Microneedle patch technology for long-acting...

Microneedle patch technology for long-acting contraception

Mark R. Prausnitz Georgia Institute of Technology

© Mark Prausnitz, Georgia Tech .

Disclosure

Mark Prausnitz is a co-founder and has a significant financial interest in Micron Biomedical. This conflict of interest is managed by the Georgia Institute of Technolgy.

© Mark Prausnitz, Georgia Tech

Introduction to microneedle patches

Long-acting contraception

Outline


Microneedle patch ©

Mark Prausnitz, G

eorgia Tech

Microneedle patch


Microneedle patch meets public health needs

Patient administration Minimally-trained personnel No applicator, no reconstitution Painless delivery, no fear of needle

Manufacturing Low-cost, scalable fabrication

Transportation and storage Small package size Improved thermostability

Waste disposal No sharps waste Difficult or impossible reuse © Mark Prausnitz, Georgia Tech

Microneedle clinical trials

Microneedle patch vaccination

• Influenza vaccine o Phase 1 (Lancet 2017)

• Measles-rubella vaccine o Phase 1 (summer 2020)

• Others, Phase 1 and 2 o (2020, 2021)

© M

ark Prausnitz, Georgia Tech

Outline

Long-acting contraception

This abstract is made possible by the generous support of the American people through USAID, provided to FHI 360 through cooperative agreement number AID-OAA-A-15-00045. The contents of this abstract are the responsibility of the authors and do not reflect the views of the U.S. Agency for International Development (USAID) or the United States Government.

© M


Need for long-acting contraception

Provide increased access to family planning resources

Every year there are

• 212 million pregnancies

• 56 million (27%) abortions

• 85 million (40%) pregnancies unintended


Design of separable microneedle patch for long-acting contraception

B

skin

microneedle patch

A

release layer


Separable microneedles for long-acting contraception

fluid from skin Goal:

Approach: water-soluble air bubble effervescent

material © Mark Prausnitz, Georgia Tech

Design and fabrication of rapidly separable MNPs

Wei Li et al., Nature Biomedical Engineering, 2019 © Mark Prausnitz, Georgia Tech

Incorporation of bubble in rapidly separable MNPs


Mechanical performance of rapidly separable MNPs


Application of MNPs to porcine skin ex vivo

Wei Li et al., Nature Biomedical Engineering, 2019

© M


Histological image of MNs in porcine skin ex vivo


Release kinetics of LNG from MNPs

Wei Li et al., Nature Biomedical Engineering, 2019 LNG = levonorgestrel

© M


Imaging of dye release from MNPs in rats


© M


Release of LNG from MNPs in rats


LNG = levonorgestrel


Wei Li et al., Scientific Reports, 2019

Design and fabrication of rapidly separable effervescent MNPs


Pharmacokinetics of LNG from MNPs in rats


Tolerability of placebo effervescent patch in humans (n = 10)


Preferences of human participants (n = 10)

Wei Li et al., Scientific Reports, 2019

Monthly patch vs. monthly injection Monthly patch vs. daily pill


Microneedle patch with larger dose

Microneedle patch with longer-acting contraception

Future work


Microneedle patch technology for long-acting...

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