Targeting Bacterial Proteasomal Machinery
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Dysregulation of bacterial proteolytic machinery by a new class of antibiotics Brötz-Oesterhelt, H. et al. Nat. Med. 11, 1082-1087 (2005)
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Transcript of Targeting Bacterial Proteasomal Machinery
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
Brötz-Oesterhelt, H. et al.
Nat. Med. 11, 1082-1087 (2005)
Blocks DNA replicationDNA GyraseFluoroquinolones
DNA Replication/repair
Protein SynthesisPeptidyl TransferasesOxazolidinones
Protein SynthesisPeptidyl TransferasesAminoglycosides
Protein SynthesisPeptidyl TransferasesTetracyclins
Protein Synthesis
Sequestring substrate for biosynthesis
D-Ala-D-Ala TerminiVancomycin
Block crosslinking enzymesTranspeptidase/Transglycosylaseβ-Lactams
Cell Wall
Mode of Action TargetAntibiotic
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Copyright ©1999 by the National Academy of Sciences
Horwich, Arthur L. et al. (1999) Proc. Natl. Acad. Sci. USA 96, 11033-11040
Copyright ©1999 by the National Academy of Sciences
Horwich, Arthur L. et al. (1999) Proc. Natl. Acad. Sci. USA 96, 11033-11040
QuickTimeª and aTIFF (Uncompressed) decompressor
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