Respiration 4 link and krebs
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Transcript of Respiration 4 link and krebs
![Page 1: Respiration 4 link and krebs](https://reader036.fdocuments.in/reader036/viewer/2022062706/557dd3d3d8b42a124f8b4832/html5/thumbnails/1.jpg)
2 x 3C pyruvate
2 x 3C triose phosphate
6C hexose bisphosphate
Glucose (6C hexose)
Pyruvate actively pumped into mitochondrial matrix
2x NADH produced from NAD
4x ATP produced
2x ATP used
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Glycolysis (cytoplasm)…
Glucose (6C hexose)
6C hexose bisphosphate
2 x 3C triose phosphate
2 x 3C pyruvatePyruvate actively pumped into mitochondrial
matrix
2x ATP used
4x ATP produced
2x NADH produced from NAD
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Substrate Level Phosphorylation
• Formation of ATP from ADP and Pi during glycolysis and the Krebs cycle
http://www.northland.cc.mn.us/biology/biology1111/animations/glycolysis.html
http://www.science.smith.edu/departments/Biology/Bio231/glycolysis.html
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The Link Reaction
• (i) state that the link reaction takes place in the mitochondrial matrix;
• (j) outline the link reaction, with reference to decarboxylation of pyruvate to acetate and the reduction of NAD;
• (k) explain that acetate is combined with coenzyme A to be carried to the next stage;
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Key terms
Decarboxylation and dehydrogenation
• Decarboxylation – removal of a carboxyl group from a chemical compound, usually with hydrogen replacing it
• Dehydrogenation – removal of a hydrogen from a chemical compound
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Draw the Link Reaction
• (i) state that the link reaction takes place in the mitochondrial matrix;
• (j) outline the link reaction, with reference to decarboxylation of pyruvate to acetate and the reduction of NAD;
• (k) explain that acetate is combined with coenzyme A to be carried to the next stage;
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Pyruvate (3C)
Acetate (2C)
Acetyl CoA (2C)
CO2NAD+NADH
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What enzymes are involved?
1. A hydrogen atom is removed from pyruvate
2. A carboxyl group is removed from pyruvate (the carboxyl group will eventually become carbon dioxide)
What type of substance are NAD and Coenzyme A?
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The Krebs Cycle
• (l) state that the Krebs cycle takes place in the mitochondrial matrix;• (m) outline the Krebs cycle, with reference to the formation of citrate
from acetate and oxaloacetate and the reconversion of citrate to oxaloacetate (names of intermediate compounds are not required);
• (n) explain that during the Krebs cycle, decarboxylation and dehydrogenation occur, NAD and FAD are reduced and substrate level phosphorylation occurs;
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Krebs Cycle
• http://highered.mcgraw-hill.com/sites/007352543x/student_view0/chapter8/how_the_krebs_cycle_works.html
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Can You Remember?
6 5 4 4 4 4
NAD NAD ATP FAD NAD
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Link Reaction and Krebs Cycle
• http://www.youtube.com/watch?v=KZYtwtNrAm8
• http://www.youtube.com/watch?v=ti6-57yK5RY
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• Answer Stretch and Challenge Question P89
• Expand the table P89 to include glycolysis