Spontaneous Damage to DNA

Examples of DNA Damage Induced by Radiation and Chemicals

Examples of DNA Damage Induced by Radiation and Chemicals

Direct Repair of Thymine Dimers

Not in humans

A metiltransferase é gasta nesta reacção

Base-Excision Repair

Nucleotide-Excision Repair of Thymine Dimers

Xeroderma pigmentosum

•Autosomal recessive mutations in several complementation groups

•Extreme sensitivity to sunlight

•Predisposition to skin cancer (mean age of skin cancer = 8 yrs vs. 60 for normal population)

Nucleotide excision repair - Energéticamente ineficiente

Mismatch Repair in E. coli

Teste de Ames para agentes mutagenicos