SUPPLEMENTAL FIGURE LEGENDS:

FIGURE S1. Multiple sequence alignment of SidP. The sequences of SidP from pathogenic bacteria were aligned by the Clustal Omega server (1) and colored by ALSCRIPT program (2). Residues numbers are labeled according to the LLO_3270 sequence. The conserved residues are shaded in yellow and completely identical residues are shaded in red. Secondary elements of SidP are draw under the alignment. The catalytic CX5R motif is marked by red triangles. Five conserved cationic residues that contribute the positive charges at the catalytic site are marked by blue dots. The hydrophobic loop is highlighted by a brown box. Entrez database accession numbers are as follow: LLO_3270: gi: 289166576; Lpg_0130: gi: 52840385; LPV_0148: gi : 397665762; LPC_0151: gi: 148358289; Lpp_0145: gi: 54296126; LPO_0140: gi : 397662684; LPW_01311: 307608875; Lpl_0130: gi: 54293092; FdumT_15202: gi: 388457923; LDG_6053: gi: 374261093; RICGR_1079: gi: 160871888. 1. Sievers F, et al. (2011) Fast, scalable generation of high-quality protein multiple

sequence alignments using Clustal Omega. Mol Syst Biol 7:539. 2. Barton GJ (1993) ALSCRIPT: a tool to format multiple sequence alignments. Protein

Eng 6(1):37-40.

FIGURE S1.

FIGURE S1. (cont.)