Individualised Prescribing.

AQUAMAX® Filter

The AQUAMAX® range of polyethersulfone membranes are engineered to meet the needs of all patients with clinical indications for CRRT :

Acute Kidney Injury (AKI)

Fluid overload

Sepsis

Post-operative surgical care1

Optimised for convective and diffusive therapies (CVVH, CVVHD, CVVHDF)2

High hydraulic permeability providing exemplary fluid removal (SCUF)3

Excellent clearance of small and medium sized molecules4

Indicated for all forms of CRRT anticoagulation5

Choice of four filters with varying membrane surface areas

Individualise your therapy, without changing the membrane.

All CRRT indications, one filter.

PM-0112-09/2016-1 Copyright 2017. All rights reserved.

www.nikkisoabp.com

AQUAMAX®, AQUALINETM and AQUASET® are trademarks of Nikkiso Co., Ltd.

AQUAMAX® Hemofilter Nikkiso Belgium bvba Industriepark 6 3300 Tienen Belgium

AQUALINE Tubing Haemotronic S.p.A. Via Carreri,16 41037 Mirandola Italy

AQUASET & CITRASET RCA Assembled by Haemotronic Via Carreri,16 41037 Mirandola Italy

AQUAMAX® is included in every AQUASET®*

1 Bent et al., Early and intensive continuous hemofiltration for severe renal failure after cardiac surgery. 2001 Annals of Thoracic Surgery, March, Volume 71, Issue 3, Pages 832-837.2 Ballestri et al., Ultrastructural Features of Polyethersulfone Membranes. Discussion, Page 25, para 2, lines 5-9. In: Locatelli et al (eds). Polyethersulfone: Membranes for Multiple Clinical Applications. 2003. Contributions to Nephrology 138, ISBN 3-8055-7485-1.Karger, Basel.

3 Bagshaw S, Brophy P, Cruz D, Ronco C, Commentary, Fluid balance as a biomarker: impact of fluid overload on outcome in critically ill patients with acute kidney injury. Critical Care 2008, 12:169 (doi:10.1186 / cc6948)

4 Schindler R, Elimination of Cytokines from Plasma by Ultrafiltration, Using Conventional Polysulfone or DIAPES membranes. Discussion: Page 41, para 2, lines 4-7. In: Locatelli et al (eds). Polyethersulfone: Membranes for Multiple Clinical Applications. 2003. Contributions to Nephrology 138, ISBN 3-8055-7485-1.Karger, Basel.

5 AQUAMAX®, Instructions for use, 07-2015 IB0510133110-REV.006 Brandt T, Weise F, Physical and Chemical Characteristics of Different Polyethersulfone Membranes. Principles of Membrane Manufacturing, Page 6, lines 4 -7. In: Locatelli et al (eds). Polyethersulfone: Membranes for Multiple Clinical Applications. 2003. Contributions to Nephrology 138, ISBN 3-8055-7485-1.Karger, Basel.

AQUAMAX® Filter

Characteristics5 AQUAMAX® HF03 AQUAMAX® HF07 AQUAMAX® HF12 AQUAMAX® HF19Membrane surface area (m2) 0.3 0.7 1.2 1.9Priming volume (ml) 32 49 73 109Pressure drop (mmHg) < 40 < 80 < 50 < 25

Performance features5

Clearance (ml / min) at Qb 200 ml / min Qd 300 Qd 500 Qd 300 Qd 500 Qd 500 Qd 500Urea 79 82 152 162 186 192Creatinine 74 77 142 151 174 183Phosphates 69 71 134 143 168 179Vitamin B12 45 46 112 118 139 150KUF (ml/h x mmHg) 16 16 33 33 51 60

Membrane: High-flux Polyethersulfone | Thickness: 30 µm | Inner diameter: 200 µm | Sterilisation: Ethylene Oxide | Single use only

*available in selected countries

Colour coded end caps Correct orientation and optimal blood flow5

Standard ISO and Luer-lock fittings One standard connection, one standard AQUAMAX® for all CRRT modalities

AQUAMAX® Polyethersulfone Membrane pore size allows middle molecules up to 55KDa to be removed including selected cytokines / inflammatory mediators associated with sepsis using convective therapies4

Membrane High hydraulic permeability with structural strength in each fibre, providing enhanced convective and diffusive properties2

Spacer yar n s Prevents clustering of capillaries and enables even distribution of dialysate maximising clearance6

Ultrafiltration versus blood flow5

AQUAMAX® HF19

AQUAMAX® HF12

AQUAMAX® HF03