Presentation of ALGEBAKT project. Antibacterial effect of arctic macroalgae species DMV, PhD,...
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Transcript of Presentation of ALGEBAKT project. Antibacterial effect of arctic macroalgae species DMV, PhD,...
Presentation of ALGEBAKT project.Antibacterial effect of arctic macroalgae
species
DMV, PhD, Margarita Novoa-Garrido
Alta, Norway, Sept, 6th - 8th, 2010: The 7th Circumpolar Agricultural Conference"Circumpolar Agricultural and Land Use Resources - Prospects and Perspectives for Circumpolar Productions and Industries"
The MABIT-programme is an industrial R&D program for Northern Norway.
Bioforsk Nord Bodø. Bioproduction and ecosystems along the coast
Coastal ecology - possibilities for commercial exploitation of coastal and marine resources without damaging ecosystems. Our main focus is the algae.
• Antibiotics: therapy and growth promotion
• Ab-resistance• Antibiotics banned in Europe
as antibiotic growth promoters since 2006
Background for the project
Antibiotic resistance test of P. aeruginosa strain
It was on a short-cut through the hospital kitchens that Albert was first approched by a member of the Antibiotic Resistance.
Palmaria palmata
Pelvetia canaliculata Alaria esculenta
Foto: Unni Lorentsen
A. nodosum
ALGINATE
SEAWEED MEAL Sheep in seaweed meal project in
Bioforsk Nord.Foto: H.J. Skulstad
L. hyperboreaA. nodosum
Vegetables in seaweed project in Bioforsk Nord.Foto: I. Øvsthus
Algae composition
• Dietary fibre (<8% DM)• Protein (5-10 % DM)• Fat (2-4 % DM)• Carbohydrates (45-60 % DM)
• Vitamines: A, C, E, B1, B2, B3, B8, B9
• Minerals• Secundary bioactive metabolites
Macroalgae biologiske effekter
• Antibakterial• Antivirus• Antitumor• Antioxidant• Antiinflammatory• Immune stimulans• Growth stimulant
Animal health
Diet
Environment
Bacterial population
Immune system
Jejunum and ileum104-106 CFU/mlLactobacilli, coliforms,Streptococci, fusobacteria, clostridia, bacteriodes, bifido bacteria
Stomach up to 102
Lactobacilli, streptococci, yeast
Colon 1010-1012
CFU/mlLactobacilli, bifido bacteria, eubacteria, fusobacteria, coliforms, clostridia, veillonella, yeasts
Photo: Birger Volden
Some research results
• Animal husbandry: nr. of E. coli intestine, shedding of E. coli O157 and Salmonella, nr. adherent Lactobacillus sp. Innate immunity and B lymhocyte activity.
• Aquaculture: Antibacterial effect on fish pathogens such as Vibrio sp. and Aeromonas sp.
• Furanones, organohalogens, floratannins, fucoidans, haloperoxidases, alginate
Aims of the project
• Generate knowledge about bioactive components with antibacterial effect in macroalgae species adapted to the northern Norwegian climate to get a better overview of the potential for developing new products based on their antibacterial property.
Material and methods
• Bacteria sheep: Lactobacillus sp., Enterococcus faecium, Enterococcus faecalis, different E. coli strains
• Bacteria fish:Vibrio sp., Pseudoalteromonas sp., Aeromonas sp.
• Macroalgae: Four red species and two brown species
• Minimum inhibitory concentration (MIN)• Liquid chromatography-mass spectrometry
Synergy with other ongoing prosjects
• «Natural sources of antioxidants – a necessity for animal health and welfare and product quality in organic livestock production.»
• The research Council of Norway.• Effekt of feeding macroalgae on the milk
quality of dairy cattle.• Effekt of feeding macroalgae on intestinal
bacterial flora and immune system of sheep.
Future visions
• Screening• Identification of biologically activ components• Animal experiments
THANK YOU FOR YOUR ATTENTION!