Biomedical R&D Folie (slide) 1 Saratin - mechanism of action vWF Platelet.
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Transcript of Biomedical R&D Folie (slide) 1 Saratin - mechanism of action vWF Platelet.
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Biomedical R&D
Folie (slide) 1
Saratin - mechanism of action
vWF
Platelet
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Biomedical R&D
Folie (slide) 2
Saratin - mechanism of action
vWF
Platelet
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Biomedical R&D
Folie (slide) 3
Saratin - mechanism of action
Platelet
vWF
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Biomedical R&D
Folie (slide) 4
Saratin - mechanism of action
vWF
Platelet
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Biomedical R&D
Folie (slide) 5
Saratin - mechanism of action
Platelet
vWF
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Biomedical R&D
Folie (slide) 6
Saratin - mechanism of action
vWF
Platelet
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Biomedical R&D
Folie (slide) 7
Saratin - mechanism of action
Platelet
vWF
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Biomedical R&D
Folie (slide) 8
Saratin - mechanism of action
Platelet
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Folie (slide) 9
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Folie (slide) 10
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Folie (slide) 12
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Folie (slide) 13
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Folie (slide) 15
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Vessel wall injury exposes collagen to elements of flowing blood.
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Folie (slide) 26
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vWF A3 domain binds to collagen.
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vWF A1 domain targets GP Ib/IX/V receptor of circulating platelets, “tethering” them to the vessel wall.
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Folie (slide) 35
Saratin - mechanism of action
Direct collagen-platelet interactions (GP Ia/IIa, GP VI etc.) anchor and then lead to activation of the tethered platelet.
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Occlusivethrombus!
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How does saratin interfere with arterial thrombosis?
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S
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SS
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SSS
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S
Saratin binds to collagen, preventing interaction with vWF and hence platelets.
SSS
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SSSS
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SSSS
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SSSS
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SSSS
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Saratin - mechanism of action
Saratin acts as a molecular plaster, neutralising platelets BEFORE they adhere and become activated.
SSSS