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Cebu Normal UniversityCollege of Nursing
Osmenia Blvd. Cebu City 6000
NAS III Pharmacology, Therapeutics and Diagnostics
DRUG STUDY
Name of Patient Age Height
Diagnosis Sex Weight
Doctor Date of Admission Body Build
Drug Data Classification Mechanism of Action Indication
Generic Nameomeprazole
Trade NameLosec, Prilosec
Patients Dose
Minimum Dose
Maximum Dose
Contents
AvailabilityCapsules (delayed-release):10 mg, 20 mg, 40 mg
Routes of administrationPO
Pharmacologic Classproton pump inhibitors
Therapeutic ClassAntiulcer agents
Pregnancy Risk CategoryC
Inhibits activity of acid (proton) pump, and binds tohydrogen-potassium adenosine triphosphatase,located at secretory surface of the gastric parietalcells, to block formation of gastric acid.
Pharmacokinetics
Onset
Peak
Duration
Drug Half Life
General Indications
Symptomatic gastroesophageal reflux disease(GERD) without esophageal lesions
Erosive esophagitis and accompanyingsymptoms caused by GERD
Maintenance of healing erosive esophagitis
Pathologic hypersecretory conditions (such asZollinger-Ellison syndrome)
Duodenal ulcer (short-term treatment)
Helicobacter pylori infection and duodenal ulcerdisease, to eradicate H. pylori withclarithromycin (dual therapy)
H. pylori infection and duodenal ulcer disease,to eradicate H. pylori with clarithromycin andamoxicillin (triple therapy)
Short-term treatment of active benign gastriculcer
Patients Actual Indication
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Contraindications Adverse Reactions Nursing Responsibilities
Contraindicated in:Contraindicated in patients hypersensitive todrug or its components.
PrecautionUse cautiously with pregnancy, lactation
Drug interactionDrug-drug.
Ampicillin esters, iron derivatives,ketoconazole: may exhibit poor bioavailabilityin patients taking omeprazole becauseoptimal absorption of these drugs needs alow gastric pH. Avoid using together.Diazepam, phenytoin, warfarin: decreaseshepatic clearance, possibly leading toincreased serum levels. Monitor closely.Drug-herb.Male fern: male fern is inactivated in alkalineenvironments. Patient should separateadministration.
Pennyroyal: may change rate of formation oftoxic metabolites of pennyroyal. Avoid usingtogether.
CNS: headache, dizziness, asthenia
GI: diarrhea, abdominal pain, nausea, vomiting,constipation, flatulence
Musculoskeletal: back pain
Respiratory: cough, upper respiratory tract infection
Skin: rash
Before
Assess patients history: Hypersensitivity to omeprazole orany of its components; pregnancy, lactation
Conduct physical assessment: Skin lesions; T; reflexes,affect; urinary output, abdominal exam; respiratoryauscultation
Dosage adjustments aren't needed for patients with renalor hepatic impairment.
Omeprazole increases its own bioavailability with repeateddosages. Drug is labile in gastric acid; less drug is lost tohydrolysis because drug increases gastric pH.
Don't confuse Prilosec with Prozac, Prilocaine, or Prinivil.During
Tell patient to swallow capsules whole and not to open,crush, or chew them.
Administer drug 30 minutes before meals.
Administer antacids with omeprazole, if needed.
After
Caution patient not to perform hazardous activities ifdizziness occurs
Arrange for further evaluation of patient after 8 wks oftherapy for gastroreflux disorders; not intended formaintenance therapy.
Instruct patient to have regular medical follow-up visits.
Inform patient of the possible side effects of drug andadvise to consult with your health care provider ifuncomfortable
Advise patient to report severe headache, worsening ofsymptoms, fever, and chills.
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