STUDY PROGRAM 2015/2016 Subjects of the 9-10. semesters ...

University of Pécs Medical School

PHARMACY Major

STUDY PROGRAM 2015/2016

Subjects of the 9-10. semesters

(obligatory subjects and criterion requirements)

UP MS Pharmacy major – obligatory subjects of the 9-10. semester - Course descriptions – academic year of 2015/2016

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9th semester OPG-GS3 _______ Pharmacodynamics 3 __________________________________________________________________ 3 OPG-GSI _______ Pharmaceutical Informatics _____________________________________________________________ 7 OPG-KLF ______ Clinical Pharmacology _________________________________________________________________ 9 OPG-NOV ______ Herbal Medicine and Herbs in Nutrition __________________________________________________ 11 OPG-PMG ______ Problemsolving Pharmacy _____________________________________________________________ 14 OPG-TOX ______ Toxicology _________________________________________________________________________ 16 OPG-UI4 _______ Pharmaceutical Practice and Management 3 _______________________________________________ 18 OPO-KL2 _______ Clinical Studies 2 ____________________________________________________________________ 22 OPO-KLV ______ Clinical Laboratory Investigations _______________________________________________________ 25 OPS-SG3 _______ Professional Practice Before State Examination 1 ___________________________________________ 27

10th semester OPS-SG4 _______ Professional Practice Before State Examination 2 ___________________________________________ 30


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OPG-GS3 PHARMACODYNAMICS 3 Course director: DR. GÁBOR PETHŐ, professor Department of Pharmacology and Pharmacotherapy

4 credit ▪ final exam ▪ Pharmaceutical theoretical knowledge and practical skills module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 0 practices + 24 seminars = total of 48 hours Course headcount limitations (min.-max.): 5 – Prerequisites: OPG-GH2 completed + OPG-GK4 completed + OPG-GT4 completed

Topic

The aim of the course is to provide the students with pharmacological knowledge that is required for their future work in the pharmacy. Important topics are pharmacology of the endocrine system; chemotherapy of microbial diseases including antibacterial, antifungal drugs, antiviral antiprotozoal, antihelminthic agents, antiseptics and disinfectants; drugs used in chemotherapy of neoplastic diseases; immunosuppressants, immunomodulators, drug treatment of rheumatoid arthritis. Further topics are pharmacogenetics; effects of age, diet and diseases on drug action; drug interactions.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

There is no midterm test.

Making up for missed classes

There is no way to make up for missed lectures or seminars.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

Rang, Dale, Ritter, Moore: Pharmacology, 8th edition, Elsevier Churchill Livingstone, 2015 B. G. Katzung (ed.): Basic and Clinical Pharmacology, 12th edition, Lange Medical Books/McGraw-Hill, 2012

Lectures

1 Corticosteroids I Dr. Pethő Gábor 2 Corticosteroids II Dr. Pethő Gábor 3 Corticosteroids III Dr. Pethő Gábor 4 Oestrogens and anti-oestrogens Dr. Pethő Gábor 5 Progestins and anti-progestins Dr. Pethő Gábor 6 Postmenopausal hormone therapy. Hormonal contraceptives Dr. Pethő Gábor 7 Androgens, anabolic steroids and anti-androgens I Dr. Pethő Gábor 8 Androgens, anabolic steroids and anti-androgens II Dr. Pethő Gábor 9 Thyroid hormones, antithyroid drugs I Dr. Sághy Éva 10 Thyroid hormones, antithyroid drugs II Dr. Sághy Éva


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11 Hypothalamic and pituitary hormones I Dr. Pethő Gábor 12 Hypothalamic and pituitary hormones II Dr. Pethő Gábor 13 Hypothalamic and pituitary hormones III Dr. Pethő Gábor 14 Insulin, oral hypoglycaemic agents I Dr. Pethő Gábor 15 Insulin, oral hypoglycaemic agents II Dr. Pethő Gábor 16 Insulin, oral hypoglycaemic agents III. Glucagon Dr. Pethő Gábor 17 Parathyroid hormone, calcitonin, vitamin D and drug treatment of osteoporosis I Dr. Sághy Éva 18 Parathyroid hormone, calcitonin, vitamin D and drug treatment of osteoporosis I Dr. Sághy Éva 19 Drugs used in neoplastic diseases I Dr. Pethő Gábor 20 Drugs used in neoplastic diseases II Dr. Pethő Gábor 21 Drugs used in neoplastic diseases III Dr. Pethő Gábor 22 Drugs used in neoplastic diseases IV Dr. Pethő Gábor 23 Immunosuppressants and immunomodulators Sánticsné Dr. Pintér Erika 24 Drugs used to treat rheumatoid arthritis Sánticsné Dr. Pintér Erika

Practices

Seminars

1 Basic principles of antimicrobial chemotherapy 2 Sulphonamides and trimethoprim 3 Fluoroquinolones 4 Beta-lactam antibiotics I 5 Beta-lactam antibiotics II 6 Beta-lactam antibiotics III. Glycopeptide antibiotics 7 Aminoglycosides 8 Macrolide antibiotics 9 Tetracyclines, chloramphenicol 10 Linezolid, clindamycin, metronidazol 11 Antituberculotic drugs 12 Anti-leprosy drugs 13 Antifungal drugs I 14 Antifungal drugs II 15 Antiviral drugs I 16 Antiviral drugs II 17 Antiprotozoal drugs I 18 Antiprotozoal drugs II 19 Anthelminthic drugs I 20 Anthelminthic drugs II 21 Antiseptics and disinfectants I 22 Antiseptics and disinfectants II 23 Pharmacogenetics, pharmacogenomics 24 Effects of age, diet and disease on drug action. Drug interactions


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Exam topics/questions

1. Basic mechanisms of drug actions (examples of drug effects on receptors, ion channels, enzymes, carrier systems and effects mediated by physicochemical interactions)

2. Characterisation of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy 3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs 4. Mechanisms of drug antagonisms 5. Transport of drugs across membranes 6. Absorption of drugs, oral bioavailability and presystemic elimination 7. Plasma protein binding and tissue distribution of drugs 8. Biotransformation of drugs 9. Excretion of drugs 10. Pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability,

calculation of loading and maintenance doses 11. Drug development 12. Harmful effects of drugs and their mechanisms 13. Factors influencing drug effects: genetic constitution, age, diet, disease 14. Drug interactions 15. Cholinergic agonists and cholinesterase inhibitors 16. Muscarinic receptor antagonists 17. Neuromuscular blocking agents. Drugs acting on autonomic ganglia 18. Agents acting on the biosynthesis, storage, release and elimination of catecholamines 19. Adrenergic receptor agonists 20. Adrenergic receptor antagonists 21. Local anaesthetics 22. Calcium channel blockers 23. Drugs acting on the renin-angiotensin-aldosterone system 24. Diuretic drugs 25. Positive inotropic and other drugs used to treat congestive heart failure 26. Antianginal drugs. Drugs that increase regional blood flow 27. Antihypertensive drugs 28. Antiarrhythmic drugs 29. Antianxiety and hypnotic drugs 30. Alcohols: pharmacology, toxicology 31. Antipsychotic drugs 32. Antidepressants 33. Central nervous system stimulants. Nootropic drugs 34. Drug treatment of neurodegenerative disorders 35. General anaesthetics 36. Antiepileptic drugs 37. Opioid analgesic drugs: morphine and codeine 38. Opioid analgesic drugs: semisynthetic, synthetic opioids, opioid antagonists 39. Non-steroidal antiinflammatory drugs: aspirin, paracetamol 40. Non-steroidal antiinflammatory drugs: drugs other than aspirin or paracetamol 41. Adjuvant analgesics. Drugs used to treat gout. Centrally-acting muscle relaxants 42. Basic terms of drug abuse. Psychedelics, nicotine, cannabis, inhalants 43. Drugs used to treat hyperlipoproteinaemias 44. Drugs affecting haemostasis 45. Drugs affecting haematopoiesis 46. Histamine, H1 and H2 receptor antagonists 47. Serotonin, serotonin receptor agonists and antagonists 48. Pharmacology of eicosanoids. Drugs acting on the smooth muscle: smooth muscle relaxants, pharmacology of the uterine muscle 49. Drugs used in bronchial asthma 50. Drugs used in allergic rhinitis. Antitussive, expectorant and mucolytic agents 51. Drugs used in the treatment of peptic ulcer 52. Emetics, antiemetics and prokinetic drugs. Digestives, drugs used in cholelithiasis 53. Laxatives, antidiarrhoeal agents, drug treatment of inflammatory bowel diseases 54. Corticosteroids 55. Oestrogens, antioestrogens, progestins, antiprogestins


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56. Postmenopausal hormone therapy and hormonal contraceptives 57. Androgens, anabolic steroids, antiandrogens 58. Thyroid hormones, antithyroid drugs 59. Hypothalamic and pituitary hormones 60. Insulin and oral hypoglycaemic agents. Glucagon 61. Parathyroid hormone, calcitonin and vitamin D, drugs used to treat osteoporosis 62. Sulphonamides and trimethoprim. Fluoroquinolones 63. Beta-lactam antibiotics 64. Glycopeptide antibiotics, aminoglycosides, macrolide antibiotics 65. Tetracyclines, chloramphenicol, linezolid, clindamycin, metronidazol 66. Antituberculotic drugs. Anti-leprosy drugs 67. Antifungal drugs 68. Antiviral drugs 69. Antiprotozoal drugs 70. Anthelminthic drugs 71. Antiseptics and disinfectants 72. Drugs used in the chemotherapy of neoplastic diseases: alkylating agents, antimetabolites 73. Drugs used in the chemotherapy of neoplastic diseases: alkaloids, antibiotics, hormonal agents, biological therapy 74. Immunosuppressants and immunomodulators. Drug used to treat rheumatoid arthritis In addition to the exam topics, an important part of the exam is questions that aim at assessing the general knowledge of the student.

Participants

Dr. Pethő Gábor (PEGGAAO.PTE), Dr. Sághy Éva (SAEPABO.PTE), Dr. Sándor Zsolt István (SAZFABO.PTE)


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OPG-GSI PHARMACEUTICAL INFORMATICS Course director: DR. LAJOS BOTZ, professor Medical Faculty (Medical School)

2 credit ▪ midsemester grade ▪ Pharmaceutical theoretical knowledge and practical skills module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 12 lectures + 12 practices + 0 seminars = total of 24 hours Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GI3 completed

Topic

Students will become familiar with pharmaceutical databases, IT communication systems and clinical drug management software applications. Pharmaceutical IT methods such as telemedicine, or Internet pharmacies will be also covered in lectures. Lectures will give students insight into ethical and legal aspects of information sources, and their critical evaluation. The aim of the lectures is to consolidate the pharmaceutical IT skills of students. Students will be equipped with up-to-date pharmaceutical IT skills: use of databases and Internet information sources. During the semester the students will become familiar with the basics of personal computer and network systems is general and with the specifications of pharmaceutical informatics, such as the development and stages of pharmacy informatics, principles of pharmacy software. Also the different software types and drug dispensing rules used in pharmacies are introduced in this semester. The basic knowledge of drug interactions and the available techniques and databases for screening interactions in everyday practice is also an emphasized topic. After acquiring the principles of informatics and pharmaceutical informatics the students will be able to synthesize the elements and understand the functions of pharmacy information management systems. Even the possibilities and threats of online drug marketing and the capability of finding relevant and authentic pharmaceutical information on the web is the objective of this course.


Acceptance of term/semester (provisions of casting to examination): A. Regular attendance of classes (maximum 25 % of absence is accepted), B. Assignments given in class should be carried out during term-time and, C. The mid-term test should be passed (minimum 60%) D. The end-of-the-term test should be passed (minimum 60% - grade 2).

Mid-term exams


Compensation is possible following personal discussion.

Reading material



List of study aids to acquire curriculum (books, notes, other) and all presentations can be downloaded from CooSpace.

- Notes


Ed. R. Fisher: Information Technology for Pharmacists, Pharmaceutical Press Brent I. Fox, Margaret R. Thrower, Bill G. Felkey: Building Core Competencies in Pharmacy Informatics, American Pharmacists Association, 2010

Lectures

1 Drug interactions 1. Interpretation of drug interactions, professional background Dr. Végh Anna 2 Drug interactions 2. Ways of screening drug interactions, adequate evaluation Dr. Végh Anna 3 Drug interactions 3 Dr. Végh Anna 4 Drug interactions 4 Dr. Végh Anna 5 Practical use of Evidence-based Practice 1 Dr. Takács Gábor 6 Practical use of Evidence-based Practice: Answering therapeutic questions 1 Dr. Takács Gábor 7 Acquiring information and databases Dr. Fittler András Tamás 8 Development and basics of professional pharmaceutical informatics Dr. Fittler András Tamás


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9 Drug marketing on the web. Finding pharmaceutical information Dr. Fittler András Tamás 10 Personal computer and network systems fundamentals. Pharmacy information management systems Dr. Fittler András Tamás 11 Development and stages of pharmacy informatics. Principles of pharmacy softwares Dr. Fittler András Tamás 12 Different software types used in pharmacies, drug dispensing rules Dr. Fittler András Tamás

Practices

1 Retail pharmacy software: features and structure of professional pharmaceutical systems 2 Pharmaceutical software for the follow-up of work procedures (compounding, drug manufacturing) 3 Pharmacy software: for the follow-up of work procedures (dispensing) 1 4 Pharmacy software: for the follow-up of work procedures (dispensing) 2 5 Application of professional pharmaceutical software interfaces for the improvement of medication of patients (filtering of

endangered patient groups and drug interactions) 6 Pharmacy software: for the follow-up of work procedures: (management, accounting of prescriptions) 7 Developing appropriate professional information 8 Informatics fundamentals of integrated health care providers 9 Interfaces of pharmacy software and trends in innovation 10 Prescribing medications 1. Interactive lecture 11 Prescribing medications 2. Interactive lecture 12 Prescribing medications 3. Interactive lecture

Seminars


Based on the topics of the lectures and seminars.

Participants

Dr. Botz Lajos (BOLFAAP.PTE), Dr. Fittler András Tamás (FIAQAAK.PTE), Dr. Végh Anna (VEAOABO.PTE), Dr. Vida Róbert György (VIRNAAO.PTE)


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OPG-KLF CLINICAL PHARMACOLOGY Course director: DR. ERIKA PINTÉR, professor Department of Pharmacology and Pharmacotherapy

1 credit ▪ semester exam ▪ Pharmaceutical theoretical knowledge and practical skills module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 15 lectures + 0 practices + 0 seminars = total of 15 hours Course headcount limitations (min.-max.): 2 – 40 Prerequisites: OPO-KL2 parallel + OPG-HT3 parallel

Topic

In the frame of this one semester subject (15 lectures) students get acquainted with the next clinical pharmacological terms and sections: history of the drug research, rational drug design, preclinical development, safety pharmacology, clinical studies (Phase I-II-III-IV), Good Clinical Practice. Documentation of clinical trials. Practical aspects of clinical studies. Evidence-based medicine.



Mid-term exams


None

Reading material



Lectures made available on Coospace.

- Notes


Lectures

1 History of drugs Sánticsné Dr. Pintér Erika 2 History of drugs Sánticsné Dr. Pintér Erika 3 Drug discovery and development Dr. Bölcskei Kata 4 Drug discovery and development Dr. Bölcskei Kata 5 Drug discovery and development Dr. Bölcskei Kata 6 Preclinical testing Dr. Bölcskei Kata 7 Preclinical testing Dr. Bölcskei Kata 8 Preclinical testing Dr. Bölcskei Kata 9 Design and conduct of clinical trials Dr. Bölcskei Kata 10 Design and conduct of clinical trials Dr. Bölcskei Kata 11 Design and conduct of clinical trials Dr. Bölcskei Kata 12 GMP, GLP, GCP Dr. Bölcskei Kata 13 GMP, GLP, GCP Dr. Bölcskei Kata 14 Documentation of the clinical studies Dr. Bölcskei Kata 15 Documentation of the clinical studies Dr. Bölcskei Kata


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Practices

Seminars


Written exam based on the lectures

Participants


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OPG-NOV HERBAL MEDICINE AND HERBS IN NUTRITION Course director: DR. TAMÁS ANTAL KŐSZEGI, associate professor Department of Pharmacognosy

2 credit ▪ semester exam ▪ Pharmaceutical theoretical knowledge and practical skills module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours Course headcount limitations (min.-max.): 1 – Prerequisites: OPG-FG2 completed + OPG-GH2 completed

Topic

Aims of the subject: To give an overview for the students on the biological effects of generally used herbs, drugs and herbal nutrients on the human body (beneficial and hazardous as well). To demonstrate the mode of action, indications and applications of herbal drugs in the most important disease groups by showing practical examples and case reports. To make emphasis on the interactions of herbal constituents with allopathic drugs used in modern medicine. The curriculum helps proper orientation among today’s frequent misbelieves and myths by the methods of evidence based medicine.



Mid-term exams

A multiple choice mid-term is due in October


An absence rate of less than 25% is acceptable, no medical or other certificate is necessary. Management of catch up for absences is possible by personal consultation with the tutor.

Reading material



All lectures are accessible at Coospace

- Notes


Aronson J.K. (ed.): Meyler’s Side Effects of Herbal Medicines, Elsevier, Amsterdam-Oxford-Tokyo, 2009 Barnes J., Anderson L.A., Phillipson J.D.: Herbal Medicines, 2nd edition, Pharmaceutical Press, London-Chicago, 2002 ESCOP Monographs, The Scientific Foundation for Herbal Medicinal Products, 2nd edition, Thieme, Exeter; Stuttgart; New York, 2003 European Medicines Agency guidelines; www.ema.europa.eu

Lectures

1 Major biological effects of herbs used in the human diet Dr. Kőszegi Tamás Antal 2 Characteristics of an optimal nutritional regime for maintenance of health in regard of herbal constituents of different diets Dr. Kőszegi Tamás Antal 3 Biochemical testing methods for the assessment of biological effects of herbal extracts in cellular model systems Dr. Kőszegi Tamás Antal 4 Effects of antioxidants and other cytoprotective molecules of plant origin on cell energetics and free radical levels Dr. Kőszegi Tamás Antal 5 Application of plant extracts and monitoring procedures of their action at the body level Dr. Kőszegi Tamás Antal 6 Herbal formulations with immuno-modulant activity; case discussion Dr. Kőszegi Tamás Antal 7 Application of herbal medicine based on ethnopharmacobotany and evidence based medicine Dr. Papp Nóra 8 Application of herbal medicine based on ethnopharmacobotany and evidence based medicine Dr. Papp Nóra 9 Authentic judgement of plant based dietary supplements using the conception of evidence based medicine Dr. Kőszegi Tamás Antal 10 The problematic of plant based dietary supplements: evidences, myths and disbelieves Dr. Kőszegi Tamás Antal


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11 Role of herbal medicine in common cold (diseases of the upper respiratory tract: flue like symptoms); application of methods based on traditions and on scientific evidences

Dr. Farkas Ágnes 12 Herbal remedies in lowering blood cholesterol levels; plants with antidiabetic activity Dr. Farkas Ágnes 13 Major aspects of prevention and therapy of cardiovascular diseases (nutrition and medicinal herbs) Dr. Kőszegi Tamás Antal 14 Cardiovascular diseases; case discussion Dr. Kőszegi Tamás Antal 15 Complementary therapy of chronic bone and joint diseases Dr. Kőszegi Tamás Antal 16 Rheumatoid arthritis; case discussion Dr. Kőszegi Tamás Antal 17 Medicinal plant drug nutrient interactions Dr. Horváth Györgyi 18 Medicinal plant drug nutrient interactions Dr. Horváth Györgyi 19 Nutritional and herbal medicine approaches in malignant diseases Dr. Kőszegi Tamás Antal 20 Complementary therapy of malignant diseases; case discussion Dr. Kőszegi Tamás Antal 21 Restoration of the various balances in the gastrointestinal tract by phytotherapy and microbiological therapy Dr. Kőszegi Tamás Antal 22 Useful complementary methods in the diseases of the gastrointestinal tract; case discussion Dr. Kőszegi Tamás Antal 23 Body care with roborant; vitamin and antioxidant containing phytotherapeutic agents and lotions Dr. Kőszegi Tamás Antal 24 Body care with roborant; vitamin and antioxidant containing phytotherapeutic agents and lotions; critical evaluation Dr. Kőszegi Tamás Antal

Practices

Seminars


1. Why plants used in human nutrition may be considered to function as medicinal herbs? Give examples. 2. What types of cytoprotective factors can be found in fruits and vegetables? 3. What are the most important constituents of plant origin in the human diet for maintenance of health? 4. Give a few examples for in vitro assessment of biological effects of plant extracts in cellular models. 5. How antioxidant capacity can be measured using in vitro cellular models? How cell energetics can be characterized by laboratory

approaches? 6. Give a few clinical laboratory tests for estimation of biological effects of plant extracts at the body level (e.g. antioxidant,

antiinflammatory, antidiabetic, influencing lipid metabolism, etc.). 7. What does immune modulation mean? List a few practical examples with the mention of active ingredients. 8. Plants, herbal drugs and traditional names of them. Different examples for confusing and mismatching herbal names in phytotherapy. 9. Evaluation of traditional medicine in view of evidence based medicine (give examples). 10. What are the major rules in proper application of dietary supplements? 11. What are the contraindications in application of dietary supplements (give examples)? 12. List the most important medicinal herbs applied in the complementary therapy of common cold and name their active ingredients. 13. Herbal drugs influencing lipid metabolism and their proper application. 14. Safe application of medicinal herbs in diabetes mellitus (active agents, complex herbal formulations). 15. Complementary therapies with indications and contraindications in cardiovascular diseases (give examples). 16. Mineral supplementation in metabolic bone diseases (including microbiological therapy). 17. Different immune modulation therapies in rheumatoid arthritis. 18. Give some examples in detail on modern drug-herbal medicine interactions with serious outcome (with reference of active

ingredients). 19. Give some examples of important food-drug interactions with reference of active ingredients. 20. List those complementary therapeutically acceptable modalities which can be interpreted by the principles of evidence based

medicine. 21. Name those complementary therapies or processes that are contraindicated in malignant diseases (active agents, ingredients). 22. Explain why restoration of function, bacterial micro flora and permeability of the gastrointestinal tract is of vital importance?


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23. Major indication of phytotherapeutical treatments in certain diseases of the gastrointestinal tract (name the active agents as well). 24. Explain the proper administration routes of vitamins, antioxidants and roborants and their indications. 25. Give description on professional compliance for formulations of external use and of cosmetics containing natural ingredients.

Participants


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OPG-PMG PROBLEMSOLVING PHARMACY Course director: DR. ERIKA PINTÉR, professor Department of Pharmacology and Pharmacotherapy

2 credit ▪ midsemester grade ▪ Pharmaceutical theoretical knowledge and practical skills module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 21 lectures + 0 practices + 0 seminars = total of 21 hours Course headcount limitations (min.-max.): 1 – 40 Prerequisites: OPG-GH2 completed + OPG-HT3 parallel

Topic

Training for the practical aspects of the pharmacist praxis. Discussions of the case reports.



Mid-term exams


None

Reading material



Lecture notes made available on Intranet

- Notes


Lectures

1 Drug therapy problems of cardiovascular diseases, (palpitations, chest pain, edema, dizziness, weakness, headache) Sánticsné Dr. Pintér Erika 2 Drug therapy problems of cardiovascular diseases, (palpitations, chest pain, edema, dizziness, weakness, headache) Sánticsné Dr. Pintér Erika 3 Tasks of the pharmacist in the treatment of diabetes Sánticsné Dr. Pintér Erika 4 Drug treatment of gastrointestinal disorders (anorexia, vomiting, diarrhea, constipation, abdominal pain, bloody stools) Dr. Bölcskei Kata 5 Drug treatment of gastrointestinal disorders (anorexia, vomiting, diarrhea, constipation, abdominal pain, bloody stools) Dr. Bölcskei Kata 6 Pharmacotherapeutic problems of respiratory diseases (cough, runny nose, shortness of breath, wheezing, chest pain) Dr. Bölcskei Kata 7 Pharmaceutical problems of coagulation disorders (warfarin, heparin therapy, interactions, bleeding) Dr. Bölcskei Kata 8 Neurological diseases pharmacotherapy problems: (dizziness, headache, tinnitus, loss of consciousness, pain, paralysis) Dr. Bölcskei Kata 9 Neurological diseases pharmacotherapy problems: (dizziness, headache, tinnitus, loss of consciousness, pain, paralysis) Dr. Bölcskei Kata 10 The specific pharmacological problems of pediatrics 1 Sánticsné Dr. Pintér Erika 11 The specific pharmacological problems of pediatrics 2 Sánticsné Dr. Pintér Erika 12 Inflammatory, allergic diseases Sánticsné Dr. Pintér Erika 13 Anxiety, depression, drug abuse Sánticsné Dr. Pintér Erika 14 Support of the antidepressant therapy by the pharmacist Sánticsné Dr. Pintér Erika


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15 Pharmacological problems of pain management 1 Dr. Bölcskei Kata 16 Pharmacological problems of pain management 2 Dr. Bölcskei Kata 17 Problem solving in the current scope of antimicrobial therapy 1 Dr. Botz Lajos 18 Problem solving in the current scope of antimicrobial therapy 2 Dr. Botz Lajos 19 Medication problems during pregnancy and lactation Dr. Fittler András Tamás 20 Contraception, therapeutic use of drugs for treatment of genitals Dr. Fittler András Tamás 21 Drugs used for treatment of sensory organs Dr. Fittler András Tamás

Practices

Seminars


Written exam based on the lectures. Lecture notes made available on Intranet Drug therapy problems of cardiovascular diseases, (palpitations, chest pain, edema, dizziness, weakness, headache) Medical treatment of gastrointestinal disorders (anorexia, vomiting, diarrhea, constipation, abdominal pain, bloody stools) Pharmacotherapeutic problems of respiratory disease (cough, runny nose, shortness of breath, wheezing, chest pain) Pharmaceutical problems affecting coagulation disorders (warfarin, heparin therapy, interactions, bleeding) Neurological diseases pharmacotherapy problems: (dizziness, headache, tinnitus, loss of consciousness, pain, paralysis) The specific pharmacological problems of pediatrics Inflammatory, allergic diseases Anxiety, depression, drug abuse Problems of pharmacological pain management Problem solving in the current scope of antimicrobial therapy Applications of dermatological preparations (rash, itching, peeling, dermatitis, wound care, dry skin) Arising medication problems during pregnancy and lactation Contraception, therapeutic use of drugs for treatment of genitals. Drugs used for treatment of sensory organs.

Participants

Dr. Botz Lajos (BOLFAAP.PTE), Dr. Bölcskei Kata (BOKFABO.PTE), Dr. Fittler András Tamás (FIAQAAK.PTE), Sánticsné Dr. Pintér Erika (PIEMAAO.PTE)


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OPG-TOX TOXICOLOGY Course director: DR. BALÁZS FERENC NÉMETI, associate professor Department of Pharmacology and Pharmacotherapy

2 credit ▪ semester exam ▪ Pharmaceutical theoretical knowledge and practical skills module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours Course headcount limitations (min.-max.): 2 – 60 Prerequisites: OGG-HT3 parallel + OPG-GK4 completed

Topic

Toxicology as a subject deals with the adverse health effects, including developmental adverse effects and carcinogenic effects, of drugs and other xenobiotics (e.g., pesticides, solvents, metal compounds, toxic gases, chemical warfare agents, mushroom- and plant-derived toxins) caused by overdose or excessive exposure. It describes the manifestations of the harmful effects, the mechanisms involved in the adverse outcome, the major factors influencing the development of toxic injury, the diagnostics of the adverse health effects, as well as their prevention and treatment. The principles and practice of safety evaluation of drugs (toxicity testing) and risk assessment of chemicals are also discussed.


Students are requested to take two multiple choice tests during the semester, and a final test at the end of the semester in the examination period. Their grades will be calculated from their performance (expressed as %) on these three tests. They can acquire 15-15% from the two tests during the instruction period and 70% from the final test. The cumulative score of the three tests should be at least 60% for the passing grade. The student who fails to take one or both tests during the instruction period can collect only 85 and 70%, respectively.

Mid-term exams

There are two test during the instruction period. Students can acquire 15-15% of the final result on these occasions. To make up for missed tests, students are required to present appropriate reason of missing and discuss the possibilities with the teacher.


Students missing a lecture can download the teaching material from the website of Department of Pharmacology and Pharmacotherapy. Alternatively, they can use the notes of fellow students who attended the lecture, or may consult with the teacher giving the lecture.

Reading material



Teaching materials available on the CooSpace.

- Notes


Casarett & Doull’s Toxicology, 8th edition, McGraw-Hill, 2013. The toxicology chapters of Pharmacology textbooks, e.g., Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th edition, 2011: Drug Toxicity and Poisoning; Environmental Toxicology; Timbrell, J.A.: Principles of Biochemical Toxicology, 4th edition, Taylor & Francis, Inc., London, 2008.

Lectures

1 The scope of toxicology. Human intoxications - Occurrence and classification. Causes of poisoning-related death. Dr. Gregus Zoltán 2 Management of the poisoned patients I. (emergency care, diagnostic procedures) Dr. Gregus Zoltán 3 Management of the poisoned patients II. (decontamination, antidotes) Dr. Gregus Zoltán 4 Management of the poisoned patients III. (enhancement of the elimination of toxicants, supportive treatment) Dr. Gregus Zoltán 5 Drug intoxications I Dr. Poór Miklós 6 Drug intoxications II Dr. Gregus Zoltán 7 Drug intoxications III Dr. Gregus Zoltán


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8 Intoxication with metals I. Mechanisms of metal toxicity. Protective mechanisms. Metal chelators. Dr. Németi Balázs Ferenc 9 Intoxication with metals II. Lead, mercury, cadmium. Dr. Németi Balázs Ferenc 10 Intoxication with metals III. Arsenic, chromium, cobalt, nickel, manganese. Dr. Németi Balázs Ferenc 11 Intoxication with pesticides I. General properties. Insecticides: halogenated hydrocarbons. Dr. Poór Miklós 12 Intoxication with pesticides II. Insecticides: Organophosphates and carbamates. Herbicides. Dr. Poór Miklós 13 Intoxication with pesticides III. Fungicides. Rodenticides. Fumigants. Dr. Gregus Zoltán 14 Intoxication with solvents I. Benzol, aliphatic hydrocarbons, carbon disulfide. Dr. Németi Balázs Ferenc 15 Intoxication with solvents II. Alcohols, glycols, halogenated hydrocarbons. Dr. Németi Balázs Ferenc 16 Toxic gases (CO, HCN and cyanogenic compounds, H2S). Dr. Gregus Zoltán 17 Hemolytic chemicals, methaemoglobin-forming chemicals. Dr. Gregus Zoltán 18 Chemical warfare agents I Dr. Németi Balázs Ferenc 19 Chemical warfare agents II. Chemical teratogenesis I Dr. Németi Balázs Ferenc 20 Chemical teratogenesis II Dr. Németi Balázs Ferenc 21 Chemical carcinogenesis I Dr. Gregus Zoltán 22 Chemical carcinogenesis II Dr. Gregus Zoltán 23 Toxicity testing and risk assessment - Principles and practices I Dr. Gregus Zoltán 24 Toxicity testing and risk assessment - Principles and practices II Dr. Gregus Zoltán

Practices

Seminars


All tests will consist of 50-70 multiple choice type questions and a few assay type questions, which are covered by the teaching materials attainable on the CooSpace and/or the oral lectures.

Participants


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OPG-UI4 PHARMACEUTICAL PRACTICE AND MANAGEMENT 3 Course director: DR. LAJOS BOTZ, professor Dept. of Pharmaceutics and University Pharmacy

5 credit ▪ final exam ▪ Pharmaceutical theoretical knowledge and practical skills module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 24 practices + 12 seminars = total of 60 hours Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GI3 completed + OPG-GH2 completed + OPG-GT4 completed

Topic

The lectures of the semester will further outline the pharmaceutical supply system, specific pharmacy practice knowledge in community and clinical professional pharmaceutical practice and care. Students will acquire skills in evaluating and interpreting reliable pharmaceutical information by getting familiar with the concepts of evidence based medicine and pharmacy informatics. In this semester also interactive discussions will cover essential topics regarding self-medication, patient counselling and over the counter products used in minor diseases. Detailed discussion of pharmacy practice will cover personal and objective criteria of pharmacies, prescribing and dispensing regulations, controlled drugs, ordering and stockpiling drugs. Ensuring medication safety in community and hospital pharmacy setting is a key element of modern pharmaceutical practice, thus the lectures focus on relevant issues. Students will discuss elements of ethical behavior and pharmacy ethics in practice. During the semester the students will become familiar with the basics of personal computer and network systems is general and with the specifications of pharmaceutical informatics, such as the development and stages of pharmacy informatics, principles of pharmacy software. Also the different software types and drug dispensing rules used in pharmacies are introduced in this semester. The basic knowledge of drug interactions and the available techniques and databases for screening interactions in everyday practice is also an emphasized topic. After acquiring the principles of informatics and pharmaceutical informatics the students will be able to synthesize the elements and understand the functions of pharmacy information management systems. Even the possibilities and threats of online drug marketing and the capability of finding relevant and authentic pharmaceutical information on the web is the objective of this course. Aims of lectures in pharmaceutical studies: The aims of the lectures in pharmaceutical studies are to broaden the pharmaceutical practice and management skills of students, and to generate interest in pharmacy as a profession. Main aim of these studies is to solidify pharmacy practice and related economic, clinical, pharmaceutical care, information technology, ethics knowledge in order to understand pharmacoeconomics, drug allocation, pharmaceutical management, health economics, evidence based medicine, clinical pharmacy services and general pharmaceutics. Further goal is to help students to gain insight into practical pharmaceutical work and into other professional knowledge. The interactive group work during the seminars will develop analytical, problem solving and creative thinking skills. Topics discussed during the lectures, but not included in the notes/books will also be included in the exams. Students can access the slides of the lectures and further reading material on a designated web based interface (CooSpace).


Acceptance of term/semester (provisions of casting to examination): A. Regular attendance of classes (maximum 25 % of absence is accepted), B. Assignments given in class should be carried out during term-time and, C. The mid-term test should be passed (minimum 60%) D. The end-of-the-term test should be passed (minimum 60% - grade 2).

Mid-term exams


Compensation is possible following personal discussion.

Reading material



List of study aids to acquire curriculum (books, notes, other) and all presentations can be downloaded from CooSpace.

- Notes


C. Bond (ed.): Evidence-based Pharmacy, Pharmaceutical Press, London, 2002. A. J. Winfield, R. M. E. Richards (eds.): Pharmaceutical Practice, Churchill Livingstone C. H. Knowlton, R. P. Penna (eds.): Pharmaceutical Care, ASHSP M. Stephens (ed.): Hospital Pharmacy, Pharmaceutical Press, London, 2006. Rosemary R. Berardi, Stefanie P. Ferreri et al.: Handbook of Nonpresciption Drugs, 17th edition, American Pharmacists Association, 2012. Walker, Roger: Clinical Pharmacy and Therapeutics, 2011.


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Edzard Ernst, Simon Singh: Trick or Treatment, W. W. Norton & Company, 2008. Section IV: Nutrition and Nutritional Supplementation, Section XI: Complementary and Alternative Medicine. Edzard Ernst, Simon Singh: Trick or Treatment? Alternative Medicine on Trial Brent I. Fox, Margaret R. Thrower, Bill G. Felkey: Building Core Competencies in Pharmacy Informatics, American Pharmacists Association, 2010

Lectures

1 Hospital pharmacy services Dr. Takács Gábor 2 Clinical pharmacy services 1 Dr. Takács Gábor 3 Clinical pharmacy services 2 Dr. Vida Róbert György 4 Drugs in pregnancy and lactation Dr. Takács Gábor 5 Pharmaceutical Care: Geriatrics Dr. Fittler András Tamás 6 Pharmaceutical Care: Neonates and paediatrics Dr. Takács Gábor 7 Antidotes for toxicological emergencies Dr. Vida Róbert György 8 Oncology pharmacy Dr. Takács Gábor 9 Patient safety in clinical practice Dr. Fittler András Tamás 10 Volume therapy Dr. Takács Gábor 11 Pharmaceutical care in infectology Dr. Takács Gábor 12 Assuring medication safety in community pharmacy practice Dr. Fittler András Tamás 13 Controlled drugs - prescribing and dispensing regulations, international treaties Dr. Vida Róbert György 14 Monitoring medication safety Dr. Fittler András Tamás 15 Ordering, procurement, stockpiling and storing Dr. Vida Róbert György 16 Personal and objective criteria for pharmacies Dr. Fittler András Tamás 17 Detailed introduction to the dispensing practice Dr. Fittler András Tamás 18 Evaluating Clinical Trials from the aspect of EBM Dr. Takács Gábor 19 Fundamentals of EBM and Clinical Epidemiology 1 Dr. Takács Gábor 20 Evidence-based Practice. Most important internet databases Dr. Takács Gábor 21 How to formulate a question, searching strategy, evaluate methods, evaluate results, conclusions Dr. Fittler András Tamás 22 Principles of critical appraisal Dr. Fittler András Tamás 23 Interpreting results Dr. Fittler András Tamás 24 Test Dr. Botz Lajos


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Practices

1 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 1 2 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 2 3 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 3 4 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 4 5 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 5 6 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 6 7 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 7 8 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 8 9 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 9 10 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 10 11 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 11 12 Hospital and Clinical Pharmacy and Pharmaceutical Care of major diseases 12 13 Drug interactions 1 14 Drug interactions 2 15 Drug interactions 3 16 Drug interactions 4 17 Practical use of Evidence-based Practice 1 18 Practical use of Evidence-based Practice: Answering therapeutic questions 1 19 Pharmaceutical Ethics 1 20 Pharmaceutical Ethics 2 21 Personal computer and network systems fundamentals 22 Pharmacy information management systems 23 Drug marketing on the web. Finding pharmaceutical information 24 Development and stages of pharmacy informatics. Principles of pharmacy software. Different software types used in pharmacies,

drug dispensing rules

Seminars

1 Seborrheic dermatitis, psoriasis 2 Allergy and contact dermatitis 3 Vaginal and vulvovaginal disorders 4 Fungal skin infections, Athlete’s foot 5 Headache and migraine 6 Disorders related to colds 7 Cough and expectorants 8 Fever 9 Dyspepsia, heartburn and intestinal gas 10 Diarrhoea and constipation 11 Practical use of Evidence-based Practice: Answering therapeutic questions 2. 12 Practical use of Evidence-based Practice 2.


Final exam topics for PHARMACEUTICAL PRACTICE AND MANAGEMENT (Basic principles of pharmacy and Pharmaceutical practice and management 1, 2 & 3) Three exam topics shall be elaborated and presented during the final exam. Supplementary definitions and questions (which will not be highlighted during the exam) below the listed exam titles aim to specify the required knowledge for each topic. Certain contents of the discussed topics may be overlapping, while other exam topics require the association of professional pharmaceutical knowledge introduced during different lectures/semesters. 1. History of Pharmacy and Medicine. Pharmacy as a profession. 2. Development and role of Pharmacopoeias and formularies in pharmacy. 3. Product categories in community pharmacies. 4. Regulation and organization of Hungarian health system. 5. The drug supply chain, stakeholders of the drug supply system. 6. Personal and objective criteria for community, branch and single-handed pharmacies in Hungary. 7. Regulation of the prescribing and dispensing of medicines in Hungary. 8. Regulation regarding controlled drugs in Hungary. International drug control treaties.


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9. International and Hungarian health and pharmaceutical organizations. 10. Fundamentals of economics for pharmacists. Characteristics of market of healthcare and pharmaceuticals. 11. Health Economics and Pharmacoeconomics 1: Aims, methodology and the main methods. 12. Health Economics and Pharmacoeconomics 2: The concept, importance and measurement of the quality of life. 13. Drug utilization. Drug classification systems. 14. Rational and transparent drug selection. SOJA method. Decision Analysis. 15. Pricing and life cycle of drugs. 16. Health expenditures, drug/healthcare costs, cost-control techniques. 17. Development and types of social and health insurance systems. Characteristics of the Hungarian social and health insurance system. 18. Basics and practice of Marketing. 19. Drug Research and Development 1: Pre-clinical phase. 20. Drug Research and Development 2: Clinical trials. 21. Drug Research and Development 3: Phases in clinical trials. 22. Drug authorization process 1: Patent protection. 23. Drug authorization processes 2: Abridged authorization. Off-label use of drugs. Orphan drugs. 24. Drug authorization processes 3: Equivalencies of drugs. Substitution. 25. Placebo effect: the role of placebo in clinical trials and therapy. 26. Patients’ Rights. 27. Medication errors. 28. Adverse drug reactions. 29. Drug interactions. 30. Philosophy and development of evidence based medicine and pharmacy. 31. Hierarchy of medical information and clinical evidence clinical study designs. 32. The practical steps of evidence based practice. 33. Interpreting the results of evidence based practice: Outcome measures. 34. Hospital and clinical pharmacy 1: Life stages (pediatrics, geriatrics, gravidity and breast feeding). 35. Hospital and clinical pharmacy 2: Infectology and antibiotic stewardship. 36. Hospital and clinical pharmacy 3: Nutrition therapy. Fluid therapy. 37. Hospital and clinical pharmacy 4: The development and services of hospital and clinical pharmacy. 38. Hospital and clinical pharmacy 5: Oncology pharmacy. 39. The development, basics and techniques of pharmaceutical care. 40. Pharmaceutical care of respiratory diseases: allergic rhinitis, asthma bronchiale, COPD. 41. Pharmaceutical care of cardiometabolic syndrome 42. Self-Care and Nonprescription Pharmacotherapy 1: Patient assessment and consultation. 43. Self-Care and Nonprescription Pharmacotherapy 2: Dry skin, atopic dermatitis, acne, contact dermatitis and allergy. 44. Self-Care and Nonprescription Pharmacotherapy 3: Dyspepsia, heartburn and intestinal gas, diarrhea and constipation. 45. Self-Care and Nonprescription Pharmacotherapy 4: Fungal skin infections, vaginal and vulvovaginal disorders. 46. Self-Care and Nonprescription Pharmacotherapy 5: Headache, fever, cough and disorders related to colds. 47. Self-Care and Nonprescription Pharmacotherapy 6: Oral disorders, nutritional supplementation. 48. Good Communication in Pharmacy Practice. Written, electronic communication in Health care and holding oral presentations. 49. Medication adherence - Helping patients manage therapeutic regimens. 50. Pharmaceutical informatics.

Participants

Dr. Botz Lajos (BOLFAAP.PTE), Dr. Fittler András Tamás (FIAQAAK.PTE), Dr. Takács Gábor (TAGSAAP.PTE), Dr. Végh Anna (VEAOABO.PTE), Dr. Vida Róbert György (VIRNAAO.PTE)


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OPO-KL2 CLINICAL STUDIES 2 Course director: DR. ERIKA PINTÉR, professor Department of Pharmacognosy

5 credit ▪ semester exam ▪ Pharmaceutical Biology and Medical Knowledge module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 60 lectures + 0 practices + 0 seminars = total of 60 hours Course headcount limitations (min.-max.): 2 – Prerequisites: OPO-KL1 completed

Topic

The task of the subject is the transmission of the most fundamental knowledge of the clinical studies for the pharmacy students. The curriculum covers the most important diseases focusing on their pharmacotherapy. The task of this subject to promote the accurate knowledge pharmacotherapy in the clinical practise.



Mid-term exams


None

Reading material



Lecture notes

- Notes


Lectures

1 Gestation time, pregnancy diagnosis, growth of the uterus during pregnancy. Uncomplicated spontaneous labor. Disorders of pregnancy: hyperemesis gravidarum, abortion.

Dr. Kovács Kálmán András 2 Ultrasound examinations during pregnancy. Procedures for assessment of the status of the fetus in utero. Location of the fetus in

utero and its diagnosis. Dr. Kovács Kálmán András 3 Laying, holding, rotational and integration abnormalities. Natal complications: breech, vacuum forceps, sectio Caesara, preterm

birth, preeclampsia, diabetes and pregnancy, placenta praevia, abruptio placenta, preterm rupture. Dr. Kovács Kálmán András 4 Contraception. Gynecological inflammations. Sterility testing and management. Dr. Kovács Kálmán András 5 Cancer screening, gynecologic cancers (cervical and endometrial cancer, ovarian cancer). Benign tumors of the uterus (myoma). Dr. Kovács Kálmán András 6 Growth and development during childhood. Dr. Csábi Györgyi 7 Infant nutrition. Dr. Csábi Györgyi 8 The bacterial infections in pediatric care practice. Dr. Csábi Györgyi 9 Exsiccatio, fluid replacement, oral rehydration. Antifebrile therapy, treatment of convulsion. Dr. Csábi Györgyi 10 Neurological disease symptoms, peripheral and central nervous system disorders. Dr. Pál Endre 11 Stroke. Dr. Pál Endre 12 Encephalitis and meningitis, intracranial and spinal tumors. Dr. Pál Endre 13 Multiple sclerosis, Parkinson’s disease, epilepsy. Dr. Pál Endre


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14 Peripheral nervous system diseases, myopathies. Dr. Pál Endre 15 Examination of psychiatric patient. Dr. Tényi Tamás 16 Organic mental disorders. Dr. Tényi Tamás 17 Endogenous psychoses. Dr. Tényi Tamás 18 Non-psychotic psychiatric disorders. Psychiatric therapies. Dr. Tényi Tamás 19 Ear, nose, laryngology. The outer and middle ear. Dr. Bauer Miklós 20 The inner ear. Audiological and vestibular basics. Dr. Bauer Miklós 21 The nose. Dr. Bauer Miklós 22 The pharynx. Dr. Bauer Miklós 23 The larynx, trachea, esophagus and neck. Dr. Bauer Miklós 24 Basics of preventive dentistry, pediatric dentistry. Dr. Balásné Dr. Szántó Ildikó 25 Oral surgery treatments, pain relief. Dr. Balásné Dr. Szántó Ildikó 26 Restorative dental treatments. Dr. Balásné Dr. Szántó Ildikó 27 Basics of prosthodontics. Dr. Balásné Dr. Szántó Ildikó 28 Dental development, orthodontic anomalies, drug-induced dental lesions. Dr. Balásné Dr. Szántó Ildikó 29 Orthopedic examination possibilities, orthopedic screenings, pediatric orthopedic disorders. Dr. Tunyogi Csapó Miklós 30 Large joint diseases and their medical and surgical management Dr. Tunyogi Csapó Miklós 31 Spinal diseases and their conservative and surgical treatment. Dr. Tunyogi Csapó Miklós 32 Joint injuries and their pharmacological and surgical treatment. Dr. Tunyogi Csapó Miklós 33 Orthopedic surgery perioperative complications, prevention, and treatment. Dr. Tunyogi Csapó Miklós 34 Drugs for treatment of urine storage and emptying disorders. Dr. Damásdi Miklós 35 Medical treatment of uro-oncological diseases. Dr. Damásdi Miklós 36 Medical treatment of erectile dysfunction. Dr. Damásdi Miklós 37 Medical aids in urological practice. Dr. Damásdi Miklós 38 Urologic clinics of stone diseases and its drugs. Dr. Damásdi Miklós 39 The structure of skin, essential phenomena. Dr. Kinyó Ágnes 40 Infectious skin disease, pyoderma, bacterial, viral and fungal diseases. Dr. Kinyó Ágnes 41 STD diseases and sexual health care. Dr. Kinyó Ágnes 42 Dermatological tumors. Immunpathological disorders in dermatology. Dr. Kinyó Ágnes


24

43 Eye examination of the patient. (The functional anatomy of the organ of vision, functional and morphological methods of analysis.)

Dr. Varsányi László Balázs 44 Chronic eye diseases (glaucoma, cataracts, age-related macular degeneration, symptomatology, basic examinations,

interpretation of findings, therapy). Dr. Varsányi László Balázs 45 Acute ocular diseases. (Symptomatology, basic examinations, interpretation of findings, therapy). Dr. Varsányi László Balázs 46 Childhood eye diseases. Ocular symptoms of general disorders. Neuroophthalmology. Dr. Varsányi László Balázs 47 Traumatology in ophthalmology and intraocular tumors. Dr. Varsányi László Balázs 48 Treatment of spondylarthritis. Treatment of gout. Treatment of infection-triggered arthritis. Dr. Sütő Gábor 49 Non-biological and biological base therapeutic drugs in rheumatoid arthritis. Dr. Sütő Gábor 50 Rules of the utilization of non steroidal antiinflammatory drugs in rheumatology and clinical immunology. Management of acute

and chronical pain in rheumatology. Dr. Sarlós Gézáné 51 Pharmacological treatment of osteoporosis. Dr. Sarlós Gézáné 52 Treatment with corticosteroids and cytostatic agents in autoimmun diseases. Dr. Czirják László István 53 The primary care of cancer patients, the TNM system, prognostic factors and onkoteam decision. Dr. Mangel László 54 The principles and practice of radiochemotherapy. Dr. Bellyei Szabolcs 55 The clinical implications of chemotherapy and Dr. Karádi Oszkár 56 Modern targeted therapies and basics of hormone replacement therapy. Dr. Karádi Oszkár 57 The practice of supportive therapy in oncology. Dr. Boronkai Árpád 58 Specificity of General Practice, the holistic approach. Dr. Bán Ildikó 59 Physician-pharmacist relationship. Team work. Role-playing. Dr. Ágnes Csikós Dr. Bán Ildikó 60 GP office and staff. Pharmacist-patient relationship. Dr. Bán Ildikó

Practices

Seminars


Written exam based on the lectures.

Participants


25

OPO-KLV CLINICAL LABORATORY INVESTIGATIONS Course director: DR. TAMÁS ANTAL KŐSZEGI, associate professor Institute of Laboratory Medicine

2 credit ▪ midsemester grade ▪ Pharmaceutical Biology and Medical Knowledge module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours Course headcount limitations (min.-max.): 1 – Prerequisites: OPO-KL2 parallel + OPO-IMM completed + OPO-KOT completed

Topic

Clinical Laboratory Investigations is a subject based on a solid knowledge in chemistry, biochemistry and physiology. It gives a practical guide to understand and interpret a wide variety of modern laboratory tests by showing the molecular basis of them. The subject includes classic chemical and biochemical methods, immunochemistry, hematology, blood coagulation, toxicology and molecular biology. The major methodological aspects and applications are discussed during the lectures.



Mid-term exams

A multiple choice mid-term is due in October.


An absence rate of less than 25% is acceptable, no medical or other certificate is necessary.

Reading material



All lectures are accessible at Coospace

- Notes


W.J. Marshall, S.K. Bangert: Clinical Chemistry, 5th ed., Mosby Co, 2004, ISBN 0723433283 G.J. Beckett, S.W. Walker, P. Rae, P. Ashby: Lecture Notes on Clinical Biochemistry, 7th ed., Blackwell Co., 2005 W.J. Marshall, S.K. Bangert: Clinical Chemistry, 6th ed., Mosby Co, 2008 ISBN 9780723434559

Lectures

1 Clinical Biochemistry: analysis of samples obtained from the human body and interpretation of test results. Different factors influencing the results of lab tests. Informational value of test results (reference intervals, statistical approaches).

Dr. Kőszegi Tamás Antal 2 Clinical Biochemistry: analysis of samples obtained from the human body and interpretation of test results. Different factors

influencing the results of lab tests. Informational value of test results (reference intervals, statistical approaches). Dr. Kőszegi Tamás Antal 3 Different laboratory approaches in water and electrolyte disorders. Internal and external quality controls. Dr. Kőszegi Tamás Antal 4 Different laboratory approaches in water and electrolyte disorders. Internal and external quality controls. Dr. Kőszegi Tamás Antal 5 Analysis of plasma proteins. Separation techniques and basis of immunochemical methods. Dr. Kőszegi Tamás Antal 6 Analysis of plasma proteins. Separation techniques and basis of immunochemical methods. Dr. Kőszegi Tamás Antal 7 Analysis of plasma enzymes. Routes of release of enzymes into the extracellular space. Enzymes as tissue markers. Dr. Kőszegi Tamás Antal 8 Analysis of plasma enzymes. Routes of release of enzymes into the extracellular space. Enzymes as tissue markers. Dr. Kőszegi Tamás Antal 9 Carbohydrate metabolism and laboratory tests in endocrine diseases. Dr. Kőszegi Tamás Antal 10 Carbohydrate metabolism and laboratory tests in endocrine diseases. Dr. Kőszegi Tamás Antal


26

11 Laboratory diagnostics of cardiac and skeletal muscle diseases. Inherited and acquired disorders. Importance of the half-life of tested parameters.

Dr. Kőszegi Tamás Antal 12 Laboratory diagnostics of cardiac and skeletal muscle diseases. Inherited and acquired disorders. Importance of the half-life of

tested parameters. Dr. Kőszegi Tamás Antal 13 Iron, porphyrin and hemoglobin metabolism. Automated immunochemical measurements. Dr. Kőszegi Tamás Antal 14 Iron, porphyrin and hemoglobin metabolism. Automated immunochemical measurements. Dr. Kőszegi Tamás Antal 15 Disorders of lipid metabolism. Automated hematological analyses. Dr. Kőszegi Tamás Antal 16 Disorders of lipid metabolism. Automated hematological analyses. Dr. Kőszegi Tamás Antal 17 Acid-base balance. Methods and interpretation of test results. Dr. Kőszegi Tamás Antal 18 Acid-base balance. Methods and interpretation of test results. Dr. Kőszegi Tamás Antal 19 Calcium, magnesium and bone metabolism. Laboratory findings in bone diseases. Dr. Kőszegi Tamás Antal 20 Calcium, magnesium and bone metabolism. Laboratory findings in bone diseases. Dr. Kőszegi Tamás Antal 21 Laboratory tests in kidney diseases. Tumors and tumor markers. Dr. Kőszegi Tamás Antal 22 Laboratory tests in kidney diseases. Tumors and tumor markers. Dr. Kőszegi Tamás Antal 23 Different approaches in liver and gastrointestinal diseases. Basic methods in investigation of disorders in hemostasis. Dr. Kőszegi Tamás Antal 24 Different approaches in liver and gastrointestinal diseases. Basic methods in toxicology and interpretation of results. Dr. Kőszegi Tamás Antal

Practices

Seminars


In every new semester new multiple choice questions are to be worked out.

Participants


27

OPS-SG3 PROFESSIONAL PRACTICE BEFORE STATE EXAMINATION 1 Course director: DR. KLÁRA MAYER, assistant professor Department of Pharmacotechnology

4 credit ▪ midsemester grade ▪ Final/Rotational (year) module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 0 lectures + 320 practices + 0 seminars = total of 320 hours Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-GH1 completed + OPG-GI2 completed + OPR-SG2 completed

Topic

Two month of course Pharmacy Practice 3 is the first part of the 6 month of practice in the rigorous year. Aim of the first part of rigorous year is to expand the knowledge and approach of student with practice oriented pharmaceutics, knowing the aspects of pharmaceutical care, economy and preparing magistral medicines in the pharmacy. The 6 months are the 6 thematic, from this 1-3 parts must in the 2 months 2 part in the Professional Practice Before state Examination I. The practice 2 months can be homeland or Hungarian or foreign countries pharmacy.


Brief daily report must be done during the practice which has to be presented. Tutor pharmacist and chief pharmacist has to evaluate students work and confirm the pharmacy practice with their signature. Student must work daily 8 hours during two month of practice.

Proposal in the Hungarian pharmacy practice with Hungarian Student together.

Mid-term exams

Brief daily report must be done during the practice which has to be presented on course of Institute of Pharmaceutical Technology and Biopharmacy in the Semester 9.


During the 6 months practice only 5 days are allowed to miss confirmed by a physician. More days of missing must be supplemented.

Reading material


Dévay: The Theory and Practice of Pharmaceutical Technology, e-book, http://gytsz.pte.hu/en/egyseg/oktatasianyagok/1620/


- Notes

Final exam - test-book


European Pharmacopoeia Pharmacopoeia Hungarica Hungarian National Formulary: Formulae Normales VII (FoNo VII) Compendium

Lectures

Practices

1.a) Clinical Pharmacy 1. parts Knowing the structure of hospital/clinic Studying the relationship between the pharmacy and other wards Controlling role of the pharmacy regarding drug utilization and storage of different wards Federal laws affecting clinical pharmacy practice Preparing drugs specified for clinical pharmacies under the supervision of the tutor pharmacist Knowing and operating with special appliances on different divisions (galenic division, parenteral division) of the pharmacy

under the supervision of the tutor pharmacist Knowing basic galenic preparations of the pharmacy containing knowledge of preparation of infusions, peritoneal dialysis

solutions; knowing the conditions for preparations, analytical and microbiological control methods and storage Recognizing and repairing incompatibilities Participating in economical tasks of the pharmacy Pharmaceutical economy, ordering medicines Studying drugs, medical aids, nutritions, diagnostics, x-ray contrast materials stored in pharmacy Studying relationship with pharmaceutical manufacturers and distributors Studying drug order from foreign countries


28

Treatment of drugs and ingredients of increased control Studying participation of the pharmacy in the therapy Knowing the intelligence service of the pharmacy Studying role and function of Board of Pharmaceutical Therapy, knowing its protocols Studying drug development clinical trials, knowing the documentation, federal laws regarding clinical trials Studying the relationship between the pharmacy and the clinical laboratory

„Clinical pharmacy 2. parts” 2. Public pharmacy operation Public pharmacies’ measures concerning drug supply In the pharmacy’s farming tasks truth participation The acquisition of management, technical knowledge Medicine farming: the procession of the medicine order The preparation of medicine orders Contacts, information, the examination of orders, complaints lasted with the medicine wholesalers With the implements to be checked increased related knowledge and tasks In the course of the waste product, the returns, a damage truth tasks It is related to changes in price tasks The closings: daily, weekly, snow end ill. OEP meanings The knowledge of measures, bulletins A drawer pharmacy’s, „kézigyógyszertár” concepts, knowledge, tasks The knowledge of the officinal literature The acquisition of the officinal computer program with a skill level 3. Pharmaceutical practice, receipt, preparate The accomplishment of the medicine making processes turning up in the pharmacy with the management of a teaching chemist The pharmacy’s inner cheque activity in the process of the medicine making Unique praescriptions his cognition, his completion, their comparison the official one with praescriptions Pharmacopoeia, FoNo Laboration concept, the differences of processes, completions the unique one prescriptions his making, documentation His Manual cognition, his application and prescription his editing The nomenclature of the stocks, regular pharmacopoeia full Latin ill. his abridged name Medicine cheque: the incoming medicines, stocks, basis artefacts, vegetal drugs, bandages, etc. His regular receipt The the examination of stocks and his documentation arrived The laboured the cheque of artefacts (pl. 70% Ethanolum, Sirup. simplex) The aseptic working in the pharmacy, a principle, practice Sterile, documentation, sterile apparatus cheque The recognition of incompatibilities, correct completions, physical, chemistry, kolloidikai the reasons of incompatibilities and

technological solutions 1.b) ”Clinical pharmacy 2. parts” Directives of the pharmacy Studying pharmaceutical literature Knowing reagents applied in diagnostics including preparation Treatment of biological samples, basic clinical examinations, normal levels Knowing other special tasks of the pharmacy (e.g.: measurement of drug concentration in plasma) Knowing basic databases used in clinical pharmacy Knowing the quality assurance of the hospital emphasizing the regulations regarding the pharmacy Controlling role of the pharmacy regarding drug utilization and storage of different wards Federal laws affecting clinical pharmacy practice Preparing drugs specified for clinical pharmacies under the supervision of the tutor pharmacist Participating in works on different divisions of the pharmacy (labelling, packaging, etc.) Knowing and operating with special appliances on different divisions (galenic division, parenteral division) of the pharmacy


solutions; knowing the conditions for preparations, analytical and microbiological control methods and storage Preparation of complex infusions (cytostatic infusions, parenteral nutrition infusions) Knowing and preparation of special magistral formulas, comparing with official formulas of FoNo VII. or Manuale

Pharmaceuticum


29

Recognizing and repairing incompatibilities Participating in economical tasks of the pharmacy Studying drugs, medical aids, nutritions, diagnostics, x-ray contrast materials stored in pharmacy Participating in ordering of drugs on-line and off-line Studying relationship with pharmaceutical manufacturers and distributors Studying drug order from foreign countries Treatment of drugs and ingredients of increased control Studying participation of the pharmacy in the therapy Knowing the intelligence service of the pharmacy Studying role and function of Board of Pharmaceutical Therapy, knowing its protocols Studying drug development clinical trials, knowing the documentation, federal laws regarding clinical trials Studying the relationship between the pharmacy and the clinical laboratory Knowing reagents applied in diagnostics including preparation Treatment of biological samples, basic clinical examinations, normal levels Knowing other special tasks of the pharmacy (e.g.: measurement of drug concentration in plasma) Studying pharmaceutical literature Knowing basic databases used in clinical pharmacy Knowing the system of quality assurance Knowing the quality assurance of the hospital emphasizing the regulations regarding the pharmacy

Seminars


Knowledge acquired is evaluated based on reports made during pharmacy practice and the evaluation of the tutor/chief pharmacist.

Participants

Dr. Mayer Klára (MAKMABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Rezesné dr. Börzsei Rita Judit (BORPAAO.PTE)


30

OPS-SG4 PROFESSIONAL PRACTICE BEFORE STATE EXAMINATION 2 Course director: DR. KLÁRA MAYER, assistant professor Department of Pharmacotechnology

14 credit ▪ midsemester grade ▪ Final/Rotational (year) module ▪ spring semester ▪ recommended semester: 10 Number of hours/semester: 0 lectures + 640 practices + 0 seminars = total of 640 hours Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OGG-HT3 completed + OPG-UI4 completed + OPG-GT4 completed

Topic

Aim of the first part of rigorous year is to expand the knowledge and approach of student with practice oriented pharmaceutics, knowing the aspects of pharmaceutical care, economy and preparing medicines both in the public pharmacy (3 months)and in clinical/hospital (1 months) pharmacies. This course is expanded with practice in clinical/hospital pharmacies in order to learn the tasks and connections of the pharmacy with other wards of the hospital. The 6 months have 6 thematics, one thematic 1-1 months time. Proposal in the Hungarian pharmacy practice with Hungarian Student together.


Brief daily report must be done during the practice which has to be presented. Tutor pharmacist and chief pharmacist has to evaluate students work and confirm the pharmacy practice with their signature. Student must work daily 8 hours during two month of practice.

The practice 4 months must in the Hungarian pharmacy.

Mid-term exams

Brief daily report must be done during the practice which has to be presented or the Institute of Pharmaceutical Technology and Biopharmacy in the Semester 10 or the Registrar’s Office.


During the 6 months practice only 5 days are allowed to miss confirmed by a physician. More days of missing must be supplemented.

Reading material


Dévay: The Theory and Practice of Pharmaceutical Technology, e-book, http://gytsz.pte.hu/en/egyseg/oktatasianyagok/1620/


- Notes

Final exam - test-book


European Pharmacopoeia Pharmacopoeia Hungarica Hungarian National Formulary: Formulae Normales VII (FoNo VII) Compendium

Lectures

Practices

1. Clinical pharmacy Knowing the structure of hospital/clinic Studying the relationship between the pharmacy and other wards Controlling role of the pharmacy regarding drug utilization and storage of different wards Federal laws affecting clinical pharmacy practice Preparing drugs specified for clinical pharmacies under the supervision of the tutor pharmacist Participating in works on different divisions of the pharmacy (labelling, packaging, etc.) Knowing and operating with special appliances on different divisions (galenic division, parenteral division) of the pharmacy


solutions; knowing the conditions for preparations, analytical and microbiological control methods and storage Recognizing and repairing incompatibilities Participating in economical tasks of the pharmacy Pharmaceutical economy, ordering medicines Studying drugs, medical aids, nutritions, diagnostics, x-ray contrast materials stored in pharmacy


31

Participating in ordering of drugs on-line and off-line Studying relationship with pharmaceutical manufacturers and distributors Studying drug order from foreign countries Treatment of drugs and ingredients of increased control Studying participation of the pharmacy in the therapy Knowing the intelligence service of the pharmacy Studying role and function of Board of Pharmaceutical Therapy, knowing its protocols Studying drug development clinical trials, knowing the documentation, federal laws regarding clinical trials Studying the relationship between the pharmacy and the clinical laboratory Directives of the pharmacy Studying pharmaceutical literature Knowing reagents applied in diagnostics including preparation Treatment of biological samples, basic clinical examinations, normal levels Knowing other special tasks of the pharmacy (e.g.: measurement of drug concentration in plasma) Knowing basic databases used in clinical pharmacy Knowing the quality assurance of the hospital emphasizing the regulations regarding the pharmacy Controlling role of the pharmacy regarding drug utilization and storage of different wards Federal laws affecting clinical pharmacy practice Preparing drugs specified for clinical pharmacies under the supervision of the tutor pharmacist Participating in works on different divisions of the pharmacy (labelling, packaging, etc.) Knowing and operating with special appliances on different divisions (galenic division, parenteral division) of the pharmacy


solutions; knowing the conditions for preparations, analytical and microbiological control methods and storage Preparation of complex infusions (cytostatic infusions, parenteral nutrition infusions) Knowing and preparation of special magistral formulas, comparing with official formulas of FoNo VII. or Manuale

Pharmaceuticum Recognizing and repairing incompatibilities Participating in economical tasks of the pharmacy Studying drugs, medical aids, nutritions, diagnostics, x-ray contrast materials stored in pharmacy Participating in ordering of drugs on-line and off-line Studying relationship with pharmaceutical manufacturers and distributors Studying drug order from foreign countries Treatment of drugs and ingredients of increased control Studying participation of the pharmacy in the therapy Knowing the intelligence service of the pharmacy Studying role and function of Board of Pharmaceutical Therapy, knowing its protocols Studying drug development clinical trials, knowing the documentation, federal laws regarding clinical trials Studying the relationship between the pharmacy and the clinical laboratory Knowing reagents applied in diagnostics including preparation Treatment of biological samples, basic clinical examinations, normal levels Knowing other special tasks of the pharmacy (e.g.: measurement of drug concentration in plasma) Studying pharmaceutical literature Knowing basic databases used in clinical pharmacy Knowing the system of quality assurance Knowing the quality assurance of the hospital emphasizing the regulations regarding the pharmacy … 2. Public pharmacy operation Public pharmacies’ measures concerning drug supply In the pharmacy’s farming tasks truth participation The acquisition of management, technical knowledge Medicine farming: the procession of the medicine order The preparation of medicine orders, Contacts, information, the examination of orders, complaints lasted with the medicine wholesalers With the implements to be checked increased related knowledge and tasks In the course of the waste product, the returns, a damage truth tasks It is related to changes in price tasks The closings: daily, weekly, snow end ill. OEP meanings


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The knowledge of measures, bulletins A drawer pharmacy’s, „kézigyógyszertár” concepts, knowledge, tasks The knowledge of the officinal literature The acquisition of the officinal computer program with a skill level

…

3. Pharmaceutical practice, receipt, preparate The accomplishment of the medicine making processes turning up in the pharmacy with the management of a teaching chemist The pharmacy’s inner cheque activity in the process of the medicine making Unique praescriptions his cognition, his completion, their comparison the official one with praescriptions (Pharmacopoeia, FoNo) Laboration concept, the differences of processes, completions the unique one prescription his making, documentation His Manual cognition, his application and előirat his editing The nomenclature of the stocks, regular pharmacopoeia full Latin ill. his abridged name Medicine cheque: the incoming medicines, stocks, basis artefacts, vegetal drugs, bandages, etc. his regular receipt The examination of stocks and his documentation arrived The laboured the cheque of artefacts (pl. 70% Ethanolum, Sirup. simplex) The aseptic working in the pharmacy, a principle, practice Sterile, documentation, sterile apparatus cheque The recognition of incompatibilities, correct completions, physical, chemistry, kolloid reasons of incompatibilities and

technological solutions .. 4. Medicine wholesale (expedition), officinal quality assurance The pharmacy’s inner cheque activity in the processes of the medicine wholesale The acquisition of the officinal computer program with a skill level The categories of storage, storage, his documentations, the cold chain chekd his process The cognition of the medicines, replaceabilities, strength / cross marks The prescription in the case of his regularity, formal deficiencies the tasks The treatment of veterinary science prescriptions The artefacts which can be received without the prescription (OTC) his concept, knowledge, dispatching The groups of products which can be distributed in a pharmacy, his knowledge The recognition of incompatibilities, on emphasized one the pharmacology incompatibilities, tasks, solution opportunities Solutions according to Polipragmazia cognition, hygienic viewpoints – contact with doctors, patients The expense of artefacts to be checked increased, his documentations The significance of the retaxa and his practice Correct communication towards the patients in a principle and the practice The knowledge of the officinal quality assurance system ... 5. Medicine - pharmaceutical review Officinal literature, technical books the knowledge of journals, his availability Correct communication towards the hygienic specialists Hygienic counsel towards different age groups (school, caretaker at home) Pedigreed medicines, nutritions, bandages, therapeutic equipment, his knowledge The artefacts which can be received without the prescription (OTC) his concept, knowledge, dispatching The groups of products which can be distributed in a pharmacy, his knowledge For the officinal employees medicine review from an actual artefact (recording, in the framework of inner professional

development) The correct assessment of homoeopathic prescriptions, products, his conceptual and practical knowledge .. 6. Pharmacist nurture The cognition of the legal regulation being attached to the chemist nurture The levels of the chemist nurture, the conditions of his order

Pharmaceutical Nurture Committee characters, his tasks Good Pharmacy Practice (GPP) the knowledge of his governing principles Elementary level chemist medicine safety cheque made in the framework of nurture vocational governing principle applying his

knowledge and practical one


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For the International Classification of the illnesses (in Hungarian BNO) his knowledge BNO being found the most mostly the cognition of codes The resuscitation of the pathologic and clinical knowledge of illnesses Self-therapy the information of his concept, his practice, patients Officinal literature, technical books the knowledge of journals, his availability ..

Seminars


Knowledge acquired is evaluated based on reports made during pharmacy practice and the evaluation of the tutor/chief pharmacist.

Participants

Dr. Mayer Klára (MAKMABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Rezesné dr. Börzsei Rita Judit (BORPAAO.PTE)

STUDY PROGRAM 2015/2016 Subjects of the 9-10. semesters ...

Documents

Transcript of STUDY PROGRAM 2015/2016 Subjects of the 9-10. semesters ...