Status Report Euro-BioImaging - J Ellenberg S Schönberg Report Euro... · Euro)BioImaging!Hub!...

Euro-‐BioImaging

4th Stakeholder Mee7ng January 21-‐22, ACV Vienna

Jan Ellenberg and Stefan Schönberg Euro-‐BioImaging Scien9fic Coordinators

Participate in the Revolution in Bioimaging Technologies

Strong Pan-European Support

250 Euro-‐BioImaging Partners from 28 countries

Na9onal investment made or planned, EuBI on roadmap

in 12 countries

39 Legal Partners, 250 Associated Partners from 28 Countries, > 270 Letters of Intent , > 1400 Stakeholders

19 na9onal imaging communi9es formed in

Key added values of a European RI

Why should European countries invest into and run a European distributed research infrastructure for biological and medical imaging?

No single European country can run cuBng-‐edge facili9es for all exis9ng and new imaging technologies: 1.  By coordina9ng and integra9ng its efforts, Europe can achieve and maintain

leadership in imaging technologies in the global research landscape.

2.  A pan-‐European commitment to imaging infrastructure will provide long-‐term sustainability for research infrastructure in imaging technologies.

3.  Na9onal scien9sts will gain open access to all relevant imaging technologies they need in partner countries delivered by the best experts in the field.

National Imaging Initiatives in 19 countries

e.g.

...

National Imaging Infrastructure with Open Access for national users

Examples of exis9ng and planned na7onal research infrastructures

Nodes of European significance. AMrac9ve and open for transna9onal access.

National Contribution to European research infrastructure

Mul9modal Technology Nodes

Single Technology Flagship Nodes

Euro-‐BioImaging Hub

Distributed research infrastructure model for Euro-BioImaging

MULTIMODAL TECHNOLOGY NODES provide excellence by integra9on of mul9ple imaging technologies at one site TE

CHNOLO

GY NODE

S

WITH OPEN USER AC

CESS

SINGLE TECHNOLOGY FLAGSHIPS offer an innova9ve technology at European leading level

Euro-‐BioImaging HUB (Responsibili9es: coordina9on & support, access, data, training;

Executes board decisions e.g. evalua9on, upgrade decommissioning; external representa9on)

Na9onal imaging infrastructure e.g. France-‐BioImaging, GEBI, …

EURO

-‐BIOIM

AGING IN

FRASTRUCTU

RE

> 19 COORDINATED NATIONAL IMAGING INITIATIVES

Operational Model

MULTIMODAL TECHNOLOGY

NODE

Imaging Infrastructure with physical open user access

FLAG

SHIP NODE

FLAG

SHIP NODE

FLAG

SHIP NODE

FLAG

SHIP NODE

USER TR

AINING STAFF TRAIN

ING

Web-‐access portal

European life scien9sts as users

Data storage and analysis infrastructure

User goes home with results for publica9on

HUB

NODE

S MULTIMODAL TECHNOLOGY

NODE

Testing the Infrastructure Model: Proof-of-Concept Studies

Major results •  Euro-BioImaging received 228 user applications from 23 European countries,

as well as USA, Australia, and Singapore. •  More than 110 users visited 51 imaging facilities in 14 European countries

from January to July 2012.

•  In total, more than 60% of all users applied for transnational access, 89% left their home town for getting access.

Proof-of-Concept Studies

Imaging technologies tested for open and transna7onal user access

PCS Results

38

3

13

5

28

2

0

7

6

5

2

0

0

0 5 10 15 20 25 30 35 40

WP6 Mul9-‐modal integrated ALM

WP7-‐ CLEM

WP7-‐ Func9onal Imaging

WP7-‐ High-‐throughput

WP7-‐ Super Resolu9on

WP8-‐ Mesoscopic Imaging

WP8-‐ Probes ALM

WP8-‐ Mul9-‐Modal Molecular Imaging

WP8-‐ Probes MI

WP9-‐ HF-‐MRI

WP9-‐ PCI

WP10-‐ Image guided Therapy

WP10-‐ Popula9on

Number of user access based on PCS survey

17

2

2

2

1

4

3

4

3

3

Number of visited facili9es

Changing the European Infrastructure Landscape

Collaboration Framework Agreement between Euro-BioImaging and AMMRF

Jan Ellenberg (Scientific Coordinator, Euro-BioImaging) and Simon Ringer (Executive Director, AMMRF), after signing the collaboration framework agreement. EMBL Heidelberg, Feb 1st, 2012

International relations: Australia

Collaboration Framework Agreement between Euro-BioImaging and India BioImaging in preparation

International relations: India

INDIA BioImaging

Jan Ellenberg and Antje Keppler (Euro-BioImaging) at the inauguration of INDIA BioImaging. NCBS Bangalore, Sep 21st, 2012

“This experience has given novel stimuli to my studies. Furthermore, I have set the bases for future experiments developed in collaboration with the Advanced Light Microscopy Facility. I thank the Euro-BioImaging initiative for having given me this opportunity.” (I.A. Asteriti)

Italia Anna Asteri7, CNR -‐ Ins9tute of Molecular Biology and Pathology, Rome, Italy. Visited the Advanced Light Microscopy Facility of the EMBL (Heidelberg)

Used technology High throughput microscopy Results A large number of data, assaying within the same experiment several doses of the Aurora-‐A inhibitor and prolonging the observa9on over long 9mes, were acquired. The obtained results will be likely to contribute to the understanding of the mito9c roles of Aurora-‐A, as well as to a future ra9onalisa9on of the use of Aurora-‐A inhibitors in cancer therapy.

Biological Imaging PCS study (1 of 89): From cell biology to cancer therapy: a high-throughput microscopy approach for the study of Aurora-A inhibition in human cells

U2OS cells pre-‐synchronised at the G1/S transi9on (snapshot from a movie).

Petra Kolenc Peitl, University Medical Centre Ljubljana, Slovenia Visited the Radboud University Nijmegen Medical Centre

Used technology SPECT/CT Results The study allowed the quantification of radionucleotide-labeled peptides in the kidneys providing new insights on how to improve kidney protection in peptide receptor radionuclide therapy in the future.

Molecular imaging PCS study (1 of 13): Stereochemistry of amminoacid spacers determines the pharmacokinetics of 111In-DOTA-minigastrin analogs for targeting of the gastrin receptor

Comparison of kidney reten9on of two In-‐111 labeled minigastrin analogues.

“I found really inspiring that I was never just an observer but I was an ac9ve actor from the beginning to the end, having the possibility to work with a small animal-‐dedicated SPECT/CT machine. There was always technical support available from nice and very well skilled people. This concept of work makes the interpreta9on of the final results much easier since you are aware of the cri9cal points in each individual step that leads to the final result.”

Karsten Specht, University of Bergen, Norway Visited the Leibniz-‐Ins7tute for Neurobiology, Magdeburg, Germany

Results The results are indica9ng a differen9al func9onal asymmetry of the different phone9c aspects, i.e. the lej and the right auditory system responds differently to them. This gives further evidence to current models on the func9onal asymmetry of speech percep9on and helps further iden9fying the informa9on flow in the brain.

Medical Imaging PCS study (1 of 7): Information integration, transcallosal communication, and inter-individual variability during the processing of voiced and unvoiced consonants in speech signals

Used technology: 7T MR scanner

“The en9re process around the Euro-‐BioImaging PCS studies was very smooth and s9mula9ng. It was a unique opportunity to conduct a study that could complement my earlier studies. “ (K. Specht)

Major results – Imaging facility perspective •  The staff efforts for user management, sample-preparation and hands-on user

training were much higher in most cases than anticipated.

•  For providing external access in the future, additional staff is needed.

•  The average duration of the user visit lasted 2 weeks.

•  97% of the participating facilities would offer open access in the future after capacity upgrade.


Major results – User perspective

•  All users rate the Euro-BioImaging PCS access policy (central online application, communication, transparency, time until access) to be very good to excellent.

•  >70% of users rate the validity of the obtained results to be very good to excellent for publication.

•  >90% state that the benefit of the PCS was worth the effort of traveling.

•  99% of users would make use of Euro-BioImaging open access facilities in the future.


The Euro-BioImaging infrastructure model is requested by users and works

•  97% of the facilities would offer open access after capacity upgrade.

•  99% of the users would use of Euro-BioImaging open access facilities.

•  Over 60% transnational access, 89% of users left their home town.

2012 2013 2014

From Planning to Construction

Criteria for nodes

Governance & Legal

Structure

  Survey   PCS   Natl. Communi7es

Infrastructure model for each

imaging technology

Tech

nica

l WP

s

Stra

tegi

c W

Ps

Finance Plan

✔

✔

Business plan

Open Call for EuBI Nodes

Negotiation with Member States = EuBI Partners

Euro-BioImaging Infrastructure

construction operation

1st Open Call for Euro-‐BioImaging Nodes – Expressions of Interest

How to become a EuBI Node

1st Open Call

Euro-BioImaging Nodes – Expression of Interest

The 1st Open Call runs from 25 January – 30 April 2013

Focuses on nodes that provide physical open access to imaging technologies that have demonstrated feasability by e.g. PCS

Imaging technologies that were successfully evaluated in PCS:

Multi-modal Advanced Light Microscopy Correlative Light-Electron Microscopy Functional Imaging Super Resolution Microscopy High-throughput Microscopy Mesoscopic Imaging Multi-Modal Molecular Imaging Probes-Molecular Imaging Phase contrast Imaging High-field MRI MRI-PET (evaluated by alternative proof-of-feasibility)

Eligibility

•  Applicant demonstrates the user need for new capacity (LeMers of Intent from 50% of external users but max. 30 leMers)

•  Applicant guarantees to provide open access for Euro-‐BioImaging users to at least 50 % of new capacity (comprises instrument 9me, staff capacity, storage capacity, …)

•  Applicant demonstrates exis9ng communica7on with na7onal/regional funders for infrastructure capacity upgrade

•  The applicant demonstrates that the single-‐sited or mul9-‐sited Node will cons9tute a legal en7ty, which in its en9rety will become part of Euro-‐BioImaging and as such a legal contractual partner of Euro-‐BioImaging

•  Applicants from ESFRI Countries are eligible.

General Review

General Review Criteria

The following General Review Criteria should be addressed in each Expression of Interest: •  Scientific and technical excellence of the infrastructure Node •  Quality and scientific field of the academic environment •  Geographic coverage •  Maintenance and update •  European and national significance •  Access and service package •  Use and quality assurance •  User training •  If applicable, evidence of funding commitment by national funders

Technology Specific Review

Common Technology Review Criteria

Technology Specific Review

Specific Technology Review Criteria – Example: High-throughput Microscopy

•  Large-‐scale reagent libraries for cell or organism perturba9ons (e.g. siRNA , cDNA or chemical libraries)

•  Support in assay development and adapta9on of low throughput laboratory assays to automa9on

•  Support in high-‐throughput sample prepara9on (e.g. cell seeding devices, liquid handling, robots)

•  High-‐throughput image acquisi9on technology and live cell imaging •  Support in large-‐scale data management and handling •  Tools and support for automated image analysis of large data sets •  Tools and support for data mining and evalua9on tools •  Large-‐scale compu9ng (“cluster”) to enable rapid analysis of large data sets

1st Open Call: 25 Jan – 30 Apr 2013

•  1st Call focuses on technologies that will provide physical open access to imaging technologies

•  Eligible applicants will be reviewed by general and technology specific review criteria

•  Addi9onal imaging technologies will be added in future open calls ajer passing the Euro-‐BioImaging technology iden9fica9on process: 1.  Demonstrate user need for (new) imaging technology 2.  Develop research infrastructure model for providing open access to

this imaging technology 3.  Demonstra9on of feasibility in PCS

Summary Open call for Nodes

To Dos for Node applicants

1.  Contact your national imaging community. 2.  Talk to your national funders.

3.  Submit your Expression of Interest online until April 30th.

Forms and templates will be available on the Euro-BioImaging website on January 25th, 2013.

Webportal

Biological Imaging Jan Ellenberg (Scientific Coordinator) Antje Keppler (Project Manager) [email protected]

Medical Imaging Stefan Schönberg (Scientific Coordinator) Pamela Zolda (Project Manager) [email protected]

www.eurobioimaging.eu

Status Report Euro-BioImaging - J Ellenberg S Schönberg Report Euro... · Euro)BioImaging!Hub!...

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