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Cebu Normal UniversityCollege of Nursing

Osmenia Blvd. Cebu City 6000

NAS III Pharmacology, Therapeutics and Diagnostics

DRUG STUDY

Name of Patient Age Height

Diagnosis Sex Weight

Doctor Date of Admission Body Build

Drug Data Classification Mechanism of Action Indication

Generic Nameomeprazole

Trade NameLosec, Prilosec

Patients Dose

Minimum Dose

Maximum Dose

Contents

AvailabilityCapsules (delayed-release):10 mg, 20 mg, 40 mg

Routes of administrationPO

Pharmacologic Classproton pump inhibitors

Therapeutic ClassAntiulcer agents

Pregnancy Risk CategoryC

Inhibits activity of acid (proton) pump, and binds tohydrogen-potassium adenosine triphosphatase,located at secretory surface of the gastric parietalcells, to block formation of gastric acid.

Pharmacokinetics

Onset

Peak

Duration

Drug Half Life

General Indications

Symptomatic gastroesophageal reflux disease(GERD) without esophageal lesions

Erosive esophagitis and accompanyingsymptoms caused by GERD

Maintenance of healing erosive esophagitis

Pathologic hypersecretory conditions (such asZollinger-Ellison syndrome)

Duodenal ulcer (short-term treatment)

Helicobacter pylori infection and duodenal ulcerdisease, to eradicate H. pylori withclarithromycin (dual therapy)

H. pylori infection and duodenal ulcer disease,to eradicate H. pylori with clarithromycin andamoxicillin (triple therapy)

Short-term treatment of active benign gastriculcer

Patients Actual Indication

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Contraindications Adverse Reactions Nursing Responsibilities

Contraindicated in:Contraindicated in patients hypersensitive todrug or its components.

PrecautionUse cautiously with pregnancy, lactation

Drug interactionDrug-drug.

Ampicillin esters, iron derivatives,ketoconazole: may exhibit poor bioavailabilityin patients taking omeprazole becauseoptimal absorption of these drugs needs alow gastric pH. Avoid using together.Diazepam, phenytoin, warfarin: decreaseshepatic clearance, possibly leading toincreased serum levels. Monitor closely.Drug-herb.Male fern: male fern is inactivated in alkalineenvironments. Patient should separateadministration.

Pennyroyal: may change rate of formation oftoxic metabolites of pennyroyal. Avoid usingtogether.

CNS: headache, dizziness, asthenia

GI: diarrhea, abdominal pain, nausea, vomiting,constipation, flatulence

Musculoskeletal: back pain

Respiratory: cough, upper respiratory tract infection

Skin: rash

Before

Assess patients history: Hypersensitivity to omeprazole orany of its components; pregnancy, lactation

Conduct physical assessment: Skin lesions; T; reflexes,affect; urinary output, abdominal exam; respiratoryauscultation

Dosage adjustments aren't needed for patients with renalor hepatic impairment.

Omeprazole increases its own bioavailability with repeateddosages. Drug is labile in gastric acid; less drug is lost tohydrolysis because drug increases gastric pH.

Don't confuse Prilosec with Prozac, Prilocaine, or Prinivil.During

Tell patient to swallow capsules whole and not to open,crush, or chew them.

Administer drug 30 minutes before meals.

Administer antacids with omeprazole, if needed.

After

Caution patient not to perform hazardous activities ifdizziness occurs

Arrange for further evaluation of patient after 8 wks oftherapy for gastroreflux disorders; not intended formaintenance therapy.

Instruct patient to have regular medical follow-up visits.

Inform patient of the possible side effects of drug andadvise to consult with your health care provider ifuncomfortable

Advise patient to report severe headache, worsening ofsymptoms, fever, and chills.

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