Portinari: A Data Exploration Tool to Personalize Cervical ... · Manoel Horta Ribeiro†, Raquel...
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Portinari: A Data Exploration Tool to Personalize Cervical Cancer Screening Sagar Sen ∗ , Manoel Horta Ribeiro † , Raquel C. de Melo Minardi † , Wagner Meira Jr. †, Mari Nygård ‡ ∗ Certus V&V Center and HPV Research Group, † Department of Computer Science, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, ‡ HPV Research Group, Cancer Registry of Norway, Oslo, Norway 1
Transcript of Portinari: A Data Exploration Tool to Personalize Cervical ... · Manoel Horta Ribeiro†, Raquel...
Portinari: A Data Exploration Tool to Personalize Cervical
Cancer Screening Sagar Sen∗, Manoel Horta Ribeiro†, Raquel C. de Melo Minardi†, Wagner Meira Jr.†,Mari Nygård‡
∗ Certus V&V Center and HPV Research Group, † Department of Computer Science, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, ‡ HPV Research Group, Cancer Registry of Norway, Oslo, Norway
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Software’s Impact in Societal Processes
Through which means societies organize themselves?
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Software’s Impact in Societal Processes
politics
Through which means societies organize themselves?
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Software’s Impact in Societal Processes
politics
Through which means societies organize themselves?
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Software’s Impact in Societal Processes
politics
Through which means societies organize themselves?
social bonds
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Software’s Impact in Societal Processes
politics
Through which means societies organize themselves?
social bonds
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Software’s Impact in Societal Processes
politics
Through which means societies organize themselves?
social bonds labour
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Software’s Impact in Societal Processes
politics
Through which means societies organize themselves?
social bonds labour
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Self-organizing vs. Centralized
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Self-organizing vs. Centralized
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Self-organizing vs. Centralized
vs
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Self-organizing vs. Centralized
vs
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Norway’s Screening Program
Cytology
Unsatisfactory 1 -3 months
HPV-test
HPV +ve6 - 12 months
HPV Normal3 years
New Cytologyand HPV-
test
ASC-US/LSILImmediately
Cytology Normal 3 years
Colposcopywith biopsy
AGUS/ASC-H/HSIL/ACIS/CaImmediately
HPV Normal and Cytology Normal/ASC-US3 years
HPV +veImmediately
HPV Normal and LSIL or LSIL/AGUS/
ASC-H/ACIS/CaImmediatelyEntry intro screening program
25-69 years of age
DefinitionsACIS: Adenocarcinoma in situAGUS: Atypical glandular cells of undetermined significance, under cell. ASC-H: Irregular squamous cells with changes suggestive of high grade lesion, but do not meet all the criteria for diagnosisASC-US: Irregular squamous cells with abnormalities of uncertain significanceCa: All types of cancerCytology: Test to look at abnormal cellsHPV: Humanpapillomavirus HSIL: High-grade squamous intraepithelial lesionLSIL: Low-grade squamous intraepithelial lesion
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Triage Algorithm
Screening Exams
Invitation and Reminders
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Triage Algorithm
Screening Exams
Invitation and Reminders
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Triage Algorithm
Screening Exams
Invitation and Reminders
Verification and Validation
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Triage Algorithm
Screening Exams
Invitation and Reminders
Verification and Validation
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Triage Algorithm
Screening Exams
Invitation and Reminders
Verification and Validation
Statistics by epidemiologists
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Triage Algorithm
Screening Exams
Invitation and Reminders
Verification and Validation
Statistics by epidemiologistsData exploration and visualization
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What data?
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What representation?
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Querying
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Portinari Flow Diagrams of Future Paths
The flow diagram s t a r t s w h e r e t h e query patterns ends, showing
Each layer represents the distribution of diagnosis n exams into the future.
Hovering over the edges or nodes of the graph shows stats!
Portinari allows two charts to be displayed side by side!
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Explorations
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Exploring effects of screening guidelines
Cytology Normal Cytology Normal
3-4 years
What happens after 3 years to this cohort?
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261133 individuals
230,331 individuals
39 individuals
Next Diagnosis in 3 years
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280572 individuals
193543 individuals
Next Two Diagnoses
Did not return
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Exploring existing screening guidelines
Cytology Normal Cytology Normal
3-4 years
What if women come back in the next 30 days?
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4337 individuals
Cytology not good
enough for some?
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Cytology Normal HPV +ve
next exam
Comparing two scenarios in the triage algorithm
Come back within 1 year
Come back in 1 to 2 years vs.
(Guideline)
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Returned in 1 -2 yearsReturned within 1 year
13297individuals
278individuals
(19)6.83%
HPV +ve
(227) 1.61%
HPV +ve
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Conclusion➤ Alternative way of verifying and validating paths
taken by people in a socio-technical system.
➤ Use of easy-to-query graph database.
➤ Generalizable to event-driven data.
➤ Generation hypothesis for further statistical investigation.
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https://github.com/manelhr/portinari/
homepages.dcc.ufmg.br/~manoelribeiro/
manoelribeiro
Questions?
Manoel Horta Ribeiro
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https://github.com/manelhr/portinari/
homepages.dcc.ufmg.br/~manoelribeiro/
manoelribeiro
Questions?
Manoel Horta Ribeiro
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