STUDY PROGRAM 2021/2022 Subjects of the 7-8. semesters ...

UP FP Pharmacy major – Obligatory subjects in the 7-8. rec. semester - Course descriptions – academic year of 2021/2022

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University of Pécs Faculty of Pharmacy

PHARMACY Major

STUDY PROGRAM 2021/2022

Subjects of the 7-8. semesters

(obligatory subjects and criterion requirements)


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Table of Contents

7th semester

OPG-C3E-T Pharmaceutical Technology 3 - Theory ____________________________________________________________ 3

OPG-C3G-T Pharmaceutical Technology 3 - Practice____________________________________________________________ 5

OPG-D1E-T Pharmacodynamics 1 - Theory ___________________________________________________________________ 8

OPG-D1G-T Pharmacodynamics 1 - Practice _________________________________________________________________ 11

OPG-GAI-T Pharmaceutical Applied Immunology ____________________________________________________________ 13

OPG-GI2-T Pharmaceutical Practice and Management 1 _______________________________________________________ 15

OPG-PPA-T Pharmaceutical Pathology _____________________________________________________________________ 18

OPG-R3E-T Pharmaceutical Chemistry 3 - Theory ____________________________________________________________ 20

OPG-R3G-T Pharmaceutical Chemistry 3 - Practice ____________________________________________________________ 23

OPO-KE1-T Public Health 1 ______________________________________________________________________________ 26

8th semester

OPG-C4E-T Pharmaceutical Technology 4 - Theory ___________________________________________________________ 28

OPG-C4G-T Pharmaceutical Technology 4 - Practice___________________________________________________________ 30

OPG-D2E-T Pharmacodynamics 2 - Theory __________________________________________________________________ 32

OPG-D2G-T Pharmacodynamics 2 - Practice _________________________________________________________________ 35

OPG-GBI-T Pharmaceutical Biotechnology __________________________________________________________________ 37

OPG-KL1-T Clinical Studies 1 ____________________________________________________________________________ 39

OPG-R4E-T Pharmaceutical Chemistry 4 - Theory ____________________________________________________________ 41

OPG-R4G-T Pharmaceutical Chemistry 4 - Practice ____________________________________________________________ 43

OPG-TXA-T Toxicology _________________________________________________________________________________ 46

OPG-U3E-T Pharmaceutical Practice and Management 2 - Theory ________________________________________________ 49

OPG-U3G-T Pharmaceutical Practice and Management 2 - Practice _______________________________________________ 53

OPO-KE2-T Public Health 2 ______________________________________________________________________________ 55


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OPG-C3E-T PHARMACEUTICAL TECHNOLOGY 3 - THEORY

Course director: DR. SZILÁRD PÁL, assistant professor

Institute of Pharmaceutical Technology and Biopharmacy [email protected]

2 credit ▪ semester exam ▪ Pharm. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 7

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 1 – 80 Prerequisites: see your Recommended Curriculum

Topic

Mainly semisolid dosage forms are prepared in this semester: suppositories and vaginal suppositories. Powders and capsules as solid

dosage forms are also prepared and discussed.

Conditions for acceptance of the semester

Code of Studies and Regulations

Mid-term exams

Students have to write three assessments during the semester and they have to reach 60 % after average calculation. After two assessments

if students reach average 60 % taking into account both tests, writing the third assesment it not compulsory. The third assessments (which

is considered as the 1st retake) has to above 60,1 %. If the student fails on the 3rd assessment, there is still chance for the 2nd retake,

where student has to reach 60,1% for the acceptance of the semester. In case of confirmed absence from the assessment, re-take chance

is sossible for the student. Missing the re-take results 0 % assessment.

Making up for missed classes

Students must fulfil requirements determined by the Code of Studies and Examinations.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

European Pharmacopoeia

Formulae Normales VII. (FoNo VII.)

James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press

www.gytk.pte.hu

www.sciencedirect.com

Attila Dévay: The Theory and Practice of Pharmaceutical Technology, electronic book, PTE-Pécs

Attila Dévay: Investigation of Pharmaceutical Preparations, electronic book, PTE-Pécs

Lectures

1 Crystallisation, polymorphism, and their technological aspects

Dr. Secenji Aleksandar

2 Crystallisation, polymorphism, and their technological aspects


3 Drying, freeze-drying


4 Drying, freeze-drying


5 Grinding and shieving

Dr. Pál Szilárd

6 Grinding and shieving

Dr. Pál Szilárd

7 Preparation of granules I

Dr. Pál Szilárd

8 Preparation of granules I

Dr. Pál Szilárd

9 Preparation of granules II

Dr. Pál Szilárd

http://www.gytk.pte.hu/

http://www.sciencedirect.com/


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10 Written test

Dr. Pál Szilárd

11 Fluidization and its application

Dr. Kása Péter

12 Fluidization and its application

Dr. Kása Péter

13 Pharmaceutical excipients of granules

Dr. Pál Szilárd

14 Pharmaceutical excipients of granules

Dr. Pál Szilárd

15 Tabletting I

Dr. Pál Szilárd

16 Tabletting I

Dr. Pál Szilárd

17 Tabletting II (excipients, examinations)

Dr. Pál Szilárd

18 Tabletting II (excipients, examinations)

Dr. Pál Szilárd

19 Excipients for the preparation of tablets and granules

Dr. Pál Szilárd

20 Written test

Dr. Pál Szilárd

21 Coating of preparations

Dr. Kása Péter

22 Coating of preparations

Dr. Kása Péter

23 Pharmaceutical capsules

Dr. Pál Szilárd

24 Pharmaceutical capsules

Dr. Pál Szilárd

25 Written test

Dr. Pál Szilárd

26 Written test

Dr. Pál Szilárd

27 Inhaled drug delivery systems

Dr. Kása Péter

28 Inhaled drug delivery systems

Dr. Kása Péter

Practices

Seminars

Exam topics/questions

The end-semester exam will be evaluated by a five-grade system.

Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute.

At the end of semester, students take written exam. The date of "A" chance exam is in determined date for students finishing the course.

Chance "B" and "C"are oral exams, which is preceded by the "Minimum Test" (MT). To write the MT, students have at most 30

minutes, and will be evaluated percent rating. Those students, who achieve less than 60% in MT, unsatisfactory grade will be assessed

and cannot pass them to the oral part of the exam.

Oral part includes two topics. In the case of any part done with insufficient knowledge, will result in assessment of the exam to

unsatisfactory grade.

In addition to the exam topics, part of the exam is answering questions that aim at assessing the general knowledge of the student.

Participants


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OPG-C3G-T PHARMACEUTICAL TECHNOLOGY 3 - PRACTICE



5 credit ▪ midsemester grade ▪ Pharm. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 7



Topic

Mainly semisolid dosage forms are prepared in this semester: suppositories and vaginal suppositories. Powders and capsules as solid

dosage forms are also prepared and discussed.


1. Accepted preparations made on practices.

2. Accepted work reports.

3. Accepted practical and theoretical assessments.

4. At the beginning of all practice classes students write short tests of different types (dose checking, synonim names and latin

expressions, calculations). Semester only can be accepted if students reach at least 50% from each short test type.

Mid-term exams

Students have to participate two practice tests.



All missed or failed preparations manufactured on the practice should be made up on supplementary practices!

Reading material



- Notes







www.gytk.pte.hu




Lectures

Practices

1 Sugar and film coating process





2 End semester assessment





3 General instructions, rules and regulations on practices, introduction to solid forms







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4 Undivided (bulk) powders, dusting powders, species I





5 Undivided (bulk) powders, dusting powders, species II





6 Divided powders I

6 Divided powders I

6 Divided powders I

6 Divided powders I

6 Divided powders I

7 Divided powders II





8 Dusting powders

8 Dusting powders

8 Dusting powders

8 Dusting powders

8 Dusting powders

9 Pills, hard gelatin capsules





10 Assessment

10 Assessment

10 Assessment

10 Assessment

10 Assessment

11 Preparation of garnules I, drying





12 Preparation of garnules II, examinations





13 Tabletting I., Machines





14 Tabletting II., Direct compression






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Seminars


Website of the Institute.

Participants

Dr. Ferenczi Krisztina (I8U2DJ), Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (FYF5E9), Kopcsányi Márton (D3S7AX)


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OPG-D1E-T PHARMACODYNAMICS 1 - THEORY

Course director: DR. GÁBOR ISTVÁN PETHŐ, professor

Department of Pharmacology [email protected]




Topic

The aim of the course is to provide the students with the pharmacological knowledge required for their future work in the field of

pharmacy. Important topics are the general principles of pharmacodynamics and pharmacokinetics, pharmacology of the autonomic

nervous system and the cardiovascular system.


Maximum of 25 % absence allowed

Mid-term exams

There is no midterm exam/test.


There is no way to make up for missed classes.

Reading material



Electronic handouts are provided for most topics.

- Notes


Rang, Dale, Ritter, Moore: Pharmacology, 9th edition, Elsevier Churchill Livingstone, 2019

B. G. Katzung (ed.): Basic and Clinical Pharmacology, 14th edition, Lange Medical Books/McGraw-Hill, 2018

Lectures

1 Introduction to neuropharmacology. General characterization of the autonomic nervous system

Dr. Barthó Loránd

2 Cholinergic agonists

Dr. Barthó Loránd

3 Cholinesterase inhibitors I

Dr. Barthó Loránd

4 Cholinesterase inhibitors II

Dr. Barthó Loránd

5 Muscarinic receptor antagonists I

Dr. Barthó Loránd

6 Muscarinic receptor antagonists II

Dr. Barthó Loránd

7 Neuromuscular blocking agents I

Dr. Pethő Gábor István

8 Neuromuscular blocking agents II


9 Agents acting on biosynthesis, storage, release and elimination of catecholamines I


10 Agents acting on biosynthesis, storage, release and elimination of catecholamines II


11 Adrenergic receptor agonists I


12 Adrenergic receptor agonists II


13 Adrenergic receptor antagonists I



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14 Adrenergic receptor antagonists II


15 Pharmacology of the calcium channels I


16 Pharmacology of the calcium channels II


17 Drugs acting on the renin-angiotensin-aldosterone system I

Dr. Poór Miklós

18 Drugs acting on the renin-angiotensin-aldosterone system II

Dr. Poór Miklós

19 Diuretic drugs I


20 Diuretic drugs II


21 Drugs used for treating congestive heart failure I

Dr. Börzsei Rita Judit

22 Drugs used for treating congestive heart failure II


23 Antiarrhythmic drugs I


24 Antiarrhythmic drugs II


25 Antianginal drugs I


26 Antianginal drugs II. Drugs increasing regional blood flow


27 Antihypertensive drugs I


28 Antihypertensive drugs II


Practices

Seminars


Reqirements: the exams are oral, the required topics are dealt with during the semester lectures and practical classes. The criterion of

admission to the exam is the successful completion of the Pharmacodynamics 1 practice course carried out in paralell (at least

satisfactory midsemester grade).

Exam questions:

1. Basic mechanisms of drug actions

2. Characterization of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy

3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs

4. Mechanisms of drug antagonisms

5. Transport of drugs across membranes

6. Absorption of drugs, oral bioavailability and presystemic elimination

7. Distribution of drugs

8. Biotransformation of drugs

9. Excretion of drugs

10. Pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability,

calculation of loading and maintenance doses

11. Cholinergic agonists and cholinesterase inhibitors

12. Muscarinic receptor antagonists

13. Neuromuscular blocking agents. Drugs acting on autonomic ganglia

14. Agents acting on the biosynthesis, storage, release and elimination of catecholamines

15. Adrenergic receptor agonists

16. Adrenergic receptor antagonists

17. Local anaesthetics

18. Calcium channel blockers

19. Drugs acting on the renin-angiotensin-aldosterone system


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20. Diuretic drugs

21. Positive inotropic and other drugs used to treat congestive heart failure

22. Antianginal drugs. Drugs that increase regional blood flow

23. Antihypertensive drugs

24. Antiarrhythmic drug

In addition to the exam topics, an important part of the exam is answering questions that aim at assessing the general knowledge of the

student.

Participants


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OPG-D1G-T PHARMACODYNAMICS 1 - PRACTICE






Topic

The aim of the course is to provide the students with the pharmacological knowledge required for their future work in the field of

pharmacy. Important topics are the general principles of pharmacodynamics and pharmacokinetics.



Mid-term exams

The students receive a practice grade based on their performance during the semester. The grade will be registered in the Neptun as a

midsemester grade. The grade must be at least satisfactory as a prerequisite for taking the semester exam. Around the 11th week of the

semester, a written test is the base of the practice grade. The test covers the subjects of practice classes of the first 10 weeks of the

semester and 50% of the available points must be reached for acceptance of the semester. Should someone fail or want to improve, they

can do it one time before the end of the semester. On a final failure (that is, after the improvement attempt still below 50%), the student

cannot have semester accepted.



Reading material




- Notes




Lectures

Practices

1 Introduction to pharmacodynamics I.


2 Introduction to pharmacodynamics II.


3 Basic mechanisms of drug actions

Dr. Faisal Anna Zelma

4 Characterization of the agonist-receptor interaction I.


5 Characterization of the agonist-receptor interaction II.

Hartnerné Dr. Pohóczky Krisztina

6 Characterization of the agonist-receptor interaction III.


7 Signal transduction mechanisms of drug receptors

Dr. Mohos Violetta Karolin

8 Tachyphylaxis and tolerance


9 Mechanisms of drug antagonisms I.


10 Mechanisms of drug antagonisms II.


11 Transport of drugs across membranes

Dr. Fliszár-Nyúl Eszter


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12 Absorption of drugs I.


13 Absorption of drugs II. Binding of drugs to plasma proteins

Dr. Poór Miklós

14 Distribution of drugs

Dr. Poór Miklós

15 Biotransformation of drugs I.

Dr. Poór Miklós

16 Biotransformation of drugs II.

Dr. Poór Miklós

17 Biotransformation of drugs III.

Dr. Poór Miklós

18 Excretion of drugs

Dr. Poór Miklós

19 Pharmacokinetic parameters I.


20 Pharmacokinetic parameters II.


21 Local anesthetics I.


22 Local anesthetics II.


23 Drugs acting on autonomic ganglia


24 Theoretical basis of the modulation of the pharmacology of the automatic nervous system


25 Discussion of the pharmacology of the parasympathetic nervous system I.

Dr. Barthó Loránd

26 Discussion of the pharmacology of the parasympathetic nervous system II.

Dr. Barthó Loránd

27 Discussion of the pharmacology of the sympathetic nervous system I.

Dr. Barthó Loránd

28 Discussion of the pharmacology of the sympathetic nervous system II.

Dr. Barthó Loránd

Seminars


1. Basic mechanisms of drug actions

2. Characterization of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy

3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs

4. Mechanisms of drug antagonisms

5. Transport of drugs across membranes

6. Absorption of drugs, oral bioavailability and presystemic elimination

7. Distribution of drugs

8. Biotransformation of drugs

9. Excretion of drugs

10. Pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability,

calculation of loading and maintenance doses

Participants

Dr. Barthó Loránd (DK1RNK), Dr. Faisal Anna Zelma (KVG5NA), Dr. Fliszár-Nyúl Eszter (TUOYWS), Dr. Mohos Violetta Karolin

(K9WTSC), Dr. Pethő Gábor István (F2YVEE), Dr. Poór Miklós (ARWF5Z), Hartnerné Dr. Pohóczky Krisztina (OX02SO)


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OPG-GAI-T PHARMACEUTICAL APPLIED IMMUNOLOGY

Course director: DR. JUDIT ERZSÉBET PONGRÁCZ, professor

Department of Pharmaceutical Biotechnology [email protected]




Topic

Immunology from a pharmaceutical aspect. The course material is designed to provide theoretical background to the effects of currently

employed drugs on the immune system. The course will discuss the latest advances in understanding of immune cells after treatment

with various medicines including antimicrobials, cancer drugs, etc. and how these drugs modify the immune response to aid or inhibit

recovery from a particular disease.



Mid-term exams

Written test


According to the Code of Studies and Examinations.

Reading material



Lecture and seminar ppt

- Notes

Lecture notes, learning materials of the lectures are available on MeetStreet

Pharmaceutical Applied Immunology 2019


Lectures

1 Immunology: a pharmaceutical perspective – Immune effects of drugs acting on the nervous system

Dr. Pongrácz Judit Erzsébet

2 Bacterial infection – Effects of antibiotics on the immune system


3 Viral infection I. – Effects of antiviral drugs on the immune system


4 Viral infection II. – Effects of antiviral drugs on the immune system


5 Parasite infection – Effects of anti-parasitic drugs on the immune system


6 Fungal infection – Effects of antifungal drugs on the immune system


7 Vitamins and the immune system – Effects of vitamins on the immune system


8 Tumors and immunotherapy – Effects of chemotherapy on the immune system


9 Tumors and immunotherapy – Immunological agents used in cancer therapy and their effects on the immune system


10 Hypersensitive reactions I. – Immune effects of drugs used in the therapy of hypersensitivity reactions


11 Hypersensitive reactions II. – Immune effects of drugs used in the therapy of hypersensitivity reactions


12 Vaccination – Effects of vaccines on the immune system


13 Novel therapies using the immune system



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14 Personalized therapies


Practices

Seminars

1 Immune effects of drugs acting on the nervous system

Elhusseiny Mohamed Mahmoud

2 Effects of antibiotics on the immune system


3 Effects of antiviral drugs on the immune system I


4 Effects of antiviral drugs on the immune system II


5 Effects of anti-parasitic drugs on the immune system


6 Fungal infection – Effects of antifungal drugs on the immune system


7 Effects of vitamins on the immune system


8 Effects of chemotherapy on the immune system


9 Immunological agents used in cancer therapy and their effects on the immune system


10 Immune effects of drugs used in the therapy of hypersensitivity reactions I


11 Immune effects of drugs used in the therapy of hypersensitivity reactions II


12 Effects of vaccines on the immune system


13 Novel therapies using the immune system


14 Personalized therapies



MeetStreet

Participants

Abdelwahab Elhusseiny Mohamed Mahmoud (ZYY8OB)


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OPG-GI2-T PHARMACEUTICAL PRACTICE AND MANAGEMENT 1

Course director: DR. LAJOS BOTZ, professor

Department of Pharmaceutics and University Pharmacy [email protected]




Topic

The topics of the semester introduce the basic functioning of the pharmaceutical and health-care market, further the basic fundamentals

of economics relevant for pharmacy students. Methods of comprehensive analysis, evaluation and development of drug therapy,

healthcare systems, the framework and regulation of pharmaceutical supply will be covered throughout the semester. Interactive

discussions will cover essential topics regarding self-medication and over the counter products used in minor diseases. Students will

improve their communicational skills in order to counsel patients more efficiently and improve adherence to medications. The

undergraduates will acquire knowledge of the innovation of a new drug from a drug candidate, the formation of indications, marketing

authorization, the life cycle of medicines and generics, as well as professional aspects of medication errors and adverse event.

Students can access the slides of the lectures and further reading material on a designated web based interface (e.g. MS Teams and/or

Neptun Meet Street).


- Regular attendance of classes (maximum 25 % of absence is accepted),

- Assignments given in class should be carried out during term-time and,

- Written mid-term and end-of-the term test. Passing the tests is not obligatory; however advisable as you will likely have better

results and a good recommended grade for PPM1.There is a retake opportunity only for the end-of-the term test.

Mid-term exams

End-of-the-term test is at the regular time of lectures.

The test will be on the whole semester’s curriculum. Additional questions can be included in the end-of-the-term test, if the student has

not carried out an assignment during the semester or in case of unsuccessful midterm test.

In case of unsuccessful or missed end-of-the term test, a retake opportunity is granted to make up during the last week of the semester.

The end-of-the term test grade may be accepted as an examination grade, if passed.


Retake opportunity is possible following personal discussion for the end-of-the term test.

Reading material



List of study aids to acquire curriculum (books, notes, other) and all presentations can be downloaded from MS Teams and/or Neptun

MeetStreet.

- Notes


J.L. Bootman, R. J. Townsend, W. F. McGhan (eds.): Principles of Pharmacoeconomics, Harvey Whitney Book Company, 2002.

Robert S. Beardsley, Carole L. Kimberlin, William N. Tindall: Communication Skills in Pharmacy Practice, 6th edition, Wolters

Kluwer, Lipincott Williams & Wilkins, 2012.

Rosemary R. Berardi, Stefanie P. Ferreri et al.: Handbook of Nonpresciption Drugs, 17th edition, American Pharmacists Association, 2012.

John P. Griffin, John Posner, Geoffrey R. Barker: The Textbook of Pharmaceutical Medicine, 7th Edition, 2013.

Paul Rutter: Community Pharmacy - Symptoms, Diagnosis and Treatment. 4th Edition Elsevier 2017.

Lectures

1 Drug authorization process, Patent of drugs 1

Dr. Miseta Ildikó

2 Drug authorization process, Patent of drugs 2

Dr. Miseta Ildikó

3 Variations of authorization processes (orphan drugs, generic, etc.)

Dr. Miseta Ildikó

4 Drug Research and Development

Dr. Vida Róbert György


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5 Nonclinical studies, preclinical development, Design and methodology in clinical trials


6 Clinical trials 1


7 Clinical trials 2


8 The drug supply chain, participants of the drug market 1.

Dr. Fittler András Tamás

9 The drug supply chain, participants of the drug market 2.


10 Prescribing and reimbursement of medicines in Hungary 1.


11 Prescribing and reimbursement of medicines in Hungary 2.


12 Equivalencies of drugs 1

Dr. Miseta Ildikó

13 Equivalencies of drugs 2

Dr. Miseta Ildikó

14 Midterm test


15 Pharmacovigilance 1


16 Pharmacovigilance 2


17 Organisation of Hungarian health system


18 Principles and basic terms of economics


19 Requirements of opening and operation of pharmacies. Regulation of public drug supply.


20 Market mechanisms. Economic actors, sectors of economy.


21 Perfect market and health market 1.


22 Perfect market and health market 2.


23 Social insurance, healthcare systems.

Dr. Bella Richárd

24 Regulation regarding prescribing and dispensing of medicines in Hungary. Limitation of distribution of medicines in the EU.


25 Requirements of opening and operation of pharmacies. Regulation of public drug supply


26 End-of-the term test






Practices

Seminars

1 Basics of communication. Importance of good communication in pharmacy.


2 Steps of good communication 1.

Dr. Miseta Ildikó

3 Steps of good communication 2.

Dr. Miseta Ildikó

4 Written communication, oral presentation.



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5 Introduction - self-care, legal issues.


6 Introduction - patient assessment and consultation.


7 Midterm test


8 Sample presentation, PowerPoint presentation scheme.


9 Nutrition, mineral replacement and vitamins.

Dr. Bella Richárd

10 Dry skin, atopic dermatitis, acne.

Dr. Somogyi-Végh Anna

11 Smoking cessation.


12 Minor burns, wounds.

Dr. Bella Richárd

13 Simulation of a small, pilot clinical study.



Dr. Bella Richárd


Assessment of the student performance is carried out according to a five-grade scale:100-86,1% -excellent (5); 86-77,1% -good (4); 77-

68,1% -satisfactory (3); 68-60,1% -pass (2); and below 60,0% -fail (1) respectively.

Final recommended grade for PPM1 is based upon the completion of the given assignments, self-care and nonprescription

pharmacotherapy module, the mid-term test and the end-of-the term test. There is no practical grade for PPM1.

Participants

Dr. Bella Richárd (IL65ZJ), Dr. Fittler András Tamás (IYR5HQ), Dr. Miseta Ildikó (B743LU), Dr. Somogyi-Végh Anna (CPFSLI)


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OPG-PPA-T PHARMACEUTICAL PATHOLOGY

Course director: DR. LIVIA VIDA, specialist

Department of Pathology [email protected]




Topic

Our course is devoted to interpret the patholgic basis of diseases to pharmacist undergraduates. Our aim is to present the study of the

structural, biochemical, and functional changes in cells, tissues and organs that underlie diseases. By the use of molecular, microand

macromorphologic techniques, pathology attempts to provide diagnosis and a rational basis for clinical care and therapy, placing special

emphasis on pharmacotherapeutic aspects. Pathology serves as the bridge between the basic sciences and clinical studies and is the

scientific foundation for the entirety of the medicine.



Mid-term exams

Students will have two midterm exams (around week 7 and 14). The final grade is calculated as the arithmetic average of the two

midterms' results.


There is no opportunity to make up missed classes.

Reading material



Lecture handouts are provided. Recorded lectures in mp4 format are also available.

- Notes


Robbins Basic Pathology, 10th Edition.

Lectures

1 Disease types in the human body. Necrosis. Acute and chronic inflammation. Oncology basic concepts.

Dr. Vida Livia

2 Disease types in the human body. Thronbosis and embolisation. Pathology of the immune system.

Dr. Vida Livia

3 Cardiovascular diseases I. Heart diseases. Disease of arteries and veins.

Dr. Vida Livia

4 Cardiovascular diseases II. High blood pressure. Valvular diseases. Developmental malformations.

Dr. Vida Livia

5 Diseases of the respiratory system I. Upper and lower airway infections. Asthma. Acute lung injury.

Dr. Vida Livia

6 Diseases of the respiratory system II. COPD. Pneumoconioses. Laryngeal and lung cancer.

Dr. Vida Livia

7 Diseases of the liver and the biliary system. Liver failure. Hepatitides. Cholelithiasis. Pancreatitis. Malignant diseases.

Dr. Vida Livia

8 Diseases of the kidney and the male genitalia. Glomerulonephritides. Pyelonephritides. Kidney stones. Diseases of the testis and

the prostate. Malignant diseases.

Dr. Kaszás Bálint

9 Diseases of the gastrointestinal tract I. Diseases of the oral cavity, the esophagus and the stomach.

Dr. Kaszás Bálint

10 Diseases of the gastrointestinal tract II. Diseases of the small and the large intestine.

Dr. Kaszás Bálint

11 Diseases of the hemopoetic system. Anemias. Hodgkin lymphoma. Non-hodgkin lymphomas. Acute leukaemias.

Dr. Kaszás Bálint

12 Diseases of the endocrine system. Pituitary, thyroid and adrenal gland diseases.

Dr. Kaszás Bálint


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13 Diseases of the central nervous system. Circulatory dysturbances. Dementias. Infections. Demyelinisating and malignant

diseases.

Dr. Kaszás Bálint

14 Diseases of the female genital tract. Breast cancer. Cervical cancer. Endometriosis.

Dr. Kaszás Bálint

Practices

Seminars


Disease types in the human body.

Cardiovascular diseases.

Diseases of the respiratory system.

Diseases of the liver and the biliary system.

Diseases of the kidney and the male genitalia.

Diseases of the gastrointestinal tract.

Diseases of the hemopoetic system.

Diseases of the endocrine system.

Diseases of the central nervous system.

Diseases of the female genital tract.

Participants


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OPG-R3E-T PHARMACEUTICAL CHEMISTRY 3 - THEORY

Course director: DR. ZSUZSANNA ROZMER, assistant professor

Department of Pharmaceutical Chemistry [email protected]




Topic

Introduction to molecular aspect, structure-activity relationship and pharmacopoeal qualification of selected group of active

pharmaceutical ingredients. Basic principles and application of the analytical methods most frequently used in the pharmacopoeal

qualifications.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation is both the lectures and the

practices is obligatory. Maximum three absences can be accepted both from lectures and practices. Students have to write two midterm

tests (week 7. and 12.) from the topics of the theory and the practice. One of the test result should be above 60%, the average of the tests

should be above 50%. One re-take test is allowed at the 14th weak of the semester. Students have to write at least four mini-tests on the

practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is

evaluated by a practical grade. Satisfactory (2) evaluation is the minimum requirement of acknowledgement of the semester.

Mid-term exams

Students have to write two midterm tests (week 7. and 12.) from the topics of the theory and the practice. One of the test result should be

above 60%, the average of the tests should be above 50%. One re-take test is allowed at the 14th weak of the semester. Students have to

write at least four mini-tests on the practices. The average of the results must be at least 50%. The practical work (results of the written

tests and the experimental work) is evaluated by a practical grade. Satisfactory (2) evaluation is the minimum requirement of

acknowledgement of the semester.



Reading material


D.A. Williams, T.L. Lemke (eds.): Foye's Principles of Medicinal Chemistry, 7th edition, Lippincott Williams & Wilkins,

Philadelphia, 2013


Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry 1. Laboratory Experiments and Commentary, electronic

educational material, PTE 2014

- Notes


European Pharmacopoeia, EDQM Publication

Lecture notes.

Lectures

1 Application of CD and ORD spectroscopy in pharmaceutical analysis.

Dr. Perjési Pál

2 Application of UV-Vis spectroscopy in pharmaceutical analysis

Dr. Perjési Pál

3 Application of UV-Vis spectroscopy in pharmaceutical analysis.

Dr. Perjési Pál

4 Application of thermoanalytic methods in pharmaceutical analysis.

Dr. Kulcsár Győző Kornél

5 Application of fluorimetry in pharmaceutical analysis.

Dr. Perjési Pál

6 Application of fluorimetry in pharmaceutical analysis.

Dr. Perjési Pál

7 Application of atomic absorption spectrometry and flame photometry in pharmaceutical analysis.


8 Application of IR spectroscopy in pharmaceutical analysis.

Dr. Lóránd Tamás


21

9 Application of IR spectroscopy in pharmaceutical analysis.

Dr. Lóránd Tamás

10 Biological drugs I.

Dr. Rozmer Zsuzsanna

11 Application of NMR spectroscopy in pharmaceutical analysis.

Dr. Perjési Pál

12 Application of NMR spectroscopy in pharmaceutical analysis.

Dr. Perjési Pál

13 Biological drugs II.


14 Application of mass spectrometry in pharmaceutical analysis.


15 Application of mass spectrometry in pharmaceutical analysis.


16 Antiallergic antihistamines. Drugs for rheumatic gout I.


17 Application of electroanalytical methods in pharmaceutical analysis.

Dr. Perjési Pál

18 Application of electroanalytical methods in pharmaceutical analysis.

Dr. Perjési Pál

19 Antiallegic antihistamines. Drugs for rheumatic gout II.


20 Agents of cardiac failure.

Dr. Perjési Pál

21 Agents of cardiac failure.

Dr. Perjési Pál

22 Antianginal drugs.


23 Agents of antiarythmic agents.

Dr. Almási Attila

24 Agents of antiarythmic agents.

Dr. Almási Attila

25 Antithrombotics, Thrombolytics, Coagulants I.


26 Antihipertensive agents.

Dr. Almási Attila

27 Antihipertensive agents.

Dr. Almási Attila

28 Antithrombotics, Thrombolytics, Coagulants II.


29 Antihiperlidemic agents.


30 Antihiperlidemic agents.


31 Drugs affecting thyroid functions.

Dr. Almási Attila

32 Diuretics.

Dr. Almási Attila

33 Diuretics.

Dr. Almási Attila

34 Adrenocorticoids I.

Dr. Perjési Pál

35 Drugs affecting calcium homeostatis.


36 Drugs affecting calcium homeostatis.


37 Adrenocorticoids II.

Dr. Perjési Pál


22

38 Insulin and oral hypoglycemic drugs.

Dr. Almási Attila

39 Insulin and oral hypoglycemic drugs.

Dr. Almási Attila

40 Estrogens, Androgens, Progestins I.

Dr. Perjési Pál

41 Estrogens, Androgens, Progestins II.

Dr. Perjési Pál

42 Estrogens, Androgens, Progestins II.

Dr. Perjési Pál

Practices

Seminars


Written exam covering the topics of the lectures and the laboratory practices. The result of the written exam must be above 60%. The

final grade is based on results of the midterm tests and the written exam. Maximum contribution of the results of the midterm tests

to the total score of the written exam is 25%. Participation on the first exam is compulsory.

Participants


23

OPG-R3G-T PHARMACEUTICAL CHEMISTRY 3 - PRACTICE






Topic

Introduction to the most important instrumental analytical methods and their applications to pharmacopoeal qualification of active

pharmaceutical ingredients and excipients in pharamaceutical formulations.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the practices is obligatory.

Maximum three absences can be accepted. Students have to write at least four short tests on the practices. The average of the results must

be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practice grade.

Mid-term exams

Students have to write at least four short tests on the practices. The average of the results must be at least 50%. The practical work (results

of the written tests and the experimental work) is evaluated by a practice grade.



Reading material



Philadelphia, 2013


Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry 1. Laboratory Experiments and Commentary, electronic


- Notes

Pharmaceutical Chemistry Practice 1, laboratory manual, University of Pécs, 2015


European Pharmacopoeia, EDQM Publication

Lecture notes.

Lectures

Practices

1 Laboratory safety and accident protection. Preliminary testing and classification of inorganic and organic compounds I.

Identification of 10 inorganic and organic substances I.







5 Preliminary testing and classification of inorganic and organic compounds II. Identification of 10 inorganic and organic

substances II.


substances II.


substances II.


substances II.

9 Principles of validation of analytical methods. (Seminars)





24

13 Validation of a titrimetric methods. Comparison of different methods, Determination of sodium hydrogen carbonate according

to the Ph. Hg. VII. and the Ph. Hg. VIII.







17 Spectrophotometry I. The Lambert-Beer's law. Determination of specific absorbance. Spectrophotometric determination of

coffein, aminophenazone and paracetamol in powder mixtures.







21 Spectrophotometry II. Determination of salicylic acid and acetylsalicylic acid in mixtures by spectrophotometric and alkalimetric

methods.


methods.


methods.


methods.

25 Application of fluometric methods. Application of NMR in pharmaceutical analysis. Principles of evaluation of NMR spectra.

Evaluation of 1H and 13C NMR spectra of selected drug substances. (Seminar)







29 Application of IR in pharmaceutical analysis. Principles of evaluation of IR spectra. Evaluation of IR spectra of selected drug

substances. (Seminar) Application of mass spectrometry methods.







33 Application of electroanalytical methods in pharmaceutical analysis. (Seminar)




37 Potentiometry I. Principles of potentiometry. Direct potentiometry and potentiometric titration. Determination of a strong and a

weak acid in mixtures.







41 Potentiometry II. Electrodes used in potentiometry. Definition and importance of the pKa value. Determination of the pKa by

direct potentiometric titration.







45 Spectrophotometry III. Determination of the pKa of a weak acid and a weak base by spectrophotometry.




25


49 Pharmacopoeial analysis of steroidal hormons.




53 Basics of stereochemistry. Stereochemistry of steroids and derivatives.




Seminars


The practical work (results of the written tests and the experimental work) is evaluated by a practice grade.

Participants

Dr. Almási Attila (KJ5MBZ), Dr. Rozmer Zsuzsanna (IIDYH7)


26

OPO-KE1-T PUBLIC HEALTH 1

Course director: DR. ISTVÁN ZOLTÁN KISS, professor

Department of Public Health Medicine [email protected]

2 credit ▪ semester exam ▪ Med.-biol. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 7



Topic

Public Health represents the preventive side of medicine. The subject deals with primary, secondary and tertiary prevention of the most

challenging diseases of public health.

The aims are to exam the process of disease development and demonstrate the possibilities of prevention on individual and community

levels.


Mid-term exams


Reading material


Edit Paulik: Public Health and Preventive Medicine, Medicina Publishing House, Budapest 2013.


Educational material uploaded on Neptun.

- Notes


Lectures

1 Global overview of health status. Definition of health and disease. Health determinants.

Dr. Kiss István Zoltán

2 Global overview of health status. Definition of health and disease. Health determinants.


3 History of public health. Scope of preventive medicine. Basics of disease prevention. Levels of prevention.


4 History of public health. Scope of preventive medicine. Basics of disease prevention. Levels of prevention.


5 Demography.

Dr. Horváth-Sarródi Andrea

6 Demography.


7 Basics of epidemiology, epidemiological indicators.

Dr. Szabó István

8 Basics of epidemiology, epidemiological indicators.

Dr. Szabó István

9 Epidemiological studies.

Dr. Szabó István

10 Epidemiological studies.

Dr. Szabó István

11 Nutritional epidemiology 1.: Basics of nutrition. Healthy nutrition, dietary recommendations. Nutrition related diseases.

Dr. Szabó István

12 Nutritional epidemiology 1.: Basics of nutrition. Healthy nutrition, dietary recommendations. Nutrition related diseases.

Dr. Szabó István

13 Nutritional epidemiology 2.: Nutritional habits, fad diets.


14 Nutritional epidemiology 2.: Nutritional habits, fad diets.


15 Nutritional epidemiology 3. Role of diet in the development of major chronic non infectious diseases.



27

16 Nutritional epidemiology 3. Role of diet in the development of major chronic non infectious diseases.


17 Screening.

Dr. Szabó István

18 Screening.

Dr. Szabó István

19 Epidemiology of cardiovascular diseases.


20 Epidemiology of cardiovascular diseases.


21 Cancer epidemiology.


22 Cancer epidemiology.


23 Epidemiology of diabetes and obesity. Epidemiology of osteoporosis.

Dr. Németh Katalin

24 Epidemiology of diabetes and obesity. Epidemiology of osteoporosis.

Dr. Németh Katalin

25 Epidemiology of respiratory and gastrointestinal diseases.

Dr. Németh Katalin

26 Epidemiology of respiratory and gastrointestinal diseases.

Dr. Németh Katalin

27 Epidemiology of suicide, epidemiology of mental disorders.


28 Epidemiology of suicide, epidemiology of mental disorders.


Practices

Seminars


Questions of choice Public Health 1.

1. Global overview of health status.

2. Definition of health and disease. Health determinants.

3. History of public health. Scope of preventive medicine.

4. Basics of disease prevention. Levels of prevention.

5. Demography.

6. Basics of epidemiology.

7. Epidemiological indicators.

8. Epidemiological studies.

9. Basics of nutrition. Nutritional habits.

10. Nutrition related diseases.

11. Healthy nutrition, dietary recommendations.

12. Role of diet in the development of major chronic non infectious diseases.

13. Screening.

14. Epidemiology of cardiovascular diseases.

15. Cancer epidemiology.

16. Epidemiology of obesity.

17. Epidemiology of diabetes.

18. Epidemiology of osteoporosis.

19. Epidemiology of respiratory diseases.

20. Epidemiology of gastrointestinal diseases.

21. Epidemiology of suicide, epidemiology of mental disorders.

Participants


28

OPG-C4E-T PHARMACEUTICAL TECHNOLOGY 4 - THEORY



2 credit ▪ final exam ▪ Pharm. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 8



Topic

In this semester solid dosage forms, theoretical introduction of granulation, tabletting and tablet coating is discussed. Quality control of

prepared dosage forms are also carried out such as disintegration, dissolution, tablet hardness test, etc. Aspects and work in industrial

pharmacy is also presented during this semester.


Code of Studies and Regulations

Mid-term exams

Students have to write three assessments during the semester and they have to reach 60 % after average calculation. After two assessments

if students reach average 60 % taking into account both tests, writing the third assesment it not compulsory. The third assessments (which

is considered as the 1st retake) has to be above 60,1 %. If the student fails on the 3rd assessment, there is still chance for the 2nd retake,

where student has to reach 60,1% for the acceptance of the semester. In case of confirmed absence from the assessment, re-take chance

is sossible for the student. Missing the re-take results 0 % assessment.



Reading material



Lecture slides

- Notes







www.gytk.pte.hu




Lectures

1 Drug Delivery Systems 1

Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd






Dr. Kása Péter


Dr. Kása Péter




29

9 Written test

Dr. Pál Szilárd

10 Written test

Dr. Pál Szilárd

11 Multiparticulate systems 1 (microcapsules, micropellets)

Dr. Pál Szilárd

12 Multiparticulate systems 1 (microcapsules, micropellets)

Dr. Pál Szilárd

13 Multiparticulate systems 2 (molecular dispersion, liposomes, dendrimers, kohleats, kvantum dots, nanotubes)

Dr. Pál Szilárd

14 Multiparticulate systems 2 (molecular dispersion, liposomes, dendrimers, kohleats, kvantum dots, nanotubes)

Dr. Pál Szilárd

15 Development of pharmaceutical dosage forms 1

Dr. Kása Péter


Dr. Kása Péter


Dr. Pál Szilárd


Dr. Pál Szilárd

19 Written test

Dr. Pál Szilárd

20 Written test

Dr. Pál Szilárd

21 Stability of preparations

Dr. Pál Szilárd

22 Stability of preparations

Dr. Pál Szilárd

23 Wrapping of pharmaceutical preparations

Dr. Pál Szilárd

24 Wrapping of pharmaceutical preparations

Dr. Pál Szilárd

25 Quality Assurance, GMP

Ámanné Dr. Takácsi-Nagy Anna

26 Quality Assurance, GMP

Ámanné Dr. Takácsi-Nagy Anna

27 Official approval, validation, reproducibility, process control

Dr. Pál Szilárd

28 Written test

Dr. Pál Szilárd

Practices

Seminars


After the semester the exam is a complex exam from all Pharmaceutical Technology 1-2-3-4 courses evaluated by a five-grade system.

Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute.The end-semester exam

will be evaluated by a five-grade system.

Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute.

At the end of semester, students take oral exam. Chance "B" and "C"are also oral exams, which is preceded by the "Minimum Test"

(MT). To write the MT, students have at most 30 minutes, and will be evaluated percent rating. Those students, who achieve less

than 60% in MT, unsatisfactory grade will be assessed and cannot pass them to the oral part of the exam.

Oral part includes two topics. In the case of any part done with insufficient knowledge, will result in assessment of the exam to

unsatisfactory grade.

In addition to the exam topics, part of the exam is answering questions that aim at assessing the general knowledge of the student.

Participants


30

OPG-C4G-T PHARMACEUTICAL TECHNOLOGY 4 - PRACTICE



4 credit ▪ midsemester grade ▪ Pharm. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 8



Topic

In this semester solid dosage forms, theoretical introduction of granulation, tabletting and tablet coating is discussed. Quality control of

prepared dosage forms are also carried out such as disintegration, dissolution, tablet hardness test, etc. Aspects and work in industrial

pharmacy is also presented during this semester.


1. Accepted preparations made on practices.

2. Accepted work reports.

3. Accepted practical and theoretical assessments.

4. At the beginning of all practice classes students write short tests of different types (dose checking, synonim names and latin

expressions, calculations). Semester only can be accepted if students reach at least 50% from each short test type.

Evaluation of the practices is according to the semester work (practice work, assessments, work reports) by practice grade.

5. During the 2nd part of the semester students have to make 2 preparations for grade on each practice. After taking into account average

of all grades students have to reach grade 2,50 for the acceptance of the semester.

Mid-term exams

During the 2nd part of the semester students have to make 2 preparations for grade on each practice. After taking into account average

of all grades students have to reach grade 2,50 for the acceptance of the semester.



All missed or failed preparations manufactured on the practice should be made up on supplementary practices!

Reading material



- Notes







www.gytk.pte.hu




Lectures

Practices

1 General instructions, rules and regulations on practices, solutions, nasal drops, ear drops




5 Emulsions, suspensions







31

9 Eye oinments, eyes drops, tea mixtures, decoctum, infusum




13 Ointments/creams/pastes/gels




17 Vaginal, rectal suppositories




21 Powders, pills, hard gelatin capsules




25 Personal assessment 1.




























53 End-semester assessment of practice




Seminars


Website of the Institute.

Participants

Dr. Ferenczi Krisztina (I8U2DJ), Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (FYF5E9), Kopcsányi Márton (D3S7AX)


32

OPG-D2E-T PHARMACODYNAMICS 2 - THEORY



2 credit ▪ semester exam ▪ Pharm. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 8



Topic

The aim of the course is to provide the students with the pharmacological knowledge required for their future work in the pharmacy.

Important topics are pharmacology of the blood, pharmacology of histamine, serotonin and eicosanoids, pharmacology of the respiratory

tract and the gastrointestinal tract, pharmacology of the central nervous system. Drug abuse and dependence as well as non-steroidal anti-

inflammatory drugs will also be discussed.



Mid-term exams

There is no midterm eaxm/test.



Reading material




- Notes




Lectures

1 Drugs used for treating hyperlipoproteinemias I

Dr. Poór Miklós

2 Drugs used for treating hyperlipoproteinemias II

Dr. Poór Miklós

3 Drugs affecting hemostasis I

Dr. Poór Miklós

4 Drugs affecting hemostasis II

Dr. Poór Miklós

5 Drugs affecting hemostasis III

Dr. Poór Miklós

6 Drugs affecting hemostasis IV

Dr. Poór Miklós

7 Drugs affecting hematopoiesis I


8 Drugs affecting hematopoiesis II


9 Introduction to the pharmacology of the central nervous system I

Dr. Barthó Loránd

10 Introduction to the pharmacology of the central nervous system II

Dr. Barthó Loránd

11 Antianxiety and hypnotic drugs I

Dr. Poór Miklós

12 Antianxiety and hypnotic drugs II

Dr. Poór Miklós

13 Pharmacology and toxicology of alcohols I

Dr. Poór Miklós


33

14 Pharmacology and toxicology of alcohols II

Dr. Poór Miklós

15 Antipsychotic drugs I


16 Antipsychotic drugs II


17 Antidepressants I

Sánticsné Dr. Pintér Erika

18 Antidepressants II


19 Antiepileptic drugs I


20 Antiepileptic drugs II. Centrally-acting muscle relaxants


21 Opioid analgesic drugs I


22 Opioid analgesic drugs II


23 Opioid analgesic drugs III


24 Opioid analgesic drugs IV


25 Non-steroidal antiinflammatory drugs I


26 Non-steroidal antiinflammatory drugs II


27 Non-steroidal antiinflammatory drugs III


28 Adjuvant analgesics. Drug treatment of gout


Practices

Seminars


Reqirements: the exams are oral, the required topics are dealt with during the semester lectures and practical classes. The criterion of

admission to the exam is the successful completion of the pharmacodynamics 2 practice course carried out in paralell (at least

satisfactory midsemester grade).

Exam questions:

1. Antianxiety and hypnotic drugs

2. Alcohols: pharmacology, toxicology

3. Antipsychotic drugs

4. Antidepressants

5. Central nervous system stimulants. Nootropic drugs

6. Drug treatment of neurodegenerative disorders

7. General anesthetics

8. Antiepileptic drugs

9. Opioid analgesic drugs: morphine and codeine

10. Opioid analgesic drugs: semisynthetic, synthetic opioids, opioid antagonists

11. Non-steroidal antiinflammatory drugs: aspirin, paracetamol

12. Non-steroidal antiinflammatory drugs: drugs other than aspirin or paracetamol

13. Adjuvant analgesics. Drugs used to treat gout. Centrally-acting muscle relaxants

14. Basic terms of drug abuse. Psychedelics, nicotine, cannabis, inhalants

15. Drugs used to treat hyperlipoproteinaemias

16. Anticoagulants, antiplatelet drugs

17. Fibrinolytics, antifibrinolytics, hemostatic agents

18. Drugs affecting hematopoiesis

19. Histamine, H1 and H2 receptor antagonists

20. Serotonin, serotonin receptor agonists and antagonists


34

21. Pharmacology of eicosanoids. Drugs acting on the smooth muscle: smooth muscle relaxants, pharmacology of the uterine muscle

22. Drugs used in bronchial asthma

23. Drugs used in allergic rhinitis. Antitussive, expectorant and mucolytic agents

24. Drugs used in the treatment of peptic ulcer

25. Emetics, antiemetics and prokinetic drugs. Digestives, drugs used in cholelithiasis

26. Laxatives, antidiarrheal agents, drug treatment of inflammatory bowel diseases

27. Harmful effects of drugs and their mechanisms

In addition to the exam topics, an important part of the exam is answering questions that aim at assessing the general knowledge of the

student.

Participants


35

OPG-D2G-T PHARMACODYNAMICS 2 - PRACTICE






Topic

The aim of the course is to provide the students with the pharmacological knowledge required for their future work in the pharmacy.

Important topics are pharmacology of histamine, serotonin and eicosanoids, pharmacology of the respiratory tract and the gastrointestinal

tract, pharmacology of the central nervous system.



Mid-term exams

The students receive a practice grade based on their performance during the semester. The grade will be registered in the Neptun as a

midsemester grade. The grade must be at least satisfactory as a prerequisite for taking the semester exam. Around the 11th week of the

semester, a written test is the base of the practice grade. The test covers the subjects of practice classes of the first 10 weeks of the

semester and 50% of the available points must be reached for acceptance of the semester. Should someone fail or want to improve, they

can do it one time before the end of the semester. On a final failure (that is, after the improvement attempt still below 50%), the student

cannot have semester accepted.



Reading material




- Notes




Lectures

Practices

1 Pharmacology of histamine and histamine receptor antagonists I.


2 Pharmacology of histamine and histamine receptor antagonists II.


3 Serotonine and 5-HT receptor agonists


4 5-HT receptor antagonists. Drug therapy of migraine


5 Pharmacology of eicosanoids


6 Drugs acting on smooth muscles, including uterine muscle


7 Pharmacology of the respiratory tract I.


8 Pharmacology of the respiratory tract II.


9 Pharmacology of the respiratory tract III.


10 Pharmacology of the respiratory tract IV.



36

11 Pharmacology of the gastrointestinal tract I.


12 Pharmacology of the gastrointestinal tract II.


13 Pharmacology of the gastrointestinal tract III.


14 Pharmacology of the gastrointestinal tract IV.


15 Pharmacology of the gastrointestinal tract V.


16 Pharmacology of the gastrointestinal tract VI.


17 General anesthetics I.


18 General anesthetics II.


19 Drug treatment of the neurodegenerative disorders I.


20 Drug treatment of the neurodegenerative disorders II.


21 Central nervous system stimulants I.


22 Central nervous system stimulants II. Nootropic agents


23 Drug abuse I.


24 Drug abuse II.


25 Drug abuse III.


26 Drug abuse IV.


27 Harmful effects of drugs and their mechanisms I.


28 Harmful effects of drugs and their mechanisms II.


Seminars


1. Histamine, H1 and H2 receptor antagonists

2. Serotonin, serotonin receptor agonists and antagonists

3. Pharmacology of eicosanoids. Drugs acting on the smooth muscle: smooth muscle relaxants, pharmacology of the uterine muscle

4. Drugs used in bronchial asthma

5. Drugs used in allergic rhinitis. Antitussive, expectorant and mucolytic agents

6. Drugs used in the treatment of peptic ulcer

7. Emetics, antiemetics and prokinetic drugs. Digestives, drugs used in cholelithiasis

8. Laxatives, antidiarrheal agents, drug treatment of inflammatory bowel diseases

9. Drug treatment of neurodegenerative disorders

10. General anesthetics

Participants

Dr. Börzsei Rita Judit (WYZW6G), Dr. Faisal Anna Zelma (KVG5NA), Dr. Fliszár-Nyúl Eszter (TUOYWS), Dr. Mohos Violetta

Karolin (K9WTSC), Dr. Pethő Gábor István (F2YVEE), Hartnerné Dr. Pohóczky Krisztina (OX02SO), Sánticsné Dr. Pintér Erika

(A66I29)


37

OPG-GBI-T PHARMACEUTICAL BIOTECHNOLOGY

Course director: DR. JUDIT ERZSÉBET PONGRÁCZ, professor

Department of Pharmaceutical Biotechnology [email protected]




Topic

The aim of the course is to provide basic understanding of modern, biotechnology based drug development. The course provides insight

into drug development and production using the methodological and technical arsenal of biotechnology in the pharmaceutical industry.



Mid-term exams

On the 7th week, written test


None

Reading material



Lecture ppt

- Notes

Pharmaceutical Biotechnology


Lectures

1 Introduction. Significance of biotechnology in pharmaceutical sciences


2 Drug development - differences in small molecular drug and biotechnological drug development


3 Biotechnology in drug development research


4 Recombinant DNA technology in drug development I.


5 Recombinant DNA technology in drug development II.


6 Plant biotechnology for production therapy of small molecular drugs I.


7 Plant biotechnology for production therapy of small molecular drugs II.


8 Human protein based pharmaceutical products I.


9 Human protein based pharmaceutical products II.


10 Antibody based pharmaceutical products - variations in monoclonal antibodies


11 The latest methodology of producing monoclonal antibodies I.


12 The latest methodology of producing monoclonal antibodies II.


13 Hematopoietic growth factors and coagulation factors


14 Hematopoietic growth factors and coagulation factors - when do recombinant DNA technology based production work effectively

for factor production



38

15 Cytokines and interferons - produced by recombinant technology


16 Hormones and enzymes - importance of expression vectors


17 Complex biotechnology - engineered viral based systems I.


18 Complex biotechnology - engineered viral based systems II.


19 Vaccine production - subunit vaccines


20 Vaccine production - adenovirus based vaccines


21 Vaccine production - mRNA based vaccines


22 Anti-tumor vaccines


23 Advanced therapeutic medicinal products - possibilities and methodologies of gene therapy


24 Advanced therapeutic medicinal products - viral delivery systems in gene therapy II.


25 Advanced therapeutic medicinal products - cell therapy - is it pharmacy? III.


26 Drug delivery methodology - testing with biotechnological methodology


27 Personalized therapy and biotechnology I.


28 Personalized therapy and biotechnology II.


Practices

Seminars


Meetstreet

Participants


39

OPG-KL1-T CLINICAL STUDIES 1

Course director: DR. RÓBERT GYÖRGY VIDA, assistant professor





Topic

The aim of the course is to introduce the most important clinical fields to the pharmacy students. The knowledge related to the most

common disorders, and their non-pharmacological and pharmacological therapies, and also the therapeutic algorithms and regimens are

crucial for the pharmacists nowadays in every therapeutic field from the community pharmacy, hospital and clinical pharmacy to the

clinical research pharmacy as well. The course is closely linked to the pharmacotherapy studies and other clinical oriented subjects in the

9th semester (e.g.: clinical laboratory studies, clinical pharmacy and pharmacotherapy management, forensic pathology and toxicology,

toxicology).



Mid-term exams

There are no midterm and end-of-the term tests.


The absences should be discussed with the course director.

Reading material



- Notes


Karen J. Tietze. Clinical Skills for Pharmacists. A Patient-Focused Approach, 3rd edition, 2004.

Roger Walker, Cate Whittlesea (eds.): Clinical Pharmacy and Therapeutics, 5th edition, Churchill Livingstone Elsevier, 2012.

Christopher A Langley and Dawn Belcher: Applied Pharmaceutical Practice. Second Edition. Pharmaceutical Press. 2012.

Sally-Anne Francis, Felicity Smith, John Malkinson, Andrew Constanti and Kevin Taylor. Integrated Pharmacy Case Studies.

Pharmaceutical Press, 2015. First edition.

Stephen A. McClave, Denise Baird Schwatrz, Debra S. Kovacevich, Sarah J. Miller. The A. S. P. E. N. Adult Nutrition Support Core

Curriculum, 2nd Edition, 2012.



Lectures

1 Basic principles of pharmacotherapy in internal medicine 1.

Dr. Cziráki Attila

2 Basic principles of pharmacotherapy in internal medicine 2.

Dr. Cziráki Attila

3 Basic principles of pharmacotherapy in cardiology 1.

Dr. Magyar Klára

4 Basic principles of pharmacotherapy in cardiology 2.

Dr. Magyar Klára

5 Basic principles of pharmacotherapy in gastroenterology 1.

Dr. Mohás Márton

6 Basic principles of pharmacotherapy in gastroenterology 2.

Dr. Mohás Márton

7 Basic principles of pharmacotherapy in hepatology 1.

Dr. Pár Alajos

8 Basic principles of pharmacotherapy in hepatology 2.

Dr. Pár Alajos

9 Basic principles of diseases and therapy in nephrology 1.

Dr. Sélley Eszter


40

10 Basic principles of diseases and therapy in nephrology 2.

Dr. Sélley Eszter

11 Basic principles of pharmacotherapy in metabolic disorders, diabetes and hypertension 1.

Dr. Kun Szilárd János

12 Basic principles of pharmacotherapy in metabolic disorders, diabetes and hypertension 2.

Dr. Kun Szilárd János

13 Basic principles of pharmacotherapy in hematology 1.

Dr. Kosztolányi Szabolcs

14 Basic principles of pharmacotherapy in hematology 2.

Dr. Kosztolányi Szabolcs

15 Basic principles of diseases and pharmacotherapy in pulmonology 1.

Dr. Ruzsics István

16 Basic principles of diseases and pharmacotherapy in pulmonology 2.

Dr. Ruzsics István

17 Basic principles of pharmacotherapy in endocrinology 1.

Dr. Nemes Orsolya

18 Basic principles of pharmacotherapy in endocrinology 2.

Dr. Nemes Orsolya

19 Basic principles of pharmacotherapy in infectology 1.

Dr. Péterfi Zoltán

20 Basic principles of pharmacotherapy in infectology 2.

Dr. Péterfi Zoltán

21 The basics of liver surgery

Dr. Papp András

22 The basics of esophageal and stomach surgery 1.

Dr. Papp András

23 The basics of esophageal and stomach surgery 2.

Dr. Papp András

24 The basics of transplantation surgery 1.

Dr. Varga Ádám

25 The basics of transplantation surgery 2.

Dr. Varga Ádám

26 The basics of coloproctology surgery

Dr. Baracs József

27 The basics of pancreas surgery

Dr. Kelemen Dezső Tamás

28 The basics of thoracic surgery

Dr. Jakab László

Practices

Seminars


Written exams are based on the lectures.

There will be 50 single choice question in the test. Assessment of the student performance is carried out according to a five-grade scale:

100-86,1% - excellent (5); 86-77,1% - good (4); 77-68,1% - satisfactory (3); 68-60,1% - pass (2); and below 60,0% - fail (1) respectively.

Participants


41

OPG-R4E-T PHARMACEUTICAL CHEMISTRY 4 - THEORY



2 credit ▪ final exam ▪ Pharm. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 8



Topic

Introduction of molecular aspects and structure activity relationship of selected groups of active pharmaceutical ingredients. Basic

principles and application of the separation techniques most frequently used in the pharmacopoeal qualifications.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation is both the lectures and the

practices is obligatory. Maximum three absences can be accepted both from lectures and practices. Students have to write two midterm

tests (week 7. and 12.) from the topics of the theory and the practice. One of the test result should be at least 60%, and the average of the

test result should be at least 50%. One re-take test is allowed at the 14th weak of the semester.

Mid-term exams

Students have to write two midterm tests (week 7. and 12.) from the topics of the theory and the practice. One of the test result should be

at least 60%, and the average of the test result should be at least 50%. One re-take test is allowed at the 14th weak of the semester.



Reading material



Philadelphia, 2013


Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry 1. Laboratory Experiments and Commentary, Electronic


- Notes


European Pharmacopoeia. EDQM Publication

Lecture notes.

Lectures

1 Stability of drugs.

Dr. Kuzma Mónika

2 Stability of drugs.

Dr. Kuzma Mónika

3 Introduction to separation techniques.

Dr. Perjési Pál

4 Introduction to separation techniques.

Dr. Perjési Pál

5 Application of TLC in pharmaceutical analysis.

Dr. Perjési Pál

6 Application of TLC in pharmaceutical analysis.

Dr. Perjési Pál

7 Application of GC in pharmaceutical analysis.


8 Application of GC in pharmaceutical analysis.


9 Application of HPLC in pharmaceutical analysis.


10 Application of HPLC in pharmaceutical analysis.



42

11 Application of gel chromatography in pharmaceutical analysis.

Dr. Perjési Pál

12 Application of affinity chromatography in pharmaceutical analysis.

Dr. Perjési Pál

13 Vitamins.

Dr. Almási Attila

14 Vitamins.

Dr. Almási Attila

15 Antifungal drugs. Antiparasitic agents.

Dr. Lóránd Tamás

16 Antifungal drugs. Antiparasitic agents.

Dr. Lóránd Tamás

17 Antimicrobial agents.

Dr. Lóránd Tamás

18 Antimicrobial agents.

Dr. Lóránd Tamás

19 Antibiotics I.

Dr. Lóránd Tamás

20 Antibiotics I.

Dr. Lóránd Tamás

21 Antibiotics II.

Dr. Lóránd Tamás

22 Antibiotics II.

Dr. Lóránd Tamás

23 Anticancer agents.


24 Anticancer agents.


25 Antiviral agents.


26 Antiviral agents.


27 Drug research and drug development.

Dr. Perjési Pál

28 Drug research and drug development.

Dr. Perjési Pál

Practices

Seminars


Oral exam covering the topics of Pharmaceutical Chemistry I-IV. Before the exam each student should have a Minimum Requirement

Test of which result should be at least 80%. Further details: www.gytk.pte.hu

Participants


43

OPG-R4G-T PHARMACEUTICAL CHEMISTRY 4 - PRACTICE






Topic

Introduction to quality control of complex pharmaceutical preparations. Application of instrumental methods in pharmacopoeal quality

control of pharmaceutical preparations.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the practices is obligatory.

Maximum three absences can be accepted. Students have to write at least four short tests on the practices. The average of the results must

be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practice grade.

Mid-term exams

Students have to write at least four short tests on the practices. The average of the results must be at least 50%. The practical work (results

of the written tests and the experimental work) is evaluated by a practice grade.



Reading material



Philadelphia, 2013.


Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry 1. Laboratory Experiments and Commentary, Electronic

educational material, PTE 2014.

- Notes

Pharmaceutical Chemistry Practice 2, Laboratory manual, University of Pécs, 2015.


European Pharmacopoeia. EDQM Publication.

Lecture notes.

Lectures

Practices

1 Stability tests. Analysis of degradation of acetylsalicylic acid.




5 Sample preparation. Extaction techniques. Liquid-liquid extraction of salycilic acid.




9 Bases of chromatographic separations I. Detection of methanol in ethanol by TLC method. Separation of albumine and sodium

chloride by gel chromatographic method.







13 Bases of chromatographic separations II. Application of gas chromatography in the analysis of pharmaceutical substances.





44

17 Bases of chromatographic separations III. Application of the high performance liquid chromatography in the analysis of

pharmaceutical substances.







21 Vitamines. Detremination of cyanocobalaminum by UV-Vis and HPLC methods.




25 Identification of multi-component drug mixtures I. General principles. Sample preparation. Determination of bases in drug

mixtures I. Pulvis antispasticus.







29 Identification of multi-component drug mixtures II. Determination of bases in drug mixtures II. Pulvis antidoloricus. Pulvis

astmaliticus. Pulvis codacetini. Application of HPLC.







33 Identification of multi-component drug mixtures III. Determination of bases in drug mixtures III. Pulvis cholagogus, Unguentum

haemorrhoidale, Suppositorium analgeticum.







37 Identification of multi-component drug mixtures IV. Determination of acids in drug mixtures I. Spiritus iodosalicylatus, Spiritus

salicylatus cum resorcino.







41 Identification of multi-component drug mixtures V. Determination of acids in drug mixtures II. Pulvis chinacisalis c. vitamino

C, Pulvis somniferens.







45 Drug metabolism (seminary).




49 In vitro and in vivo methods in the drug metabolism studies. Acetylsalicylic acid, 4-nitrophenol.





45

53 Chemical and structural classification of functional groups and heterocycles. (seminary).




Seminars


N/A

Participants

Dr. Almási Attila (KJ5MBZ), Dr. Rozmer Zsuzsanna (IIDYH7)


46

OPG-TXA-T TOXICOLOGY

Course director: DR. MIKLÓS POÓR, assistant professor





Topic

Toxicology as a subject deals with the toxic (including teratogenic and carcinogenic) effects of drugs and xenobiotics (metals, solvents,

toxic gases, pesticides, mushroom- and plant-derived toxins, etc.) caused by overdose or excessive exposure. It describes the general

aspects of toxicology, the mechanisms of toxicity (including the major influencing factors), the harmful effects and the corresponding

symptoms, the diagnostics of the adverse health effects, as well as their prevention and treatment. In addition, toxicity testing and risk

assessment of chemicals are also shortly discussed.



Mid-term exams

Students are required to take two mid-semester written tests, which are scheduled for weeks 7 and 14, approximately. These tests will

contain multiple choice and short essay type questions. The average score of these two mid-semester tests (%) will be evaluated. We will

offer a final grade for those reaching a mid-term result of at least 70%. On the other hand, those not achieve the 50% limit in the mid-

term tests will get two extra topics during their oral exam.


Missed classes cannot be made up.

Reading material



Slides of each lecture will be available for the students on Neptun Meet Street.

- Notes


Casarett & Doull's Toxicology, 9th edition, McGraw-Hill, 2019.

Lectures

1 Basic principles of toxicology.

Dr. Poór Miklós

2 Human intoxications: Occurrence and classification. Causes of poisoning-related death.

Dr. Poór Miklós

3 Management of the poisoned patient I. - Emergency care, diagnostics, antidotes.

Dr. Poór Miklós

4 Management of the poisoned patient II. - Decontamination, enhancement of the elimination of toxicants, supportive treatment.

Dr. Poór Miklós

5 Drug intoxications I. - Drugs decreasing consciousness.

Dr. Poór Miklós

6 Drug intoxications II. - Drugs causing agitation.

Dr. Poór Miklós

7 Drug intoxications III. - Drugs causing cardiac dysfunction.

Dr. Poór Miklós

8 Drug intoxications IV. - Drugs causing metabolic disorder or tissue necrosis.

Dr. Poór Miklós

9 Toxic hypoxias I. - Toxic gases (carbon monoxide, hydrogen cyanide and cyanogen compounds, hydrogen sulfide).

Dr. Poór Miklós

10 Toxic hypoxias II. - Methemoglobin formers.

Dr. Poór Miklós

11 Toxicology of solvents I. - General properties, hydrocarbons and their halogenated derivatives.

Dr. Poór Miklós


47

12 Toxicology of solvents II. - Alcohols and carbon disulfide.

Dr. Poór Miklós

13 Toxicology of metals I. - General properties, protective mechanisms, metal chelators.

Dr. Poór Miklós

14 Toxicology of metals II. - Lead, mercury, cadmium, and arsenic.

Dr. Poór Miklós

15 Toxicology of pesticides I. - General properties, insecticides, herbicides.

Dr. Poór Miklós

16 Toxicology of pesticides II. - Fungicides, rodenticides, fumigants.

Dr. Poór Miklós

17 Poisonous mushrooms.


18 Chemical warfare agents.


19 Chemical carcinogenesis I. - Historical examples, genotoxic carcinogens.


20 Chemical carcinogenesis II. - Non-genotoxic carcinogens, the process of carcinogenesis.


21 Chemical teratogenesis I. - Historical examples, human chemical teratogens.


22 Chemical teratogenesis II. - Teratogenic drugs, developmental toxicology.


23 Toxicity testing.


24 Risk assessment.


25 Summary, consultation I.

Dr. Poór Miklós

26 Summary, consultation II.

Dr. Poór Miklós

27 -

Dr. Poór Miklós

28 -

Dr. Poór Miklós

29 -

Dr. Poór Miklós

30 -

Dr. Poór Miklós

Practices

Seminars


The exam includes each topic discussed during the lectures and presented in lecture slides (available in Neptun Meet Street). Those have

not achieved at least 70% in mid-term tests have to take an oral exam (during the exam period). In addition to the exam topics, an

important part of the exam is answering questions that aim at assessing the general knowledge of the student. Students have to discuss

in details two major exam questions; however, those who did not achieve 50% in the mid-term tests need to explain two additional

topics as well.

Exam topics/questions:

1. The scope of toxicology. Human intoxications: occurrence and classification. Causes of poisoning-related death.

2. Management of the poisoned patient: emergency care, diagnostics, decontamination, antidotes, enhancement of the elimination of

toxicants, supportive care.

3. Drug intoxications I: drugs decreasing consciousness, drugs causing agitation.

4. Drug intoxications II: drugs causing cardiac dysfunction, metabolic disorders, or tissue necrosis.

5. Toxic hypoxias: carbon monoxide, hydrogen cyanide and cyanogen compounds, hydrogen sulfide, methemoglobin formers.

6. Toxicology of solvents: hydrocarbons and their halogenated derivatives, alcohols, carbon disulfide.

7. Toxicology of metals: metal chelators, protective mechanisms, toxic effects of metals.

8. Toxicology of pesticides: general properties, insecticides, herbicides, fungicides, rodenticides, and fumigants.

9. Poisonous mushrooms.

10. Chemical warfare agents.


48

11. Chemical carcinogenesis.

12. Xenobiotic-induced fetal malformations.

13. Toxicity testing and risk assessment.

Participants


49

OPG-U3E-T PHARMACEUTICAL PRACTICE AND MANAGEMENT 2 - THEORY






Topic

The lectures of the semester will further outline the pharmaceutical supply system, especially in community and clinical practice, and

pharmaceutical care. Interactive discussions will cover essential topics regarding self-medication, patient counselling and over the

counter products used in minor diseases. Main aim of these studies is to solidify pharmacy practice and related knowledge in legislation,

health economics, marketing and pharmaceutical care, in order to understand pharmacoeconomics, drug allocation, pharmaceutical

management, evidence based medicine, clinical pharmacy services.

The course will introduce the basic function of the health care system and pharmaceutical supply chain in respect of general legal,

pharmaceutical, economical, marketing relations and specialties. Further, the fundamentals of health economics and pharmaeconomics,

the concepts of pharmaceutical care and the basic tasks and services in hospital and clinical pharmacy are covered to support pharmacists;

clinical knowledge. Development of legal norms, hierarchy of norms, patients rights, claim for damages and other legislative aspects of

pharmacy practice are introduced in this semester. Lectures will cover basic knowledge regarding marketing and specific issues in

marketing for pharmacists.




Acceptance of term/semester:


- Assignments given in class should be carried out during term-time, further OTC presentations and Evaluation of counseling

skills in practice (these are criterion requirements for the course) must be completed, and

- mid-term and end-of-the term test be written/taken. Passing the tests is not obligatory for semester acceptance; however

advisable as you will likely have better results and a good recommended grade for PPM2. There is a retake opportunity only for the end-

of-the term test.

Mid-term exams

Mid-term tests: During the semester a mid-term test will be written. In case of unsuccessful or missed test, additional questions will be

added to the end-of-the-term test. The number of additional questions may vary regarding the number of unsuccessful or missed mid-

term tests. There is no re-examination opportunity for the unsuccessful or missed mid-term tests.

End-of-the-term test: On the last week of the semester, a test will be written on the whole semester”s curriculum. Further additional

questions are included in the end-of-the-term test, if the student has not carried out an assignment during the semester. The number of

these questions may vary according to the unsuccessful or missed assignments. In case of unsuccessful or missed end-of-the term test,

one re-examination opportunity is granted to make up during the last week of the semester.



Reading material




MeetStreet.

- Notes


C. Bond (ed.): Evidence-based Pharmacy, Pharmaceutical Press, London, 2002.

A. J. Winfield, R. M. E. Richards (eds.): Pharmaceutical Practice, Churchill Livinstone

C. H. Knowlton, R. P. Penna (eds.): Pharmaceutical Care, ASHSP

M. Stephens (ed.): Hospital Pharmacy, Pharmaceutical Press, London, 2006.


Walker, Roger: Clinical Pharmacy and Therapeutics, 2011.

Edzard Ernst, Simon Singh: Trick or Treatment, W. W. Norton & Company, 2008. Section IV: Nutrition and Nutritional Supplementation, Section XI: Complementary and Alternative Medicine.

Edzard Ernst, Simon Singh: Trick or Treatment? Alternative Medicine on Trial


Paul Rutter: Community Pharmacy - Symptoms, Diagnosis and Treatment 4th Edition. Elsevier 2017


50

Lectures

1 Communication: Strategies to meet specific needs 1

Dr. Miseta Ildikó

2 Communication: Strategies to meet specific needs 2

Dr. Miseta Ildikó

3 Introduction to the hospital and clinical pharmacy 1


4 Introduction to the hospital and clinical pharmacy 2


5 Communication skills in hospital practice


6 Electronic communication is healthcare, pharmacists in the social media 1.

Dr. Miseta Ildikó

7 Hospital pharmacy services 1

Dr. Vincze Patricia Anna

8 Hospital pharmacy services 2


9 Helping patients manage therapeutic regimens. Supporting behaviour change


10 Electronic communication in healthcare, pharmacists in the social media 2.

Dr. Miseta Ildikó

11 Adherence 1


12 Adherence 2


13 Interactive discussion and comparative evaluation of different Health Care Systems 1.






16 International Health Organizations, National and International Pharmaceutical Organizations


17 Fundamentals of Health Economics, Health Policy

Dr. Bella Richárd

18 The function of norms in society. The general characteristics of legal norms.

Dr. Bella Richárd

19 The sources of law.

Dr. Vajda Péter

20 Functions and institutions of a modern state. The role of public administration.

Dr. Bella Richárd

21 Courts and judicial remedies.

Dr. Vajda Péter

22 Patient rights 1.


23 Patient rights 2.


24 The Costs of Health Care, the Benefits of Health Care.

Dr. Bella Richárd

25 Health Expenditures, Cost Control Techniques.


26 Prices of Drugs.





Dr. Botz Lajos


51

Practices

Seminars

1 Insect bites, stings, Tics, Scabies, Pediculosis


2 Oral pain and discomfort, herpes labialis, aphthous stomatitis


3 Prevention of pregnancy, pregnancy tests and STD-s


4 Vitamins, nutrition and drug therapy during pregnancy


5 Diaper dermatitis


6 Menstruation, biliary and urinary stones


7 Benign Prostatic Hyperplasia

Dr. Bella Richárd

8 Pharmaceutical Care: Metabolic syndrome 1.


9 Pharmaceutical Care: Metabolic syndrome 2.


10 Pharmaceutical Care: Hypertension


11 Pharmaceutical Care: Diabetes mellitus


12 Pharmaceutical Care: Dyslipidemia


13 Midterm-test


14 Main Pharmacoeconomic Evaluations 1. Theoretical

Dr. Bella Richárd

15 Main Pharmacoeconomic Evaluations 2. Practical

Dr. Bella Richárd

16 Decision tree- practical

Dr. Bella Richárd

17 Decision tree- practical

Dr. Bella Richárd

18 Quality of life - practical


19 Placebo 1.

Dr. Bella Richárd

20 Placebo 2.

Dr. Bella Richárd

21 Introduction to and history of marketing.


22 The Market & The customer-perceived value







End-of-the-term test is organized in Neptun Unipoll at the regular time of lectures. The test will be on the whole semester’s curriculum.

Additional questions can be included in the end-of-the-term test, if the student has not carried out an assignment during the semester

or in case of unsuccessful midterm test.





52


pharmacotherapy module, the mid-term test and the end-of-the term test. The practice part must be completed and accepted (criterion

requirements) for all students, however depending on the recommended curriculum students may not receive a separate practical

grade.

Participants

Dr. Bella Richárd (IL65ZJ), Dr. Fittler András Tamás (IYR5HQ), Dr. Somogyi-Végh Anna (CPFSLI), Dr. Vida Róbert György

(BN08GS), Dr. Vincze Patricia Anna (XE52I7)


53

OPG-U3G-T PHARMACEUTICAL PRACTICE AND MANAGEMENT 2 - PRACTICE






Topic

The lectures of the semester will further outline the pharmaceutical supply system, especially in community and clinical practice, and

pharmaceutical care. Interactive discussions will cover essential topics regarding self-medication, patient counselling and over the

counter products used in minor diseases. Main aim of these studies is to solidify pharmacy practice and related knowledge in legislation,

health economics, marketing and pharmaceutical care, in order to understand pharmacoeconomics, drug allocation, pharmaceutical

management, evidence based medicine, clinical pharmacy services.

The course will introduce the basic function of the health care system and pharmaceutical supply chain in respect of general legal,

pharmaceutical, economical, marketing relations and specialties. Further, the fundamentals of health economics and pharmaeconomics,

the concepts of pharmaceutical care and the basic tasks and services in hospital and clinical pharmacy are covered to support pharmacists;

clinical knowledge. Development of legal norms, hierarchy of norms, patients rights, claim for damages and other legislative aspects of

pharmacy practice are introduced in this semester. Lectures will cover basic knowledge regarding marketing and specific issues in

marketing for pharmacists.




Acceptance of term/semester:


- Assignments given in class should be carried out during term-time, further OTC presentations and Evaluation of counseling

skills in practice (these are criterion requirements for the course) must be completed, and

- mid-term and end-of-the term test be written/taken. Passing the tests is not obligatory for semester acceptance; however

advisable as you will likely have better results and a good recommended grade for PPM2. There is a retake opportunity only for the end-

of-the term test.

Mid-term exams

Mid-term tests: During the semester a mid-term test will be written. In case of unsuccessful or missed test, additional questions will be

added to the end-of-the-term test. The number of additional questions may vary regarding the number of unsuccessful or missed mid-

term tests. There is no re-examination opportunity for the unsuccessful or missed mid-term tests.

End-of-the-term test: On the last week of the semester, a test will be written on the whole semester”s curriculum. Further additional

questions are included in the end-of-the-term test, if the student has not carried out an assignment during the semester. The number of

these questions may vary according to the unsuccessful or missed assignments. In case of unsuccessful or missed end-of-the term test,

one re-examination opportunity is granted to make up during the last week of the semester.



Reading material




MeetStreet.

- Notes


C. Bond (ed.): Evidence-based Pharmacy, Pharmaceutical Press, London, 2002.

A. J. Winfield, R. M. E. Richards (eds.): Pharmaceutical Practice, Churchill Livinstone

C. H. Knowlton, R. P. Penna (eds.): Pharmaceutical Care, ASHSP

M. Stephens (ed.): Hospital Pharmacy, Pharmaceutical Press, London, 2006.


Walker, Roger: Clinical Pharmacy and Therapeutics, 2011.

Edzard Ernst, Simon Singh: Trick or Treatment, W. W. Norton & Company, 2008. Section IV: Nutrition and Nutritional Supplementation, Section XI: Complementary and Alternative Medicine.

Edzard Ernst, Simon Singh: Trick or Treatment? Alternative Medicine on Trial


Paul Rutter: Community Pharmacy - Symptoms, Diagnosis and Treatment 4th Edition. Elsevier 2017


54

Lectures

Practices

1 Pharmaceutical Care: evolution, principles.

Dr. Télessy István

2 Pharmaceutical Care: feasibility and technique, legal framework, levels


3 Pharmaceutical Care: Special populations


4 Pharmaceutical Care: Asthma. Allergic rhinitis, COPD 1


5 Pharmaceutical Care: Asthma. Allergic rhinitis, COPD 2


6 Definition and history of marketing


7 The pharmaceutical and healthcare market


8 Decision Analysis

Dr. Bella Richárd

9 Decision Tree

Dr. Bella Richárd

10 Midterm-test


11 Drug Utilization Studies


12 Quality of Life


13 Marketing mix and SWOT analysis


14 Marketing Communication, Regulations on Drug-Advertising


15 Life cycle management


16 Price strategies, Distribution






Seminars


End-of-the-term test is organized in Neptun Unipoll at the regular time of lectures. The test will be on the whole semester’s curriculum.

Additional questions can be included in the end-of-the-term test, if the student has not carried out an assignment during the semester

or in case of unsuccessful midterm test.





pharmacotherapy module, the mid-term test and the end-of-the term test. The practice part must be completed and accepted (criterion

requirements) for all students, however depending on the recommended curriculum students may not receive a separate practical

grade.

Participants

Dr. Bella Richárd (IL65ZJ), Dr. Fittler András Tamás (IYR5HQ), Dr. Somogyi-Végh Anna (CPFSLI), Dr. Télessy István (YL0Y6I), Dr.

Vida Róbert György (BN08GS)


55

OPO-KE2-T PUBLIC HEALTH 2

Course director: DR. ISTVÁN ZOLTÁN KISS, professor

Department of Public Health Medicine [email protected]

3 credit ▪ semester exam ▪ Med.-biol. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 8



Topic

Public Health represents the preventive side of medicine. The subject deals with primary, secondary and tertiary prevention of the most

challenging diseases of public health.

The aims are to exam the process of disease development and demonstrate the possibilities of prevention on individual and community

levels.


Participation in practicals is obligatory which is registered.

Absences should not exceed 2x45 min. Otherwise signature of grade book is denied.

Mid-term exams


There are no make-up classes.

Reading material


Edit Paulik: Public Health and Preventive Medicine, Medicina Publishing House, Budapest 2013.


Educational material uploaded on Neptun.

- Notes


Lectures

1 Health effects of alcohol consumption and smoking I.

Dr. Berényi Károly

2 Health effects of alcohol consumption and smoking II.

Dr. Berényi Károly

3 Global drug trends. Drug trends in Hungary I.

Dr. Szabó István

4 Global drug trends. Drug trends in Hungary II.

Dr. Szabó István

5 Basics of toxicology.

Dr. Szabó István

6 Epidemiology of poisonings.

Dr. Szabó István

7 Basics of occupational health.

Dr. Németh Balázs

8 Health effects of mechanical, ergonomic and psychological factors.

Dr. Németh Balázs

9 Occupational carcinogens I.


10 Occupational carcinogens II.


11 Basics of environmental health.

Dr. Varga Csaba

12 Environmental health; global trends.

Dr. Varga Csaba

13 Air pollution.

Dr. Szabó István

14 Air pollution.

Dr. Szabó István


56

15 Water hygiene, soil pollution I.

Dr. Varga Csaba

16 Water hygiene, soil pollution II.

Dr. Varga Csaba

17 Basics of infectious diseases.

Dr. Németh Katalin

18 Epidemiology of infectious diseases: global situation.

Dr. Németh Katalin

19 Epidemiology of airborne diseases I.

Dr. Németh Katalin

20 Epidemiology of airborne diseases II.

Dr. Németh Katalin

21 Epidemiology of infectious diseases transmitted by food and water I.

Dr. Németh Katalin

22 Epidemiology of infectious diseases transmitted by food and water II.

Dr. Németh Katalin

23 Epidemiology of sexually transmitted diseases.

Dr. Németh Balázs

24 Hepatitis

Dr. Németh Balázs

25 Haematogenic and lymphogenic infections. Epidemiology of infections transmitted through the skin.

Dr. Németh Katalin

26 Epidemiology of zoonoses.

Dr. Németh Katalin

27 Prion diseases. New infectious diseases.

Dr. Varga Csaba

28 Public health methods in disasters. Chemical and biological weapons, (bio)terrorism.

Dr. Szabó István

Practices

1 General epidemiology; meta-analysis, systematic review, databases

Dr. Lohner Szimonetta Ivett

2 General epidemiology; meta-analysis, systematic review, databases

Dr. Lohner Szimonetta Ivett

3 Nosocomial infections; Disinfection and sterilization

Dr. Gyöngyi Zoltán

4 Nosocomial infections; Disinfection and sterilization

Dr. Gyöngyi Zoltán

5 Chemical and microbiological qualification of drinking water

Dr. Szendi Katalin

6 Chemical and microbiological qualification of drinking water

Dr. Szendi Katalin

7 Vaccination, vaccination schedule

Dr. Szendi Katalin

8 Vaccination, vaccination schedule

Dr. Szendi Katalin

9 Genotoxicity laboratory practical I.

Dr. Szendi Katalin

10 Genotoxicity laboratory practical II.

Dr. Szendi Katalin

11 Chemical safety, risk assessment

Dr. Varga Csaba

12 Chemical safety, risk assessment

Dr. Varga Csaba

13 Health effects of radiation

Dr. Szendi Katalin

14 Health effects of radiation

Dr. Szendi Katalin


57

Seminars


1. Primary and secondary factors of epidemic process (virulence, source of infection, means of transmission, susceptible host)

2. Nosocomial infections. Sterilization, disinfection

3. Infectious diseases worldwide

4. Prevention of infectious diseases. Managing epidemics. Vaccination, chemoprophylaxis.

5. Epidemiology and prevention of vaccine-preventable diseases, mandatory immunisation for children

6. Epidemiology and prevention of airborne bacterial infections

7. Epidemiology and prevention of airborne viral infections

8. Epidemiology and prevention of enteric bacterial infections

9. Characteristics, types, occurrence and prevention of enteric viral infections

10. Epidemiology and prevention of enteric helminth and protozoon infections

11. Epidemiology and prevention of viral hepatitis

12. Epidemiology and prevention of haematogenic and lymphogenic infections

13. Epidemiology and prevention of infections transmitted through the skin

14. Epidemiology and prevention of zoonotic infections

15. Epidemiology and prevention of sexually transmitted diseases (excluding AIDS)

16. Epidemiology and prevention of AIDS

17. Epidemiology and prevention of prion diseases

18. New infectious diseases. Bioterrorism

19. Epidemiology of alcohol consumption

20. Epidemiology of smoking

21, Epidemiology of drug use

22. Basics of toxicology. Epidemiology of poisonings.

23, Basics of occupational health.

24, Health effects of mechanical, ergonomic and psychological factors.

25, Occupational cancers

26. Basic principles of ecology. Human environment, human ecology.

27, Outdoor air pollution

28, Indoor air pollution.

29, Environmental-health of water.

30. Health effects of soil contamination. Health effects and management of waste water, wastes and hazardous wastes

Practicals:

31. Criteria of the meta-analyses and the systematic review

32. Health effects of microbiological and chemical water pollutants, water quality testing

33, Genotoxicity

34. Occupational toxicology: chemical safety

35, Risk assessment, management and communication

36, Health effects of radiation

Participants

Dr. Gyöngyi Zoltán (E8QLIG), Dr. Lohner Szimonetta Ivett (ZVSVRK), Dr. Szendi Katalin (MRDJ71), Dr. Varga Csaba (WU90WK)

STUDY PROGRAM 2021/2022 Subjects of the 7-8. semesters ...

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