Protein structureTertiary Structure – Interactions

Tertiary Structure Interactions

Disulfide Bridges

• 2 Cysteines undergo oxidation to form disulfide

bridge

Tertiary Structure

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Salt bridge (ionic bond) forms between

amino acids with acidic and basic side

chains

Tertiary Structure

Hydrogen bonds form between side chains of

amino acids

(Different from hydrogen bonds in secondary structure which form

between backbone atoms)

Tertiary Structure

Hydrophobic interactions (due to London forces)

between nonpolar amino acid side chains occur in

interior of proteins

Hydrophobic Effects

Exterior of Protein mostly hydrophilic amino acid

Slice through middle of protein

shows hydrophobic amino acids in interior of protein