p21 mechanism slide
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G1 M S G2 R p53 Direct p21 transcription Inactive CDK T P T-loop ATP 161 14 CDK PSTAIRE NH 2 T Y 15 p21 G1 Arrest Cell cycle arrest mediated by p53 target p21 (WAF1) DNA damage El-Deiry et al., Cell 75:817, 1993 5,934 citations as of 4-13 The most highly cited original MS in Cell
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Transcript of p21 mechanism slide
G1 M
S
G2
R
p53
Direct p21 transcription
Inactive CDK T P
T-loop
ATP 161 14 CDK
PSTAIRE NH2 T Y 15
p21
G1 Arrest
Cell cycle arrest mediated by p53 target p21 (WAF1)
DNA damage
El-Deiry et al., Cell 75:817, 1993
5,934 citations as of 4-13 The most highly cited original MS in Cell