Dissolving Microneedle PatchAnti-Wrinkle Science

Dissolving microneedle

Nobel Smart Patch

► Painless

► Bloodless

► Dose & Time – Easy Controlled System

Dissolution after microneedle penetrates dermis

Dissolving form after penetrating human skin / SEM Image

▪ Next generation transdermal drug delivery system (microneedle TDS system)

+ Microneedle Fabrication + Bio degradable polymers + Drug Delivery System

▪ World's first patented dissolvable cosmetic dermal patch directly delivers

cosmetic components to the epidermis of the skin without causing skin

damage or pain (US Pat #6,945,952 #7,182,747, #7,211,062)

▪ The revolutionary dissolvable micro needle can be used for various

dermatologic purposes in beauty and therapeutic care.

Benefits of microneedle

MICRONEEDLE ARRAY

Effortless and painless

Precise control of

penetration depth

Direct and

controlled delivery

Ability to manipulate

The drug formulation;

suspension, powder,..

Patient self-administration

Fast Dissolving

A

B

C

D

PharmaceuticalsBeauty Care

Beauty ClinicImmuno-cell therapy

▪Anti -wrinkle

▪ Whitening & Anti-pigmentation

(dark circles, age spots, freckles)

▪Anti-hair loss

Skin trouble

▪Anti-acne

▪Alopecia area treatment

▪ Botox patch

▪ Flu vaccine

▪Arthritis cure

Langerhans cells in dermis

▪ Insulin patch

▪ Growth hormone patch

▪ PTH patch (osteoporosis)

▪ EPO

▪ Fentanyl patch (pain-killer)

Application of microneedle

Anti-wrinkle microneedle patch

Backing film

Protect Cover

Microneedle disk (Green part)

Patch structure & Materials

250 μm

▪ Product: KEY-265 De-Aging Patch (Wrinkle Improver)

► Patching duration: Approximately 10~15 minutes (rapid dissolution after skin penetration)

▪ Structure of microneedle

► Length of microneedle(3types) : 250㎛ / 200 ㎛ / 150 ㎛ → Selective penetration of stratum corneum and epidermis

► Microneedle materials

① for mechanical structure and dissolution : Na-CMC, Sucrose, Trehalose, Collagen, etc.

② Wrinkle-improving Ingredients : Adenosine, vitamin C, EGF, biopeptide (CTP, AHP, PPP)

▪ Patch type : Circular type, Eye line type, Square type (Disk weight : 0.04g~0.05g)

Benefits

► The dissolvable microneedle, It’s revolutionary transdermal delivery systems to

replace fearful injection and needles with a patch that can be painlessly and simply

applied by a patient. ( Botox injection ► Botox Patch )

► This world’s first patented microneedle path directly delivers cosmetic ingredients to the

inner skin, which is enhancing the absorption and penetration of active ingredients

dramatically than normal skin care.

( penetration & absorption : KEY265 ► 100% >>> normal skin care ► 0.3%)

► Excellent safety

No adverse skin reaction, No skin irritation, Germ free, Not re-use(safe disposal )

Smart Patch

Anti-wrinkle Line

Product Line Sets

Anti-wrinkle patch (15/20pairs/pack) Ample (10ml x 3ea) Serum (40ml) Cream (40ml) Eye cream (15ml)

▪ Anti-wrinkle line (4kinds) : Ample (10ml), Serum (40ml), Cream (40ml), Eye cream (15ml) ► Certified for wrinkle improvement by KFDA

+ Brand : ‘xxxxx’( ref. Ample ► ‘xxxxx Renutrive ample’ )

▪ Key ingredients

①Ample ► freeze drying powder (Growth factor complex) + Solution (Peptide complex + Adenosine + Others)

- Growth factor complex powder : EGF, bFGF, KGF-2, IGF-1, SOD1

② Serum – Eye cream – Cream

- Growth factor complex : EGF-bFGF-KGF-IGF-SOD - Peptide complex : CTP – AHP – PPP – KVARP

▪ Safety : No chemical preservative (paraben), No chemical fragrance, No chemical surfactant ► Dr. Brand concept

▪ Benefits : Certified for Wrinkle Improvement by KFDA , Firming, Cellular repair, More Elasticity, Even skin tone, Moisturizing

Hi-Tech

(DR. & Global brand)Hi-Touch

Natural+Eco-phil

Transdermal Delivery

System Design & Brand

Clinic test for anti-wrinkle improvement

Anti-Wrinkle Improvement

0 Week 4 Week 8 Week

Digital

image

3D

image

Deral

image

0

2

4

6

8

10

12

0 week 4 week 8 week

%

Anti-wrinkle improvement [Ra]

* Improvement = 20.5%

▣ Clinic test on human skin ; Evaluation of skin wrinkle, elasticity and dermal density of KEY265 (dis-solvable microneedle patch)

► Clinic center : Dermapro / Skin Research Center Test Period April 25 ~ July 21 Numbers : 20 women (aver aged 44.7 yrs)

[ Statistical analysis of Ra wrinkle parameter on crow’s foot ]

Fine line wrinkles(Ra) were significantly decreased at 4

and 8weeks compare to before treatment.

* Decrement value represents improvement of skin wrinkle

Parameter Week N Mean(μm) SD SEM Decrement(%)

Ra

0W 20 15.18 2.31 0.52 -

4W 20 13.73 2.12 0.47 9.55 ▼

8W 20 13.09 2.12 0.47 13.77 ▼

8

Human clinic

#06 #08 #09 #10 #12

0W

4W

8W

8.5% 14.6% 21.8% 20.5% 26.9%Improve

-ment

Clinic test for anti-wrinkle improvement

Manufacturing Process

Mixing Dispensing

Cosmetic rawmaterial

Biopolymers

De-air

AgingMolding Drying Patching Packaging

Inspection of raw materials

Confidential

Silicon

molding

▪ Press molding

Dispenser ▪ Molding (centrifuge)

▪ Drying chamber

▪ Coating

▪ Laminating

▪ Cutting

▪ Assembly

▪ packagingHomogenizer Mixer

+ API

+ Biopolymer

+ Additives

Thanks

For question or inquiry of sample and trial order

E-mail: kwon.hb@gmail.com / andy.mylee@gmail.com

Phone: +82-505-288-0011

WhatsApp: +82-10-8557-3292 / +82-10-5474-9905