Stimulus Effect on GFR Effect on RBF VASOCONSTRICTORS

Sympathetic nerves ↓ ECV ↓ ↓AT-II ↓ ECV ↓ ↓Endothelin ↓ ECV

↑ Stretch AT IIBradykinin Epinephrine

↓ ↓

Adenosine ↓ ↓ ATP *constricts AA

↓ ↓

VASODILATORSProstaglandins ↓ ECV

↑ Stretch AT II

NO CHANGE ↑

NO ↑ Stretch AchHistamine BradykininATP

↑ ↑

Bradykinin Prostaglandin ↓ ACEenzyme

↑ ↑

ANP & BNP*vasoconstrictor of efferent

↑ ECV ↑ ↑(modest change)

ATP *stimulates NO production

↑ ↑

Glucocorticoids ↑ ↑Dopamine