Simulation by Design - A Healthcare Focus

© 2011 ANSYS, Inc. October 10, 20111

Simulation by Design

A healthcare focusDr. Mike Slack

ANSYS Technical Services


What does simulation promise?


ANSYS

• ANSYS have been around for 40 years.

• Has the biggest and most diverse customer base in simulation.

• A simulation company succeeds by evolving the way our products work to meet the needs of our customers.


Presentation objectives

Why simulation

–Business drivers for simulation.

–How ANSYS simulation fits a healthcare business

–How it enables virtual prototyping

–The Future


But First ...

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Conservation of Mass

Conservation of Momentum

The Navier-Stokes Equation for fluid flow


• Eqn. is complex so lets make things easier

• You can either simplify the equation or the shape of the domain.

• We discretise our domain into simple shapes - a computational mesh.

• We now need a computer to calculate how each shapeinteracts with its neighbours.

Using a computer to solve flow eqns.

control volume

CFD - ComputationalFluid Dynamics


So now we can model a race car


Business Drivers for simulation


The healthcare sector

• A high value growth sector– Increased spending on Health

– Aging more active presentation – Customised patient specific treatment

• Regulatory and technological demands have seen simulation tools playing an increasingly vital role.

– Design, development and understanding of medical devices, effective drug delivery and bio processing


The importance of Innovation

• It is critical to not only maintain but to accelerate and innovate.

• Innovation brings game changing technology.

Ipad tablet. A brand new concept. Sweeps into the market

Joseph Lister's reduced death rate from 45.7%. To 15% with the introduction of his new antiseptic treatment.


Top Health Care Companies Rely on ANSYS Simulation


Business Driver - Risk

Admired companies, known for their good products, experience trouble because a lack of product Integrity!

“The cost of getting it wrong and the value of getting in right have never been greater.”


Innovation

“ I’m not in the business of predicting, I’m in the business of innovating. We need the tools to predict with confidence so our product is right the first time. ”

David Stanbridge, CEO at Swift Technology Group


Accuracy

“By using an anisotropic hyperelastic material model in ANSYS Mechanical we are able to accurately predict the quality of motion of the natural and the implanted spine.

Using ANSYS software allows us to perform hundreds of design iterations in the same amount of time it would take to run a single cadaveric test.”

Jorge A. Ochoa, Ph.D., P.E., CTO - Archus Orthopedics


Time

"The ability to evaluate different designs with CFD without building prototypes drastically reduced the amount of time needed to bring the glucose monitor to market.“

Dr. Ron Kurnik - Cygnus Therapeutic Systems


Top Product Design Challenges

47%

41%

36%

28%

24%

0% 10% 20% 30% 40% 50%

Problems/errors found too late

Making trade-offs for cost, performance and quality

Frequent design changes

Predicitng product behavior in a real world environment

Workforce reductions / lack of technical experts

Top Product Design Challenges

Source: Aberdeen Group. April 2010

Percentage of Respondants; n=157


The process of testing Ideas


Co

st o

f ch

ange

Concept Design

Review

Prototype Production Operation

Its better to make mistakes early


1990’s

History of simulation in design

Today


Test Your Concepts

Evaluate the current

– Develop your knowledge and experience in new technology areas.

Try out your ideas

– Establish what works and understand why

– Understand the impact of scale

– Review your best concepts


Testing and healthcare

• Why?

– Biomechanical testing is required before implanting in the human body

– Preclinical tests help protect patients from ineffective devices

– Experimental and computational models provide insight about what happens in the real system, provide focus and therefore reduce more costly tests

Simulation

PhysicalModels

AnimalExperiments

Increasing Cost

Incr

easi

ng

Bio

logi

cal

Rel

evan

ce

* Prendergrast and Maher J Mat Proc Tech (2001)

Preclinical Testing


Have Confidence in your design

Provide evidence to back up your concept.

Communication

3D visualisation and numerical data will demonstrate and provide confidence to your internal and external customers.

Simulation provides evidence to differentiate your design.


Range of Healthcare Applications


The FCC ruled in February, 2011 that the finite element method (FEM) is a valid technique to simulate a medical device that must communicate with other similar devices.

Electromagnetic implants

E field produced by Implant Antenna

Far Field of Implant Antenna


ANSYS Solutions for Process and manufacture


Virtual prototyping


Virtual prototyping

• Refine the design - establish the most sensitive parameters.

• Satisfy regulatory demands by demonstration and explanation, simulation can support and document compliance.

• Investigate the robustness of your product ensuring it achieves all of its promise.


Central to Simulation Driven Product Development

• Move from a single design point solution to understanding the design space so simulation can guide design

• Design exploration answers the big questions

Single point What if?Response surface

?

??

Go Beyond the Single Design Point…


Dyson Reinvents the Fan

• Safe device...

• Explored 10x design variations per day.

• Improved performance 250% over original design

• Continuous airflow!


New Technology and R&D Activities


Old Paradigms

Single Physics

Single Component Simulation by a Single Person

Idealized geometries

Few Design Points Studied

Long Pre-Clinical/Clinical Testing

New Paradigms

Multiphysics Simulation(flow, thermal, structural, electromagnetic, acoustic, etc.)

Collaborative MultidomainSimulation (component and system)

Patient-Specific Testing on Large Patient Database

Extensive Design Exploration

In Silico Testing Validated through Few (pre-)Clinical Checks

ANSYS Vision for Healthcare Industry


Assess your design in a multiple physics environment

Power loss distribution

Radio FrequencyVibration stress

Flow and Cooling


System Design - ANSYS Simplorer

Simulink

IcePak Simulation

ANSYS Mechanical

Maxwell

Q3DFluent

CustomModel, C


HBM full physics

Application areas:• Coronary stents• Peripheral stents• Artificial organs

Application areas:• Orthopaedic implants• Exercise equipment

Application areas:• Transdermal• Inhalers• Oral• Intrathecal

Application areas:• Medical imaging• Cardiology products• Drug delivery

CARDIOVASCULAR DRUG DELIVERYMUSCULOSKELETAL ELECTROMAGNETICS


Summary


Summary

Simulation

• Do the what if’s

• Refine through virtual Prototyping

• Have confidence in your design

• Compliments regulatory approval

Simulation by Design - A Healthcare Focus

Health & Medicine

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