Hormonal Control
1
Stimulus Effect on GFR Effect on RBF VASOCONSTRICTORS Sympathetic nerves ↓ ECV ↓ ↓ AT-II ↓ ECV ↓ ↓ Endothelin ↓ ECV ↑ Stretch AT II Bradykinin Epinephrine ↓ ↓ Adenosine ↓ ↓ ATP *constricts AA ↓ ↓ VASODILATORS Prostaglandins ↓ ECV ↑ Stretch AT II NO CHANGE ↑ NO ↑ Stretch Ach Histamine Bradykinin ATP ↑ ↑ Bradykinin Prostaglandin ↓ ACEenzyme ↑ ↑ ANP & BNP *vasoconstrictor of efferent ↑ ECV ↑ ↑ (modest change) ATP *stimulates NO production ↑ ↑ Glucocorticoids ↑ ↑ Dopamine
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Transcript of Hormonal Control
Stimulus Effect on GFR Effect on RBF VASOCONSTRICTORS
Sympathetic nerves ↓ ECV ↓ ↓AT-II ↓ ECV ↓ ↓Endothelin ↓ ECV
↑ Stretch AT IIBradykinin Epinephrine
↓ ↓
Adenosine ↓ ↓ ATP *constricts AA
↓ ↓
VASODILATORSProstaglandins ↓ ECV
↑ Stretch AT II
NO CHANGE ↑
NO ↑ Stretch AchHistamine BradykininATP
↑ ↑
Bradykinin Prostaglandin ↓ ACEenzyme
↑ ↑
ANP & BNP*vasoconstrictor of efferent
↑ ECV ↑ ↑(modest change)
ATP *stimulates NO production
↑ ↑
Glucocorticoids ↑ ↑Dopamine
