Overview of Sjogren’s Syndrome: Robert I. Fox, MD., Ph.D. Scripps Memorial and Ximed La Jolla, CA.
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Transcript of Overview of Sjogren’s Syndrome: Robert I. Fox, MD., Ph.D. Scripps Memorial and Ximed La Jolla, CA.
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Overview ofSjogren’s Syndrome:
Robert I. Fox, MD., Ph.D.
Scripps Memorial and Ximed
La Jolla, CA
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It is a great honor to provide an overview for our distinguished experts
• Dr. Stephen Cohen--Eye
• Dr. Avu Wu--Mouth
• Dr. Daniel Sauder--Skin
• Dr. Fisher--Sleep
• Dr. Nichols--GI
• Dr. Wallace--Lupus
• Dr. Cohen--New Drugs
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Goals
• 1. Emphasize that evaluation of Sjogren’s is different from a disorder like Rheumatoid Arthritis
• 2. Recognize that Sjogren’s patient has symptoms that often do not correlate closely with laboratory abnormalities
• 3. In development of future therapy, we have to take a broader point of view to understand the basis of Sjogren’s symptoms
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Sjogren’s Syndrome-is important to recognize and treat
but receives little attention even from the American College of Rheumatology
• “Quality of life”- patients equated the impact of dryness in Sjogren’s on their life
• a) at same level of limitation as patients with moderate angina
• b) they are willing to give up 2 years of life!!! to not have this condition
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Factors not generally considered or measured with lab tests
• “Disability” is most commonly due to fatigue and cognitive impairment
• “Limitations” on daily activities: dry eyes (limits work- especially computer) dry mouth (limits sleep and social interactions around eating) extra-glandular manifestations, particularly neurologic
• “Expense of artificial tears and dental decay
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Typical Clinical Features of dry eyes, dry mouth and swollen glands
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Dryness results in the clinical appearance of keratoconjunctivitis sicca (KCS)characteristic of Sjogren’s syndrome
The upper lidliterally sticks to
the surface epithelial surface and pulls
surface mucin layers off. The Rose Bengal
dye retentionis like
“rain water pooling in a street pothole”
This test can be done at bedside
and allows“triage” and rapid referral of patientsto Ophthalmology
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Severe Xerostomia with dry tongue
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Sjogren’s Syndrome- Cervical Dental Caries
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In Sjogren’s syndrome:there is often a poor correlation
between how the patient feels and the laboratory tests.
This frustrates both patients and doctors.
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The labs and the symptoms: Take Home Lessons-1
We measure blood counts, sedimentation rates and auto-antibodies. This gives an idea of the “activity” of the immune system based on lymphocyte hormones.
However, these lab tests do not often correlate well with the patient’s symptoms.
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The key to understanding this imbalance of labs and symptoms
Recognition that lymphocyte hormones (which is what we are really measuring indirectly through our lab tests) influence:
• the nerve’s function to activate glandular secretion
• the nerve’s ability to transmit sensations of pain or discomfort
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The Functional Circuit
• The functional circuit refers to the “nerve” input from eye and mouth to the central nervous system.
• In other words, the threshold for sensing “pain or dryness” may differ in individual patients.
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Normal tearing or salivationsecretion requires a functional unit
Nerves on mucosal4. Stimulation
of gland
2. Midbrain ofcentral nervous
system3. Stimulationof blood vessel
Afferent nerves
3. Cortical OutflowTractsand HPA
Lacrimatory or salivatory nuclei
watermucinprotein
waternutrientshormones
1. Ocular or oral surfaceirritation
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In Sjogren’s syndrome, the release of neural transmitters --and the response of the glands to neural transmitters--
are impaired by lymphocytes that enter the gland and release inflammatory factors
ocular and oral dryness
Focal lymphocyticinfiltrates in the
glands
lymphocytes
Gland dysfunction•Autoantibodies (anti-muscarinic antibody)
Cytokines (type I IFN, -IFN)
•Metalloproteinases (outside-inside signaling
molecules)
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In Sjogren’s, only 50% of the acini and ducts are destroyed.Despite their retention of neural innervation, the residual
glands do not function as a result of the inflammatory environment
Sjogren’s Normal
Foci of lymphs
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Thus, the interesting question is:
Why are the residual glandular elements not working?
This fundamental question of how immune and neural systems interact will be the “holy grail” of neuroscience
for the next decade.
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In addition to the symptoms
SS has lymphoproliferative properties—
it lies on the border between autoimmunity and
lymphoma.
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Sjogren’s Syndrome – with parotid enlargement indicates lymphoproliferative tendency
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The normal salivary gland is not a lymph node.
Why are there lymphocytes in the salivary gland?
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Part of the cause of Sjogren’s is that lymphocytes “home” to the glands
1. T- and B-cells have surface “homing receptors” when generated in node or marrow.
CD4+CD4+
B cellB cell
BloodBlood
3. When the homing receptor encountersvascular adhesive molecules,the lymphocyte enters tissue.
2. Lymphs migrate through blood
to tissues.
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Time course of autoimmune response*1. Genetic factors predispose to Sjogren’s
2. Environmental factor such as a viral infection leads to autoantibody.2. Antibodies precede disease.3. Presence of antibody does not mean disease.
GeneticFactors
(including sex)(HLA-DR)
GeneticFactors
(including sex)(HLA-DR)
GeneticFactors
(including sex)(HLA-DR)
GeneticFactors
(including sex)(HLA-DR)
Auto-antibodies
AcquiredImmune system
(HLA-DR)T/B-cells
DiseaseManifestations
Time period of years
InnateImmune system
(Toll receptor)
GeneticFactors
(including sex)(HLA-DR)
EnvironmentalFactor
(virus-such as EBV)(apoptotic fragment)
Type I IFNImmunecomplex
Ref. 32-33
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Overview of Symptoms
When we get “flu symptoms” of joint pain, fatigue, foggy thinking—
it is a result of the lymphocyte hormonesreleased by the immune system.
When these reactions persist in genetically predisposed individual by the immune system,
the result is autoimmune disease.
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Summary-1
Sjogren’s syndrome represents the interface of:
a) Immune and exocrine secretory functions (dryness)
b) Immune and neural function (neuropathy/cognitive)
c) Immune and hypothalamic-adrenal axis (endocrine)
d) Autoimmune proliferation and lymphoma
e) Lupus-like features of vasculitis and immune complex
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Summary-2
1. Extraglandular manifestations are determined by lymphocyte homing to tissues-- factors that govern their retention in tissues and their apoptosis.
2. Factors governing their clonal expansion and lympho-proliferation lead to lymphoma-derived from B-cells themselves, T-cells, and dendritic cells.
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Summary -2Why is SS predominantly in women
• X-chromosome location of Toll receptor;
• X-linked genes for apoptosis;
• X-linked genes for transcription promoter of
pro-inflammatory loci including NF-K;
• X-linked control of metalloproteinase
release under hormonal regulation.
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Treatment of Sjogren’s in 2012:Opportunities and Challenges
a) Treatment of Dry Eyes and Mouth
b) Treatment of Extraglandular Manifestations--
• Lupus like symptoms-arthralgia, rash
• Neuropathy (central and peripheral)
• Cognitive and myalgia (fibromyalgia)
• Lymphoproliferative
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Thank you for coming
• I will now take questions
• Or if there is time, I can describe a bit about how we are approaching this problem of functional circuit in association with colleagues at Scripps and Salk
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Neuropathy
• Poor correlation between symptoms and objective findings:
– Eye pain- does not correlate with tear flow;– Mouth pain-not correlate with saliva;– Peripheral neuropathy-not correlate with nerve
biopsy;– Cognitive-not correlate with acute phase
reactants.
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Fibromyalgia: The elephant in the Room
FatigueCognitive
Nervepain
Dry eyes and dry mouth
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As rheumatologists
• We will need to learn a new vocabulary about the perception of pain and how it is modulated by cytokines.
• The key term is the “plasticity” of the nervous system. How the perception of pain is modulated by cytokines of the “stress axis.”
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0
Neuroplasticity in Pain Processing1-3
1. Woolf CJ, Salter MW. Science. 2000;288:1765-1768. 2. Basbaum AI, Jessell TM. The perception of pain. In: Kandel ER, et al, eds.
Principles of Neural Science. 4th ed. 2000:479.3. Cervero F, Laird JMA. Pain. 1996;68:13-23.
Stimulus Intensity
100
Pain state Normal
Allodynia
Hyperalgesia3
80
60
40
20
innocuous noxious
Pai
n S
ensa
tio
n
Cytokines alter pain perception
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The Pain Roadmap: Peripheral and Central Nervous System Landmarks
Brain image courtesy of ATI
Peripheral Nervous System
Central Nervous System
• The neural processing of pain involves the:
– peripheral nervous system
– spinal cord (central nervous system)
– brain (central nervous system)
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Brain Regions that May Modulate Pain and Emotion1-4
Prefrontal Cortex
Hippocampus
Insular Cortex
Thalamus
Somatosensory Cortex
Both
Pain
Central Amplification of Pain from Eyes and Mouth: Regions Found on Functional MRI
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Thank you
for your time and attention I would be happy to entertain any questions
now or later.
The slides are available to you
for your use
at
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The Body’s 2 Distinct But Interconnected Immune Systems
ACQUIRED
Lymphyocytes (Type 2 interferon signature)
Beutler B et al. Blood Cells Mol Dis. 1998;24:216-230.
HLA-DR4–dependent:
T cells respond to peptide
antigens and generate
memory cells
INNATE
Dendritic Cells(Type 1 interferon signature)
HLA-DR–independent:
Dendritic cells respond to specific structures found on bacteria and apoptotic
Products (Toll receptors)