INTERNATIONAL QUALITY ASSURANCE … · ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE...

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP)

INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Summary ReportSEIZED MATERIALS

2014/1

This report contains the data received from laboratories participating in the current exercise. The results compiled in this report are not intended to be an overview of the quality of work and cannot be interpreted as such. These comments do not reflect the general state of the art within the profession.

Participant results are reported using a randomly assigned "WebCode". This code maintains participant's anonymity, provides linking of the various report sections, and will change with every report.

Samples Substances Concentrations Comments on substances

Sample 1 1-(3-Chlorophenyl)piperazine 40.1 % sample also contained glucose

Sample 2 Metamfetamine 73.6 % sample also contained glucose

Sample 3 Ketamine 16.1 %

Lactose -

Sample 4 Cocaine 75.8 %

Test Samples InformationSamples Comments on samples

Sample 1 SM-1 was prepared from a seizure containing 40.1% w/w 1-(3-chlorophenyl)piperazine base.The seizure also contained glucose. Trace amounts of codeine and morphine were detected upon analysis of a concentrated solution. If detected, the trace components present need not be considered a false positive result.

Sample 2 SM-2 was prepared from a seizure containing 73.6% w/w Metamfetamine base.The samples also contained glucose and trace amounts of dimethylsulfone.

Sample 3 SM-3 was prepared from a seizure containing 16.1% w/w Ketamine base. The seizure also contained lactose.

Sample 4 SM-4 was prepared from a seizure containing 75.8% w/w cocaine base and trace amounts of benzoylecgonine and trans-cinnamoylcocaine.

2014/1-SM Copyright (c) 2014 UNODC

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP)INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Table of contents Introduction Page 3 Comments from the International Panel of Forensic Experts Page 4 NPS reported by ICE participants Page 5 Codes and Abbreviations Page 11 Sample 1 Analysis Page 12 Identified substances Page 12 Statement of findings Page 15 Identification methods 3 Summary Page 27 Z-Scores Page 28 Sample 2 Analysis Page 30 Identified substances Page 30 Statement of findings Page 34 Identification methods Page 42 Summary Page 46 Z-Scores Page 47 Sample 3 Analysis Page 49 Identified substances Page 49 Statement of findings Page 53 Identification methods Page 61 Summary Page 65 Z-Scores Page 66 Sample 4 Analysis Page 68 Identified substances Page 68 Statement of findings Page 72 Identification methods Page 73 Summary Page 83 Z-Scores Page 84

2

Introduction An important element of the UNODC International Quality Assurance Programme (IQAP) is the implementation of the International Collaborative Exercises (ICE). The exercises allow laboratories, from both developing and developed countries, to continuously monitor their performance in drug testing on a truly global scale. This report provides information on analytical results of laboratories participating in the Seized Materials (SM) group. In order to maintain confidentiality, the participating laboratories have been assigned random “Web Codes”, which change every round. Two rounds are offered per year with each round presenting participants with four different test samples for analysis. The analytical results returned by laboratories participating in ICE are evaluated by UNODC and a confidential report is provided to each laboratory on its own performance. The overall analytical results are reviewed by the UNODC’s International Panel of Forensic Experts which oversees the implementation of these exercises, and offers guidance and support in addressing relevant quality issues. The exercises provide an overview of the performance and capacity of participating laboratories and enable UNODC to tailor technical support in the laboratory sector for greatest impact.

Revision of calculation of z-scores in ICE

Following a recommendation from the International Panel of Forensic Experts and in order to allow ICE participants to interpret their z-scores in line with recommendations in ISO 13528:2005 and ISO/IEC guide 43-1:1997(E), UNODC have introduced an revision to the method used to calculate the z-scores. z-score is a statistical parameter used in proficiency tests and collaborative exercises as a measure of performance in quantitative analysis. They are calculated as:

z = (x-X)/ σ̂

where x = result of participant, X = assigned value of component being quantified and σ̂ is the standard deviation for proficiency assessment (SDPA). One of the methods recommended in ISO 13528:2005 for determining the assigned value X is to use the consensus value from participants. Using this method, the SDPA is also calculated from the standard deviation of the results of participants. Initial estimates of X and σ known as x* and s* are calculated as:

x* = median of xi (i = 1,2,……p) where p = number of participants s* = 1.483 median of │xi-x*│

Using these estimates, an iterative calculation (for details see ISO13528:2005, Annex C) is carried out to determine the final values of the robust average (x*) and robust standard deviation (s*) and the z-scores are calculated as

z = (xi-x*)/s* Consequently z-scores can be interpreted by participants in line with ISO 13528:2005, section 7.4.2 and ISO/IEC guide43-1:1997(E) as follows:

|z| < 2 = satisfactory 2 ≤ |z| ≤ 3 = questionable

|z| > 3 = unsatisfactory

According to the recommendations in ISO 13528:2005, an unsatisfactory z-score is considered to give an action signal and a questionable z-score is considered to give a warning signal. A single action signal or warning signals in two successive rounds shall be taken that an anomaly has occurred that requires investigation. UNODC would like to acknowledge the valuable contribution of the Chemical Metrology Laboratory of the Health Sciences Authority, Singapore, for the provision of specific software used for the quantitative statistical calculations in the ICE programme

3

Comments from the International Panel of Forensic Experts Participation of Laboratories In the 2014/1 round of the ICE programme, results were submitted within both the Seized Materials (SM) and Biological Specimens (BS) test groups by 182 laboratories in 59 countries. Within the SM test group, there were 151 participating laboratories from 57 countries, representing a 16% increase from the 2013/2 round. Within the BS test group, results were submitted by 72 laboratories from 38 countries, also corresponding to an increase of 16 % in the number of participants compared to the previous round. Qualitative Analysis The most commonly used technique for screening of test samples in the SM test group was the marquis reagent (42% of participants), while GC-MS (89%) was the most commonly used technique for identification/confirmation followed by FTIR (37%). The results for the qualitative identification of the controlled substances were excellent for all test samples in the SM group. 93% and 98% of participants correctly identified the 1-(3-chlorophenyl)piperazine and metamfetamine in SM-1 and SM-2 respectively. It is encouraging to note that 93% of participants identified the 1-(3-chlorophenyl)piperazine (94% identified this substance in 2013/2), indicating a continued excellent level of awareness of participants in the identification of this New Psychoactive Substance (NPS). 97% of participants correctly identified the ketamine in SM-3, an increase from 92% who correctly identified ketamine, when this was last used as a test sample in 2011/2. Finally, 99% of participants identified the cocaine in SM-4. 8 false positive results were reported for the four test samples in the SM group and there were only 7 false negative results. The detection limits of the different analytical techniques were taken into consideration when ascribing false positive results and as such laboratories who detected the trace amounts of Morphine and Codeine in SM-1 need not consider their results as false positives. Quantitative Analysis The proportion of participants who carried out quantitative analysis, 48 (32%) for SM-1, 83 (55%) for SM-2, 69 (46%) for SM-3 and 107 (71%) for SM-4 continues to be encouraging, particularly the high percentage of participants who quantified the cocaine in SM-4. 1-(3-chlorophenyl)piperazine is a relatively new substance In the ICE menu and there was a 5% increase in the number of laboratories who performed quantitative analysis for this drug compared to the previous round. It is also encouraging to note that 111 (74%) of participants in the SM test group performed quantitation. Of these, 38% quantified all test samples and 78% of laboratories quantified at least two of the 4 test samples. It is understood that quantitative analysis of controlled substances is often governed by local legislation and the requirements of prosecution. With regard to the analytical techniques used by participants performing quantitation, 50% used GC-FID, 24% used HPLC and 19% used GC-MS Analysis of the z-scores showed that 94% of participants provided acceptable quantitative results with |z| < 3 for 1-(3-chlorophenyl)piperazine in SM-1, 89% for metamphetamine in SM-2, 87% for ketamine in SM-3 and 87% for cocaine in SM-4. Laboratories are encouraged to carry out quantification as it can improve the quality of laboratory analyses and can be helpful in assessing the significance of the results. z-score values obtained assist participating laboratories in evaluating their performance and should be monitored over time as part of each laboratory’s quality assurance programme. Participants with z-scores outside acceptable limits should review their quantification procedures. Laboratories reporting false positive or false negative results should investigate the reasons for this and corrective actions should be taken in order to continuously improve performance. Participation in the ICE programme also helps in monitoring the effect of corrective actions.

4

New Psychoactive Substances (NPS) reported by laboratories participating

in the 2014/1 round of the ICE programme During the 2014/1 round of ICE, participating laboratories provided information on NPS that had been identified in their laboratories. In total there were 320 reports of 146 substances. The most commonly reported substances were synthetic cannabinoids followed by synthetic cathinones and phenethylamine group substances as shown in figure 1.

Figure 1. NPS reported by ICE laboratories during the 2014/1 round of ICE

The substances that were most commonly reported by participants are shown in table 1.

25I-NBOMe (1-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) was the substance most often reported

25C-NBOMe (1-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) and methylone (2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one) were equally the second most reported substances

The synthetic cannabinoids, APINACA (1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-1H-indazole-3-carboxamide) and MAM-2201 ([1-(5-Fluoropentyl)-1H-indol-3-yl](4-methyl-1-naphthalenyl)-methanone) completed the list.

32%

16% 19%

7%

14%

3% 3%

2% 1% 3%

Synthetic cannabinoids

Phenethylamines

Synthetic cathinones

Tryptamines

Others

Plant-based substances

Piperazines

Phencyclidine type substances

Aminoindanes

Unverified

5

Table 1. Substances most commonly reported by ICE participants in 2014/1 round of ICE

Substance IUPAC Name Structure

25I-NBOMe 2-(4-Iodo-2,5-dimethoxyphenyl)-N-(2-

methoxybenzyl)ethanamine

25C-NBOMe

2-(4-Chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine

Methylone 1-(1,3-Benzodioxol-5-yl)-2-(methylamino)propan-1-one

APINACA

1-Pentyl-N-(tricyclo[3.3.1.13,7]dec-2-yl)-1H-indazole-3-carboxamide - 1-(1,3-

benzodioxol-5-yl)-2-(methylamino)propan-1-one (1:1)

MAM-2201 [1-(5-Fluoropentyl)-1H-indol-3-yl](4-methylnaphthalen-1-yl)methanone

6

Table 2 shows the namesand structures of the NPS that were reported for the first time to UNODC during the 2014/1 round of ICE. Table 2. Substances reported to UNODC for the first time by ICE participants in 2014/1 round of ICE Common name/

Abbreviation IUPAC name Structure

Methoxphenidine, MXP

1-(1-(2-methoxyphenyl)-2-phenylethyl)piperidine

bk-MPA 2-(methylamino)-1-(thiophen-2-yl)propan-1-one

Carfentanyl

methyl 1-(2-phenylethyl)-4-[phenyl(propanoyl)amino]piperidi

ne-4-carboxylate

Diclazepam

7-chloro-5-(2-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-

benzodiazepin-2-one

Pyrazolam 8-bromo-1-methyl-6-(pyridin-2-

yl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

2-Fluoromethamphetamine, 2-FMA

1-(2-fluorophenyl)-N-methylpropan-2-amine

7

THJ-018 naphthalen-1-yl(1-pentyl-1H-indazol-3-yl)methanone

5F-AMB methyl N-{[1-(5-fluoropentyl)-1H-

indazol-3-yl]carbonyl}valinate

AB-CHMINACA

N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-

(cyclohexylmethyl)-1H-indazole-3-carboxamide

AB-FUBINACA(2-fluorobenzyl)

N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(2-

fluorobenzyl)-1H-indazole-3-carboxamide

FUB-PB-22 quinolin-8-yl-1-(4-fluorobenzyl)-1H-indole-3-carboxylate

8

Mepirapim, (4-methylpiperazin-1-yl)(1-pentyl-1H-indol-3-yl)methanone

PTI-2

N-(2-methoxyethyl)-N-{[2-(1-pentyl-1H-indol-3-yl)-1,3-thiazol-

4-yl]methyl}propan-2-amine

PTI-1

N-ethyl-N-{[2-(1-pentyl-1H-indol-3-yl)-1,3-thiazol-4-

yl]methyl}ethanamine

5F-NNE1

1-(5-fluoropentyl)-N-(naphthalen-1-yl)-1H-indazole-3-

carboxamide

THJ-2201 [1-(5-fluoropentyl)-1H-indazol-3-yl](naphthalen-1-yl)methanone

9

α-pyrrolidinoheptiop

henone, alpha-PHpP

1-phenyl-2-(pyrrolidin-1-yl)heptan-1-one

3-MePPP 1-(3-methylphenyl)-2-(pyrrolidin-

1-yl)propan-1-one

2-(ethylamino)-1-phenylpentan-1-one

2-MMC, 2-Methyl-N-

methylcathinone

2-(methylamino)-1-(2-methylphenyl)propan-1-one,

3,4-Dimethylethcathin

one

1-(3,4-dimethylphenyl)-2-(ethylamino)propan-1-one

2-(ethylamino)-1-(4-methylphenyl)pentan-1-one

bk-2C-B 2-amino-1-(4-bromo-2,5-

dimethoxyphenyl)ethanone

N-methyltryptamine

2-(1H-indol-3-yl)-N-methylethanamine

All laboratories participating in the UNODC International Collaborative Exercises can access the UNODC Early Warning Advisory on New Psychoactive Substances by logging on to their account and selecting the link as shown in the image below

10

Introduction An important element of the UNODC International Quality Assurance Programme (IQAP) is the implementation of the International Collaborative Exercises (ICE). The exercises allow laboratories, from both developing and developed countries, to continuously monitor their performance in drug testing on a truly global scale. This report provides information on analytical results of laboratories participating in the Seized Materials (SM) group. In order to maintain confidentiality, the participating laboratories have been assigned random “Web Codes”, which change every round. Two rounds are offered per year with each round presenting participants with four different test samples for analysis. The analytical results returned by laboratories participating in ICE are evaluated by UNODC and a confidential report is provided to each laboratory on its own performance. The overall analytical results are reviewed by the UNODC’s International Panel of Forensic Experts which oversees the implementation of these exercises, and offers guidance and support in addressing relevant quality issues. The exercises provide an overview of the performance and capacity of participating laboratories and enable UNODC to tailor technical support in the laboratory sector for greatest impact.

Revision of calculation of z-scores in ICE

Following a recommendation from the International Panel of Forensic Experts and in order to allow ICE participants to interpret their z-scores in line with recommendations in ISO 13528:2005 and ISO/IEC guide 43-1:1997(E), UNODC have introduced an revision to the method used to calculate the z-scores. z-score is a statistical parameter used in proficiency tests and collaborative exercises as a measure of performance in quantitative analysis. They are calculated as:

z = (x-X)/ σ̂

where x = result of participant, X = assigned value of component being quantified and σ̂ is the standard deviation for proficiency assessment (SDPA). One of the methods recommended in ISO 13528:2005 for determining the assigned value X is to use the consensus value from participants. Using this method, the SDPA is also calculated from the standard deviation of the results of participants. Initial estimates of X and σ known as x* and s* are calculated as:

x* = median of xi (i = 1,2,……p) where p = number of participants s* = 1.483 median of │xi-x*│

Using these estimates, an iterative calculation (for details see ISO13528:2005, Annex C) is carried out to determine the final values of the robust average (x*) and robust standard deviation (s*) and the z-scores are calculated as

z = (xi-x*)/s* Consequently z-scores can be interpreted by participants in line with ISO 13528:2005, section 7.4.2 and ISO/IEC guide43-1:1997(E) as follows:



According to the recommendations in ISO 13528:2005, an unsatisfactory z-score is considered to give an action signal and a questionable z-score is considered to give a warning signal. A single action signal or warning signals in two successive rounds shall be taken that an anomaly has occurred that requires investigation.

12

Comments from the International Panel of Forensic Experts

Participation of Laboratories In the 2014/1 round of the ICE programme, results were submitted within both the Seized Materials (SM) and Biological Specimens (BS) test groups by 182 laboratories in 59 countries. Within the SM test group, there were 151 participating laboratories from 57 countries, representing a 16% increase from the 2013/2 round. Within the BS test group, results were submitted by 72 laboratories from 38 countries, also corresponding to an increase of 16 % in the number of participants compared to the previous round. Qualitative Analysis The most commonly used technique for screening of test samples in the SM test group was the marquis reagent (42% of participants), while GC-MS (89%) was the most commonly used technique for identification/confirmation followed by FTIR (37%). The results for the qualitative identification of the controlled substances were excellent for all test samples in the SM group. 93% and 98% of participants correctly identified the 1-(3-chlorophenyl)piperazine and metamfetamine in SM-1 and SM-2 respectively. It is encouraging to note that 93% of participants identified the 1-(3-chlorophenyl)piperazine (94% identified this substance in 2013/2), indicating a continued excellent level of awareness of participants in the identification of this New Psychoactive Substance (NPS). 97% of participants correctly identified the ketamine in SM-3, an increase from 92% who correctly identified ketamine, when this was last used as a test sample in 2011/2. Finally, 99% of participants identified the cocaine in SM-4. 8 false positive results were reported for the four test samples in the SM group and there were only 7 false negative results. The detection limits of the different analytical techniques were taken into consideration when ascribing false positive results and as such laboratories who detected the trace amounts of Morphine and Codeine in SM-1 need not consider their results as false positives. Quantitative Analysis The proportion of participants who carried out quantitative analysis, 48 (32%) for SM-1, 83 (55%) for SM-2, 69 (46%) for SM-3 and 107 (71%) for SM-4 continues to be encouraging, particularly the high percentage of participants who quantified the cocaine in SM-4. 1-(3-chlorophenyl)piperazine is a relatively new substance In the ICE menu and there was a 5% increase in the number of laboratories who performed quantitative analysis for this drug compared to the previous round. It is also encouraging to note that 111 (74%) of participants in the SM test group performed quantitation. Of these, 38% quantified all test samples and 78% of laboratories quantified at least two of the 4 test samples. It is understood that quantitative analysis of controlled substances is often governed by local legislation and the requirements of prosecution. With regard to the analytical techniques used by participants performing quantitation, 50% used GC-FID, 24% used HPLC and 19% used GC-MS Analysis of the z-scores showed that 94% of participants provided acceptable quantitative results with |z| < 3 for 1-(3-chlorophenyl)piperazine in SM-1, 89% for metamphetamine in SM-2, 87% for ketamine in SM-3 and 87% for cocaine in SM-4. Laboratories are encouraged to carry out quantification as it can improve the quality of laboratory analyses and can be helpful in assessing the significance of the results. z-score values obtained assist participating laboratories in evaluating their performance and should be monitored over time as part of each laboratory’s quality assurance programme. Participants with z-scores outside acceptable limits should review their quantification procedures. Laboratories reporting false positive or false negative results should investigate the reasons for this and corrective actions should be taken in order to continuously improve performance. Participation in the ICE programme also helps in monitoring the effect of corrective actions.

13

New Psychoactive Substances (NPS) reported by laboratories participating

in the 2014/1 round of the ICE programme During the 2014/1 round of ICE, participating laboratories provided information on NPS that had been identified in their laboratories. In total there were 320 reports of 146 substances. The most commonly reported substances were synthetic cannabinoids followed by synthetic cathinones and phenethylamine group substances as shown in figure 1.

Figure 1. NPS reported by ICE laboratories during the 2014/1 round of ICE

The substances that were most commonly reported by participants are shown in table 1.

25I-NBOMe (1-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) was the substance most often reported

25C-NBOMe (1-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) and methylone (2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one) were equally the second most reported substances

The synthetic cannabinoids, APINACA (1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-1H-indazole-3-carboxamide) and MAM-2201 ([1-(5-Fluoropentyl)-1H-indol-3-yl](4-methyl-1-naphthalenyl)-methanone) completed the list.

32%

16% 19%

7%

14%

3% 3%

2% 1% 3%

Synthetic cannabinoids

Phenethylamines

Synthetic cathinones

Tryptamines

Others

Plant-based substances

Piperazines

Phencyclidine type substances

Aminoindanes

Unverified

14

Table 1. Substances most commonly reported by ICE participants in 2014/1 round of ICE

Substance IUPAC Name Structure

25I-NBOMe 2-(4-Iodo-2,5-dimethoxyphenyl)-N-(2-

methoxybenzyl)ethanamine

25C-NBOMe

2-(4-Chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine

Methylone 1-(1,3-Benzodioxol-5-yl)-2-(methylamino)propan-1-one

APINACA

1-Pentyl-N-(tricyclo[3.3.1.13,7]dec-2-yl)-1H-indazole-3-carboxamide - 1-(1,3-

benzodioxol-5-yl)-2-(methylamino)propan-1-one (1:1)

MAM-2201 [1-(5-Fluoropentyl)-1H-indol-3-yl](4-methylnaphthalen-1-yl)methanone

15

Table 2 shows the namesand structures of the NPS that were reported for the first time to UNODC during the 2014/1 round of ICE. Table 2. Substances reported to UNODC for the first time by ICE participants in 2014/1 round of ICE Common name/

Abbreviation IUPAC name Structure

Methoxphenidine, MXP

1-(1-(2-methoxyphenyl)-2-phenylethyl)piperidine

bk-MPA 2-(methylamino)-1-(thiophen-2-yl)propan-1-one

Carfentanyl

methyl 1-(2-phenylethyl)-4-[phenyl(propanoyl)amino]piperidi

ne-4-carboxylate

Diclazepam

7-chloro-5-(2-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-

benzodiazepin-2-one

Pyrazolam 8-bromo-1-methyl-6-(pyridin-2-

yl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

2-Fluoromethamphetamine, 2-FMA

1-(2-fluorophenyl)-N-methylpropan-2-amine

THJ-018 naphthalen-1-yl(1-pentyl-1H-indazol-3-yl)methanone

16

5F-AMB methyl N-{[1-(5-fluoropentyl)-1H-

indazol-3-yl]carbonyl}valinate

AB-CHMINACA

N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-

(cyclohexylmethyl)-1H-indazole-3-carboxamide

AB-FUBINACA(2-fluorobenzyl)

N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(2-

fluorobenzyl)-1H-indazole-3-carboxamide

FUB-PB-22 quinolin-8-yl-1-(4-fluorobenzyl)-1H-indole-3-carboxylate

Mepirapim, (4-methylpiperazin-1-yl)(1-pentyl-1H-indol-3-yl)methanone

17

PTI-2

N-(2-methoxyethyl)-N-{[2-(1-pentyl-1H-indol-3-yl)-1,3-thiazol-

4-yl]methyl}propan-2-amine

PTI-1

N-ethyl-N-{[2-(1-pentyl-1H-indol-3-yl)-1,3-thiazol-4-

yl]methyl}ethanamine

5F-NNE1

1-(5-fluoropentyl)-N-(naphthalen-1-yl)-1H-indazole-3-

carboxamide

THJ-2201 [1-(5-fluoropentyl)-1H-indazol-3-yl](naphthalen-1-yl)methanone

α-pyrrolidinoheptiop

henone, alpha-PHpP

1-phenyl-2-(pyrrolidin-1-yl)heptan-1-one

3-MePPP 1-(3-methylphenyl)-2-(pyrrolidin-

1-yl)propan-1-one

18

2-(ethylamino)-1-phenylpentan-1-one

2-MMC, 2-Methyl-N-

methylcathinone

2-(methylamino)-1-(2-methylphenyl)propan-1-one,

3,4-Dimethylethcathin

one

1-(3,4-dimethylphenyl)-2-(ethylamino)propan-1-one

2-(ethylamino)-1-(4-methylphenyl)pentan-1-one

bk-2C-B 2-amino-1-(4-bromo-2,5-

dimethoxyphenyl)ethanone

N-methyltryptamine

2-(1H-indol-3-yl)-N-methylethanamine

All laboratories participating in the UNODC International Collaborative Exercises can access the UNODC Early Warning Advisory on New Psychoactive Substances by logging on to their account and selecting the link as shown in the image below

19

Codes and Abbreviations

Tech Code Name

140 Colorimetric reactions

141 Marquis reagent (sulphuric acid, formaldehyde)

142 Cobalt thiocyanate

150 Thin Layer Chromatography

160 High/Ultra High Performance Liquid Chromatography

161 High Performance Liquid Chromatography with diode array detection

170 Gas Chromatography NPD

171 Gas Chromatography FID

172 Gas Chromatography ECD

180 Gas Chromatography/Mass Spectrometry

190 Fourier Transform Infrared Spectrometry

200 Spectrophotometry (visible, UV)

210 Others (specify)

211 NMR

220 Microcrystal test

230 Liquid chromatography/mass spectrometry

231 Liquid chromatography/tandem mass spectrometry

(+) “positive”: Indicates that the analyte is identified; for presumptive tests (e.g. colour reactions), indicates that a positive reaction was obtained.

(-) “negative”: Indicates that the analyte is not identified.

(ANP): Analysis not performed.



20

Identified substances for Test Sample 1

Code Identified Substances0LN2QE 1-(3-chlorophenyl)piperazine

0N05YR 1-(3-chlorophenyl)piperazine

0RE0L0 1-(3-chlorophenyl)piperazine, morphine, glucose

1SAEBM 1-(3-Chlorophenyl)piperazine

20LMZF 1-(3-Chlorophenyl)piperazine

28YACH 1-(3-Chlorophenyl) piperazine, Morphine

3BY3P6 1-(3- Chlorophenyl) piperazine

3MGTTL 1-(3-Chlorophenyl)piperazine

3RV3F7 m-cpp

3UMO3Y mCPP

3V0OFD 1-(3-Chlorophenyl)piperazine

4FA8F0 CPP

555YH5 1-(3-chlorophenyl)piperazine

5V22WM Chlorophenypiperazine

5WSWTT piperazines

5ZW2N9 1-(3-Chlorophenyl)piperazine

6306WG m-CPP

666F66 mCPP, morphine, codeine

7FH7HV Morphine et Méthamphétamine

7K1RKK Chlorophenyl piperazine

7WPIJX 1-(3-Chlorophenyl)piperazine

888Z8S 1-(3-Chlorophenyl)piperazine

8SVPRT 1-(3-chlorophenyl)piperazine

8YSG8M 1-(3-Chlorophenyl)piperazine and morphine

AEE5WA mCPP

AGNIZI 1-(3-Chlorophenyl)piperazine

AIPPIG m-CPP, 1-(3-chlorophenyl)piperazine

AJ22ZI 1-(3-chlorophenyl) piperazine

AKJ5JY CPP

ANHVML CPP and morphine (minor component)

BLZZMB mCPP: 1-(3-chlorophenyl)piperazine

BPLP0L mCPP

C9TTRY 1,3-chlorphenylpiperazine

CWGDML 1-(3-clhorophenyl )piperazine

CWLQJ1 1-(3-Chlorophenyl)piperazine

D5BVEI 1-(3-Chlorophenyl)piperazine

D8DHQW 1-(3-Chlorophenyl)piperazine

DFCXDG 1-(3-Chlorophenyl)piperazine

DLDLOB mCPP

DNKLDD 1-(3-Chlorophenyl)piperazine)

Sample 1 Analysis



21

Code Identified SubstancesDQMISD m-CPP

DYEYYG 1-(3-Chlorophenyl)piperazine

EDRLTN 1-(3-Chlorophenyl)piperazine

ELN44T 1-(3-Chlorophenyl)piperazine

EMZZIW MCPP, Morphine

FFFAFF m-Cpp

FIKSPK 1-(3-chlorophenyl)piperazine

FL6M38 1-(3-clorofenil)-piperazine

FO8JOE 1-(3-chlorophenyl)piperazine

GCGWXG 1-(3-chlorophenyl)piperazine and Morphine

GEZZ2P 1-(3-Chlorophenyl) piperazine

GK8FTC 1-(3-chlorophenyl)piperazine

H4TJQT codeine

H74EH5 m-CPP

HCW3AW 1-(3-Chlorophenyl)piperazine HCl

HYEPEU 1-(3-Chlorophenyl)piperazine

HYRH0O mCPP, Morphine

I3W3SW 1-(3-Chlorophenyl)piperazine

IJ37J2 1-(3-Chlorophenyl)piperazine

IM8WG1 1-(3-chlorophenyl)piperazine

IMEQDK Not identified

IOP7DS 1-(3-Chlorophenyl)piperazine

IRIBPI mCPP

IT3XHS 1-3 chloro -phenyl piperizine

J1X7S4 mCPP HCl

JA3JJQ 1-(3-Chlorophenyl)piperazine

JIRDRI 1-(3-Chlorophenyl)piperazine

KEANRN 1-(3 Chlorophenyl) piperazine

KGJIJS 1-(3-Chlorophenyl)piperazine

KN4PSK 1-(3-Chlorophenyl)piperazine

KPAKKD 1-(3-chlorophenyl)piperazine

KX18KO chlorophenyl piperazine, morphine

KYGWUS CHLORO PHENYL PIPERAZINE

LG45WT 1-(3-chlorophenyl)piperazine

LLLSLL mCPP HCl (1-(3-chlorophenyl)piperazine HCl)

LYWXR6 morphine and codeine

M1Q1F5 1-(3-Chlorophenyl)piperazine

MJHGVG mCPP

MRWDWG 1-(3-Chlorophenyl)piperazine

NBI4J4 1-(3-Chlorophenyl)piperazine

NHY1ZE morphine, codeine, 3-chlorphenylpiperazine

NSJNGB 1-(3-Chlorophenyl)piperazine

NU06C7 1-(3-Chlorophenyl)piperazine

NVENEN 1-(3-Chlorophenyl)piperazine



22

Code Identified SubstancesO2WSYF meta-chlorophenylpiperazine, traces of morphine and codeine

OGLNKI 1-(3-Chlorophenyl)piperazine

OLLRLR 1-(3-Chlorophenyl)piperazine

ORHNDM m-CPP

OW2RIV mCPP

PIRHNH 1-(3-Chlorophenyl)piperezine

PPHBGP 1,3 CLOROPHENYLPIPERAZINE

PSQS7F MORPHINE

Q11YO1 1-(3-Chlorophenyl)piperazine

Q8ECTW 1-(3-Chlorophenyl)piperazine

QIEBZB 1-(3-Chlorophenyl)piperazine

QOOCT8 1-(3-Chlorophenyl)piperazine

QTTSCI 1-(3-Chlophenyl)piperazine and codein

RJXPPP mCPP

RV9IZA Piperazine

RXKBFM 1-(3-clorofenil)pipirazina

S4B5OL 1-(3-Chlorophenyl)piperazine and Lactose

SAZ3ZW 1-(3-clorofenil)piperazina

SF9898 1-(3-Chlorophenyl)piperazine

SUOIOI 1-(3-Chlorophenyl)piperazine

TIILNU 1-(3-chlorophenyl)piperazine

TLVU3E mCPP

U54UUY HEROIN

UIIF4G 1-(3-Chlorophenyl)piperazine

ULQHBK 1-(3-chlorophenyl)piperazine

ULXUTD 1-(3-Chlorophenyl)piperazine

V3BKMA 1-(3-Chlorophenyl)piperazine

VGVOLX Morphine, 1-(3-Chloro Phenyl)Piperazine and Codeine

VJMKCE Morphine, Codeine and Chlorophenylpiperazine

VLJXIU 1-(3-chlorophenyl)piperazine

VMHH2Y mCPP

VXXFXK mCPP (1-(3-chlorophenyl)-piperazine)

VZSIJV 1-(3-chlorophenyl)piperazine and morphine

W33NYG m- CPP - Hcl; Heroine

XGELS2 Morphine and codéine

XL5KA0 1-(3-chlorophenyl)piperazine

XMAYN4 1-(3-chlorophenyl)piperazine, morphine, codeine

XVDW7X candidate molecule: mCPP

YVAVK8 mCPP: 1-(3-chlorophenyl)piperazine

YWZYAR m-CPP, morphine, codeine

YYDEDD Morphine, Codeine, mCPP

Z154TB mCPP

Z8YS9F 1-(3-Chlorophenyl)piperazine,Codeine,Morphine

ZZKXPP 1-(3-Chlorophenyl)piperazine



23

Code 1-(3-Chlorophenyl)piperazine

0J0PYS +

Sample one contains MCPP,HCL (25.2% as base) cut with glucose

0LN2QE +

1-(3-chlorophenyl)piperazine

0N05YR +

0RE0L0 +

The sample contains traces of morphine which is scheduled as illicit drug in France. 1-(3-chlorophenyl)piperazine is not scheduled as illicit drug in France. Glucose is a cutting agent.

1SAEBM +

Sample contains 37.7± 1.8 % (w/w) 1-(3-Chlorophenyl)piperazine base in HCL salt form.Trace amount of morphine and codeine were also detected by GC/MS. The sample also contains glucose.

20LMZF +

One glass bottle containing 0.21 grammes of a powder containing 0.08 grammes of 1-(3-chlorophenyl)piperazine.

28YACH +

1-(3-Chlorophenyl) piperazine, Morphine existed in salt form. We were found Codeine in the sample

2H9171 +

33HOOD +

Based on the above analysis, the sample was found to contain 1-(3-Chlorophenyl)piperazine and traces of morphine.

3BY3P6 +

3MGTTL +

3RV3F7 +

in the sample is m-cpp who is on the list of drugs in Montenegro

3UMO3Y +

white powder, also contain morphine, codeine and glucose

3V0OFD +

white powder containing 1-(3-Chlorophenyl)piperazine , not quantified. Contains also glucose.

4FA8F0 +

1-(3-chlorophenyl)piperazine

555YH5 +

5V22WM +

The powder was analysed and found to contain Chlorophenylpiperazine.

5WSWTT +

after chemical analysis was performed, the sample was found to contain piperazines.

5ZW2N9 +

1-(3-Chlorophenyl)piperazine was detected by GCMS screening

6306WG +

Unable to quantify due to lack of analytical standards

666F66 +

mCPP, morphine, codeine

Statement of findings for Test Sample 1



24


7FH7HV -

Après analyse, l'échantillon 2014/1/SM-1 contient de la morphine et de la méthamphétamine

7K1RKK +

A sample of the powder was analysed and found to contain chlorophenyl piperazine , which is a class C controlled substance under the Misuse of Drugs Act 1971

7WPIJX +

+lactose

888Z8S +

On analysis, I found the substance to contain MCPP

8GORYY +

The analysis did not reveal any controlled drug according to french order, decree of February 22nd 1990.

8SVPRT +

The result of the IR of test sample was shown same as those of the reference substance of 1-(3-chlorophenyl)piperazine

8YSG8M +

8ZZZO7 +

On analysis, I found the substances to contain 1-(3-chlorophenyl)piperazine

A3AH32 ANP

lactosa

AEE5WA +

AGNIZI +

mixture of 1-(3-Chlorophenyl)piperazine with lactose

AIPPIG +

White powder containing mCPP.

AJ22ZI +

The sample was found to contain 1-(3-chlorophenyl) piperazine

AKJ5JY +

Sample 2014/1/SM-1, a white, odourless powder, gave a positive result for CPP, a controlled substance under national legislation on drugs.

ANHVML +

Off-white powder containing (Chlorophenyl)piperazine (CPP) and morphine (as a minor component). Morphine is a Class A controlled drug and CPP is a Class C controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended).

BLZZMB +

contamination morphine

BPLP0L +

This sample is mCPP.

C9TTRY +

CWGDML +

CWLQJ1 +

The coincidence in the mass fragmentogram between the analyzed sample and a espectral library indicates the 1-(3-Chlorophenyl)piperazine presence.

CZV766 ANP

Label Non-Conformity: Sample coded "2013/2/SM-1" contrary to above. No test performed.



25


D5BVEI +

Powder containing 1-(3-Chlorophenyl)piperazine.

D8DHQW +

1-(3-Chlorophenyl)piperazine, a prohibited substance included in the National Law for Narcotics, is found to be present in this sample.

DFCXDG +

The sample contains m-CPP 45.04 %, m/m.

DLDLOB +

Identified substance:mCPP (1-(3-chlorophenyl)piperazine) the substance identified XXX its chemical structure a piperazine, concentration: approx 36 % as free base

DNKLDD +

DQEDDN +

DQMISD +

powder with 43,1 % of m-CPP as a active substance and glucose as a adulterant

DYEYYG +

1-(3-Chlorophenyl)piperazine and glucose

EBQAXY +

The sample 2014/1/SM-1 contains mCpp. mCpp is not a controlled substance in France

EDRLTN +

The exhibit item was found to contain 1-(3-Chlorophenyl)piperazine.

ELN44T +

On analysis, I found the sample to contain 1-(3-Chlorophenyl)piperazine (also known as mCPP)

EMZZIW +

ET1YHT +

47.7 % 1-(3-Chlorophenyl)piperazine

FFFAFF +

White powder that contains substance under control - m-Cpp.

FIKSPK +

It has been detecded that tehe subject of study including White colour dust substance was 1-(3-chlorophenyl)piperazine. This is a drug which is under the terms of national sunstance of drug Law 2313.

FL6M38 +

la muestra 2014/1(SM1) IS POSITIVE TO 1-(3-clorofenil)-piperazine, more traces of Morphine.

FO8JOE +

Retention time and MS spectra in GC analysis (FID and MS) compared with 3 isomers (o-, m-, p-)-CPP. Cloudy CHCl3 solution and FTIR/ATR indicates a mixture with some carbohydrate (e.g. glucose - confirmation not performed). mCPP as hydrochloride.

G222HF +

GCGWXG +

Chlorophenylpiperazine, known as CPP, is a class C controlled drug subject to the provisions of the Misuse of Drugs Act 1971 (Amendment) Order 2009 as it is structurally derived from 1-benzylpiperazine by substitution at the second nitrogen atom of the piperazine ring with a benzyl substituent. Morphine is a Class A controlled drug subject to the provisions of the Misuse of Drugs Act 1971.

GEZZ2P +



26


GK8FTC +

contain also traces of morphine and codeine

H4TJQT +

H74EH5 +

m-CPP 46,2 % and glucose

HCW3AW +

No color change with Marquis and Cobalt thiocyanate. Positive with Simon (Purple to Blue). Silver Nitrate Test--> Chloride Positive.TLC(TA,TE),GCMS -->1-(3-Chlorophenyl)piperazine confirmed. GC--> 1-(3-Chlorophenyl)piperazine base 40.68%

HCZG6T +

The sample was found to contain 1-(3-chlorophenyl)piperazine. In addition, trace amounts of morphine was also detected.

HYEPEU +

The powder is a psychotropic substance - 1-(3-Chlorophenyl)piperazine (m-CPP) powder. The powder contains 45.9 % pure m-CPP (base form).

HYRH0O +

mCPP, Morphine, Codeine

I3W3SW +

TRACES OF MORPHINE AND CODEINE WERE ALSO IDENTIFIED.

I9MZ11 +

SM-1 contained 1-(3-chlorophenyl)piperazine.

IJ37J2 +

In the test sample 2014/1/SM-1 was detected 1-(3-Chlorophenyl)piperazine

IM8WG1 +

IMEQDK ANP

Marquis reagent was negative at the begining, but a few seconds later, it turns into purple. The retention time was different from the heroin´s one, so we have our chromatogram with a single peak, but we can not identify any drug with our current method.

IOP7DS +

The sample contains 1-(3-Chlorophenyl)piperazine (not quantified).

IRIBPI +

We also found glucose and traces of morphine and codein

IT3XHS +

Red Precipitate with Dragendorff's Reagent indicates the possible presence of piperizine .Retention Time(RT 12.8) and Base peaks(154)of SM1 and library search in GCMS shows SM1 being 1-3 Chloro-Phenyl piperizine.We couldn't performed the percentage (Quantification)of SM1 because piperizine Reference Standard was not including in Ref Std box which you sent.

J1X7S4 +

SM1 contains also Glucose and trace amounts of morphine and codeine.

JA3JJQ +

1-(3-Chlorophenyl)piperazine

JIRDRI +

1-(3-Chlorophenyl) piperazine positive

K2D2PO +

we have found 1-(3-chlorophenyl)piperazine, but it`s not drug in Albania. In this sm-1 we have found also trace of codeine and morphine.



27


KEANRN +

In the tested sample was detected and confirmed the presence of 1 - (3 Chlorophenyl) piperazine plus codeine and morphine

KGJIJS +

SIGN IN DETECTED 2014/1/SM-1 labeled 1 - (3-Chlorophenyl) piperazine (mCPP).

KN4PSK +


KPAKKD +

The sample contains piperazine

KX18KO +

Off-white powder containing chlorophenyl piperazine which is a class C controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended).(Note: morphine would not be reported as detected at a very low level).

KYGWUS +

Vial containing 0.224 grams of off-white powder that was found to contain Chlorophenylpiperazine (CPP) . Chlorophenylpiperazine is controlled by the Misuse of Drugs Act 1971 (as amended) as a Class C drug, by virtue of the fact that it is structurally derived from Phenylpiperazine by substitution in the aromatic ring with a halide substituent

LG45WT +

The sample was soluble in water, ethanol and methanol.The sample had positive reaction for alkaloid with tanred reagent .The sample had positive reaction for chlorides with silver nitrate reagent .

LLLSLL +

mCPP HCl - not under control in Polish Lawadditional substance - glucose

LYWXR6 +

We have also found 1-(3-Chlorophenyl) piperazine (mCPP) which is a piperazine-like molecule. However, mCPP is not under illicit drugs legislation control in Spain.

M1Q1F5 +

The sample contain illegal drug meta-Chlorophenyl)piperazine (m-CPP)

MJHGVG +

hydrochloride form +GLUCOSE

MRWDWG +

white powder containing 1-(3-Chlorophenyl)piperazine, potential hazard substance, not considered under control in Italy.

NBI4J4 +

NHY1ZE +

SM1 contain opiates and psychoactive drugs.

NNBNTN +

1-(3-chlorophenyl)piperazine confirmed in one unit tested of one unit recieved. Not a controlled substance in the USA.

NSJNGB +


NU06C7 +

NVENEN +

The Sample 2014/1/SM1 was found to contain 1-(3-Chlorophenyl)Piperazine.

O2WSYF +

The sample is a preparation that contains meta-chlorophenylpiperazine and traces of morphine and codeine.



28


OGLNKI +


OLLRLR +

the white powder contains 1-(3-Chlorophenyl)piperazine . The amount of m-CPP was not determined because this laboratory hasn't got the correspondant certified reference material.

ORHNDM +

M-CPP , substance non classée stupéfiant

OW2RIV +

Sample containing mCPP

PF5IJN +

marquis, scott, chen cao. simon´s, FT-IR, HPLC

PIRHNH +

PPHBGP +

The results of the tests of the SM1 () received confirmed that the mentioned sample contains 1,3 CLOROPHENYLPIPERAZINE butwe are not able to give a cuantification result because we can not do it with our gas chromatography-gasspectometer and we have not got a gas chromatography FID which is the suitable analytical technique.

PSQS7F -

The simple No 2014/1/SM-1 was found MORFINE and PIPERAZINE 1(4-CLOROPHENYL)

Q11YO1 +

white powder containing 1-(3-Chlorophenyl)piperazine

Q8ECTW +

the powder is a mixture of 1-(3-Chlorophenyl)piperazine also known as mCPP and glucose. The concentration of mCPP in the sample is 29.9% by weight

QIEBZB +

The substance contains 39.40% of 1-(3-Chlorophenyl)piperazine

QOOCT8 +

Sample 2014/1/SM-1 was found to contain 1-(3-Chlorophenyl)piperazine.

QTTSCI +

Examination of the powder SM-1 revealed the presence of controlled drug 1-(3-Chlophenyl)piperazine.

RJXPPP +

RV9IZA +

RXKBFM +

S4B5OL +

The test sample 2014/1/SM-1 was analysed by colour test and Thin layer Chromatography (TLC) techniques and found to contain 1-(3-Chlorophenyl)piperazine and Lactose.

SAZ3ZW +

De acuerdo a los análisis realizados se concluye que se trata de 1-(3-clorofenil)piperazina

SF9898 +

1-(3-Chlorophenyl)piperazine was identified by TLC and GC/MS

SGDY90 +



29


SUOIOI +

made the chemical and instrumental analysis it resulted that the sample contains 1 - (3-Chlorophenyl) piperazine

TIILNU +

TLVU3E +

The sample SM1 contained 38.2 % m-CPP calculated as a base. In the sample was identified glucose, morphine and codeine.

U54UUY -

Field test employing the Marquis Test was positive as the spot turned purple. TLC analysis using two(2) solvents systems and HPLC confirmed the sample as HEROIN with purity 54.60%.

UIIF4G +

ULQHBK +

2014/1/SM-1 contains 1-(3-chlorophenyl)piperazine.

ULXUTD +

glucose

V3BKMA +

V43UFL +

mCPP, glucose, traces of morphine and codeine

VGVOLX +

MR and CT reagents: positive. GC/MS: Retention time, mass-charge (M/Z) similar characteristics with the substances used as standar or pattern.

VJMKCE +

A white powder containing MORPHINE, CODEINE and CHLOROPHENYLPIPERAZINE.

VLJXIU +

Was found DEXTROSA

VLLLV0 ANP

sin identificar

VMHH2Y +

VXXFXK +

morphine contamination by GC-MS

VZSIJV +

1-(3-chlorophenyl)piperazine is controlled (KB 22/01/1998 changed by KB 22/10/2006). Also a small amount of morphine (controlled KB 31/12/1930 changed by KB 8/10/1963) and codeine were found in the sample.

W33NYG +

To reach such a conclusion were performed the following tests:Preliminary tests: SCOOT REAGENT; MARQUIS REAGENT and SOLUBILITYConfirmation tests: Thin Layer Chromatography - TLC; Gas Chromatography Coupled to the Flame-Ionizacion Detector - GC/FID

XFPUFJ ANP

XGELS2 +

mCPP is not considerated as a drug (in France)

XH2D7F +



30


XL5KA0 +

Presence of 1-(3-chlorophenyl) piperazine hydrochloride and glucose was detected in the sample. The seizure also contained trace amount of codeine and morphine.

XMAYN4 +

*Results of screening tests were positive for opiates and piperazines. *Retention time and fragmentation pattern obtained with sample are equivalent to those obtained with 1-(3-chlorophenylpiperazine, morphine and codeine.

XVDW7X +

The sample SM-1 presents fragmentation pattern similar to the chemical substance 1-(3-Chlorophenyl)piperazine, also known as mCPP, which is included in List F2 (List of psychotropic substances banned in Brazil) of Annex I of SVS / MS 344, May 12, 1998. We can't confirm results due lack of mCPP standard.

YCYBYW -

YVAVK8 +

morphine

YWZYAR +

YYDEDD +

Z154TB +

The sample contain trace morphine

Z8YS9F +

-

ZM99S9 ANP

ZZKXPP +

CONFIRMED BY GC MS



31

Identification methods for Test Sample 1

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

0J0PYS S I I

0LN2QE I SI I

0N05YR S I I

0RE0L0 S S I I

1SAEBM S I I SI SI

20LMZF S S SI I

28YACH S I I

2H9171 SI

33HOOD S I

3BY3P6 S S S I I

3MGTTL I S

3RV3F7 S I I I

3UMO3Y SI I

3V0OFD I SI

4FA8F0 I I SI I

555YH5 S S S I I I SI I Tollens reagent

5V22WM S S I I

5WSWTT S S I I I

5ZW2N9 I SI

6306WG SI SI I I

666F66 SI SI SI I I

7FH7HV S I

7K1RKK S S I I GC/MS dERIVITISATION

7WPIJX S I I

888Z8S S S I

8GORYY I I

8SVPRT I SI

8YSG8M SI

8ZZZO7 S S S I

A3AH32 S S S I I

AEE5WA SI I

AGNIZI SI I I SI

AIPPIG S I SI SI I

AJ22ZI S I

Analytical Technique Codes

Legend: S ... used for Screening I ... used for Identification SI ... used for both



32

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

AKJ5JY S S I I

ANHVML S S I I

BLZZMB S I SI SI

BPLP0L S I I

C9TTRY S S S I

CWGDML S S I I S

CWLQJ1 S S I

CZV766 S S S SI

D5BVEI SI

D8DHQW SI S I I I

DFCXDG I SI I LC/RI

DLDLOB SI I GC-IRD

DNKLDD I SI

DQEDDN SI I

DQMISD SI I

DYEYYG S I

EBQAXY SI

EDRLTN I SI

ELN44T I SI

EMZZIW I SI

ET1YHT I SI S UPLC_PDA

FFFAFF SI S SI I S Simon's reagent

FIKSPK S I I

FL6M38 S S S I SI

FO8JOE I I I SI

G222HF S S I SI

GCGWXG S S I I

GEZZ2P S I

GK8FTC I SI FPIA

H4TJQT S S S I I I I

H74EH5 S I I I XRD

HCW3AW S S S I I

HCZG6T SI

HYEPEU S S I I

HYRH0O I SI

I3W3SW I SI

I9MZ11 S S I I I

IJ37J2 I

IM8WG1 S S SI SI



33

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

IMEQDK S S I

IOP7DS S S S I I

IRIBPI SI I

IT3XHS S S I I I Dragendorff test

J1X7S4 I S I I

JA3JJQ S I I

JIRDRI I SI

K2D2PO S S SI S duenois levin

KEANRN S SI SI

KGJIJS S S S I

KN4PSK I SI

KPAKKD SI

KX18KO S S S I I

KYGWUS S S I

LG45WT S S S I

LLLSLL I SI ATR

LYWXR6 I SI

M1Q1F5 SI ASAP-TOF

MJHGVG SI

MRWDWG

I SI

NBI4J4 SI S I I

NHY1ZE S SI I SI

NNBNTN SI I I I CE

NSJNGB I SI

NU06C7 SI S S I I SI

NVENEN S S S I I

O2WSYF I S I

OGLNKI SI

OLLRLR I SI

ORHNDM I SI I

OW2RIV SI I

PF5IJN S S S I I I

PIRHNH S I I

PPHBGP SI SI SI I

PSQS7F SI I

Q11YO1 SI

Q8ECTW I I I SI I I xrd

QIEBZB S S I S Simon

QOOCT8 S I



34

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

QTTSCI S SI

RJXPPP SI I

RV9IZA S SI

RXKBFM S S I I S tanred

S4B5OL S S SI I A

SAZ3ZW S S I SI Ion Mobility Spectrometry

SF9898 S S S I I

SGDY90 I I SI

SUOIOI S I

TIILNU S I I

TLVU3E I I

U54UUY S S S I I S Test strips

UIIF4G S I I

ULQHBK S S S I I

ULXUTD S I

V3BKMA S I I

V43UFL SI

VGVOLX S S I I

VJMKCE S S S I I

VLJXIU S S I I

VLLLV0 S S I

VMHH2Y I SI

VXXFXK S I SI SI

VZSIJV I S

W33NYG S S S I I

XFPUFJ I

XGELS2 I SI SI

XH2D7F I I

XL5KA0 S S S I I I I

XMAYN4 S S S I I

XVDW7X S S S I

YCYBYW SI

YVAVK8 S I SI SI

YWZYAR SI SI

YYDEDD SI I

Z154TB S I SI SI

Z8YS9F SI

ZM99S9 S S S I I

ZZKXPP SI I



35



Frequency of use of screening and identification techniques:

Summary for test sample 1The response summary of all 151 participating laboratories for the identification of SM-1, frequency of use of screening andidentification techniques and false positives and negatives:

Identification of test sample 1:

False positives for Test Sample 1

Code Name Technique

U54UUY Heroin 150/161

W33NYG Heroin 150/171

141 160

Response Summary Participants: 130

7FH7HV Metamfetamine 150

PSQS7F 1-(4-Chlorophenyl)piperazine 140/180

Section 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

Screening 52 63 50 14 0 2 0 3 57 16 3 0 0 0 9

34.4% 41.7% 33.1% 9.3% 0.0% 1.3% 0.0% 2.0% 37.7% 10.6% 2.0% 0.0% 0.0% 0.0% 6.0%

Identification 11 3 2 40 6 13 2 26 135 56 3 2 2 1 13

7.3% 2.0% 1.3% 26.5% 4.0% 8.6% 1.3% 17.2% 89.4% 37.1% 2.0% 1.3% 1.3% 0.7% 8.6%

# labs using this technique

55 63 50 47 6 14 2 27 135 59 4 2 2 1 18

36.4% 41.7% 33.1% 31.1% 4.0% 9.3% 1.3% 17.9% 89.4% 39.1% 2.6% 1.3% 1.3% 0.7% 11.9%


Response SummaryParticipants: 151

1-(3-Chlorophenyl)piperazine: 141

False negatives for SM-1 (techinque(s) used or ANP)

Code:7FH7HV (150), PSQS7F (140/180), U54UUY (150/161), YCYBYW (180), XFPUFJ (ANP) A3AH32 (ANP), CZV766 (ANP), IMEQDK (ANP), VLLLV0 (ANP) ZM99S9 (ANP)

36

Z-Scores for Test Sample 1



Concentration (mass%)

Deviation from robust

averagez-score

0J0PYS 25.2 -8.3 -0.90LN2QE 40.5 7.0 0.81SAEBM 37.7 4.2 0.520LMZF 39.0 5.5 0.628YACH 20.5 -13.0 -1.52H9171 29.6 -3.9 -0.43UMO3Y 37.8 4.3 0.5555YH5 5.9 -27.6 -3.1666F66 60.0 26.5 3.07WPIJX 18.0 -15.5 -1.88SVPRT 40.6 7.1 0.8AGNIZI 9.0 -24.5 -2.8BPLP0L 40.4 6.9 0.8D5BVEI 38.1 4.6 0.5DFCXDG 45.0 11.5 1.3DLDLOB 36.4 2.9 0.3DNKLDD 40.0 6.5 0.7DQEDDN 23.9 -9.6 -1.1DQMISD 43.1 9.6 1.1EMZZIW 20.0 -13.5 -1.5ET1YHT 47.7 14.2 1.6FIKSPK 26.0 -7.5 -0.9FO8JOE 39.0 5.5 0.6GEZZ2P 34.0 0.5 0.1H74EH5 46.2 12.7 1.4HCW3AW 40.7 7.2 0.8HYRH0O 24.0 -9.5 -1.1IJ37J2 24.0 -9.5 -1.1IM8WG1 31.9 -1.6 -0.2IRIBPI 34.1 0.6 0.1J1X7S4 34.2 0.7 0.1KN4PSK 31.6 -1.9 -0.2NNBNTN 38.6 5.1 0.6NSJNGB 32.2 -1.3 -0.2O2WSYF 17.4 -16.1 -1.8OGLNKI 31.9 -1.6 -0.2PF5IJN 23.4 -10.1 -1.2Q8ECTW 29.9 -3.6 -0.4QIEBZB 39.4 5.9 0.7QOOCT8 35.0 1.5 0.2RJXPPP 44.6 11.1 1.3SF9898 25.6 -7.9 -0.9SGDY90 30.0 -3.5 -0.4TLVU3E 38.2 4.7 0.5VZSIJV 38.1 4.6 0.5XH2D7F 18.9 -14.6 -1.7XL5KA0 35.0 1.5 0.2Z8YS9F 36.2 2.7 0.3


Code

37

crean

Sticky Note

Marked set by crean

Substance: SM-1/1-(3-Chlorophenyl)piperazine Robust average = 33.5UNODC value = 40.1

Round: 2014/1

Z-Score Report per Sample per Substance

‐3.1

‐2.8

‐1.8 ‐1.8 ‐1.7 ‐1.5 ‐1.5

‐1.1 ‐1.1

‐1.1

‐1.1 ‐0.9 ‐0.9 ‐0.9

‐0.4

‐0.4

‐0.4 ‐0.2

‐0.2

‐0.2

‐0.2

0.1

0.1

0.1 0.2

0.2 0.3

0.3 0.5

0.5 0.5

0.5

0.5 0.6 0.6

0.6 0.7 0.7 0.8

0.8

0.8

0.8 1.

1 1.2 1.3 1.4 1.6

3.0

‐4.0

‐3.0

‐2.0

‐1.0

0.0

1.0

2.0

3.0

4.0

555YH5

AGNIZI

O2W

SYF

7WPIJX

XH2D

7F

EMZZIW

28YA

CH

PF5IJN

DQED

DN

IJ37J2

HYRH

0O

0J0P

YS

SF9898

FIKSPK

2H9171

Q8ECT

W

SGDY

90

KN4P

SK

IM8W

G1

OGLN

KI

NSJNGB

GEZZ2P

IRIBPI

J1X7

S4

XL5K

A0

QOOCT

8

Z8YS9F

DLDL

OB

1SAE

BM

3UMO3Y

D5BV

EI

VZSIJV

TLVU

3E

NNBN

TN

20LM

ZF

FO8JOE

QIEBZ

B

DNKLDD

BPLP0L

0LN2Q

E

8SVP

RT

HCW3A

W

DQMISD

RJXP

PP

DFCX

DG

H74EH5

ET1YHT

666F66

z-scores can be interpreted by participants in line with ISO 13528:2005, section 7.4.2 and ISO/IEC guide43-1:1997(E) as follows:




38

crean

Sticky Note

Marked set by crean


Code Identified Substances0J0PYS metamfetamine

0LN2QE Metamfetamine

0N05YR methamphetamine

0RE0L0 metamfetamine

1SAEBM methamphetamine

20LMZF Methamphetamine hydrochloride

28YACH Metamfetamine

33HOOD Methamphetamine

3BY3P6 Metamfetamine

3MGTTL methamphetamine

3RV3F7 metamfetamine

3UMO3Y methamphetamine

3V0OFD methamphetamine

4FA8F0 Metamfetamine

555YH5 Metamfetamine

5V22WM Methylamphetamine

5WSWTT amphetamine

5ZW2N9 metamfetamine

6306WG metamphetamine

666F66 methamphetamine

7FH7HV Méthamphétamine

7K1RKK Methamphetamine

7WPIJX methamphetamine

888Z8S Metamphetamine

8GORYY Metamfetamine

8SVPRT metamfetamine

8YSG8M metamphetamine

8ZZZO7 methamphetamine

A3AH32 Metanfetamina

AEE5WA Methamphetamine

AGNIZI metamphetamine

AIPPIG Methamphetamine

AJ22ZI metamfetamine

AKJ5JY Methamphetamine

ANHVML Methylamphetamine

BLZZMB methamphetamine

BPLP0L methamphetamine

C9TTRY metamphetamine

CWGDML Methamphetamine

CWLQJ1 Metamfetamine

Sample 2 Analysis



39

Code Identified SubstancesCZV766 Methamphetamine

D5BVEI Methamphetamine

D8DHQW Metamfetamine

DFCXDG Metamfetamine

DLDLOB methamphetamine

DNKLDD Methamphetamine

DQMISD metamfetamine

DYEYYG Metamfetamine

EBQAXY Metamfetamine

EDRLTN Methylamphetamine

ELN44T Methamphetamine

EMZZIW Methamphetamine

ET1YHT Metamfetamine

FFFAFF methamphetamine

FIKSPK Metamfetamine

FL6M38 Metamfetamine

FO8JOE metamfetamine

GCGWXG N-Methylamphetamine

GEZZ2P Metamfetamine

GK8FTC methamphetamine

H74EH5 Metanphetamine hcl

HCW3AW Methamphetamine HCl

HCZG6T Methamphetamine

HYEPEU Methamphetamine

HYRH0O Metamphetamine

I3W3SW METHAMFETAMINE

I9MZ11 Metamfetamine

IJ37J2 Metamfetamine

IM8WG1 Metamfetamine

IMEQDK Metamfetamine

IOP7DS Metamfetamine

IRIBPI Metamfetamine

IT3XHS Methamphetamine

J1X7S4 Methamphetamine HCl

JA3JJQ Metamfetamine

JIRDRI Metamfetamine

K2D2PO Methamphetamine

KEANRN Metamfetamine

KGJIJS Metamfetamine

KPAKKD Metamfetamine

KX18KO Methylamphetamine hydrochloride

KYGWUS Methylamphetamine

LG45WT Metamfetamine

LLLSLL metamphetamine HCl



40

Code Identified SubstancesLYWXR6 Metamfetamine

M1Q1F5 Metamphetamine

MJHGVG METHAMPHETAMINE

MRWDWG metamfetamine

NBI4J4 Metamfenamine

NHY1ZE Methamphetamine

NNBNTN d-methamphetamine hydrochloride

NSJNGB Metamfetamine

NU06C7 Metamfetamine 72,5%

NVENEN Amfetamine

O2WSYF methamphetamine

OGLNKI Metamfetamine

OLLRLR methamphetamine

ORHNDM metamphétamine

OW2RIV Methamfatamine

PF5IJN METANFETAMINA

PIRHNH metamfetamine

PPHBGP METAMPHETAMINE

PSQS7F METHANPHETAMINE

Q11YO1 metamfetamine

Q8ECTW methamphetamine

QIEBZB Metamfetamine

QOOCT8 Metamfetamine

QTTSCI Methamphetamine

RJXPPP Metamphetamine

RV9IZA , Methamphetamine

RXKBFM metanfetamina

S4B5OL Metamfetamine

SAZ3ZW Metanfetamina

SF9898 Metamfetamine

SUOIOI Methamphetamine

TIILNU Methamphetamine

TLVU3E Methamphetamine

U54UUY METHAMPHETAMINE

UIIF4G Metanfetamina

ULQHBK Methamphetamine

ULXUTD metamfetamine

V3BKMA Metamfetamine

V43UFL metamfetamine, HCl

VGVOLX Metamfetamine

VJMKCE Methylamphetamine Hydrochloride

VLJXIU Metamfetamine

VLLLV0 metanfetamina

VMHH2Y Methamfetamine



41

Code Identified SubstancesVXXFXK metamfetamine

VZSIJV metamfetamine

W33NYG Methanphetamine

XFPUFJ methamphetanime

XGELS2 Metamfetamine

XH2D7F metamphetamine

XL5KA0 Metamfetamine

XMAYN4 metamfetamine

XVDW7X methamphetamine

YCYBYW Metamphetamine

YVAVK8 methamphetamine

YWZYAR methampetamine

YYDEDD Methamfetamine

Z154TB methamphetamine

Z8YS9F Metamfetamine

ZM99S9 Methamphetamine

ZZKXPP METHANPHETAMINE



42

Code Metamfetamine

0J0PYS +

Sample two contains metamfetamine,HCL (73.3% as base)

0LN2QE +

Metamfetamine

0N05YR +

0RE0L0 +

The sample contains metamfetamine which is scheduled as illicit drug in France.

1SAEBM +

Sample contains 72.6± 3.2 % (w/w) methamphetamine base in HCL salt form.

20LMZF +

One glass bottle containing 0.22 grammes of a powder containing 0.20 grammes of methamphetamine hydrochloride (a salt of methamphetamine).

28YACH +

Metamfetamine existed in salt form.

2H9171 +

33HOOD +

Based on the above analysis, the sample was found to contain methamphetamine.

3BY3P6 +

White powder was found to contain Metamfetamine.

3MGTTL +

3RV3F7 +

in the sample ismetamfetamine who is on the list of drugs in Montenegro

3UMO3Y +

white powder, also contain dimethylsulfone

3V0OFD +

white powder containing 74.7% metamphetamine

4FA8F0 +

Metamfetamine

555YH5 +

5V22WM +

The powder was analysed and found to contain Methylamphetamine.

5WSWTT -

after chemical analysis was performed, the sample was found to contain 84.9% amphetamine.

5ZW2N9 +

metamfetamine was detected by GC/MS screening and it was confirmed and quantified by GC-FID using calibration curve

6306WG +

666F66 +

methamphetamine

7FH7HV +

L'échantillon 2014/1/SM-2 contient de la méthamphétamine




43

Code Metamfetamine

7K1RKK +

A sample of the powder was analysed and found to contain methamphetamine, which is a class A controlled substance under the Misuse of Drugs Act 1971.

7WPIJX +

+creatinine

888Z8S +

On analysis, I found the substance to contain 70.5% Methamphetamine

8GORYY +

The sample contains metamfetamine which is listed as a controlled drug according to french order, appendix III of February 22nd 1990.

8SVPRT +

The results of TLC of test sample and reference substance was same as metamfetamine. the peak of IR of test sample was shown same as metamfetamine

8YSG8M +

found methamphetamine with 64.0% w/w

8ZZZO7 +

On analysis, I found the sustances to contain 70.33% (by weight) of methamphetamine

A3AH32 +

Metanfetamina

AEE5WA +

AGNIZI +

AIPPIG +

White powder containing methamphetamine.

AJ22ZI +

The sample was found to contain metamfetamine

AKJ5JY +

Sample 2014/1/SM-2, a white, odourless powder, gave a positive result for Methamphetamine, a controlled substance under national legislation on drugs.

ANHVML +

White powder containing an average of 73% methylamphetamine. Methylamphetamine is a Class A controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended).

BLZZMB +

dimethylsulfone

BPLP0L +

This sample is methamphetamine.

C9TTRY +

CWGDML +

CWLQJ1 +

The chemical tests and the coincidence in the time of retention and mass fragmentogram with the material reference used in the same conditions that the analyzed sample, they indicates in this one the metanfetamine's presence.

CZV766 +

The white powder contains Methamphetamine.

D5BVEI +

Powder containing methamphetamine.



44

Code Metamfetamine

D8DHQW +

Metamfetamine, a prohibited substance included in the National Law for Narcotics, is found to be present in this sample.

DFCXDG +

The sample contains metamfetamine 75.62 %, m/m.

DLDLOB +

narcotics: methamphetamineconcentration: approx 79 % as free base

DNKLDD +

DQEDDN +

DQMISD +

powder with 74,7 % of metamfetamine as a active substance and DMS as a adulterant

DYEYYG +

Metamfetamine

EBQAXY +

The sample 2014/1/SM-2 contains 70% of metamfetamine.Metamfetamine is a controlled substance in France

EDRLTN +

The exhibit item was found to contain Methylamphetamine

ELN44T +

On analysis, I found the sample to contain methamphetamine

EMZZIW +

ET1YHT +

85.7 % Metamfetamine

FFFAFF +

White powder that contains substance under control - methamphetamine.

FIKSPK +

It has been detecded that tehe subject of study including White colour dust substance was Metamfetamine. This is a drug which is under the terms of national sunstance of drug Law 2313.

FL6M38 +

metamfetamine

FO8JOE +

Retention time and MS spectra in GC analysis (FID and MS) compared with ICE reference material. Metamfetamine as hydrochloride.

G222HF +

GCGWXG +

N-Methylamphetamine is a Class A controlled drug subject to the provisions of the Misuse of Drugs Act 1971.

GEZZ2P +

GK8FTC +

H4TJQT +

H74EH5 +

Base Metanphetamine 77,5%



45

Code Metamfetamine

HCW3AW +

Positive with Marquis (orange turn to brown). Positive with Simon (Blue). Silver Nitrate Test--> Chloride Positive.TLC(TA,TE),GCMS -->Methamphetamine confirmed, and trace of Dimethyl sulfone found. GC--> Methamphetamine base 71.38%

HCZG6T +

The sample was found to contain 72.8% of methamphetamine (as base).

HYEPEU +

The powder is a psychotropic substance - methamphetamine powder. The powder contains 76.6 % pure methamphetamine (base form).

HYRH0O +

Metamphetamine

I3W3SW +

METHAMFETAMINE IS PRESENT IN HYDROCHLORIDE FORM.

I9MZ11 +

SM-2 contained Metamfetamine

IJ37J2 +

In the test sample 2014/1/SM-2 was detected Metamfetamine

IM8WG1 +

IMEQDK +

IOP7DS +

The sample contains metamfetamine (72.4%).

IRIBPI +

IT3XHS +

Orange changes to brown color in Marquis Reagent indicates the possible presence of methamphetamine.By TLC,Rf and color of std Methamphetamine are equal to those of SM2.Retention Time (RT12.833) and Base peaks( 138.05 ) of SM2 are mostly identical to std methamphetamine and library search in GCMS shows SM2 being Methamphetamine.

J1X7S4 +

SM2 contains also Dimethylsulfone.

JA3JJQ +

Metamfetamine

JIRDRI +

metemfetamine positive

K2D2PO +

KEANRN +

In the tested sample was detected and confirmed the presence of metamfetamine

KGJIJS +

SIGN IN DETECTED Metamfetamine 2014/1/SM-2 labeled.

KN4PSK +

Metamfetamine

KPAKKD +

The sample contains metamfetamine

KX18KO +

White powder containing Methylamphetamine which is a class A controlled drug with a purity of 72% (as base) under the provisions of the Misuse of Drugs Act 1971 (as amended).



46

Code Metamfetamine

KYGWUS +

O.229 grams of off white powder found to contain methylamphetamine at a concentration of 74%. Methylamphetamine is controlled by the Misuse of Drugs Act 1971 (as amended) as a Class A drug

LG45WT +

The sample was soluble in water and ethanol.The sample had positive reaction for amphetamine with marquis reagent .

LLLSLL +

LYWXR6 +

We have also found dimethylsulphone, which is a synthesis product and also a common adulterant agent for Metamfetamine.

M1Q1F5 +

The sample contain controlled drug metamphetamine

MJHGVG +

hydrochloride form

MRWDWG +

white powder containing 73.2%mM7 of metamfetamine

NBI4J4 +

NHY1ZE +

SM2 was contain methamphetamine

NNBNTN +

d-methamphetamine hydrochloride and dimethyl sulfone confirmed in one unit tested of one unit recieved.

NSJNGB +

Metamfetamine

NU06C7 +

NVENEN +

The Sample 2014/1/SM2 was found to contain Amfetamine.

O2WSYF +

The sample is identified as methamphetamine

OGLNKI +

Metamfetamine

OLLRLR +

the white powder contains metamphetamine (74.4%w/w), which is controlled bt national law

ORHNDM +

métamphétamione,substance classée stupéfiant

OW2RIV +

Sample containing Methamfetamine

PF5IJN +

MARQUIS, SCOTT, SIMON´S, UV, HPLC, GC-MS, FT-IR, HPLC

PIRHNH +



47

Code Metamfetamine

PPHBGP +

The results of the tests of the SM2 () received confirmed that the mentioned sample contains METAMPHETAMINE butwe are not able to give a cuantification result because we can not do it with our gas chromatography-gasspectometer and we have not got a gas chromatography FID which is the suitable analytical technique.The sample 2 also contains caffein as not controlled drug.

PSQS7F +

The simple No 2014/1/SM-2 was found METHANPHETAMINE

Q11YO1 +

white powder containing metamfetamine

Q8ECTW +

The powder contains methamphetamine with a concentration in the sample of 73.6% by weight as free base

QIEBZB +

The substance contains 74.96% of Metamfetamine

QOOCT8 +

Sample 2014/1/SM-2 was found to contain Metamfetamine.

QTTSCI +

Examination of the powder SM-2 revealed the presence of controlled drug Methamphetamine

RJXPPP -

RV9IZA +

RXKBFM +

S4B5OL +

The test sample 2014/1/SM-2 was analysed by colour test and Thin layer Chromatography (TLC) techniques and found to contain Metamfetamine.

SAZ3ZW +

De acuerdo a los análisis realizados se concluye que se trata Metanfetamina

SF9898 +

Metamfetamine was identified by TLC and GC/MS

SGDY90 +

SUOIOI +

I made the chemical and instrumental analysis it resulted that the sample contains methamphetamine

TIILNU +

TLVU3E +

The sample SM2 contained 73.8 % methamphetamine calculated as a base. In the sample was identified dimethylsulphone (MSM).

U54UUY -

Field Test employing the Marquis Test was positive because the spot was brown. TLC analysis employing two(2) solvent systems and HPLC confirmed the sample as Methamphetamine.

UIIF4G +

ULQHBK +

2014/1/SM-2 contains Methamphetamine.



48

Code Metamfetamine

ULXUTD +

V3BKMA +

V43UFL +

VGVOLX +

MR and CT reagents: positive. GC/MS: Retention time, mass-charge (M/Z) similar characteristics with the substances used as standar or pattern. FTIR: Absorption bands conicident with the substances used as pattern

VJMKCE +

A white powder containing an average of 91% of METHYLAMPHETAMINE HYDROCHLORIDE

VLJXIU +

VLLLV0 +

VMHH2Y +

VXXFXK +

dimetil-sulfone

VZSIJV +

metamfetamine is controlled (KB 22/01/1998)

W33NYG +

In this sample were performed the same tests but with preliminary testing (MARQUIS reagent) coloration is not very clear for that class of drugs (amphetamines and their derivatives), or thin-layer Cromatofrafia-TLC and even gas chromatography coupled to the flame-Ionization Detector GC/FID but according to the obtained results it was verified that we are in the presence of methamphetamine.

XFPUFJ +

XGELS2 +

XH2D7F +

Illegal substances on the basis of the italian law DPR 309/90

XL5KA0 +

Presence of metamfetamine hydrochloride was detected in the sample.

XMAYN4 +

*Results of screening tests were positive for metamfetamine. *Retention time and fragmentation pattern obtained with sample are equivalent to those obtained with metamfetamine.

XVDW7X +

The sample SM-2 contains methamphetamine, which is included in List F2 (List of psychotropic substances banned in Brazil) of Annex I of SVS / MS 344, May 12, 1998.

YCYBYW +

YVAVK8 +

dimethylsulfone

YWZYAR +

dimethylsulfone

YYDEDD +



49

Code Metamfetamine

Z154TB +

Z8YS9F +

ZM99S9 +

The sample obtains with the positive result with Marquis reagent.TLC : The Rf sample obtain with the same Rf Methamphetamine standard.GC: The Rt sample obtain with the same Rt Methamphetamine standard.

ZZKXPP +

CONFIRMED BY GC MS



50


Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

0J0PYS S I I

0LN2QE I SI I

0N05YR S I I

0RE0L0 S S I I

1SAEBM S I I SI SI

20LMZF S S SI I

28YACH S I I

2H9171 SI

33HOOD S I

3BY3P6 S S S I I

3MGTTL I S

3RV3F7 S I I I

3UMO3Y SI I

3V0OFD I SI

4FA8F0 I I SI I


5V22WM S S I I

5WSWTT S S I I I

5ZW2N9 I SI

6306WG SI SI I I

666F66 SI SI SI I I

7FH7HV S I


7WPIJX S I I

888Z8S S S I

8GORYY I I

8SVPRT I SI

8YSG8M SI

8ZZZO7 S S S I

A3AH32 S S S I I

AEE5WA SI I

AGNIZI SI I I SI

AIPPIG S I SI SI I

AJ22ZI S I





51

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

AKJ5JY S S I I

ANHVML S S I I

BLZZMB S I SI SI

BPLP0L S I I

C9TTRY S S S I

CWGDML S S I I S

CWLQJ1 S S I

CZV766 S S S SI

D5BVEI SI

D8DHQW SI S I I I

DFCXDG I SI I LC/RI

DLDLOB SI I GC-IRD

DNKLDD I SI

DQEDDN SI I

DQMISD SI I

DYEYYG S I

EBQAXY SI

EDRLTN I SI

ELN44T I SI

EMZZIW I SI



FIKSPK S I I

FL6M38 S S S I SI

FO8JOE I I I SI

G222HF S S I SI

GCGWXG S S I I

GEZZ2P S I

GK8FTC I SI FPIA


H74EH5 S I I I XRD

HCW3AW S S S I I

HCZG6T SI

HYEPEU S S I I

HYRH0O I SI

I3W3SW I SI

I9MZ11 S S I I I

IJ37J2 I

IM8WG1 S S SI SI



52

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

IMEQDK S S I

IOP7DS S S S I I

IRIBPI SI I


J1X7S4 I S I I

JA3JJQ S I I

JIRDRI I SI


KEANRN S SI SI

KGJIJS S S S I

KN4PSK I SI

KPAKKD SI

KX18KO S S S I I

KYGWUS S S I

LG45WT S S S I

LLLSLL I SI ATR

LYWXR6 I SI

M1Q1F5 SI ASAP-TOF

MJHGVG SI

MRWDWG

I SI

NBI4J4 SI S I I

NHY1ZE S SI I SI

NNBNTN SI I I I CE

NSJNGB I SI


NVENEN S S S I I

O2WSYF I S I

OGLNKI SI

OLLRLR I SI

ORHNDM I SI I

OW2RIV SI I

PF5IJN S S S I I I

PIRHNH S I I

PPHBGP SI SI SI I

PSQS7F SI I

Q11YO1 SI



QOOCT8 S I



53

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

QTTSCI S SI

RJXPPP SI I

RV9IZA S SI


S4B5OL S S SI I A


SF9898 S S S I I

SGDY90 I I SI

SUOIOI S I

TIILNU S I I

TLVU3E I I


UIIF4G S I I

ULQHBK S S S I I

ULXUTD S I

V3BKMA S I I

V43UFL SI

VGVOLX S S I I

VJMKCE S S S I I

VLJXIU S S I I

VLLLV0 S S I

VMHH2Y I SI

VXXFXK S I SI SI

VZSIJV I S

W33NYG S S S I I

XFPUFJ I

XGELS2 I SI SI

XH2D7F I I


XMAYN4 S S S I I

XVDW7X S S S I

YCYBYW SI

YVAVK8 S I SI SI

YWZYAR SI SI

YYDEDD SI I

Z154TB S I SI SI

Z8YS9F SI

ZM99S9 S S S I I

ZZKXPP SI I



54







Code Name Technique

NVENEN Amfetamine 180

141 160


5WSWTT Amfetamine 180/200

W33NYG MDEA 150/171

Section 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

Screening 52 63 50 14 0 2 0 3 57 16 3 0 0 0 9

34.4% 41.7% 33.1% 9.3% 0.0% 1.3% 0.0% 2.0% 37.7% 10.6% 2.0% 0.0% 0.0% 0.0% 6.0%

Identification 11 3 2 40 6 13 2 26 135 56 3 2 2 1 13

7.3% 2.0% 1.3% 26.5% 4.0% 8.6% 1.3% 17.2% 89.4% 37.1% 2.0% 1.3% 1.3% 0.7% 8.6%


55 63 50 47 6 14 2 27 135 59 4 2 2 1 18

36.4% 41.7% 33.1% 31.1% 4.0% 9.3% 1.3% 17.9% 89.4% 39.1% 2.6% 1.3% 1.3% 0.7% 11.9%



Code: U54UUY (150/161), RJXPPP (180/230) 5WSWTT (180)


Metamfetamine: 148

55






averagez-score

I3W3SW 72.8 -1.0 -0.3I9MZ11 70.4 -3.4 -0.9IJ37J2 73.0 -0.8 -0.2

IM8WG1 75.2 1.4 0.4IMEQDK 88.3 14.5 4.1IOP7DS 72.4 -1.4 -0.4IRIBPI 77.3 3.5 1.0IT3XHS 94.7 20.9 5.8J1X7S4 74.0 0.2 0.1K2D2PO 77.6 3.8 1.1KN4PSK 76.2 2.4 0.7KX18KO 72.0 -1.8 -0.5KYGWUS 74.0 0.2 0.1LLLSLL 70.0 -3.8 -1.1

LYWXR6 72.0 -1.8 -0.5MRWDWG 73.2 -0.6 -0.2NHY1ZE 11.0 -62.8 -17.5NNBNTN 72.6 -1.2 -0.3NSJNGB 75.2 1.4 0.4NU06C7 72.5 -1.3 -0.4OGLNKI 74.7 0.9 0.3OLLRLR 74.4 0.6 0.2PF5IJN 78.6 4.8 1.3

Q8ECTW 73.6 -0.2 0.0QIEBZB 75.0 1.2 0.3QOOCT8 66.0 -7.8 -2.2RJXPPP 77.5 3.7 1.0SF9898 21.6 -52.2 -14.5SGDY90 70.0 -3.8 -1.1TLVU3E 73.8 0.0 0.0ULXUTD 72.8 -1.0 -0.3V3BKMA 72.6 -1.2 -0.3V43UFL 76.0 2.2 0.6VJMKCE 73.0 -0.8 -0.2VZSIJV 76.9 3.1 0.9XH2D7F 86.7 12.9 3.6XL5KA0 74.6 0.8 0.2XVDW7X 79.6 5.8 1.6YCYBYW 83.5 9.7 2.7YYDEDD 70.1 -3.8 -1.0Z8YS9F 67.1 -6.7 -1.9ZM99S9 39.9 -33.9 -9.4

Code

Metamfetamine



averagez-score

0J0PYS 73.3 -0.5 -0.10LN2QE 73.4 -0.4 -0.10RE0L0 76.0 2.2 0.61SAEBM 72.6 -1.2 -0.320LMZF 72.6 -1.2 -0.328YACH 72.5 -1.3 -0.42H9171 71.3 -2.5 -0.73UMO3Y 72.5 -1.3 -0.43V0OFD 74.7 0.9 0.3555YH5 78.6 4.8 1.45ZW2N9 15.1 -58.7 -16.46306WG 68.1 -5.7 -1.6666F66 79.0 5.2 1.57WPIJX 79.0 5.2 1.5888Z8S 70.5 -3.3 -0.98GORYY 74.6 0.8 0.28YSG8M 64.0 -9.8 -2.78ZZZO7 70.3 -3.5 -1.0AEE5WA 80.0 6.2 1.7AGNIZI 72.0 -1.8 -0.5ANHVML 73.0 -0.8 -0.2BPLP0L 74.4 0.6 0.2D5BVEI 72.2 -1.6 -0.4DFCXDG 75.6 1.8 0.5DLDLOB 78.9 5.1 1.4DNKLDD 73.5 -0.3 -0.1DQEDDN 71.2 -2.6 -0.7DQMISD 74.7 0.9 0.3DYEYYG 70.7 -3.1 -0.9EBQAXY 70.0 -3.8 -1.1EDRLTN 72.9 -0.9 -0.2EMZZIW 85.0 11.2 3.1ET1YHT 85.7 11.9 3.3FIKSPK 69.0 -4.8 -1.3FO8JOE 76.7 2.9 0.8GEZZ2P 73.0 -0.8 -0.2H74EH5 77.5 3.7 1.0

HCW3AW 71.4 -2.4 -0.7HCZG6T 72.8 -1.0 -0.3HYEPEU 76.0 2.2 0.6HYRH0O 81.9 8.1 2.3

Code

Metamfetamine

56

Substance: SM-2/Metamfetamine

Round: 2014/1


Robust average = 73.8UNODC value = 73.6

‐2.7

‐2.2‐1.9 ‐1

.6 ‐1.3 ‐1

.0‐1.0

‐1.0

‐1.0 ‐1.0

‐0.9

‐0.9 ‐0.9 ‐0.7

‐0.7

‐0.7 ‐0.5

‐0.5

‐0.5 ‐0.4 ‐0.4

‐0.3

‐0.3

‐0.3

‐0.3

‐0.3

‐0.3

‐0.3 ‐0.3

‐0.3

‐0.3

‐0.2

‐0.2

‐0.2

‐0.2

‐0.2 ‐0.2

‐0.1

‐0.1

‐0.1 0.0

0.0 0.1

0.1 0.2

0.2 0.2

0.2 0.3

0.3

0.3 0.3 0.4

0.4 0.5 0.6

0.6

0.6 0.7 0.8 0.9 1.0 1.0

1.0 1.11.3

1.4 1.4 1.5

1.5 1.6 1.7

2.3

2.7

3.1 3.33.6

‐4

‐3

‐2

‐1

0

1

2

3

4

NHY1ZE

5ZW2N

9SF9898

ZM99

S98YSG

8MQOOCT

8Z8YS9F

6306WG

FIKSPK

EBQAX

YLLLSLL

SGDY

90YYDE

DD

8ZZZO7

I9MZ11

888Z8S

DYEYYG

DQED

DN2H

9171

HCW

3AW

KX18

KOLYWXR

6AG

NIZI

D5BV

EIIOP7

DSNU06C7

3UMO3Y

28YA

CH1SAE

BM20LM

ZFV3

BKMA

NNBN

TNULXUTD

HCZG6T

I3W3SW

EDRLTN

ANHV

ML

VJMKC

EGEZZ2P

IJ37J2

MRW

DWG

0J0PYS

0LN2Q

EDN

KLDD

Q8ECTW

TLVU

3EKYGWUS

J1X7S4

BPLP0L

OLLRLR

XL5KA0

8GORY

Y3V

0OFD

DQMISD

OGLN

KIQIEBZ

BIM

8WG1

NSJNGB

DFCX

DG0R

E0L0

V43U

FLHYEPEU

KN4P

SKFO

8JOE

VZSIJV

IRIBPI

H74EH

5RJXP

PPK2

D2PO

PF5IJN

555YH5

DLDL

OB

7WPIJX

666F66

XVDW

7XAE

E5WA

HYR

H0O

YCYB

YWEM

ZZIW

ET1YHT

XH2D

7FIM

EQDK

IT3X

HS

‐17.5

‐16.4

‐14.5

‐9.4

5.8

4.1





57

crean

Sticky Note

Marked set by crean


Code Identified Substances0J0PYS ketamine

0LN2QE Ketamine

0N05YR ketamine

0RE0L0 ketamine, lactose

1SAEBM ketamine

20LMZF Ketamine

28YACH Ketamine

33HOOD Ketamine

3BY3P6 Ketamine

3MGTTL ketamine

3RV3F7 ketamine

3UMO3Y ketamine

3V0OFD ketamine

4FA8F0 Ketamine

555YH5 Ketamine

5V22WM Ketamine

5WSWTT -

5ZW2N9 ketamine

6306WG ketamine

666F66 ketamine

7FH7HV Kétamine

7K1RKK Ketamine

7WPIJX ketamine

888Z8S Ketamine

8GORYY Ketamine

8SVPRT Ketamine

8YSG8M ketamine

8ZZZO7 ketamine

A3AH32 Ketamina

AIPPIG Ketamine

AJ22ZI ketamine

AKJ5JY Ketamine

ANHVML Ketamine

BLZZMB ketamine

BPLP0L ketamine

C9TTRY ketamine

CWLQJ1 Ketamine

CZV766 Ketamine

D5BVEI Ketamine

D8DHQW Ketamine

Sample 3 Analysis



58

Code Identified SubstancesDFCXDG Ketamine

DLDLOB Ketamine

DNKLDD Ketamine

DQMISD ketamine

DYEYYG Ketamine

EBQAXY Kétamine

EDRLTN Ketamine

ELN44T Ketamine

EMZZIW ketamine

ET1YHT Ketamine

FFFAFF ketamine

FIKSPK Ketamine

FL6M38 Ketamine

FO8JOE ketamine

GCGWXG Ketamine

GEZZ2P Ketamine

GK8FTC ketamine

H4TJQT chlormezanone

H74EH5 Ketamine hcl

HCW3AW Ketamine HCl

HCZG6T Ketamine

HYEPEU Ketamine

HYRH0O Ketamine

I3W3SW KETAMINE

I9MZ11 Ketamine

IJ37J2 Ketamine

IM8WG1 Ketamine

IMEQDK Ketamine

IOP7DS Ketamine

IRIBPI ketamine

IT3XHS ketamine

J1X7S4 Ketamine HCl

JA3JJQ Ketamine

JIRDRI Ketamine

K2D2PO Ketamine

KEANRN Ketamine

KGJIJS Ketamine

KN4PSK Ketamine

KPAKKD Ketamine

KX18KO Ketamine

KYGWUS Ketamine

LG45WT Ketamine

LLLSLL ketamine

LYWXR6 Ketamine



59

Code Identified SubstancesM1Q1F5 Ketamine

MJHGVG KETAMINE

MRWDWG ketamine

NBI4J4 ketamine and lactose

NHY1ZE Ketamine

NNBNTN ketamine

NSJNGB Ketamine

NU06C7 Ketamine

NVENEN Ketamine

O2WSYF ketamine

OGLNKI Ketamine

OLLRLR ketamine

ORHNDM kétamine chlorhydrate

OW2RIV Ketamine

PIRHNH ketamine

PPHBGP KETAMINE

PSQS7F KETAMINE

Q11YO1 ketamine

Q8ECTW ketamine

QIEBZB Ketamine

QOOCT8 Ketamine

QTTSCI Ketamine

RJXPPP Ketamine

RV9IZA Ketamine

RXKBFM ketamina

S4B5OL Ketamine and Lactose

SAZ3ZW Ketamina

SF9898 Ketamine

SUOIOI Ketamine

TIILNU Ketamine

TLVU3E Ketamine

U54UUY N/A

UIIF4G Ketamina

ULQHBK Ketamine

ULXUTD ketamine

V3BKMA Ketamine

V43UFL Ketamine

VGVOLX Ketamine and Lactose

VJMKCE Ketamine

VLJXIU Ketamine

VLLLV0 ketamina

VMHH2Y Ketamine

VXXFXK ketamine

VZSIJV ketamine



60

Code Identified SubstancesW33NYG Ketamine

XFPUFJ ketamine

XGELS2 Ketamine

XH2D7F ketamine

XL5KA0 Ketamine

XMAYN4 ketamine

XVDW7X Ketamine

YCYBYW Ketamine

YVAVK8 ketamine

YWZYAR ketamine

YYDEDD Ketamine

Z154TB ketamine

Z8YS9F Ketamine

ZM99S9 Ketamine

ZZKXPP KETAMINE



61

Code Ketamine Lactose

0J0PYS + +

Sample three contains ketamine,HCL (16.6% as base) cut with lactose

0LN2QE + +

Contained Ketamine and lactose

0N05YR + ANP

resolution 1478 de 2006. Incluided Ministerio de Salud y Protección Social/ Colombia

0RE0L0 + +

The ketamine is scheduled as illicit drug in France. The lactose is not scheduled as illicit drug in France. It's a cutting agent.

1SAEBM + +

Sample contains 16.31± 0.92 % (w/w) ketamine base.The sample also contains lactose.

20LMZF + +

One glass bottle containing 0.22 grammes of a powder containing 0.03 grammes of ketamine.

28YACH + ANP

Ketamine existed in salt form. We were found Lactose in the sample.

2H9171 + +

33HOOD + ANP

Based on the above analysis, the sample was found to contain ketamine

3BY3P6 + +

3MGTTL + ANP

3RV3F7 + +

in the sample are ketamine and lactose who is not on the list in Montenegro

3UMO3Y + +

white powder, diluted by lactose

3V0OFD + +

white powder containing 15.1% ketamine. Contains also lactose.

4FA8F0 + +

Ketamine, Lactose

555YH5 + -

5V22WM + +

The powder was analysed and found to contain Ketamine.

5WSWTT ANP +

after chemical analysis was performed, the sample was found to contain: 1. lactose. 2. no controlled drugs.

5ZW2N9 + ANP

ketamine was detected by GC/MS screening and it was confirmed and quantified by GC-FID using calibration curve

6306WG + -

666F66 + -

ketamine

7FH7HV + -

l'analyse de l'échantillon 2014/1/SM-3 révèle la présence de la kétamine




62


7K1RKK + ANP

A sample of the powder was analysed and found to contain Ketamine at a concentration of 14% , which is a class B controlled substance under the Misuse of Drugs Act 1971

7WPIJX + +

+lactose

888Z8S + ANP

On analysis, I found the substance to contain 22.5% Ketamine

8GORYY + +

The sample contains ketamine which is listed as a controlled drug according to french order, appendix IV of February 22nd 1990.

8SVPRT + ANP

The peak of IR of test sample was same as ketamine

8YSG8M + ANP

found ketamine with 21.3% w/w

8ZZZO7 + -

On analysis, I found the sustances to contain 17.99% (by weight) of ketamine

A3AH32 + ANP

ketamina

AEE5WA + +

Ketamine and Lactose

AGNIZI + +

mixture of ketamine and lactose

AIPPIG + ANP

White powder containing Ketamine.

AJ22ZI + ANP

The sample was found to contain ketamine

AKJ5JY + ANP

Sample 2014/1/SM-3, a white, odourless powder, gave a positive result for Ketamine, a controlled substance under national legislation on drugs.

ANHVML + +

White powder containing ketamine. Ketamine seized prior to 10th June 2014 is a Class C controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended). Ketamine seized on or after 10th June 2014 is a Class B controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended).

BLZZMB + +

lactose

BPLP0L + +

This sample is ketamine

C9TTRY - -

CWGDML + +

Ketamine was detected on Sample SM-3, this drug is not controlled by national legislation in Costa Rica. Ketamine it is not included on United Nations lists.

CWLQJ1 + -

The coincidence in the time of retention and mass fragmentogram with the material reference used in the same conditions that the analyzed sample, they indicates in this one the ketamine's presence.

CZV766 + ANP

The white powder contains Ketamine.

D5BVEI + ANP

Powder containing ketamine.



63


D8DHQW + +

Ketamine, a prohibited substance included in the National Law for Narcotics, is found to be present in this sample.

DFCXDG + +

The sample contains ketamine 17.48 %, m/m.

DLDLOB + ANP

narcotics: ketamineconcentration: approx 16 % as free base

DNKLDD + ANP

DQEDDN + +

DQMISD + +

powder with 17,0 % of ketamine as a active substance and lactose as a adulterant

DYEYYG + +

Ketamine and lactose

EBQAXY + -

The sample 2014/1/SM-3 contains ketamine.Ketamine is a controlled substance in France

EDRLTN + +

The exhibit item was found to contain Ketamine

ELN44T + ANP

On analysis, I found the sample to contain ketamine

EMZZIW + -

ET1YHT + ANP

17.8 % Ketamine

FFFAFF + ANP

White powder that contains substance ketamine.

FIKSPK + ANP

It has been detecded that tehe subject of study including White colour dust substance was Ketamine. This is a drug which is under the terms of national sunstance of drug Law 2313.

FL6M38 + -

polvo cristalino blanco

FO8JOE + +

Ketamine retention time and MS spectra in GC analysis (FID and MS) compared with ICE reference material. Cloudy CHCl3 solution and FTIR/ATR indicates a mixture with lactose (confirmation performed by FTIR). Ketamine as hydrochloride.

G222HF ANP ANP

GCGWXG + +

Ketamine is a Class C controlled drug subject to the provisions of the Misuse of Drugs Act 1971.

GEZZ2P + -

GK8FTC + ANP

H4TJQT + +

H74EH5 + +

Base Ketamine 16,0% and Lactose



64


HCW3AW + ANP

Negative with Marquis, Cobalt thiocyanate and Simon (No color change). Silver Nitrate Test--> Chloride Positive.TLC(TA,TE), GCMS --> Ketamine confirmed. GC--> Ketamine base 15.58%

HCZG6T + +

The sample was found to contain 16.0% of ketamine (as base).

HYEPEU + ANP

The powder is a psychotropic substance - ketamine powder. Quantity of pure substance not detected.

HYRH0O + -

Ketamine

I3W3SW + +

KETAMINE IS PRESENT IN HYDROCHLORIDE FORM. LACTOSE WAS ALSO IDENTIFIED.

I9MZ11 + +

SM-3 contained Ketamine

IJ37J2 + -

In the test sample 2014/1/SM-3 was detected Ketamine

IM8WG1 + ANP

IMEQDK + ANP

We have identified the drug, but we are unable to quantify it because we do not have Ketamine certified reference.

IOP7DS + ANP

The sample contains ketamine (15.5%).

IRIBPI + +

We also found lactose

IT3XHS + -

Viloet color in cobalt Thiocyanate test indicates possible presence of Ketamine.Rf and color of std Ketamine equal to those of SM3.Retention Time(RT 13.129) and base peaks 180 of SM3 are mostly identical to those of std Ketamine and library search in GCMS shows SM3 being Ketamine.

J1X7S4 + +

SM3 contains also Lactose.

JA3JJQ + +

Ketamine and lactose

JIRDRI + ANP

Ketamine positive

K2D2PO + ANP

We have used only GC/MS as screening and identification.

KEANRN + ANP

In the tested sample was detected and confirmed the presence of Ketamine

KGJIJS + -

SIGN IN DETECTED 2014/1/SM-2 labeled Ketamine.

KN4PSK + -

Ketamine

KPAKKD + ANP

The sample contains Ketamine

KX18KO + +

White powder containing ketamine which is a class B controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended). The results also indicated the presence of lactose which is not subject to control under the provisions of the Misuse of Drugs Act 1971 (as amended).



65


KYGWUS + ANP

0.236 grams of off-white powder found to contain Ketamine. At the time of seizure Ketamine was controlled by the Misuse of Drugs Act 1971 (as amended) as a Class C drug. Since 10th June 2014, Ketamine has been controlled by the Misuse of Drugs Act 1971 as amended), as a Class B drug.

LG45WT + ANP

The sample was soluble in water, ethanol, methanol and chlorofom.The sample had positive reaction for alkaloid with tanred reagent .The sample had positive reaction for chlorides with silver nitrate reagent .

LLLSLL + +

additional substance - lactose

LYWXR6 + ANP

Ketamine is under illicit drugs legislation control in Spain since 2010.

M1Q1F5 + ANP

The sample contain controled drug ketamine

MJHGVG + +

hydrochloride form + lactose

MRWDWG + ANP

white powder containing 17.1%mM7 of ketamine

NBI4J4 + +

NHY1ZE + -

SM3 was contain dissociative anesthetic (Ketamine)

NNBNTN + +

Ketamine and lactose confirmed in one unit tested of one unit recieved.

NSJNGB + -

Ketamine

NU06C7 + -

NVENEN + ANP

The Sample 2014/1/SM3 was found to contain Ketamine.

O2WSYF + +

The sample is a preparation that contains ketamine and lactose.

OGLNKI + -

Ketamine

OLLRLR + ANP

the white powder contains ketamine (17.8%w/w), which is controlled bt national law

ORHNDM + +

kétamine, substance classée stupéfiant

OW2RIV + ANP

Sample containing Ketamine

PF5IJN + +

MARQUIS, SCOTT, SIMON´S, UV, HPLC, GC-MS, FT-IR

PIRHNH + +



66


PPHBGP + -

The results of the tests of the SM3 () received confirmed that the mentioned sample contains KETAMINE butwe are not able to give a cuantification result because we can not do it with our gas chromatography-gasspectometer and we have not got a gas chromatography FID which is the suitable analytical technique.

PSQS7F + -

The simple No 2014/1/SM-2 was found KETAMINE

Q11YO1 + ANP

white powder containing ketamine

Q8ECTW + +

The powder is a mixture of ketamine and lactose. The concentration of ketamine in the sample is 16.9% by weight

QIEBZB + ANP

The substance contains 16.27% of Ketamine

QOOCT8 + ANP

Sample 2014/1/SM-2 was found to contain Ketamine.

QTTSCI + ANP

Examination of the powder SM-3 revealed the presence of controlled drug Ketamine

RJXPPP + ANP

RV9IZA + ANP

RXKBFM + +

S4B5OL + +

The test sample 2014/1/SM-3 was analysed by colour test and Thin layer Chromatography (TLC) techniques and found to contain Ketamine and Lactose.

SAZ3ZW + -

De acuerdo a los análisis realizados se concluye que se trata Ketamina

SF9898 + +

Ketamine was identified by TLC and GC/MS

SGDY90 + -

SUOIOI + ANP

I made the chemical and instrumental analysis it resulted that the sample contains ketamine

TIILNU + +

Also contain Lactose

TLVU3E + +

The sample SM3 contained 16.8 % ketamine calculated as a base. In the sample was identified lactose.

U54UUY - +

The sample tested positive for Lactose using TLC with two (2) solvent systems. The sample could have been an adulterant used in seized materials (SM).

UIIF4G + +

ULQHBK + -

2014/1/SM-3 contains Ketamine.



67


ULXUTD + -

lactose

V3BKMA + ANP

V43UFL + +

lactose

VGVOLX + +

CT reagent: positive. GC/MS: Retention time, mass-charge (M/Z) similar characteristics with the substances used as standar or pattern. FTIR: Absorption bands conicident with the substances used as pattern

VJMKCE + +

A white powder containing KETAMINE

VLJXIU + +

Was found too LACTOSE

VLLLV0 + ANP

VMHH2Y + +

VXXFXK + +

lactose

VZSIJV + ANP

ketamine is controlled (KB 22/01/1998)

W33NYG + ANP

Analyzing the results obtained by the three tests cited above we have come to the conclusion that we are in the presence of a drug bids the KETAMINE.

XFPUFJ + ANP

XGELS2 + +

XH2D7F + +


XL5KA0 + +

Presence of ketamine hydrochloride and lactose was detected in the sample.

XMAYN4 + +

*Retention time and fragmentation patterns obtained with sample are equivalent to those obtained with ketamine. *Spectroscopic parameters obtained with sample are equivalent to those obtained with lactose.

XVDW7X + ANP

The sample SM-3 contains ketamine, which is included in List C1 (List of other substances under special control) of Annex I of SVS / MS 344, May 12, 1998.

YCYBYW + -

YVAVK8 + +

lactose

YWZYAR + +

lactose

YYDEDD + -

Z154TB + +

The sample contain lactose



68


Z8YS9F + ANP

ZM99S9 + ANP

The sample obtains with the positive result with Marquis reagent.TLC : The Rf sample obtain with the same Rf Ketamine standard.GC: The Rt sample obtain with the same Rt Ketamine standard.

ZZKXPP + ANP

CONFIRMED BY GC MS



69


Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

0J0PYS S I I

0LN2QE I SI I

0N05YR S I I

0RE0L0 S S I I

1SAEBM S I I SI SI

20LMZF S S SI I

28YACH S I I

2H9171 SI

33HOOD S I

3BY3P6 S S S I I

3MGTTL I S

3RV3F7 S I I I

3UMO3Y SI I

3V0OFD I SI

4FA8F0 I I SI I


5V22WM S S I I

5WSWTT S S I I I

5ZW2N9 I SI

6306WG SI SI I I

666F66 SI SI SI I I

7FH7HV S I


7WPIJX S I I

888Z8S S S I

8GORYY I I

8SVPRT I SI

8YSG8M SI

8ZZZO7 S S S I

A3AH32 S S S I I

AEE5WA SI I

AGNIZI SI I I SI

AIPPIG S I SI SI I

AJ22ZI S I





70

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

AKJ5JY S S I I

ANHVML S S I I

BLZZMB S I SI SI

BPLP0L S I I

C9TTRY S S S I

CWGDML S S I I S

CWLQJ1 S S I

CZV766 S S S SI

D5BVEI SI

D8DHQW SI S I I I

DFCXDG I SI I LC/RI

DLDLOB SI I GC-IRD

DNKLDD I SI

DQEDDN SI I

DQMISD SI I

DYEYYG S I

EBQAXY SI

EDRLTN I SI

ELN44T I SI

EMZZIW I SI



FIKSPK S I I

FL6M38 S S S I SI

FO8JOE I I I SI

G222HF S S I SI

GCGWXG S S I I

GEZZ2P S I

GK8FTC I SI FPIA


H74EH5 S I I I XRD

HCW3AW S S S I I

HCZG6T SI

HYEPEU S S I I

HYRH0O I SI

I3W3SW I SI

I9MZ11 S S I I I

IJ37J2 I

IM8WG1 S S SI SI



71

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

IMEQDK S S I

IOP7DS S S S I I

IRIBPI SI I


J1X7S4 I S I I

JA3JJQ S I I

JIRDRI I SI


KEANRN S SI SI

KGJIJS S S S I

KN4PSK I SI

KPAKKD SI

KX18KO S S S I I

KYGWUS S S I

LG45WT S S S I

LLLSLL I SI ATR

LYWXR6 I SI

M1Q1F5 SI ASAP-TOF

MJHGVG SI

MRWDWG

I SI

NBI4J4 SI S I I

NHY1ZE S SI I SI

NNBNTN SI I I I CE

NSJNGB I SI


NVENEN S S S I I

O2WSYF I S I

OGLNKI SI

OLLRLR I SI

ORHNDM I SI I

OW2RIV SI I

PF5IJN S S S I I I

PIRHNH S I I

PPHBGP SI SI SI I

PSQS7F SI I

Q11YO1 SI



QOOCT8 S I



72

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

QTTSCI S SI

RJXPPP SI I

RV9IZA S SI


S4B5OL S S SI I A


SF9898 S S S I I

SGDY90 I I SI

SUOIOI S I

TIILNU S I I

TLVU3E I I


UIIF4G S I I

ULQHBK S S S I I

ULXUTD S I

V3BKMA S I I

V43UFL SI

VGVOLX S S I I

VJMKCE S S S I I

VLJXIU S S I I

VLLLV0 S S I

VMHH2Y I SI

VXXFXK S I SI SI

VZSIJV I S

W33NYG S S S I I

XFPUFJ I

XGELS2 I SI SI

XH2D7F I I


XMAYN4 S S S I I

XVDW7X S S S I

YCYBYW SI

YVAVK8 S I SI SI

YWZYAR SI SI

YYDEDD SI I

Z154TB S I SI SI

Z8YS9F SI

ZM99S9 S S S I I

ZZKXPP SI I



73







Code Name Technique

141 160


PF5IJN Cocaine 180/190

H4TJQT Chlormezanone 150/160/161/180

Section 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

Screening 52 63 50 14 0 2 0 3 57 16 3 0 0 0 9

34.4% 41.7% 33.1% 9.3% 0.0% 1.3% 0.0% 2.0% 37.7% 10.6% 2.0% 0.0% 0.0% 0.0% 6.0%

Identification 11 3 2 40 6 13 2 26 135 56 3 2 2 1 13

7.3% 2.0% 1.3% 26.5% 4.0% 8.6% 1.3% 17.2% 89.4% 37.1% 2.0% 1.3% 1.3% 0.7% 8.6%


55 63 50 47 6 14 2 27 135 59 4 2 2 1 18

36.4% 41.7% 33.1% 31.1% 4.0% 9.3% 1.3% 17.9% 89.4% 39.1% 2.6% 1.3% 1.3% 0.7% 11.9%



Code: U54UUY (150/161), 5WSWTT (ANP), G222HF (ANP)


Ketamine: 147

74






averagez-score



averagez-score

0J0PYS 16.6 0.1 0.0 HYRH0O 20.2 3.7 2.10LN2QE 15.6 -0.9 -0.5 I9MZ11 20.3 3.8 2.11SAEBM 16.3 -0.2 -0.1 IJ37J2 16.0 -0.5 -0.320LMZF 14.7 -1.8 -1.0 IM8WG1 14.7 -1.8 -1.028YACH 17.0 0.5 0.3 IOP7DS 15.5 -1.0 -0.62H9171 16.3 -0.2 -0.1 IRIBPI 14.4 -2.1 -1.23MGTTL 20.9 4.4 2.5 IT3XHS 9.2 -7.3 -4.23UMO3Y 16.3 -0.2 -0.1 J1X7S4 16.7 0.2 0.13V0OFD 15.1 -1.4 -0.8 KN4PSK 16.5 0.0 0.0555YH5 6.9 -9.6 -5.5 LYWXR6 14.7 -1.8 -1.05ZW2N9 19.1 2.6 1.5 MRWDWG 17.1 0.6 0.36306WG 14.4 -2.1 -1.2 NHY1ZE 9.0 -7.5 -4.37K1RKK 14.0 -2.5 -1.4 NNBNTN 15.9 -0.6 -0.47WPIJX 21.0 4.5 2.5 NSJNGB 16.8 0.3 0.2888Z8S 22.5 6.0 3.4 OGLNKI 15.8 -0.7 -0.48GORYY 18.0 1.5 0.8 OLLRLR 17.8 1.3 0.78SVPRT 15.2 -1.3 -0.8 PF5IJN 10.7 -5.8 -3.38YSG8M 21.3 4.8 2.7 Q8ECTW 16.9 0.4 0.28ZZZO7 18.0 1.5 0.8 QIEBZB 16.3 -0.2 -0.1AGNIZI 17.0 0.5 0.3 QOOCT8 16.0 -0.5 -0.3BPLP0L 15.4 -1.1 -0.6 RJXPPP 17.0 0.5 0.3DFCXDG 17.5 1.0 0.5 SF9898 12.9 -3.6 -2.1DLDLOB 15.8 -0.7 -0.4 SGDY90 15.0 -1.5 -0.9DNKLDD 15.9 -0.6 -0.4 TLVU3E 16.2 -0.3 -0.2DQEDDN 9.4 -7.1 -4.1 ULXUTD 16.5 0.0 0.0DQMISD 17.0 0.5 0.3 V3BKMA 17.0 0.5 0.3EDRLTN 14.6 -1.9 -1.1 VZSIJV 16.6 0.1 0.0EMZZIW 20.0 3.5 2.0 XH2D7F 21.0 4.5 2.5ET1YHT 17.8 1.3 0.7 XL5KA0 16.9 0.4 0.2FIKSPK 24.0 7.5 4.2 XVDW7X 18.8 2.3 1.3FO8JOE 16.7 0.2 0.1 YWZYAR 27.0 10.5 5.9GEZZ2P 31.4 14.9 8.4 YYDEDD 17.1 0.6 0.3H74EH5 16.0 -0.5 -0.3 Z8YS9F 16.3 -0.2 -0.1

HCW3AW 15.6 -0.9 -0.5 ZM99S9 19.7 3.2 1.8HCZG6T 16.0 -0.5 -0.3

Code

Ketamine

Code

Ketamine

75

Substance: SM-3/Ketamine

Round: 2014/1


.Robust average = 16.5UNODC value = 16.1

‐3.3

‐2.1

‐1.4 ‐1.2

‐1.2 ‐1.1 ‐1.0

‐1.0

‐1.0 ‐0.9 ‐0.8 ‐0.8 ‐0.6 ‐0.6 ‐0.5

‐0.5 ‐0.4

‐0.4 ‐0.4

‐0.4 ‐0.3

‐0.3

‐0.3

‐0.3 ‐0.2

‐0.1

‐0.1

‐0.1

‐0.1

‐0.1 0.0

0.0

0.0

0.0 0.1

0.1 0.2 0.2

0.2 0.3

0.3

0.3

0.3

0.3 0.3

0.3 0.5 0.7

0.7 0.8

0.8

1.3 1.5

1.8 2.0 2.1 2.1

2.5 2.5

2.5 2.7

3.4

‐4.0

‐3.0

‐2.0

‐1.0

0.0

1.0

2.0

3.0

4.0

555YH5

NHY

1ZE

IT3X

HS

DQED

DN

PF5IJN

SF98

98

7K1R

KK

6306

WG

IRIBPI

EDRLTN

LYWXR

6

20LM

ZF

IM8W

G1

SGDY

90

3V0O

FD

8SVP

RT

BPLP0L

IOP7

DS

HCW3A

W

0LN2Q

E

OGLN

KI

DLDL

OB

DNKLDD

NNBN

TN

HCZG6T

H74EH5

QOOCT

8

IJ37J2

TLVU

3E

QIEBZ

B

1SAE

BM

3UMO3Y

2H9171

Z8YS9F

KN4P

SK

ULXUTD

VZSIJV

0J0P

YS

J1X7

S4

FO8JOE

NSJNGB

Q8ECTW

XL5K

A0

RJXP

PP

V3BK

MA

DQMISD

28YA

CH

AGNIZI

YYDE

DD

MRW

DWG

DFCX

DG

OLLRLR

ET1YHT

8ZZZO7

8GORY

Y

XVDW

7X

5ZW2N

9

ZM99S9

EMZZIW

HYR

H0O

I9MZ11

3MGTTL

XH2D

7F

7WPIJX

8YSG

8M

888Z8S

FIKSPK

YWZYAR

GEZZ2P

‐5.5

‐4.3 ‐4.2

‐4.1

4.2 5.9

8..4





76


Code Identified Substances0J0PYS cocaine

0LN2QE Cocaine

0N05YR Cocaine

0RE0L0 cocaine

1SAEBM cocaine

20LMZF Cocaine

28YACH Cocaine

33HOOD Cocaine

3BY3P6 Cocaine

3MGTTL cocaine

3RV3F7 cocaine

3UMO3Y cocaine

3V0OFD cocaine

4FA8F0 Cocaine

555YH5 Cocaine

5V22WM Cocaine Hydrochloride

5WSWTT cocaine.

5ZW2N9 cocaine

6306WG cocaine

666F66 cocaine

7FH7HV Cocaïne et MDMA

7K1RKK Cocaine

7WPIJX cocaine

888Z8S Cocaine

8GORYY Cocaine

8SVPRT Cocaine

8YSG8M cocaine

8ZZZO7 cocaine

A3AH32 Cocaina

AEE5WA Cocaine

AGNIZI cocaine

AIPPIG Cocaine

AJ22ZI cocaine

AKJ5JY Cocaine

ANHVML Cocaine

BLZZMB cocaine

BPLP0L cocaine

C9TTRY cocaine

CWGDML Cocaine hydrochloride

CWLQJ1 Cocaine

Sample 4 Analysis



77

Code Identified SubstancesCZV766 Cocaine

D5BVEI Cocaine

D8DHQW Cocaine

DFCXDG Cocaine

DLDLOB Cocaine

DNKLDD Cocaine

DQMISD cocaine

DYEYYG Cocaine

EBQAXY Cocaïne

EDRLTN Cocaine

ELN44T Cocaine

EMZZIW cocaine

ET1YHT Cocaine

FFFAFF cocaine

FIKSPK Cocaine

FL6M38 Cocaine

FO8JOE cocaine

GCGWXG Cocaine hydrochloride

GEZZ2P Cocaine

GK8FTC cocaine

H74EH5 Cocaine hcl

HCW3AW Cocaine HCl

HCZG6T Cocaine

HYEPEU Cocaine

HYRH0O Cocaine

I3W3SW COCAINE

I9MZ11 Cocaine

IJ37J2 Cocaine

IM8WG1 Cocaine

IMEQDK Cocaine

IOP7DS Cocaine

IRIBPI cocaine

IT3XHS cocaine

J1X7S4 Cocaine HCl

JA3JJQ Cocaine

JIRDRI Cocaine

K2D2PO cocaine

KEANRN Cocaine

KGJIJS COCAINE

KN4PSK Cocaine

KPAKKD Cocaine

KX18KO Cocaine Hydrochloride

KYGWUS Cocaine

LG45WT Cocaine



78

Code Identified SubstancesLLLSLL cocaine HCl

LYWXR6 Cocaine

M1Q1F5 Cocaine

MJHGVG COCAIN

MRWDWG cocaine

NBI4J4 cocaine

NHY1ZE Cocaine

NNBNTN cocaine hydrochloride

NSJNGB Cocaine

NU06C7 Cocaine 76,8%

NVENEN Cocaine

O2WSYF cocaine

OGLNKI Cocaine

OLLRLR cocaine

ORHNDM cocaine chlorhydrate

OW2RIV Cocaine

PF5IJN COCAÍNA

PIRHNH cocaine

PPHBGP COCAÍNE

PSQS7F COCAINE

Q11YO1 cocaine

Q8ECTW cocaine

QIEBZB Cocaine

QOOCT8 Cocaine

QTTSCI Cocaine

RJXPPP Cocaine

RV9IZA Cocaine

RXKBFM cocaina

S4B5OL Cocaine

SAZ3ZW Cocaína clorhidrato

SF9898 Cocaine

SUOIOI Cocaine

TIILNU Cocaine

TLVU3E Cocaine

U54UUY COCAINE

UIIF4G Cocaina

ULQHBK Cocaine

ULXUTD cocaine

V3BKMA Cocaine

V43UFL cocaine, HCl

VGVOLX Cocaine

VJMKCE Cocaine Hydrochloride

VLJXIU COCAINE

VLLLV0 cocaina



79

Code Identified SubstancesVMHH2Y Cocaine

VXXFXK cocaine

VZSIJV cocaine

W33NYG Cocaine

XFPUFJ cocaine

XGELS2 Cocaïne

XH2D7F cocaine

XL5KA0 Cocaine

XMAYN4 cocaine

XVDW7X Cocaine

YCYBYW Cocaine

YVAVK8 cocaine

YWZYAR cocaine

YYDEDD Cocaine

Z154TB cocaine

Z8YS9F Cocaine

ZM99S9 Cocaine

ZZKXPP COCAINE



80

Code Cocaine

0J0PYS +

Sample four contains cocaine,HCL (83.5% as base)

0LN2QE +

Contained cocaine and cinnamoylcocaine, methylecgonine, methylecgonidine

0N05YR +

Different procedures were performed to the sample. Starting with colorimetric reactions, after confirmation instrumental analysis using GC-MS and GC-FID. Finally simple was quantified using GC-FID

0RE0L0 +

The sample contains cocaine which is scheduled as illicit drug in France.

1SAEBM +

Sample contains 78.9± 3.2 % (w/w) cocaine base in HCL salt form.

20LMZF +

One glass bottle containing 0.22 grammes of a solid containing 0.17 grammes of cocaine.

28YACH +

Cocaine existed in salt form. Were found Ergonine-methyl-ester and Benzoylergonine in the sample.

2H9171 +

33HOOD +

Based on the above analysis, the sample was found to contain cocaine.

3BY3P6 +

White substance contains Cocaine

3MGTTL +

3RV3F7 +

in the sample is cocaine who is on the list of drugs in Montenegro

3UMO3Y +

white powder, also contain typical "natural" impurities, ethyl benzoate, ecgonidine methylester ecgonine methylester, norcocaine and cinnamoylcocaine (cis and trans isomers)

3V0OFD +

white powder containing 72.0% cocaine

4FA8F0 +

Cocaine, caffeine

555YH5 +

5V22WM +

The powder was analysed and found to contain Cociane Hydrochloride.

5WSWTT +

after chemical analysis was performed, the sample was found to contain89.5 cocaine.

5ZW2N9 +

cocaine was detected by GC/MS screening and it was confirmed and quantified by GC-FID using calibration curve

6306WG +

666F66 +

cocaine




81

Code Cocaine

7FH7HV +

Après analyse, l'échantillon 2014/1/SM-4 contient de la cocaïne et du MDMA

7K1RKK +

A sample of the powder was analysed and found to contain Cocaine at a concentration of 79%, which is a class A controlled substance under the Misuse of Drugs Act 1971

7WPIJX +

888Z8S +

On analysis, I found the substance to contain Cocaine.

8GORYY +

The sample contains cocaine which is listed as a controlled drug according to french order, appendix I of February 22nd 1990.

8SVPRT +

The result of TLC and IR of test sample was same as cocaine

8YSG8M +

found cocaine with 78.3%w/w

8ZZZO7 +

On analysis, I found the sustances to contain 75.23% (by weight) of cocaine

A3AH32 +

Cocaina

AEE5WA +

AGNIZI +

mixture of cocaine and lactose

AIPPIG +

Off-white powder containing cocaine.

AJ22ZI +

The sample was found to contain cocaine

AKJ5JY +

Sample 2014/1/SM-4, a white powder with acrid odour, gave a positive result for Cocaine, a controlled substance under national legislation on drugs.

ANHVML +

Off-white powder containing an average of 81% cocaine. Cocaine is a Class A controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended).

BLZZMB +

BPLP0L +

This sample is cocaine.

C9TTRY +

CWGDML +

CWLQJ1 +

The chemical tests and the coincidence in the time of retention and mass fragmentogram with the material reference used in the same conditions that the analyzed sample, they indicates in this one the cocaine's presence.

CZV766 +

The white powder contains Cocaine.

D5BVEI +

Powder containing cocaine



82

Code Cocaine

D8DHQW +

Cocaine, a prohibited substance included in the National Law for Narcotics, is found to be present in this sample.

DFCXDG +

The sample contains cocaine 66.34 %, m/m.

DLDLOB +

narcotics: cocaineconcentration: approx 73 % as free base

DNKLDD +

DQEDDN +

DQMISD +

powder with 80,8 % of cocaine

DYEYYG +

Cocaine

EBQAXY +

The sample 2014/1/SM-4 contains 78% of cocaïne base.Cocaïne is a controlled substance in France

EDRLTN +

The exhibit item was found to contain Cocaine

ELN44T +

On analysis, I found the sample to contain cocaine

EMZZIW +

ET1YHT +

84.4 % Cocaine

FFFAFF +

White powder that contains substance under control - cocaine.

FIKSPK +

It has been detecded that tehe subject of study including White colour dust substance was Cocaine. This is a drug which is under the terms of national sunstance of drug Law 2313.

FL6M38 +

polvo blanco is cocaine

FO8JOE +

Retention time and MS spectra in GC analysis (FID and MS) compared with ICE reference material. Cocaine as hydrochloride.

G222HF +

GCGWXG +

Cocaine is a Class A controlled drug subject to the provisions of the Misuse of Drugs Act 1971.

GEZZ2P +

GK8FTC +

H4TJQT +

benzoic acid - ecgonine methylester-benzoylecgonine

H74EH5 +

Base Cocaine 77,0%



83

Code Cocaine

HCW3AW +

Negative with Marquis and Simon. Positive with Cobalt thiocyanate. Silver Nitrate Test--> Chloride Positive.TLC(TA,TE), GCMS --> Cocaine confirmed. GC--> Cocaine base 74.83%

HCZG6T +

The sample was found to contain 77.4% of cocaine (as base).

HYEPEU +

The powder is a narcotic substance - cocaine powder. The powder contains 80.0 % pure cocaine (base form).

HYRH0O +

Cocaine, Methylecgonine

I3W3SW +

COCAINE IS PRESENT IN HYDROCHLORIDE FORM. OTHER COCA PRODUCTS WERE IDENTIFIED.

I9MZ11 +

SM-4 contained Cocaine

IJ37J2 +

In the test sample 2014/1/SM-4 was detected Cocaine

IM8WG1 +

IMEQDK +

IOP7DS +

The sample contains cocaine (74.3%).

IRIBPI +

We also found traces of methylecgonine, cinnamoyl cocaine, benzoylecgonine and norcocaine

IT3XHS +

Blue color in cobalt thiocyanate test indicates possible presence of cocaine.Rf anf colour in TLC of std Cocaine equal to those of SM4.Retention Time(RT16.4) and base Peaks of SM4( )82are mostly identical to std Cocaine and library search in GCMS also indicates SM4 being Cocaine.

J1X7S4 +

JA3JJQ +

Cocaine

JIRDRI +

Cocaine positive

K2D2PO +

KEANRN +

In the tested sample was detected and confirmed the presence of Cocaine

KGJIJS +

SIGN IN COCAINE labeled 2014/1/SM-2 DETECTED.

KN4PSK +

contained cocaine and trace of methylecgonine, methylecgonidine, cinnamoilcocaine

KPAKKD +

The sample contains Cocaine

KX18KO +

White powder containing Cocaine which is a class A controlled drug with a purity of 79% (as base) under the provisions of the Misuse of Drugs Act 1971 (as amended).



84

Code Cocaine

KYGWUS +

0.232 grams of off-white powder found to contain Cocaine at a concentration of 77%. Cocaine is controlled by the Misuse of Drugs Act 1971 (as amended) as a Class A drug.

LG45WT +

The sample has 94.9% cocaine chloride, or 84.8% cociane base

LLLSLL +

LYWXR6 +

M1Q1F5 +

The sample contain controlled drug cocaine

MJHGVG +

hydrochloride form

MRWDWG +

white powder containing 74.7%m/m of cocaine

NBI4J4 +

NHY1ZE +

SM4 was contain CNS stimulant (Cocaine).

NNBNTN +

Cocaine hydrochloride confirmed in one unit tested of one unit received.

NSJNGB +

Cocaine

NU06C7 +

NVENEN +

The Sample 2014/1/SM3 was found to contain Cocaine.

O2WSYF +

The sample is identified as cocaine.

OGLNKI +

contained cocaine and trace of methylecgonine, methylecgonidine, cinnamoilcocaine

OLLRLR +

the white powder contains cocaine (72.9%w/w), which is controlled bt national law

ORHNDM +

cocaine ,substance classée stupéfiant

OW2RIV +

Sample containing cocaine

PF5IJN ANP

MARQUIS, SCOTT, SIMON´S, SE ANALIZO Y CUANTIFICO POR UVHPLC, GC-MS, FT-IR, HPLC

PIRHNH +

PPHBGP +

The results of the tests of the SM4 () received confirmed that the mentioned sample contains COCAÍNE with48.7 percentage by weight (48.7%)

PSQS7F +

The simple No 2014/1/SM-2 was found COCAINE



85

Code Cocaine

Q11YO1 +

white powder containing 75%w/w of cocaine

Q8ECTW +

the powder is cocaine.HCl with a concentration of cocaine as base in the sample of 77.3%

QIEBZB +

The substance contains 79.39% of Cocaine

QOOCT8 +

Sample 2014/1/SM-2 was found to contain Cocaine.

QTTSCI +

Examination of the powder SM-4 revealed the presence of controlled drug cocaine

RJXPPP +

RV9IZA +

RXKBFM +

S4B5OL +

The test sample 2014/1/SM-4 was analysed by colour test and Thin layer Chromatography (TLC) techniques and found to contain Cocaine.

SAZ3ZW +

De acuerdo a los análisis realizados se concluye que se trata cocaína clorhidrato

SF9898 +

Cocaine was identified by TLC and GC/MS

SGDY90 +

SUOIOI +

made the chemical and instrumental analysis it resulted that the sample contains Cocaine

TIILNU +

The sample contains 78.9 % ± 5.7 % of Cocaine

TLVU3E +

The sample SM4 contained 77.8 % cocaine calculated as a base.

U54UUY +

Field test employing the Cobalt Thiocynate Test was positive result because the spot turned blue. TLC analysis using two(2) solvents systems and HPLC confirmed the sample as COCAINE with purity 80.23%.

UIIF4G +

ULQHBK +

2014/1/SM-4 contains Cocaine.

ULXUTD +

V3BKMA +

V43UFL +

VGVOLX +

CT reagent: positive. GC/MS: Retention time, mass-charge (M/Z) similar characteristics with the substances used as standar or pattern. FTIR: Absorption bands conicident with the substances used as pattern



86

Code Cocaine

VJMKCE +

A white powder containing an average of 87% of COCAINE HYDROCHLORIDE.

VLJXIU +

VLLLV0 +

VMHH2Y +

VXXFXK +

VZSIJV +

cocaine is controlled (KB 31/12/1930 changed by KB 8/10/1963)

W33NYG +

In this sample the three tests conducted have shown that we are in the presence of COCAINE.

XFPUFJ +

XGELS2 +

XH2D7F +


XL5KA0 +

Presence of cocaine hydrochloride was detected in the sample.The seizure also contained trace amount of cinnamoylcocaine, benzoic acid, benzoylecgonine,ecgonine methyl estar.

XMAYN4 +

*Results of screening tests were positive for cocaine. *Retention time and fragmentation pattern obtained with sample are equivalent to cocaine.

XVDW7X +

The sample SM-4 contains cocaine, which is included in List F1 (List of narcotic substances banned in Brazil) of Annex I of SVS / MS 344, May 12, 1998.

YCYBYW +

YVAVK8 +

YWZYAR +

YYDEDD +

Sample also contains benzoyl ecgonine, cis-cinnamoylcocaine, trans-cinnamoylcocaine

Z154TB +

Z8YS9F +

ZM99S9 +

The sample obtains with the positive result with Cobalt thiocyanate reagent.TLC : The Rf sample obtain with the same Rf Cocaine standard.GC: The Rt sample obtain with the same Rt Cocaine standard.

ZZKXPP +

CONFIRMED BY GC/MS



87


Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

0J0PYS S I I

0LN2QE I SI I

0N05YR S I I

0RE0L0 S S I I

1SAEBM S I I SI SI

20LMZF S S SI I

28YACH S I I

2H9171 SI

33HOOD S I

3BY3P6 S S S I I

3MGTTL I S

3RV3F7 S I I I

3UMO3Y SI I

3V0OFD I SI

4FA8F0 I I SI I


5V22WM S S I I

5WSWTT S S I I I

5ZW2N9 I SI

6306WG SI SI I I

666F66 SI SI SI I I

7FH7HV S I


7WPIJX S I I

888Z8S S S I

8GORYY I I

8SVPRT I SI

8YSG8M SI

8ZZZO7 S S S I

A3AH32 S S S I I

AEE5WA SI I

AGNIZI SI I I SI

AIPPIG S I SI SI I

AJ22ZI S I





88

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

AKJ5JY S S I I

ANHVML S S I I

BLZZMB S I SI SI

BPLP0L S I I

C9TTRY S S S I

CWGDML S S I I S

CWLQJ1 S S I

CZV766 S S S SI

D5BVEI SI

D8DHQW SI S I I I

DFCXDG I SI I LC/RI

DLDLOB SI I GC-IRD

DNKLDD I SI

DQEDDN SI I

DQMISD SI I

DYEYYG S I

EBQAXY SI

EDRLTN I SI

ELN44T I SI

EMZZIW I SI



FIKSPK S I I

FL6M38 S S S I SI

FO8JOE I I I SI

G222HF S S I SI

GCGWXG S S I I

GEZZ2P S I

GK8FTC I SI FPIA


H74EH5 S I I I XRD

HCW3AW S S S I I

HCZG6T SI

HYEPEU S S I I

HYRH0O I SI

I3W3SW I SI

I9MZ11 S S I I I

IJ37J2 I

IM8WG1 S S SI SI



89

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

IMEQDK S S I

IOP7DS S S S I I

IRIBPI SI I


J1X7S4 I S I I

JA3JJQ S I I

JIRDRI I SI


KEANRN S SI SI

KGJIJS S S S I

KN4PSK I SI

KPAKKD SI

KX18KO S S S I I

KYGWUS S S I

LG45WT S S S I

LLLSLL I SI ATR

LYWXR6 I SI

M1Q1F5 SI ASAP-TOF

MJHGVG SI

MRWDWG

I SI

NBI4J4 SI S I I

NHY1ZE S SI I SI

NNBNTN SI I I I CE

NSJNGB I SI


NVENEN S S S I I

O2WSYF I S I

OGLNKI SI

OLLRLR I SI

ORHNDM I SI I

OW2RIV SI I

PF5IJN S S S I I I

PIRHNH S I I

PPHBGP SI SI SI I

PSQS7F SI I

Q11YO1 SI



QOOCT8 S I



90

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

QTTSCI S SI

RJXPPP SI I

RV9IZA S SI


S4B5OL S S SI I A


SF9898 S S S I I

SGDY90 I I SI

SUOIOI S I

TIILNU S I I

TLVU3E I I


UIIF4G S I I

ULQHBK S S S I I

ULXUTD S I

V3BKMA S I I

V43UFL SI

VGVOLX S S I I

VJMKCE S S S I I

VLJXIU S S I I

VLLLV0 S S I

VMHH2Y I SI

VXXFXK S I SI SI

VZSIJV I S

W33NYG S S S I I

XFPUFJ I

XGELS2 I SI SI

XH2D7F I I


XMAYN4 S S S I I

XVDW7X S S S I

YCYBYW SI

YVAVK8 S I SI SI

YWZYAR SI SI

YYDEDD SI I

Z154TB S I SI SI

Z8YS9F SI

ZM99S9 S S S I I

ZZKXPP SI I



91







Code Name Technique

141 160


7FH7HV MDMA 150

Section 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210

Screening 52 63 50 14 0 2 0 3 57 16 3 0 0 0 9

34.4% 41.7% 33.1% 9.3% 0.0% 1.3% 0.0% 2.0% 37.7% 10.6% 2.0% 0.0% 0.0% 0.0% 6.0%

Identification 11 3 2 40 6 13 2 26 135 56 3 2 2 1 13

7.3% 2.0% 1.3% 26.5% 4.0% 8.6% 1.3% 17.2% 89.4% 37.1% 2.0% 1.3% 1.3% 0.7% 8.6%


55 63 50 47 6 14 2 27 135 59 4 2 2 1 18

36.4% 41.7% 33.1% 31.1% 4.0% 9.3% 1.3% 17.9% 89.4% 39.1% 2.6% 1.3% 1.3% 0.7% 11.9%


False negatives for SM-4 (controlled substances) (techinque(s) used or ANP)

Code: PF5IJN (ANP)


Cocaine: 150

92





Deviation from robust average

z-scoreConcentration

(mass%)


averagez-score

0J0PYS 83.5 5.5 1.3 HYEPEU 80.0 2.0 0.50LN2QE 78.1 0.1 0.0 HYRH0O 93.5 15.5 3.60N05YR 88.0 10.0 2.4 I3W3SW 80.6 2.6 0.60RE0L0 71.0 -7.0 -1.6 IJ37J2 81.0 3.0 0.71SAEBM 78.9 0.9 0.2 IM8WG1 80.7 2.7 0.620LMZF 76.4 -1.6 -0.4 IMEQDK 81.7 3.7 0.928YACH 85.5 7.5 1.8 IOP7DS 74.3 -3.7 -0.92H9171 73.6 -4.4 -1.0 IRIBPI 78.0 0.0 0.03MGTTL 78.2 0.2 0.0 IT3XHS 92.7 14.7 3.53UMO3Y 77.3 -0.7 -0.2 J1X7S4 81.9 3.9 0.93V0OFD 72.0 -6.0 -1.4 JA3JJQ 74.9 -3.1 -0.7555YH5 61.8 -16.2 -3.8 K2D2PO 81.8 3.8 0.9

5WSWTT 89.5 11.5 2.7 KN4PSK 76.7 -1.3 -0.35ZW2N9 68.0 -10.0 -2.3 KX18KO 79.0 1.0 0.26306WG 79.8 1.8 0.4 KYGWUS 77.0 -1.0 -0.2666F66 72.0 -6.0 -1.4 LG45WT 84.8 6.8 1.67K1RKK 79.0 1.0 0.2 LLLSLL 80.0 2.0 0.57WPIJX 78.0 0.0 0.0 LYWXR6 79.2 1.2 0.38GORYY 77.6 -0.4 -0.1 MJHGVG 79.4 1.4 0.38SVPRT 66.6 -11.4 -2.7 MRWDWG 74.7 -3.3 -0.88YSG8M 78.3 0.3 0.1 NHY1ZE 10.4 -67.6 -15.98ZZZO7 75.2 -2.8 -0.7 NNBNTN 79.2 1.2 0.3AEE5WA 72.0 -6.0 -1.4 NSJNGB 78.9 0.9 0.2AGNIZI 68.7 -9.3 -2.2 NU06C7 76.8 -1.2 -0.3AIPPIG 72.0 -6.0 -1.4 OGLNKI 77.3 -0.7 -0.2

ANHVML 81.0 3.0 0.7 OLLRLR 72.9 -5.1 -1.2BPLP0L 83.7 5.7 1.3 ORHNDM 78.0 0.0 0.0C9TTRY 82.0 4.0 0.9 PF5IJN 88.5 10.5 2.5CWGDML 80.0 2.0 0.5 PPHBGP 48.7 -29.3 -6.9D5BVEI 76.6 -1.4 -0.3 Q11YO1 75.5 -2.5 -0.6DFCXDG 66.3 -11.7 -2.7 Q8ECTW 77.3 -0.7 -0.2DLDLOB 72.7 -5.3 -1.2 QIEBZB 79.4 1.4 0.3DNKLDD 77.0 -1.0 -0.2 QOOCT8 77.0 -1.0 -0.2DQEDDN 76.8 -1.2 -0.3 QTTSCI 73.0 -5.0 -1.2DQMISD 80.8 2.8 0.7 RJXPPP 88.0 10.0 2.4DYEYYG 78.3 0.3 0.1 RXKBFM 76.7 -1.3 -0.3EBQAXY 78.0 0.0 0.0 SF9898 78.4 0.4 0.1ELN44T 75.9 -2.1 -0.5 SGDY90 70.0 -8.0 -1.9EMZZIW 35.0 -43.0 -10.1 TIILNU 78.9 0.9 0.2ET1YHT 84.4 6.4 1.5 TLVU3E 77.8 -0.2 0.0FIKSPK 73.0 -5.0 -1.2 U54UUY 80.2 2.2 0.5FL6M38 78.0 0.0 0.0 ULXUTD 76.8 -1.2 -0.3FO8JOE 79.1 1.1 0.3 V3BKMA 76.0 -2.0 -0.5

GCGWXG 84.0 6.0 1.4 V43UFL 80.0 2.0 0.5GEZZ2P 100.0 22.0 5.2 VJMKCE 78.0 0.0 0.0H74EH5 77.0 -1.0 -0.2 VLJXIU 77.0 -1.0 -0.2

HCW3AW 74.8 -3.2 -0.7 VLLLV0 84.9 6.9 1.6HCZG6T 77.4 -0.6 -0.1 VMHH2Y 72.0 -6.0 -1.4

Code

Cocaine

Code

Cocaine

93





averagez-score

VZSIJV 81.1 3.1 0.7XGELS2 80.3 2.3 0.5XH2D7F 80.5 2.5 0.6XL5KA0 81.6 3.6 0.8XVDW7X 60.0 -18.0 -4.2YCYBYW 90.5 12.5 2.9YWZYAR 80.0 2.0 0.5YYDEDD 80.3 2.3 0.5Z8YS9F 79.5 1.5 0.4ZM99S9 93.1 15.1 3.6ZZKXPP 70.0 -8.0 -1.9

Cocaine

Code

94

Substance: SM-4/Cocaine Robust average = 78.0 UNODC value = 75.8

Round: 2014/1


‐3.8

‐2.7 ‐2.7

‐2.3 ‐2.2‐1.9

‐1.9 ‐1

.6 ‐1.4

‐1.4

‐1.4

‐1.4

‐1.4 ‐1.2 ‐1.2

‐1.2

‐1.2 ‐1.0 ‐0.9 ‐0.8

‐0.7

‐0.7 ‐0.7 ‐0.6 ‐0.5

‐0.5 ‐0.4 ‐0.3

‐0.3

‐0.3

‐0.3

‐0.3

‐0.3 ‐0.2

‐0.2

‐0.2

‐0.2

‐0.2 ‐0.2

‐0.2

‐0.2

‐0.1 ‐0.1 0.0 0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0 0.1

0.1

0.1 0.2

0.2

0.2

0.2

0.2

0.3

0.3

0.3 0.3

0.3 0.4 0.4 0.5

0.5

0.5

0.5

0.5 0.5

0.5

0.5 0.6 0.6

0.6

0.7 0.7

0.7

0.7 0.8

0.9 0.9 0.9

0.9

1.3 1.3 1.4 1.5 1.6

1.6 1.8

2.4

2.4 2.5 2.

7 2.9

3.5 3.6 3.6

‐4.0

‐3.0

‐2.0

‐1.0

0.0

1.0

2.0

3.0

4.0

NHY1ZE

EMZZIW

PPHBG

PXV

DW7X

555YH5

DFCXD

G8SVP

RT5ZW2N

9AG

NIZI

SGDY

90ZZKX

PP0R

E0L0

VMHH2

Y3V

0OFD

AIPP

IG666F66

AEE5WA

DLD

LOB

OLLRLR

FIKSPK

QTTSCI

2H91

71IOP7

DS

MRW

DWG

HCW

3AW

JA3JJQ

8ZZZO7

Q11YO

1ELN44

TV3

BKMA

20LM

ZFD5B

VEI

RXKB

FMKN

4PSK

ULXUTD

NU06

C7DQED

DNKY

GWUS

H74

EH5

QOOCT

8VLJXIU

DNKLDD

Q8ECT

W3U

MO3Y

OGLN

KIHCZG6T

8GORY

YTLVU

3EIRIBPI

FL6M

38VJMKC

EORH

NDM

7WPIJX

EBQAX

Y0LN2Q

E3M

GTTL

8YSG

8MDYEYYG

SF9898

1SAE

BMTIILNU

NSJNGB

KX18KO

7K1R

KKFO

8JOE

LYWXR

6NNBN

TNQIEBZ

BMJHGVG

Z8YS9F

6306WG

CWGDM

LHYEPE

ULLLSLL

V43U

FLYW

ZYAR

U54

UUY

YYDED

DXG

ELS2

XH2D

7FI3W3SW

IM8W

G1

DQMISD

ANHVM

LIJ3

7J2

VZSIJV

XL5K

A0IM

EQDK

K2D2P

OJ1X7

S4C9

TTRY

0J0P

YSBP

LP0L

GCG

WXG

ET1YHT

LG45WT

VLLLV0

28YA

CH0N

05YR

RJXP

PPPF5IJN

5WSW

TTYC

YBYW

IT3X

HS

ZM99

S9HYR

H0O

GEZZ2P

‐15.9

‐10.1

‐6.9

‐4.2

5.2





95

The Laboratory and Scientific SectionUNODC, International CentreWagramer Strasse 5, P.O. Box 500A-1400, Vienna, AUSTRIAEmail: [email protected]



96

INTERNATIONAL QUALITY ASSURANCE … · ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE...

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