STRUCTURED WATERSTRUCTURED WATERpHpH

and CANCERand CANCER

Mariano BizzarriDepartment Experimental Medicine and Pathology

University La Sapienza

IS THERE ANY RELATIONSHIP IS THERE ANY RELATIONSHIP BETWEEN CANCER andBETWEEN CANCER and

CELL WATER STRUCTURE ?CELL WATER STRUCTURE ?

First suggestions were made by Albert Szent-Gyorgi (1957):Reduced ratio between structured-bounded/free water

Nuclear magnetic resonance relaxation and water contents in normal mouse and rat tissuesand in cancer cells.J Natl Cancer Inst. 1980 May;64(5):1199-1207. Ling GN, Tucker M.

High intracellular levels of K+ and Na+ induce water structure Breaking

Science, 1971, 171: 1151-1153, Damadian R.

FREE WATER

BOUNDED WATER

STRUCTURED WATER

HYDROPHOBIC DOMAINS

HYDRATATION FORCES

M

V

MEMBRANE

MACROMOLECULES

SOLUTION AMORPHE SOLID CRISTAL

STATISTICALLY HOMOGENE ENVIRONMENT

M2

M1

M3

M4

HETEROGENE ENVIRONMENT

INADEQUACY of CLASSICS CHEMICAL and PHYSICAL LAWS

M5

M6 M7