Microscopic MRI - UT Health San...
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Microscopic MRI Spatial resolution is limited by T2 decay Diffusion Susceptibility artifacts SNR FOV (gradient strength)
Transcript of Microscopic MRI - UT Health San...
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Microscopic MRI
Spatial resolution is limited by T2 decay Diffusion Susceptibility artifacts SNR FOV (gradient strength)
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Microscopic MRI
Signal recovery Increase B0 Optimizing RF coil 3D imaging Fast imaging
Bottom line: 2µm resolution at 14.1 T (geranium leaf stem)
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Microscopic MRI of nervous system
Cell lineage tracing using MRI contrast enhancement agent by microinjection
Agent should have good signal Physiologically inert be membrane impermeable
DTPA-Gd bound to dextran
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Microscopic MRI of nervous system
Histology MRI overlay
MRI of frog embryo
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Mapping two cell lines
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X laevis tadpole
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Mouse neonate
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In vivo and in utero!
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Manganese Enhanced MRI (MEMRI)
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