STUDY PROGRAM 2021/2022 Subjects of the 9-10. semesters ...

UP FP Pharmacy major – Obligatory subjects in the 9-10. rec. semester - Course descriptions – academic year of 2021/2022

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University of Pécs Faculty of Pharmacy

PHARMACY Major

STUDY PROGRAM 2021/2022

Subjects of the 9-10. semesters

(obligatory subjects and criterion requirements)


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Table of Contents

9th semester

OPG-D3E-T Pharmacodynamics 3 - Theory ___________________________________________________________________ 3

OPG-D3G-T Pharmacodynamics 3 - Practice __________________________________________________________________ 6

OPG-KL2-T Clinical Studies 2 _____________________________________________________________________________ 8

OPG-KLF-T Clinical Pharmacology ________________________________________________________________________ 11

OPG-KLV-T Clinical Laboratory Investigations _______________________________________________________________ 13

OPG-NOV-T Herbal Medicine and Herbs in Nutrition __________________________________________________________ 15

OPG-PRG-T Problemsolving Pharmacy _____________________________________________________________________ 17

OPG-SIE-T Pharmaceutical informatics - Theory _____________________________________________________________ 19

OPG-SIG-T Pharmaceutical informatics - Practice ____________________________________________________________ 21

OPG-TXA-T Toxicology _________________________________________________________________________________ 23

OPG-U4E-T Pharmaceutical Practice and Management 3 - Theory ________________________________________________ 26

OPG-U4G-T Pharmaceutical Practice and Management 3 - Practice _______________________________________________ 30

OPS-ZG1-T Professional Practice Before State Examination 1 ___________________________________________________ 33

10th semester

OPS-ZG2-T Professional Practice Before State Examination 2 ___________________________________________________ 36


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OPG-D3E-T PHARMACODYNAMICS 3 - THEORY

Course director: DR. GÁBOR ISTVÁN PETHŐ, professor

Department of Pharmacology [email protected]

2 credit ▪ final exam ▪ Pharm. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 9

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 1 – 100 Prerequisites: see your Recommended Curriculum

Topic

The aim of the course is to provide the students with pharmacological knowledge that is required for their future work in the pharmacy.

Important topics are pharmacology of the endocrine system; chemotherapy of microbial diseases including antibacterial, antifungal drugs,

antiviral antiprotozoal, antihelminthic agents, antiseptics and disinfectants; drugs used in chemotherapy of neoplastic diseases;

immunosuppressants, immunomodulators, drug treatment of rheumatoid arthritis. Further topics are pharmacogenetics; effects of age,

diet and diseases on drug action; drug interactions.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

There is no midterm exam/test.

Making up for missed classes

There is no way to make up for missed classes.

Reading material

- Obligatory literature

- Literature developed by the Department

Electronic handouts are provided for most topics.

- Notes

- Recommended literature

Rang, Dale, Ritter, Moore: Pharmacology, 9th edition, Elsevier Churchill Livingstone, 2019

B. G. Katzung (ed.): Basic and Clinical Pharmacology, 14th edition, Lange Medical Books/McGraw-Hill, 2018

Lectures

1 Corticosteroids I.

Dr. Pethő Gábor István

2 Corticosteroids II.


3 Corticosteroids III.


4 Estrogens, anti-estrogens


5 Progestins, anti-progestins


6 Postmenopausal hormone therapy. Hormonal contraceptives


7 Androgens, anabolic steroids, and anti-androgens I.


8 Androgens, anabolic steroids, and anti-androgens II.


9 Thyroid hormones, antithyroid drugs I.

Dr. Börzsei Rita Judit

10 Thyroid hormones, antithyroid drugs II.


11 Hypothalamic and pituitary hormones I.

Dr. Poór Miklós

12 Hypothalamic and pituitary hormones II.

Dr. Poór Miklós


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13 Hypothalamic and pituitary hormones III.

Dr. Poór Miklós

14 Insulin, oral hypoglycemic agents I.

Sánticsné Dr. Pintér Erika

15 Insulin, oral hypoglycemic agents II.


16 Insulin, oral hypoglycemic agents III. Glucagon


17 Parathyroid hormone, calcitonin, vitamin D, and drug treatment of osteoporosis I.


18 Parathyroid hormone, calcitonin, vitamin D, and drug treatment of osteoporosis II.


19 Drugs used in neoplastic diseases I.


20 Drugs used in neoplastic diseases II.


21 Drugs used in neoplastic diseases III.


22 Drugs used in neoplastic diseases IV.


23 Immunosuppressants, immunomodulators


24 Drugs used for treating rheumatoid arthritis


Practices

Seminars

Exam topics/questions

Reqirements: The semester is closed with the final exam. The exams are oral. The required topics are dealt with during the three courses

of Pharmacodynamics, including both lectures and practice classes.The criterion of admission to the exam is the successful

completion of the practice carried out in paralell (midsemester grade with the result different from failed).

Exam questions:

1. Basic mechanisms of drug actions (examples of drug effects on receptors, ion channels, enzymes, carrier systems and effects mediated

by physicochemical interactions)

2. Characterization of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy

3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs

4. Mechanisms of drug antagonisms

5. Transport of drugs across membranes

6. Absorption of drugs, oral bioavailability and presystemic elimination

7. Plasma protein binding and tissue distribution of drugs

8. Biotransformation of drugs

9. Excretion of drugs

10. Pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability,

calculation of loading and maintenance doses

11. Harmful effects of drugs and their mechanisms

12. Factors influencing drug effects: genetic constitution, age, diet, disease

13. Drug interactions

14. Cholinergic agonists and cholinesterase inhibitors

15. Muscarinic receptor antagonists

16. Neuromuscular blocking agents. Drugs acting on autonomic ganglia

17. Agents acting on the biosynthesis, storage, release and elimination of catecholamines

18. Adrenergic receptor agonists

19. Adrenergic receptor antagonists

20. Local anaesthetics

21. Calcium channel blockers

22. Drugs acting on the renin-angiotensin-aldosterone system

23. Diuretic drugs

24. Positive inotropic and other drugs used for treating congestive heart failure

25. Antianginal drugs. Drugs that increase regional blood flow


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26. Antihypertensive drugs

27. Antiarrhythmic drugs

28. Antianxiety and hypnotic drugs

29. Alcohols: pharmacology, toxicology

30. Antipsychotic drugs

31. Antidepressants

32. Central nervous system stimulants. Nootropic drugs

33. Drug treatment of neurodegenerative disorders

34. General anaesthetics

35. Antiepileptic drugs

36. Opioid analgesic drugs: morphine and codeine

37. Opioid analgesic drugs: semisynthetic, synthetic opioids, opioid antagonists

38. Non-steroidal antiinflammatory drugs: aspirin, paracetamol

39. Non-steroidal antiinflammatory drugs: drugs other than aspirin or paracetamol

40. Adjuvant analgesics. Drugs used for treating gout. Centrally-acting muscle relaxants

41. Basic terms of drug abuse. Psychedelics, nicotine, cannabis, inhalants

42. Drugs used for treating hyperlipoproteinaemias

43. Drugs affecting hemostasis

44. Drugs affecting hematopoiesis

45. Histamine, H1 and H2 receptor antagonists

46. Serotonin, serotonin receptor agonists and antagonists. Drug treatment of migraine

47. Pharmacology of eicosanoids. Drugs acting on the smooth muscle: smooth muscle relaxants, pharmacology of the uterine muscle

48. Drugs used in bronchial asthma

49. Drugs used in allergic rhinitis. Antitussive, expectorant and mucolytic agents

50. Drugs used in the treatment of peptic ulcer

51. Emetics, antiemetics and prokinetic drugs. Digestives, drugs used in cholelithiasis

52. Laxatives, antidiarrheal agents, drug treatment of inflammatory bowel diseases

53. Corticosteroids

54. Oestrogens, antioestrogens, progestins, antiprogestins

55. Postmenopausal hormone therapy and hormonal contraceptives

56. Androgens, anabolic steroids, antiandrogens

57. Thyroid hormones, antithyroid drugs

58. Hypothalamic and pituitary hormones

59. Insulin and oral hypoglycemic agents. Glucagon

60. Parathyroid hormone, calcitonin and vitamin D, drugs used for treating osteoporosis

61. Sulphonamides and trimethoprim. Fluoroquinolones. Nitroimidazoles

62. Beta-lactam antibiotics

63. Glycopeptide antibiotics, lipopeptides, polymyxines, gramicidins

64. Aminoglycosides, tetracyclines

65. Macrolide antibiotics , chloramphenicol, lincosamides, streptogramins

66. Antituberculotic drugs. Anti-leprosy drugs

67. Antifungal drugs

68. Antiviral drugs

69. Antiprotozoal drugs

70. Anthelminthic drugs

71. Antiseptics and disinfectants

72. Drugs used in the chemotherapy of neoplastic diseases: alkylating agents, antimetabolites

73. Drugs used in the chemotherapy of neoplastic diseases: alkaloids, antibiotics, hormonal agents

74. Drugs used in the chemotherapy of neoplastic diseases: biological therapy

75. Immunosuppressants and immunomodulators. Drug used to treat rheumatoid arthritis

In addition to the exam topics, an important part of the exam is answering questions that aim at assessing the general knowledge of the

student.

Participants


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OPG-D3G-T PHARMACODYNAMICS 3 - PRACTICE

Course director: DR. GÁBOR ISTVÁN PETHŐ, professor


2 credit ▪ midsemester grade ▪ Pharm. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 9



Topic

The aim of the course is to provide the students with pharmacological knowledge that is required for their future work in the pharmacy.

Important topics are pharmacology of the endocrine system; chemotherapy of microbial diseases including antibacterial, antifungal drugs,

antiviral antiprotozoal, antihelminthic agents, antiseptics and disinfectants; drugs used in chemotherapy of neoplastic diseases;

immunosuppressants, immunomodulators, drug treatment of rheumatoid arthritis. Further topics are pharmacogenetics; effects of age,

diet and diseases on drug action; drug interactions.



Mid-term exams

The students receive a practice mark based on their performance during the semester. The mark will be registered in the NEPTUN. The

mark must be at least satisfactory as a prerequisite for taking the semester exam. Around the 10th week of the semester, a written test is

the base of the parctice mark. The test covers the subjects of practice classes of the first 9 weeks of the semester and 50% of the available

points must be reached for acceptance of the semester. Should someone fail or want to improve, they can do it one time before the end

of the semester. On a final failure (that is, after the improvement attempt still below 50%), the student cannot have semester accepted.


There is no way to make up for missed classes.

Reading material



Electronic handouts are provided for most topics.

- Notes




Lectures

Practices

1 Basic principles of antimicrobial chemotherapy


2 Sulfonamides and trimethoprim


3 Fluoroquinolones, nitroimidazoles


4 Antibiotics impairing the finction of the bacterial cell envelope I


5 Antibiotics impairing the finction of the bacterial cell envelope II


6 Antibiotics impairing the finction of the bacterial cell envelope III


7 Aminoglycosides

Dr. Fliszár-Nyúl Eszter

8 Macrolide antibiotics


9 Tetracyclines, chloramphenicol


10 Linezolide, lincosamides, streptogramines



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11 Antituberculotic drugs

Dr. Poór Miklós

12 Anti-leprosy drugs

Dr. Poór Miklós

13 Antifungal drugs


14 Antiseptics I


15 Antiseptics II


16 Antiviral drugs I

Dr. Kriszta Gábor

17 Antiviral drugs II

Dr. Kriszta Gábor

18 Antiviral drugs III

Dr. Kriszta Gábor

19 Antiprotozoal drugs I.


20 Antiprotozoal drugs II.


21 Anthelminthic drugs I.


22 Anthelminthic drugs II.


23 Pharmacogenetics, pharmacogenomics


24 Effects of age, diet, and disease on drug action. Drug interactions


Seminars


The exam questions are listed in the description of Pharmacodynamics I - Theory course.

Participants

Dr. Börzsei Rita Judit (WYZW6G), Dr. Fliszár-Nyúl Eszter (TUOYWS), Dr. Kriszta Gábor (GDUIJ6), Dr. Pethő Gábor István

(F2YVEE), Dr. Poór Miklós (ARWF5Z)


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OPG-KL2-T CLINICAL STUDIES 2

Course director: DR. RÓBERT GYÖRGY VIDA, assistant professor

Department of Pharmaceutics and University Pharmacy [email protected]

5 credit ▪ semester exam ▪ Pharm. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 9



Topic

The aim of the course is to introduce the most important clinical fields to the pharmacy students. The knowledge related to the most

common disorders, and their non-pharmacological and pharmacological therapies, and also the therapeutic algorithms and regimens are

crucial for the pharmacists nowadays in every therapeutic field from the community pharmacy, hospital and clinical pharmacy to the

clinical research pharmacy as well. The course is closely linked to the pharmacotherapy studies and other clinical oriented subjects in the

9th semester (e.g.: clinical laboratory studies, clinical pharmacy and pharmacotherapy management, forensic pathology and toxicology,

toxicology).



Mid-term exams

There is no mindterm and end-of-the term test.


The abscences should be discussed with the course director.

Reading material



- Notes


Karen J. Tietze. Clinical Skills for Pharmacists. A Patient-Focused Approach, 3rd edition, 2004.

Roger Walker, Cate Whittlesea (eds.): Clinical Pharmacy and Therapeutics, 5th edition, Churchill Livingstone Elsevier, 2012.

Christopher A Langley and Dawn Belcher: Applied Pharmaceutical Practice. Second Edition. Pharmaceutical Press. 2012.

Sally-Anne Francis, Felicity Smith, John Malkinson, Andrew Constanti and Kevin Taylor. Integrated Pharmacy Case Studies.

Pharmaceutical Press, 2015. First edition.

Stephen A. McClave, Denise Baird Schwatrz, Debra S. Kovacevich, Sarah J. Miller. The A. S. P. E. N. Adult Nutrition Support Core

Curriculum, 2nd Edition, 2012.



Lectures

1 Gestation time, pregnancy diagnosis, growth of the uterus during pregnancy. Uncomplicated spontaneous labor. Disorders of

pregnancy: hyperemesis gravidarum, abortion.

Dr. Rácz Sándor Attila

2 Ultrasound examinations during pregnancy. Procedures for assessment of the status of the fetus in utero. Location of the fetus in

utero and its diagnosis.


3 Laying, holding, rotational and integration abnormalities. Natal complications: breech, vacuum forceps, sectio Caesara, preterm

birth, preeclampsia, diabetes and pregnancy, placenta praevia, abruptio placenta, preterm rupture.


4 Contraception. Gynecological inflammations. Sterility testing and management.


5 Cancer screening, gynecologic cancers (cervical and endometrial cancer, ovarian cancer). Benign tumors of the uterus (myoma).


6 Growth and development during childhood.

Dr. Tényiné Dr. Csábi Györgyi

7 Infant nutrition.


8 The bacterial infections in pediatric care practice.



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9 Exsiccatio, fluid replacement, oral rehydration. Antifebrile therapy, treatment of convulsion.


10 Neurological disease symptoms, peripheral and central nervous system disorders.

Dr. Pál Endre

11 Stroke.

Dr. Pál Endre

12 Encephalitis and meningitis, intracranial and spinal tumors.

Dr. Pál Endre

13 Multiple sclerosis, Parkinson’s disease, epilepsy.

Dr. Pál Endre

14 Peripheral nervous system diseases, myopathies.

Dr. Pál Endre

15 Examination of psychiatric patient.

Dr. Tényi Tamás

16 Organic mental disorders.

Dr. Tényi Tamás

17 Endogenous psychoses.

Dr. Tényi Tamás

18 Non-psychotic psychiatric disorders. Psychiatric therapies.

Dr. Tényi Tamás

19 Ear, nose, laryngology. The outer and middle ear.

Dr. Révész Péter

20 The inner ear. Audiological and vestibular basics.

Dr. Bakó Péter

21 The nose.

Dr. Piski Zalán Szabolcs

22 The pharynx.

Dr. Burián András

23 The larynx, trachea, esophagus and neck.

Dr. Burián András

24 Basics of preventive dentistry, pediatric dentistry.

Dr. Balásné Dr. Szántó Ildikó

25 Oral surgery treatments, pain relief.


26 Restorative dental treatments.


27 Basics of prosthodontics.


28 Dental development, orthodontic anomalies, drug-induced dental lesions.


29 Orthopedic examination possibilities, orthopedic screenings, pediatric orthopedic disorders.

Dr. Váncsodi József

30 Large joint diseases and their medical and surgical management


31 Spinal diseases and their conservative and surgical treatment.


32 Joint injuries and their pharmacological and surgical treatment.


33 Orthopedic surgery perioperative complications, prevention, and treatment.


34 Drugs for treatment of urine storage and emptying disorders.

Dr. Damásdi Miklós

35 Medical treatment of uro-oncological diseases.


36 Medical treatment of erectile dysfunction.


37 Medical aids in urological practice.



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38 Urologic clinics of stone diseases and its drugs.


39 The structure of skin, essential phenomena.

Dr. Kinyó Ágnes

40 Infectious skin disease, pyoderma, bacterial, viral and fungal diseases.

Dr. Kinyó Ágnes

41 STD diseases and sexual health care.

Dr. Kinyó Ágnes

42 Dermatological tumors. Immunpathological disorders in dermatology.

Dr. Kinyó Ágnes

43 Eye examination of the patient. (The functional anatomy of the organ of vision, functional and morphological methods of

analysis.)

Dr. Varsányi László Balázs

44 Chronic eye diseases (glaucoma, cataracts, age-related macular degeneration, symptomatology, basic examinations,

interpretation of findings, therapy).


45 Acute ocular diseases. (Symptomatology, basic examinations, interpretation of findings, therapy).


46 Childhood eye diseases. Ocular symptoms of general disorders. Neuroophthalmology.


47 Traumatology in ophthalmology and intraocular tumors.


48 Treatment of spondylarthritis. Treatment of gout. Treatment of infection-triggered arthritis.

Dr. Minier Tünde

49 Non-biological and biological base therapeutic drugs in rheumatoid arthritis.

Dr. Minier Tünde

50 Rules of the utilization of non steroidal antiinflammatory drugs in rheumatology and clinical immunology. Management of acute

and chronical pain in rheumatology.

Dr. Sarlós Gézáné (Dr. Varjú Cecilia)

51 Pharmacological treatment of osteoporosis.

Dr. Sarlós Gézáné (Dr. Varjú Cecilia)

52 Treatment with corticosteroids and cytostatic agents in autoimmun diseases.

Dr. Minier Tünde

53 The primary care of cancer patients, the TNM system, prognostic factors and onkoteam decision.

Dr. Mangel László Csaba

54 The principles and practice of radiochemotherapy.

Dr. Bellyei Szabolcs

55 The clinical implications of chemotherapy.

Dr. Karádi Oszkár

56 Modern targeted therapies and basics of hormone replacement therapy.

Dr. Karádi Oszkár

57 The practice of supportive therapy in oncology.

Dr. Boronkai Árpád

58 Specificity of General Practice, the holistic approach.

Dr. Papp Renáta Emese

59 Physician-pharmacist relationship. Team work. Role-playing.

Dr. Csikós Ágnes Erika

60 GP office and staff. Pharmacist-patient relationship.

Dr. Csikós Ágnes Erika

Practices

Seminars


Written exam is based on the lectures.

The will be 50 single choice questions in the test. Assessment of the student performance is carried out according to a five-grade scale:

100-86,1% - excellent (5); 86-77,1% - good (4); 77-68,1% - satisfactory (3); 68-60,1% - pass (2); and below 60,0% - fail (1) respectively.

Participants


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OPG-KLF-T CLINICAL PHARMACOLOGY

Course director: DR. ERIKA SÁNTICS-PINTÉR, professor

Department of Pharmacology and Pharmacotherapy [email protected]




Topic

In the frame of this one semester subject (15 lectures) students get acquainted with the next clinical pharmacological terms and sections:

history of the drug research, rational drug design, preclinical development, safety pharmacology, clinical studies (Phase I-II-III-IV),

Good Clinical Practice. Documentation of clinical trials. Practical aspects of clinical studies. Evidence-based medicine.



Mid-term exams

None


None

Reading material


None


Lectures made available on Neptun.

- Notes

None


None

Lectures

1 History of drugs


2 History of drugs


3 The process of modern drug development

Dr. Bölcskei Kata

4 Drug discovery

Dr. Hetényi Csaba

5 Drug discovery

Dr. Hetényi Csaba

6 Drug discovery

Dr. Hetényi Csaba

7 Preclinical testing

Dr. Bölcskei Kata


Dr. Bölcskei Kata


Dr. Bölcskei Kata

10 Design and conduct of clinical trials

Dr. Bölcskei Kata


Dr. Bölcskei Kata


Dr. Bölcskei Kata


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13 GMP, GLP, GCP

Dr. Bölcskei Kata

14 GMP, GLP, GCP

Dr. Bölcskei Kata

15 Documentation of the clinical studies

Dr. Bölcskei Kata

Practices

Seminars


Written exam based on the lectures

Participants


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OPG-KLV-T CLINICAL LABORATORY INVESTIGATIONS

Course director: DR. TAMÁS ANTAL KŐSZEGI, professor

Institute of Laboratory Medicine [email protected]




Topic

Clinical Laboratory Investigations is a subject based on a solid knowledge in chemistry, biochemistry and physiology. It gives a practical

guide to understand and interpret a wide variety of modern laboratory tests by showing the molecular basis of them. The subject includes

classic chemical and biochemical methods, immunochemistry, hematology, blood coagulation, toxicology and molecular biology. The

major methodological aspects and applications are discussed during the lectures.



Mid-term exams

One midterm multiple choice is due in October-November

A second midterm multiple choice is due in December

The final grade (mark) is given by evaluation of the combined results of the two midterms


An absence rate of less than 25% is acceptable, no medical or other certificate is necessary.

Reading material


There is no obligatory handbook


All lectures are accessible at Neptun and/or sent by e-mail in pdf form

- Notes

There is no official lecture notes book


W.J. Marshall, S.K. Bangert: Clinical Chemistry, 7th ed., Mosby Co, 2012, ISBN 9780723437048

G.J. Beckett, S.W. Walker, P. Rae, P. Ashby: Lecture Notes on Clinical Biochemistry, 8th ed., Wiley-Blackwell Co., 2013. ISBN

978-1-4443-9475-7

A. Gaw, M.J. Murphy, R.A. Cowan, D.St.J. O’Reilly, M.J. Stewart, J. Shepherd: Clinical Biochemistry, An Illustrated Colour Text,

4th ed., Churchill Livingstone Elsevier 2008

Lectures

1 Clinical Biochemistry: analysis of samples obtained from the human body and interpretation of test results.

Dr. Kőszegi Tamás Antal

2 Different factors influencing the results of lab tests. Informational value of test results (reference intervals, statistical approaches).


3 Different laboratory approaches in water and electrolyte disorders.


4 Internal and external quality controls.


5 Analysis of plasma proteins.

Dr. Horváth-Szalai Zoltán

6 Analysis of plasma proteins.


7 Analysis of plasma enzymes. How enzymes get into the extracellular space?


8 Analysis of plasma enzymes including isoenzymes, significance of enzyme activity measurements.


9 Carbohydrate metabolism and significance of related laboratory tests.

Vassné Lakatos Ágnes


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10 Carbohydrate metabolism and significance of related laboratory tests.

Vassné Lakatos Ágnes

11 Basic principles of blood coagulation and hematological analyses.

Kollárné Kiss Gabriella

12 Basic principles of blood coagulation and hematological analyses.

Kollárné Kiss Gabriella

13 Calcium, magnesium and bone metabolism. Laboratory findings in bone diseases.


14 Calcium, magnesium and bone metabolism. Laboratory findings in bone diseases.


15 Iron, porphyrin and hemoglobin metabolism.


16 Automated immunochemical measurements.


17 Different approaches in liver and gastrointestinal diseases.


18 Tumors and tumor markers.


19 Acid-base balance. Methods and interpretation of test results.

Dr. Szirmay Balázs Gábor

20 Disorders of lipid metabolism.

Dr. Szirmay Balázs Gábor

21 Muscle diseases and analysis of the endocrine system.


22 Muscle diseases and analysis of the endocrine system.


23 Midterm


24 Midterm


Practices

Seminars


In every semester new multiple choice questions are given.

Participants


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OPG-NOV-T HERBAL MEDICINE AND HERBS IN NUTRITION

Course director: DR. NÓRA PAPP, associate professor

Department of Pharmacognosy [email protected]




Topic

The aim of the course is to introduce students to the physiological effects (both beneficial and harmful) of plants and plant drugs

commonly used in nutrition and in phytotherapy. The mode of action, indications, application and typical formulations of plant drugs

used in the treatment of the most important disease types will be demonstrated through case studies. Particular attention will be paid to

the interactions between active compounds of plants and other drugs. The course aims at providing authentic information among the

today so widespread beliefs and misbeliefs, relying on evidence based medicine.



Mid-term exams

Oral exam at the end of the semester.


Management of catch up for absences is possible by personal consultation with the tutor.

Reading material



All lectures are accessible via website of the Department of Pharmacognosy:

http://gytk.pte.hu/en/egyseg/oktatasianyagok/1640

Lectures in Neptun / MS Teams.

- Notes


Aronson J.K. (ed.): Meylers Side Effects of Herbal Medicines, Elsevier, Amsterdam-Oxford-Tokyo, 2009

Barnes J., Anderson L.A., Phillipson J.D.: Herbal Medicines, 2nd edition, Pharmaceutical Press, London-Chicago, 2002

ESCOP Monographs, The Scientific Foundation for Herbal Medicinal Products, 2nd edition, Thieme, Exeter; Stuttgart; New York, 2003

European Medicines Agency guidelines; www.ema.europa.eu

Lectures

1 Ethnopharmacobotany: past and present

Dr. Papp Nóra

2 Ethnopharmacobotany: past and present

Dr. Papp Nóra

3 Major biological effects of herbs used in the human diet; characteristics of an optimal nutritional regime in regard of herbal

constituents of diets

Dr. Farkas Ágnes

4 Plant based dietary supplements using the conception of evidence based medicine; evidences, myths and disbeliefs

Dr. Farkas Ágnes

5 Herbs used in dermatological diseases

Dr. Papp Nóra

6 Medicinal plants in obesity

Dr. Papp Nóra

7 Analgesic herbs and drugs

Dr. Ács Kamilla

8 Medicinal plants used for locomotor diseases

Dr. Ács Kamilla

9 Medicinal plants in the treatment of gastrointestinal diseases

Dr. Ács Kamilla

10 Medicinal plants in the treatment of gastrointestinal diseases

Dr. Ács Kamilla

http://gytk.pte.hu/en/egyseg/oktatasianyagok/1640


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11 Phytotherapy of cardiovascular diseases

Dr. Horváth Adrienn

12 Phytotherapy of cardiovascular diseases


13 Anxiolytic and sedative medicinal plants

Dr. Horváth Györgyi

14 Anxiolytic and sedative medicinal plants


15 Antidiabetic activity of medicinal plants

Dr. Ács Kamilla

16 Hepatoprotective and antiviral herbs


17 Medicinal plants used in the treatment of urogenital diseases

Dr. Papp Nóra

18 Mainstream and complementary therapy of malignant diseases using herbal products

Dr. Farkas Ágnes

19 Herbal products for alleviating complaints connected to the menstrual cycle and menopause

Dr. Farkas Ágnes

20 Phytotherapeutic options for treating benign prostatic hyperplasia

Dr. Farkas Ágnes

21 Phytotherapy for prevention and treatment of common cold

Dr. Csikós Eszter

22 Antihyperlipidemic activity of medicinal plants

Dr. Csikós Eszter

23 Medicinal plant and drug interactions; side effects


24 Medicinal plant and drug interactions; side effects


Practices

Seminars


1. Ethnobotanical methods (field work, data evaluation); evaluation of relevant sources and literature

2. Role of food plants in the optimal diet

3. Critical evaluation of dietary supplements of plant origin

4. Sedative, antidepressant and analgesic herbs

5. Herbs for alleviating complaints of the genital tracts and the hormonal system

6. Herbs for bone and joint diseases

7. Herbs for respiratory disorders

8. Herbs to control the cholesterol level

9. Herbs for gastrointestinal disorders

10. Hepatoprotective and antiviral herbs

11. Antidiabetic herbs

12. Herbs for urogenital disorders

13. Herbs for dermatological diseses

14. Herbs for cardiovascular disorders

15. Herbs used in obesity

16. Mainstream and complementary therapy of malignant diseases using herbs

17. Interactions of phytotherapy and nutrition

Participants


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OPG-PRG-T PROBLEMSOLVING PHARMACY

Course director: DR. ERIKA SÁNTICS-PINTÉR, professor

Department of Pharmacology and Pharmacotherapy [email protected]




Topic

Training for the practical aspects of the pharmacist praxis. Discussions of the case reports.



Mid-term exams

None


None

Reading material



Lecture notes made available on Neptun.

- Notes


Lectures

1 Drug therapy problems of cardiovascular diseases, (palpitations, chest pain, edema, dizziness, weakness, headache)


2 Drug therapy problems of cardiovascular diseases, (palpitations, chest pain, edema, dizziness, weakness, headache)


3 Tasks of the pharmacist in the treatment of diabetes


4 Drug treatment of gastrointestinal disorders (anorexia, vomiting, diarrhea, constipation, abdominal pain, bloody stools)


5 Drug treatment of gastrointestinal disorders (anorexia, vomiting, diarrhea, constipation, abdominal pain, bloody stools)


6 Pharmacotherapeutic problems of respiratory diseases (cough, runny nose, shortness of breath, wheezing, chest pain)

Dr. Faisal Anna Zelma

7 Pharmaceutical problems of coagulation disorders (warfarin, heparin therapy, interactions, bleeding)


8 Neurological diseases pharmacotherapy problems: (dizziness, headache, tinnitus, loss of consciousness, pain, paralysis)

Dr. Bölcskei Kata

9 Neurological diseases pharmacotherapy problems: (dizziness, headache, tinnitus, loss of consciousness, pain, paralysis)

Dr. Bölcskei Kata

10 The specific pharmacological problems of pediatrics 1


11 The specific pharmacological problems of pediatrics 2


12 Inflammatory, allergic diseases

Dr. Mohos Violetta Karolin

13 Anxiety, depression, drug abuse


14 Support of the antidepressant therapy by the pharmacist


15 Pharmacological problems of pain management 1

Dr. Bölcskei Kata


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16 Pharmacological problems of pain management 2

Dr. Bölcskei Kata

17 Problem solving in the current scope of antimicrobial therapy 1

Dr. Vida Róbert György

18 Problem solving in the current scope of antimicrobial therapy 2


19 Medication problems during pregnancy and lactation

Dr. Fittler András Tamás

20 Contraception, therapeutic use of drugs for treatment of genitals


21 Drugs used for treatment of sensory organs


Practices

Seminars


Written exam based on the lectures.

1. Drug therapy problems of cardiovascular diseases, (palpitations, chest pain, edema, dizziness, weakness, headache)

2. Medical treatment of gastrointestinal disorders (anorexia, vomiting, diarrhea, constipation, abdominal pain, bloody stools)

3. Pharmacotherapeutic problems of respiratory disease (cough, runny nose, shortness of breath, wheezing, chest pain)

4. Pharmaceutical problems affecting coagulation disorders (warfarin, heparin therapy, interactions, bleeding)

5. Neurological diseases pharmacotherapy problems: (dizziness, headache, tinnitus, loss of consciousness, pain, paralysis)

6. The specific pharmacological problems of pediatrics

7. Inflammatory, allergic diseases

9. Anxiety, depression, drug abuse

10. Problems of pharmacological pain management

11. Problem solving in the current scope of antimicrobial therapy

12. Applications of dermatological preparations (rash, itching, peeling, dermatitis, wound care, dry skin)

13. Arising medication problems during pregnancy and lactation. Contraception, therapeutic use of drugs for treatment of genitals.

14. Drugs used for treatment of sensory organs.

Participants


19

OPG-SIE-T PHARMACEUTICAL INFORMATICS - THEORY

Course director: DR. LAJOS BOTZ, professor





Topic

During the semester the students will become familiar with the basics of personal computer and network systems in general and with the

specifications of pharmaceutical informatics, such as the development and stages of pharmacy informatics, principles of pharmacy

software. Also the different software types and drug dispensing rules used in pharmacies are introduced in this semester. The basic

knowledge of drug interactions and the available techniques and databases for screening interactions in everyday practice is also an

emphasized topic. After acquiring the principles of informatics and pharmaceutical informatics the students will be able to synthesize the

elements and understand the functions of pharmacy information management systems. Even the possibilities and threats of online drug

marketing and the capability of finding relevant and authentic pharmaceutical information on the web is the objective of this course.


Acceptance of term/semester:

- Regular attendance of classes

- Assignments given in class should be carried out during term-time and,

- Written mid-term and end-of-the term test. Passing the midterm test is not obligatory; however advisable as you will likely

have better results during the exam and a good practical grade for the course.There is a retake opportunity only for the end-of-the term

test.

Mid-term exams

End-of-the-term test is at the regular time of lectures. The test will be on the whole semester’s curriculum. Additional questions can be

included in the end-of-the-term test, if the student has not carried out an assignment during the semester or in case of unsuccessful

midterm test.

In case of unsuccessful or missed end-of-the term test, a retake opportunity is granted to make up during the last week of the semester.

Assessment of the student performance is carried out according to a five-grade scale:100-86,1% -excellent (5); 86-77,1% -good (4); 77-

68,1% -satisfactory (3); 68-60,1% -pass (2); and below 60,0% -fail (1) respectively.


Retake opportunity is possible following personal discussion for the end-of-the term test.

Reading material



List of study aids to acquire curriculum (books, notes, other) and all presentations can be downloaded from Neptun MeetStreet.

- Notes


Ed. R. Fisher: Information Technology for Pharmacists, Pharmaceutical Press

Brent I. Fox, Margaret R. Thrower, Bill G. Felkey: Building Core Competencies in Pharmacy Informatics, American Pharmacists

Association, 2010

Lectures

1 Personal computer and network system fundamentals 1.


2 Personal computer and network system fundamentals 2.


3 Database systems, IT and search engines 1.


4 Database systems, IT and search engines 2.


5 Drug interactions, Drug interaction databases 1.

Dr. Somogyi-Végh Anna




20

7 Midterm test






10 Pharmaceutical Information Management Systems 1.




12 End-of-the term test


Practices

Seminars


In case of Pharmaceutical Informatics there is mid-semester grade for both the theory and practice part, based on the topics discussed.

PharmInfo practical course grade is based upon the completion of the given assignments, individual/group tasks and the mid-term

test. Theory grade for Pharm. Informatics is based on the end-of-the-term test (or it’s retake) result. Additional dates for retake are

offered during the fist two weeks of the exam period.

Participants


21

OPG-SIG-T PHARMACEUTICAL INFORMATICS - PRACTICE






Topic

During the semester the students will become familiar with the basics of personal computer and network systems in general and with the

specifications of pharmaceutical informatics, such as the development and stages of pharmacy informatics, principles of pharmacy

software. Also the different software types and drug dispensing rules used in pharmacies are introduced in this semester. The basic

knowledge of drug interactions and the available techniques and databases for screening interactions in everyday practice is also an

emphasized topic. After acquiring the principles of informatics and pharmaceutical informatics the students will be able to synthesize the

elements and understand the functions of pharmacy information management systems. Even the possibilities and threats of online drug

marketing and the capability of finding relevant and authentic pharmaceutical information on the web is the objective of this course.



- Regular attendance of classes


- Written mid-term and end-of-the term test. Passing the midterm test is not obligatory; however advisable as you will likely have better

results during the exam and a good practical grade for the course.There is a retake opportunity only for the end-of-the term test.

Mid-term exams



midterm test.


Assessment of the student performance is carried out according to a five-grade scale: 100-86,1% -excellent (5); 86-77,1% -good (4); 77-




Reading material



List of study aids to acquire curriculum (books, notes, other) and all presentations can be downloaded from Neptun MeetStreet.

- Notes


Ed. R. Fisher: Information Technology for Pharmacists, Pharmaceutical Press

Brent I. Fox, Margaret R. Thrower, Bill G. Felkey: Building Core Competencies in Pharmacy Informatics, American Pharmacists

Association, 2010

Lectures

Practices

1 Evidence Based Medicine - Critical Appraisal.


2 Evidence Based Medicine: Outcome Measures.


3 Evidence Based Medicine: Calculations.


4 Evidence Based Medicine: Interpretation of results. Practice


5 Central Clinical Pharmacy Oncology laboratory visit 1.



22

6 Central Clinical Pharmacy Oncology laboratory visit 2.


7 Midterm test


8 UNIV Pharmacy On site visit 1.


9 UNIV Pharmacy On site visit 2.






12 End-of-the term test


Seminars


In case of Pharmaceutical Informatics there is mid-semester grade for both the theory and practice part, based on the topics discussed.

PharmInfo practical course grade is based upon the completion of the given assignments, individual/group tasks and the mid-term

test. Theory grade for Pharm. Informatics is based on the end-of-the-term test (or it’s retake) result. Additional dates for retake are

offered during the first two weeks of the exam period.

Participants

Dr. Fittler András Tamás (IYR5HQ), Dr. Vida Róbert György (BN08GS)


23

OPG-TXA-T TOXICOLOGY

Course director: DR. MIKLÓS POÓR, assistant professor





Topic

Toxicology as a subject deals with the toxic (including teratogenic and carcinogenic) effects of drugs and xenobiotics (metals, solvents,

toxic gases, pesticides, mushroom- and plant-derived toxins, etc.) caused by overdose or excessive exposure. It describes the general

aspects of toxicology, the mechanisms of toxicity (including the major influencing factors), the harmful effects and the corresponding

symptoms, the diagnostics of the adverse health effects, as well as their prevention and treatment. In addition, toxicity testing and risk

assessment of chemicals are also shortly discussed.



Mid-term exams

Students are required to take two mid-semester written tests, which are scheduled for weeks 7 and 14, approximately. These tests will

contain multiple choice and short essay type questions. The average score of these two mid-semester tests (%) will be evaluated. We will

offer a final grade for those reaching a mid-term result of at least 70%. On the other hand, those not achieve the 50% limit in the mid-

term tests will get two extra topics during their oral exam.


Missed classes cannot be made up.

Reading material



Slides of each lecture will be available for the students on Neptun Meet Street.

- Notes


Casarett & Doull's Toxicology, 9th edition, McGraw-Hill, 2019.

Lectures

1 Basic principles of toxicology.

Dr. Poór Miklós

2 Human intoxications: Occurrence and classification. Causes of poisoning-related death.

Dr. Poór Miklós

3 Management of the poisoned patient I. - Emergency care, diagnostics, antidotes.

Dr. Poór Miklós

4 Management of the poisoned patient II. - Decontamination, enhancement of the elimination of toxicants, supportive treatment.

Dr. Poór Miklós

5 Drug intoxications I. - Drugs decreasing consciousness.

Dr. Poór Miklós

6 Drug intoxications II. - Drugs causing agitation.

Dr. Poór Miklós

7 Drug intoxications III. - Drugs causing cardiac dysfunction.

Dr. Poór Miklós

8 Drug intoxications IV. - Drugs causing metabolic disorder or tissue necrosis.

Dr. Poór Miklós

9 Toxic hypoxias I. - Toxic gases (carbon monoxide, hydrogen cyanide and cyanogen compounds, hydrogen sulfide).

Dr. Poór Miklós

10 Toxic hypoxias II. - Methemoglobin formers.

Dr. Poór Miklós

11 Toxicology of solvents I. - General properties, hydrocarbons and their halogenated derivatives.

Dr. Poór Miklós


24

12 Toxicology of solvents II. - Alcohols and carbon disulfide.

Dr. Poór Miklós

13 Toxicology of metals I. - General properties, protective mechanisms, metal chelators.

Dr. Poór Miklós

14 Toxicology of metals II. - Lead, mercury, cadmium, and arsenic.

Dr. Poór Miklós

15 Toxicology of pesticides I. - General properties, insecticides, herbicides.

Dr. Poór Miklós

16 Toxicology of pesticides II. - Fungicides, rodenticides, fumigants.

Dr. Poór Miklós

17 Poisonous mushrooms.

Hartnerné Dr. Pohóczky Krisztina

18 Chemical warfare agents.


19 Chemical carcinogenesis I. - Historical examples, genotoxic carcinogens.


20 Chemical carcinogenesis II. - Non-genotoxic carcinogens, the process of carcinogenesis.


21 Chemical teratogenesis I. - Historical examples, human chemical teratogens.


22 Chemical teratogenesis II. - Teratogenic drugs, developmental toxicology.


23 Toxicity testing.


24 Risk assessment.


25 Summary, consultation I.

Dr. Poór Miklós

26 Summary, consultation II.

Dr. Poór Miklós

27 -

Dr. Poór Miklós

28 -

Dr. Poór Miklós

29 -

Dr. Poór Miklós

30 -

Dr. Poór Miklós

Practices

Seminars


The exam includes each topic discussed during the lectures and presented in lecture slides (available in Neptun Meet Street). Those have

not achieved at least 70% in mid-term tests have to take an oral exam (during the exam period). In addition to the exam topics, an

important part of the exam is answering questions that aim at assessing the general knowledge of the student. Students have to discuss

in details two major exam questions; however, those who did not achieve 50% in the mid-term tests need to explain two additional

topics as well.

Exam topics/questions:

1. The scope of toxicology. Human intoxications: occurrence and classification. Causes of poisoning-related death.

2. Management of the poisoned patient: emergency care, diagnostics, decontamination, antidotes, enhancement of the elimination of

toxicants, supportive care.

3. Drug intoxications I: drugs decreasing consciousness, drugs causing agitation.

4. Drug intoxications II: drugs causing cardiac dysfunction, metabolic disorders, or tissue necrosis.

5. Toxic hypoxias: carbon monoxide, hydrogen cyanide and cyanogen compounds, hydrogen sulfide, methemoglobin formers.

6. Toxicology of solvents: hydrocarbons and their halogenated derivatives, alcohols, carbon disulfide.

7. Toxicology of metals: metal chelators, protective mechanisms, toxic effects of metals.

8. Toxicology of pesticides: general properties, insecticides, herbicides, fungicides, rodenticides, and fumigants.

9. Poisonous mushrooms.

10. Chemical warfare agents.


25

11. Chemical carcinogenesis.

12. Xenobiotic-induced fetal malformations.

13. Toxicity testing and risk assessment.

Participants


26

OPG-U4E-T PHARMACEUTICAL PRACTICE AND MANAGEMENT 3 - THEORY



2 credit ▪ final exam ▪ Pharm. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 9



Topic

The lectures of the semester will further outline the pharmaceutical supply system, specific pharmacy practice knowledge in community

and clinical professional pharmaceutical practice and care. Students will acquire skills in finding, evaluating and interpreting reliable

pharmaceutical information by getting familiar with the concepts of evidence based medicine and pharmacy informatics. In this semester

also interactive discussions will cover essential topics regarding self-medication, patient counselling and over the counter products used

in minor diseases. Detailed discussion of pharmacy practice will cover personal and objective criteria of pharmacies, prescribing and

dispensing regulations, controlled drugs, ordering and stockpiling drugs. Ensuring medication safety in community and hospital

pharmacy setting is a key element of modern pharmaceutical practice, thus the lectures focus on relevant issues. Students will discuss

elements of ethical behavior and pharmacy ethics in practice.

Students can access the slides of the lectures and further reading material on a designated web based interface (e.g. MS Teams and/or

Neptun Meet Street).



- Regular attendance of classes (maximum 25 % of absence is accepted),


- Written mid-term and end-of-the term test. Passing the tests is not obligatory; however advisable as you will likely have better results

during the exam and a good practical grade for PPM3. There is a retake opportunity only for the end-of-the term test.

Mid-term exams



midterm test.




PPM3 practical course grade is based upon the completion of the given assignments, self-care and nonprescription pharmacotherapy

module and the mid-term test. Theory grade for PPM3 is based the oral exam during the exam period (see list of Final exam topics 1-

50).



Reading material



List of study aids to acquire curriculum (books, notes, other) and all presentations can be downloaded from MS teams and/or Neptun

MeetStreet.

- Notes

További ajánlott irodalmak:

ASHP: Handbook on Injectable Drugs. 19th edition

Karen J. Tietze: Clinical Skills for Pharmacists: A Patient-Focused Approach. Mosby; 3rd edition

Min Liu, Lakesha M. Butler: Patient Communication For Pharmacy: A Case-Study Approach on Theory and Practice. Jones &

Bartlett Learning; 1 Pap/Psc edition

Sally-Anne Francis, Felicity Smith, John Malkinson, Andrew Constanti, Kevin Taylor: Integrated Pharmacy Case Studies.

Pharmaceutical Press; 1st edition


C. Bond (ed.): Evidence-based Pharmacy, Pharmaceutical Press, London, 2002.

A. J. Winfield, R. M. E. Richards (eds.): Pharmaceutical Practice, Churchill Livinstone

C. H. Knowlton, R. P. Penna (eds.): Pharmaceutical Care, ASHSP


27

M. Stephens (ed.): Hospital Pharmacy, Pharmaceutical Press, London, 2006.

Rosemary R. Berardi, Stefanie P. Ferreri et al.: Handbook of Nonpresciption Drugs, 17th edition, American Pharmacists Association, 2012.

Walker, Roger: Clinical Pharmacy and Therapeutics, 2011.

Edzard Ernst, Simon Singh: Trick or Treatment, W. W. Norton & Company, 2008. Section IV: Nutrition and Nutritional

Supplementation, Section XI: Complementary and Alternative Medicine.

Edzard Ernst, Simon Singh: Trick or Treatment? Alternative Medicine on Trial

John P. Griffin, John Posner, Geoffrey R. Barker: The Textbook of Pharmaceutical Medicine, 7th Edition, 2013.

Paul Rutter: Community Pharmacy - Symptoms, Diagnosis and Treatment 4th Edition. Elsevier 2017

Lectures

1 (PharmPract1) Personal and objective criteria for pharmacies. 1


2 (PharmPract2) Personal and objective criteria for pharmacies. 2


3 (PharmPract4) Monitoring Medication Safety in the framework BPC guideline


4 (PharmPract5) Controlled drugs - prescribing and dispensing regulations and procedures.


5 (PharmPract7) Ordering, procurement, stockpiling and storage of various products in community pharmacies


6 (HospPharCare1) Clinical pharmacy services 1.

Dr. Vincze Patricia Anna

7 (HospPharCare3) Pharmaceutical care – Life stages: Pediatrics.


8 (HospPharCare4) Pharmaceutical care – Life stages: Geriatrics.

Dr. Bella Richárd

9 (Ethics1) Introduction, basics of ethics, ethical issues in clinical trials, placebo effect and its ethical concerns


10 (Ethics2) The ethics of patient-pharmacist relationship, ethical communication, ethical dilemmas of special areas (abortion,

mental illnesses, etc.)


11 (HospPharCare5) Pharmaceutical care – Life stages: Pregnancy and lactation.


12 (HospPharCare6) Nutrition therapy


13 (HospPharCare7) Volume therapy.


14 Midterm test


15 (EBM1) Evidence Based Medicine: Introduction.


16 (EBM2) Pyramid of Evidence Resources.


17 (HospPharCare8) Oncology pharmacy practice.


18 (HospPharCare9) Oncology pharmacy practice.


19 (HospPharCare10) Patient safety in clinical practice.


20 (HospPharCare11) Application of pharmaco-economics (SOJA, decision tree) in hospital practice.

Dr. Bella Richárd

21 (EBM4) Evidence Based Medicine: Databases.


22 (HospPharCare12) Pharmaceutical Care in Infectology.


23 Revision of semester's topics


24 Final test



28

Practices

Seminars


Examination and granting of grades: for Pharmaceutical Practice and Management 3 students must take an oral final exam.

Final exam topics for PHARMACEUTICAL PRACTICE AND MANAGEMENT

(Basic principles of pharmacy and Pharmaceutical practice and management 1, 2 & 3)

Three exam topics shall be elaborated and presented during the final exam. Supplementary definitions and questions (which will not be

highlighted during the exam) below the listed exam titles aim to specify the required knowledge for each topic. Certain contents of

the discussed topics may be overlapping, while other exam topics require the association of professional pharmaceutical knowledge

introduced during different lectures/semesters.

1. History of Pharmacy and Medicine. Pharmacy as a profession.

2. Development and role of Pharmacopoeias and formularies in pharmacy.

3. Product categories in community pharmacies.

4. Regulation and organization of Hungarian health system.

5. The drug supply chain, stakeholders of the drug supply system.

6. Personal and objective criteria for community, branch and single-handed pharmacies in Hungary.

7. Regulation of the prescribing and dispensing of medicines in Hungary.

8. Regulation regarding controlled drugs in Hungary. International drug control treaties.

9. International and Hungarian health and pharmaceutical organizations.

10. Fundamentals of economics for pharmacists. Characteristics of market of healthcare and pharmaceuticals.

11. Health Economics and Pharmacoeconomics I.: Aims, methodology and the main methods.

12. Health Economics and Pharmacoeconomics II.: The concept, importance and measurement of the quality of life.

13. Drug utilization. Drug classification systems.

14. Rational and transparent drug selection. SOJA method. Decision Analysis.

15. Pricing and life cycle of drugs.

16. Health expenditures, drug/healthcare costs, cost-control techniques.

17. Development and types of social and health insurance systems. Characteristics of the Hungarian social and health insurance system.

18. Basics and practice of Marketing.

19. Drug Research and Development I.: Pre-clinical phase.

20. Drug Research and Development II.: Clinical trials.

21. Drug Research and Development III.: Phases in clinical trials.

22. Drug authorization process I.: Patent protection.

23. Drug authorization processes II.: Abridged authorization. Off-label use of drugs. Orphan drugs.

24. Drug authorization processes III.: Equivalencies of drugs. Substitution.

25. Placebo effect: the role of placebo in clinical trials and therapy.

26. Patient Rights.

27. Medication errors.

28. Adverse drug reactions.

29. Drug interactions.

30. Philosophy and development of evidence based medicine and pharmacy.

31. Hierarchy of medical information and clinical evidence, clinical study designs.

32. The practical steps of evidence based practice.

33. Interpreting the results of evidence based practice: Outcome measures.

34. Hospital and clinical pharmacy I.: Life stages (pediatrics, geriatrics, gravidity and breast feeding).

35. Hospital and clinical pharmacy II.: Infectology and antibiotic stewardship.

36. Hospital and clinical pharmacy III.: Nutrition therapy. Fluid therapy.

37. Hospital and clinical pharmacy IV.: The development and services of hospital and clinical pharmacy.

38. Hospital and clinical pharmacy V.: Oncology pharmacy.

39. The development, basics and techniques of pharmaceutical care.

40. Pharmaceutical care of respiratory diseases: allergic rhinitis, asthma bronchiale, COPD.

41. Pharmaceutical care of cardiometabolic syndrome

42. Self-Care and Nonprescription Pharmacotherapy I.: Patient assessment and consultation.

43. Self-Care and Nonprescription Pharmacotherapy II.: Dry skin, atopic dermatitis, acne, contact dermatitis and allergy.

44. Self-Care and Nonprescription Pharmacotherapy III.: Dyspepsia, heartburn and intestinal gas, diarrhea and constipation.

45. Self-Care and Nonprescription Pharmacotherapy IV.: Fungal skin infections, vaginal and vulvovaginal disorders.


29

46. Self-Care and Nonprescription Pharmacotherapy V.: Headache, fever, cough and disorders related to colds.

47. Self-Care and Nonprescription Pharmacotherapy VI.: Oral disorders, nutritional supplementation.

48. Good Communication in Pharmacy Practice. Written, electronic communication in Health care and holding oral presentations.

49. Medication adherence - Helping patients manage therapeutic regimens.

50. Pharmaceutical informatics.

Participants


30

OPG-U4G-T PHARMACEUTICAL PRACTICE AND MANAGEMENT 3 - PRACTICE






Topic

The lectures of the semester will further outline the pharmaceutical supply system, specific pharmacy practice knowledge in community

and clinical professional pharmaceutical practice and care. Students will acquire skills in finding, evaluating and interpreting reliable

pharmaceutical information by getting familiar with the concepts of evidence based medicine and pharmacy informatics. In this semester

also interactive discussions will cover essential topics regarding self-medication, patient counselling and over the counter products used

in minor diseases. Detailed discussion of pharmacy practice will cover personal and objective criteria of pharmacies, prescribing and

dispensing regulations, controlled drugs, ordering and stockpiling drugs. Ensuring medication safety in community and hospital

pharmacy setting is a key element of modern pharmaceutical practice, thus the lectures focus on relevant issues. Students will discuss

elements of ethical behavior and pharmacy ethics in practice.

Students can access the slides of the lectures and further reading material on a designated web based interface (e.g. MS Teams and/or

Neptun Meet Street).



- Regular attendance of classes (maximum 25 % of absence is accepted),


- Written mid-term and end-of-the term test. Passing the tests is not obligatory; however advisable as you will likely have better results

during the exam and a good practical grade for PPM3. There is a retake opportunity only for the end-of-the term test.

Mid-term exams



midterm test.




PPM3 practical course grade is based upon the completion of the given assignments, self-care and nonprescription pharmacotherapy

module and the mid-term test. Theory grade for PPM3 is based the oral exam during the exam period (see list of Final exam topics 1-

50).



Reading material



List of study aids to acquire curriculum (books, notes, other) and all presentations can be downloaded from MS teams and/or Neptun

MeetStreet.

- Notes

További ajánlott irodalmak:

ASHP: Handbook on Injectable Drugs. 19th Edition

Karen J. Tietze: Clinical Skills for Pharmacists: A Patient-Focused Approach. Mosby; 3rd edition

Min Liu, Lakesha M. Butler: Patient Communication For Pharmacy: A Case-Study Approach on Theory and Practice. Jones &

Bartlett Learning; 1 Pap/Psc edition

Sally-Anne Francis, Felicity Smith, John Malkinson, Andrew Constanti, Kevin Taylor: Integrated Pharmacy Case Studies.

Pharmaceutical Press; 1st edition


C. Bond (ed.): Evidence-based Pharmacy, Pharmaceutical Press, London, 2002.

A. J. Winfield, R. M. E. Richards (eds.): Pharmaceutical Practice, Churchill Livinstone

C. H. Knowlton, R. P. Penna (eds.): Pharmaceutical Care, ASHSP


31

M. Stephens (ed.): Hospital Pharmacy, Pharmaceutical Press, London, 2006.

Rosemary R. Berardi, Stefanie P. Ferreri et al.: Handbook of Nonpresciption Drugs, 17th edition, American Pharmacists Association,

2012.

Walker, Roger: Clinical Pharmacy and Therapeutics, 2011.

Edzard Ernst, Simon Singh: Trick or Treatment, W. W. Norton & Company, 2008. Section IV: Nutrition and Nutritional

Supplementation, Section XI: Complementary and Alternative Medicine.

Edzard Ernst, Simon Singh: Trick or Treatment? Alternative Medicine on Trial

John P. Griffin, John Posner, Geoffrey R. Barker: The Textbook of Pharmaceutical Medicine, 7th Edition, 2013.

Paul Rutter: Community Pharmacy - Symptoms, Diagnosis and Treatment 4th Edition. Elsevier 2017

Lectures

Practices

1 (PharmPract3) Assuring medication safety in community pharmacy practice


2 (PharmPract6) Detailed introduction to the dispensing practice


3 (HospPharCare2) Clinical pharmacy services 2.


4 (OTC1) Allergy and contact dermatitis


5 (OTC2) Headache and migraine


6 (OTC3) Vaginal and vulvovaginal disorders


7 Midterm test


8 (EBM3) Evidence Based Medicine: Questioning.


9 (OTC4) Cough and expectorants. Disorders related to cold, fever


10 (OTC5): Fungal skin, Athelete's foot

Dr. Bella Richárd

11 (OTC6) Dyspepsia, Heart burn


12 (OTC7) Diarrhea and constipation


Seminars


Examination and granting of grades: for Pharmaceutical Practice and Management 3 students must take an oral final exam.

Final exam topics for PHARMACEUTICAL PRACTICE AND MANAGEMENT

(Basic principles of pharmacy and Pharmaceutical practice and management 1, 2 & 3)

Three exam topics shall be elaborated and presented during the final exam. Supplementary definitions and questions (which will not be

highlighted during the exam) below the listed exam titles aim to specify the required knowledge for each topic. Certain contents of

the discussed topics may be overlapping, while other exam topics require the association of professional pharmaceutical knowledge

introduced during different lectures/semesters.

1. History of Pharmacy and Medicine. Pharmacy as a profession.

2. Development and role of Pharmacopoeias and formularies in pharmacy.

3. Product categories in community pharmacies.

4. Regulation and organization of Hungarian health system.

5. The drug supply chain, stakeholders of the drug supply system.

6. Personal and objective criteria for community, branch and single-handed pharmacies in Hungary.

7. Regulation of the prescribing and dispensing of medicines in Hungary.

8. Regulation regarding controlled drugs in Hungary. International drug control treaties.

9. International and Hungarian health and pharmaceutical organizations.

10. Fundamentals of economics for pharmacists. Characteristics of market of healthcare and pharmaceuticals.

11. Health Economics and Pharmacoeconomics I.: Aims, methodology and the main methods.


32

12. Health Economics and Pharmacoeconomics II.: The concept, importance and measurement of the quality of life.

13. Drug utilization. Drug classification systems.

14. Rational and transparent drug selection. SOJA method. Decision Analysis.

15. Pricing and life cycle of drugs.

16. Health expenditures, drug/healthcare costs, cost-control techniques.

17. Development and types of social and health insurance systems. Characteristics of the Hungarian social and health insurance system.

18. Basics and practice of Marketing.

19. Drug Research and Development I.: Pre-clinical phase.

20. Drug Research and Development II.: Clinical trials.

21. Drug Research and Development III.: Phases in clinical trials.

22. Drug authorization process I.: Patent protection.

23. Drug authorization processes II.: Abridged authorization. Off-label use of drugs. Orphan drugs.

24. Drug authorization processes III.: Equivalencies of drugs. Substitution.

25. Placebo effect: the role of placebo in clinical trials and therapy.

26. Patient Rights.

27. Medication errors.

28. Adverse drug reactions.

29. Drug interactions.

30. Philosophy and development of evidence based medicine and pharmacy.

31. Hierarchy of medical information and clinical evidence, clinical study designs.

32. The practical steps of evidence based practice.

33. Interpreting the results of evidence based practice: Outcome measures.

34. Hospital and clinical pharmacy I.: Life stages (pediatrics, geriatrics, gravidity and breast feeding).

35. Hospital and clinical pharmacy II.: Infectology and antibiotic stewardship.

36. Hospital and clinical pharmacy III.: Nutrition therapy. Fluid therapy.

37. Hospital and clinical pharmacy IV.: The development and services of hospital and clinical pharmacy.

38. Hospital and clinical pharmacy V.: Oncology pharmacy.

39. The development, basics and techniques of pharmaceutical care.

40. Pharmaceutical care of respiratory diseases: allergic rhinitis, asthma bronchiale, COPD.

41. Pharmaceutical care of cardiometabolic syndrome

42. Self-Care and Nonprescription Pharmacotherapy I.: Patient assessment and consultation.

43. Self-Care and Nonprescription Pharmacotherapy II.: Dry skin, atopic dermatitis, acne, contact dermatitis and allergy.

44. Self-Care and Nonprescription Pharmacotherapy III.: Dyspepsia, heartburn and intestinal gas, diarrhea and constipation.

45. Self-Care and Nonprescription Pharmacotherapy IV.: Fungal skin infections, vaginal and vulvovaginal disorders.

46. Self-Care and Nonprescription Pharmacotherapy V.: Headache, fever, cough and disorders related to colds.

47. Self-Care and Nonprescription Pharmacotherapy VI.: Oral disorders, nutritional supplementation.

48. Good Communication in Pharmacy Practice. Written, electronic communication in Health care and holding oral presentations.

49. Medication adherence - Helping patients manage therapeutic regimens.

50. Pharmaceutical informatics.

Participants

Dr. Bella Richárd (IL65ZJ), Dr. Fittler András Tamás (IYR5HQ), Dr. Somogyi-Végh Anna (CPFSLI), Dr. Vida Róbert György

(BN08GS), Dr. Vincze Patricia Anna (XE52I7)


33

OPS-ZG1-T PROFESSIONAL PRACTICE BEFORE STATE EXAMINATION 1

Course director: DR. PÉTER KÁSA, senior research fellow

Institute of Pharmaceutical Technology and Biopharmacy [email protected]

8 credit ▪ midsemester grade ▪ Final/Rotational (year) subject ▪ autumn semester ▪ recommended semester: 9



The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

Two months of the course of Pharmacy Practice 3 is the first part of the 6 months of practice in the rigorous year. The aim of the first

part is to expand the knowledge and approach of students with practice-oriented pharmaceutics, knowing the aspects of pharmaceutical

care, economy, and preparing magistral medicines in the pharmacy.

The 6 months are the 6 thematics, from this 1-3 parts must in the 2 months 2 part in the Professional Practice Before state Examination

I.

The practice 2 months can be homeland or Hungarian or foreign countries pharmacy.

Letter of Acceptance submission deadline 30. April.


Brief daily report must be done during the practice which has to be presented. Tutor pharmacist and chief pharmacist has to evaluate

students work and confirm the pharmacy practice with their signature. Student must work daily 8 hours during two month of practice.

Proposal in the Hungarian pharmacy practice with Hungarian Student together.

Mid-term exams




During the 6 months practice only 5 days are allowed to miss confirmed by a physician. More days of missing must be supplemented.

Reading material


Dévay: The Theory and Practice of Pharmaceutical Technology, e-book, http://gytsz.pte.hu/en/egyseg/oktatasianyagok/1620/


- Notes

Final exam - test-book,

White coat, Protective shoes


European Pharmacopoeia

Pharmacopoeia Hungarica

Hungarian National Formulary: Formulae Normales VII (FoNo VII)

Compendium

Lectures

Practices

1.a) Clinical Pharmacy 1. parts

Knowing the structure of hospital/clinic

Studying the relationship between the pharmacy and other wards

Controlling role of the pharmacy regarding drug utilization and storage of different wards

Federal laws affecting clinical pharmacy practice

Preparing drugs specified for clinical pharmacies under the supervision of the tutor pharmacist

Knowing and operating with special appliances on different divisions (galenic division, parenteral division) of the pharmacy

under the supervision of the tutor pharmacist

Knowing basic galenic preparations of the pharmacy containing knowledge of preparation of infusions, peritoneal dialysis

solutions; knowing the conditions for preparations, analytical and microbiological control methods and storage

Recognizing and repairing incompatibilities

Participating in economical tasks of the pharmacy

Pharmaceutical economy, ordering medicines


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Studying drugs, medical aids, nutritions, diagnostics, x-ray contrast materials stored in pharmacy

Studying relationship with pharmaceutical manufacturers and distributors

Studying drug order from foreign countries

Treatment of drugs and ingredients of increased control

Studying participation of the pharmacy in the therapy

Knowing the intelligence service of the pharmacy

Studying role and function of Board of Pharmaceutical Therapy, knowing its protocols

Studying drug development clinical trials, knowing the documentation, federal laws regarding clinical trials

Studying the relationship between the pharmacy and the clinical laboratory

continuation „Clinical Pharmacy 2. parts”

..

1.b) „Clinical pharmacy 2. parts”

Directives of the pharmacy

Studying pharmaceutical literature

Knowing reagents applied in diagnostics including preparation

Treatment of biological samples, basic clinical examinations, normal levels

Preparation and examination of emulsions and suspensions

Preparation and examination of emulsions and suspensions




Participating in works on different divisions of the pharmacy (labelling, packaging, etc.)





Preparation of complex infusions (cytostatic infusions, parenteral nutrition infusions)

Knowing and preparation of special magistral formulas, comparing with official formulas of FoNo VII. or Manuale

Pharmaceuticum




Participating in ordering of drugs on-line and off-line











Knowing other special tasks of the pharmacy (e.g.: measurement of drug concentration in plasma)


Knowing basic databases used in clinical pharmacy

Knowing the system of quality assurance

Knowing the quality assurance of the hospital emphasizing the regulations regarding the pharmacy

..

2. Public pharmacy operation

Public pharmacies’ measures concerning drug supply

In the pharmacy’s farming tasks truth participation

The acquisition of management, technical knowledge

Medicine farming: the procession of the medicine order

The preparation of medicine orders

Contacts, information, the examination of orders, complaints lasted with the medicine wholesalers

With the implements to be checked increased related knowledge and tasks

In the course of the waste product, the returns, a damage truth tasks

It is related to changes in price tasks


35

The closings: daily, weekly, snow end ill. OEP meanings

The knowledge of measures, bulletins

A drawer pharmacy’s, „kézigyógyszertár” concepts, knowledge, tasks

The knowledge of the officinal literature

The acquisition of the officinal computer program with a skill level

..

3.Pharmaceutical practice, receipt, preparate

The accomplishment of the medicine making processes turning up in the pharmacy with the management of a teaching chemist

The pharmacy’s inner cheque activity in the process of the medicine making

Unique praescriptions his cognition, his completion, their comparison the official one with praescriptions

Pharmacopoeia, FoNo

Laboration concept, the differences of processes, completions the unique one prescriptions his making, documentation

His Manual cognition, his application and prescription his editing

The nomenclature of the stocks, regular pharmacopoeia full Latin ill. his abridged name

Medicine cheque: the incoming medicines, stocks, basis artefacts, vegetal drugs, bandages, etc. His regular receipt

The the examination of stocks and his documentation arrived

The laboured the cheque of artefacts (pl. 70% Ethanolum, Sirup. simplex)

The aseptic working in the pharmacy, a principle, practice

Sterile, documentation, sterile apparatus cheque

The recognition of incompatibilities, correct completions, physical, chemistry, kolloidikai the reasons of incompatibilities and

technological solutions

Seminars


Knowledge acquired is evaluated based on reports made during pharmacy practice and the evaluation of the tutor/chief pharmacist.

Participants

Felkért előadó (FELKERTOKTATO)


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OPS-ZG2-T PROFESSIONAL PRACTICE BEFORE STATE EXAMINATION 2

Course director: DR. PÉTER KÁSA, senior research fellow

Institute of Pharmaceutical Technology and Biopharmacy [email protected]

16 credit ▪ midsemester grade ▪ Final/Rotational (year) subject ▪ spring semester ▪ recommended semester: 10



Topic

Aim of the first part of rigorous year is to expand the knowledge and approach of student with practice oriented pharmaceutics, knowing

the aspects of pharmaceutical care, economy and preparing medicines both in the public pharmacy and in clinical/hospital pharmacies.

This course is expanded with practice in clinical/hospital pharmacies in order to learn the tasks and connections of the pharmacy with

other wards of the hospital.

The 6 months have 6 thematics, one thematic 1-1 months time.

Proposal in the Hungarian pharmacy practice with Hungarian Student together.




The practice 4 months propose in the Hungarian pharmacy.

Mid-term exams




During the 6 months practice only 5 days are allowed to miss confirmed by a physician. More days of missing must be supplemented.

Reading material


Dévay: The Theory and Practice of Pharmaceutical Technology, e-book, http://gytsz.pte.hu/en/egyseg/oktatasianyagok/1620/

White coat, Protective shoes


- Notes

Final exam - test-book


European Pharmacopoeia

Pharmacopoeia Hungarica

Hungarian National Formulary: Formulae Normales VII (FoNo VII)

Compendium

Lectures

Practices

1. Clinical pharmacy

Knowing the structure of hospital/clinic

Studying the relationship between the pharmacy and other wards











Pharmaceutical economy, ordering medicines


http://gytsz.pte.hu/en/egyseg/oktatasianyagok/1620/


37










Directives of the pharmacy















Preparation of complex infusions (cytostatic infusions, parenteral nutrition infusions)

Knowing and preparation of special magistral formulas, comparing with official formulas of FoNo VII. or Manuale

Pharmaceuticum


















Knowing the system of quality assurance


..

2. Public pharmacy operation

Public pharmacies’ measures concerning drug supply

In the pharmacy’s farming tasks truth participation

The acquisition of management, technical knowledge

Medicine farming: the procession of the medicine order

The preparation of medicine orders,

Contacts, information, the examination of orders, complaints lasted with the medicine wholesalers

With the implements to be checked increased related knowledge and tasks

In the course of the waste product, the returns, a damage truth tasks

It is related to changes in price tasks

The closings: daily, weekly, snow end ill. OEP meanings

The knowledge of measures, bulletins


38

A drawer pharmacy’s, „kézigyógyszertár” concepts, knowledge, tasks

The knowledge of the officinal literature


...

3. Pharmaceutical practice, receipt, preparate

The accomplishment of the medicine making processes turning up in the pharmacy with the management of a teaching chemist

The pharmacy’s inner cheque activity in the process of the medicine making

Unique praescriptions his cognition, his completion, their comparison the official one with praescriptions

(Pharmacopoeia, FoNo)

Laboration concept, the differences of processes, completions the unique one prescription his making, documentation

His Manual cognition, his application and előirat his editing

The nomenclature of the stocks, regular pharmacopoeia full Latin ill. his abridged name

Medicine cheque: the incoming medicines, stocks, basis artefacts, vegetal drugs, bandages, etc. his regular receipt

The examination of stocks and his documentation arrived

The laboured the cheque of artefacts (pl. 70% Ethanolum, Sirup. simplex)

The aseptic working in the pharmacy, a principle, practice

Sterile, documentation, sterile apparatus cheque

The recognition of incompatibilities, correct completions, physical, chemistry, kolloid reasons of incompatibilities and

technological solutions

..

4. Medicine wholesale (expedition), officinal quality assurance

The pharmacy’s inner cheque activity in the processes of the medicine wholesale


The categories of storage, storage, his documentations, the cold chain chekd his process

The cognition of the medicines, replaceabilities, strength / cross marks

The prescription in the case of his regularity, formal deficiencies the tasks

The treatment of veterinary science prescriptions

The artefacts which can be received without the prescription (OTC) his concept, knowledge, dispatching

The groups of products which can be distributed in a pharmacy, his knowledge

The recognition of incompatibilities, on emphasized one the pharmacology incompatibilities, tasks, solution opportunities

Solutions according to Polipragmazia cognition, hygienic viewpoints - contact with doctors, patients

The expense of artefacts to be checked increased, his documentations

The significance of the retaxa and his practice

Correct communication towards the patients in a principle and the practice

The knowledge of the officinal quality assurance system

...

5. Medicine - pharmaceutical review

Officinal literature, technical books the knowledge of journals, his availability

Correct communication towards the hygienic specialists

Hygienic counsel towards different age groups (school, caretaker at home)

Pedigreed medicines, nutritions, bandages, therapeutic equipment, his knowledge

The artefacts which can be received without the prescription (OTC) his concept, knowledge, dispatching

The groups of products which can be distributed in a pharmacy, his knowledge

For the officinal employees medicine review from an actual artefact (recording, in the framework of inner professional

development)

The correct assessment of homoeopathic prescriptions, products, his conceptual and practical knowledge

..

6. Pharmacist nurture

The cognition of the legal regulation being attached to the chemist nurture

The levels of the chemist nurture, the conditions of his order

Pharmaceutical Nurture Committee characters, his tasks

Good Pharmacy Practice (GPP) the knowledge of his governing principles

Elementary level chemist medicine safety cheque made in the framework of nurture vocational governing principle applying his

knowledge and practical one

For the International Classification of the illnesses (in Hungarian BNO) his knowledge

BNO being found the most mostly the cognition of codes

The resuscitation of the pathologic and clinical knowledge of illnesses

Self-therapy the information of his concept, his practice, patients

Officinal literature, technical books the knowledge of journals, his availability


39

Seminars


Knowledge acquired is evaluated based on reports made during pharmacy practice and the evaluation of the tutor/chief pharmacist.

Participants

STUDY PROGRAM 2021/2022 Subjects of the 9-10. semesters ...

Documents

Transcript of STUDY PROGRAM 2021/2022 Subjects of the 9-10. semesters ...