111 human carotid mri spio
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Transcript of 111 human carotid mri spio
Non-invasive Detection of Vulnerable Plaque Using
SPIO Enhanced MRI
Everybody has atherosclerosis, the question is who has Vulnerable Plaque
The Online Cardiovascular Research Community
www.VulnerablePlaque.org
All slides will be available on:
Vulnerable Plaque?
Atherosclerotic plaques that cause sudden luminal clot formation and lead to heart attack and stroke.
Different Types of Vulnerable Plaque As underlying Cause of Acute Coronary Events
NormalRupture-prone
Fissured ErodedCritical Stenosis Hemorrhage
Carotid artery plaqueCCA
Carotid bifurcation
ICA stenosis & plaque
Courtesy of
Dr. Chun Yuan University of Washington, Seattle
Plaque Morphology Vs.
Plaque Activity
Why do we need to go beyond morphological assessment of plaques? Why do we need both?
The short answer is: because not all plaques with similar morphology would result in similar outcome.
SPIO Super Paramagnetic Iron Oxide
Colloidal coated particles of iron oxide, e.g. dextran coated SPIO (Feridex I.V.)
Weissleder R et al. (1997)
Schmitz et al J. Inv. Radiol. 2000
Non-invasive MRI study of atherosclerotic plaques using SPIO (pre and post injection comparison) may be a likely method for detection of vulnerable plaques
Further studies particularly human clinical trials are warranted
SPIO Clinical Trial:- The first human clinical trial on
detection of carotid vulnerable plaque using SPIO in patients undergoing carotid endartherectomy
Baseline
Scan
SPIO Injection
1hr post-injection
5days
ScanSurgery
WWW.HotPlaque.Com