Web view · 2018-03-02... OR prognos*[Text Word] OR predict*[Text Word] OR course*[Text...

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Transcript of Web view · 2018-03-02... OR prognos*[Text Word] OR predict*[Text Word] OR course*[Text...

Supplementary Material

Supplementary Methods. Search strategy

We performed a systematic search of MEDLINE and Embase in January 2017 for clinical studies on risk factors for ventricular arrhythmias in patients with ARVC. Our search string consisted of three components which were simultaneously entered; (1) ARVC and synonyms; (2) ventricular arrhythmia or appropriate ICD therapy or sudden cardiac death, including synonyms; and (3) a previously validated string-based filter for prognostic research*, which was extended for the purpose of this review to minimize loss of eligible studies. We also searched through the reference lists of included articles and previously published reviews for additional relevant articles. Mendeley software (version 1.17.10, Elsevier, London, UK) was used to manage and de-duplicate all identified studies. The complete search string is presented in below.

* Haynes RB, McKibbon KA, Wilczynski NL, Walter SD, Werre SR, Hedges Team: Optimal search strategies for retrieving scientifically strong studies of treatment from Medline: analytical survey. BMJ 2005; 330:1179.

PubMed

Domain:

"arrhythmogenic cardiomyopathy"[Title/Abstract] OR "arrhythmogenic right ventricular cardiomyopathy"[Title/Abstract] OR "arrhythmogenic right ventricular cardiomyopathy/dysplasia"[Title/Abstract] OR "arrhythmogenic right ventricular dysplasia"[Title/Abstract] OR "arrhythmogenic right ventricular dysplasia/cardiomyopathy"[Title/Abstract] OR "arrhythmogenic right ventricular dysplasia cardiomyopathy"[Title/Abstract] OR "arrhythmogenic right ventricular cardiomyopathy dysplasia"[Title/Abstract] OR "arvc"[Title/Abstract] OR "arvc/d"[Title/Abstract] OR "arvc/arvd"[Title/Abstract] OR "arvd"[Title/Abstract] OR "arvd/arvc"[Title/Abstract] OR "arvd/c"[Title/Abstract] OR "arrhythmogenic right ventricular dysplasia"[MeSH Terms] OR "desmosomal mutation"[Title/Abstract] OR "desmosomal mutations"[Title/Abstract] OR "desmosome mutation"[Title/Abstract] OR "desmosome mutations"[Title/Abstract]

AND

Outcome:

"arrhythmic outcome"[Title/Abstract] OR "arrhythmic risk"[Title/Abstract] OR "arrhythmic events"[Title/Abstract] OR "ventricular flutter"[MeSH Terms] OR "ventricular flutter"[Title/Abstract] OR "ventricular flutters"[Title/Abstract] OR "ventricular arrhythmia"[Title/Abstract] OR "sudden cardiac arrest"[Title/Abstract] OR "sudden cardiac death"[Title/Abstract] OR "scd"[Title/Abstract] OR "sca"[Title/Abstract] OR "death, sudden, cardiac"[MeSH Terms] OR "malignant arrhythmia"[Title/Abstract] OR "malignant arrhythmias"[Title/Abstract] OR "malignant arrhythmic event"[Title/Abstract] OR "malignant arrhythmic events"[Title/Abstract] OR "tachycardia, ventricular"[MeSH Terms] OR "ventricular tachycardia"[Title/Abstract] OR "ventricular fibrillation"[MeSH Terms] OR "ventricular fibrillation"[Title/Abstract] OR "appropriate icd activation"[Title/Abstract] OR "appropriate icd discharge"[Title/Abstract] OR "appropriate icd discharges"[Title/Abstract] OR "appropriate icd firing"[Title/Abstract] OR "appropriate icd intervention"[Title/Abstract] OR "appropriate icd interventions"[Title/Abstract] OR "appropriate icd shock"[Title/Abstract] OR "appropriate icd shock therapy"[Title/Abstract] OR "appropriate icd shocks"[Title/Abstract] OR "appropriate icd therapies"[Title/Abstract] OR "appropriate icd therapy"[Title/Abstract] OR "appropriate icd treatment"[Title/Abstract] OR "appropriate icd treatments"[Title/Abstract] OR "heart arrest"[MeSH Terms] OR "heart arrest"[Title/Abstract] OR "cardiac arrest"[Title/Abstract] OR "wide complex tachycardia"[Title/Abstract] OR "wide complex tachycardias"[Title/Abstract] OR "wide complex ventricular"[Title/Abstract] OR "wide complex ventricular tachycardia"[Title/Abstract] OR "broad complex tachycardia"[Title/Abstract] OR "broad complex tachycardias"[Title/Abstract]

AND

Filter:

incidence[MeSH Terms] OR mortality[MeSH Terms] OR follow up studies[MeSH Terms] OR prognos*[Text Word] OR predict*[Text Word] OR course*[Text Word] OR cohort[Text Word] OR outcome*[Text Word] OR surviv*[Text Word]

Embase

Domain:

'heart right ventricle dysplasia'/exp OR arrhythmogenic cardiomyopathy:ab,ti OR arrhythmogenic right ventricular cardiomyopathy:ab,ti OR arrhythmogenic right ventricular cardiomyopathy/dysplasia:ab,ti OR arrhythmogenic right ventricular dysplasia:ab,ti OR arrhythmogenic right ventricular dysplasia/cardiomyopathy:ab,ti OR arrhythmogenic right ventricular dysplasia cardiomyopathy:ab,ti OR arrhythmogenic right ventricular cardiomyopathy dysplasia:ab,ti OR arvc:ab,ti OR arvc/d:ab,ti OR arvc/arvd:ab,ti OR arvd:ab,ti OR arvd/arvc:ab,ti OR arvd/c:ab,ti OR desmosomal mutation:ab,ti OR desmosomal mutations:ab,ti OR desmosome mutation:ab,ti OR desmosome mutations:ab,ti

AND

Outcome:

heart ventricle flutter'/exp OR ventricular flutter:ab,ti OR ventricular flutters:ab,ti OR ventricular arrhythmia:ab,ti OR sudden cardiac arrest:ab,ti OR sudden cardiac death:ab,ti OR scd:ab,ti OR sca:ab,ti OR 'sudden cardiac death'/exp OR malignant arrhythmia:ab,ti OR malignant arrhythmias:ab,ti OR malignant arrhythmic event:ab,ti OR malignant arrhythmic events:ab,ti OR 'heart ventricle tachycardia'/exp OR ventricular tachycardia:ab,ti OR 'heart ventricle fibrillation'/exp OR ventricular fibrillation:ab,ti OR appropriate icd activation:ab,ti OR appropriate icd discharge:ab,ti OR appropriate icd discharges:ab,ti OR appropriate icd firing:ab,ti OR appropriate icd intervention:ab,ti OR appropriate icd interventions:ab,ti OR appropriate icd shock:ab,ti OR appropriate icd shock therapy:ab,ti OR appropriate icd shocks:ab,ti OR appropriate icd therapies:ab,ti OR appropriate icd therapy:ab,ti OR appropriate icd treatment:ab,ti OR appropriate icd treatments:ab,ti OR 'heart arrest'/exp OR heart arrest:ab,ti OR cardiac arrest:ab,ti OR wide complex tachycardia:ab,ti OR wide complex tachycardias:ab,ti OR wide complex ventricular:ab,ti OR wide complex ventricular tachycardia:ab,ti OR broad complex tachycardia:ab,ti OR broad complex tachycardias:ab,ti

AND

Filter:

'incidence'/exp OR 'mortality'/exp OR 'follow up'/exp OR prognos* OR predict* OR course* OR cohort OR outcome* OR surviv*

Supplementary Methods. Study Selection and Data Extraction

Eligibility of each study was assessed by two investigators independently (LPB and AZS). In case of disagreement, consensus was obtained from a third investigator (ASJMTR). If a site-specific dataset had been published more than once, we compared the reported list of risk factors for overlap, in which case only the results obtained in the largest patient population was included. One investigator (LPB) extracted data using pre-specified forms detailing the following information: study design, study size, definition of patient population, baseline characteristics (age and sex), follow-up duration, outcome definitions, and covariate-specific risk estimates with 95% CI. Data extraction was checked for adequacy by another investigator (AZS). Both crude and maximally adjusted risk estimates were collected.

Supplementary Methods. Quality in Prognostic Studies (QUIPS) tool

Domain

Risk of bias

1. Study participation

a) Adequate participation in the study by eligible persons

b) Description of the source population or population of interest

c) Description of the baseline study sample

d) Adequate description of the sampling frame and recruitment

e) Adequate description of the period and place of recruitment

f) Adequate description of inclusion and exclusion criteria

High: The relationship between the PF and outcome is very likely to be different for participants and eligible nonparticipants

Moderate: The relationship between the PF and outcome may be different for participants and eligible nonparticipants

Low: The relationship between the PF and outcome is unlikely to be different for participants and eligible nonparticipants

2. Study attrition

a) Adequate response rate for study participants

b) Description of attempts to collect information on participants who dropped out

c) Reasons for loss to follow-up are provided

d) Adequate description of participants lost to follow-up

e) There are no important differences between participants who completed the study and those who did not

High: The relationship between the PF and outcome is very likely to be different for completing and non-completing participants

Moderate: The relationship between the PF and outcome may be different for completing and non-completing participants

Low: The relationship between the PF and outcome is unlikely to be different for completing and non-completing participants

3. Prognostic factor measurement

a) A clear definition or description of the PF is provided

b) Method of PF measurement is adequately valid and reliable

c) Continuous variables are reported or appropriate cut points are used

d) The method and setting of measurement of PF is the same for all study participants

e) Adequate proportion of the study sample has complete data for the PF

f) Appropriate methods of imputation are used for missing PF data

High: The measurement of the PF is very likely to be different for different levels of the outcome of interest

Moderate: The measurement of the PF may be different for different levels of the outcome of interest

Low: The measurement of the PF is unlikely to be different for different levels of the outcome of interest

4. Outcome measurement

a) A clear definition of the outcome is provided

b) Method of outcome measurement used is adequately valid and reliable

c) The method a