Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals.

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Spontaneous Damage to DNA

Transcript of Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals.

Page 1: Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals.

Spontaneous Damage to DNA

Page 2: Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals.

Examples of DNA Damage Induced by Radiation and Chemicals

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Examples of DNA Damage Induced by Radiation and Chemicals

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Direct Repair of Thymine Dimers

Not in humans

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A metiltransferase é gasta nesta reacção

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Base-Excision Repair

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Nucleotide-Excision Repair of Thymine Dimers

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Xeroderma pigmentosum

•Autosomal recessive mutations in several complementation groups

•Extreme sensitivity to sunlight

•Predisposition to skin cancer (mean age of skin cancer = 8 yrs vs. 60 for normal population)

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Nucleotide excision repair - Energéticamente ineficiente

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Mismatch Repair in E. coli

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Page 13: Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals.

Teste de Ames para agentes mutagenicos


DNA Damage. DNA damage DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000.

DNA Damage. DNA damage DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000.

Dna damage and repair

Dna damage and repair

Definitions: ★ replication errors ★ spontaneous DNA damage ★ DNA mutations ★ double-strand break (DSB) repair pathway.

Definitions: ★ replication errors ★ spontaneous DNA damage ★ DNA mutations ★ double-strand break (DSB) repair pathway.

DNA Damage and DNA Repair - University of North Carolina ... · Possible Consequences of DNA Damage DNA Damage Via UV, oxidation or methylation damage Mutation Cell Death Nothing

DNA Damage and DNA Repair - University of North Carolina ... · Possible Consequences of DNA Damage DNA Damage Via UV, oxidation or methylation damage Mutation Cell Death Nothing

AXL Inhibition Suppresses the DNA Damage Response and ......DNA Damage and Repair AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple

AXL Inhibition Suppresses the DNA Damage Response and ......DNA Damage and Repair AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple

DNA damage & Repair

DNA damage & Repair

Dna Damage Nd Repair

Dna Damage Nd Repair

Dna Damage Helle

Dna Damage Helle

DNA DAMAGE AND REPAIR dna damage and repair - … 01. DNA damage and... · 2 dna damage and repair 1.1 single molecules and dna The information essential for life is stored and encoded

DNA DAMAGE AND REPAIR dna damage and repair - … 01. DNA damage and... · 2 dna damage and repair 1.1 single molecules and dna The information essential for life is stored and encoded

Arginine Supplementation and DNA Damage

Arginine Supplementation and DNA Damage

the DNA Damage Response

the DNA Damage Response

DNA damage tolerance pathway involving DNA polymerase ι and ...

DNA damage tolerance pathway involving DNA polymerase ι and ...

Differences in DNA damage and repair in human …candle.am/wp-content/uploads/2017/12/NellyBabayan.pdfEvery cell experiences up to 10 5 spontaneous or induced DNA lesions per day Research

Differences in DNA damage and repair in human …candle.am/wp-content/uploads/2017/12/NellyBabayan.pdfEvery cell experiences up to 10 5 spontaneous or induced DNA lesions per day Research

Oxidative Damage of DNA

Oxidative Damage of DNA

DNA Damage - Columbus Labs · DNA Damage Figure 5-46. A summary of spontaneous alterations likely to require DNA repair. The sites on each nucleotide that are known to be modified

DNA Damage - Columbus Labs · DNA Damage Figure 5-46. A summary of spontaneous alterations likely to require DNA repair. The sites on each nucleotide that are known to be modified

Satellite RNA Increases DNA Damage and Accelerates Tumor Formation … · DNA Damage and Repair Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models

Satellite RNA Increases DNA Damage and Accelerates Tumor Formation … · DNA Damage and Repair Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models

DNA Damage Response_nature

DNA Damage Response_nature

DNA Damage, DNA Technologies, Genetics Since Gregor Mendel

DNA Damage, DNA Technologies, Genetics Since Gregor Mendel

DNA damage and repair lecture - unc.edu · DNA damage and repair ... Fanconi’s anemia - DNA repair. BRCA2 and 5 other genes ... Microsoft PowerPoint - DNA damage and repair lecture.ppt

DNA damage and repair lecture - unc.edu · DNA damage and repair ... Fanconi’s anemia - DNA repair. BRCA2 and 5 other genes ... Microsoft PowerPoint - DNA damage and repair lecture.ppt

Dna damage checkpoints

Dna damage checkpoints