The utility of measures of electrophysiological and information processing variability in...
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BioMed Central Page 1 of 1 (page number not for citation purposes) Annals of General Psychiatry Open Access Poster presentation The utility of measures of electrophysiological and information processing variability in distinguishing between normal age-related cognitive decline, Subjective Memory Complaint (SMC), Mild Cognitive Impairment (MCI), and Alzheimer's disease (AD) Michael Hogan* 1 , Richard Roche 2 , Paul Dockree 2 , Ian Robertson 2 and Brian Lawlor 2 Address: 1 NUI, Galway, Ireland and 2 Trinity College, Dublin, Ireland * Corresponding author Background Recent theoretical models of cognitive aging have impli- cated increased intra-individual variability as a critical marker of decline. The current study examined electro- physiological and information processing variability and memory performance in normal younger and older adults, and older adults with Subjective Memory Com- plaint (SMC), Mild Cognitive Impairment (MCI), and Alzheimer's Disease (AD). It was hypothesized that higher levels of variability would be indicative of age-related and disease-related memory deficits. Materials and methods 24 young, 24 old, 21 SMCs, 15 MCIs, and 16 ADs (Mean age = 21.5, 72.8, 71.8, 76, and 77 years, respectively) were recruited with informed consent and received clinical assessment (Hogan et al., 2003), neuropsychological screening, and electrophysiological assessment while per- forming an implicit and explicit memory task. Results Consistent with previous research, behavioural variability emerged as sensitive to age- and disease-related change. Results also indicated that amplitude variability (AmpV) of event-related potentials (ERPs) provide some addi- tional insight into the dynamic nature of age- and disease- related memory changes. Discussion Results are discussed in light of theoretical and applied issues in the field of cognitive aging. References 1. Hogan MJ, Swanwick GR, Kaiser J, Rowan M, Lawlor B: Memory- related EEG power and coherence reductions in mild Alzhe- imer's disease. Int J Psychophysiol 2003, 49:147-163. from International Society on Brain and Behaviour: 2nd International Congress on Brain and Behaviour Thessaloniki, Greece. 17–20 November 2005 Published: 28 February 2006 Annals of General Psychiatry 2006, 5(Suppl 1):S214 doi:10.1186/1744-859X-5-S1-S214 <supplement> <title> <p>International Society on Brain and Behaviour: 2nd International Congress on Brain and Behaviour</p> </title> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="http:// www.biomedcentral.com/content/files/pdf/1744-859X-5-S1-full.pdf">here</a>.</note> </supplement>
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Transcript of The utility of measures of electrophysiological and information processing variability in...
BioMed Central
Page 1 of 1(page number not for citation purposes)
Annals of General Psychiatry
Open AccessPoster presentationThe utility of measures of electrophysiological and information processing variability in distinguishing between normal age-related cognitive decline, Subjective Memory Complaint (SMC), Mild Cognitive Impairment (MCI), and Alzheimer's disease (AD)Michael Hogan*1, Richard Roche2, Paul Dockree2, Ian Robertson2 and Brian Lawlor2
Address: 1NUI, Galway, Ireland and 2Trinity College, Dublin, Ireland
* Corresponding author
BackgroundRecent theoretical models of cognitive aging have impli-cated increased intra-individual variability as a criticalmarker of decline. The current study examined electro-physiological and information processing variability andmemory performance in normal younger and olderadults, and older adults with Subjective Memory Com-plaint (SMC), Mild Cognitive Impairment (MCI), andAlzheimer's Disease (AD). It was hypothesized that higherlevels of variability would be indicative of age-related anddisease-related memory deficits.
Materials and methods24 young, 24 old, 21 SMCs, 15 MCIs, and 16 ADs (Meanage = 21.5, 72.8, 71.8, 76, and 77 years, respectively) wererecruited with informed consent and received clinicalassessment (Hogan et al., 2003), neuropsychologicalscreening, and electrophysiological assessment while per-forming an implicit and explicit memory task.
ResultsConsistent with previous research, behavioural variabilityemerged as sensitive to age- and disease-related change.Results also indicated that amplitude variability (AmpV)of event-related potentials (ERPs) provide some addi-tional insight into the dynamic nature of age- and disease-related memory changes.
DiscussionResults are discussed in light of theoretical and appliedissues in the field of cognitive aging.
References1. Hogan MJ, Swanwick GR, Kaiser J, Rowan M, Lawlor B: Memory-
related EEG power and coherence reductions in mild Alzhe-imer's disease. Int J Psychophysiol 2003, 49:147-163.
from International Society on Brain and Behaviour: 2nd International Congress on Brain and BehaviourThessaloniki, Greece. 17–20 November 2005
Published: 28 February 2006
Annals of General Psychiatry 2006, 5(Suppl 1):S214 doi:10.1186/1744-859X-5-S1-S214<supplement> <title> <p>International Society on Brain and Behaviour: 2nd International Congress on Brain and Behaviour</p> </title> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="http://www.biomedcentral.com/content/files/pdf/1744-859X-5-S1-full.pdf">here</a>.</note> </supplement>
