INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) … · 2016. 9. 20. · Introduction . An...

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP)

INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Summary ReportSEIZED MATERIALS

2016/1

Table of contents

Samples Substances Concentrations Comments on substancesSample 1 Caffeine - Quantification not required

Cocaine 50.5 %

Sample 2 3,4-Methylenedioxymetamfetamine (MDMA) 13.8 %

Lactose - Quantification not required

Sample 3 Amfetamine 5.5 %

Caffeine - Quantification not required

Sample 4 [blank sample]

Test Samples Information

Samples Comments on samplesSample 1 SM-1 was prepared from a seizure containing 50.5 % (w/w) Cocaine base. The test sample also

contained caffeine and levamisole. Benzoylecgonine and cinnamoyl cocaine were also detected as minor components.

Sample 2 SM-2 was prepared from a seizure containing 13.8 % (w/w) MDMA. The test sample also contained lactose.

Sample 3 SM-3 was prepared from a seizure containing 5.5 % (w/w) Amfetamine base. The test sample also contained caffeine and creatine.

Sample 4 SM-4 wss a blank test sample prepared from plant material and contained no substances from the ICE menu

2016/1-SM Copyright (c) 2016 UNODC

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP)INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Sample 1 Analysis Page 6Identified substances Page 6Statement of findings Page 11Identification methods Page 20False positives Page 26Z-Scores Page 27Sample 2 Analysis Page 31Identified substances Page 31Statement of findings Page 36Identification methods Page 46False positives Page 52Z-Scores Page 53Sample 3 Analysis Page 56Identified substances Page 56Statement of findings Page 61Identification methods Page 70False positives Page 76Z-Scores Page 77Sample 4 Analysis Page 80Identified substances Page 80Statement of findings Page 82Identification methods Page 88False positives Page 94Z-Scores Page 95

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Introduction An important element of the UNODC International Quality Assurance Programme (IQAP) is the implementation of the International Collaborative Exercises (ICE). The exercises allow laboratories, from both developing and developed countries, to continuously monitor their performance in drug testing on a truly global scale. This report provides information on analytical results of laboratories participating in the Seized Materials (SM) group. In order to maintain confidentiality, the participating laboratories have been assigned random “Web Codes”, which change every round. The analytical results returned by laboratories participating in ICE are evaluated by UNODC and a confidential report is provided to each laboratory on its own performance. The overall analytical results are reviewed by the UNODC’s International Panel of Forensic Experts which oversees the implementation of these exercises, and offers guidance and support in addressing relevant quality issues. The exercises provide an overview of the performance and capacity of participating laboratories and enable UNODC to tailor technical support in the laboratory sector for greatest impact.

Comments from the International Panel of Forensic Experts

Participation of Laboratories In the 2016/1 round of the ICE programme, results were submitted within both the Seized Materials (SM) and Biological Specimens (BS) test groups by 220 laboratories in 68 countries. Within the SM test group, there were 183 participating laboratories from 65 countries and within the BS test group, results were submitted by 92 laboratories from 46 countries. Qualitative Analysis The analytical technique most commonly used for screening of test samples in the SM test group was the marquis reagent (40% of participants), while GC-MS (91% of participants) was the most commonly used technique for identification/confirmation of the components in the test samples followed by FTIR (43% of participants). The results for the qualitative identification of the controlled substances in the SM test group, the number of false positive/negative results and the analyses not performed are shown in the table 1.

Table 1. Performance of participants in the 2015/2 round of ICE.

Test sample SM-1 (Cocaine) SM-2 SM-3

SM-4 (blank) (MDMA) (Amfetamine)

Correct identification by participants 100% 98% 93% N/A

Number of false positives 3 4 7 14

Number of false negatives 0 2 9 -

Number of Analyses not performed 0 2 2 -

While the overall number of false positive/negative results reported by ICE participants is encouragingly low, laboratories reporting false positive or false negative results should investigate the reasons for this and corrective actions should be taken in order to continuously improve performance. There were only a total of four analyses not performed. ICE participants should note that test samples can contain any of the substances in the ICE menu and screening and identification carried out should take this into account. Quantitative Analysis The number of participants who carried out quantitative analysis, 126 (69%) for SM-1, 107 (58%) for SM-2 and 94 (51%) for SM-3 continues to be encouraging, particularly the high percentage of participants who quantified the cocaine in SM-1. It is also encouraging that 130 (71%) of participants in the SM test group

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performed quantitation and of these, 110 (84%) quantified more than one substance and 87 (67%) quantified all three test samples containing controlled substances. It is understood that quantitative analysis of controlled substances is often governed by local legislation and the requirements of prosecution. With regard to the analytical techniques used by participants performing quantitation, 53% used GC-FID, 29% used HPLC and 18% used mass spectrometry. z-scores obtained by participants in quantification are shown in table 2 below.

Table 2. Quantitative performance of participants in the 2016/1 round of ICE.

z-score

Test sample

SM-1 SM-2 SM-3 SM-4

(Cocaine) (MDMA) (Amfetamine) (Blank)

|z| < 2, satisfactory 83% 87% 81%

2 ≤ |z| ≤ 3, questionable 6% 8% 9%

|z| > 3, unsatisfactory 11% 5% 10%

According to the recommendations in ISO 13528:2005, an unsatisfactory z-score is considered to give an action signal and a questionable z-score is considered to give a warning signal. A single action signal or

warning signals in two successive rounds shall be taken that an anomaly has occurred that requires investigation. Participants with z-scores outside acceptable limits should review their quantification procedures. In the 2015/2 round of ICE, 16 laboratories obtained questionable z-scores with 2 ≤ |z| < 3. 13 of these laboratories participated and performed quantification in the 2016/1 round with 11, (84%) improving their performance and obtaining acceptable z-scores with |z| < 2 for at least one substance. Four of these laboratories also obtained questionable z-scores and five laboratories also obtained unsatisfactory z-scores

in 2016/1. 25 laboratories obtained unsatisfactory z-scores in ICE 2015/2 with |z| ≥ 3. Of these laboratories, 15 participated in ICE 2016/1 and performed quantification, with 14 (93%) improving their performance in at least one substance. Seven (47%) of these laboratories also obtained an unsatisfactory z-score in the

2016/1 round of the ICE programme Laboratories that need to perform quantitation routinely are encouraged to participate regularly in external proficiency testing or collaborative exercises such as the ICE programme. This will enable laboratories to assess the quality of their quantitative methods through the z-score values obtained. In addition to the use of z-scores as a measure of performance in quantitation, participants are encouraged to compare their results with the assigned values provided in individual quantification reports, to assess the accuracy of their quantitative performance. Laboratories reporting false positive or false negative results should investigate the root causes and corrective actions taken promptly in order to continuously improve performance. Participation in the ICE programme also helps in monitoring the effect of corrective actions. UNODC would like to acknowledge the valuable contribution of the Chemical Metrology Laboratory of the Health Sciences Authority, Singapore, for the provision of specific software used for the quantitative statistical calculations in the ICE programme.

New Psychoactive Substances (NPS) reported by laboratories participating in the 2016/1 round of the ICE programme During the 2016/1 round of ICE, participating laboratories provided information on NPS that had been identified in their laboratories. In total there were 214 reports of 136 substances. The most commonly reported substances were synthetic cathinones (33%) followed by synthetic cannabinoids (30%) as shown in figure 1.

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Figure 1. NPS reported by ICE laboratories during the 2016/1 round of ICE

In terms of the mechanism of action of the NPS reported by ICE participants, the predominant substances reported were stimulants (52%), while 30% were synthetic cannabinoid receptor agonists (SCRA’s) and 6% were dissociative substances as shown in figure 2.

Figure 2. Mode of action of NPS most commonly reported by ICE participants in the 2016/1 round of ICE

32%

33%

10%

15%

3% 5% 1% 1%

Synthetic cannabinoids

Synthetic cathinones

Phenethylamines

Others

Piperazines

Ketamine and phencyclidine typesubstances

Aminoindanes

Tryptamines

52%

30%

5%

4%

6% 3%

Stimulants

SCRAs

Hallucinogens

Sedatives/Hypnotics

Dissociatives

Opioids

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NPS most commonly reported by laboratories participating in ICE 2016/1 The substance most often reported by ICE participants was the stimulant ethylone followed by the dissociative ketamine and the synthetic cannabinoid receptor agonists 5F-AKB48 and 5F-MDMB-PINACA. For further details on these substances and others reported to the UNODC Early Warning Advisory, ICE participants can log on to the UNODC ICE portal and select the icon for the Early Warning Advisory on New Psychoactive substances as shown below.

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Codes and Abbreviations

Tech Code Name140 Colorimetric reactions

141 Marquis reagent (sulphuric acid, formaldehyde)

142 Cobalt thiocyanate

150 Thin Layer Chromatography

160 High/Ultra High Performance Liquid Chromatography

161 High Performance Liquid Chromatography with diode array detection

170 Gas Chromatography NPD

171 Gas Chromatography FID

172 Gas Chromatography ECD

180 Gas Chromatography/Mass Spectrometry

190 Fourier Transform Infrared Spectrometry

200 Spectrophotometry (visible, UV)

210 Others (specify)

211 NMR

220 Microcrystal test

230 Liquid chromatography/mass spectrometry

231 Liquid chromatography/tandem mass spectrometry

(+) “positive”: Indicates that the analyte is identified; for presumptive tests (e.g. colour reactions), indicates that a positive reaction was obtained.

(-) “negative”: Indicates that the analyte is not identified.

(ANP): Analysis not performed.



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Identified substances for Test Sample 1

Code Identified Substances00T0J0 cocaine

1GZVLB cocaina

2IQBJI cocaine

2MO2K2 cocaine

2Q2RKB Cocaine

331I33 Cocaine

3HKZSM Cocaine

3J30PJ Cocaina (pseudococaina)

3QY6YS cocaine

3UCRFA cocaine

43D6WO Cocaine, purity 52.7%

4EUEWU COCAINE

4LYNGL cocaine, caffeine

4PGIDD cocaine HCl

4Z40VI cocaine

55STC5 Cocaine

5NU8Q8 Cocaine

5XSWBZ cocaine

66BMCC cocaine

6AKET8 Cocaine

6DWSSS cocaine hydrochloride

6ILHTL Cocaine

6QO4X5 cocaine hydrochloride

6UM71W cocaine

77DRQT cocaine

7BTAAO Cocaine

7VKRTZ Cocaine

8F8I8T cocaine

8IHHJF COCAINA

8IXV43 Cocaine

8LZBLR Cocaine

8NM0BB Cocaine and Caffeine

8PHIP8 Cocaine Hydrochloride

8YMBJO Cocaine

91AIRR Cocaine

9EWNN5 Cocaine

A1O2PU cocaine

AA3A9G Cocaine

AAL7YF cocaine

AD2NVY COCAINE

Sample 1 Analysis



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Code Identified SubstancesAJO81E Cocaine and caffeine

ASUW2S Cocaine

AZCZ5Z cocaine

B54OW4 cocaine

BABKJE Cocaine

BAYYXO cocaine

BEUIGW Cocaina

BPJ4JR Cocaine hydrochloride

BT6Y0Y Cocaine

C7G4DH cocaine,

CE7TB2 Cocaine

CIFQC8 Cocaine

CSJXFO Cocaine

DALAM7 COCAINE

DWWWGY COCAINA

DY0EG9 cocaine

E8S7ZT Cocaine

EAE6LE Cocaine

EDUYDD Cocaine

EJBJCJ cocaine

ELQNHU Cocaine

ENI7TJ Cocaine

EXIP84 cocaine hydrochloride

EYAWUL Cocaine

EYAZVH Cocaine

F1M4VD Cocaine

F9I31B cocaine hcl

FJ44OK Cocaine

G1C7O1 Cocaine

GCHGCL Cocaine

GDGBEX Cocaine

GLYEEK cocaine

H7SE4O cocaine

HCVNSQ cocaine

HNG20U Cocaine 50.5% +/- 3.7%

HW0WRM Cocaine

IBPJLJ Cocaine hydrochloride, (caffeine and levamisole also present)

ICQNLB Cocaine

IIX7UR Cocaine, caffeine and Levamisole

ISA8Y8 Cocaine

IUW8JU Cocaine

IXUGYG Cocaine

J28855 COCAINE

J5YB55 Cocaine



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Code Identified SubstancesJJLJOU Cocaine, Caffeine, Levamisole

KBC4MU COCAINE

KHHK0G Cocaine

KJU4OU cocaine,caffeine

KLL25F Cocaine

KNZKKP cocaine

KTJBZA cocaine, methylecgonine, cis-trans cynnamoyl cocaine

KWPD3V cocaine

KYO332 Cocaine

L9LTEO Cocaine

LEPP7L cocaine and caffeine

LFCJGM Cocaine

LGECDN Cocaine

LLLLTB cocaine

LNR2DR Cocaine chlorydrate

M5LL0L cocaine

M9MFMP Cocaine, caffeine

MBOMMM cocaine HCl

MCOLDO cocaine

MOOSOO cocaine

MQXQRQ Cocaine

MVVNXZ Cocaine

NNNNDW Cocaine

O1DHE1 Cocaine mixed with caffeine and levamisole

O28H4R Cocaine

OF6Y6D cocaine

OFP7ET Cocaine

OOOIMO Cocaine

OOXOOI COCAINE

OSTFUT cocaine

OWRO6K Cocaine

OYX2R3 COCAINE

OZLPCC Cocaine

P3Y0QX cocaine

P5A5W5 Cocaine

P7ZPBP Yes Cocaine and Ketamine

PPPKPP Cocaine

QOMLQQ cocaine

QS88SU Cocaine

QUZQUQ Cocaine

QWO4OF COCAINE

R25T2B cocaine

R2XKWH Cocaine

R3QRYO Cocaine and Caffeine



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Code Identified SubstancesRC98IL COCAINE HCL

RV3YT3 Cocaine

S9YJGM COCAINE

SDFWC8 Cocaine HCl

SEF3EE Cocaine

SK102M cocaine

SLDIJQ cocaine

SSOFTB cocaine

T7YTFO cocaine

TBK0V2 MEFEDRONA, COCAINA

TDVDNQ Cocaine

TEZEE4 COCAINE, CAFFEINE, LEVAMISOL

TIKKKK Cocaine

TRQBQ8 COCAINE HCL

TSGAGB COCAINE, CAFFEINE

TWTWPH Cocaine

TWYAAL cocaine

U90SWA cocaine chlorhydrate

UFVIOP Cocaine

UQMBX2 COCAINE, CAFFEINE

UYPU5U Cocaine Hydrochloride

VFD46A cocaine

VKNECE Cocaine 52.28

VNZ61V COCAINE

VQT273 Cocaine

VXFBR6 Cocaine

VXXXL4 cocaine

VYZC85 cocaine

WDNNGN cocaine/MDMA

WDQWLH Cocaine

X2JISE Cocaine

X456G5 COCAINE, CAFFEINE

X70OZ9 cocaine

XFVW1V Cocaine

XNQ60K cocaine

XQJTD9 Cocaine

XRKU5U Cocaine

Y38I3T cocaine

YAH8BE cocaine

YAIIVO Cocaine Hydrochloride

YEKYTF cocaine

YXZMMX Cocaine

YY5Y1A Cocaine

YY7MQP cocaine, caffeine y levamisole



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Code Identified SubstancesYYZUYY Cocaine

Z5LF55 cocaine

Z887DL Cocaine

ZF1EFF Cocaine

ZFFEHN COCAINE 52.9%, CAFFEINE

ZH0THY Cocaine

ZOIJZ3 COCAINE

ZRG6U6 cocaine

ZSX0SS Cocaine

ZXIIII Cocaine



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Code Caffeine Cocaine 00T0J0 + +

Sample was found to contain cocaine-HCl, anhydrecgonine methylester, pseudo ecgonine methyl ester, caffein and levamisole

1GZVLB + +

2IQBJI + +found cocaine with 48.2%w/w

2MO2K2 + +./.

2Q2RKB + +Cocaine and Caffeine confirmed

331I33 + +Caffeine, levamisole, trans-cinnamoyl cocaine, methylecgonine

3HKZSM + +Mixture of cocaine, caffeine and Levamisole.

3J30PJ - +contiene adulterantes como la Cafeina y Levamisol

3QY6YS ANP +

3UCRFA + +the sample contains a mixture cocaine and caffeine

43D6WO + +Cocaine is a Class A drug subject to the provisions of the Misuse of Drugs Act 1971

4EUEWU - +The sample 2016/1/SM-1 was found to contain the illicit drug COCAINE.

4LYNGL + +The sample contains also levamisole. The cocaine is scheduled as illicit drug in XXXX. The caffeine and the levamisole are cutting agents.

4PGIDD + +The sample contains cocaine, caféine and lévamisole.Cocaine is sheduled as illicit drug.

4Z40VI + +cocaine, levamisole, caffeine, ecgonine methyl ester, ecgonidine methyl ester, cis/trans-cinnamoyl cocaine, tropacocaine-GCMS-compare mass spectra with library, retention time of reference sample and FTIR-cocaine

55STC5 + +

5NU8Q8 + +The powder was analysed and found to contain cocaine hydrochloride and caffeine.

5XSWBZ + +cocaine and caffeine, levamisole

66BMCC - +found cocaine with 59.79% w/w in SM-1

6AKET8 + +SM-1 found to contain Cocaine

6DWSSS + +white powder containing cocaine, caffeine and levamisol as diluents and ecgonidine methyl ester and ecgonine methyl ester as cocaine impurities

Statement of findings for Test Sample 1



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Code Caffeine Cocaine 6ILHTL + +

The sample contained 49.56% w/w cocaine (base) Substances detected include caffeine and tetramisole

6QO4X5 + +cocaine base 50,5 %

6UM71W + +Cocaine is controlled by KB 31/12/1930

77DRQT + +COCAINE Hydrochloride 49.4% AS BASE - CAFFEINE - LEVAMISOLE

7BTAAO ANP +There was evidence of cocaine

7VKRTZ + +This sample is cocaine.

8F8I8T + +Caffeine, levamisole, ecgonidine.

8IHHJF + +

8IXV43 + +A sample of the powder was found to contain cocaine at a purity of 52%. This sample was also found to contain caffeine and tetramisole.

8LZBLR - +SM-1 to contain Cocaine

8NM0BB + +The Test sample 2016/1/SM-1 was analyzed by Colour test and Thin Layer Chromatography technique and found to contain Cocaine and Caffeine.

8PHIP8 + +A sealed glass vial containing a white powder. This powder contained an average of 57% Cocaine Hydrochloride.

8YMBJO + +The sample consist controlled drugs - cocaine

91AIRR + +

9EWNN5 + +the item 1 is a powder with cocaine hydrocloride, caffeine and levamisole. The percent of free base psycoactive substance cocaine is 55.7% .

A1O2PU ANP +white powder and typical smell

AA3A9G + +White powder containing Cocaine. Also detected Levamisole and Caffeine

AAL7YF + +Colorimetrics reactions showed positive results for substances like alcaloids that was confirmed by GC-MS. COcaine, caffeine and levamisole was detected an identified.

AD2NVY + +LEVAMISOL, CAFFEINE

AJO81E + +

ASUW2S + +The sample contains 51.5% ± 1.5%Also contain caffeine and levamisole

AZCZ5Z + +cocaine and caffeine



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Code Caffeine Cocaine B54OW4 + +

white powder containing cocaine (51.4%w/w), caffeine and levamisole

BABKJE + +The powder, which weighed 0.21 grams, was analysed and found to contain Cocaine.A sample of the powder was further analysed and found to contain 51% (weight for weight) Cocaine.Cocaine is a class A controlled drug within the provisions of the Misuse of Drugs Act 1971.

BAYYXO + +Sample contains cocaine hydrochloride, tetramisole and caffeine.

BEUIGW + +La muestra contiene Cocaína.

BPJ4JR + +It has been detected the presence of cocaine hydrochloride in the sample

BT6Y0Y + +Sample 2016/1/SM-1 consists of white powder. Cocaine, a prohibited substance included in the National Law forNarcotics, is found to be present in this sample.

C7G4DH + +Levamisole, Caffeine

CE7TB2 + +The sample contains cocaine. The content of cocaine (as cocainehydrochloride) is determined to 58 %. Cocaine is a controlled substance in X.

CIFQC8 + +Sample 2016/1/SM-1, a white odourless powder, gave a positive result for cocaine, a controlled substance under national legislation on drugs.

CSJXFO + +Examination revealed the presence of cocaine.

DALAM7 + +The sample 1 contains cocaïne chlorhydrate at 53% per weight (47% base), which is a controlled substance in XXXX.

DWWWGY + +COCAINA BASE, CAFEINA, LEVAMIZOL

DY0EG9 + +the results of the screening test "TLC (Tech:150)" and identification , confirmation analytic techniques HPLC (160) and GC/MS (180).

E8S7ZT ANP +2016/1/SM-1 contient en plus de la cocaine des composés insolubles dans le methanol. Il y a un composé non identifié qui est commun à 2016/1/SM-1 et 2016/1/SM-3 qui apparâit par la technique 150 (Chromatographie sur couche mince).

EAE6LE + +The sample contains Cocaine and Caffeine. The content of Conaine as base is 49.3%

EDUYDD + +The sample contains cocaine which is listed as a controlled drug according to XXX order, appendix I of February 22nd 1990.

EJBJCJ + +In the test sample 2016/1/SM-1 were detected cocaine, caffeine and levamisole

ELQNHU + +Based on the above analysis, the sample was found to contain cocaine, levamisole and caffeine.

ENI7TJ + +From screening test using (CT), (FTIR) and ion scan and from confirmatory test using (GC-MS), the sample was found to contain the controlled drug Cocaine.



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Code Caffeine Cocaine EXIP84 + +

Sample also contain caffeine and levamisole. The presence of drug confirmed by GC-MS and FTIR spectroscopy analysis.The hydrochloride form of cocaine was confirmed by the anion analysis and FTIR spectroscopy.

EYAWUL + +SM1 contains Cocaine, Caffeine and Levamisol.Methyecgonine an cinnamoylcocaine werw detected as minor components.

EYAZVH + +The sample contains a controlled substance as cocaine and other substances besides cutting caffeine and levamisol.

F1M4VD + +Cocaine was identified by TLC and GC-MS.

F9I31B + +cocaine, anhidromethylecgonine, cis&trans cinnamoilecgonine, caffeine,levamisole. BASE COCAINE 50,14+/-1,3 % (w/w)

FJ44OK + +

G1C7O1 + +Caffeine and Levamisol

GCHGCL + +Sample contains 52.6 ± 2.2 % Cocaine base. Caffeine and levamisole were also detected

GDGBEX + +Sample SM-1 was found to contain cocaine.

GLYEEK + +The sample 2016/1/SM-1 contains cocaine (53,4 %), caffeine and levamisole

H7SE4O + +Adulterantes: cafeína y levamisol

HCVNSQ + +cocaine,caffeine,levomisole

HNG20U + +Was found Caffeine, levanisole and trace of Benzoilecgonine

HW0WRM + +

IBPJLJ + +The powder contained cocaine Hydrochloride, together with the adulterants caffeine and levamisole

ICQNLB + +Powder from test sample 2016/1/SM-1 contain cocaine with caffeine and tetramisol

IIX7UR + +Cobalt thiocyanate (CT) positive. GC/MS Retention time and mass charge ratio (M/Z), similar characteristics whit the subtances used as standar or pattern.

ISA8Y8 + +Sample 2016/1/SM-1 found to contain cocaine and caffeine

IUW8JU + +De los análisis realizados, se concluye que la sustancia se trata de cocaína

IXUGYG + +-

J28855 + +COCAINE, CAFEINE AND LEVAMISOLE

J5YB55 + +Cocaine HCl. Caffeine and levamilole-tetramisole were also identified.



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Code Caffeine Cocaine JJLJOU + +

in the sample labeled as 2016/1 / SM-1 they were found cocaine, caffeine and levamisole.

KBC4MU + +White powder that contains controlled substance COCAINE and adulterant CAFFEINE.

KHHK0G + +The sample was found to contain 52.1% of cocaine (as base). The sample was also found to contain caffeine and levamisole/tetramisole (isomeric form not determined).

KJU4OU + +Blue colour appear with Cobalt Thiocyanate test and blue colour appear in the lower layer by Modified Cobalt Thiocyanate test which indicates possible presence of Cocaine.Amalic Acid test indicates possable presence of Caffeine.Analysis of GCMS shows the similarity as Cocaine and Caffeine.During quantitative analysis,absebce of reference standard is the challenge for us.

KLL25F + +From GCMS analysis, cocaine and caffeine were detected

KNZKKP + +

KTJBZA + +The test sample also contained levamisole and caffeine

KWPD3V + +cocaine was detected by GC/MS screening nad it was quantified by GC/FID

KYO332 + +It is an usually detected drug in our laboratory.

L9LTEO + +Test Sample 2016/1/SM-1 contains Cocaine, a dangerous drug. It also contains caffeine, levamisole, benzoylecgonine, cinnamoyl cocaine and methyl ecgonine.

LEPP7L + +

LFCJGM + +ontained cocaine, caffeine, levamisole, cinnamoilcocaine, cis-cinnamoilcocaine and trace of

methylecgonidine, methylecgonine

LGECDN + +The sample contains cocaine (54,8%), caffeine and levamisole.

LLLLTB + +The test sample number SM-1 containing a psycho narcotic drug cocaine.

LNR2DR + +levamisole, caffeine

M5LL0L ANP +

M9MFMP + +screening by colorimetric testconfirmation by GC-MS and FTIRquantification by GC-MS

Other substances in the sample: levamisoleMBOMMM + +

caffeine, levamisole

MCOLDO ANP +

MOOSOO + +Test sample 2016/1/SM-1 contains cocaine base 51.0 %, m/m, caffeine and cocaine related compounds.



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Code Caffeine Cocaine MQXQRQ + +

In Sample 1 was identified cocaine and caffeine, levamisole.

MVVNXZ ANP +The white powder contains Cocaine.

NNNNDW + +It contain 48.6 % of Cocaine and also contains Caffein, Levamisole/Tetramisole and traces of Benzoylecgonine

O1DHE1 + +the sample was confirmed by GC MS and quantified by GC FID

O28H4R - +GC-MS

OF6Y6D + +

OFP7ET + +CaffeineLevamisole

OOOIMO + +Cocaine, conc. 50% as free base, other substances found are caffeine and tetramisol

OOXOOI + +COCAINE

OSTFUT + +caffeine

OWRO6K + +Cocaine and Caffeine were identified.

OYX2R3 + +COCAINA CLORHIDRATO + CAFEINA+ LEVAMISOL

OZLPCC ANP +

P3Y0QX + +white powder containing 58.1%w/w of cocaine

P5A5W5 + +Presence of cocaine, concentration of 49.68%, with the presence of the following adulterants: caffeine, levamisole. We detected even the presece of Methyl-egonina, Methyl-egonidina, Cynnamoilcocaina.

P7ZPBP - +A preliminary test SCOTT and MARQUIS to know what kind of drugs were present in the samples that have been sent and two confirmation tests TLC and GC-FID. In the case of the sample referenced with the code 2016/1/SM-1 was able to verify the presence of Cocaíne Scott test and other tests it was also verified the presence of Cocaíne and Ketamine

PPPKPP + +Powder was analysed and found to contain cocaine, levamisole and caffeine.

QOMLQQ +

QS88SU + +The sample contained 52.3% cocaine. Additionally caffeine and levamisol was detected int the sample.

QUZQUQ + +Mass spectrometry profile correlation between sample and reference material certified

QWO4OF + +



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Code Caffeine Cocaine R25T2B + +

We diluited 1 mg of the sample in 10 mL of methanol and analized by CG-MS.

R2XKWH - +

R3QRYO + +Nil

RC98IL + +SM1 was prepared from a seizure containing 54% w/w cocaïne base. Thesample also contained caffeine and levamisole

RV3YT3 + +Powder containing cocaine, additionally identified caffeine and levomisole

S9YJGM + +The results of the test of SM1 (142) received confirmed that the mentioned simple contains cocaine with 49.5 percentage by weight (49.5%). The sample 1 also contains caffeine as not controlled drugs.

SDFWC8 + +additional substance: caffeine, levamisol

SEF3EE + +The sample contained cocaine HCl. In addition to that, caffeine,Levamisole, norcocaine, cinnamoylcocaine and trans-cinnamoylcocaine were identified. Analysis revealed percentage of cocaine base is 41.82%.

SK102M + +

SLDIJQ + +the sample is mixture of cocaine, caffeine,cis-cynamoylcocaine and imidazol

SSOFTB + +Presence of cocaine: retention time and MS spectra in GC analysis (FID and MS), DRX and FTIR analysis. Cocaine as hydrochloride.Presence of caffeine and levamisole: retention time and MS spectra in GC analysis (FID and MS) and XRD analysis. Caffeine as base.

T7YTFO + +

TBK0V2 ANP +SUSTANCIAS DISUELTAS EN METANOL E IDENTIFICADAS MEDIANTE CG/FID

TDVDNQ + +x grams of powder containing 51% cocaine . Caffeine and levamisole were also present

TEZEE4 + +We determined a mixture of Cocaine, Caffeine and Levamisol. The Cocaine concentration is 54.6 %w/w this is an average of two measures.

THQ2CH + +

TIKKKK + +SM-1 contains cocaine

TRQBQ8 + +CAFEINLEVAMISOLECOCAIN IMPURITIES

TSGAGB + +The 2016/1/SM-1 Sample was found to contain Cocaine and Caffeine.

TWTWPH + +



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Code Caffeine Cocaine TWYAAL + +

The sample contains cocaine, caffeine, levamisole

U90SWA + +quantification HPLC : 49 %

UFVIOP + +The sample contains Cocaine and Caffeine.

UQMBX2 + +WHITE POWDER SAMPLE ANALYZED CONTAINS COCAINE AND CAFFEINE

UYPU5U + +220 milligrams of a white powder containing cocaine hydrochloride and caffeine. This white powder contained an average of 50% of cocaine (purity has been calculated in the base form).

VFD46A + +the SM-1 sample contains 64.6% of cocaine cut by the caffeine and lactose

VKNECE + +After analyzing the sample with CR, MSD confirmation and subsequent cuantification with FID, we can confirm that sample contents cocaine, levamisole and caffeine.

VNZ61V - +THE SAMPLE CORRESPOND COCAINE MIIXED WITH CAFFEINE AND LEVAMISOL

VQT273 + +Caffeine, levamisole

VXFBR6 + +cocaine - 51.93%, ecgonidine methyl ester, cis-cinnamoylcocaine, caffeine, levamisole

VXXXL4 + +the white powder contains cocaine (43,97%) wich is controlled by national law. In addition caffeine and levamisole were found in the sample.

VYZC85 + +cocaine is on the list of drugs

WDNNGN + +after chemical analysis was performed the sample was found to contain1/ cocaine 57.4 %2/ MDMA 0.05 %3/ caffiene

WDQWLH + +Powder containing cocaine

X2JISE + +Tetramisol and caffeine were also detected

X456G5 + +

X70OZ9 + +

XFVW1V + +In this Sample Contain three substance Cocaine ,Caffeine and Sugar

XNQ60K + +

XQJTD9 + +Cocaine existed in salt form. We found caffeine in the sample

XRKU5U + +On analysis, I found the sample "SM-1" containing Cocaine and Caffeine.



20

Code Caffeine Cocaine Y38I3T ANP +

En la muestra SM-1, se encontra la presencia de cocaina, tambien se realizola preuba para cloruras

YAH8BE + +caffeine, levamisole

YAIIVO + +Cocaine hydrochloride, caffeine, and phenyltetrahydroimidazothiazole confirmed in 1 unit tested of 1 unit received.

YEKYTF + +powder contains cocaine with caffeine and levamisole

YXZMMX + +Cocaine is a controlled drug. Indications of caffeine and levamisole.

YY5Y1A + +Results of screening tests were positive for cocaine. Retention time and fragmentation pattern obtained with sample are equivalent to those obtained with cocaine. Cocaine was detected at 52.6% by weight.

YY7MQP + +

YYZUYY + +The sample contains 52,07 % cocaine ( as free base)

Z5LF55 + +the powder is a mixture of cocaine hidrochloride and caffeine. The concentration of cocaine (base) in the sample is 52.1% by weight.

Z887DL + +The test sample 2016/1/SM-1 was found to contain the controlled drug cocaine. The test sample was also found to contain caffeine.

ZF1EFF + +Presence of cocaine hydrochloride was detected in the sample. The sample also contained caffeine, levamisole and multitude of trace level alkaloid impurities: (cis/trans)cinnamoylcocaine, benzoylecgonine, methylecgonine, ethylecgonine.

ZFFEHN + +

ZH0THY + +Cocaine, caffeine, levamisole, methilesterecgonine, cinnamoilcocaine, 48% +/- 4

ZOIJZ3 + +

ZRG6U6 + +Analysis of a representative sample of the powder revealed the presence of cocaine with a purity of approximately 59% (calculated as base).

ZSX0SS + +One glass bottle containing 0.22 grammes of a solid containing 0.11 grammes of cocaine.

ZXIIII + +Cocaine, caffeine and levamisol



21

Identification methods for Test Sample 1

Code 140 141 142 150 160 161 171 180 190 200 211 220 230 231 210

00T0J0 S I I I I

1GZVLB SI SI SI I

2IQBJI SI

2MO2K2 I SI SI

2Q2RKB S S S I I

331I33 SI

3HKZSM I I S Raman

3J30PJ S SI I I I

3QY6YS I SI

3UCRFA S S S I I

43D6WO S S I

4EUEWU S I

4LYNGL S I I

4PGIDD I SI

4Z40VI S S SI I

55STC5 SI

5NU8Q8 S I I

5XSWBZ I SI

66BMCC I S I

6AKET8 S S I

6DWSSS SI I

6ILHTL S S S I I

6QO4X5 S I I

6UM71W I SI

77DRQT S S S I I

7BTAAO SI I

7VKRTZ S I I

8F8I8T S S I S

8IHHJF S S I I

8IXV43 SI SI I I I I

8LZBLR S S S SI I

8NM0BB S S SI S Fast Blue B Salt test

8PHIP8 S S I I

8YMBJO I SI

Analytical Technique Codes

Legend: S ... used for Screening I ... used for Identification SI ... used for both



22

Code 140 141 142 150 160 161 171 180 190 200 211 220 230 231 210

91AIRR I SI

9EWNN5 I

A1O2PU SI

AA3A9G S SI SI SI

AAL7YF S S S I I

AD2NVY I SI

AJO81E SI I HPLC-RID

ASUW2S S I I

AZCZ5Z SI I

B54OW4 I SI

BABKJE S I

BAYYXO S S S SI I I S microscopic and macroscopic examination

BEUIGW S S S I I

BPJ4JR I S I

BT6Y0Y S S I I

C7G4DH S SI SI I

CE7TB2 I I

CIFQC8 S S S I

CSJXFO SI

DALAM7 SI

DWWWGY

S S S I I

DY0EG9 S I I S

E8S7ZT S S I

EAE6LE S S S SI I

EDUYDD I I

EJBJCJ I

ELQNHU S I I

ENI7TJ S S I I S Negm's test

EXIP84 S I I

EYAWUL S I

EYAZVH S I SI

F1M4VD S S S I I

F9I31B S S S I I I RDX

FJ44OK SI

G1C7O1 S I I I

GCHGCL S I SI I

GDGBEX S I I

GLYEEK S S S I S tanred



23

Code 140 141 142 150 160 161 171 180 190 200 211 220 230 231 210

H7SE4O I I SI

HCVNSQ SI SI SI SI I SI I

HNG20U S S I I

HW0WRM

S S S I

IBPJLJ S S S I I

ICQNLB S S I I

IIX7UR S S S I

ISA8Y8 S I

IUW8JU S SI SI macroscopic analysis

IXUGYG SI

J28855 S I I

J5YB55 I SI I

JJLJOU I I SI

KBC4MU S S SI I I S Simon

KHHK0G SI I LC/ELSD

KJU4OU S I

KLL25F S I

KNZKKP SI

KTJBZA I I

KWPD3V SI

KYO332 S I I I Fehling Reagent

L9LTEO S S S I I I Duquenois-Levine reagent

LEPP7L S S S I I

LFCJGM SI

LGECDN S S S I I

LLLLTB I SI S I SI

LNR2DR SI SI

M5LL0L I

M9MFMP S S I I

MBOMMM

SI

MCOLDO I I S not stated

MOOSOO I SI

MQXQRQ I I

MVVNXZ S S S I I

NNNNDW SI I

O1DHE1 I I SI

O28H4R SI

OF6Y6D I SI



24

Code 140 141 142 150 160 161 171 180 190 200 211 220 230 231 210

OFP7ET S S S I I

OOOIMO SI

OOXOOI S S S I I

OSTFUT S SI SI I

OWRO6K S I I

OYX2R3 S S I I S RAMAN

OZLPCC SI I S SI Rapid Test

P3Y0QX I SI

P5A5W5 I I

P7ZPBP S S S I I

PPPKPP S S S I I

QOMLQQ S S S I

QS88SU I I SI I

QUZQUQ I I

QWO4OF SI S S I

R25T2B SI

R2XKWH I S

R3QRYO S I

RC98IL I I

RV3YT3 SI

S9YJGM S S S I I

SDFWC8 SI I

SEF3EE S S I I I S fast blue B salt test

SK102M S S I S microscopy

SLDIJQ SI I I I I

SSOFTB I I SI I XRD

T7YTFO S I I

TBK0V2 I I S

TDVDNQ S S I I

TEZEE4 SI S S SI I I I

THQ2CH S S S SI I I I I

TIKKKK S S S I I S

TRQBQ8 SI

TSGAGB I SI

TWTWPH I S

TWYAAL S S I I SI

U90SWA SI I

UFVIOP SI I

UQMBX2 S S S I I



25

Code 140 141 142 150 160 161 171 180 190 200 211 220 230 231 210

UYPU5U S S I I I Ehrlich

VFD46A S I I I I HPLC/RID

VKNECE SI I

VNZ61V I SI

VQT273 S I

VXFBR6 I SI

VXXXL4 I SI

VYZC85 I I S I

WDNNGN SI

WDQWLH S S S I

X2JISE I

X456G5 SI

X70OZ9 I

XFVW1V S I I

XNQ60K SI I

XQJTD9 S I I

XRKU5U S I I

Y38I3T SI SI SI

YAH8BE I SI SI

YAIIVO SI I I

YEKYTF SI I

YXZMMX I I

YY5Y1A S S S I

YY7MQP S S S I I

YYZUYY SI

Z5LF55 I I I SI I xrd

Z887DL S S S I I

ZF1EFF S I I I I

ZFFEHN S S S SI I SI

ZH0THY S S S I

ZOIJZ3 S S SI

ZRG6U6 S S S I I

ZSX0SS S S SI

ZXIIII S I



26



Frequency of use of screening and identification techniques:

Summary for test sample 1The response summary of all 183 participating laboratories for the identification of SM-1, frequency of use of screening andidentification techniques and false positives and negatives:

Identification of test sample 1:

False positives for Test Sample 1

Code Name Technique

Response Summary Participants: 130

171

False negatives for SM-1 (techinque(s) used or ANP)

There were no false negative results or ANP for the cocaine in SM-1

142 150 160 161 190 200 220


P7ZPBP Ketamine 150/171

TBK0V2 Mephedrone

WDNNGN MDMA 180

Response SummaryParticipants: 183

Caffeine: 164

Cocaine: 183

Section 211 230 231


Section 140 141 142 150 160 161 171 180 190 200 211 220 230 231 210

Screening 66 73 60 22 0 1 4 61 17 2 0 1 0 0 11

36.3% 40.1% 33.0% 12.1% 0.0% 0.5% 2.2% 33.5% 9.3% 1.1% 0.0% 0.5% 0.0% 0.0% 6.0%

Identification 14 6 4 36 8 15 29 165 72 4 3 0 5 1 12

7.7% 3.3% 2.2% 19.8% 4.4% 8.2% 15.9% 90.7% 39.6% 2.2% 1.6% 0.0% 2.7% 0.5% 6.6%

# labs using this technique

71 75 61 45 8 15 30 165 79 6 3 1 5 1 2139.0% 41.2% 33.5% 24.7% 4.4% 8.2% 16.5% 90.7% 43.4% 3.3% 1.6% 0.5% 2.7% 0.5% 11.5%


27



Concentration (mass%)

Deviation from robust average

z-scoreConcentration

(mass%)

Deviation from robust

averagez-score

3UCRFA 26.0 -25.7 -10.1 J5YB55 51.4 -0.3 -0.1SLDIJQ 33.2 -18.5 -7.2 LEPP7L 51.4 -0.3 -0.14EUEWU 40.0 -11.7 -4.6 ASUW2S 51.5 -0.2 -0.1O1DHE1 40.0 -11.7 -4.6 5XSWBZ 51.6 -0.1 -0.1SEF3EE 41.8 -9.9 -3.9 AJO81E 51.6 -0.1 -0.1WDQWLH 42.1 -9.6 -3.8 AD2NVY 51.6 -0.1 -0.1KNZKKP 43.0 -8.7 -3.4 BEUIGW 51.6 -0.1 -0.1VXXXL4 43.9 -7.8 -3.1 KYO332 51.6 -0.1 -0.1ZOIJZ3 44.5 -7.2 -2.8 TIKKKK 51.6 -0.1 -0.1OYX2R3 46.3 -5.4 -2.1 ZSX0SS 51.7 0.0 0.0DALAM7 47.0 -4.7 -1.9 QUZQUQ 51.7 0.0 0.091AIRR 47.1 -4.6 -1.8 UFVIOP 51.8 0.1 0.0AAL7YF 47.5 -4.2 -1.7 J28855 51.9 0.2 0.1ZH0THY 48.0 -3.7 -1.5 VXFBR6 51.9 0.2 0.18YMBJO 48.1 -3.6 -1.4 VYZC85 51.9 0.2 0.12IQBJI 48.2 -3.5 -1.4 OOXOOI 52.0 0.3 0.1ZXIIII 48.5 -3.3 -1.3 4LYNGL 52.0 0.3 0.1NNNNDW 48.6 -3.1 -1.2 EDUYDD 52.0 0.3 0.1VQT273 48.8 -2.9 -1.2 IBPJLJ 52.0 0.3 0.1U90SWA 49.0 -2.7 -1.1 MBOMMM 52.0 0.3 0.1EAE6LE 49.3 -2.4 -1.0 QOMLQQ 52.0 0.3 0.177DRQT 49.4 -2.3 -0.9 YYZUYY 52.1 0.4 0.1S9YJGM 49.5 -2.2 -0.9 KHHK0G 52.1 0.4 0.16ILHTL 49.6 -2.1 -0.9 LNR2DR 52.1 0.4 0.1TRQBQ8 49.6 -2.1 -0.8 Z5LF55 52.1 0.4 0.1P5A5W5 49.7 -2.0 -0.8 CE7TB2 52.2 0.5 0.2OOOIMO 49.7 -2.0 -0.8 HW0WRM 52.2 0.5 0.2XQJTD9 49.7 -2.0 -0.8 X70OZ9 52.2 0.5 0.2SSOFTB 49.9 -1.8 -0.7 VKNECE 52.3 0.6 0.2KTJBZA 50.0 -1.7 -0.7 QS88SU 52.3 0.6 0.2UYPU5U 50.0 -1.7 -0.7 TWTWPH 52.3 0.6 0.2EXIP84 50.1 -1.6 -0.7 8IXV43 52.3 0.6 0.2LFCJGM 50.1 -1.6 -0.6 7VKRTZ 52.4 0.7 0.3RV3YT3 50.1 -1.6 -0.6 1GZVLB 52.5 0.8 0.3F9I31B 50.1 -1.6 -0.6 DWWWGY 52.5 0.8 0.3HNG20U 50.5 -1.2 -0.5 GCHGCL 52.6 0.9 0.3A1O2PU 50.5 -1.2 -0.5 YY5Y1A 52.6 0.9 0.3YEKYTF 50.5 -1.2 -0.5 43D6WO 52.7 1.0 0.4SK102M 50.8 -0.9 -0.4 3HKZSM 52.8 1.1 0.4FJ44OK 50.9 -0.8 -0.3 MQXQRQ 52.8 1.1 0.46QO4X5 50.9 -0.8 -0.3 HCVNSQ 52.9 1.2 0.58PHIP8 51.0 -0.7 -0.3 ZFFEHN 52.9 1.2 0.5BABKJE 51.0 -0.7 -0.3 YXZMMX 53.1 1.4 0.5TDVDNQ 51.0 -0.7 -0.3 GLYEEK 53.4 1.7 0.6YAIIVO 51.0 -0.7 -0.3 BAYYXO 53.5 1.8 0.7MOOSOO 51.1 -0.6 -0.2 00T0J0 53.5 1.8 0.7QWO4OF 51.2 -0.5 -0.2 OFP7ET 53.5 1.8 0.72MO2K2 51.2 -0.5 -0.2 H7SE4O 53.5 1.8 0.7BPJ4JR 51.3 -0.4 -0.2 EJBJCJ 53.7 2.0 0.8ZF1EFF 51.3 -0.4 -0.2 R25T2B 54.0 2.3 0.9B54OW4 51.4 -0.3 -0.1 RC98IL 54.0 2.3 0.9

Code

Cocaine

Code

Cocaine

28





averagez-score

4PGIDD 54.1 2.4 0.96UM71W 54.3 2.6 1.0EYAZVH 54.3 2.6 1.0SDFWC8 54.4 2.7 1.0OF6Y6D 54.4 2.7 1.0TEZEE4 54.6 2.9 1.1IXUGYG 54.8 3.1 1.2KWPD3V 54.8 3.1 1.2LGECDN 54.8 3.1 1.2

F1M4VD 54.9 3.2 1.26DWSSS 55.0 3.3 1.3G1C7O1 55.0 3.3 1.39EWNN5 55.7 4.0 1.5X2JISE 57.2 5.5 2.1

WDNNGN 57.4 5.7 2.2P3Y0QX 58.1 6.4 2.5ZRG6U6 59.0 7.3 2.866BMCC 59.8 8.1 3.25NU8Q8 61.0 9.3 3.6VFD46A 64.6 12.9 5.0M9MFMP 67.5 15.8 6.23QY6YS 74.0 22.3 8.7KJU4OU 83.0 31.3 12.2MCOLDO 85.6 33.9 13.2

Cocaine

Code

29

Substance: SM-1; Cocaine

Round: 2016/1

Z-Score Report per Sample per SubstanceRobust average = 51.7%UNODC value = 50.5%

‐3.8

‐3.4

‐3.1

‐2.8

‐2.1

‐1.9 ‐1.8 ‐1.7‐1.5 ‐1.4 ‐1.4 ‐1.3 ‐1.2 ‐1.2 ‐1.1 ‐1

.0 ‐0.9 ‐0.9 ‐0.9

‐0.8 ‐0.8

‐0.8

‐0.8 ‐0.7 ‐0.7

‐0.7 ‐0.7

‐0.6

‐0.6

‐0.6 ‐0

.5‐0.5

‐0.5 ‐0.4 ‐0.3

‐0.3 ‐0.3

‐0.3

‐0.3

‐0.3 ‐0.2 ‐0.2

‐0.2 ‐0.2

‐0.2 ‐0.1

‐0.1

‐0.1 ‐0.1 ‐0.1

‐0.1

‐0.1

‐0.1

‐0.1

‐0.1 0.0

0.0 0.0 0.1

0.1

0.1

0.1 0.1

0.1

0.1

0.1

0.1 0.1

0.1

0.1

0.1 0.2

0.2

0.2 0.2

0.2

0.2

0.2 0.3 0.3

0.3 0.3

0.3 0.4 0.4

0.4 0.5

0.5 0.5 0.6 0.7 0.7

0.7

0.7 0.8 0.9 0.9 0.9 1.0

1.0 1.0 1.0 1.1 1.2 1.2

1.2 1.2 1.3

1.3

1.5

2.1 2.2

2.5

2.8

3.2

3.6

‐4.0

‐3.0

‐2.0

‐1.0

0.0

1.0

2.0

3.0

4.0

3UCR

FASLDIJQ

4EUEW

UO1D

HE1

SEF3EE

WDQ

WLH

KNZK

KPVX

XXL4

ZOIJZ

3OYX2R

3DA

LAM7

91AIRR

AAL7YF

ZH0THY

8YMBJO

2IQBJI

ZXIIII

NNNNDW

VQT273

U90

SWA

EAE6

LE77

DRQT

S9YJGM

6ILH

TLTR

QBQ

8P5

A5W5

OOOIM

OXQ

JTD9

SSOFTB

KTJBZA

UYPU5U

EXIP84

LFCJGM

RV3YT3

F9I31B

HNG20

UA1

O2P

UYEKYTF

SK10

2MFJ44

OK

6QO4X

58P

HIP8

BABK

JETD

VDNQ

YAIIV

OMOOSO

OQWO4O

F2M

O2K

2BP

J4JR

ZF1EFF

B54O

W4

J5YB

55LEPP

7LAS

UW2S

5XSW

BZAJO81

EAD

2NVY

BEUIGW

KYO33

2TIKK

KKZSX0

SSQUZQ

UQ

UFV

IOP

J288

55VX

FBR6

VYZC85

OOXO

OI

4LYN

GL

EDUYD

DIBPJLJ

MBO

MMM

QOMLQ

QYYZU

YYKH

HK0

GLN

R2DR

Z5LF55

CE7T

B2HW

0WRM

X70O

Z9VK

NEC

EQS88SU

TWTW

PH8IXV

437V

KRTZ

1GZV

LBDWWWGY

GCH

GCL

YY5Y1A

43D6

WO

3HKZSM

MQXQ

RQHCV

NSQ

ZFFEHN

YXZM

MX

GLYEEK

BAYYXO

00T0J0

OFP7ET

H7SE4O

EJBJCJ

R25T2B

RC98

IL4P

GIDD

6UM71

WEYAZ

VHSD

FWC8

OF6Y6

DTEZEE4

IXUGY

GKW

PD3V

LGEC

DNF1M4V

D6D

WSSS

G1C

7O1

9EWNN5

X2JIS

EWDN

NGN

P3Y0QX

ZRG6U

666

BMCC

5NU8Q

8VF

D46A

M9M

FMP

3QY6

YSKJU4O

UMCO

LDO

‐10.1

8.7

6.2

13.2

‐7.2

‐.4.6 ‐4.6

‐3.9

5.0

12.2

z-scores can be interpreted by participants in line with ISO 13528:2005, section 7.4.2 and ISO/IEC guide43-1:1997(E) as follows:

|z| < 2 = satisfactory 2 ≤ |z| ≤ 3 = questionable

|z| > 3 = unsatisfactory

According to the recommendations in ISO 13528:2005, an unsatisfactory z-score is considered to give an action signal and a questionable z-score is considered to give a warning signal. A single action signal or warning signals in two successive rounds shall be taken that an anomaly has occurred that requires investigation.

30

Round: 2016/1

Z-Score Report per Sample per Substance

-10

-8

-6

-4

-2

0

2

4

6

8

10z-

scor

e

Dispersion of z-scores using different analytical techniques for the quantification of cocaine in 2016/1 SM-1

HPLC GC-FID GC-MS/LC-MS

31


Code Identified Substances00T0J0 Ecstasy(MDMA)

1GZVLB MDMA

2IQBJI MDMA

2MO2K2 MDMA

2Q2RKB MDMA

331I33 3,4-Methylenedioxymetamfetamine (MDMA)

3HKZSM MDMA

3J30PJ MDMA

3QY6YS MDMA

3UCRFA MDMA

43D6WO MDMA

4EUEWU MDMA

4LYNGL 3,4-Methylenedioxymetamfetamine (MDMA), lactose

4PGIDD MDMA HCl

4Z40VI MDMA

55STC5 MDMA

5NU8Q8 MDMA

5XSWBZ MDMA

66BMCC MDMA

6AKET8 MDMA

6DWSSS MDMA hydrochloride

6ILHTL 3,4-Methylenedioxymethamphetamine (MDMA)

6QO4X5 MDMA hydrochloride

6UM71W MDMA

77DRQT 3,4-Methylenedioxymetamfetamine (MDMA)

7BTAAO Metamphatamine and Amphetamine

7VKRTZ MDMA

8F8I8T N-methyl-3,4-methylendioxyamphetamine

8IHHJF MDMA

8IXV43 MDMA

8LZBLR MDMA

8NM0BB MDMA and Lactose

8PHIP8 3,4-methylenedioxymethylamphetamine Hydrochloride (MDMA)

8YMBJO 3,4-Methylenedioxymetamfetamine (MDMA)

91AIRR MDMA

9EWNN5 MDMA

A1O2PU MDMA

AA3A9G MDMA

AAL7YF 3,4 Metylenedioxymethamfetamina (MDMA)

AD2NVY MDMA (3,4-METHYLENEDIOXYMETAMFETAMINE)

Sample 2 Analysis



32

Code Identified SubstancesAJO81E MDMA

ASUW2S 3,4-Methylenedioxymetamfetamine (MDMA)

AZCZ5Z MDMA

B54OW4 mdma

BABKJE Methylenedioxymethylamphetamine (MDMA)

BAYYXO MDMA

BEUIGW MDMA

BPJ4JR 3,4-Methylenedioxymetamfetamine hydrochoride

BT6Y0Y 3,4-Methylenedioxy-metamfetamine (MDMA)

C7G4DH MDMA

CE7TB2 MDMA (3,4-methylenedioxymethamphetamine)

CIFQC8 3,4-Methylenedioxymetamfetamine (MDMA)

CSJXFO MDMA

DALAM7 MDMA

DWWWGY MDMA

DY0EG9 MDMA

EAE6LE MDMA

EDUYDD MDMA

EJBJCJ MDMA

ELQNHU 3,4-Methylenedioxymethamfetamine (MDMA)

ENI7TJ 3,4-Methylendioxy-metamfetamine (MDMA)

EXIP84 MDMA

EYAWUL MDMA

EYAZVH 3,4-Methylenedioxymetamfetamine (MDMA)

F1M4VD MDMA

F9I31B MDMA hcl

FJ44OK MDMA

G1C7O1 MDMA

GCHGCL MDMA

GDGBEX MDMA

GLYEEK MDMA

H7SE4O MDMA

HCVNSQ MDMA

HNG20U MDMA

HW0WRM MDMA

IBPJLJ MDMA (Lactose also present)

ICQNLB 3,4 - methylenedioxymethamphetamine

IIX7UR 3,4-Metilenedioximetamfemine

ISA8Y8 3,4-Methylenedioxymetamfetamine (MDMA)

IUW8JU Methyl-3,4-methylenedioxyamphetamine

IXUGYG MDMA

J28855 MDMA

J5YB55 MDMA

JJLJOU 3,4-Methylenedioxymetamfetamine (MDMA)



33

Code Identified SubstancesKBC4MU MDMA

KHHK0G MDMA

KJU4OU MDMA,lactose

KLL25F MDMA (N-Methyl-3,4-Methylenedioxyamphetamine

KNZKKP MDMA

KTJBZA MDMA

KWPD3V MDMA

KYO332 MDMA

L9LTEO 3,4-Methylenedioxymetamfetamine (MDMA)

LEPP7L 3,4 Methylenedioxymetamfetamine (MDMA) and Lactose

LFCJGM MDMA

LGECDN MDMA

LLLLTB MDMA

LNR2DR MDMA

M5LL0L MDMA

M9MFMP 3,4 methylendioxymethylamphetamine

MBOMMM MDMA HCl

MOOSOO MDMA

MQXQRQ MDMA

MVVNXZ MDMA

NNNNDW MDMA

O1DHE1 MDMA

O28H4R MDMA

OF6Y6D MDMA

OFP7ET MDMA

OOOIMO MDMA (3,4-metylendioximethamfetamine)

OOXOOI MDMA

OSTFUT MDMA

OWRO6K MDMA

OYX2R3 N-metil-3-4-metillendioxianfetamina (MDMA)

OZLPCC MDMA,Synthetic cathinones

P3Y0QX MDMA

P5A5W5 MDMA

P7ZPBP Yes MDMA

PPPKPP MDMA

QOMLQQ MDMA

QS88SU MDMA

QUZQUQ MDMA

QWO4OF MDMA

R25T2B MDEA

R2XKWH MDMA

R3QRYO MDMA

RC98IL MDMA HCL

RV3YT3 MDMA



34

Code Identified SubstancesS9YJGM MDMA

SDFWC8 MDMA HCl

SEF3EE 3,4-methylenedioxy-metamfetamine (MDMA)

SK102M MDMA

SLDIJQ MDMA

SSOFTB 3,4-Methylenedioxymetamfetamine (MDMA)

T7YTFO 3,4-methylenedioxy-metamfetamine (MDMA)

TBK0V2 MDMA

TDVDNQ MDMA

TEZEE4 MDMA, LACTOSE

TIKKKK MDMA

TRQBQ8 MDMA HCL

TSGAGB 3, 4 - METHYLENEDIOXY-METAMFETAMINE(MDMA)

TWTWPH MDMA

TWYAAL MDMA

U90SWA MDMA

UFVIOP MDMA

UQMBX2 MDMA

UYPU5U MDMA HCL

VFD46A MDMA

VKNECE MDMA 14.08

VNZ61V 3,4-Methylenedioxymetamfetamine

VQT273 MDMA

VXFBR6 3,4-Methylenedioxymetamfetamine (MDMA)

VXXXL4 3,4-MDMA

VYZC85 MDMA

WDNNGN MDMA

WDQWLH MDMA

X2JISE MDMA

X456G5 MDMA, LACTOSE

X70OZ9 MDMA

XFVW1V MDMA

XNQ60K MDMA

XQJTD9 MDMA

XRKU5U MDMA

Y38I3T MDMA

YAH8BE MDMA

YAIIVO 3,4-Methylenedioxymethamphetamine Hydrochloride

YEKYTF MDMA

YXZMMX MDMA

YY5Y1A MDMA

YY7MQP MDMA, lactose

YYZUYY MDMA

Z5LF55 MDMA



35

Code Identified SubstancesZ887DL MDMA

ZF1EFF MDMA

ZFFEHN MDMA 13.9%

ZH0THY MDMA

ZOIJZ3 MDMA

ZRG6U6 MDMA

ZSX0SS MDMA

ZXIIII MDMA



36

Code 3,4-Methylenedioxymetamfetamine (MDMA)

Lactose

00T0J0 + +Sample contained MDMA cut with Lactose

1GZVLB + ANP

2IQBJI + ANPfound MDMA with 14.3%w/w

2MO2K2 + +./.

2Q2RKB + -MDMA Confirmed

331I33 + ANP

3HKZSM + +Mixture of MDMA in lactose. Content of lactose is approx.70 % w/w.

3J30PJ + ANP

3QY6YS + ANP

3UCRFA + +the sample contains a mixture of MDMA and lactose

43D6WO + ANPMDMA is the common name for methylenedioxymethyl amphetamine. It is a Class A controlled drug subject to the provisions of the Misuse of Drugs Act 1971 as it is structurally derived from an N-alkyl-alpha methylphenethylamine by substitution in the ring with an alkylenedioxy substituent.

4EUEWU + -The sample 2016/1/SM-2 was found to contain the illicit drug MDMA.

4LYNGL + +The 3,4-Methylenedioxymetamfetamine (MDMA) is scheduled as illicit drug in XXXX. The lactose is a cutting agent.

4PGIDD + +The sample contains MDMA and lactose.MDMA is sheduled as illicit drug.

4Z40VI + +MDMA, lactose-GCMS-compare mass spectra with library, retention time of sreference sample and MDMA, FTIR-lactose

55STC5 + ANP

5NU8Q8 + +The powder was analysed and found to contain methylenedioxymethylamphetamine (MDMA) and lactose.

5XSWBZ + +MDMA and lactose

66BMCC + -found MDMA with 18.23% w/w in SM-2

6AKET8 + ANPSM-1 found to contain MDMA

Statement of findings for Test Sample 2



37


Lactose

6DWSSS + +white powder containing MDMA and lactose as diluent

6ILHTL + +The sample contained 13.71% w/w MDMA (base).Substance detected include lactose.

6QO4X5 + +MDMA base 13,5 %

6UM71W + +MDMA is controlled by KB 22/01/1998

77DRQT + +3,4-Methylenedioxymetamfetamine (MDMA) Hydrochloride 14.7% as base - LACTOSE

7BTAAO ANP ANPThere was evidence of Metamphetamine and Amphetamine in sample 2

7VKRTZ + +This sample contains MDMA

8F8I8T + +Lactose

8IHHJF + ANP

8IXV43 + -A sample of this powder was analysed and found to contain MDMA at a concentration of 16%.

8LZBLR + +SM-2 to contain MDMA

8NM0BB + +The Test sample 2016/1/SM-2 was analyzed by Colour test and Thin Layer Chromatography technique and found to contain MDMA and Lactose.

8PHIP8 + +A sealed glass vial containing a white powder. This powder contained an average of 16% 3,4-methylenedioxymethylamphetamine Hydrochloride (MDMA)

8YMBJO + ANPThe sample consist controlled drugs - 3,4-Methylenedioxymetamfetamine (MDMA)

91AIRR + ANP

9EWNN5 + -The item is a powder containing MDMA hydrocloride , the percent of free base of MDMA is 16.3%

A1O2PU + ANPwhite powder without any smell

AA3A9G + ANPWhite powder containing MDMA.

AAL7YF + +Marquis Reagent: black; Simon´s: blueGC/MS: RT 10,91 min / Mass Spectrum principal peaks at m/Z 58, 135, 77, 51, 55

AD2NVY + ANP

AJO81E + +

ASUW2S + +Also contain lactose



38


Lactose

AZCZ5Z + ANPMDMA

B54OW4 + ANPwhite powder containing MDMA (14,4%w/w)

BABKJE + ANPThe powder, which weighed 0.22 grams, was analysed and found to contain Methylenedioxymethylamphetamine (MDMA).Methylenedioxymethylamphetamine (MDMA) is a compound structurally derived from an N-alkyl-alpha-methylphenethylamine by substitution in the ring with an alkylenedioxy substituent, and as such is a class A controlled drug within the provisions of the Misuse of Drugs Act 1971.

BAYYXO + +Sample contains MDMA hydrochloride and lactose.

BEUIGW + +La muestra contiene MDMA.

BPJ4JR + +It has been detected the presence of 3,4-Methylenedioxymetamfetamine hydrochoride in the sample

BT6Y0Y + +Sample 2016/1/SM-2 consists of white powder. 3,4-Methylenedioxy-metamfetamine (MDMA), a prohibited substance included in the National Law forNarcotics, is found to be present in this sample.

C7G4DH + +lactose

CE7TB2 + +The sample contains MDMA (3,4-methylenedioxymethamphetamine). The content of MDMA(as hydrochloride) is determined to 16 %. MDMA is a controlled substance in X.

CIFQC8 + ANPSample 2016/1/SM-2, an off-white odourless powder, gave a positive result for 3,4-methylenedioxymetamfetamine (MDMA), a controlled substance under national legislation on drugs.

CSJXFO + ANPExamination revealed the presence of N methyl-3,4 methylenedioxyamphetamine (MDMA)

DALAM7 + +The sample 2 contains MDMA chlorhydrate at 14% per weight (12% base), which is a controlled substance in XXXXX.

DWWWGY + +MDMA, LACTOSA

DY0EG9 + -the results of the screening test "TLC (Tech:150)" and identification , confirmation analytic techniques HPLC (160) and GC/MS (180).

E8S7ZT ANP ANPnous avions en screening des substances sous contrôle (Méthamphétamine, opium, safrole ou isosafrole) mais l'identification et la confirmation n'ayant pas pu être faute de standards, nous ne pouvons pas les mentionner. A la limite des techniques utilisées et le manque de standards nous n'avons pas pu identifier de substances sous contrôle.

EAE6LE + ANPThe sample contains MDMA. The content of MDMA as base is 15.6%.

EDUYDD + +The sample contains MDMA which is listed as a controlled drug according to XXXX order, appendix III of February 22nd 1990.



39


Lactose

EJBJCJ + ANPIn the test sample 2016/1/SM-2 was detected MDMA

ELQNHU + +Based on the above analysis, the sample was found to contain 3,4-Methylenedioxymetamfetamine (MDMA) and lactose.

ENI7TJ + ANPFrom screening test using (MR), (FTIR) and ion scan and from confirmatory test using (GC-MS), the sample was found to contain controlled drug MDMA.

EXIP84 + +Sample also contain lactose. The presence of drug confirmed by GC-MS and FTIR spectroscopy analysis.The hydrochloride form of MDMA was confirmed by the anion analysis and FTIR spectroscopy.

EYAWUL + +SM2 contains MDMA and Lactose.

EYAZVH + ANPThe sample contains a controlled substance as MDMA and caffeine cutting.

F1M4VD + +MDMA was identified by GC-MS.

F9I31B + +MDMA and Lactose. BASE MDMA 13,33 +/- 1,49% (w/w)

FJ44OK + -

G1C7O1 + +Lactose

GCHGCL + +Sample contains 12.43 ± 0.68 % MDMA base. Lactose was also detected.

GDGBEX + ANPSample SM-2 was found to contain MDMA.

GLYEEK + ANPThe sample 2016/1/SM-2 contains MDMA and lactose

H7SE4O + -

HCVNSQ + +MDMA, lactose

HNG20U + +Was found lactose

HW0WRM + ANP

IBPJLJ + +The powder contained 3,4-Methylenedioxymethamphetamine (MDMA), together with the adulterant lactose

ICQNLB + ANPPowder from test sample 2016/1/SM-2 contain 3,4- methylenedioxymethamphetamine (MDMA)

IIX7UR + ANPMarquis reagent (MR) positive. GC/MS Retention time and mass charge ratio (M/Z), similar characteristics whit the subtances used as standar or pattern.

ISA8Y8 + ANPSample 2016/1/SM-2 found to contain 3,4Methylenedioxymetamfetamine (MDMA)



40


Lactose

IUW8JU + ANPDe los análisis realizados, se concluye que la sustancia se trata de Metil-3,4-metilendioxianfetamina (MDMA)

IXUGYG + ANP-

J28855 + +MDMA AND LACTOSE

J5YB55 + +MDMA and lactose as a diluent

JJLJOU + ANPin the sample labeled as 2016/1 / SM-2 3,4-Methylenedioxymetamfetamine (MDMA) was found.

KBC4MU + ANPWhite powder that contains controlled substance MDMA.

KHHK0G + +The sample was found to contain 13.5% of MDMA (as base). The sample was also found to contain lactose.

KJU4OU + +Black colour appear with Marquis Test.Blue colour with Simon test indicates the possable presence of MDMA.Analysis of GCMS shows the similarity as MDMA and lactose.

KLL25F + ANP- From colorimetric reaction it gave black color with Marquis Reagent and blue color with Simon Reagent- From GCMS analysis, MDMA was detected

KNZKKP + +

KTJBZA + +The test sample also contained lactose

KWPD3V + ANPMDMA was detected by GC/MS screening and it was quantified by GC/FID

KYO332 + +It is an usually detected drug in our laboratory.

L9LTEO + +Test sample 2016/1/SM-2 contains MDMA, a dangerous drug. It also contains Lactose.

LEPP7L + +

LFCJGM + -

LGECDN + -The sample contains MDMA (13,6%).

LLLLTB + -The test sample SM-2 contains stimulating narcotic drugs MDMA.

LNR2DR + +Lactose

M5LL0L + ANP



41


Lactose

M9MFMP + ANPscreening by colorimetric testconfirmation by GC-MS quantification by GC-MS

MBOMMM + +lactose

MCOLDO ANP ANP

MOOSOO + +Test sample 2016/1/SM-2 contains MDMA 14.8 %, m/m and lactose.

MQXQRQ + +In Sample 2 was identified MDMA and lactose.

MVVNXZ + ANPThe white powder contains MDMA (3,4-Methylene-dioxyamphetamine.

NNNNDW + ANPIt contains 13.43% of MDMA

O1DHE1 + ANPConfirmed by gc ms

O28H4R + -GC-MS

OF6Y6D + +

OFP7ET + +lactose

OOOIMO + ANPMDMA, conc. 14% as free base

OOXOOI + +MDMA

OSTFUT + +lactose

OWRO6K + -MDMA was analysed.

OYX2R3 + +CONTIENE ADEMÁS LACTOSA MONOHIDRATADA, FUE IDENTIFICADA POR FTIR, Y CON EL RAMAN TRUNARC SE IDENTIFICO MDMA, CONFIRMADO CON GC/MS, NO SE CUANTIFICÓ POR NO CONTAR CON ESTANDAR CERTIFICADO.

OZLPCC + ANPSynthetic cathinones have not been determine for the lak of reagents

P3Y0QX + ANPwhite powder containing 14,0%w/w of MDMA

P5A5W5 + -Presence of MDMA, concentration of 13.50%, without adulterants.

P7ZPBP + ANPA preliminary test SCOTT and MARQUIS to know what kind of drugs were present in the samples that have been sent and two confirmation tests TLC and GC-FID. In the case of the sample referenced with the code 2016/1/SM-2 was able to verify the presence of MDMA Marquis test.



42


Lactose

PPPKPP + ANPPowder was analysed and found to contain 3,4-methylenedioxymethamphetamine.

QOMLQQ + ANP

QS88SU + +The sample contianed 14.1 % MDMA and lactose.

QUZQUQ + +Mass spectrometry profile correlation between sample and reference material certified

QWO4OF + -

R25T2B - -We diluited 1 mg of the sample in 10 mL of methanol and analized by CG-MS.

R2XKWH + -

R3QRYO + ANPNil

RC98IL + +SM2 was prepared from a seizure containing 15% w/w MDMA base. The sample also contained lactose

RV3YT3 + ANPPowder containing MDMA

S9YJGM + -The results of the test of SM2 (46) received confirmed that the mentioned simple contains MDMA but we are not able to give a cuantification result.

SDFWC8 + +additional substance: lactose

SEF3EE + +MDMA and lactose were identified in the sample.Analysis revealed that percentage of MDMA is 4.40%.

SK102M + ANP

SLDIJQ + +the sample is mixutre od MDMA and lactose

SSOFTB + +Presence of MDMA: retention time and MS spectra in GC analysis (FID and MS). MDMA as hydrochloride.Presence of lactose: FTIR and XRD analysis.

T7YTFO + +

TBK0V2 + ANPSUSTANCIA DISUELTA EN METANOL E IDENTIFICADA MEDIANTE CG/FID Y UV

TDVDNQ + ANPx grams of powder containing 13% MDMA (methylenedioxymethylamphetamine)

TEZEE4 + +We determined a mixture of MDMA and Lactose.

THQ2CH + -



43


Lactose

TIKKKK + ANPSM-2 contains MDMA

TRQBQ8 + +LACTOSE

TSGAGB + ANPThe 2016/1/SM1-2 was found to contain 3,4-Methylenedioxymetamfetamine (MDMA).

TWTWPH + ANP

TWYAAL + +The sample contains MDMA and lactose

U90SWA + +Quantification HPLC : 14.4 %

UFVIOP + +The sample contains MDMA and lactose.

UQMBX2 + +WHITE POWDER SAMPLE ANALYZED CONTAINS MDMA

UYPU5U + +229 milligrams of a white powder containing 3,4-methylenedioxymethylamphetamine hydrochloride and lactose. This white powder contained an average of 13% of 3,4-methylenedioxymethylamphetamine (purity has been calculated in the base form).

VFD46A + -the SM-2 sample contains 15.41% of MDMA

VKNECE + -After analyzing the sample with CR, MSD confirmation and FID quantification we can confirm that sample contains MDMA.

VNZ61V + ANPTHE SAMPLE CORRESPOND IS 3,4-Methylenedioxymetamfetamine (MDMA)

VQT273 + +lactose

VXFBR6 + ANP3,4-Methylenedioxymetamfetamine (MDMA) - 12.45%

VXXXL4 + ANPthe white powder contains MDMA (19.5%) which is controlled by national law.

VYZC85 + +MDMA is on the list of drugs

WDNNGN + +after chemical analysis was performed the sample was found to contain1/ MDMA 0.22 %2/Lactose

WDQWLH + ANPPowder containing MDMA

X2JISE + ANP

X456G5 + +

X70OZ9 + ANP



44


Lactose

XFVW1V + +In this Sample Contain tow substance MDMA and Lactose

XNQ60K + ANP

XQJTD9 + +Cocaine existed in baseform. We found lactose in the sample

XRKU5U + +On analysis, I found the sample "SM-2" containing MDMA and Lactose.

Y38I3T + ANPEn la muestra SM-2, se encontro la presencia de MDMA

YAH8BE + +lactose

YAIIVO + +3,4-Methylenedioxymethamphetamine hydrochloride and lactose were confirmed in 1 unit tested of 1 unit received.

YEKYTF + +powder contains MDMA and lactose

YXZMMX + ANPMDMA is a controlled drug.

YY5Y1A + ANPResults of screening tests were positive for secondary amfetamines. Retention time and fragmentation pattern obtained with sample are equivalent to those obtained with MDMA.

YY7MQP + +

YYZUYY + -The sample contains 14,25 % 3,4-Methylendioxymethamphetamine (as free base)

Z5LF55 + +the powder is a mixture of MDMA hydrochloride and lactose hydrate. The concentration of MDMA (base) in the sample is 13.1% by weight.

Z887DL + -The test sample 2016/1/SM-2 was found to contain the controlled drug 3,4-Methylenedioxy-metamfetamine (MDMA).

ZF1EFF + +Presence of 3,4-Methylenedioxymetamfetamine hydrochloride and lactose was detected in the sample.

ZFFEHN + -

ZH0THY + -

ZOIJZ3 + ANP

ZRG6U6 + ANPAnalysis of a representative sample of the powder revealed the presence of methylenedioxymethylamphetamine (MDMA) with a purity of approximately 13% (calculated as base).

ZSX0SS + ANPOne glass bottle containing 0.23 grammes of a powder containing 0.03 grammes of 3,4-methylenedioxy-methamphetamine.



45


Lactose

ZXIIII + +MDMA and Lactose



46

Identification methods for Test Sample 2

Code 140 141 142 150 160 161 171 180 190 200 211 220 230 231 210

00T0J0 S I I I I

1GZVLB SI SI SI I

2IQBJI SI

2MO2K2 I SI SI

2Q2RKB S S S I I

331I33 SI

3HKZSM I I S Raman

3J30PJ S SI I I I

3QY6YS I SI

3UCRFA S S S I I

43D6WO S S I

4EUEWU S I

4LYNGL S I I

4PGIDD I SI

4Z40VI S S SI I

55STC5 SI

5NU8Q8 S I I

5XSWBZ I SI

66BMCC I S I

6AKET8 S S I

6DWSSS SI I

6ILHTL S S S I I

6QO4X5 S I I

6UM71W I SI

77DRQT S S S I I

7BTAAO SI I

7VKRTZ S I I

8F8I8T S S I S

8IHHJF S S I I

8IXV43 SI SI I I I I

8LZBLR S S S SI I

8NM0BB S S SI S Fast Blue B Salt test

8PHIP8 S S I I

8YMBJO I SI

Analytical Technique Codes

Legend: S ... used for Screening I ... used for Identification SI ... used for both



47

Code 140 141 142 150 160 161 171 180 190 200 211 220 230 231 210

91AIRR I SI

9EWNN5 I

A1O2PU SI

AA3A9G S SI SI SI

AAL7YF S S S I I

AD2NVY I SI

AJO81E SI I HPLC-RID

ASUW2S S I I

AZCZ5Z SI I

B54OW4 I SI

BABKJE S I

BAYYXO S S S SI I I S microscopic and macroscopic examination

BEUIGW S S S I I

BPJ4JR I S I

BT6Y0Y S S I I

C7G4DH S SI SI I

CE7TB2 I I

CIFQC8 S S S I

CSJXFO SI

DALAM7 SI

DWWWGY

S S S I I

DY0EG9 S I I S

E8S7ZT S S I

EAE6LE S S S SI I

EDUYDD I I

EJBJCJ I

ELQNHU S I I

ENI7TJ S S I I S Negm's test

EXIP84 S I I

EYAWUL S I

EYAZVH S I SI

F1M4VD S S S I I

F9I31B S S S I I I RDX

FJ44OK SI

G1C7O1 S I I I

GCHGCL S I SI I

GDGBEX S I I

GLYEEK S S S I S tanred



48

Code 140 141 142 150 160 161 171 180 190 200 211 220 230 231 210

H7SE4O I I SI

HCVNSQ SI SI SI SI I SI I

HNG20U S S I I

HW0WRM

S S S I

IBPJLJ S S S I I

ICQNLB S S I I

IIX7UR S S S I

ISA8Y8 S I

IUW8JU S SI SI macroscopic analysis

IXUGYG SI

J28855 S I I

J5YB55 I SI I

JJLJOU I I SI

KBC4MU S S SI I I S Simon

KHHK0G SI I LC/ELSD

KJU4OU S I

KLL25F S I

KNZKKP SI

KTJBZA I I

KWPD3V SI

KYO332 S I I I Fehling Reagent

L9LTEO S S S I I I Duquenois-Levine reagent

LEPP7L S S S I I

LFCJGM SI

LGECDN S S S I I

LLLLTB I SI S I SI

LNR2DR SI SI

M5LL0L I

M9MFMP S S I I

MBOMMM

SI

MCOLDO I I S not stated

MOOSOO I SI

MQXQRQ I I

MVVNXZ S S S I I

NNNNDW SI I

O1DHE1 I I SI

O28H4R SI

OF6Y6D I SI



49

Code 140 141 142 150 160 161 171 180 190 200 211 220 230 231 210

OFP7ET S S S I I

OOOIMO SI

OOXOOI S S S I I

OSTFUT S SI SI I

OWRO6K S I I

OYX2R3 S S I I S RAMAN

OZLPCC SI I S SI Rapid Test

P3Y0QX I SI

P5A5W5 I I

P7ZPBP S S S I I

PPPKPP S S S I I

QOMLQQ S S S I

QS88SU I I SI I

QUZQUQ I I

QWO4OF SI S S I

R25T2B SI

R2XKWH I S

R3QRYO S I

RC98IL I I

RV3YT3 SI

S9YJGM S S S I I

SDFWC8 SI I

SEF3EE S S I I I S fast blue B salt test

SK102M S S I S microscopy

SLDIJQ SI I I I I

SSOFTB I I SI I XRD

T7YTFO S I I

TBK0V2 I I S

TDVDNQ S S I I

TEZEE4 SI S S SI I I I

THQ2CH S S S SI I I I I

TIKKKK S S S I I S

TRQBQ8 SI

TSGAGB I SI

TWTWPH I S

TWYAAL S S I I SI

U90SWA SI I

UFVIOP SI I

UQMBX2 S S S I I



50

Code 140 141 142 150 160 161 171 180 190 200 211 220 230 231 210

UYPU5U S S I I I Ehrlich

VFD46A S I I I I HPLC/RID

VKNECE SI I

VNZ61V I SI

VQT273 S I

VXFBR6 I SI

VXXXL4 I SI

VYZC85 I I S I

WDNNGN SI

WDQWLH S S S I

X2JISE I

X456G5 SI

X70OZ9 I

XFVW1V S I I

XNQ60K SI I

XQJTD9 S I I

XRKU5U S I I

Y38I3T SI SI SI

YAH8BE I SI SI

YAIIVO SI I I

YEKYTF SI I

YXZMMX I I

YY5Y1A S S S I

YY7MQP S S S I I

YYZUYY SI

Z5LF55 I I I SI I xrd

Z887DL S S S I I

ZF1EFF S I I I I

ZFFEHN S S S SI I SI

ZH0THY S S S I

ZOIJZ3 S S SI

ZRG6U6 S S S I I

ZSX0SS S S SI

ZXIIII S I



51



Frequency of use of screening and identification techniques:

Summary for test sample 2The response summary of all 183 participating laboratories for the identification of SM-2, frequency of use of screening andidentification techniques and false positives and negatives:

Identification of test sample 2:

False positives for Test Sample 2

Code Name Technique XQJTD9 cocaine 171/180


False negatives for SM-2 (techinque(s) used or ANP)

Code: R25T2B (180), 7BTAAO (140/200) (MCOLDO (ANP), E8S7ZT (ANP)

142 150 160 161 190 200 220160Response Summary Participants: 176

76BTAAO metamfetamine, amfetamine 140/200

R25T2B MDEA 180

Section 142 150 160 161 171 180 190 200 211 230 231


Response SummaryParticipants: 183

3,4-Methylenedioxymetamfetamine (MDMA):

179

Section 140 141 142 150 160 161 171 180 190 200 211 220 230 231 210

Screening 66 73 60 22 0 1 4 61 17 2 0 1 0 0 11

36.3% 40.1% 33.0% 12.1% 0.0% 0.5% 2.2% 33.5% 9.3% 1.1% 0.0% 0.5% 0.0% 0.0% 6.0%

Identification 14 6 4 36 8 15 29 165 72 4 3 0 5 1 12

7.7% 3.3% 2.2% 19.8% 4.4% 8.2% 15.9% 90.7% 39.6% 2.2% 1.6% 0.0% 2.7% 0.5% 6.6%

# labs using this technique

71 75 61 45 8 15 30 165 79 6 3 1 5 1 2139.0% 41.2% 33.5% 24.7% 4.4% 8.2% 16.5% 90.7% 43.4% 3.3% 1.6% 0.5% 2.7% 0.5% 11.5%


52





averagez-score


Deviation from

robust average

z-score

WDNNGN 0.2 -13.6 -11.1 SSOFTB 13.6 -0.2 -0.2SEF3EE 4.4 -9.4 -7.7 ZF1EFF 13.7 -0.1 -0.1A1O2PU 8.7 -5.1 -4.2 7VKRTZ 13.7 -0.1 -0.1KNZKKP 10.2 -3.6 -3.0 6ILHTL 13.7 -0.1 -0.1KJU4OU 10.2 -3.6 -2.9 UFVIOP 13.7 -0.1 -0.1

TWTWPH 10.6 -3.2 -2.6 MQXQRQ 13.8 0.0 0.0WDQWLH 11.4 -2.4 -2.0 H7SE4O 13.8 0.0 0.0G1C7O1 11.5 -2.3 -1.9 EDUYDD 13.8 0.0 0.0EXIP84 11.9 -1.9 -1.6 ZFFEHN 13.9 0.1 0.1LNR2DR 12.0 -1.8 -1.5 RV3YT3 13.9 0.1 0.1DALAM7 12.0 -1.8 -1.5 P3Y0QX 14.0 0.2 0.1BPJ4JR 12.3 -1.5 -1.2 HCVNSQ 14.0 0.2 0.1X70OZ9 12.4 -1.4 -1.2 8PHIP8 14.0 0.2 0.1GCHGCL 12.4 -1.4 -1.2 SLDIJQ 14.0 0.2 0.2VXFBR6 12.5 -1.4 -1.1 VYZC85 14.1 0.3 0.2AD2NVY 12.5 -1.3 -1.1 VKNECE 14.1 0.3 0.2YEKYTF 12.7 -1.1 -0.9 6DWSSS 14.1 0.3 0.2OOXOOI 12.7 -1.1 -0.9 QS88SU 14.1 0.3 0.2

HW0WRM 12.8 -1.0 -0.8 KTJBZA 14.2 0.4 0.3SDFWC8 12.8 -1.0 -0.8 BEUIGW 14.2 0.4 0.3VQT273 12.9 -0.9 -0.8 OFP7ET 14.2 0.4 0.3R2XKWH 12.9 -0.9 -0.7 YYZUYY 14.3 0.4 0.4F1M4VD 12.9 -0.9 -0.7 2IQBJI 14.3 0.5 0.44EUEWU 13.0 -0.8 -0.7 4PGIDD 14.3 0.5 0.4YAIIVO 13.0 -0.8 -0.7 ZOIJZ3 14.3 0.5 0.4ZRG6U6 13.0 -0.8 -0.7 6UM71W 14.3 0.5 0.4IBPJLJ 13.0 -0.8 -0.7 ZSX0SS 14.3 0.5 0.4

UYPU5U 13.0 -0.8 -0.7 B54OW4 14.4 0.6 0.5TDVDNQ 13.0 -0.8 -0.7 U90SWA 14.4 0.6 0.5Z5LF55 13.1 -0.7 -0.6 MBOMMM 14.4 0.6 0.5EJBJCJ 13.2 -0.6 -0.5 KYO332 14.4 0.6 0.5

QUZQUQ 13.2 -0.6 -0.5 AJO81E 14.4 0.6 0.5TIKKKK 13.3 -0.5 -0.4 3QY6YS 14.5 0.7 0.6X2JISE 13.3 -0.5 -0.4 77DRQT 14.7 0.9 0.7F9I31B 13.3 -0.5 -0.4 J5YB55 14.7 0.9 0.7FJ44OK 13.4 -0.4 -0.3 331I33 14.8 1.0 0.8CE7TB2 13.4 -0.4 -0.3 8YMBJO 14.8 1.0 0.8XQJTD9 13.4 -0.4 -0.3 MOOSOO 14.8 1.0 0.85XSWBZ 13.4 -0.4 -0.3 ZXIIII 14.9 1.1 0.92MO2K2 13.4 -0.4 -0.3 4LYNGL 15.0 1.2 1.0NNNNDW 13.4 -0.4 -0.3 RC98IL 15.0 1.2 1.0P5A5W5 13.5 -0.3 -0.3 91AIRR 15.0 1.2 1.03HKZSM 13.5 -0.3 -0.3 LFCJGM 15.2 1.4 1.1KHHK0G 13.5 -0.3 -0.3 OF6Y6D 15.2 1.4 1.16QO4X5 13.5 -0.3 -0.2 ISA8Y8 15.2 1.4 1.1SK102M 13.6 -0.2 -0.2 VFD46A 15.4 1.6 1.3LGECDN 13.6 -0.2 -0.2 KWPD3V 15.5 1.7 1.4OOOIMO 13.6 -0.2 -0.2 EAE6LE 15.6 1.8 1.5

Code

MDMA

Code

MDMA

53




Deviation from

robust average

z-score

8IXV43 15.6 1.8 1.5EYAZVH 16.0 2.2 1.8IXUGYG 16.0 2.2 1.8QOMLQQ 16.2 2.4 1.9QWO4OF 16.2 2.4 2.09EWNN5 16.3 2.5 2.0BAYYXO 16.5 2.7 2.200T0J0 17.3 3.5 2.866BMCC 18.2 4.4 3.6VXXXL4 19.5 5.7 4.7

DWWWGY 32.0 18.2 14.9

MDMA

Code

54

Substance: SM-2; MDMA

Round: 2016/1


Robust average = 13.8%UNODC value = 13.8%

z-scores can be interpreted by participants in line with ISO 13528:2005, section 7.4.2 and ISO/IEC guide43-1:1997(E) as follows:

|z| < 2 = satisfactory 2 ≤ |z| ≤ 3 = questionable

|z| > 3 = unsatisfactory

According to the recommendations in ISO 13528:2005, an unsatisfactory z-score is considered to give an action signal and a questionable z-score is considered to give a warning signal. A single action signal or warning signals in two successive rounds shall be taken that an anomaly has occurred that requires investigation.

‐3.0 ‐2.9

‐2.6

‐2.0 ‐1.9

‐1.6 ‐1.5

‐1.5

‐1.2 ‐1.2

‐1.2 ‐1.1 ‐1.1 ‐0.9

‐0.9 ‐0.8

‐0.8 ‐0.8 ‐0.7

‐0.7 ‐0.7

‐0.7

‐0.7

‐0.7

‐0.7

‐0.7 ‐0.6 ‐0.5 ‐0.5 ‐0.4

‐0.4 ‐0.4 ‐0.3

‐0.3

‐0.3

‐0.3

‐0.3 ‐0.3 ‐0.3

‐0.3

‐0.3

‐0.2 ‐0.2

‐0.2

‐0.2

‐0.2 ‐0.1

‐0.1

‐0.1 ‐0.1 0.0

0.0

0.0

0.1

0.1 0.1

0.1

0.1 0.2 0.2

0.2

0.2

0.2 0.3

0.3 0.3 0.4 0.4

0.4

0.4

0.4

0.4 0.5

0.5

0.5

0.5

0.5 0.6 0

.7 0.7 0.8

0.8

0.8 0.9 1.0

1.0 1.0 1.1 1.1

1.1 1

.3 1.4 1.5

1.5

1.8

1.8 1.9 2.0 2.0 2.2

2.8

3.6

‐4.0

‐3.0

‐2.0

‐1.0

0.0

1.0

2.0

3.0

4.0

WDN

NGN

SEF3EE

A1O2P

UKN

ZKKP

KJU4O

UTW

TWPH

WDQ

WLH

G1C

7O1

EXIP84

LNR2

DRDA

LAM7

BPJ4JR

X70O

Z9GCH

GCL

VXFBR6

AD2N

VYYEKYTF

OOXO

OI

HW0W

RMSD

FWC8

VQT273

R2XK

WH

F1M4V

D4EUEW

UYA

IIVO

ZRG6

U6

IBPJLJ

UYPU5U

TDVD

NQ

Z5LF55

EJBJCJ

QUZQ

UQ

TIKK

KKX2

JISE

F9I31B

FJ44

OK

CE7TB2

XQJTD9

5XSW

BZ2M

O2K

2NNNNDW

P5A5

W5

3HKZSM

KHHK

0G6Q

O4X

5SK10

2MLG

ECDN

OOOIM

OSSOFTB

ZF1EFF

7VKR

TZ6ILH

TLUFV

IOP

MQXQ

RQH7

SE4O

EDUYD

DZFFEHN

RV3YT3

P3Y0QX

HCVN

SQ8P

HIP8

SLDIJQ

VYZC85

VKNEC

E6D

WSSS

QS88SU

KTJBZA

BEUIGW

OFP7ET

YYZU

YY2IQBJI

4PGIDD

ZOIJZ

36U

M71W

ZSX0

SSB5

4OW4

U90

SWA

MBO

MMM

KYO332

AJO81

E3Q

Y6YS

77DR

QT

J5YB

5533

1I33

8YMBJO

MOOSO

OZXIIII

4LYN

GLRC

98IL

91AIRR

LFCJGM

OF6Y6D

ISA8

Y8VF

D46A

KWPD

3VEA

E6LE

8IXV

43EYAZ

VHIXUG

YGQOMLQ

QQWO4O

F9EWNN5

B AYYXO

00T0J0

66BM

CCVX

XXL4

DWWWGY

‐11.1

‐7.7

‐4.2

4.7

14.9

55

Round: 2016/1


-10

-8

-6

-4

-2

0

2

4

6

8

10z-

scor

e

Dispersion of z-scores using different analytical techniques for the quantification of MDMA in 2016/1 SM-2

HPLC GC-FID GC-MS/LC-MS

56


Code Identified Substances00T0J0 Amphetamine

1GZVLB anfetamina

2MO2K2 AMFETAMINE

2Q2RKB Amfetamine

331I33 Amfetamine

3HKZSM Amfetamine

3J30PJ Cafeina

3QY6YS amfetamine

3UCRFA Amfetamine

43D6WO Amphetamine, purity 5.4%

4EUEWU AMPHETAMINE

4LYNGL amfetamine, caffeine

4PGIDD amphétamine

4Z40VI Amfetamine

55STC5 Amphetamine

5NU8Q8 Amfetamine

5XSWBZ amphetamine

66BMCC AMFETAMINE

6AKET8 Amphetamine

6DWSSS amphetamine sulphate

6ILHTL Amphetamine

6QO4X5 amphethamine sulphate

6UM71W amphetamine

77DRQT Amfetamine

7BTAAO Metamphetamine and Amphetamine

7VKRTZ Amphetamine

8F8I8T Amphetamine

8IHHJF ANFETAMINA

8IXV43 Amphetamine

8LZBLR Amfetamine

8NM0BB Amfetamine and Caffeine

8PHIP8 Amphetamine

8YMBJO Amphetamine

91AIRR Amphetamine

9EWNN5 Amphetamine

A1O2PU ---

AA3A9G Amphetamine

AAL7YF Amfetamine

AD2NVY AMFETAMINE

AJO81E amphetamine

Sample 3 Analysis



57

Code Identified SubstancesASUW2S Amfetamine

AZCZ5Z Amphetamine

B54OW4 ---

BABKJE Amphetamine

BAYYXO amphetamine

BEUIGW Anfetamina

BPJ4JR amfetamine

BT6Y0Y Amfetamine

C7G4DH amphetamine

CE7TB2 Amphetamine

CIFQC8 Amfetamine

CSJXFO Amphetamine

DALAM7 AMFETAMINE

DWWWGY ANFETAMINA

DY0EG9 AMPHETAMINE

EAE6LE Amphetamine

EDUYDD Amfetamine

EJBJCJ Amfetamine

ELQNHU Amphetamine

ENI7TJ Amphetamine

EYAWUL Amfetamine

EYAZVH Amfetamine

F1M4VD Amphetamine

F9I31B Amphetamine sulphate

G1C7O1 Amfetamine

GCHGCL Amfetamine

GDGBEX Amfetamine

GLYEEK amphetamine

H7SE4O Anfetamina

HCVNSQ amphetamine

HNG20U Amphetamine

HW0WRM Amphetamine

IBPJLJ amphetamine (caffine and creatine monohydrate also present)

ICQNLB Amphetamine

IIX7UR Caffeine

ISA8Y8 Amfetamine

IUW8JU Cafeine

IXUGYG Amfetamine

J28855 AMFETAMINE

J5YB55 amfetamine

JJLJOU amphetamine, caffeine

KBC4MU AMPHETAMINE

KHHK0G Amphetamine

KJU4OU Amphetamine,Caffeine



58

Code Identified SubstancesKLL25F Amphetamine

KNZKKP AMFETAMINE

KTJBZA amphetamine

KWPD3V amfetamine

KYO332 Amphetamine

L9LTEO Amfetamine

LEPP7L Caffeine

LFCJGM Amfetamine

LGECDN Amfetamine

LLLLTB amfetamine

LNR2DR Amphétamine

M5LL0L ANPHETAMINE

M9MFMP Amphetamine, caffeine

MBOMMM Amfetamine Sulfate

MCOLDO Amfetamine

MOOSOO amphetamine

MQXQRQ Amphetamine

MVVNXZ Amphetamine

NNNNDW Amphetamine

O1DHE1 Amphetamine mixed with caffeine

O28H4R Amp

OF6Y6D amfetamine

OFP7ET Amfetamine

OOOIMO Amphetamine

OOXOOI AMFETAMINE, CAFFEINE

OSTFUT amphetamine

OWRO6K Amphetamine

OYX2R3 ANFETAMINA

OZLPCC Amfetamine, Synthetic cathinones

P3Y0QX amfetamine

P5A5W5 Amfetamine

P7ZPBP Yes Amfetamine and Caffeine

PPPKPP Amphetamine

QOMLQQ Anfetamine

QS88SU Amphetamine

QUZQUQ Amfetamine

QWO4OF AMFETAMINE

R25T2B CAFFEINE

R2XKWH Amphetamine

R3QRYO Amphetami

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