent


Simulate FE Agent concentrationin arterial blood of rapid/high uptake humans during inhalation exposure

Determine time required to reachcriticalhuman arterial blood concentration of FE agent for a given exposure concentration

January 20, 200422

13.0%

10.0%

7.0%

Exposure Time (min)

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Simulation of Chemical Levels in Human Arterial Blood During Inhalation of FE Agent

Measured FE agent levelin arterial blood after inhaling the FE agent for 5 min at the LOAEL during the CS test

Measured FE agent levelin arterial blood after inhaling the FE agent for 5 min at the NOAEL during the CS test

January 20, 200423

Simulated Human Arterial Blood Levels of FE Agent During Inhalation

35.040.045.050.055.060.065.070.0

0.0 1.0 2.0 3.0 4.0 5.0

Time (Minutes)

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Target11.0%11.5%12.0%12.5%13.0%

Measured FE agent level in arterial blood after inhaling the FE agent for 5 min at the LOAEL during the CS test

January 20, 200424

PBPK FOR FMPBPK FOR FM--200200

.49 min.120,00012.0

.60 min.115,00011.51.13 min.110,00011.05.00 min.105,00010.55.00 min.100,00010.05.00 min.95,0009.55.00 min.90,0009.0

Human ExposurePpm%v/v

January 20, 200425

PBPK FOR FEPBPK FOR FE--2525

5.00 min.100,00010.0

0.49 min.135,00013.50.54 min.130,00013.00.59 min.125,00012.51.67 min.120,00012.05.00 min.115,00011.5

5.00 min.75,0007.5Human ExposurePpm%v/v

January 20, 200426

HALOCARBON TOXICITYHALOCARBON TOXICITYNEW RULESNEW RULES

DESIGN CONCENTRATION

NORMALOCCUPANCY EXPOSURE TIME LIMIT NOTES

HALOCARBONS 2004 Edition of NFPA 2001LTE NOAEL OCCUPIED 5 MINUTES NO PBPK NEEDED

GT NOAEL & LOAEL OCCUPIED

PBPK MODEL LIMIT CORRESPONDING TO DESIGN CONCENTRATION AND 5 MINUTES EXPOSURE NEED PBPK

GT NOAEL & LOAEL OCCUPIED

PBPK MODEL LIMIT CORRESPONDING TO DESIGN CONCENTRATION LESS THAN 5 MINUTES EXPOSURE

CONDITIONS:1. APPROVAL BY AHJ2. EGRESS CALCULATION PROOF3. ADHERE TO PBPK EXPOSURE LIMIT

LTE LOAEL NOT OCCUPIED 60 SECONDSNO PBPK MODEL DATA

GT LOAEL NOT OCCUPIED 30 SECONDSNO PBPK MODEL DATA

January 20, 200427

CUP BURNER TASK CUP BURNER TASK GROUPGROUP

INITIATED JANUARY 2004 INCREASE ACCURACY INCREASE REPEATABILITY ADDRESS INERT AGENTS DEFINE STANDARD APPARATUS DEFINE TESTING PROTOCOL

January 20, 200428

Q & AQ & A

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