Ras-Raf-MAPK SHCGrb2SOS1 P P P Raf1 P MEK2 P MEK1 P Grb2, growth factor receptor-bound protein 2 Ras...
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Transcript of Ras-Raf-MAPK SHCGrb2SOS1 P P P Raf1 P MEK2 P MEK1 P Grb2, growth factor receptor-bound protein 2 Ras...
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Ras-Raf-MAPK
SHCGrb2
SOS1
PP
P
Raf1Raf1P
MEK2P
MEK1P
Grb2, growth factor receptor-bound protein 2
RasRas
ERK2ERK2
ERK1ERK1
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SHCGrb2
SOS1
PP
P
Raf1Raf1P
MEK2P
ERK2ERK2P
P
ERK1ERK1 PP
MEK1P
Transcription factorsTranscription factorsGrb2, growth factor receptor-bound protein 2; SRF, serum response factor
RasRas
SRF SRFTranscriptionTranscription
Ras-Raf-MAPK
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Attivazione costitutiva di Ras-Raf-MAPK
Raf1Raf1P
MEK2P
ERK2ERK2P
P
ERK1ERK1 PP
MEK1P
SRF SRF
RasRas
TranscriptionTranscription
Ras
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Zarnestra (Tipifarnib, R115777) Sarasar (Lonafarnib, SCH66336)
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EVIDENCE FOR ARas-INDEPENDENT EFFECT FOR FTIs
•Lack of correlation between susceptibility and Ras status
•Differences in the kinetics of development of the effects • Inhibition of K-Ras- and N-Ras-dependent cell growth
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REOVIRUS (Respiratory Enteric Orphan Virus)
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Attivazione costitutiva di Ras-Raf-MAPK
Raf1Raf1P
MEK2P
ERK2ERK2P
P
ERK1ERK1 PP
MEK1P
SRF SRF
RasRas
TranscriptionTranscription
Ras
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SORAFENIB (Nexavar®): Low molecular weight inhibitor of VEGFR,
PDGFR, KIT, RET and Raf-1 kinase activity
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Mechanism of action of sorafenib