Spio cytokinejan28
29
Cytokine-SPIO Protocol •Purpose: To compare the iron particles present in macrophages of apo E-deficient atherosclerotic plaques under baseline conditions (control group) and after the administration of the cytokines TNF-alpha and IL-1beta (test group). •Protocol: Eight retired female breeders, approximately 12-month old were divided in 2 groups. Five received I.P. 0.2 µg each of mouse recombinant TNF- and IL-1ß; the 3 control received 0.5 mL saline
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Transcript of Spio cytokinejan28
Cytokine-SPIO Protocol•Purpose: To compare the iron particles present in macrophages of apo E-deficient atherosclerotic plaques under baseline conditions (control group) and after the administration of the cytokines TNF-alpha and IL-1beta (test group). •Protocol: Eight retired female breeders, approximately 12-month old were divided in 2 groups. Five received I.P. 0.2 µg each of mouse
recombinant TNF- and IL-1ß; the 3 control received 0.5 mL saline containing 1% BSA. Three hours later, all the animals were I.V. injected with Feridex 1 mMol/kg of iron. Seven days later, the recipients were euthanized with CO2 and perfused under physiological pressure.The entire aorta up to the iliac bifurcation was formalin-fixed, serially sectioned transversally and stained for H&E and iron.
No cytokines
C1Cx10
No cytokines
C1Cx40
No cytokines
C3Ex10
No cytokines
Only plaque with FeC3Ex40
No cytokines
C3E
TNF/IL-1ß
T2Fx10
TNF/IL-1ß
T2Fx40
TNF/IL-1ß
T2Fx40ab
TNF/IL-1ß
T2Fx40cd
TNF/IL-1ß
T3Fx10
Coronary artery involvement
T3F coronary
TNF/IL-1ß
T3Fx40
TNF/IL-1ß
T4Bx10
TNF/IL-1ß
T4Bx40
TNF/IL-1ß
T4B
TNF/IL-1ß
T4F
TNF/IL-1ß
T4Cx10
TNF/IL-1ß
T4Cx40
TNF/IL-1ß
T4Fx10
TNF/IL-1ß
T4Fx10bc
Infarct and coronary involvement
T4F
TNF/IL-1ß
T4Fx40bcd
TNF/IL-1ß
T3Ex10
TNF/IL-1ß
T3Efex40
TNF/IL-1ß
T3Bx10
TNF/IL-1ß
T3Bx40ab
TNF/IL-1ß
T3Bfex40ab
TNF/IL-1ß
T4E
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