SmartSphinctre - Nano-Tera 2016

7/26/2019 SmartSphinctre - Nano-Tera 2016

1/18

SmartSphincter

Lukas Brgger, Philippe Bchler, Christian Gingert, Franc Hetzer,

Urs Sennhauser, and Bert Mller

Mid-term !aluati"n Meeting, Lausanne, #$ %pril #&'(


2/18

SmartSphincter a device to treat fecal incontinence

University of Basel #Bert Mller, &)*##*#&'(

+ Fecal inc"ntinence F. means l"ss "/ c"ntr"l "/ de/ecati"n pr"cess0

+ 1!erall pre!alence "/ F in adults is 2et3een '' 4 and '5 40 t

increases 3ith age0

+ %ppr"6imatel7 "ne third "/ pe"ple li!ing in retirement h"mes "r similar

instituti"ns are a//ected - a2"ut 85 4 in U0S0 and ur"pe0+ 9ue t" the underrep"rted nature "/ F, it is likel7 that its true

pre!alence is e!en higher0

+ 9iapers can palliate 2ut in se!ere cases the patient needs an

appr"priate de!ice*implant0


3/18

Natural anal sphincter and currently used devices

University of Basel )

%nnals "/ Bi"medical ngineering, :"l0 88, ;"0 5, Ma7 #&'(, pp0 ')55


4/18

Need for a biomimetic device with sensory feedback

University of Basel 8



5/18

Actuation principles for artificial sphincters

University of Basel 5Bert Mller, &)*##*#&'(

%nnals "/ Bi"medical ngineering,

:"l0 88, ;"0 5, #&'(, pp0 ')55


6/18

Roadmap of approaches toward breakthrough in non-

biological artificial sphincter development

University of Basel (Bert Mller, &)*##*#&'(



7/18

SmartSphincter project overview

Bert Mller, &)*##*#&'( University of Basel $

Clinical studies

Smart nan"structures

lectr"nics

Bi"mechanical m"del

Bi"mimetic actuat"r

%ut"n"m"us s7stem


8/18

Clinical studies

University of Basel ?

@"2ia Brusa, 9aniel %2ler, Aadu @utuian, Peter Studer, lisa Fatt"rini, Christian Gingert, Lukas 0

Brgger and Philippe Bchler

Combining FLIP with anatomical information A novel method to assess the compliance of the anal

sphincter muscles

;eur"gastr"enter"l"g7 M"tilit7 #&'(. 3ith the auth"rs /"r /inal appr"!al

Bert Mller, &)*##*#&'(

%nat"m7 and m"rph"l"g7 "/ the anal canal /"r the determinati"n "/ ge"metr7length, thickness. and mechanics E-m"dulus. as 3ell as /uncti"nal

parameters such as cl"sing pressure0

+ %nat"m7 !ia MA and US

+ Mechanical pr"perties !ia /uncti"nal luminal imaging pr"2e FLP. and high-

res"luti"n anal man"metr7 HA%M.

+ Clinical stud7 "n healthy volunteers /inished.

+ Clinical stud7 "n patients recruitment and start.


9/18

Anal sphincter properties uideline

University of Basel =Bert Mller, &)*##*#&'(

Passi!e parameters male * /emale.>

Length, "uter radius> #= 8. mm, '? '. mm * #8 5. mm, '8 #. mm

Em"dulus se!eral '& kPa

%cti!e parameters>

Pressure at rest> 5# mmHg * 8$ mmHg

Pressure at sDueeze> '5( mmHg * $$ mmHg

%S

FLP

%S

'& ml #& ml )& ml 8& ml 5& mlFLP !"lume>


10/18

Artificial muscles based on dielectric elastomer

actuators

University of Basel '&Bert Mller, &)*##*#&'(

E Sel/-supp"rting structure

E %deDuate length change

E :er7 l"3 electrical p"3er c"nsumpti"n

E Materials a!aila2le

< Large actuati"n !"ltage k:.

Scienti/ic challenge> 10,000-layer

sub-micrometer-thin sandwich-structure

'&&&&

la7ers

U )&:

U )&:' m

thickness


11/18

!olecular beam deposition with in situ ellipsometry

University of Basel ''Bert Mller, &)*##*#&'(

@0 @Ipper et al0, Tailoring the mass distribution

and functional group density of dimethylsiloane!

based films by thermal evaporation"%PL

Materials,re!isi"n su2mitted #&'(.

F0 M0 Jeiss et al0, #olecular beam deposition of high!permittivity

polydimethylsiloane for nanometer!thin elastomer films in dielectric

actuators" #aterials and $esign" re!isi"n su2mitted #&'(.

n-situ ellips"metr7 all"3s m"nit"ring

/ilm gr"3th

re/racti!e inde6 sur/ace r"ughness

p"r"sit7


12/18

Alternating current electro-spray deposition

University of Basel '#Bert Mller, &)*##*#&'(

F0 Jeiss et al0 Electrospraying nanometer!thin elastomer films for low!voltage dielectric actuators , %d!0 lectr"n0 Mater0

'5&&8$(, "nline #&'(. d"i>'&0'&*aelm0#&'5&&8$(

F0 Jeiss et al0 Thin film formation and morphology of electro!sprayed polydimethylsiloane, Langmuir 32#&'(. )#$(

F0 Jeiss et al% Electro!spraying and ultra!violet light curing of polydimethylsiloane to fabricate thin films for low!voltage

dielectric elastomer actuators" Pr"c0 SP 979#&'(. =$=?)C


13/18

Nanometer-thin "#!S deposition by electrospray

University of Basel ')Bert Mller, &)*##*#&'(

F0 Jeiss et al0, Electrospraying nanometer!thin

elastomer films for low!voltage dielectric actuators ,

%d!0 lectr"n0 Mater0 '5&&8$(, "nline #&'(.d"i>'&0'&*aelm0#&'5&&8$(

F0 Jeiss et al0, Thin film formation and morphology of

electro!sprayed polydimethylsiloane, Langmuir 32

#&'(. )#$(-)#?)


14/18

!ulti-stack actuators

University of Basel '8Bert Mller, &)*##*#&'(

B0 1smani et al%, &tress measurements of planar

dielectric elastomer actuators, Ae!0 Sci0 nstrum0

re!isi"n su2mitted #&'(.

M0 Karapetk"!a, Masters thesis Bi"medical

ngineering, @H rich #&'(.

denti/7 "ptimal adhesi"n la7ers andph"t"-initiat"rs

ngineer "lig"mers 3ith

ad!antage"us /uncti"nal gr"ups

Use "/ mechanical pr"cessing steps,

e0g0 pre-straining

1ptimize pr"cess relia2ilit7 and

scala2ilit7

Multi-stacked actuat"rs 3ith MB9 and

electr"spra7 dep"siti"n

0 1 0 00 . 0

0 . 1

C

u

rv

a

tu

re

(m

-1)

V o l t a g e ( V )

4 L a y e r s 3 L a y e r s 2 L a y e r s 1 L a y e r


15/18

System overview

University of Basel '5Bert Mller, &)*##*#&'(

Aece

i!erc"il

@ran

smitterc"il

!

"B#$

%9ielectric elast"mer

actuat"r*sens"r%

nerg7 st"rage

and c"ntr"l electr"nics

%Charger

%9ata trans/er


16/18

$attery selection and testing as well as transcutaneous

energy transfer inductive power transfer

University of Basel '(Bert Mller, &)*##*#&'(

6periments t" estimate p"3er

c"nsumpti"n, selecti"n "n

appr"priate 2atteries

Great2atch #$=), capacit7 ##& m%h,

n"minal !"ltage )0$ :

Batter7 endurance stress test at 2"d7temperature )$ C. c"nsidering

stand27 and actuat"r use

C7cle time c"mpressi"n /act"r> #?0?,

i0e0 N actuat"r c7cles in '& 7ears

tested 3ithin 80' m"nths

//icienc7 measurements as the

/uncti"n "/ tissue thickness /r"m 5 t"

#5 mm


17/18

%nergy harvesting e&periments designed

University of Basel '$Bert Mller, &)*##*#&'(

Stud7 3ith #& health7 !"lunteers t" measure the am"unt "/ energ7 gained 27

2"d7 acti!ities like m"!ement and 2reathing as 3ell as /r"m temperature

di//erences

+ Kinetic energ7 !ia magnetic inducti"n, piez"electric and electr"static

appr"aches using acti!e and passi!e m"!ement+ @hermal energ7 !ia temperature gradients 2et3een 2"d7 and en!ir"nment

+ 9e!ices selecti"n, pr"2a2l7 c"m2inati"n

+ Ae!ie3 article pending, "nl7 /irst dra/t a!aila2le p"stp"ned.

+ Aesults imp"rtant 2e7"nd the current pr"Oect

Humanenergyharvesting

Kinetic energy

Thermal energy

acti!e

passi!e


18/18

Conclusions

University of Basel '?

+ Clinical studies 3ith !"lunteers ha!e 7ielded e6perimental data t"select ge"metr7 and mechanics "/ the actuat"r0 9e!ices /"r male and

/emale 3ill di//er0 9e!ice /"r /emales ha!e pri"rit70

+ lectr"spra7ing m"nit"red 3ith ellips"metr7. and c"m2ined 3ith ultra-

!i"let light curing all"3s /"r the preparati"n "/ ultra-/lat nan"meter-thin

/ilms 3ith rates at least "ne "rder "/ magnitude /aster than MB90

+ P"3er suppl7 and electr"nics are designed, sh"uld 2e impr"!ed, and

c"mplemented 27 energ7 har!esting0

+ Much attenti"n has 2een gi!en t" the scienti/ic papers cp0 ;e3s, Uni

Basel ( %pril #&'(., 2ut pr"t"t7pe de!el"pment is /"cus "/ acti!ities0

@he /inancial supp"rt "/ the nan"-tera0ch initiati!e is grate/ull7 ackn"3ledged0

Bert Mller, &)*##*#&'(

SmartSphinctre - Nano-Tera 2016

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