MEPCO SCHLENK ENGINEERING COLLEGE, …. 15MB203 Immunotechnology 30 ... Current Good Manufacturing...

41

MEPCO SCHLENK ENGINEERING COLLEGE, SIVAKASI

(AUTONOMOUS)

AFFILIATED TO ANNA UNIVERSITY, CHENNAI 600 025

REGULATIONS: MEPCO - R2015 (FULL TIME)

M.TECH. BIOTECHNOLOGY

Department Vision

Impart strong theoretical background in the fundamental

concepts of Biology and Chemical Engineering.

Train students to be methodical and systematic to pursue

laboratory experiments with utmost care and purpose.

Expose students to modern tools of Biotechnology research.

Department Mission

To enable students to acquire specialized skills in core aspects

of engineering and life sciences and apply them for the

development of innovative technologies.

To transform the department into a full-fledged research facility

by developing modern infrastructure to pursue research in cutting

edge areas of Biotechnology.

To train students to realize enormous responsibility of being a

biotechnologist to serve society taking cognizance of ethical and

environmental responsibilities.

41

Programme Educational Objectives

Acquire knowledge with an objective of developing innovative

technologies.

Attain intellectual independence to be a successful leader,

technocrat, teacher and scientist.

Acquire an ability to remain self-motivated to be a successful team

player.

Remain positive, proactive and patient to understand intricacies of

Biotechnology for problem solving.

Programme Outcomes

Acquiring skills, knowledge and core competence in the cutting edge

areas of Biotechnology.

Attain intellectual agility for logical reasoning in problem solving.

Ability to articulate debate and analyze scientific problems with clarity.

Understand and exercise social responsibility of being a

Biotechnologist.

Behave to be a thorough professional by practicing ethical standards

of Biotechnology.

Develop passion towards research and development by identifying

core area of interest.

Ability to focus on minuteness, accuracy and precision while

performing laboratory experiments.

Maintain integrity in performing, practicing and administering science

and technology.

42

CURRICULUM (I TO IV SEMESTER)

SEMESTER I

SL. NO.

COURSE CODE

COURSE TITLE L T P C

THEORY

1. 15MA178 Applied Statistics for Biotechnologists

3 2 0 4

2. 15MB101 Bioprocess Technology 3 0 0 3

3. 15MB102 Computational Biology 2 2 0 3

4. 15MB103 Entrepreneurship, IPR and Biosafety

3 0 0 3

5. Core Elective I 3 0 0 3

6. Core Elective II 3 0 0 3

7. Core Elective III 3 0 0 3

PRACTICAL

8. 15MB151 Preparative and Analytical Techniques in Biotechnology

0 0 6 3

TOTAL 20 4 6 25

SEMESTER II

SL. NO.

COURSE CODE


THEORY

1. 15MB201 Bioseparation Technology 3 0 0 3

2. 15MB202 Advanced Genetic Engineering 3 0 0 3

3. 15MB203 Immunotechnology 3 0 0 3

4. 15MB204 Animal Biotechnology 3 0 0 3

5. Core Elective IV 3 0 0 3

6. Allied Elective 3 0 0 3

7. Open Elective 3 0 0 3

PRACTICAL

8. 15MB251 Microbial and Immuno Technology Lab

0 0 6 3

TOTAL 21 0 6 24

43

SEMESTER III

SL.NO. COURSE

CODE COURSE TITLE L T P C

PRACTICAL

1. 15MB351 Project Work (Phase I) 0 0 12 6

2. 15MB352 Advanced Molecular Biology and

Genetic Engineering Laboratory 0 0 6 3

3. 15MB353

Advanced Bioprocess and

Downstream Processing

Laboratory

0 0 6 3

TOTAL 0 0 24 12

SEMESTER IV

SL.NO. COURSE CODE


PRACTICAL

1. 15MB451 Project Work (Phase II) 0 0 24 12

TOTAL 0 0 24 12

Total No. of Credits: 73

LIST OF CORE ELECTIVES

SL.NO. COURSE


1. 15MBC01 Biocatalyst and Enzyme Technology

3 0 0 3

2. 15MBC02 Food Processing and Biotechnology 3 0 0 3

3. 15MBC03 Pharmaceutical Biotechnology 3 0 0 3

4. 15MBC04 Environmental Biotechnology 3 0 0 3

5. 15MBC05 Computer Aided Learning of Structure and Function of Proteins

3 0 0 3

44

SL.NO. COURSE


6. 15MBC06 Metabolic Process and Engineering 3 0 0 3

7. 15MBC07 Bioprocess Modeling and Simulation

3 0 0 3

8. 15MBC08 Plant Biotechnology 3 0 0 3

9. 15MBC09 Plant Design and Practice 3 0 0 3

10. 15MBC10 Clinical Trials and Bioethics 3 0 0 3

11. 15MBC11 Advances in Molecular Pathogenesis

3 0 0 3

12. 15MBC12

Nanotechnology applications in Biology

3 0 0 3

13. 15MBC13

Research Methodology in Biotechnology

3 0 0 3

14. 15MBC14

Sensors and Instrumentation for Bioapplications

3 0 0 3

15. 15MBC15 Biofuels and Platform Chemicals 3 0 0 3

16. 15MBC16 Genomics and Transcriptomics 3 0 0 3

17. 15MBC17 Proteomics and Mass Spectroscopy 3 0 0 3

18. 15MBC18

Computational Techniques in Bioprocess

3 0 0 3

19. 15MBC19

Advanced Technologies In Omics Sciences

3 0 0 3

20. 15MBC20

Tissue Engineering and Regenerative Medicine

3 0 0 3

45

LIST OF SPECIAL COURSES

SL. NO.

COURSE CODE


THEORY

1. 15BTS01 Industrial training in Bioprocess

Engineering 1 0 0 1

2. 15BTS02 Current Good Manufacturing Practices

1 0 0 1

46

I SEMESTER

15MA178 APPLIED STATISTICS FOR BIOTECHNOLOGISTS L T P C

3 2 0 4

Course Objectives:

To review the basic concepts of probability and apply in a real life

situations.

To give the applications of probability distributions.

To understand the concept of association between variables applicable

in biological data.

To provide information about testing of hypothesis and design of

experiment regarding biostatistics.

Course Outcomes:

At the end of the course, the students will be able to

Explain the basic concepts of probability and its application.

Apply probability distributions in their field.

Use statistical techniques for analyzing biological data.

Apply the hypothesis test and design of experiment regarding

biostatistics.

UNIT I PROBABILITY & RANDOM VARIABLES 12

Sample spaces – Events - Axiomatic approach to probability - conditional

probability - addition theorem - Multiplication theorem - Random variables -

discrete and continuous - Distribution function - Expectation with properties –

Moments – Mean - Variance.

UNIT II STANDARD DISTRIBUTIONS 12

Discrete distribution - Binomial, Poisson and Geometric distribution -

Continuous distribution - Exponential, Gamma and Normal distribution –

simple properties - Bivariate distribution - conditional and marginal

distribution

47

UNIT III CORRELATION, REGRESSION & CURVE FITTING 12

Correlation coefficient – Properties - Rank correlation - Regression

equations - curve fitting by the method of least squares - fitting curves of the

form ax+b, ax2+bx+c, abx and axb - Bivariate correlation application to

biotechnologists.

UNIT IV TESTING OF HYPOTHESIS 12

Concept of sampling - Methods of sampling - sampling distributions and

Standard Error - Small samples and large samples - Test of hypothesis -

Type I, Type II Errors - Critical region - Large sample tests for proportion and

mean - Exact test based on normal, t, f and chi-square distribution -Test of

goodness of fit.

UNIT V DESIGN OF EXPERIMENTS 12

Basic principles of experimentation - Analysis of variance – one-way,

Two-way classifications - Randomized block design and Latin square design.

TOTAL: 60 PERIODS

REFERENCE BOOKS:

1. Kapoor, V. C. “Fundamentals of Mathematical Statistics”. S. Chand &

Sons.11th Edition, 2013.

2. Vittal, P.R. and V.Malini.”Statistical and Numerical Methods”. Margam

Publications, 1st Edition, Chennai.

3. Veerarajan,T. “Probability, Statistics and Random Processes”.3rd

Edition., Tata McGraw-Hill, 2008.

4. Johnson, R. A., “Miller & Freund’s Probability and Statistics for

Engineers”. PHI, 6th Edition, 2003.

5. Arora, P. N. Smeet Arora, and Arora, S. “Comprehensive Statistical

Methods”. S. Chand & Co, 2nd Edition, 2007.

6. Spiegel, Murray R., Schiller J and R. Alu Srinivasan.”Schaum’s Outlines

Probability and Statistics”, Tata McGraw-Hill, 2nd Edition, 2000.

7. Kandasamy, P. K. Thilagavathi & K. Gunavathi. “Probability Statistics

and Queuing Theory”. S. Chand & Co., 2004

48

15MB101 BIOPROCESS TECHNOLOGY L T P C

3 0 0 3

Course Objectives:

Acquire knowledge about the stoichiometric balances in a production

To study and analyze parameters involved in the modeling of various

fermentation process.

To understand about the parameters and design of the fermentation

process.

To understand the design and construction of bioreactors

To have an overview about the processes involved in the

fermentation for product development.

Course Outcomes:

Able to know about the elemental balance, heat balance and black

box stochiometries involved in bioprocess

Able to model various fermentation processes.

Able to design and construct bioreactor based on process and

production strategy

Able to know about the important parameters involved in designing

the fermentation process.

Able to design and optimize the fermentation process to increase the

production.

UNIT I BLACK BOX MODEL 9

Yield coefficients, black box stoichiometries, elemental balances, heat

balance, degrees of reduction balances, systematic analysis of black box

stoichiometries, identification of gross measurement errors.

UNIT II MODELING OF VARIOUS FERMENTATION

PROCESSES

9

49

Principles of model building for biotechnological processes, unstructured

models on the population level, structured models on the cellular level,

morphologically structured model, genetically structured models, cybernetic

model, modeling of recombinant systems.

UNIT III DESIGN OF FERMENTATION PROCESSES 9

Kinetics of substrate utilization, biomass growth and product formation,

inhibition of cell growth and product formation. Design and operation of

continuous cultures, chemostat in series, batch and fed batch cultures, total

cell retention cultivation.

UNIT IV BIOREACTOR DESIGN & CONSTRUCTION 9

Basic design and construction of CSTR, bioreactor design of agitator /

agitator motor, power consumption in aerated bioreactor, design of sparger,

mixing time estimation, oxygen mass transfer capability in bioreactor,

Removal of Heat in bioreactor, Main parameters to be monitored and

controlled in fermentation processes.

UNIT V CASE STUDIES IN FERMENTATION DERIVED

PRODUCTS

9

Case studies on Production of green chemicals, algal biofuels, recombinant

Insulin. Case studies should deal with medium design, reactor design &

process optimization etc.,

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Shuler, M.L., Kargi F., “Bioprocess Engineering “, Prentice Hall, 2nd

Edition, 2002.

2. Pauline D., “Bioprocess Engineering Principles “. Elsevier, 2nd Edition,

2012.

3. Nielsen, J. and Villadsen, J. “Bioreaction Engineering Principles”.

Springer, 2nd Edition, 2007.

50

4. Blanch H.W., Clark D. S., “Biochemical Engineering”, Marcel Dekker,

Inc. 2nd Edition, 1997.

5. Bailey, J.E. and Ollis, D.F. “Biochemical Engineering Fundamentals",

McGraw Hill, 2nd Edition, 1986.

6. Lydersen B.K., “Bioprocess Engineering Systems, Equipment and

Facilities”, Wiley-Blackwell, 1st Edition, 1994.

7. Bailey, J.E. and Ollis, D.F. “Biochemical Engineering Fundamentals",

2nd Edition, McGraw Hill, 1986.

8. Stanbury, P.F., Stephen J.H., Whitaker A., “Principles of Fermentation

Technology”, Science & Technology Books, 2nd Edition, 2009.

15MB102 COMPUTATIONAL BIOLOGY L T P C

2 2 0 3

Course Objectives:

To acquire basic knowledge about accessing the database

information and alignment of sequences for comparison through

various algorithms.

To understand about the phylogenetics and phylogenetic tree

construction.

To understand about the modeling and docking of proteins.

To know about machine learning techniques and microarray data

analysis.

To acquire knowledge about perl programming.

Course Outcomes:

Able to understand the types of databases.

Able to retrieve the biological information from the databases

Able to construct phylogenetic tree.

Able to predict the protein structure and understand about the

docking applications

Able to code for various programs through perl programming.

51

UNIT I INTRODUCTION TO COMPUTATIONAL BIOLOGY

AND SEQUENCE ANALYSIS

9

Molecular sequences, Genome sequencing: pipeline and data, Next

generation sequencing data, Biological databases: Protein and Nucleotide

databases, Sequence Alignment, Dynamic Programming for computing edit

distance and string similarity, Local and Global Alignment, Needleman

Wunsch Algorithm, Smith Waterman Algorithm, BLAST family of programs,

FASTA algorithm, Functional Annotation, Progressive and Iterative Methods

for Multiple sequence alignment, Applications.

UNIT II PHYLOGENETICS 7

Introduction to Phylogenetics, Distance and Character based methods for

phylogenetic tree construction: UPGMA, Neighbour joining, Ultrametric and

Min ultrametric trees, Parsimonous trees, Additive trees, Bootstrapping.

UNIT III PROTEIN STRUCTURE, MODELLING AND

SIMULATIONS

9

Protein Structure Basics, Visualization, Prediction of Secondary Structure

and Tertiary Structure, Homology Modeling, Structural Genomics, Molecular

Docking principles and applications, Molecular dynamics simulations.

UNIT IV MACHINE LEARNING, SYSTEMS BIOLOGY AND

OTHER ADVANCED TOPICS

11

Machine learning techniques: Artificial Neural Networks and Hidden Markov

Models: Applications in Protein Secondary Structure Prediction and Gene

Finding, Introduction to Systems Biology and its applications in whole cell

modeling, Microarrays and Clustering techniques for microarray data

analysis, informatics in Genomics and Proteomics, DNA computing.

UNIT V PERL FOR BIOINFORMATICS 9

Variables, Data types, control flow constructs, Pattern Matching, String

52

manipulation, arrays, lists and hashes, File handling, Programs to handle

biological data and parse output files for interpretation

Laboratory Demonstrations for:

Biological Databases, Sequence alignment: BLAST family of programs,

FASTA, ClustalW for multiple sequence alignment, Phylogenetics software,

Homology Modeling and Model evaluation, AutoDock, GROMACS,

Prokaryotic and Eukaryotic Gene finding software, Programs in PERL.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Gusfield D. et al., “Algorithms on Strings Trees and Sequences.”

Cambridge University Press, 1st Edition, 1997.

2. Mount, David W. “Bioinformatics: Sequence and Genome Analysis”,

CBS, 2nd Edition 2004.

3. Lesk, Arthur M., “Introduction to Bioinformatics”, Oxford University Press,

2nd Edition. 2010.

4. James T., “Beginning PERL for Bioinformatics”, O’Reilley Publications,

1st Edition, 2001.

5. Leach A. R., “Molecular Modeling Principles and Applications”, Pearson,

2nd Edition, 2010.

6. Baldi P., Brunak S., “Bioinformatics: The Machine Learning Approach.”

East West Press, 2nd Edition, 2003

7. Baxevanis A.D., Oullette, B.F.F., A Practical Guide to the Analysis of

Genes and Proteins” John Wiley, 2nd Edition, 2002.

8. Durbin R. Eddy S., Krogh A., Mitchison G., “Biological Sequence

Analysis: Probabilistic Models of Proteins and Nucleic Acids”, Cambridge

University Press, 1st Edition, 1998.

9. Pennington S.R., Dunn M.J., “Proteomics from Protein Sequence to

Function”, Taylor and Francis, 2nd Edition, 2000.

53

15MB103 ENTREPRENEURSHIP, IPR AND BIOSAFETY L T P C

3 0 0 3

Course Objectives:

To introduce the concepts of entrepreneurship in a modern

biotechnology industry.

To introduce concepts of intellectual property in a modern biotechnology

industry.

To acquire knowledge about the types of patents and patent search

through databases.

To acquire knowledge about the procedure for patent filing and patent

infringement cases.

To introduce the concepts and importance of biosafety in a modern

biotechnology industry.

Course Outcomes:

The course will motivate students to become entrepreneurs, spearhead

development of the biotech industry at the same time they will

appreciate the need to protect intellectual property rights. They will also

recognize the importance of biosafety in the laboratory.

Able to know about the requirements of entrepreneur and kinds of

entrepreneur

Able understand about the types of intellectual property and laws for

protecting intellectual property.

Able to search the patent databases and know about the patents.

Able to file the patents and know about the patenting procedures.

Able to know about the levels of biosafety and their importance.

UNIT I ENTREPRENEURSHIP 10

Definition. Functions and kinds of entrepreneurs. Entrepreneurship and

economic development, Entrepreneurial competencies and traits,

developing competencies. Project identification, selection and financing.

Project report- content and significance, Planning Commission’s guidelines

for formulating project reports-methods of project appraisals.

54

UNIT II INTRODUCTION TO INTELLECTUAL PROPERTY 10

Types of Intellectual property (IP): Patents, Trademarks, Copyright &

Related Rights, Industrial Design, Traditional Knowledge, Geographical

Indications, Protection of GMOs IP as a factor in R&D; IPs of relevance to

Biotechnology Agreements and Treaties. History of GATT & TRIPS

Agreement; Madrid Agreement; Hague Agreement; WIPO Treaties;

Budapest Treaty; PCT; Indian Patent Act 1970 & recent amendments; Case

studies.

UNIT III BASICS OF PATENTS AND CONCEPT OF

PRIOR ART

8

Introduction to Patents; Types of patent applications: Ordinary, PCT,

Conventional, Divisional and Patent of Addition; Specifications: Provisional

and complete; Forms and fees Invention in context of “prior art”; Patent

databases; Searching International Databases; Country-wise patent

searches (USPTO, esp@cenet, EPO), PATENT Scope (WIPO), IPO, etc.).

UNIT IV PATENTING PROCEDURES 7

National & PCT filing procedure; Time frame and cost; Status of the patent

applications filed; Precautions while patenting – disclosure/non-disclosure;

Financial assistance for patenting - introduction to existing schemes Patent

licensing and agreement Patent infringement- meaning, scope, litigation,

case studies.

UNIT V BIOSAFETY 10

Introduction; Historical Background; Introduction to Biological Safety

Cabinets; Primary Containment for Biohazards; Biosafety Levels; Biosafety

Levels of Specific Microorganisms; Recommended Biosafety Levels for

Infectious Agents and Infected Animals; Biosafety guidelines - Government

of India; Definition of GMOs & LMOs; Roles of Institutional Biosafety

Committee, RCGM, GEAC etc. for GMO applications in food and

55

agriculture; Environmental release of GMOs; Risk Analysis; Risk

Assessment; Risk management and communication; Overview of National

Regulations and relevant International Agreements including Cartegana

Protocol.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. BAREACT, “Indian Patent Act 1970 Acts & Rules”, Universal Law

Publishing Co. Pvt. Ltd., 2007

2. Kankanala C., “Genetic Patent Law & Strategy.”, Manupatra Information

Solution Pvt. Ltd., 2007.

3. Kanka S.S., “Entrepreneurship Development”., S. Chand & Co., 1st

Edition, 1997.

4. Rajeev R., “Entrepreneurship”, Oxford University Press, 2nd Edition,

2011.

5. Ronald B.H., David A., “Patent Law: A Practitioner’s Guide”, Practising

Law Institute, 4th Edition, 2013.

6. Sateesh M.K., “Bioethics and Biosafety”, I.K. International Publishing

House Pvt. Ltd., 1st Edition, 2007.

15MB151 PREPARATIVE AND ANALYTICAL TECHNIQUES

IN BIOTECHNOLOGY

L T P C

0 0 6 3

Course Objectives:

To understand the techniques and equipment involved in analyzing the

biomolecules in Biotechnology.

To understand the estimation of the biomolecules based on different

methods.

To separate the biomolecules based on their characteristics.

To prepare the components required for the techniques of separation

and estimation of biomolecules.

56

To acquire hands-on experience using the equipment for the

separation and estimation of biomolecules.

Course Outcomes:

Able to analyze the biomolecules based on their specific features.

Able to prepare the buffers required for analyzing and separating the

biomolecules.

Able to separate the biomolecules based on chromatography.

Able to estimate the protein, DNA and carbohydrates quantitatively.

SYLLABUS FOR THE LAB:

1. Preparation of Acetate, Tris and Phosphate Buffer systems and

validation of Henderson-Hasselbach equation.

2. Reactions of amino acids – Ninhydrin, Pthaldehyde, Dansyl chloride –

measurement using colorimetric and fluorimetric methods.

3. Differential estimations of carbohydrates – reducing vs non-reducing,

polymeric vs oligomeric, hexose vs. pentose

4. Estimation of protein concentration using Lowrys’ method, Dye-

binding method

5. DNA determination by UV-Vis spectrophotometer – hyperchromic

effect

6. Separation of lipids by TLC.

7. Enzyme Kinetics: Direct and indirect assays – determination of Km,

Vmax and Kcat, Kcat/ Km

8. Iso electric Focusing: Application in 2D gel using known or unknown

protein

9. Gradient fractionation of macromolecules using ultracentrifugation

10. Agarose gel electrophoresis: Determination of molecular weight of

restricted DNA

11. Electroporation in E. coli and Yeast

12. Preservation of microorganism; Freeze Drying

TOTAL: 78 PERIODS

57

REFERENCE BOOKS:

1. Segel, Irwin H. “Biochemical Calculations: How to Solve Mathematical

Problems in General Biochemistry.”, John Wiley & Sons, 2nd Edition.

1976.

2. Wilson, Keith and J. Walker “Principles and Techniques of Practical

Biochemistry and Molecular Biology”, Cambridge University Press, 6th

Edition. 2006.

3. Alfred P., Claus U., Jim H., Albert J., “Biochemical Methods: A Concise

Guide for Students and Researchers”, Wiley VCH, 1st Edition, 2008.

II SEMESTER

15MB201 BIOSEPARATION TECHNOLOGY L T P C

3 0 0 3

Course Objectives:

To learn the bioseparation methods used in downstream processing of

bioproducts.

To learn about the cell disruption and solid-liquid separation techniques

in downstream process.

Acquire knowledge about the techniques involved in concentration and

purification of products.

To learn the purification of biomolecules using chromatography

To know about downstream process economics and final polishing of

products.

Course Outcomes:

Able to critically analyze the biochemical characteristics of the

bioproducts and choose strategy for their purification.

Able to choose the unit operations to separate insolubles from

fermentation broth.

Able to purify biomolecules through chromatography and understand the

complexity in scale up of unit operations.

58

Able to choose the downstream steps within the constraints of biosafety

and process economics.

Able to polish the bioproducts through various techniques

UNIT I INTRODUCTION TO BIOSEPARATION 4

Characterization of biomolecules and fermentation broth. Guidelines to

recombinant protein purification.

UNIT II SOLID-LIQUID SEPARATION AND CELL

DISRUPTION

6

Solid liquid separation- microfiltration and centrifugation – theory and design

for scale up operation. Cell disruption – Homogenizer, dyno mill – principle,

factors affecting disruption, batch and continuous operation. Cell disruption

by chemical methods.

UNIT III CONCENTRATION AND PURIFICATION 7

Liquid- liquid extraction – theory and practice with emphasis on Aqueous two

phase extraction. Solid liquid extraction. Precipitation techniques using salt

and solvent. Separation by ultrafiltration, Dialysis, Electrophoresis.

UNIT IV CHROMATOGRAPHY 15

Theory, practice and selection of media for– Gel filtration chromatography,

Ion exchange chromatography, Hydrophobic interaction chromatography,

reverse phase chromatography, Affinity chromatography – Metal affinity

chromatography, dye affinity chromatography, immunosorbent affinity

chromatography & Expanded bed chromatography. Scale up criteria for

chromatography, calculation of no of theoretical plates and design.

UNIT V FINAL POLISHING AND CASE STUDIES 13

Drying, spray drying and crystallization. Purification of cephalosporin,

aspartic acid, Recombinant Streptokinase, Monoclonal antibodies, Tissue

plasminogen activator, Taq polymerase, Insulin.

59

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Belter P.A., Cussler E.L., Houhu W., “Bioseparations: Downstream

Processing for Biotechnology”, Wiley Interscience Publications, 1st

Edition, 1988.

2. Ghosh R., “Principles of Bioseparations Engineering.” World Scientific

Co. Ltd., 1st Edition, 2006.

3. Sivasankar B., “Bioseparations: Principles and Techniques.” PHI, 1st

Edition, 2005.

4. Janson J.C., “Protein Purification– Principles, High Resolution

Methods and Applications”, Wiley Blackwell, 3rd Edition, 1989

5. Scopes R.K., “Protein Purification – Principles and Practice”, Narosa

Publication, 3rd Edition, 1994.

6. Asenjo J.M., “Separation processes in Biotechnology” CRC Press, 1st

Edition, 1990.

15MB202 ADVANCED GENETIC ENGINEERING L T P C

3 0 0 3

Course Objectives:

The course imparts knowledge about cloning and expression vectors.

Emphasize about DNA library construction

Emphasize about the sequencing techniques.

Emphasize about amplification and mutagenesis methods.

The course focuses on transgenic science for genetic improvement of

crops and animals.

Course Outcomes:

Understand the applications of restriction mapping and markers.

Students familiarize in gene cloning and role of expression vectors in

enhancing expression of recombinant protein.

60

Descriptive knowledge about regulation in gene expression, amplification

and sequencing of genetic material.

Descriptive knowledge about amplification of genetic material.

Have a broad perspective on gene therapy in health care.

UNIT I CLONING AND EXPRESSION OF GENES 10

Overview of Restriction and Modification system. Cloning vehicles: Plasmids

– Host range, Copy number control, Compatibility. λ phage – Insertional and

replacement vectors, in vitro packaging. Single strand DNA vector – M13

Phage. Cosmids, Phasmids, PAC, BAC and YAC. Expression vector –

Characteristics, RNA probe synthesis, High level expression of proteins,

Protein solubilization, purification and export.

UNIT II CONSTRUCTION OF DNA LIBRARIES 10

DNA library – types and importance. cDNA library: Conventional cloning

strategies – OligodT priming, self-priming and its limitations. Full length

cDNA cloning – CAPture method and Oligo capping. Strategies for gDNA

library construction – Chromosome walking. gDNA and cDNA library.

Screening strategy. Hybridization, PCR, Immunoscreening, South-Western

and North-Western. Functional cloning – Functional complementation and

gain of function. Difference cloning: Differential screening, Subtracted DNA

library, differential display by PCR. Microarrays. Applications of microarrays.

UNIT III DNA SEQUENCING 8

DNA sequencing. Chemical and Enzymatic methods, Pyrosequencing,

Automated sequencing, Genome sequencing methods – top -down

approach, bottom- up approach.

UNIT IV PCR AND MUTAGENESIS 9

Polymerase Chain Reaction (PCR).Principle and applications. Different types

of PCR - Hot start PCR, Touchdown PCR, Multiplex PCR, Inverse PCR,

Nested PCR, AFLP-PCR, Allele specific PCR, Assembly PCR, Asymmetric

61

PCR, LATE-PCR, Colony PCR, in situ PCR, Long PCR. Real-time PCR,

FRET, SYBR Green assay, Taqman Probes, Molecular beacons.

Mutagenesis and chimeric protein engineering by PCR, RACE, Kunkels’

method of mutagenesis, Phage display and screening methodologies.

UNIT V GENE TRANSFER AND GENE THERAPY 8

Introduction of foreign genes into animal cells – Importance, DNA

Microinjection, Retroviral vectors, Trasnsfection of Embryonic stem cells,

recombination. Transgenic plants – Importance, Ti Plasmid, Co integrate and

Binary vectors. Gene therapy- An Overview

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Primrose S.B., Twyman R.H., Old R.W. “Principles of Gene

Manipulation.” Blackwell Science/Oxford, 7th Edition, 2006

2. Winnacker E.L., “From Genes to Clones: Introduction to Gene

Technology.” Panima, 2nd Edition, 2003.

3. Glick B.R. and Pasternak J.J.” Molecular Biotechnology: Principles and

Applications of Recombinant DNA, ASM Press, 3rd Edition , 2003.

4. Lemonie N.R., Cooper D.N., “Gene Therapy.” Academic Press, 2nd

Edition, 1999.

62

15MB203 IMMUNOTECHNOLOGY L T P C

3 0 0 3

Course Objectives:

To learn physiology of organs in immune system and their functions

during immune response

To learn about the antibodies and their significance in diagnosis.

Emphasize the significance of immune responses and diagnostic

applications of immunological techniques.

To understand strategies involved in vaccine development, antibody

engineering and library construction.

To acquire deep knowledge in the field of immunotherapeutics.

Course Outcomes:

Able to understand the significance of immune system.

Able to understand the diagnostic applications of antibodies.

Formalize the methodology and applications of Immunological assays

Provide knowledge about vaccines.

Provide knowledge about antibody engineering.

UNIT I INTRODUCTION 12

Cells of the immune system and their development; primary and secondary

lymphoid organs; humoral immune response; cell mediated immune

responses; complement, Allergy and hypersensitivity.

UNIT II ANTIBODIES 10

Monoclonal antibodies and their use in diagnostics; ELISA; Agglutination

tests; Antigen detection assay; Plaque Forming Cell Assay.

UNIT III CELLULAR IMMUNOLOGY 12

PBMC separation from the blood; identification of lymphocytes based on CD

markers; FACS; Lymphoproliferation assay; Cytotoxicity assays; Mixed

63

lymphocyte reaction; Cr51 release assay; macrophage cultures; cytokine

bioassays- IL2, γ IFN, TNF α.; HLA typing.

UNIT IV VACCINE TECHNOLOGY 6

Basic principles of vaccine development; protein based vaccines; DNA

vaccines; Plant based vaccines; recombinant antigens as vaccines; reverse

vaccinology.

UNIT V DEVELOPMENT OF IMMUNOTHERAPEUTICS 5

Engineered antibodies; catalytic antibodies; idiotypic antibodies;

combinatorial libraries for antibody isolation.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. David M., “Immunology”, Mosby Publication, 7th Edition, 2007.

2. Kindt T.J. et al., “Immunology”, W.H. Freeman, 6th Edition, 2007.

3. Janeway C.A. etal., “Immunology : The Immuno Systems in Health and

Diseases”, Garland Science, 6th Edition, 2005.

4. Harris W.J., Cunningham C., “Antibody Therapeutics”. Springer, 1st

Edition,1996

5. Wawrzyuczak, E.J. “Antibody Therapy”., BIOS Scientific Publication, 1st

Edition, 1995.

6. Orrebaeuk, Carl A.K. “Antibody Engineering” Oxford University Press, 2nd

Edition 1995.

7. Shepherd P., Dean C., “Monoclonal Antibodies”. Oxford University Press,

1st Edition, 2000.

8. Rastogi, S.C. “Immunodiagnostics: Principles and Practice”., New Age

International, 1st Edition, 1996.

64

15MB204 ANIMAL BIOTECHNOLOGY L TPC

3 0 0 3

Course Objectives:

To understand the basic principles of animal cell culture techniques

and its application in agriculture, industry environment.

To teach the biology of animal viral vectors, this would facilitate the

students to understand modification of gene to produce the transgenic

animal.

To understand the steps involved in the animal cell culture process.

To understand the concept of transgenic animal production and its

application in the production of valuable products.

To know about the applications of animal biotechnology.

Course Outcomes:

Acquired knowledge about the importance of animal biotechnology for

the product ion of various therapeutic products.

Able to know about the molecular biology of the various viral vectors.

Able to perform animal tissue culture techniques and troubleshoot

problems associated with handling of animal cells.

Able to explain the application of knockout mice and transgenic

animals.

Able to manipulate animals for applications in environmental

monitoring and health care.


Scope of Animal Biotechnology and its role in the production of regulatory

proteins, blood products, vaccines, hormones and other therapeutic

proteins.

65

UNIT II MOLECULAR BIOLOGY 9

Biology of animal viral vectors- SV40, adeno virus, retrovirus, vaccinia

virus, herpes virus, adeno associated virus and baculo virus.

UNIT III CELL CULTURE TECHNOLOGY 10

Culturing of cells, primary and secondary cell lines, Cell culture-Scae up of

animal cell culture-monolayer culture, suspension culture; Various bio-

reactors used for animal cell culture-Roller bottle culture; Bioreactor

process control, stirred animal cell culture, Air-lift fermentor,

Chemostat/Turbidostat; High technology vaccines; Hybridoma technology;

Cell lines and their applications.

UNIT IV GENETIC ENGINEERING 10

Gene therapy-prospects and problems; Knockout mice and mice model for

human genetic disorder; Baculo virus in biocontrol; Enzyme technology,

Somatic manipulation of DNA, Nucleic acid hybridization and probes in

diagnosis- preparation of probes, evaluation and applications.

UNIT V APPLICATIONS OF ANIMAL BIOTECHNOLOGY 9

Rumen manipulation- probiotics embryo transfer technology, in vitro

fertilization, transgenesis- methods of transferring genes into animal

oocytes, eggs, embryos and specific tissues by physical, chemical and

biological methods; Biopharming -Transgenic animals (Mice, Cows, Pigs,

Sheep, Goat, Birds and Insects); Artificial insemination and embryo

transfer.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Glick B.R., Pasternack, J.J., “Molecular Biotechnology”, ASM Press,

3rd Edition, 2003.

2. Freshney R.I., “Culture of Animal Cells –a manual of basic

techniques and specialized applications”, John Wiley & sons, 7th

66

Edition, 2010.

3. Davis J.M., “Basic Cell Culture: A Practical Approach”, IRL Press,

2nd Edition, 2002.

4. Watson J.D., Gilman M., Witowski J. Zoller M., “Recombinant DNA”.

W.H. Freeman, 2nd Edition, 1992.

5. Masters J.R., “Animal Cell culture. Practical Approach “, Oxford

University Press, UK, 3rd Edition, 2000.

6. Lewin B., “Genes VIII”, Pearson Prentice Hall, 8th Edition, 2004.

III SEMESTER

15MB251 MICROBIAL AND IMMUNOTECHNOLOGY

LABORATORY

L T P C

0 0 6 3

Course Objectives:

To learn safety precautions followed in Microbiology and Immunology

laboratory.

Transfer living microbes using aseptic technique.

Demonstrate proficiency and use of the following in the laboratory:

streak plate isolation technique;bacterial staining techniques; wet

mounts; and proper culture handling.

Visually recognize and explain the macroscopic and microscopic

characteristics of microorganisms

Understand and explain environmental factors that influence microbes.

Properly obtain, culture, identify, and explain microorganisms in

environmental cultures.

Understand andexplain the interaction of antigen and antibody.

Daignosis of the disease using ELISA and commercially availble kits..

67

Course Outcomes:

By the end of this course, students will be able to:

Perform laboratory techniques commonly used in microbiology and

immunology.

Design experiments with appropriate standards and controls.

Analyze properly microbiology and immunology research data.

Present research results in a clear and efficient manner.

Use a scientific approach to problem solving.

Search efficiently the scientific literature in bacteriology, virology,

mycology, parasitology or immunology.

Analyze, interpret, summarize and clearly present scientific information.

EXPERIMENTS

PART I - MICROBIAL TECHNOLOGY

1. Disinfection, safety instructions; Preparation of media and Sterilization

2. Identification and staining of microbes (gram staining, Giemsa etc)

3. Enumeration of microorganisms by serial dilution

4. Growth curve, measure of bacterial population by turbidometry

PART II - IMMUNO TECHNOLOGY

1. Ethics, selection and handling of animals for immunological

experiments (Eg. Mice, Rats, Rabbits)

2. Preparation of antigen and Routes of immunisation (Intra-peritonial,

Sub-cutaneous, Intra-muscular, Intra-nasal, Oral)

3. Methods of bleeding (Eg. Tail bleeding, Intravenous, intraorbital)

4. Collection of serum, storage and purification of total IgG (salt

precipitation).

5. Evaluation of Antibody titre by direct ELISA

6. Evaluation of Antigen by Sandwich ELISA

7. Characterisation of antigens by native, SDS-PAGE

8. Characterisation of antigens by Immunoblotting

9. Conjugation of Immunoglobins (Streptavidin, colloidal gold)

68

10. Methods for prototype development of Immunodiagnostics (ICTcard)

11. Blood smear identification of leucocytes by Giemsa stain

12. Separation of mononuclear cells by Ficoll-Hypaque

13. Separation of spleenocytes and proliferation against mitogens

TOTAL: 90 PERIODS

REFERENCE BOOKS:

1. Harlow E. D., “Antibodies: A Laboratory Manual.” Panima, 2nd Edition.

2006.

2. Sambrook J., “Molecular Cloning: A Laboratory Manual.” Cold Spring

Harbor, /Panima, 3rd Edition. 2001

3. Coligan, John E., “Current Protocols in Immunology.” Wiley

Interscience, 1st Edition, 2003.

15MB352 ADVANCED MOLECULAR BIOLOGY AND

GENETIC ENGINEERING LAB

L

T

P

C

0 0 6 3

Course Objectives:

At the end of the course, the student would have learnt techniques of

gene cloning, screening of the clones and optimization of gene

expression

Monitor recombinant gene expression profile using electrophoresis and

hybridization techniques.

Gain hands on experience in RNA isolation and cDNA preparation.

Course Outcomes:

Techniques in cloning a gene of interest into vector.

Optimization of recombinant gene expression.

Confirmation of recombinant protein expression.

69


1. Preparation of genomic DNA

2. Preparation of plasmid DNA

3. Restriction digestion of the vector and Insert

4. Purification of restricted DNA fragments, gel elution and column

purification of restricted DNA

5. Ligation and transformation into E. coli

6. IPTG induction of recombinant E. coli

7. SDS-PAGE analysis of recombinant protein expression

8. Confirmation of recombinant protein expression by Western blot

9. Quantification of expressed recombinant protein by ELISA.

10. RNA Isolation

11. cDNA preparation from RNA

12. Southern hybridization

13. Site Directed Mutagenesis

14. Electroporation in Yeast

TOTAL: 75 PERIODS

REFERENCE BOOKS:

1. Sambrook J., David W.R., “The Condensed Protocols: From

Molecular Cloning: A Laboratory Manual” Cold Spring Harbor, 1st

Edition, 2006.

2. Frederick M. A., Roger B., Robert E. K., David D. M., Seidman J.G.,

John A.S., Kevin S., “Short protocols in molecular biology- Volume I

& II”, Wiley & sons, 2002.

3. Berger S., Kimmel A.R., “Methods in Enzymology: Guide to Molecular

Cloning Techniques, Volume-152”, Academic Press, 1st Edition, 1987.

70

4. Abelson J.N., Simon M.I., Wu R., Grossmann L., “Methods in

Enzymology: Recombinant DNA Part D, Volume-153”, Academic

Press, 1st Edition, 1987.


Enzymology: Recombinant DNA Part E, Volume-154”, Academic



Enzymology: Recombinant DNA Part F, Volume-155”, Academic


7. Abelson J.N., Simon M.I., Wu R., Goedddel D.V., “Methods in

Enzymology: Gene Expression Technology, Volume-185”, Academic


15MB353

ADVANCED BIOPROCESS AND

DOWNSTREAM PROCEESING LAORATORY

L T P C

0 0 6 3

Course Objectives:

To develop the skills of the students by providing hands on training in

enzyme catalysis.

To develop the skills of the students to formulate and optimize the

medium for effective fermentation process.

To train the students for the operation of bioreactor.

To understand the techniques and equipment involved in analyzing the

biomolecules in Biotechnology

To purify the biomolecules through various techniques.

71

Course Outcomes:

Ability to understand the mechanism and kinetics of the enzyme

reaction

Ability to understand the importance of medium formulation and

optimization of medium for their role in economy of the process

To successfully carry out aseptic fermentations using a bioreactor

Able to analyze the biomolecules based on their specific features

Able to concentrate the products through various techniques such as

precipitation and ultrafiltration.

Able to separate the biomolecules based on chromatography.


1. Enzyme kinetics, inhibition, effect of pH, temperature on enzyme

catalysis

2. Enzyme immobilization studies – Gel entrapment, adsorption and ion

exchange immobilization.

3. Optimization techniques – Plackett- Burman, Response surface

methodology.

4. Batch cultivation – recombinant E.coli – growth rate, substrate

utilization kinetics, product analysis after induction.

5. Fed batch cultivation of E. coli

6. Bioreactor studies: Sterilization kinetics, kLa determination, residence

time distribution

7. Animal cell culture production: T-flask, spinner flask, bioreactor

8. Cell separation methods; Centrifugation and microfiltration

9. Product concentration: Precipitation, ATPS, Ultrafiltration

10. High resolution purification; ion exchange, affinity and gel filtration

11. Freeze drying

72

TOTAL: 78 PERIODS

REFERENCES:

1. Bailey, J.E. and Ollis, D.F., “Biochemical Engineering Fundamentals",

McGraw Hill, 2ndEdition, 1986.


Facilities” Wiley-Blackwell, 1994.



4. Shuler, Michael L. and Kargi F., “Bioprocess Engineering “, Prentice

Hall, 1992.

5. Belter P.A., Cussler E.L., Houhu W., “Bioseparations: Downstream

Processing for Biotechnology”, Wiley Interscience Publications, 1st

Edition, 1988.

6. J.C. Janson and L. Ryden,”Protein Purification–Principles, High

Resolution, Methods and Applications”, Wiley Blackwell, 2nd Edition,

1998.

7. R.K. Scopes “Protein Purification– Principles and Practice”, Springer,

3rd Edition, 1994.

8. Ahuja S., “Handbook of Bioseparations”, Academic Press, 1st Edition,

2000.

9. Rehm H.J., Reed G., “Biotechnology: A Multi Volume Comprehensive

Treatise - Bioprocessing Volume-3” Wiley VCH, 2nd revised sub

Edition, 1993.

10. Rehm H.J., Reed G., “Biotechnology: A Multi Volume

Comprehensive Treatise - Special Processes Volume-10” Wiley

VCH, 2nd revised sub Edition, 2010.

73

CORE ELECTIVES

15MBC01 BIOCATALYST AND ENZYME TECHNOLOGY L T P C

3 0 0 3

Course Objectives:

To acquire basic knowledge about the classification and mechanism of

enzymes

To understand about the basic concepts in the kinetics of the enzyme

action.

To understand about the basic concepts in the immobilization of the

enzymes.

To know about the processes involved in functional group

transformation using the enzymes.

To know about the processes involved in enzymatic transformation.

Course Outcomes:

Able to understand the types of enzymes and their mode of action.

Able to deal about the kinetics involved in the enzyme actions

Able to deal with the creation of immobilized enzymes.

Acquired knowledge about the functional group transformation about

the enzymes.

Acquired knowledge about the enzymatic transformation.


Introduction to enzymes, Classification, Sources, Mechanism of enzyme

action. Strategies of purification of enzymes, criteria of purity, molecular

weight determination and characterization of enzymes, Enzymes of

biological importance - Acetyl cholinesterase, angiotensin converting

enzyme (ACE), ACE Inhibitors, HMG Co A reductase inhibitors, pseudo

cholinesterase, 5 -nucleotidase (5NT), glucose-6-phosphate dehydrogenase

(GPD), Isoforms, immunoreactivetrypsinogen (IRT) and chymotrypsin;

amylase isoenzymes.

74

UNIT II KINETICS OF ENZYME ACTION 9

Methods for investigating the kinetics of enzyme catalyzed reactions – Initial

velocity Studies, Estimation of Michaelis Menten parameters, Effect of pH

and temperature on enzyme activity, kinetics of inhibition. Modeling of rate

equations for single and multiple substrate reactions.

UNIT III IMMOBILIZED ENZYMES 9

Techniques of enzyme immobilization; kinetics of immobilized enzymes,

effect of solute, partition & diffusion on the kinetics of immobilized enzymes,

design and configuration of immobilized enzyme reactors; applications of

immobilized enzyme technology, Economic argument for immobilization.

UNIT IV ENZYMES IN FUNCTIONAL GROUP

TRANSFORMATION

9

Functional group interconversion using enzymes (hydrolysis reaction,

oxidation/reduction reactions, C-C bond formations), Retrosynthetic

biocatalysis, Chemoenzymatic synthesis of natural products. Industrial

process using enzymes for production of drugs, fine chemicals and chiral

intermediates.

UNIT V ENZYMATIC TRANSFORMATION 9

Reaction engineering for enzyme-catalyzed biotransformations. Catalytic

antibodies. Biocatalysts from extreme Thermophilic and Hyperthermophilic

microorganisms (extremozymes). The design and construction of novel

enzymes, artificial enzymes, Biotransformation of drugs (hydroxylation of

Steroids), Host Guest Complexation chemistry, enzyme design using

steroid templates, enzymes for production of drugs, fine chemicals and

chiral intermediates.

TOTAL: 45 PERIODS

75

REFERENCE BOOKS:

1. Bailey J.E., Ollis D.F. “Biochemical Engineering Fundamentals.”.

McGraw Hill, 2nd Edition 1986

2. Faber, Kurt “Biotransformations in Organic Chemistry: A Textbook.”,

5th Edition. Springer, 2008.

3. Palmer, Trevor. “Enzymes: Biochemistry, Biotechnology, Clinical

Chemistry.” 2nd Edition, East West Press, 2008.

4. Yeh W.K., Yang H.C., James R.M., “Enzyme Technologies:

Metagenomics, Biocatalysis and Biosynsthesis”, Wiley-Blackwell, 1st

Edition, 2010.



6. Lee, James M., “Biochemical Engineering.” PHI, 1st Edition, 1982.

7. Yeh W.K., Yang H.C., James R.M., “Enzyme Technologies:

Metagenomics, Biocatalysis and Biosynsthesis”, Wiley-Blackwell, 1st

Edition, 2010

15MBC02 FOOD PROCESSING AND BIOTECHNOLOGY L T P C

3 0 0 3

Course Objectives:

To introduce the various concepts of Food chemistry to the students

To acquire knowledge about the microbiology and biotechnology in food

processing.

To acquire knowledge about the unit operation involved in the food

processing.

To understand the concepts involved in the food preservation.

To acquire knowledge about the manufacture of various food products.

76

Course Outcomes:

Students acquired knowledge about the constituents, food additives and

enzymes in food processing.

Students acquired knowledge about the microorganisms associated

with food and food borne diseases.

Students acquired the knowledge of the fundamentals of food

processing.

Students understand the techniques involved in the food processing

and food preservation.

Students acquired the skills to gain employment in the food industry and

food product development.

UNIT I FOOD CHEMISTRY 9

Constituent of food – contribution to texture, flavour and organoleptic

properties of food; food additives – intentional and non-intentional and their

functions; enzymes in food processing.

UNIT II FOOD MICROBIOLOGY 9

Sources and activity of microorganisms associated with food; food

fermentation; food chemicals; food borne diseases – infections and

intoxications, food spoilage – causes.

UNIT III FOOD PROCESSING 9

Raw material characteristics; cleaning, sorting and grading of foods;

physical conversion operations – mixing, emulsification, extraction, filtration,

centrifugation, membrane separation, crystallization, heat processing.

UNIT IV FOOD PRESERVATION 9

Use of high temperatures – sterilization, pasteurization, blanching, aseptic

canning; frozen storage – freezing curve characteristics. Factors affecting

quality of frozen foods; irradiation preservation of foods.

77

UNIT V MANUFACTURE OF FOOD PRODUCTS 9

Bread and baked goods, dairy products – milk processing, cheese, butter,

ice-cream, vegetable and fruit products; edible oils and fats; meat, poultry

and fish products; confectionery, beverages.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Sivasankar B., “Food Processing and Preservation”, PHI, 1st Edition,

2002.

2. Frazier W.C., Westhoff D.C., “Food Microbiology” McGraw-Hill Book, 4th

Edition, 1988.

3. Damodaran, Srinivasan., “Fennema’s Food Chemistry” Marcel Dekker/

CRC, 4th Edition, 2008.

4. Chopra H.K., Panesar P.S., “Food Chemistry”. Narosa., 2nd Edition,

2010.

5. Jay, James M., “Modern Food Microbiology”. Springer, 7th Edition, 2005.

6. Vaclavik, Vickie A. and Elizabeth C., “Essentials of Food Science”,

Springer, 2nd Edition 2003.

15MBC03 PHARMACEUTICAL BIOTECHNOLOGY L T P C

3 0 0 3

Course Objectives:

This course aims to provide students with

Comprehensive understanding of the essentials of pharmacology

The theory, practices and equipment used in pharmaceutical industry

To understand about the pharmaceutical formulations.

Understanding of the importance, concepts and methods of drug

delivery systems

Knowledge of the importance of recombinant DNA technology derived

drugs in pharmaceutical industry and their regulations with case studies

78

Course Outcomes:

Students will learn the scientific basis of drug action

Students will appreciate the scientific rationale involved in candidate

drug development and preformulation development

Students will learn the basis of formulating the drug.

Students will appreciate the theoretical principles governing dosage

forms and drug delivery systems and the methods of their development

Students will gain the knowledge of role and importance of

biotechnology in pharmaceutical industry

UNIT I OVERVIEW OF PHARMACEUTICAL INDUSTRY 7

Drug Discovery and Development, Preformulation Development, Regulatory

Issues, Pharmaceutical Patents, Generics, biogenerics and biosimilars,

INN.

UNIT II PRINCIPLES OF PHARMACOLOGY 12

Pharmacodynamics, Pharmacokinetics, Adverse drug reactions and Drug

Interactions. Pharmacology of Antihypertensives, Antidiabetics, Anti-

hypercholesterolemics, Oral Contraceptives, NSAID’s and Antiulcer agents.

UNIT III PHARMACEUTICAL FORMULATIONS 12

Overview of dosage forms, Manufacture of tablets, capsules, liquid orals,

pharmaceutical dispersions, pharmaceutical aerosols and sterile

parenterals.

UNIT IV DRUG DELIVERY SYSTEMS 7

Controlled release formulations, transdermal, oral, oral-mucosal, colonic

delivery systems, injections and implants, liposomes and drug targeting,

applications of nanotechnology in drug delivery.

79

UNIT V BIOTECHNOLOGY DERIVED DRUGS 7

Insulin, erythropoietin, growth hormone, interferons and interleukins, growth

factors, Human Donor blood derived therapeutics, tPA, monoclonal

antibodies and engineered antibodies.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Lachman L. et al., “The Theory and Practice of Industrial Pharmacy”,

Varghese Publishing House, 3rd Edition, 1986.

2. Katzung B.G., “Basic and Clinical Pharmacology.” McGraw Hill, 12th

Edition, 2010.

3. Thomas G., “Medicinal Chemistry: An Introduction.” John Wiley, 2nd

Edition, 2007.

4. Walsh G., “Biopharmaceuticals: Biochemistry and Biotechnology.” John

Wiley & Sons, 2nd Edition, 2007.

5. Jain N.K., “Advances in Controlled and Novel Drug Delivery”, CBS

Publishers, 1st Edition, 2001.

6. Hardman, J.G., Lee E. L., Alfred G. G., “Goodman and Gilman’s

Pharmacological Basis of Therapeutics”., McGraw Hill, 11th Edition,

2006.

7. Lieberman H.A. et al, “Pharmaceutical Dosage Forms: Tablets (Vol. I, II

& III)”, Marcel Dekkar, 2nd Edition, 1989.

8. Ansel, H.C. “Pharmaceutical Dosage Forms and Drug Delivery

Systems”, Lippincott Williams & Wilkins, 7th Edition, 2000.

9. Aulton M.E., “Pharmaceutics: The Science of Dosage form Design.”

Churchill Livingstone, 2nd Edition, 2002.

10. Rodney J. Y., “Biotechnology and Biopharmaceuticals: Transforming

Proteins and Genes into Drugs.” Wiley Blackwell, 2nd Edition, 2013.

80

15MBC04 ENVIRONMENTAL BIOTECHNOLOGY L T P C

3 0 0 3

Course Objectives:

To teach students the scientific and engineering principles of

microbiological treatment technologies to clean up contaminated

environments and to protect the existing resources for the human

society.

To understand the fundamentals of environmental microbiology

To teach the bioremediation of organic contaminants and toxic metals

To teach biodegradation of environmental contaminants, and

engineering strategies for bioremediation.

To understand the alternative sources that does not affect the

environment.

Course Outcomes:

By the end of the course the student should be able to:

Describe and assess the role of microorganisms in biodegradation.

Describe and assess biological methods for pollution control, energy

and resource recovery from waste, bioremediation and how they can

contribute to clean technology.

Explain the physiological processes by which biological systems

contribute to environmental biotechnology.

Evaluate the impact of physicochemical, molecular and ecological

factors on biological processes contributing to environmental

biotechnology.

Describe the alternative energy sources and their impact on society

UNIT I ROLE OF SOIL MICROORGANISMS IN

BIODEGRADATION 7

Microbial flora of soil, Ecological adaptations, Interactions among soil

81

microorganisms, biogeochemical role of soil microorganisms.

Biodegradation, Microbiology of degradation and its mechanism,

Bioaugmentation, Biosorption, Bioleaching, Bioremediation- Types of

Bioremediation, Bioreactors for Bioremediation, Metabolic pathways for

Biodegradation for specific organic pollutants.

UNIT II CONCEPTS OF POLLUTION 11

Pollution- Sources of pollutants for Air, Water (ground water, marine),

Noise, Land and its characteristics- Pollution control and management-

Environmental monitoring & sampling, Physical, chemical and biological

methods and analysis- Air pollution- control and treatment strategies.

Modes of Biological treatment methods for wastewater- aerobic digestion,

anaerobic digestion, Anoxic digestion, the activated sludge process, Design

and modeling of activated sludge processes, Aerobic digestion, Design of a

trickling biological filter, Design of anaerobic digester.

UNIT III TREATMENT OF INDUSTRIAL WASTES 9

Industrial waste management- Dairy, Paper & Pulp, Textile, leather,

hospital and pharmaceutical industrial waste management, e-waste-

radioactive and nuclear power waste management- Solid waste

management.

UNIT IV BIOTECHNOLOGY TOOLS FOR ENVIRONMENTAL

MANAGEMENT 9

Molecular biology tools for Environmental management, rDNA technology in

waste treatment, Genetically modified organisms in Waste management,

Genetic Sensors, Metagenomics, Bioprospecting, Nanoscience in

Environmental management, Phytoremediation for heavy metal pollution,

Biosensors development to monitor pollution.

82

UNIT V ALTERNATE ENERGY SOURCES 9

Alternate Source of Energy, Biomass as a source of energy, Biocomposting,

Vermiculture, Biofertilizers, Organic farming, Biofuels, Biomineralization,

Bioethanol and Biohydrogen, Bio-electricity through microbial fuel cell,

energy management and safety.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Chakrabarty K.D., Omen G.S., “Biotechnology and Biodegradation.”

Advances in Applied Biotechnology Series, Vol.1, Gulf Publications Co.,

London, 1st Edition, 1989.

2. Metcalf, Eddy “Waste Water Engineering Treatment, Disposal and

Reuse.”, McGraw Hill, 4th Edition. 2003.

3. Scragg A., “Environmental Biotechnology”., Longman, 1st Edition, 1999.

4. Young, Murray M., “Comprehensive Biotechnology.” (Vol. 1-4) Elsiever,

1st Edition, 1985.

5. Hendrick, D., “Water Treatment Unit Processes – Physical and

Chemical”. CRC Press, 1st Edition, 2006.

6. Martin A.M., “Biological Degradation of Wastes.” Elsevier, 1st Edition,

1991.

7. Sayler, Gray S., Robert F., James W. B., "Environmental Biotechnology

for Waste Treatment.” Plenum Press, 1st Edition, 1991.

15MBC05

COMPUTER AIDED LEARNING OF STRUCTURE

AND FUNCTION OF PROTEINS

L T P C

3 0 0 3

Course Objectives:

To understand the components of the protein structure.

To familiarize students with protein structure function relationships

83

To introduce protein structure related databases and tools

To visualize, analyze and understand the relationship between

protein structure and function and effect of mutations.

To acquire knowledge about the engineering of proteins.

Course Outcomes:

Acquired knowledge about the components of the protein structure.

Able to retrieve sequences and structure of the proteins from the

databases

Acquired deep knowledge about the different classes of proteins and

their structure function relationships

Able to modify the proteins based on the requirements of purification

and identification.

Using computational techniques students will be better equipped in

understanding protein structure and function.

The knowledge can be utilized in designing protein engineering

experiments.

UNIT I COMPONENTS OF PROTEIN STRUCTURE 9

Introduction to Proteins, structure and properties of amino acids, the

building blocks of Proteins, Molecular Interactions and their roles in protein

structure and function, Primary Structure – methods to determine and

synthesis.

UNIT II PROTEIN BIOINFORMATICS 9

Protein sequence and structural databases, Multiple sequence alignment,

Secondary, Tertiary and Quaternary Structure of Proteins; Sequence and

Structural Motifs; Protein folding.

UNIT III OVERVIEW OF STRUCTURAL AND FUNCTIONAL

PROTEINS

9

Classes of Proteins and their Structure Function Relationships – alpha,

84

beta, alpha/beta proteins, DNA-binding proteins, Enzymes, IgG, membrane

proteins.

UNIT IV PROTEIN STRUCTURAL CLASSIFICATION

DATABASES

9

SCOP and CATH. Evolutionary relationships and Phylogenetic Studies.

UNIT V PROTEIN MODIFICATIONS 9

Post translational modifications, Engineering of proteins, Site directed

mutagenesis, Fusion Proteins, Chemical derivatization.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Voet, D.J. and Voet J.G. “Biochemistry. “ 3rd Edition. John Wiley & Sons ,

2004

2. Branden, Carl and John Tooze. “Introduction to Protein Structure.”

Garland Publications, 2nd Edition, 1999.

3. Creighton, Thomas E. “Proteins: Structures and Molecular Properties.”

W. H. Freeman, 2nd Edition, 1993.

4. Fersht, Alan., “Structure and Mechanism in Protein Science.” W.H.

Freeman, 1st Edition, 1999.

5. Holland, I.B. “ABC Proteins: From Bacteria to Man”. Academic Press,1st

Edition, 2003.

6. David W., “Proteins: Structure and Functions”, Wiley, 1st Edition, 2005.

15MBC06 METABOLIC PROCESS AND ENGINEERING L T P C

3 0 0 3

Course Objectives:

To achieve huge strain development programs to improve the

production

To understand about the analysis and medication of metabolic

85

pathways.

To provide an integration and quantification approach towards

metabolism and cell physiology.

To have a deep knowledge about the cellular metabolism,

comprehensive models for cellular reactions, and regulation of

metabolic pathways

To deal with metabolic flux analysis and metabolic control analysis for

increasing the productions.

Course Outcomes:

Able to increase the production by improving the strains.

Able to analyze the metabolic pathway.

Able understand the experimental methods involved in the analyzing of

the metabolic networks.

Able to devise strategies to optimal synthesis of metabolite.

Acquired knowledge about the role of metabolic engineering for the

production of various molecules.

UNIT I METABOLIC FLUX ANALYSIS 9

Introduction to metabolic engineering, comprehensive models of cellular

reactions with stoichiometry and reaction rates; metabolic flux analysis of

exactly/over/under determined systems. Shadow price, sensitivity analysis.

UNIT II TOOLS FOR EXPERIMENTALLY DETERMINING

FLUX THROUGH PATHWAYS

9

Monitoring and measuring the metabolome, Methods for the experimental

determination of metabolic fluxes by isotope labeling metabolic fluxes using

various separation-analytical techniques. GC-MS for metabolic flux analysis,

genome wide technologies: DNA /phenotypic microarrays and proteomics.

UNIT III CONSTRAINT BASED GENOMIC SCALE

METABOLIC MODEL

9

86

Development of Genomic scale metabolic model, Insilico Cells: studying

genotype-phenotype relationships using constraint-based models, case

studies in E. coli, S. cerevisiae metabolic network reconstruction methods,

optimization of metabolic network, Identification of targets for metabolic

engineering; software and databases for genome scale modeling.

UNIT IV METABOLIC CONTROL ANALYSIS AND

KINETIC MODELING

9

Fundamental of Metabolic Control Analysis, control coefficients and the

summation theorems, Determination of flux control coefficients. Multi-

substrate enzyme kinetics, engineering multifunctional enzyme systems for

optimal conversion, and a multi scale approach for the predictive modeling

of metabolic regulation.

UNIT V CASE STUDIES IN METABOLIC ENGINEERING 9

Metabolic engineering examples for bio-fuel, bio-plastic and green chemical

synthesis. Study of genome scale model in various systems for the

production of green chemicals using software tools. Validation of the model

with experimental parameters.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Stephanopoulos, G.N. “Metabolic Engineering: Principles and

Methodologies”. Academic Press / Elsevier, 1st Edition,1998.

2. Lee, S.Y. and Papoutsakis, E.T. “Metabolic Engineering”. Marcel Dekker,

1st Edition, 1998.

3. Nielsen, J. and Villadsen, J. “Bioreaction Engineering Principles”.

Springer, 1st Edition, 2007.

4. Smolke C.D. “The Metabolic Pathway Engineering Handbook

Fundamentals”, 2 Volumes CRC Press/ Taylor & Francis Group, 1st

Edition, 2010.

87

5. Voit E.O., “Computational Analysis of Biochemical Systems: A Practical

Guide for Biochemists and Molecular Biologists”. Cambridge University


6. Scheper T., “Advances in Biochemical Engineering Biotechnology -

Metabolic Engineering” Vol. 73, Springer, 1st Edition, 2001.

7. Cortassa S., Aon M.A., Iglesias A.A., and Llyod D., “An Introduction to

Metabolic and Cellular Engineering”. World Scientific Publishing, 2nd

Edition. 2012.

8. Kholodenko, Boris N. and Hans V. W., “Metabolic Engineering in the

Post Genomic Era”, Horizon Bioscience,1st Edition, 2004

15MBC07 BIOPROCESS MODELING AND SIMULATION L T P C

3 0 0 3

Course Objectives:

To know about the mathematical models involved in the design of the

bioreactors.

To have an idea about the models involved in the bioreactor modeling.

To understand about the dynamics involved in designing the

bioreactors.

To understand the concept of linear system analysis.

To outline the application of such modeling techniques.

Course Outcomes:

Acquired deep knowledge in the mathematical models of bioreactors.

Able to model the diffusion system in the bioreactors.

Able to analyze the functions involved in the modeling of the

bioprocess.

Able to analyze the stability and dynamics involved in the simulation of

the bioreactors.

Able to know about the various modeling techniques in designing the

bioreactor.

88

UNIT I MODELING OF BIOLOGICAL SYSTEMS 9

Modeling principles, model development from first principles. Modeling

approaches for biological systems – structured and unstructured systems;

Compartment models; Deterministic and stochastic approaches for

modeling structured systems.

UNIT II MODELLING OF DIFFUSION SYSTEMS (BIOFILM

AND IMMOBILIZED ENZYME SYSTEMS)

9

External mass transfer, Internal diffusion and reaction within biocatalysts,

derivation of finite model for diffusion-reaction systems, dimensionless

parameters from diffusion-reaction models, the effectiveness factor concept,

case studies; oxygen diffusion effects in a biofilm, biofilm nitrification

UNIT III MODELING BIOREACTOR 9

Bioreactor modeling: Ideal and non-ideal bioreactors; Stirred tank models;

characterization of mass and energy transfer distributions in stirred tanks,

Tower Reactor Model; Flow modeling, bubble column flow models, mass

transfer modeling, structured models for mass transfer in tower reactors,

process models in tower reactors, airlift models.

UNIT IV LINEAR SYSTEM ANALYSIS 9

Study of linear systems, linearization of non-linear systems; Simulation of

linear models using MATLAB; Parameter estimation and sensitivity analysis;

Steady state and unsteady state systems; stability analysis; Case study of

recombinant protein production.

UNIT V HYBRID AND OTHER MODELING TECHNIQUES 9

Advanced modeling techniques. Fuzzy logic, neural network, hybrid

systems and fuzzy logic systems; Case studies.

TOTAL: 45 PERIODS

89

REFERENCE BOOKS:

1. Bequette W., “Process Dynamics: Modeling, Analysis and Simulation”,

Prentice Hall, 1st Edition, 1998.

2. Said S.E.H., Parag G., “Conservation Equations and Modeling of

Chemical and Biochemical Processes, Marcel Dekker, 1st Edition, 2003.

3. Dale E.S., Duncan A.M., Thomas F.E., “Process Dynamics and

Control”, Wiley, 3rd Edition, 2010.

4. Bequettre, B.W. “Process Dynamics, Modeling, Analysis and

Simulation.” PHI, 1st Edition, 1998.

5. Said E.H., et al., “Conservation Equations and Modeling of Chemical

and Biochemical Processes”, Marcel Dekker, 1st Edition, 2003.

6. Dunn I.J., “Biological Reaction Engineering: Dynamic Modeling

Fundamentals with Simulation Examples”, Wiley-VCH, 1st Edition, 2003.

15MBC08 PLANT BIOTECHNOLOGY L T P C

3 0 0 3

Course Objectives:

To provide the students with the basic concepts in plant molecular

biology.

To acquire knowledge about the structure and function of chloroplast

and mitochondria.

To enable the students to understand the concept of plant symbiotic

association with bacteria

Outline of the principles of tissue culture and how it can be

manipulated.

To know about the applications of plant biotechnology.

Course Outcomes:

Acquired deep knowledge about the molecular biology of the

components in the plant cell.

Acquired deep knowledge about structure and function of the

components in the plant cell.

90

Able to identify the important vectors and genes involved in the

pathogenesis.

Able to engineer the metabolic pathway to increase the production of

the metabolites.

Apply to apply the techniques in developing new products.

UNIT I INTRODUCTION TO PLANT MOLECULAR BIOLOGY 9

Genetic material of plant cells, nucleosome structure and its biological

significance; transposons; outline of transcription and translation,

constitutive and differentially expressed genes in plants. Plant Functional

genomics; Reverse and Forward Genetics.

UNIT II CHLOROPLAST AND MITOCHONDRIA 9

Structure, function: Light and dark reaction and genetic material; rubisco

synthesis and assembly, coordination, regulation and transport of proteins.

Mitochondria: Genome, cytoplasmic male sterility and import of proteins,

comparison and differences between mitochondrial and chloroplast

genome, chloroplast transformation

UNIT III PLANT METABOLISM AND METABOLIC

ENGINEERING

8

Nitrogen fixation, Nitrogenase activity, nod genes, nif genes, bacteroids,

plant nodulins, production of secondary metabolites, flavanoid synthesis

and metabolic engineering.

UNIT IV AGROBACTERIUM AND PLANT VIRUSES 9

Pathogenesis, crown gall disease, genes involved in the pathogenesis, Ti

plasmid – T-DNA, importance in genetic engineering. Plant viruses and

different types, Viral Vectors: Gemini virus, cauliflower mosaic virus, viral

vectors and its benefits, vectors used for plant transformation, Methods

used for transgene identification

91

UNIT V APPLICATIONS OF PLANT BIOTECHNOLOGY 10

Outline of plant tissue culture, transgenic plants, herbicide and pest

resistant plants, molecular pharming, therapeutic products, RNAi,

Transgene silencing, ethical issues.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Grierson D., Covey, S.N.” Plant Molecular Biology.”, Blackie, 2nd

Edition 1988

2. Slater A et al., “Plant Biotechnology: The Genetic Manipulation of

Plants.”, Oxford University Press, 1st Edition, 2003.

3. Bhojwani S.S.,” Plant Tissue Culture: Theory and practice”, Elsevier

science, 1st Edition, 1986.

4. Raghvan V., “Developmental Biology of Flowering Plants” Springer, 1st

Edition reprint, 2000.

5. Mantell S.H., Smith H., “Plant Biotechnology: Volume 18, Plant

Biotechnology”, Cambridge University Press, 1st Edition, 1983.

6. Heldt, Hans-Walter. “Plant Biochemistry and Molecular Biology.”

Elsevier, 3rd Edition, 2005.

15MBC09 PLANT DESIGN AND PRACTICE L T P C

3 0 0 3

Course Objectives:

To acquire in depth knowledge about the design of fermenters and

other systems.

To know about the economic consideration involved in designing the

bioreactors.

To acquire knowledge about the pharmaceutical water system.

To know about the validation process of pharmaceutical system

facilities.

92

To know about the good manufacturing practices to be involved in

bioprocess and pharmaceutical industries.

Course Outcomes:

Acquired deep knowledge about the materials for the design of the

fermenters.

Able to know about the material used for constructing fermenters,

pipes and valves.

Able to understand the economics involved in design fermenter

based on the value of products produced.

Able to understand the significance of pharmaceutical facilities in the

production of the products.

Able to understand the good manufacturing practices to be followed

in each sectors of the plant

UNIT I PLANT DESIGN 12

Fermenter design, vessels for Biotechnology, piping and valves for

biotechnology, Pressure relief system. Materials of construction and

properties. Utilities for plant and their design introduction.

UNIT II PROCESS ECONOMICS 8

General fermentation process economics, materials usage and cost, capital

investment estimate, production cost estimate. Two case studies – one

traditional product and one recombinant product.

UNIT III PHARMACEUTICAL WATER SYSTEM 7

Grades of water, sanitary design, water treatment system, Water distribution

system, validation.

UNIT IV VALIDATION OF BIOPHARMACEUTICAL

FACILITIES

8

Introduction, why validation, when does validation occur, validation

93

structure, resources for validation, validation of systems and processes

including SIP and CIP.

UNIT V GOOD MANUFACTURING PRACTICES 10

Structure – quality management, personal, premises and equipment,

documentation, production, quality control, contract manufacturing and

analysis, complaints and product recall, self-inspection. Introduction to GLP

and its principles.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Peter, Max S. and Timmerhaus, Klaus D., “Plant Design and Economics

for Chemical Engineers”, McGraw Hill, 4th Edition, 1991.

2. “A compendium of Good Practices in Biotechnology”, BIOTOL Series,

Butterworth-Heiemann, 1st Edition, 1993.

3. Seiler, Jiing P., “Good Laboratory Practice: The why and How?” Springer,

1st Edition, 2001.

4. Lydersen, B.K. et al., “Bioprocess Engineering: Systems, equipment and

facilities”, John-Wiley, 1st Edition, 1994.

15MBC10 CLINICAL TRIALS AND BIOETHICS LT PC 3 0 0 3 Course Objectives: To provide understanding on the basic concepts of clinical trial

requirements and knowledge on documentation in health research

To learn the principles of ethics and regulatory issues in planning and

conducting experiments with animal and human subjects

To inculcate the understanding on the principles of clinical data

organisation, management and uses thereof for scientific research

94

Course Outcomes: Able to plan the drug development project.

Able to design the clinical trials.

Able to understand the ethical concepts and human rights involved in

the clinical trials.

Able to understand the concepts of the quality control to be maintained

in the clinical trials

UNIT I FUNDAMENTALS OF DRUG DEVELOPMENT

AND CLINICAL TRIALS 9

Origin and History of Clinical Research, Introduction to Drug Discovery and

drug Development, Clinical Trials in India –The National Perspective,

Clinical Trial Phase I, Clinical Trial Phase II, Clinical Trial Phase III, Clinical

Trial Phase IV – methods, Principles of sampling - Inclusion and exclusion

criteria, Methods of allocation and randomization, Termination of trial.

UNIT II ETHICAL CONSIDERATIONS IN CLINICAL TRIALS

9

Historical guidelines in Clinical Research- Nuremberg code, Declaration of

Helsinki, Belmont report, Research ethics and Bioethics – Principles of

research ethics; Ethical issues in clinical trials; Use of humans in Scientific

Experiments; the informed consent; Introduction to ethical codes and

conduct; Introduction to animal ethics; Animal rights and use of animals in

the advancement of medical technology

UNIT III GUIDELINES IN CLINICAL RESEARCH 9 International Conference on Harmonization (ICH) - Brief history of ICH,

Structure of ICH, ICH Harmonization Process, Responsibilities of

Stakeholders: Sponsors, Investigators, CROs, Monitors, Institutional ethics

committee

UNIT IV ESSENTIAL DOCUMENT 9 Essential Documents in Clinical Trials: SOP, Clinical Trial Protocol and

95

Protocol Amendment(S), Investigator Brochure, Master Files, Informed

Consent Forms, Consort statement, Case Record Form

UNIT V TRIAL MANAGEMENT 9

Project management in clinical trials - principles of project management;

Application in clinical trial management; Risk assessment

Pharmacovigilance, Project Auditing, Inspection.

TOTAL: 45 PERIODS REFERENCE BOOKS:

1. Lee, Chi-Jen; etal., “Clinical Trials or Drugs and Biopharmaceuticals.”

CRC / Taylor &Francis, 2011.

2. Matoren, Gary M. “The Clinical Research Process in the

Pharmaceutical Industry” Marcel Dekker, 1984.

15MBC11 ADVANCES IN MOLECULAR PATHOGENESIS L T P C

3 0 0 3

Course Objectives:

To understand the concept of host-pathogen interactions.

To understand the concept of immunological status and interactions

during infection

To understand the mechanisms of virulence in severity of infectious

diseases.

To study the history and development of vaccines and the advances in

vaccine development.

To study the life cycle and pathogenesis of various enteric pathogens.

To study the life cycle and pathogenesis of various non-enteric

pathogens.

Course Outcomes:

Students acquired knowledge about the basis of host pathogen

interactions.

96

The students will acquire knowledge in all aspects of host pathogen

interactions and gain knowledge in the immunological implications in

pathogenesis.

Students can acquire the knowledge of the fundamentals of microbial

toxins and their mode of action and also the host defense mechanisms

against pathogens and bacterial defense strategies.

Students will appreciate the scientific rationale involved in vaccines and

vaccine development.

Students will learn the life cycles of pathogens and mechanisms

underlying the pathogenesis of enteric and non- enteric pathogens.


Discovery of microscope, Molecular Koch’s postulates, Concepts of

disease, Virulence, Pathogenic cycle, Vaccines and its historical

perspective.

UNIT II HOST DEFENSE AGAINST PATHOGENS AND

BACTERIAL DEFENSE STRATEGIES

10

Skin, mucosa, cilia secretions, physical movements, physical and chemical

barriers to bacterial colonization, Mechanism of killing by humoral and

cellular defenses, Complement, Inflammatory process, Phagocytic killing,

Colonization, Adherence, Iron acquisition mechanisms, invasion and

intracellular residence, Evasion of complement, phagocytes and antibody

response.

UNIT III MOLECULAR MECHANISMS OF VIRULENCE 10

Virulence, Colonization factors, Microbial toxins, Secretion systems:

General secretory pathway, Two-step secretion, Contact dependent

secretion, Conjugal transfer system and Auto-transporters.

UNIT IV MECHANISMS UNDERLYING MOLECULAR

PATHOGENESIS

10

97

(COMMON ENTERIC PATHOGENS)

Shigella: Entry, Induction of macropinocytosis, Invasion of epithelial cells,

Intracellular motility and spread, Apoptotic killing of macrophages, Virulence

factors involved. E. coli: Enterotoxigenic E. coli (ETEC), labile & stable

toxins, Entero-pathogenic E. coli (EPEC), type III secretion, Cytoskeletal

changes, intimate attachment; Enterohaemerrohogic E. coli (EHEC),

Mechanism of bloody diarrhea and Hemolytic Uremic Syndrome,

Enteroaggregative E. coli (EAEC). Vibrio Cholerae: Cholera toxin, Co-

regulated pili, filamentous phage, survival.

UNIT V MECHANISMS UNDERLYING MOLECULAR

PATHOGENESIS

(COMMON NON-ENTERIC PATHOGENS)

10

Mycobacterium tuberculosis: The Mycobacterial cell envelope, Route of

entry, Uptake by macrophages, Latency and persistence, Entry into and

survival in phagocytes, Immune response against MTB, MTB virulence

factors, Emergence of resistance. Influenza virus: Intracellular stages,

Neuraminidase and Haemogglutinin in entry, M1 &M2 proteins in assembly

and disassembly, action of amantadine. Plasmodium: Lifecycle, erythrocyte

stages, transport mechanism and processes to support the rapidly growing

schizont, parastiparous vacuoles and knob protein transport, Antimalarials

based on transport processes.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Salyers, Abigail A., “Bacterial Pathogenesis: A Molecular Approach.”

ASM, 2nd Edition, 2002.

2. Groisman E.A., “Principles of Bacterial Pathogenesis”., Academic


3. Waksman G., Michael C., “Structural Biology of Bacterial

Pathogenesis”, ASM, 1st Edition, 2005.

4. Clark, Virginia L., “Bacterial Pathogenesis”, Academic Press, 1st Edition,

98

1997.

5. Williams P., “Bacterial Pathogenesis (Methods in Microbiology Series)”,

Academic Press, 1st Edition, 1998.

6. McClane, Bruce A.” Microbial Pathogenesis: A Principle Oriented

Approach.” Fence Creek Publications, 1st Edition, 1999.

7. Madigan, Michael T. “BROCK Biology of Microorganisms.” Pearson,

12th Edition, 2009.

8. Maloy and Stanly. “Genetic Analysis of Pathogenic Bacteria - A Lab

Manual.”Cold Spring Harbor, 1st Edition, 1996.

9. Hacker J., “Molecular Infection Biology”, John Wiley, 1st Edition, 2002.

15MBC12

NANOTECHNOLOGY APPLICATIONS

IN BIOLOGY

L T P C

3 0 0 3

Course Objectives:

To acquire deep knowledge in the field of nanoparticles and the

importance in biotechnology

To know about the fabrication and characterization of nanomaterials.

To understand the properties and measurements of nanomaterials.

To know about the process involved in conjugating with the

nanomaterials and their significance

To acquire knowledge about the drug delivery mechanism combined

with the nano molecules

Course Outcomes:

Able to understand the importance of nanoparticles in the field of

Biotechnology.

Able to understand the mechanism involved in the drug delivery

through nanoparticles.

Able to synthesize and characterize the nanoparticles.

Able conjugate the biomolecules with the nanoparticles.

99

Able to understand the techniques used in measuring the

characteristics of nano materials.

UNIT I NANOSCALE AND NANOBIOTECHNOLOGY 6

Introduction to Nanoscience and Nanotechnology; Milestones in

Nanotechnology; Overview of Nanobiotechnology and Nanoscale

processes; Physicochemical properties of materials in Nanoscales.

UNIT II FABRICATION AND CHARACTERIZATION OF

NANOMATERIALS

10

Types of Nanomaterials (Quantum dots, Nanoparticles, Nanocrystals,

Dendrimers, Buckyballs, Nanotubes); Gas, liquid, and solid –phase

synthesis of nanomaterials; Lithography techniques (Photolithography, Dip-

pen and Electron beam lithography); Thin film deposition; Electrospinning.

Bio-synthesis of nanomaterials.

UNIT III PROPERTIES AND MEASUREMENT OF

NANOMATERIALS

9

Optical Properties: Absorption, Fluorescence, and Resonance; Methods for

the measurement of nanomaterials; Microscopy measurements: SEM, TEM,

AFM and STM. Confocal and TIRF imaging.

UNIT IV NANOBIOLOGY AND BIOCONJUGATION OF

NANOMATERIALS

10

Properties of DNA and motor proteins; Lessons from nature on making

nanodevices; Reactive groups on biomolecules (DNA & Proteins); Surface

modification and conjugation to nanomaterials. Fabrication and application

of DNA nanowires; Nanofluidics to solve biological problems.

UNIT V NANO DRUG DELIVERY AND NANOMEDICINE 10

Properties of nanocarriers; drug delivery systems used in nanomedicine;

Enhanced Permeability and Retention effect; Blood-brain barrier; Active and

100

passive targeting of diseased cells; Health and environmental impacts of

nanotechnology.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Niemeyer C., Chad A.M., “Nano Biotechnology: Concepts, Applications

and Perspectives,.” , Wiley-VCHtion,1stediy 2004.

2. Shoseyov O., and Ilan L., “Nano BioTechnology: Bio Inspired Devices

and Materials of the Future.”, Humana Press, 1st Edition, 2007.

3. Rosenthal S.J., David W. W., “Nano Biotechnology Protocols”.

(Methods in Molecular Biology Series). Humana Press,1st Edition, 2005.

4. Sharon, Madhuri et al., “Bio-Nanotechnology: Concepts and

Applications.” Ane Books, 1st Edition, 2012

5. Clarke, A.R. and C.N. Eberhardt. “Microscopy Techniques for Material

Science.” CRC Press, 1st Edition, 2002.

15MBC13

RESEARCH METHODOLOGY IN

BIOTECHNOLOGY

L T P C

3 0 0 3

Course Objectives:

To know about concept in results and analysis of research.

To know about the importance of research in biotechnology.

To understand the basic concepts in design and methodology in

research.

To understand the system, components and the materials well to exploit

in engineering and technology.

To impart the essentials of research methodologies common to any

scientific pursuit and educate in the specific aspects of research

methodologies peculiar to the biological system.

101

Course Outcomes:

At the end of the course the students would have got the necessary

preparation for planning of experiments with appropriate controls and

test samples, analytical capabilities for proper interpretations, ability to

differentiate between facts and artifacts, research manuscript drafting,

publication etc.

Students would have got the necessary preparation for planning of

experiments with appropriate controls and test samples.

Students would have got analytical capabilities for proper

interpretations, ability to differentiate between facts and artifacts,

research manuscript drafting, publication etc.

Students will be able to take up research career with confidence right

from the beginning and their research output would be of good quality.

Student will be able to publish the research work and protect the

intellectual property.

UNIT I RESEARCH AND RESEARCH METHODOLOGIES

(WITH EXAMPLES)

9

Objectives of research, research process – observation, analysis, inference,

hypothesis, axiom, theory, experimentation, types of research (basic,

applied, qualitative, quantitative, analytical etc). Features of translational

research, the concept of laboratory to market (bench to public) and

Industrial R&D.

UNIT II RESEARCH IN BIOTECHNOLOGY – AN

OVERVIEW

9

Biological systems and their characteristic:. Type and outcome of research,

Exploratory and product-oriented research in all fields of biotechnology

(health, agri, food, industrial etc) – types of expertise and facilities required.

Interdisciplinary nature of biotech research, sources of literature for biotech

research.

102

UNIT III EXPERIMENTAL RESEARCH: BASIC CONCEPTS

IN DESIGN AND METHODOLOGY

9

Precision, accuracy, sensitivity and specificity; variables, biochemical

measurements, types of measurements, enzymes and enzymatic analysis,

antibodies and immunoassays, instrumental methods, bioinformatics and

computation, experimental planning – general guidelines.

UNIT IV RESULTS AND ANALYSIS 9

Importance and scientific methodology in recording results, importance of

negative results, different ways of recording, industrial requirement, artifacts

versus true results, types of analysis (analytical, objective, subjective) and

cross verification, correlation with published results, discussion, outcome as

new idea, hypothesis, concept, theory, model etc.

UNIT V SCIENTIFIC AND TECHNICAL PUBLICATION 9

Different types of scientific and technical publications in the area of

biotechnology, and their specifications, Ways to protect intellectual property

– Patents, technical writing skills, definition and importance of impact factor

and citation index - assignment in technical writing.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Marczyk, Geoffrey R. et al., “Essentials of Research Design and

Methodology.”John Wiley & Sons, 1st Edition, 2005.

2. Segel, I.H. “Biochemical Calculations: How to Solve Mathematical

Problems in General Biochemistry.”, John Wiley & Sons, 2nd Edition,

1976.

3. Korner, Ann M., “Guide to Publishing a Scientific Paper.” Bioscript


103

15MBC14

SENSORS AND INSTRUMENTATION FOR

BIOAPPLICATIONS

L T P C

3 0 0 3

Course Objectives:

To understand about the sensors and their applications in

biotechnology.

To understand the concepts in instrumentation and elements.

To understand the concepts and instruments used in the bioanalysis.

To have an idea about the instrumentation field in biotechnology.

To know about the application of sensors in the field of biotechnology.

Course Outcomes:

Students will be able to understand the concept of molecular interaction

in sensor instrumentation.

Students will be able to understand about the circuit elements and

measurement devices in instrumentation.

The students would understand the new dimensions and applications

of Biotechnology, especially involving instrumentation.

Able to integrate the biotechnology knowledge into other engineering

and technology disciplines to design and develop products, the true

purpose of technology course.

Students can be able to integrate the biosensors for the research in

biotechnology applications

UNIT I CONCEPTS IN MOLECULAR INTERACTIONS 9

Basic concepts in molecular interactions – types of forces involved

(electrostatic, H-bonding, hydrophilic and hydrophobic), characterization of

molecular recognition – affinity, avidity, binding and dissociation constants;

basic design and characterization of sensor instrumentation - precision,

sensitivity, resolution and specificity, errors and standard deviation, linear

regression analysis.

104

UNIT II CONCEPTS IN INSTRUMENTATION 9

Basic concepts in instrumentation: Basic concepts of circuit elements

(resistors, capacitors, conductors, diodes and transistors), Integrated

Circuits; Measurement devices: AC, DC Voltmeter, Ammeter, LCR Bridge,

Oscilloscope.

UNIT III BIOANALYSIS 9

Working principles of commonly used instrumentation in bioanalysis –

gravimetric, optical - microscopic, spectrophotometric, spectrofluorimetric,

luminometric; electrochemical; high-throughput devices: microplate

readers, biochemical autoanalyzers, thermocyclers, microarray readers.

UNIT IV SENSORS AND BIOSENSORS 9

Various types of sensors and biosensors– mass, chemical, biochemical,

optical, electrical, magnetic, electrochemical and thin film sensors;

matrices, sensor arrays, protein immobilization techniques and biosensors.

UNIT V APPLICATIONS OF SENSORS 9

Applications of sensors in agriculture, food, healthcare, environmental and

industrial Biotechnology. Practical aspects of biosensor development:

Fabrication of an immune biosensor and an enzymatic biosensor.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Yang, Victor C. “Biosensors and their Applications”. Kluwer Academic

/ Plenum Publishers, 1st Edition, 2000.

2. Cooper, Jon., and Cass A.E.G., “Biosensors: A Practical Approach”.,

Oxford University Press, 2nd Edition, 2004.

3. Freitag R., “Biosensors in Analytical Biotechnology”., Academic

Press, 1st Edition,1996.

4. Wise Donald L. “Bioinstrumentation and Biosensors”., Marcel

Dekker,1st Edition, 1991.

5. Hall E.A.H., “Biosensors”. Open University Press, 1st Edition, 1990.

105

15MBC15 BIOFUELS AND PLATFORM CHEMICALS L T P C

3 0 0 3

Course Objectives:

The objective of this course is to give knowledge on various forms of

biofuels and production of platform chemicals using the

microorganisms.

To know about the various sources for the production of biofuels.

To know about the production of ethanol.

To understand about the production of biodiesel.

To know about the production of other important biofuels and their

significance.

To understand about the chemistry involved in the biofuel production.

Course Outcomes:

Students undertaking the course will be able to understand the

importance of biofuels and platform chemicals.

An insight will be given to students to engineer / optimize/screen the

organisms for the production of these from renewable sources.

Able to know about the sources of ethanol and their production.

Able to know about the sources of biodiesel and their production.

Able to understand the production of platform chemicals from

microorganisms.


Cellulosic Biomass availability and its contents. Lignocellulose as a

chemical resource. Physical and chemical pretreatment of lignocellulosic

biomass. Cellulases and lignin degrading enzymes.

UNIT II ETHANOL 9

Ethanol as transportation fuel and additive; bioethanol production from

carbohydrates; engineering strains for ethanol production from variety of

carbon sources to improved productivity.

106

UNIT III BIODIESEL 9

Chemistry and Production Processes; Vegetable oils and chemically

processed biofuels; Biodiesel composition and production processes;

Biodiesel economics; Energetics of biodiesel production and effects on

greenhouse gas emissions Issues of ecotoxicity and sustainability with ;

expanding biodiesel production.

UNIT IV OTHER BIOFUELS 9

Biodiesel from microalgae and microbes; bio hydrogen production; bio

refinery concepts.

UNIT V PLATFORM CHEMICALS 9

Case studies on production of C3 to C6 chemicals such as Hydroxy

propionic acid, 1,3 propanediol, propionic acid, succinic acid, glucaric acid,

cis-cismuconic acid.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Lee, Sunggyu; Shah, Y.T. “Biofuels and Bioenergy”. CRC / Taylor &

Francis, 1st Edition, 2013.

2. Aye D., John N., Terry W., “Biofuels Engineering Process

Technology”, McGraw Hill, 1st Edition, 2008.

3. Wim S., Erik V., “Biofuels”, Wiley, 1st Edition, 2009.

15MBC16 GENOMICS AND TRANSCRIPTOMICS L T P C

3 0 0 3

Course Objectives:

To understand about organization and structure of genomes.

To learn about techniques in mapping and sequencing of the genome.

Study about the gene annotation and expression of genes using

functional genomics approach.

107

To learn about the microarray technology and data analysis.

To learn about the high throughput transcriptomics analysis.

Course Outcomes:

Able to understand the structure and organization of genome.

Able to understand mapping and sequencing strategies of genomes.

Able to perform annotation and expression analysis of genomes.

Able to understand the microarray technology and analysis.

Able to apply the tools of proteomics in medicine.

UNIT I ORGANIZATION AND STRUCTURE OF GENOMES 9

General organization and structure of genomes of viruses, prokaryotes,

eukaryotes, and organelles (chloroplast, mitochondrion).

UNIT II GENOME MAPPING AND SEQUENCING 9

Isolation and cloning of genomic DNA, Genome mapping (genetic and

physical), STS assembly, ESTs, RAPDs, RFLPs, AFLPs, SSLPs, SNPs,

linkage analysis, Restriction mapping, FISH, Chromosome painting,

microsatellites, Gene finding, annotation, ORF and functional prediction,

Chain termination and chemical degradation sequencing methods, Whole

genome shot-gun sequencing.

UNIT III LARGE SCALE GENOMICS/ FUNCTIONAL

GENOMICS ANALYSES

9

Genome-wide association (GWA) analysis; Comparative Genomic

Hybridization (CGH); Serial Analysis of Gene Expression (SAGE);

Massively parallel Signature Sequencing (MPSS); Analysis of alteration in

gene expression by Differential Display and Suppression Subtractive

Hybridization. Introduction to Next Generation Sequencing (NGS)

technologies for genome sequencing.

108

UNIT IV MICROARRAY TECHNOLOGY AND ANALYSIS 9

Designing and producing microarrays; cDNA microarray technology;

oligonucleotide arrays and designs; Sample preparation, labeling,

hybridization, generation and analysis of microarray data.

UNIT V HIGH-THROUGHPUT TRANSCRIPTOMICS

ANALYSES

9

Gene Expression analysis by cDNA and oligonucleotide arrays; Methylome

analysis using microarray; ChIP-on-Chip; Bioinformatic analysis of large-

scale microarray data for comparative transcriptomics: Data normalization;

Cluster analysis; Significance Analysis of Microarrays (SAM); Gene

Ontology and Pathway analysis.

TOTAL: 45 PERIODS

REFERENCES:

1. Hunt S.P., Livesey F.J., “Functional Genomics: A practical Approach”,

Oxford University Press, 1st Edition, 2000.

2. Primose, S.B., Twyman, R.M., “Principles of Genome Analysis and

Genomics.” Blackwell, 3rd Edition,2003

3. Jensen, Frank “Genomics: The Science and Technology behind the

Human Genome Project” Wiley – VCH, 1st Edition, 1999.

4. Spur N.K., Young B.D., Bryant S.P., “ICRF Handbook of Genome

Analysis.” Volume I & II. Wiley Blackwell, 1st Edition, 1998.

5. Gibson, G., S. V. Muse., “A Primer of Genome Science”. Sinauer, 1st

Edition, 2002.

6. Reece, R.J.,” Analysis of Genes and Genomes”, John Wiley, 1st

Edition, 2003

7. Suhai, S.” Genomics and Proteomics: Functional and Computational

Aspects.” Kluwer Academic/Springer, 1st Edition, 2002

8. Muller, Hans J., Thomas R., “Microarrays”, Academic Press, 1st

Edition, 2006.

9. Steve R., Lisa A.M., Roslin R.R., “Microarray Technology in Practice.”

109

1st Edition, 2009.

10. Allison, D. B., Page G. P., Beasley T. M., and Edwards J. W. “DNA

Microarrays and Related Genomics Techniques: Design, Analysis and

Interpretation of Experiments.” Chapman & Hall/CRC, 1st Edition,

2006.

11. Pevsner J. “Bioinformatics and Functional Genomics”, Wiley

Balckwell, 2nd Edition, 2009.

12. Rinaldis E. D., Lahm A., “DNA Microarrays”, Horizon Bioscience, 1st

Edition, 2007.

13. Stekel D., “Microarray Bioinformatics.” Cambridge University Press,

1st Edition, 2003.

15MBC17 PROTEOMICS AND MASS SPECTROSCOPY L T P C

3 0 0 3

Course Objectives:

To know about the strategies for identification and analysis of

proteins.

To have an overview about the types of ionization and mass

spectrometry in proteomics.

To acquire knowledge about the separation and processing of

proteins in proteomic analysis.

To have an overview about the comparative proteomic analysis.

To have an overview about the proteomics informatics.

To have an overview about the types of ionization and mass

spectrometry in proteomics

To acquire knowledge about the techniques involved in proteomics.

Course Outcomes:

The students would have gained knowledge on various areas of

proteomics including gel-based and non-gel based separation of

proteins, strategies for protein labeling and analysis of post-

110

translational modifications of proteins.

The students would have gained knowledge on mass-spectrometry

based sequencing and identification.

The students would have gained a deeper understanding on some of

the selected techniques.

The students would have gained a better understanding about the

comparative and proteomics analyses.

The students would have gained knowledge on proteomics

informatics.

UNIT I PROTEOMICS AND BIOLOGICAL MASS-

SPECTROMETRY

9

Over- view of strategies used for the identification and analysis of proteins;

Basics of Mass-spectrometry (MS) and bimolecular analysis; One-

dimensional (1-D) polyacrylamide gel electrophoresis (PAGE) of proteins;

Enzymatic cleavage of proteins in solution; In-gel digestion of protein bands;

Electrophoretic transfer of proteins on to membranes (PVDF).

UNIT II MASS-SPECTROMETRY IN PROTEOMICS 9

Common ionization methods for peptide/protein analysis (MALDI and ESI);

Principles of Time of Flight (TOF), Ion Trap (IT), Quadrupole (Q), Fourier

Transform-Ion cyclotron Resonance (FT-ICR), and Orbitrap mass

analyzers; Collision-Induced Dissociation (CID) of peptides; Introduction to

Ion detectors.

UNIT III SEPARATION AND PROCESSING OF PROTEINS

FOR PROTEOMICS ANALYSIS

9

Protein extraction from biological samples (Mammalian Tissues, Yeast,

Bacteria, and Plant Tissues); 2-DE of proteins for proteome analysis;

Difference in-gel electrophoresis (DIGE); Liquid chromatography

separations in proteomics (Affinity, Ion Exchange, Reversed-phase, and

size exclusion); Strategies for multidimensional liquid chromatography in

111

proteomics; Analysis of complex protein mixtures using Nano-liquid

chromatography (Nano-LC) coupled to Mass-spectrometry analysis.

UNIT IV COMPARATIVE AND QUANTITATIVE

PROTEOMICS

9

Rapid identification of Bacteria based on spectral patterns using MALDI-

TOF- MS. Comparative proteomics based on global in-vitro and in-vivo

labeling of proteins/peptides followed by Mass-spectrometry analysis: ICAT,

iTRAQ, SILAC. Analysis of Post-translational modification (PTM) of

proteins; Enrichment and analysis of phospho- and glyco- proteins;

Characterization of protein interactions using yeast two-hybrid system, Co-

immunoprecipitation followed by MS, and Protein microarrays.

UNIT V PROTEOMICS INFORMATICS 9

Identification of proteins by PMF and MS/MS data; Database search

engines for MS data analysis (Mascot, Sequest, and others); Proteomics

informatics strategies for biomarker discovery, analysis of protein functions

and pathways. Applications of proteomics (Disease diagnosis, drug

development, and plant biotechnology)

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Simpson R.J., “Proteins and Proteomics: A Laboratory Manual.” I.K.

International Pvt. Ltd, 1st Edition, 2003.

2. Pennington S. R., Dunn M.J., “Proteomics: From Protein Sequence to

Function.” Viva Books, 1st Edition, 2002.

3. Twyman R. M., “Principles of Proteomics.” Taylor & Francis, 1st

Edition, 2004.

4. O’Connor C. D. and Hames B. D. “Proteomics” Scion Publishing, 1st

Edition, 2008.

5. Dassanayake R. S., Gunawardene Y.I.N. S.” Genomic and Proteomic

Techniques.” Narosa, 1st Edition, 2011.

6. Siuzdak G. “Mass Spectrometry for Biotechnology.” Academic Press,

112

1st Edition, 1996.

7. Hoffman E. D., Stroobant V., “Mass Spectrometry – Principles and

Applications”, John Wiley& Sons, 1st Edition, 2007.

8. Chapman J.R., “Mass Spectrometry of Proteins and Peptides”,

(Methods in Molecular Biology Series Vol 146), Humana, 1st Edition,

2000.

9. Rosenberg I. M. “Protein analysis and Purification – Benchtop

Techniques.”, Springer, 1st Edition, 2005.

10. Scopes R. K.,” Protein Purification: Principles and Practice.”, Springer,

1st Edition, 1994

11. Chibbal D., LMcLafertty L., Schena M., “Protein Microarrays.”, Jones

and Bartlett, 1st Edition, 2005.

12. Smejkal G. B. and Lazarev A. V. “Separation methods in Proteomics.”

CRC Press, 1st Edition, 2006.

15MBC18 COMPUTATIONAL TECHNIQUES IN BIOPROCESS L T P C

3 0 0 3

Course Objectives:

To acquire knowledge about basic numerical methods.

To understand about the basic concepts involved in the modeling

techniques of bioprocess.

To have an overview about the algebraic equation.

To have an overview about the numerical differentiation.

To know about the initial value problems in designing bioreactors.

To know about the final value problems in designing bioreactors.

Course Outcomes:

Students will be trained in MATLAB and problem solving skills.

Students will be able to identify the parameters in the equations for

bioprocess modeling and calculations.

Students will be able to solve the algebraic equations

Students will be able to solve the initial value problems.

113

Students will be able to solve the final value problems for designing

the bioreactors.

UNIT I INTRODUCTION TO NUMERICAL METHODS 9

Computation and Error Analysis. Linear Systems and Equations: Matrix

representation; Cramer's rule; Gauss Elimination; Matrix Inversion; LU

Decomposition; Iterative Methods; Relaxation Methods; Eigen Values.

UNIT II ALGEBRAIC EQUATIONS 9

Bracketing methods: Bisection, Reguli-Falsi; Open methods: Secant, Fixed

point iteration, Newton-Raphson; Multivariate Newton’s method.

Regression and Curve Fitting, Linear regression; Least squares; Total Least

Squares; Interpolation; Newton’s Difference Formulae; Cubic Splines.

UNIT III NUMERICAL DIFFERENTIATION 9

Numerical differentiation, higher order formulae. Integration and Integral

Equations, Trapezoidal rules; Simpson's rules; Quadrature.

UNIT IV INITIAL VALUE PROBLEMS 9

ODEs: Initial Value Problems - Euler's methods; Runge-Kutta methods;

Predictor-corrector methods; Adaptive step size; Stiff ODEs.

UNIT V BOUNDARY VALUE PROBLEMS 9

ODEs: Boundary Value Problems- Shooting method; Finite differences;

Over/Under Relaxation (SOR). PDEs: Introduction to Partial Differential

Equations.

Note:

In practical MATLAB will be used and applications of these computational

114

techniques in bioprocess starting from simple enzyme kinetics to parameter

estimation in bioprocess modeling will be given as examples

TOTAL: 45 PERIODS

REFERENCE BOOKS

1. Tarun K.G., “Bioprocess Computations in Biotechnology”, Ellis

Horwood, 1st Edition, 1990.

2. Hamming R.W., “Numerical Methods for Scientist and Engineers”,

Dover Publications, 2nd Edition, 1987.

3. Morris T., Harris P., “ Ordinary Differential Equation for Scientist and

Engineers”, Dover Publication, 1st Edition, 1987

15MBC19 ADVANCED TECHNOLOGIES IN OMICS

SCIENCES

L T P C

3 0 0 3

Course Objectives:

To understand about the important techniques influencing the omics

sciences

To have an overview about next generation sequencing technologies.

To learn about the two dimensional gel electrophoresis and their

importance.

To acquire knowledge about the molecular components of microbes

and eukaryotes.

To have an overview about microarray and mass spectrometry.

Course Outcomes:

Students would have studied about the five most important technologies

and the associated techniques from the modern Omics sciences fields:

DNA microarray, protein microarray, Next generation sequencing, 2-D

gel electrophoresis of proteins, and Mass-spectrometry.

Students would have understood DNA microarray, protein microarray,

Next generation sequencing, 2-D gel electrophoresis of proteins, and

115

Mass-spectrometry.

Students would have understood the concept of protein microarray

Students would have understand Next generation sequencing

Students would have acquired the concept of 2-D gel electrophoresis of

proteins.

Students would have acquired deep knowledge on Mass-spectrometry.

Students would have learned how these technologies have driven the

multiples Omics Science disciplines.

UNIT I MICROARRAYS IN GENOMICS 9

Designing and producing microarrays; types of microarrays; cDNA

microarray technology; oligonucleotide arrays; Sample preparation, labeling,

hybridization, generation of microarray data. Gene Expression analysis by

cDNA and oligonucleotide arrays; ChIP-on-Chip; Bioinformatic analysis of

large-scale microarray data for comparative transcriptomics.

UNIT II NEXT GENERATION SEQUENCING

TECHNOLOGIES

9

Introduction to Next Generation Sequencing (NGS) technologies; Principles

of NGS by Roche/454, Illumina, Life Technologies, Pacific Biosciences, Ion

Torrent technologies; Applications of NGS to disease diagnosis and

personalized medicine.

UNIT III PROTEIN MICROARRAYS 9

Types of protein arrays; Protein microarray fabrication; Experimental

analysis of proteins arrays. Data acquisition and processing; Applications of

protein microarray types.

UNIT IV TWO-DIMENSIONAL GEL ELECTROPHORESIS

OF PROTEINS

9

Sample preparation, First-dimension IEF with IPG; Second dimensional

separation of proteins; Image analysis of 2-DE gels; Protein expression

116

profiling and comparative proteomics of complex proteomes using 2-DE.

UNIT V MASS-SPECTROMETRY 9

Basics of Mass-spectrometry (MS) and bimolecular analysis; Common

ionization methods for peptide/protein analysis (MALDI and ESI); Principles

of Time of Flight (TOF), Ion Trap (IT), Quadrupole (Q), Fourier Transform-

Ion cyclotron Resonance (FT-ICR), and Orbitrap mass analyzers; Collision-

Induced Dissociation (CID) of peptides; Analysis of complex protein

mixtures using Nano-liquid chromatography (Nano-LC) coupled to Mass-

spectrometry analysis; Analysis of metabolites using Gas-chromatograpgy

coupled to Mass-spectrometry; Mass-spectrometry analysis of Post-

Translational Modifications of proteins (Phosphorylation and glycosylation).

Accurate quantitation of peptides and small molecules using SRM/MRM

approach.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Schena M. “DNA Microarrays: A Practical Approach.”, Oxford

University Press, 1st Edition,2000.

2. Rinaldis E. D. and Lahm A., “DNA Microarrays.”, Horizon Bioscience,

1st Edition, 2007.

3. Muller H. J. and Roder T., “Microarrays.” Elsevier/ Academic Press, 1st

Edition, 2006.

4. Causton H. C., Quackenbush J., and Brazma A. “A Beginner’s Guide:

Microarray, Gene Expression Data Analysis.”, Blackwell, 1st Edition,

2004.

5. Schena M. “Protein Microarrays.” Jones and Bartlett,1st Edition, 2005.

6. O’Connor C. D. and Hames B. D., "Proteomics", Scion Publishing, 1st

Edition, 2008.

7. Hoffman E. D. and Stroobant V., “Mass Spectrometry: Principles and

Applications”, John Wiley & Sons, 1st Edition, 2007.

117

15MBC20 TISSUE ENGINEERING AND REGENERATIVE

MEDICINE

L T P C

3 0 0 3

Course Objectives:

To study the basics of tissue engineering and understand the concept

of engineering in therapeutics.

To acquire knowledge of the tissue architecture and composition.

To study nature and significance of stem cells and its applications.

To learn the characteristics and role of various biomaterials.

To study the clinical applications of stem cell therapy and tissue

engineering

Course Outcomes:

Students will learn and appreciate basics of tissue engineering and

role of angiogenesis and wound healing.

Students will understand the concept of biomaterials, their physical

and chemical characteristics and usage in tissue engineering.

Students will get an insight into different types of stem cells and their

applications.

They would get an exposure to the use of tissue engineering and

stem cells in various clinical applications and injuries.

They would appreciate the versatility and potency of stem cells in

therapies especially in all the major diseases that affect humans


Introduction to tissue engineering: Basic definition; current scope of

development; use in therapeutics, cells as therapeutic agents, cell numbers

and growth rates, measurement of cell characteristics morphology, number

viability, motility and functions. Measurement of tissue characteristics,

appearance, cellular component, ECM component, mechanical

measurements and physical properties.

118

UNIT II TISSUE ARCHITECTURE 9

Tissue types and Tissue components, Tissue repair, Basic wound healing

events, Applications of growth factors: Role of VEGF. Angiogenesis, Basic

properties, Cell-Matrix & Cell-Cell Interactions, Control of cell migration in

tissue engineering.

UNIT III BIOMATERIALS 9

Biomaterials: Properties of Biomaterials, Surface, bulk, mechanical and

biological properties. Scaffolds & tissue engineering, Types of Biomaterials,

biological and synthetic materials, Biopolymers, Applications of

biomaterials, Modifications of Biomaterials, Role of Nanotechnology.

UNIT IV STEM CELL BIOLOGY 9

Stem Cells : Introduction, Types & sources of stem cell with characteristics:

hematopoietic differentiation pathway, Potency and plasticity of stem cells,

sources, embryonic stem cells, hematopoietic and mesenchymal stem cells,

Stem Cell markers, FACS analysis, Differentiation, Stem cell systems-

Liver, neuronal stem cells, cancer stem cells, induced pluripotent stem cells.

UNIT V CLINICAL APPLICATIONS 9

Stem cell therapy, Molecular therapy, In vitro organogenesis,

Neurodegenerative diseases, spinal cord injury, heart disease, diabetes,

burns and skin ulcers, muscular dystrophy, orthopedic applications, Stem

cells and Gene therapy, Physiological models, tissue engineering

therapies, product characterization, components, safety, efficacy.

Preservation –freezing and drying. Patent protection and regulation of

tissue-engineered products, ethical issues.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Palsson B.O., Sangeeta N.B., "Tissue Engineering”, Pearson, 1st

Edition, 2009.

119

2. Meyer U., Meyer T.H., HandscheJ.; Wiesmann, H.P. “.Fundamentals

of Tissue Engineering and Regenerative Medicine”, Springer, 1st

Edition, 2009.

3. Bernard N. K., “Stem Cell Transplantation, Tissue Engineering, and

Cancer Applications”. Nova Science Publication, 1st Edition, 2008.

4. Raphael G., Richard S., “Stem Cell-Based Tissue Repair.”,

Cambridge/RSC Publishing, 1st Edition, 2011

5. R. Lanza, I. Weissman, J. Thomson, and R. Pedersen. “Handbook of

Stem Cells, Two-Volume, Volume 1-2: Volume 1-Embryonic Stem

Cells; Volume 2- Adult & Fetal Stem Cells”, Academic Press,

1stEdition, 2004.

6. Lanza R., Gearhart J. et al. “Essential of Stem Cell Biology.”,

Elsevier/Academic, 1st Edition, 2006.

7. Mao J.J., Vunjak N.et al.” Translational Approaches in Tissue

Engineering & Regenerative Medicine”., Artech House, INC

Publications,1st Edition, 2008.

120

SPECIAL ELECTIVE

ALLIED ELECTIVES OFFERED BY CIVIL ENGINEERING

DEPARTMENT

SL.

NO.

COURSE


1. 15SEA01 Condition Monitoring & Diagnostics 3 0 0 3

2. 15SEA02 Mechanics of Laminated Composites 3 0 0 3

3. 15SEA03 Advanced Metal Structures 3 0 0 3

4. 15SEA04 Manufacturing cost estimation 3 0 0 3

5. 15SEA05 Dam safety 3 0 0 3

6. 15SEA06 Bridge maintenance and management 3 0 0 3

7. 15SEA07 Experimental stress analysis 3 0 0 3

8. 15SEA08 Automobile Pollution Control 3 0 0 3

9. 15SEA09 Continuum mechanics -classical and FE

approach 3 0 0 3

ALLIED ELECTIVES

15SEA01

CONDITION MONITORING & DIAGNOSTICS L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the maintenance and reliability of equipment.

To outline the various types of maintenance.

To introduce the essentials of condition monitoring.

121

To provide an exposure on various types of condition monitoring.

To illustrate the vibration monitoring of some simple machines.

COURSE OUTCOMES:

At the end of the course, the student will able to

To conduct failure analysis.

Disseminate the various maintenance activities and their significance.

Acquaint with the fundamental principles of condition monitoring.

Identify the problem and apply the appropriate monitoring technique.

To assess the condition of equipment like pumps, motor through

vibration monitoring technique.


Productivity - Quality circle in Maintenance - Reliability, Reliability

assurance - Maintainability vs. Reliability - Failure analysis - Equipment

downtime analysis - breakdown analysis.

UNIT II TYPES OF MAINTENANCE 9

Maintenance type - Breakdown maintenance - Corrective maintenance,

Opportunity maintenance - Routine maintenance - Preventive and

predictive maintenance - Condition based maintenance systems - Design-

out maintenance.

UNIT III CONDITION MONITORING 9

Equipment health monitoring – Signals - Online & off-line monitoring -

Visual & temp. Monitoring - Leakage monitoring - Lubricant monitoring.

UNIT IV DIFFERENT TECHNIQUES 9

Ferrography - Spectroscopy - Crack monitoring - Corrosion monitoring -

thickness monitoring - Noise/sound monitoring - Smell/Odour monitoring -

Thermography.

122

UNIT V VIBRATION MONITORING 9

Vibration characteristics - Vibration monitoring - causes - identification -

measurement of machine vibration - C.M. of lubes and hydraulic systems -

C.M. of pipe lines, Selection of C.M. techniques Advantages.

TOTAL : 45 PERIODS

REFERENCE BOOKS:

1. Davies, "Handbook of Condition Monitoring", Chapman &Hall, 2012.

2. Rao B.K.N, “Handbook on condition monitoring” Elsevier Science Ltd.,

1996.

3. Armstrong, "Condition Monitoring", BSIRSA, 1988.

WEB REFERENCE:

http://bin95.com/TrainingSoftware/Condition-Based- Maintenance.html

15SEA02 MECHANICS OF LAMINATED COMPOSITES L T P C

3 0 0 3

COURSE OBJECTIVES:

To impart the knowledge on fundamentals of composites.

To study the behaviour of lamina.

To provide knowledge on behaviour of laminate.

To study the effect of Hygrothermal forces on mechanical behaviour

of composite.

To get exposed to soft computing techniques.

COURSE OUTCOMES:

At the end of the course the students will be able to

123

Use various laminated composites.

Analyze the behaviour of lamina.

Analyze the behaviour of laminates.

Analyse the effect of Hydrothermal forces on mechanical behaviour

Familiarize with numerical and soft computing techniques

UNIT I FUNDAMENTALS OF COMPOSITES 9

Classification and characteristics of composite materials - basic

terminology - uses of laminated composites - comparison of properties with

traditional materials.

UNIT II BEHAVIOUR OF LAMINA 9

Stress - strain relationship for anisotropic - orthotropic and isotropic

materials - transformation of elastic constants - failure criteria for an

orthotropic lamina - introduction to micromechanical behaviour - law of

mixture for E1, E2, G12, V12.

UNIT III BEHAVIOUR OF LAMINATE 9

Classical lamination theory - stress - strain relationship for laminate -

extensional bending and coupling stiffness - different configurations and

corresponding stiffness - strength of laminates - inter-laminar stresses -

introduction to behaviour of thin walled laminated structures.

UNIT IV HYGROTHERMAL EFFECTS 9

Effect of Hygrothermal forces on mechanical behaviour - Micromechanics

of Hygrothermal properties - Hygrothermal strains - free thermal strains -

stress strain relations - CTE and CME of laminates and determination of

stresses.

UNIT V COMPUTER AIDED ANALYSIS AND DESIGN 9

124

Introduction to numerical - soft computing techniques for the analysis - Design

of laminated composites.

TOTAL : 45 PERIODS

REFERENCE BOOKS:

1. Agarwal, B.D. and Broutman, L.J., “Analysis and Performance of Fiber

Composite”, John Wiley, 2006.

2. Johns, R.M., “Mechanics of Composite Materials”, Taylor &

Francis,1999

3. Madhujit Mukhopadhyay, “Mechanics of Composite materials and

structures”, Universities press (India) Pvt. Ltd., 2004.

15SEA03 ADVANCED METAL STRUCTURES L T P C

3 0 0 3

COURSE OBJECTIVES:

To outline the basic concepts in the design of industrial building

components.

To get exposed to the design of structures subjected to wind and

seismic forces.

To provide knowledge in the concept of plastic analysis.

To introduce the basic concepts of cold formed thin walled members.

To gain knowledge on pre-engineered buildings.

COURSE OUTCOMES:


Design the members which are subjected to lateral and axial loads

Analyze and design tall structures.

Perform plastic analysis of frames.

Design the cold formed thin walled members.

125

Design the Purlins and girders subjected to different load conditions.

UNIT I GENERAL 9

Design of members subjected to lateral loads and axial loads - Analysis

and Design of industrial building bents - cranes Gantry Girders and Crane

columns - Bracing of Industrial Buildings and Bents

UNIT II TALL STRUCTURES 9

Analysis & Design of Steel Towers - Trestles & Masts Subjected to wind

and earthquake forces.

UNIT III PLASTIC ANALYSIS 9

Introduction - Shape factors - moment redistribution - static - Kinematic and

uniqueness theorems - combined mechanisms - Analysis of single bay and

two bay portal frames - Methods of plastic moment distribution - Effect of

Axial force and Shear force on plastic moment - connections - moment

resisting connection.

UNIT IV COLD FORMED SECTIONS 9

Types of cross sections - Design of cold formed thin walled members -

local Buckling and post buckling strength - Beams - Columns -beam

columns - connections.

UNIT V PRE ENGINEERED BUILDING 9

Introduction-Rigid frame End - Post and beam End - Design of Purlins and

girders subjected to different load conditions - Limitations of pre-engineered

buildings -Advantages Comparison with Conventional Steel Buildings.

TOTAL : 45 PERIODS

REFERENCE BOOKS:

1. Dayaratnam, “Design of Steel Structures”, A.H.Wheeler Publishing Co.,

126

7th Edition, 2008.

2. A.S.Arya, “Design of Steel Structures”, Nem Chand & Co, 2001

3. Lin.S.Beedlc, “Plastic Design of Steel Frames”, John Wiley & Sons,

1958.

4. Horne. M.R. and Morn’s L.J. “Plastic Design of Low-Rise Frames”,

Granada Publishing Ltd., New York, 1981.

5. Salmon. C.G and Johnson, J.E. , “Steel Structures Design and

Behaviour”, Harper and Row, 1982.

6. Wie-Wen Yu, “Cold-Formed Steel Structures”, McGraw Hill Book

Company, 1973.

15SEA04 MANUFACTURING COST ESTIMATION L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the basics of cost estimation and different types of

cost estimating methods.

To impart knowledge on cost and various factory expenses.

To provide knowledge on budget and measures of cost economics.

To study the cost estimation in different shops.

To understand machining time and cost estimation for the different

process.

COURSE OUTCOMES:


Understand the different types of cost estimating methods.

Calculate cost and expenses of various factory processes.

Acquire knowledge on measures of cost economics.

Calculate the process cost involved in different shops.

Work out machining time and cost for the different process.

127

UNIT I COST ESTIMATION 9

Objective of cost estimation - costing - cost accounting - classification of

cost - Elements of cost - Types of estimates - methods of estimates - data

requirements and sources - collection of cost - allowances in estimation.

UNIT II COSTS AND EXPENSES 9

Aims of costing and estimation - Functions and procedure - Introduction to

costs - Computing material cost - Direct labour cost - Analysis of overhead

costs - Factory expenses - Administrative expenses - Selling and

distributing expenses - Cost ladder - Cost of product.

UNIT III COST ECONOMICS 9

Budget - need - Types - Budgetary control - Objectives – Benefits,

Measures of cost economics - Make or buy decision and Analysis, -

Depreciation - Causes of depreciation - methods of Depreciation,

Allocation of overheads.

UNIT IV ESTIMATION OF COSTS IN DIFFERENT SHOPS 9

Estimation in Forging shop - Losses in forging - Forging cost - Estimation in

welding shop - Gas cutting - Electric welding - Estimation in foundry shop -

Pattern cost - Casting cost - Illustrative examples.

UNIT V ESTIMATION OF MACHINING TIMES AND COSTS 9

Estimation of machining time for lathe operations - drilling - boring - shaping -

planning - milling and grinding operations - Illustrative examples.

TOTAL : 45 PERIODS

128

REFERENCE BOOKS:

1. Adithan. M, “Process Planning and Cost Estimation”, New Age

International (P) Ltd., 2007.

2. Chitale.A.K and Gupta.R.C, “Product Design and manufacturing”,

Prentice Hall of India, New Delhi, 2011.

3. Banga.T.R and Sharma.S.C, “Mechanical Estimating and Costing

including contracting”, Khanna publishers, New Delhi, 2001.

4. Joseph G. Monks, “Operations Management, Theory and Problems”,

McGraw Hill Book Company, New Delhi, 1987.

5. Narang.G.B.S and Kumar.V, “Production and Planning”, Khanna

Publishers, New Delhi, 1995.

6. Adithan.M. and Pabla.B.S, “Estimating and costing for the Metal

Manufacturing Industries”, CRC press, 1992.

15SEA05 DAM SAFETY L T P C

3 0 0 3

COURSE OBJECTIVES:

To enable the students to select the dams.

To study the analysis and design gravity dams.

To provide knowledge on design of spillways and energy dissipaters.

To study about various tests on the dam safety.

To gain knowledge on computer analysis of dams.

COURSE OUTCOMES:

At the end of the course, students will be able to

Know dam types and functions.

Analyze dams for stability.

Design dams.

Familiar with the safety aspects of dam.

Perform static and dynamic analysis using software.

129

UNIT I DAMS IN GENERAL 9

Definition uses and history of dam Construction - Modern dams - Various

kinds of dams - problems in dam construction - Classification of dams by

their uses and by hydraulic designs - rigid and non-rigid dams - factors

governing the selection of dams selecting of dam site.

UNIT II ANALYSIS, DESIGN AND CONSTRUCTION OF

GRAVITY DAMS

9

Introduction - Typical cross section - forces acting - Earth quake forces -

Weight of dam - Combination of forces for design - Modes of failures and

criteria for the structural stability of gravity dams - Gravity method or two

dimensional stability Analysis - Construction of gravity dams - construction

of galleries in gravity dams, shear keys - water stops - foundation

treatment for gravity dams.

UNIT III SPILLWAYS, ENERGY DISSIPATERS 9

Definition - Location - Subsidiary or emergency spillway or beaching

section - Design Consideration for the main spillway - controlled and

Uncontrolled spillways - Design of crest of spillways Energy dissipation

below overflow spillways - Energy dissipation below other types of

spillways - stilling basin.

UNIT IV REQUIREMENTS OF TESTS FOR DAM SAFETY 9

Introduction - Requirements for checking the safety of a dam - Earthen dam

evaluation - Dams with Heterogeneous construction materials - Concrete

dam evaluation - Non-destructive testing - Laboratory studies -

Requirement of repair materials - repair techniques of damages due to

cracks, cavitation.

UNIT V COMPUTER ANALYSIS OF DAMS 9

Identification of computer program - Methods of Analysis - Finite element

130

method -Analysis of dam - Static Analysis - Dynamic Analysis - Results

Analysis and interpretation - Eligibility of the packages used in the dam

Analysis.

TOTAL : 45 PERIODS

REFERENCE BOOKS:

1.William P. Creager, D Justin and Hinds, “Engineering for dams vol.1”,

Hesperides Press, 2006.

2.Notes on the training course on structural, Hydrological and foundation

Engineering aspects concerning Dam safety by

Prof.A.R.Santhakumar& Dr.S.Rajarathnam organized by the Dam Safety

Directorate, PWD, Chennai - 5 at the college of Engineering, Guindy,

Anna University, 2012.

15SEA06 BRIDGE MAINTENANCE AND MANAGEMENT L T P C

3 0 0 3

COURSE OBJECTIVES:

To introduce the philosophy behind bridge maintenance and

management.

To provide exposure on reliability concepts.

To provide training on various type of NDT.

To know the causes of bridge deterioration.

To familiarize the stress monitoring in bridge structures.

COURSE OUTCOMES:


131

Understand the basics of bridge maintenance and management.

Acquire knowledge on the assessment and evaluation procedure of

bridges.

Perform nondestructive testing and monitoring of bridge structures.

Identify the causes of bridge deterioration.

Carryout stress measurements in bridge structures.


Bridge maintenance management - The system - Inspection - Inspection

equipment - planning - condition rating.

UNIT II ASSESSMENT AND EVALUATION 9

Basic consideration - structural safety - analysis method - Reliability

concepts.

UNIT III NON DESTRUCTIVE TESTING 9

Concrete Elements - Corrosion analysis equipment - Resistivity

measurements - Rebar locators - Ultrasonic testing - Rebound hammer -

carbonation test - permeability testing - internal fracture tester - impulse

radar - infrared thermography - Endoscopy - Impact echo - Radiography -

coring - steel elements - masonry elements.

UNIT IV BRIDGE DETERIORATION 9

Basic Theory - Discount rate - Traffic disruption - Future development -

maintenance strategy - performance profiles - whole life assessment.

UNIT V STRESS MEASUREMENTS AND BRIDGE

MONITORING

9

In - situ residual stresses - stress relief principle - Indirect stress management

- Live load stresses - Monitoring - scour sensing - load cells - displacement

transducers - Traffic monitoring.

TOTAL : 45 PERIODS

132

REFERENCE BOOKS:

1. Ryall M J, "Bridge Management", Butterworth Heinemann, Oxford,

2009.

2. K. S. Rakshit, “Construction Maintenance Restoration & Rehabilitation

of Highway Bridges”, New central book agency (P) Ltd., 2003.

3. BojidarYanev, "Bridge Management", John Wiley & Sons INC., 2007.

4. Mohiuddin A. Khan, “Bridge and Highway structure Rehabilitation and

Repair”, McGraw Hill Pvt. Ltd., 2010.

15SEA07 EXPERIMENTAL STRESS ANALYSIS L T P C

3 0 0 3

COURSE OBJECTIVES:

To learn the basic principles of elasticity.

To impart knowledge on 2D Photo elasticity.

To understand the concepts of 3D Photo elasticity.

To have exposure on electrical strain gauges.

To understand the basics of Brittle coatings and Birefringence

coatings.

COURSE OUTCOMES:


Formulate solutions for problems on elasticity.

Evaluate various technics on 2D photo elasticity.

Work out stress formulations of 3D photo elasticity.

Perform strain measurement.

Detect cracks using various failure theories and coatings.

133

UNIT I BASIC ELASTICITY 9

Laws of stress transformation - principal stresses and principal planes -

Cauchy's stress quadric strain analysis - strain equations of transformation

- Cauchy's strain quadric - stress - strain relationship

UNIT II TWO DIMENSIONAL PHOTO ELASTICITY 9

Stress optics law - Optics of polarization plane and circular polariscope -

dark and light field arrangements - fringe multiplication - fringe sharp

ending - compensation techniques - commonly employed photo elastic

materials

UNIT III THREE DIMENSIONAL PHOTO ELASTICITY 9

Neuman's strain optic relationship - stress freezing in model materials for

three dimensional photo elasticity - shear difference method for stress

separation.

UNIT IV ELECTRIC RESISTANCE STRAIN GAUGES 9

Gauge construction and installation - temperature compensation - gauge

sensitivities - gauge factor - corrections for transverse strain effects -

factors affective gauge relation - rosette analysis - potentiometer and

Wheatstone’s bridge circuits for strain measurements.

UNIT V BRITTLE COATINGS AND BIREFRINGENCE

COATINGS

9

Introduction - coating stresses and failure theories- different types of crack

patterns - crack detection composition of brittle coatings - coating cure -

influence of atmospheric conditions - effects of biaxial stress field. Sensitivity -

reinforcing effects - thickness of birefringence coatings.

TOTAL : 45 PERIODS

134

REFERENCE BOOKS:

1. Dally and Riley, “ Experimental Stress Analysis”, McGraw Hill

Education 3rd Revised edition 2014

2. Dove and Adams, “Experimental stress analysis and motion

measurement”, Prentice Hall of India, Delhi 2014.

3. Durelly and Riley , “Introduction to Photo Mechanics”, Prentice Hall ,

2013

WEB REFERENCES:

1. http://textofvideo.nptel.iitm.ac.in/112106068/lec1.pdf

2. http://courses.washington.edu/me354a/photoelas.pdf

3. http://nptel.ac.in/courses/112106068/

15SEA08

AUTOMOBILE POLLUTION AND CONTROL L T P C

3 0 0 3

COURSE OBJECTIVES:

To create awareness about the various pollution sources.

To provide exposure on pollutant formation in SI engines.

To impart knowledge on pollutant formation in CI engines.

To get trained in control emission procedures.

To know about the measurement techniques emission standards and

test procedure.

COURSE OUTCOMES:


Identify the pollution sources and assess their impact.

Gain knowledge on pollutant formation in SI engines.

Assess the magnitude of pollutant formation in CI engines.

Know how to control emissions from engines.

135

Measure the pollution using the standard test procedures.

UNIT I POLLUTION SOURCES 9

Vehicle population assessment in metropolitan cities and contribution to

pollution - effects on human health and environment - global warming -

types of emission - transient operational effects on pollution.

UNIT II POLLUTANT FORMATION IN SI ENGINES 9

Pollutant formation in SI Engines - mechanism of HC and CO formation in

four stroke and two stroke SI engines - NOx formation in SI engines -

effects of design and operating variables on emission formation - control of

evaporative emission. Two stroke engine pollution.

UNIT III POLLUTANT FORMATION IN CI ENGINES 9

Pollutant formation in CI engines, smoke and particulate emissions in CI

engines - effects of design and operating variables on CI engine emissions

- Nox formation and control - Noise pollution from automobiles -

measurement and standards.

UNIT IV CONTROL OF EMISSIONS FROM SI AND CI

ENGINES

9

Design of engine, optimum selection of operating variables for control of

emissions - EGR - Thermal reactors - secondary air injection - catalytic

converters, catalysts - fuel modifications - fuel cells, Two stroke engine

pollution controls.

UNIT V MEASUREMENT TECHNIQUES EMISSION

STANDARDS AND TEST PROCEDURE

9

Orsat Apparatus - NDIR, FID - Chemiluminescent analyzers - Gas

Chromatograph, smoke meters, emission standards, driving cycles - USA,

Japan, Euro and India. Test procedures - ECE, FTP Tests. SHED Test -

chassis dynamometers - dilution tunnels.

136

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1.Paul Degobert, “Automobiles and Pollution”, Editions Technip

ISBN-2-7108-0676- 2, 1995.

2.Ganesan, V- Internal Combustion Engines- Tata McGraw-Hill Co – 2003.

3.S.K.Agarwal, “Automobile Pollution” Ashish publishing house, 1997.

15SEA09 CONTINUUM MECHANICS - CLASSICAL AND

FE APPROACH

L T P C

3 0 0 3

COURSE OBJECTIVES:

To study the classical theory of linear elasticity for two and three

dimensional state of stress.

To provide knowledge on 2D problems in rectangular coordinates.

To impart knowledge on 2D problems in polar coordinates.

To gain knowledge on analysis of stress and strain in 3Dimentional

problems.

To get familiar with finite element approach.

COURSE OUTCOMES:


Understand the theory of linear elasticity for two and three

dimensional state of stress.

Solve 2D problems in rectangular coordinates.

Formulate and obtain solutions for 2D problems in polar coordinates.

Analyze and determine the stresses in 3D problems.

Apply finite element approach to all structural elements.

137

UNIT I BASIC CONCEPTS 9

Definition of stress and strain at a point - component of stress and strain at

a point - strain displacement relation in Cartesian co-ordinates - constitutive

relations -equilibrium equations - compatibility equations and boundary

conditions in 2-D and 3-D cases - plane stress - plane strain - Definition.

UNIT II TWO-DIMENSIONAL PROBLEMS IN

RECTANGULAR COORDINATES

9

Airy’s stress function approach to 2-D problems of elasticity - Solution by

Polynominals - End Effects - Saint - Venant’s Principle - solution of some

simple beam problems - including working out of displacement

components.

UNIT III TWO - DIMENSIONAL PROBLEMS IN POLAR

COORDINATES

9

General equation in Polar coordinates - Strain and displacement relations -

equilibrium equations - Stress distribution symmetrical about an axis - Pure

bending of curved bars - Displacements for symmetrical stress distributions

- Bending of a curved bar by a force at the end - The effect of a small

circular hole on stress distribution in a large plate subjected to uni-axial

tension and pure shear.

UNIT IV ANALYSIS OF STRESS AND STRAIN IN THREE

DIMENSIONS

9

Introduction - Principal stresses - Determination of the principal stresses

and principal planes - Stress invariants - Determination of the maximum

shearing stress - Octohedral stress components - Principal strains - strain

invariants.

UNIT V FE APPROACH 9

2D and 3D Elements - CST-LST- Rectangular family - Tetrahedra and

Hexahedra - Shape functions - Element Stiffness matrix - Equivalent Loads-

Isoparametric formulation of Triangular and General quadrilateral elements -

Axisymmetric elements - Gauss Quadrature.

138

TOTAL : 45 PERIODS

REFERENCE BOOKS:

1. Timeshenko.S.P and Goodier.J.N, “Theory of Elasticity”, McGraw Hill

International Edition, 2010.

2. Reddy J.N, “An Introduction to Continuum Mechanics with Applications”,

Cambridge University press, 2013.

3. Robert D Cook et al, “Concepts and Applications of Finite Element

Analysis”, 4th Edition, John Wiley and Sons, New York 2001.

4. Srinath. L.S., “Advanced Mechanics of Solids”, Tata McGraw-Hill

Publishing Co ltd., New Delhi, 2009.

5. Sadhu Singh, “Applied stress analysis”, Khanna Publishers, 1983.

139

ALLIED ELECTIVES OFFERED BY EEE DEPARTMENT

SL.

NO.

COURSE


1. 15PEA01 Efficient Illumination Technologies 3 0 0 3

2. 15PEA02 Controllers for Robotics 3 0 0 3

3. 15PEA03 Analysis of Solar Energy Systems 3 0 0 3

4. 15PEA04 Converters, Inverters and Applications 3 0 0 3

5. 15PEA05 Hybrid and Electric Vehicle Technology 3 0 0 3

6. 15PEA06 Renewable Power Generation

Technology 3 0 0 3

15PEA01 EFFICIENT ILLUMINATION TECHNOLOGIES L T P C

3 0 0 3

Pre-requisites:

Basic electrical engineering, physics in lighting principle and basics of

economics.

COURSE OBJECTIVES:

To impart in-depth knowledge on energy savings.

To make the students learn the concepts of solid state lighting

technologies and their characteristics.

To educate the students on the design aspects of light fitting.

COURSE OUTCOMES:

Upon completion of the course, students will be able to

Explain the significance of energy savings.

Elucidate the solid state lighting technologies and their

140

characteristics.

Design the parameters related to light fitting.

UNIT I GREEN ENGINEERING: CHOICE OF LIGHTING

TECHNOLOGIES 9

Lighting upgrade- Green Benefits-Energy Savings-Green House Gas

Emission- Social Prospective- Deferred from Mercury - Clean disposal

options-Discount-Rational Economic Factor- Pay Back Formula. Cost of

Light- Energy Cost –Usage hours- Replacement Cost. Trade –off among

alternative technology-Daily Lighting Load Curves- Annual Cost of White

LED’s-Better investment.

UNIT II TRANSITION TO SOLID STATE LIGHTING 9

Technical Prospective Lighting Upgrade- Comparative Study of Lights-

Edison’s bulb- Fluorescent Tubes- CFL- Solid State Lighting- Key

Characteristics- Efficiency- Life Time-Spot Replacement - Group

Replacement- Colour- Co-related Colour Temperature- Black Body

Radiator- RF Noise and Flicker.

UNIT III RETROFIT ECONOMICS 9

Efficiency: Visible Spectrum- Luminous Flux- Human Eye- Photopia

Spectral Eye Sensitivity Curve- Device Efficacy, Source and Driving

Circuit Losses- System Efficacy with minimum Fixture Loss. Useful Life-

Lamp Lumen Depreciation- Junction Temperature-Heat Sink- Fixture

Reflectance Depreciation- Optics Cleaning- Maintenance Factor-

Coefficient of Utilization-Causes of Failure.

UNIT IV LUMINAIRE FIXTURE 9

Definition-Thermal-Electrical-Mechanical Design and Testing-Lamp

Holder- wiring- Control Gear- Driving Circuit-Housing. Optics-Light control

elements: Reflectors-Lenses and Refractors-Diffuser-Filters- Screening

devices- Mirror Louver. Specula reflector- Plane-Optical Gain-Uses-

Parabolic-Curved-Circular-Faceted-Trough versions. Accurate beam

Control- Control of spill light- practical uses-Combined Spherical and

Parabolic reflectors- Elliptical reflectors-Hyperbolic reflector- Spread

141

reflector- Moderate beam control- Diffuse reflector- Materials- Lenses and

refractors.

UNIT V LIGHT FITTINGS 9

Focusing Lours for flood lighting-Shielding angle- Cut-off angle- Barn

doors- colour filters- Light Distribution- Symmetric- and Asymmetric-

Diffused and Focussed- Direct and Indirect Beam spread classification-

Batwing light distribution.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Craig Delouse-“The Lighting Management Hand Book”- The

FAIRMONT PRESS.

2. Ines Lima Azededo, M. Granger Morgan and Fritz Morgan “The

Transition to Solid State Lighting” IEEE Proceedings, Vol.97,

No.3.March 2009.

3. A.R. Bean and R. H. Simons-“Lighting Fittings Performance and

Design”, 1st Edition, International Series of Monographs in Electrical

Engineering, 1968.

15PEA02 CONTROLLERS FOR ROBOTICS

L T P C

3 0 0 3

Pre-requisites: Fundamentals of Microprocessor, Microcontroller and

Control System.

COURSE OBJECTIVES:

To give students a well rounded education in Robotic Technology.

To impart knowledge on microcontroller programming for the

purpose of controlling robotics.

To expose the students to the concepts and basic algorithms

needed to make a mobile robot function reliably and effectively.

142

COURSE OUTCOMES:


Explain the techniques of Robotics Programming.

Implement the microcontroller in the programming of the

autonomous robot.

Describe and analyze control schemes frequently used at

industrial level.

UNIT I ARM ARCHITECTURE AND

PROGRAMMING

9

RISC Machine – Architectural Inheritance – Core & Architectures -

Registers – Pipeline - Interrupts – ARM organization - ARM processor

family – Co-processors. Instruction set – Thumb instruction set –

Instruction cycle timings - The ARM Programmer’s model – Interrupts –

Interrupt handling schemes- Firmware and boot loader.

UNIT II TRANSPORT AND APPLICATION LAYERS 9

TCP over Adhoc Networks – WAP – Architecture – WWW Programming

Model – WDP – WTLS – WTP – WSP – WAE – WTA Architecture –

WML – WML scripts.

UNIT III ONE DIMENSIONAL RANDOM

VARIABLES

9

Random variables - Probability function – moments – moment

generating functions and their properties – Binomial, Poisson,

Geometric, Uniform, Exponential, Gamma and Normal distributions –

Function of a Random Variable

UNIT IV COMMUNICATION WITH BUSES FOR

DEVICES NETWORKS

9

I/O devices: timer and counting devices, serial communication using I2C,

143

CAN, USB, and Buses: communication using profi bus, field bus, arm

bus, interfacing with devices/ serial port and parallel ports, device

drivers.

UNIT V ARM APPLICATION DEVELOPMENT 9

ARM Development tools – ARM Assembly Language Programming

and ‘C’ compiler program; Introduction to DSP on ARM –FIR Filter

– IIR Filter – Discrete Fourier transform

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Steve Furber, ‘ARM system on chip architecture’, Addision Wesley

2. Andrew N. Sloss, Dominic Symes, Chris Wright, John Rayfield

‘ARM System Developer’s Guide Designing and Optimizing

System Software’, Elsevier 2007.

3. Dananjay V. Gadre ‘Programming and Customizing the AVR

microcontroller’, McGraw Hill 2001.

4. Charles E. Perkins, “ Adhoc Networking”, Addison-Wesley, 2001.

5. N.Mathivanan, ‘Microprocessors, PC Hardware and Interfacing ,

PHI, second Printing 2003.

15PEA03 ANALYSIS OF SOLAR ENERGY SYSTEMS

L T P C

3 0 0 3

Pre-requisites: Basics of solar energy conversion

COURSE OBJECTIVES:

To impart knowledge on the fundamentals of solar energy

conversion systems.

To make the students gain knowledge on photovoltaic energy

conversion, energy storage and grid connection processes.

144

To make the students think on how to advance the current

technology of the solar energy systems for making the process

economical, environmentally safe and sustainable.

COURSE OUTCOMES:


Explain semiconductor physics, optical systems, load matching,

storage and grid connections related to photovoltaic engineering.

Elucidate the challenges in sustainable energy processes,

economic aspects, and future potentials of solar energy utilization.

Perform cost analysis, design photovoltaic systems for different

applications meeting residential and industrial needs.

UNIT I SOLAR RESOURCE 9

Introduction-Extra-terrestrial Solar Radiation-Solar Spectrum-Sun and

Earth Movement-Declination Angle-Angle of Sun rays on Solar Collector-

Optimum angle for fixed collector surface-Optimal inclination of collector

in summer and winter-Sun Tracking: One axis tracking-Two axis

Tracking-Azimuth Tracking

UNIT II SOLAR THERMAL SYSTEMS 9

Introduction-Classification-Performance indices: Collector Efficiency-

Concentration ratio-Temperature Range-Liquid Flat Plate Collector-

Evacuated Tube Collector-Cylindrical Parabolic Collector-Fixed mirror

solar concentrator-Central Tower Receiver-Solar Passive Heating and

Cooling System-Solar Industrial Heating Systems

UNIT III SOLAR PHOTOVOLTAIC(PV) SYSTEMS 9

Generic Photovoltaic Cell: Simple Equivalent circuit- More Accurate

Equivalent Circuit-Cells-Modules-Array-PV Curve-IV Curve-Impact of

irradiance and Cell Temperature on IV curves-Effect of Shading Series

145

and Parallel connection-Mismatch in cell/module-Mismatch in series

connection-Mismatch in Parallel Connection-Blocking diode- Bypass

Diodes-Simple Problems

UNIT IV BALANCE OF SOLAR PV SYSTEMS 9

Battery Parameters: Battery Capacity, Battery Voltage, Depth of

Discharge-Battery Life Cycle-C rating-Self Discharge- Factors Affecting

Battery Performance-Choice of a battery-Battery Charging and

Discharging Methods-Charge Controllers-Types of Charge Controller-

Maximum Power Point Tracking(MPPT)-Algorithms for MPPT: Constant

Voltage Method-Hill Climbing Method-DC DC-to- Converters for MPPT

traction

UNIT V PHOTOVOLTAIC SYSTEM DESIGN AND

APPLICATIONS

9

Introduction to Solar PV Systems-Stand Alone PV System Configuration-

Case Study: PV System Design for specified daily water Requirement,

Design of Standalone System with battery and AC or DC Load-Hybrid

PV Systems-Grid Connected PV systems- Life Cycle Costing

TOTAL: 45 PERIODS

TEXTBOOKS:

1. Sukhatme S P, Nayak J K, “Solar Energy: Principles of Solar

Thermal Collection and Storage”, Tata McGraw Hill, 2008.

2. Chetan Singh Solanki, “Solar Photovoltaics: Fundamentals,

Technologies and Applications”, PHI Learning Private

Limited,2012

REFERENCE BOOK:

1. Gilbert M. Masters, “Renewable and Efficient Electric Power

Systems”, Second Edition, John Wiley & Sons, 2013.

146

15PEA04 CONVERTERS, INVERTERS AND

APPLICATIONS

L T P C

3 0 0 3

Pre-requisites:

Basic knowledge on Electronic Devices and Circuit Theory.

COURSE OBJECTIVES:

To impart knowledge on the basics of power semiconductor

devices and their characteristics.

To impart knowledge on steady state operation of single phase

AC-DC converters and their applications.

To make the students analyze the operation of various DC-DC

converters and their applications.

To make the students analyze the operation of various DC-AC

converters and their applications.

To make the students analyze the operation of AC voltage

controllers and their applications.

COURSE OUTCOMES:


Explain the basics of power semiconductor devices and its

characteristics.

Explicate the basic concept of steady state operation of single

phase AC-DC converters.

Design and analyze the various DC-DC converters.

Analyze the operation of DC-AC converters.

Design and analyze the operation of AC-AC converters.

147

UNIT I INTRODUCTION TO POWER

SEMICONDUCTOR SWITCHES

9

Introduction to Power Electronics - Study of switching devices: structure,

operation, static and switching characteristics of SCR, TRIAC, BJT,

MOSFET, IGBT.

SCR: Two Transistor model, turn on circuits and commutation circuits,

series and parallel operation.

UNIT II AC-DC CONVERTER AND ITS

APPLICATIONS

9

1-pulse, 2-pulse converters - circuit, operation, waveforms - Estimation

of average load voltage and average load current for continuous current

operation - Input power factor estimation for ripple free load current-

Control of DC Motor using fully and half controlled converters.

UNIT III DC-DC CONVERTER AND ITS

APPLICATIONS

9

Step-down and step-up chopper - Time ratio control and current limit

control – Buck, boost, buck-boost converter –Isolated Converters: Fly

back and Forward converter- Battery charging using DC-DC Converters.

UNIT IV DC-AC CONVERTER AND ITS

APPLICATIONS

9

Single phase and three phase inverters (both 120 mode and 180 mode)

- PWM techniques: single, multiple, sinusoidal PWM, modified sinusoidal

PWM – Voltage and harmonic control- UPS-Types: Online and Offline

UPS.

UNIT V AC-AC CONVERTER AND ITS

APPLICATIONS

9

Single phase AC voltage controllers –Integral cycle control, phase angle

control - Estimation of RMS load voltage, RMS load current and input

148

power factor- Electronic Regulators for Fan.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Ned Mohan, Undeland and Riobbins, “Power Electronics: converters,

Application and design”, John Wiley and sons. Inc, Newyork, 1995.

2. Rashid M.H., “Power Electronics Circuits, Devices and Applications ",

Prentice Hall of India, New Delhi, 1995.

3. Cyril W.Lander, “power electronics”, Third Edition McGraw hill-1993

4. P.C Sen.," Modern Power Electronics ", Wheeler publishing Co, First

Edition, New Delhi-1998.

5. P.S.Bimbra, “Power Electronics”, Khanna Publishers, Eleventh

Edition, 2003. Bimal K Bose, “Modern Power Electronics and AC

Drives”, Pearson Education Asia 2002.

6. R W Erickson and D Maksimovic,”Fundamentals of Power

Electronics”, Springer, 2nd Edition.

7. Philip T.Krein, “Elements of Power Electronics” Oxford University

Press, 2004.

8. M.D. Singh and K.B Khanchandani, “Power Electronics”, Tata

McGraw Hill, 2001.

9. Vedam Subramanyam “Power Electronics”, by, New Age International

publishers, New Delhi 2nd Edition, 2006.

15PEA05 HYBRID AND ELECTRIC VEHICLE

TECHNOLOGY

L T P C

3 0 0 3

Pre-requisites:

Basic knowledge on batteries and electric motors.

COURSE OBJECTIVES:

149

To impart knowledge on the vehicle components and vehicle

movement.

To make the students grasp the architecture of Hybrid and Electric

Vehicles.

To make the students comprehend the need for Energy storage.

To provide knowledge on the electrical components and control

system for Hybrid and Electric Vehicles.

COURSE OUTCOMES:


Explain the components and Configuration of Hybrid and Electric

Vehicles.

Depict the types of batteries and their role in Hybrid and Electric Vehicles.

Describe the different control methods of Hybrid and Electric

Vehicles.

UNIT I INTRODUCTION TO HYBRID AND ELECTRIC

DRIVE TRAIN

9

Introduction-Components of Gasoline, Hybrid and Electric Vehicle- General

description of vehicle movement- Aerodynamic drag-Motion and Dynamic

equation for Hybrid and Electrical Vehicle- Adhesion, Dynamic wheel radius

and slip

UNIT II ARCHITECTURE OF HYBRID AND ELECTRIC

VEHICLES

9

Introduction-Energy Saving potential in Hybrid Vehicle-Different

configuration of Hybrid Vehicle: Series Hybrid System- Parallel Hybrid

System-Electric Vehicle (EV) Configurations- Electric Vehicle (EV) Drive

train Alternatives Based on Drive train Configuration- Electric Vehicle (EV)

Drive train Alternatives Based on Power Source

150

UNIT III BATTERIES 9

Basics- Parameters-Capacity, Discharge rate, State of charge, state of

Discharge, Depth of Discharge, Types-Lead Acid Battery-Lithium ion

battery- Lead Acid Battery-Lithium ion Battery-Technical characteristics-

Modelling of battery capacity- Calculation of Peukert Coefficient

UNIT IV ELECTRICAL COMPONENTS 9

Motors for Hybrid and Electric Vehicle-Suitability of BLDC, PMSM and

Induction Motor for Traction-Generic Power Converter Topology of Electric

Vehicle- DC-DC Converter: Types-Buck Converter-Bidirectional Converter-

DC-AC Converter-Working of Single and Three Phase Inverter- Sizing of

the Electric Machine-Power Train and Drive Cycles: New York City Cycle-

New European Driving Cycle- Fundamentals of Regenerative Braking

UNIT V CONTROL SYSTEM FOR ELECTRIC AND

HYBRID VEHICLE

9

Function of the Control System in HEVs and EVs-Different Operational

Modes- Overview of Control System-Control Variables-Principle of Rule

based Control Methods for ECU Design-State Machine based ECU Design-

Fuzzy Logic Based Control System- Case study of torque control and

battery recharging control based on fuzzy Logic

TOTAL: 45 PERIODS

TEXTBOOKS:

1. Mehrdad Ehsani, Yimin Gao, Ali Emadi, “Modern Electric, Hybrid

Electric, and Fuel Cell Vehicles: Fundamentals”, CRC Press, 2010.

REFERENCE BOOKS:

151

1. Iqbal Hussain, “Electric & Hybrid Vechicles – Design Fundamentals”,

Second Edition, CRC Press, 2011.

2. James Larminie, “Electric Vehicle Technology Explained”, John Wiley

& Sons, 2003.

WEB REFERENCES:

1. http://www.nptel.ac.in/courses/108103009/

15PEA06 RENEWABLE POWER GENERATION

TECHNOLOGY

L T P C

3 0 0 3

Pre-requisites: Basic knowledge on electrical power generation.

COURSE OBJECTIVES:

To impart knowledge on solar PV system, its design and MPPT.

To impart knowledge on wind energy systems.

To educate the students on other renewable sources of energy.

COURSE OUTCOMES:


Design stand alone and grid connected PV systems.

Select suitable wind turbine generators for different applications.

Explain the concept of Hybrid Energy Systems.

UNIT I SOLAR PHOTOVOLTAIC SYSTEM 9

Sun and Earth-Basic Characteristics of solar radiation-angle of sunrays on

solar collector-Photovoltaic cell-characteristics-equivalent circuit-

Photovoltaic modules and arrays

UNIT II SOLAR SYSTEMS DESIGN 9

152

PV Systems-Design of PV systems-Standalone system with DC and AC

loads with and without battery storage-Grid connected PV systems-

Maximum Power Point Tracking

UNIT III WIND ENERGY 9

Wind energy – energy in the wind – aerodynamics - rotor types – forces

developed by blades- Aerodynamic models – braking systems – tower -

control and monitoring system –design considerations-power curve - power

speed characteristics-choice of electrical generators

UNIT IV WIND ENERGY INTEGRATION 9

Wind turbine generator systems-fixed speed induction generator-

performance analysis-semi variable speed induction generator-variable

speed induction generators with full and partial rated power converter

topologies -isolated systems

UNIT V HYBRID AND OTHER SOURCES 9

Hybrid energy systems-wind-diesel system-wind-PV system-micro hydro-

PV system biomass- PV-diesel system-geothermal-tidal and OTEC

systems

TOTAL: 45 PERIODS

TEXTBOOKS:

1. Sukhatme S P, Nayak J K, “Solar Energy: Principles of Solar Thermal

Collection and Storage”, Tata McGraw Hill, 2008.

2. Chetan Singh Solanki, “Solar Photovoltaics: Fundamentals,

Technologies and Applications”, PHI Learning Private Limited,2012

REFERENCE BOOKS:

1. Gilbert M. Masters, “Renewable and Efficient Electric Power

Systems”, Second Edition, John Wiley & Sons, 2013.

ALLIED ELECTIVES OFFERED TO BY ECE DEPARTMENT

153

I. Communication Systems

S.

No

COURSE


1. 15CMA01 Bio MEMS 3 0 0 3

2. 15CMA02 High Speed Networks 3 0 0 3

3. 15CMA03 Telemetry Systems 3 0 0 3

4. 15CMA04 Light wave Communication 3 0 0 3

5. 15CMA05 Image Processing 3 0 0 3

II. VLSI Design

S.

No.

COURSE


1. 15VDA01 Sensors, Actuators and Interfaces 3 0 0 3

2. 15VDA02 Energy harvesting with materials and

microsystems

3 0 0 3

3. 15VDA03 Embedded and networking systems 3 0 0 3

4. 15VDA04 Extreme environment electronics 3 0 0 3

5. 15VDA05 Transducers and Signal conditioning

circuits

3 0 0 3

15CMA01 BIO MEMS L T P C

154

3 0 0 3

COURSE OBJECTIVES:

To be familiar of different sensors and actuators and fabrication

techniques used in MEMS

To identify the applications of MEMS in medical field.

COURSE OUTCOMES:

After completion of the course, the students will be able to

Select desired actuator for any application

Develop MEMS based system to diagnose disease

Implement the recently developed sensing technology used in BIO

MEMS

UNIT I MEMS AND MICROSYSTEMS 9

Typical MEMs and Microsystems, materials for MEMS - active substrate

materials- Silicon and its compounds, Silicon piezoresistors, Gallium

Arsenide, quartz, polymers. Micromachining photolithography, thin film

deposition, doping, etching, bulk machining, wafer bonding, LIGA

UNIT II MECHANICAL AND THERMAL SENSORS AND

ACTUATORS

9

Mechanics for MEMs design- static bending of thin plates, mechanical

vibration, thermo-mechanics, fracture and thin film mechanics. Mechanical

sensors and actuators – beam and cantilever –microplates, strain, pressure

and flow measurements, Thermal sensors and actuators- actuator based

on thermal expansion, thermal couples, thermal resistor, Shape memory

alloys- Inertia sensor, flow sensor

UNIT III ELECTROSTATIC AND PIEZOELECTRIC 9

155

SENSORS AND ACTUATORS

Parallel plate capacitor, pull in effect, Electrostatic sensors and actuators-

Inertia sensor, Pressure sensor, flow sensor, tactile sensor, comb drive.

Properties of piezoelectric materials, Piezoelectric sensor and actuator –

inchworm motor, inertia sensor, flow sensor.

UNIT IV MICROFLUIDIC SYSTEMS 9

Fluid dynamics, continuity equation, momentum equation, equation of

motion, laminar flow in circular conduits, fluid flow in microconduits, in

submicrometer and nanoscale. Microscale fluid, expression for liquid flow in

a channel, fluid actuation methods, dielectrophoresis, microfluid dispenser,

microneedle, micropumps-continuous flow system, micromixers

UNIT V SENSING TECHNOLOGIES FOR BIO-MEMS

APPLICATIONS

9

Culture-Based Biochip for Rapid Detection of Environmental Mycobacteria,

MEMS for Drug Delivery, Pharmaceutical Analysis Using Bio-MEMS,

Microchip Capillary Electrophoresis Systems for DNA Analysis

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Steven S. Saliterman “Fundamentals of BioMEMS and Medical

Microdevices”, Wiley Interscience, SPIE press, First Edition, 2006

2. Tai Ran Hsu, “MEMS and Microsystems design and manufacture”, Tata

McGraw Hill Publishing Company, New Delhi, First Edition, 2002

3. NitaigourPremchandMahalik, “ MEMS”, Tata McGraw Hill Publishing

Company, New Delhi,Second Reprint, 2008

4. Wanjun Wang, Steven A.Soper “ BioMEMS-Technologies and

applications”, CRC Press,BocaRaton,First Edition, 2007

5. Chang Liu,’ Foundations of MEMS’, Pearson Education International,

New Jersey, USA, Second Edition,2012

WEB REFERENCES:

156

1. https://www.mecheng.osu.edu/nlbb/files/nlbb/Nanotech_0.pdf

2. ‎http://www.tc.umn.edu/~drsteve/Lectures/Introduction%20to%20BioME

MS.pdf‎

15CMA02 HIGH SPEED NETWORKS L T P C

3 0 0 3

COURSE OBJECTIVES:

To be aware of high speed architectures

To know the features and limitations of high speed architectures

To discuss the congestion control mechanisms required for high

speed architectures

COURSE OUTCOMES:


Employ the right type of high speed architecture according to the

requirement

Administer congestion control and provide QoS

Provide compatibility between different high speed architectures

UNIT I ISDN AND FRAME RELAY 9

Introduction to High Speed networks - ISDN: Conceptual view – Standards

– Transmission structure – BISDN Frame Relay: Frame mode protocol

architecture – Call control – LAPF – Congestion – Traffic rate management

– Explicit congestion avoidance – Implicit congestion control.

UNIT II ASYNCHRONOUS TRANSFER MODE 8

Asynchronous transfer mode - ATM Protocol Architecture, ATM logical

Connection, ATM Cell - ATM Service Categories – AAL - Traffic and

Congestion control in ATM - Requirements - Attributes - Traffic

Management Frame work, Traffic Control – ABR traffic Management - ABR

rate control, RM cell formats, ABR Capacity allocations - GFR traffic

https://www.mecheng.osu.edu/nlbb/files/nlbb/Nanotech_0.pdf

157

management.

UNIT III CONGESTION CONTROL AND QOS IN IP

NETWORKS

9

Congestion Control in Packet Switching Networks: – The Need for Flow

and Error Control – Link Control Mechanisms – ARQ Performance – TCP

Flow Control – TCP Congestion Control – Performance of TCP Over ATM

Integrated Services Architecture – Queuing Discipline – Random Early

Detection – Differentiated Services – Resource Reservation: RSVP – Multi

protocol Label Switching – Real Time Transport Protocol.

UNIT IV WDM OPTICAL NETWORKS 9

Introduction to Optical Networks – Wavelength Division Multiplexing (WDM)

– Broadcast and select networks – switch architectures – channel

accessing – Wavelength routed networks – switch architectures – Routing

and wavelength assignment – Virtual topology design – IP over ATM over

WDM – IP over WDM.

UNIT V SONET AND SDH 9

High Speed LANs: Fast Ethernet – Switched fast Ethernet - Gigabit

Ethernet - 10Gigabit Ethernet

FDDI: Network configuration – Physical Interface – Frame transmission

and reception SONET: Introduction – Layers – Frames – STS multiplexing

– SONET networks – Virtual tributaries - Payload mappings – Packet over

SONET – Generic Framing Procedure – Transport services – SONET over

WDM – Traffic Grooming.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. William Stallings, “ISDN and Broadband ISDN with Frame Relay and

ATM”, Prentice-Hall of India, Fourth edition, 2004.

2. William Stallings, “High Speed Networks and Internets: Performance

and Quality of Service”, Pearson Education, Second edition, 2002.

3. C. Siva Ram Murthy and Mohan Gurusamy, “WDM Optical Networks:

158

Concepts, Design and Algorithms”, Prentice-Hall of India, 2002.

4. Fred Halsall, “Multimedia Communications – Applications, Networks,

Protocols”, Pearson Edition, 2001.

5. Greg Bemstein, BalaRajagopalan and DebanjanSaha, “Optical Network

Control – Architecture, Protocols and Standards”, Pearson Education,

2004.

6. Behrouz A Forouzan, “Data Communications and Networking”, Tata

McGraw-Hill, Fifth edition, 2013.

7. Behrouz A. Forouzan and Sophia Chung Fegan, “Local Area Networks”,

Tata McGraw-Hill, 2003.

8. Rajiv Ramaswami and Kumar N. Sivarajan, “Optical Networks: A

Practical Perspective”, Morgan Kaufmann, Third edition, 2004

9. .Uyless Black, “Optical Networks - Third Generation Transport Systems”,

Pearson Education, 2002.

WEB REFERENCES:

1. www.williamstallings.com/HsNet2e.html

2. ftp://ftp.prenhall.com/pub/esm/computer_science.s-

041/stallings/Slides/HsNet2e_PPT-Slides/

3. pages.cpsc.ucalgary.ca/~carey/CPSC641/.../atm/CongestionControl.ppt

15CMA03 TELEMETRY SYSTEMS L T P C

3 0 0 3

COURSE OBJECTIVES:

To apply the transmitter and receiver techniques for different

telemetry systems.

To apply the telemetry principles for practical applications.

COURSE OUTCOMES:

159


Develop and design components for telemetry applications.

Design a reliable telemetry system for different emerging field

applications.

Implement a system for different real time applications.

UNIT I TELEMETRY PRINCIPLES 9

Basic systems, Classification, Non electrical telemetry systems, Voltage

and current telemetry systems, Local transmitters and converters,

Frequency Telemetering, Power line carrier communication, Signal and

transmission basics, Symbols and codes

UNIT II MULTIPLEXED SYSTEMS 9

Frequency division multiplexing systems- FDM: An Introduction, IRIG

standards, FM circuits, Phase Modulation circuits, Receiving end, Phase

locked local loop, mixers. Time divison multiplexed systems- TDM/PAM

systems, PAM/PM SYSTEMS, TDM-PCM systems, digital multiplexer,

PCM reception, coding for varying levels, DPCM standards.

UNIT III MODEMS AND FILTERS 9

MODEMS- Introduction, Modems, QAM, modem protocol. FILTERS-

Introduction, Polynomial filter, active RC filter, universal filter circuits,

switched capacitor filters, digital filters.

UNIT IV TRANSMITTER AND RECEIVER 9

Transmitters introduction, Transmitter techniques, Interstage coupling,

Receiver. Antennas- ideal structure, dipoles, arrays, current distribution

and design consideration, Microwave antennas.

UNIT V APPLICATION OF TELEMETRY SYSTEMS 9

Satellite Telemetry: TT & C services, digital transmission systems in

satellite telemetry, TDM, The antenna, TT & C sub-systems, satellite

telemetry and communications: MA techniques. Fibre optical telemetry:

optical fibre cable, dispersion, losses, connectors and splices, sources

160

and detectors, transmitter and receiver circuits, coherent optical fibre

communication systems, wavelength division multiplexing.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. D. Patranabis, ‘Telemetry Principles’, Tata McGraw-Hill Education,

2007.

2. Swoboda G, ‘Telecontrol Methods and Applications of Telemetry and

Remote Control’, Reinhold Publishing Corp., London, 1991.

3. OndrejKrejcar , ‘Modern Telemetry’, InTech, 2011.

WEB REFERENCES:

1. http://free179.glareebook.org/pdf/telemetry-principles_yemev.pdf

2. http://www.britannica.com/EBchecked/topic/585928/telemetry

15CMA04 LIGHT WAVE COMMUNICATION L T P C

3 0 0 3

COURSE OBJECTIVES:

To Analyze the basic elements of light sources, Wavelength and

frequencies of light

To Analyze the different kind of fibers, losses, and fiber slicing and

connectors

To apply different types of photo detectors for constructing the

optical receiver

To evaluate the fiber optical receivers by measuring the

parameters

To apply the optical components for constructing the optical

networks.

161

COURSE OUTCOMES:


Analyze different kinds of light sources and Detectors used in any

applications

Design any optical communication systemfor different real time

applications.

Evaluate any optical related parameters

Design a reliable telemetry system for different emerging field

applications.

UNIT I OPTICAL SOURCES 9

Light sources: Sunlight, Torch light, LED and Laser light Optical

frequencies and Wavelength: Spectrum of Light sources LED internal -

quantum efficiency, Relationship between speed of light, wavelength

and frequency, light as an Electromagnetic waves comparison of LED

and Laser. Comparison of RF, Microwave and Lightwave communication

: Advantages and disadvantages.

UNIT II OPTICAL FIBER 9

Introduction, Refractive Index - Ray theory of transmission- Total internal

reflection-Acceptance angle – Numerical aperture –Structure of an

optical fiber Types of an optical fibers- Attenuation Fiber Bend losses

and Dispersion : Optical domain signal, electrical domain signal Optical

pulses for the digital data Optical fiber connectors, Fiber alignment and

Joint Losses – Fiber Splices – Fiber connectors-Fiber couplers

UNIT III OPTICAL DETECTORS 9

Optical Detectors: PIN Photo detectors, Avalanche photo diodes,

construction, characteristics and properties, Comparison of performance,

Photo detector noise –Noise sources, Signal to Noise ratio, Detector

response time.

162

UNIT IV FIBER OPTIC RECEIVER AND MEASUREMENTS 9

Fundamental receiver operation, Pre amplifiers, Error sources –

Receiver Configuration – Probability of Error – Quantum limit. Fiber

Attenuation measurements- Dispersion measurements –Optical

Spectrum Analyzer

UNIT V OPTICAL NETWORKS 9

Basic Networks – Broadcast and select WDM Networks –Bus topology

– Star topology - Wavelength Routed Networks – Routing and

wavelength Assignment – Different types of wavelength assignment-

Non linear effects on Network performance – Performance of WDM +

EDFA system – Solitons – Optical CDMA – Ultra High Capacity

Networks, OTDR.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Gerd Keiser, “Optical Fiber Communication”,Third Edition , McGraw

Hill, 2013

2. J.Gower, “Optical Communication System”, Prentice Hall of India,

2001

3. Rajiv Ramaswami, “Optical Networks “, Third Edition, Elsevier, 2009.

4. Govind P. Agrawal, “Fiber-optic communication systems”, Third

edition, John Wiley & sons, 2010.

WEB REFERENCES:

1. www.nptel.ac.in/courses/117101002/downloads/Lec19.pdf

2. www.ece466.groups.et.byu.net/notes/notes_source.ppt

163

15CMA05 IMAGE PROCESSING L T P C

3 0 0 3

COURSE OBJECTIVES:

To analyze the mathematical transforms necessary for image

processing.

To analyze image restoration procedures.

To analyze the image segmentation techniques.

To analyze the image compression procedures

COURSE OUTCOMES:


Simulate basic image processing algorithms

Develop algorithms for image enhancement and compression

Develop algorithms for image restoration and segmentation

Implement the algorithms for image compression applications

UNIT I IMAGEPROCESSING SYSTEM 9

Image Sampling – Quantization – Resolution, human Visual System,

Classification of Digital Images, Types, Elements of an Image-processing

System, File Formats, Applications, Image Transforms, various Image

Transforms (qualitative study only) Comparison, Colour-Image Processing,

Colour Formation, Colour Model, The Chromaticity Diagram.

UNIT II IMAGE ENHANCEMENT 9

Image Enhancement in Spatial Domain, Point Operation, Histogram

Manipulation, Linear and Nonlinear Gray-level Transformation, Local or

Neighborhood Operation, Median Filter, Image Sharpening, Bit-plane

Slicing, Enhancement in the Frequency Domain, Homomorphic Filter,

Zooming Operation, image Arithmetic.

UNIT III IMAGE RESTORATION AND DENOISING 9

Image Degradation, Image Blur, Classification of Image restoration

164

Techniques, restoration Model, Linear and Non-linear Image-restoration

Techniques, Blind-deconvolution Techniques, Image Denoising,

Classification of Noise in Image, Median Filtering, Trimmed Average Filter,

Performance Metrics in Image Restoration, Applications.

UNIT IV IMAGE SEGMENTATION 9

Image-segmentation Techniques, Region Approach, Clustering,

Thresholding Edge-based Segmentation, Edge Detection, Edge Linking,

Hough Transform, Active Contour, Watershed Transformation, Shape

Representation.

UNIT V IMAGE COMPRESSION 9

Image Compression, Image-compression Scheme, Fundamentals of

Information Theory, Run-length Coding, and Huffman coding, Dictionary-

based Compression, Predictive Coding, JPEG compression standard,

Scalar and vector Quantization.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Jayaraman. S, Essakkirajan.S, Veerakumar. T, Digital Image

Processing, McGraw Hill Educations, 2013

2. Rafael C. Gonzalez, Richard E. Woods, “Digital Image Processing',

Pearson Education Inc, Third Edition, 2009

3. Anil K. Jain, “Fundamentals of Digital Image Processing”, Prentice Hall

of India, Fifth Edition, Sixth reprint 2007 .

4. Kenneth R. Castleman, “Digital Image Processing”, Pearson, 2006

5. Rafael C. Gonzalez, Richard E. Woods, Steven Eddins, “Digital Image

Processing using MATLAB”, Pearson Education Inc, Third Edition, 2010.

6. William K. Pratt, , “Digital Image Processing”, John Wiley, Fourth

Edition, 2007

7. Milan Sonka, Vaclav Hlavac, Roger Boyle, “Image Processing, Analysis,

and Machine Vision”, Cengage Learning, Fourth Edition, 2014

165

WEB REFERENCES:

1. www.imageprocessingplace.com/

2. http://in.mathworks.com/products/image/

3. http://in.mathworks.com/discovery/digital-image-processing.html

15VDA01 SENSORS, ACTUATORS AND THEIR

INTERFACES

L T P C

3 0 0 3

COURSE OBJECTIVES:

Recognize different types of sensors and actuators for different

environments.

Converse the different measurements using sensors

COURSE OUTCOMES:


Analyze sensors for different type of measurements.

Decide different Actuators at the output.

UNIT I SENSORS AND ACTUATORS 9

Classification of Sensors and Actuators, General Requirements for

Interfacing, Units and Measures, Performance Characteristics of

Sensors and Actuators.

UNIT II TEMPERATURE, OPTICAL SENSORS AND

ACTUATORS

9

Thermoresistive Sensors, Thermoelectric Sensors, PN Junction

Temperature Sensors, Optical Units and materials, Effects of Optical

166

Radiation, Quantum-Based Optical Sensors, Photoelectric Sensors,

Coupled Charge (CCD) Sensors and Detectors, Thermal-Based Optical

Sensors, Active Far Infrared (AFIR) Sensors, Optical Actuators..

UNIT III ELECTRIC, MAGNETIC, MECHANICAL SENSORS

AND ACTUATORS

9

The Electric Field: Capacitive Sensors and Actuators, Magnetic Fields:

Sensors and Actuators, Magnetohydrodynamic (MHD) Sensors and

Actuators, Voltage and Current Sensors, Force Sensors,

Accelerometers, Pressure Sensors, Velocity Sensing, Inertial Sensors:

Gyroscopes.

UNIT IV ACOUSTIC, CHEMICAL SENSORS AND

ACTUATORS

9

Elastic Waves, Microphones, The Piezoelectric Effect , Acoustic

Actuators, Ultrasonic Sensors and Actuators, Piezoelectric Actuators,

Piezoelectric Resonators and SAW Devices, Electrochemical Sensors,

Potentiometric Sensors, Thermochemical Sensors, Optical Chemical

Sensors, Mass Sensors, Humidity and Moisture Sensors, Chemical

Actuation

UNIT V RADIATION SENSORS AND ACTUATORS, MEMS

AND SMART SENSORS

9

Radiation Sensors, Microwave Radiation, Antennas as Sensors and

Actuators, MEMS Sensors and Actuators, Smart Sensors and Actuators,

Sensor Networks.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. NATHAN IDA, “Sensors, Actuators and their Interfaces”, Scitech

publishing. 2013.

167

2. Vijay K.Varadan, K.J.Vinoy, S.Gopalakrishnan, “Smart Material

Systems and MEMS”, Wiley edition, 2006.

3. Hartmut Janocha, “Actuator : Basics and its Applications”, Springer,

2004.

WEB REFERENCES:

1. catalog.weidmueller.com/catalog/Start.do?localeId=en&ObjectID

2. www.seeedstudio.com/wiki/Grove_System

15VDA02 ENERGY HARVESTING WITH MATERIALS AND

MICROSYSTEMS

L T P C

3 0 0 3

COURSE OBJECTIVES:

Analyze energy extraction from non-conventional harvesting

sources.

Design and model energy harvesting materials.

Analyze the different sensor-level power supply architectures

COURSE OUTCOMES:


Design different types of Energy Harvesting sources.

Analyze the performance of energy sources.

UNIT I POWER MICROSYSTEMS WITH AMBIENT

ENERGY

9

Microsystems: Market Demand, Energy and Power requirements,

Technology Trends, Miniature Sources: Light Energy, Kinetic energy,

168

Thermal energy and Mechanical Energy, Conditioning Microelectronics:

Linear Switch, Switched Capacitors and Inductor, Energy Harvesting

Chargers and Power Supplies.

UNIT II ENERGY HARVESTING APPLICATIONS 9

Energy Harvesting : Types of Energy Harvesting Sources and Power

Ranges, Medical Implants, Powering Solutions for Human Wearable

and Implantable Devices, Multisource Self-Powered, Device Conception.

Thermoelectric Design - Optimization and Constraints, Thermal System

Design and Considerations in Thermoelectric Systems, Structural

Design and Considerations in Thermoelectric Systems.

UNIT III ENERGY SOURCES 9

Theory of Thin Film-Based Thermo-power Wave Oscillations,

Characterization, Thermo-power Wave Systems, Bi2Te3- and Sb2Te3-

Based Thermo-power Wave Systems, Comparison of Sb2Te3- and

Bi2Te3-Based Thermo-power Devices, Thermo-power Devices Based

on Al2O3and Terracotta Substrate, ZnO-Based Thermo-power Wave

Sources.

UNIT IV SOLAR CELLS 9

Polymer Solar Cells: Theory Considerations and Survey on Existing and

New Polymers, Polymer Solar Cells: Nano- Optics for Enhancing

Efficiency, Manufacturing Techniques: From Small - Scale to Large-

Scale Production, Theory of the Organic Solar Cell, Normal Structure

Solar Cells, Inverted Structure Solar Cells, Comparison between

Inverted and Regular Structures, Different Cathode and Anode

Interfacial Layers Used in Inverted Solar cells.

UNIT V PIEZO ELECTRIC MATERIALS AND MODELING 9

Piezoelectric MEMS, Preparation of Piezoelectric PZT Thin Films, Lead-

Free Piezoelectric Thin Films, Vibration Energy Harvesters, Energy

169

Transfer in PVEH Devices, Single Degree of Freedom Model of a PVEH,

Limit Based on Inertial Coupling, Stress – Based Limits,

Electromechanical Conversion, Electrical Energy Extraction,

Benchmarking.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Krzysztof Iniewski, Madhu Bahskaran “Energy Harvesting with

Functional Materials and Microsystems” CRC Press Edition. First

Edition, 2014. ISBN 978-1-4665-8725-0.

2. Yen Khang Tan “Energy Harvesting Autonomous Sensor Systems”

CRC Press Edition. First Edition, 2013. ISBN 978-1-4398-9273-2.

3. Niell Elvin : Advances in Energy Harvesting Methods”, Springer, 2013.

WEB REFERENCES:

1. http://www.holistic.ecs.soton.ac.uk/

2. www.energyharvesting.net/

15VDA03 EMBEDDED AND NETWORKING SYSTEMS L T P C

3 0 0 3

COURSE OBJECTIVES:

Analyze Co-Synthesis Of Real-Time Embedded Systems.

Analyze Power Management Frame Work.

COURSE OUTCOMES:


Analyze applications in Wireless Sensor Networks

170

Analyze various network systems.

UNIT I EVOLUTION OF DSP ARCHITECTURE AND CO-

SYNTHESIS OF REAL-TIME EMBEDDED SYSTEMS

9

Fixed point DSP – DSP Array processing – VLIW devices –Multi

Processing – Co-Synthesis and real time constraints – Co-Synthesis

frame work –Target Embedded System specification and solution

representation – Optimization and proposed Co-Synthesis model – PE

initialization –Dead line assignment – Processes and communication

event scheduling- Evaluation of architectural Co-Synthesis

UNIT II EMBEDDED SYSTEM CODE OPTIMIZATION AND

POWER CONSUMPTION

9

Methods For Non-Intrusive Dynamic Application Profiling And Soft Error

Detection: Dynamic Application Soft Error Detection – Area efficient

optimization for Dynamic Application – Power Aware optimization –

Software and Hardware Platforms – Methodology and Applications –

Code optimization impact on power consumption

UNIT III POWER MANAGEMENT FRAME WORK FOR RTOS

BASED EMBEDDED SYSTEM

9

Proposed RTOS Power Management Frame Work – Implementation of

RTOS – ACPI Frame work– Power Management policies – Power

Saving and real Time Ability – Core Mark – Multi Core bench marking –

Multibench Benchmark Suite-Application specific Benchmarking and

Bench mark characterization.

UNIT IV NETWORKING EMBEDDED SYSTEMS 9

Global Innovation – Digital Storage – Processing – Sensors –Displays –

Statistical Data Analyses – Autonomic systems – New network

paradigms – Business Eco systems – Internet with Things.

171

UNIT V OCTOPUS AND DELAY AWARE APPLICATIONS IN

WIRELESS SENSOR NETWORKS

9

Mathematical Preliminaries – Proposed Model –Clustering– Computing

Minimum Dominant Set – Selecting Gate ways – Cluster head and

External Gateway Link–Complexity – Proposed Network Structure–

Network Formation Algorithm – Numerical Analyses

TOTAL: 45 PERIODS

REFERENCES:

1. Gul N. Khan, Krzysztof Iniewski, “Embedded and Networking

Systems: Design, Software, and Implementation”, CRC Press 2013.

2. Glaf P.Feiffer, Andrew Ayre and Christian Keyold, “Embedded

Networking with CAN and CAN open”, Embedded System Academy

2005.

3. Frank Vahid, Givargis „Embedded Systems Design: A Unified

Hardware/Software Introduction, Wiley Publications.

4. James F Kurose, “Computer Networking: A Top – Down Approach

Featuring the Internet”, Addison Wesley, 2nd Edition 2002.

WEB REFERENCE:

1. https://www.cisco.com/web/solutions/trends/iot/embedded.html

2. http://web.mit.edu/eichin/www/embedded-kerberos.html

15VDA04 EXTREME ENVIRONMENT ELECTRONICS L T P C

3 0 0 3

COURSE OBJECTIVES:

Analyze different methods for simulation for extreme

environments

172

Analyze Semiconductor devices for extreme environments

Determine the modeling for Applications at extreme environments

COURSE OUTCOMES:


Modeling of circuits for Extreme environments

Analyze the circuits for reliability in Extreme environments

Verify the models and Analyze the faults of the circuits

UNIT I INTRODUCTION TO EXTREME ENVIRONMENT

ELECTRONICS

9

Physics of Temperature and Temperature's Role in Carrier Transport,

Overview of Radiation Transport Physics and Space Environments,

Interaction of Radiation with Semiconductor Devices, Orbital Radiation

Environments, Error Rate Prediction Methods, Monte Carlo Simulation of

Radiation Effects, Extreme Environments in Energy Production and

Utilization, Extreme Environments in Transportation.

UNIT II SEMICONDUCTOR DEVICE TECHNOLOGIES 9

Radiation Effects in Si CMOS Platforms, Wide Temperature Range

Operation of Si CMOS Platforms, Trade-Offs between Performance and

Reliability in Sub-100nm RF-CMOS on SOI Technologies, SiGe HBT

Platforms, Using Temperature to Explore the Scaling Limits of SiGe

HBTs, SiC Integrated Circuit Platforms for High-Temperature

Applications, Passive Elements in Silicon Technology, Power Device

Platforms, CMOS-Compatible Silicon-on-Insulator MESFETs for

Extreme Environments.

UNIT III MODELING FOR EXTREME ENVIRONMENT

ELECTRONIC DESIGN

9

TCAD of Advanced Transistors, Mixed-Mode TCAD Tools, Mixed-Mode

173

TCAD for Modeling of Single-Event Effects, Compact Modeling of SiGe

HBTs, Compact Modeling of CMOS Devices, Compact Modeling of

LDMOS Transistors, Compact Modeling of Power Devices, Modeling

Radiation Effects in Mixed-Signal Circuits, Compact Model Toolkits.

UNIT IV RELIABILITY AND CIRCUIT DESIGN FOR EXTREME

ENVIRONMENTS

9

Reliability Estimation of SiGe HBTs & Silicon CMOS, Radiation

Hardening by Design, RHBD Techniques for SiGe Devices and Circuits,

Wide Temperature Range Circuit Design, Invariability in Analog Circuits

Operating in Extreme Environments.

UNIT V VERIFICATION, PACKAGING AND EXTREME

ENVIRONMENT APPLICATIONS

9

Model-Based Verification, Event-Driven Mixed-Signal Modeling

Techniques for System-in-Package Functional Verification, Electronic

Packaging Approaches for Low & High -Temperature Environments,

Failure Analysis of Electronic Packaging, Silicon Carbide Power

Electronics Packaging, A SiGe Remote Sensor Interface and Remote

Electronics Unit, Distributed Motor Controller for Operation, Radiation-

Hard Multichannel Digitizer ASIC.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. John D. Cressler, H. Alan Mantooth, “Extreme Environment

Electronics”, CRC press, 2013.

2. N. DasGupta and A. DasGupta, “Semiconductor Devices – Modeling

and Technology”, Prentice Hall of India Pvt. Ltd, New Delhi, India,

2004.

3. A. B. Bhattacharyya, “Compact MOSFET Models for VLSI Design”,

John Wiley & Sons Inc., 2009.

174

WEB REFERENCES:

1. www.eng.auburn.edu/.../Extreme_Environment_Electronics_application

s

2. www.crcnetbase.com

15VDA05 TRANSDUCERS AND SIGNAL CONDITIONING

CIRCUITS

L T P C

3 0 0 3

COURSE OBJECTIVES:

Analyze different physical measurements

Analyze the different types of sensors

Evaluate the signal arrangements for sensor communications

COURSE OUTCOMES:


Analyze the resistive and reactive variations for different physical

measurements

Create interface the sensors with Processors

UNIT I SENSOR-BASED MEASUREMENT SYSTEMS 9

General Concepts and Terminology, Sensor Classification, General

Input & Output Configuration, Static Characteristics of Measurement

Systems, Dynamic Characteristics, Other Sensor Characteristics,

Primary Sensors, Materials for Sensors, Microsensor Technology.

UNIT II RESISTIVE SENSORS 9

Potentiometers, Strain Gauges, Resistive Temperature Detectors

(RTDs), Thermistors, Magneto resistors, LDRs, Resistive Hygrometers,

175

Resistive Gas Sensors, Liquid Conductivity Sensors, Measurement of

Resistance, Voltage Dividers, Wheatstone Bridge: Balance

Measurements, Wheatstone Bridge: Detection Measurements,

Differential and Instrumentation Amplifiers.

UNIT III REACTANCE VARIATION AND ELECTROMAGNETIC

SENSORS

9

Capacitive Sensors, Inductive Sensors, Electromagnetic Sensors,

Problems and Alternatives, AC Bridges, Carrier Amplifiers and Coherent

Detection, Specific Signal Conditioners for Capacitive Sensors,

Resolver-to-Digital and Digital-to-Resolver Converters, Synchro-to-

resolver converters, Digital-to-resolver converters, Resolver-to-digital

converters.

UNIT IV SELF-GENERATING SENSORS 9

Thermocouples, Piezoelectric Sensors, Pyroelectric Sensors,

Photovoltaic Sensors, Electrochemical Sensors, Chopper and Low-Drift

Amplifiers, Electrometer and Transimpedance Amplifiers, Charge

Amplifiers, Noise in Amplifiers, Noise and Drift in Resistors, Noise in

resistors

UNIT V DIGITAL AND INTELLIGENT SENSORS 9

Position Encoders, Resonant Sensors, Variable Oscillators, Conversion

to Frequency, Period, or Time Duration, Direct Sensor - Microcontroller

Interfacing, Communication Systems for Sensors, Intelligent Sensors,

Sensors Based on Semiconductor Junctions and MOSFET Junctions,

Fiber-Optic Sensors, Ultrasonic-Based Sensors, Biosensors.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Ramon Pallaas-Areny, John G. Webster “Sensors and Signal

176

Conditioning” John Wiley, Second Edition, 2007.

2. D.V.S Murty “Transducers and Instrumentation” Prentice Hall, First

Edition, 2004.

WEB REFERENCES:

1. www.engineersgarage.com/articles/sensors

2. www.sensorsmag.com

177

ALLIED ELECTIVES OFFERED BY CSE DEPARTMENT

ALLIED ELECTIVE

SL.

NO.

COURSE CODE


1 15MCA01 Data Structures 3 0 0 3

2 15MCA02 Introduction to Data Mining 3 0 0 3

3 15MCA03 Software Engineering Principles 3 0 0 3

4 15MCA04 Information Security 3 0 0 3

5 15MCA05 Internet Security 3 0 0 3

15MCA01 DATA STRUCTURES L T P C

3 0 0 3

Course Objectives:

To study data structures such as list, stack, queue and set along with its

applications

To learn nonlinear data structures such as Tree and Graph with

applications

To learn advanced search structures and heap structures and its

applications

To discuss sorting and searching techniques

To introduce concurrency on the basic data structures such as list, stack

and queue.

Course Outcomes:

Use linked lists, stacks, queues and sets for various applications

Use tree and Graph for real time applications

Design various types of search and heap structures

Apply appropriate sorting and searching algorithms for real world

applications

Design and implement concurrent linked lists, stacks, and queues

178

UNIT I LINEAR AND NON-LINEAR DATA STRUCTURES 9

List ADT: Array and linked List – Applications: Polynomial Operations, Multi list.

Stack ADT: Implementation – Applications: Balancing symbols. Queue ADT:

Implementation – Applications: Job/Task scheduling. Set ADT: Operations -

Union and Find – Smart union algorithms – Path compression – Applications of

set- Maze problem.

UNIT II TREE AND GRAPH STRUCTURES 9

Tree ADT– Binary trees – traversals – Expression Trees -– Applications of Tree

– Directory. Graph – Traversal – Shortest path algorithms: Single source

shortest path algorithm. Minimum spanning tree – Prim’s and Kruskal’s

algorithms – Finding Connected components - PERT graph

UNIT III SEARCH TREES AND HEAP STRUCTURES

Binary search trees - 2-D tree - Red Black tree– Splay trees - Multi-way Search

Trees – Tries. Priority queue – Min heap – Deaps - Applications of heap - Event

Simulation and selection.

UNIT IV SORTING AND SEARCHING 9

Bubble sort - Selection sort - Insertion sort –Bucket Sorting- Merge sort -Quick

sort – Heap sort. Linear Search– Binary Search - Introduction to hashing -

Hash tables – Separate chaining – Open addressing - ISAM

UNIT V DATA STRUCTURES AND CONCURRENCY 9

Data structures and concurrency – locking linked lists – coarse-grained

synchronization – fine-grained synchronization – lazy synchronization – non-

blocking synchronization – concurrent queues – bounded partial queues –

unbounded lock-free queues – dual data structures – concurrent stacks –

elimination backoff stack

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Mark Allen Weiss, “Data Structures and Algorithm Analysis in C”, 3rd

edition, Pearson Education Asia, 2007.

2. Jean-Paul Tremblay and Paul G. Sorenson, “An Introduction to Data

Structures with Applications”, Second Edition, Tata McGraw-Hill, New

Delhi, 1991.

3. M. Herlihy and N. Shavit, “The Art of Multiprocessor Programming”,

Morgan Kaufmann, 2012.

179

4. Gregory L. Heilman, “Data Structures, Algorithms and Object Oriented

Programming”, Tata Mcgraw-Hill, New Delhi, 2002.

5. Alfred V. Aho, John E. Hopcroft and Jeffry D. Ullman, “Data Structures

and Algorithms”, Pearson Education, New Delhi, 2006.

WEB REFERENCES:

1. http://www.geeksforgeeks.org/pattern-searching-set-8-suffix-tree-

introduction/

2. http://iamwww.unibe.ch/~wenger/DA/SkipList/

3. http://www.cs.au.dk/~gerth/slides/soda98.pdf

4. http://www.cs.sunysb.edu/~algorith/files/suffix-trees.shtml

5. http://pages.cs.wisc.edu/~shuchi/courses/880-S07/scribe-

notes/lecture20.pdf

15MCA02 INTRODUCTION TO DATA MINING L T P C

3 0 0 3

Course Objectives:

To study data mining, its applications and its issues

To learn to mine the data using Frequent Patterns

To discuss the various classification methods

To understand how to evaluate classification models and select the

appropriate one

To study the role of clustering on large data

Course Outcomes:

Identify the data mining tasks and the issues in data mining applications

Generate rules using association rule mining

Develop solutions using classification algorithms

Select the right classification technique and algorithm for the given

problem

Develop solutions using clustering techniques


Introduction to Data Mining – Types of Data Mining – Technologies for Data

180

Mining - Applications of Data Mining-Major Issues in Data Mining - Data sets –

Data Objects and Attributes- Measurement and Data- Data Pre-processing-

Data Visualization

UNIT II FREQUENT PATTERN MINING 9

Basic Concepts of frequent patterns - Frequent Itemset Mining Methods -

Evaluation of Interestingness - Pattern Mining in Multilevel, Multidimensional

Space - Mining High dimensional Data - Applications of Pattern Mining

UNIT III CLASSIFICATION 9

Basic Concept of classification – Decision Tree induction – Bayes Classification

Methods – Rule Based Classification - Model Evaluation and Selection –

Techniques to improve Classification Accuracy

UNIT IV ADVANCED CLASSIFICATION 9

Bayesian Belief Networks - Classification by Back Propagation – Support Vector

Machine – Classification using frequent patterns - k-Nearest -Neighbour

Classifiers - Genetic Algorithms - Rough Set Approach - Fuzzy Set Approach

UNIT V CLUSTER ANALYSIS 9

Basic concept of Cluster Analysis-Partitioning methods – Hierarchical methods

– Density Based Methods – Grid Based Methods – Evaluation of Clustering –

Advanced Cluster Analysis: Probabilistic model based clustering – Clustering

High Dimensional Data – Clustering Graph and Network Data

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Jiawei Han, Micheline Kamber, Jian Pei, “Data Mining: Concepts and

Techniques”, Third Edition, The Morgan Kaufmann Series in Data

Management Systems, 2012.

2. David J. Hand, Heikki Mannila and Padhraic Smyth, “Principles of Data

Mining”, MIT Press, 2001.

3. Margaret H Dunham, “Data Mining: Introductory and Advanced Topics”,

Pearson Education, 2003.

4. Soman K.P, Diwakar Shyam and Ajay V. “Insight into Data Mining:

Theory and Practice”, PHI, 2009.

5. I. H. Witten and E. Frank, “Data Mining: Practical Machine Learning

181

Tools and Techniques”, Second Edition, Morgan Kaufmann, 2005

WEB REFERENCES:

1. http://www.autonlab.org/tutorials

2. http://ocw.mit.edu/courses/sloan-school-of-management/15-062-data-

mining-spring-2003/index.htm

15MCA03 SOFTWARE ENGINEERING PRINCIPLES L T P C

3 0 0 3

Course Objectives:

To explain the process and process models

To bring out the requirements and prepare them into a model

To know the design concepts and testing strategies

To explain estimation and scheduling techniques

To learn the project management and quality principles

Course Outcomes:

Deploy an appropriate process model for the software

Identify the different requirements of a software and create a model

Convert the model into a deign and implement testing strategies

Prepare the software project estimate and schedule

Maintain the desired quality for the developed software

UNIT I SOFTWARE PROCESSSES AND PROCESS

MODELS

9

The Nature of Software – Software Engineering - The Software Process –

Software myths – Generic Process Models - Prescriptive Process Models : The

Waterfall Model, Incremental Process Model, Evolutionary Process Models –

Overview of Agile Process models – Overview of CMMi

UNIT II REQUIREMENTS ANALYSIS 9

Requirements Engineering – Eliciting requirements – Developing use cases –

Building requirements model – Negotiating requirements – Validating

requirements – Requirements analysis – Scenario based modelling

182

UNIT III DESIGN,CODING AND TESTING 9

Design Concepts – Design Model - Software Architecture: Architectural Styles,

Architectural Design, User Interface Design – Coding: Programming Principles

and Guidelines - Testing Strategies for conventional software– Validation testing

– System Testing – Debugging – White box tesing – Basis path testing – Control

structure testing – Black box testing

UNIT IV PROJECT ESTIMATION AND SCHEDULING 9

Project management spectrum – Process and Project Metrics : Metrics ,

Software measurements, Software quality metrics – Estimation: Project

planning process, Resources, Decomposition techniques, Empirical Estimation

models– Scheduling: Project Schedling, Tracking, Scheduling and Earned

value analysis

UNIT V SOFTWARE QUALITY 9

Risk management – Software Configuration Management – Quality

Management: Software quality, Achieving Software quality and Formal

Technical Reviews - Overview of Maintenance - Rengineering and reverse

engineering

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Roger S.Pressman, “Software Engineering – A practitioner’s Approach”,

McGraw Hill Publications, Seventh Edition, 2010.

2. Pankaj Jalote,”An Integrated Approach to Software Engineering”,

Springer, Third Edition, 2005.

3. Ian Sommerville, “Software engineering”, , Pearson Education Asia,

Seventh Edition , 2007.

4. Watts S.Humphrey, ”A Discipline for Software Engineering”, Pearson

Education, 2007.

5. James F.Peters and Witold Pedrycz, ”Software Engineering, An

Engineering Approach”, Wiley-India, 2007.

6. Stephen R.Schach, “Software Engineering”, Tata McGraw-Hill, 2007.

7. S.A.Kelkar, ”Software Engineering”, Prentice Hall of India Pvt, 2007.

8. Pankaj Jalote- “A Concise Introduction to Software Engineering”, Springer

Verlag, 2008.

183

WEB REFERENCES:

1. www.mhhe.com/pressman

2. www.rspa.com/spi/

3. http://www.wiley.com/college/comp/peters189642/

15MCA04 INFORMATION SECURITY L T P C

3 0 0 3

Course Objectives:

To understand the role of access control in information systems

To explain the cryptanalysis for various ciphers.

To exemplify the attacks on software and its solutions

To explore the operating system security mechanisms

To learn the methods to prevent the system and network intrusions

Course Outcomes:

Exercise the access control mechanism for better authentication and

authorization

Perform cryptanalysis for various ciphers.

Apply solutions to overcome the attacks on software

Deploy the various techniques to secure the operating systems

Develop solutions to guard against system and network intrusions

UNIT I ACCESS CONTROL 9

Authentication - Passwords – Biometrics - Two-factor Authentication –

Authorization - Access Control Matrix - Multilevel Security Model - Covert

Channel - Authentication Protocols - Perfect Forward Secrecy-Confidentiality

Policies - Integrity Policies - Hybrid Policies

UNIT II CRYPTANALYSIS OF CIPHERS 9

Classical Ciphers-Symmetric Key Ciphers-Stream Ciphers-Block Ciphers-Public

Key Ciphers-RSA-Diffie-Hellman-Linear and Differential Cryptanalysis-Tiny

DES-Linear and Differential Cryptanalysis of Tiny DES- Side Channel Attack on

RSA-Lattice Reduction and the Knapsack-Hellman's Time-Memory Tradeoff

184

UNIT III ATTACKS ON SOFTWARE 9

Software Flaws-Buffer Overflow-Incomplete Mediation-Race Conditions-

Malware-Software Based Attacks-Salami-Linearization-Time Bombs-Trusting

Software-Insecurity in Software-Software Reverse Engineering-Software

Tamper Resistance-Digital Rights Management-Software Development Issues

UNIT IV OPERATING SYSTEM SECURITY 9

Operating System Security Functions-Separation-Memory Protection-Access

Control-Trusted Operating System-MAC-DAC-Trusted Path-Trusted

Computing Base-Next Generation Secure Computing Base-Feature Groups-

Compelling Applications-Evaluating Systems: TCSEC,FIPS140,The common

Criteria, SSE- CMM

UNIT V SYSTEM AND NETWORK SECURITY 9

Preventing System Intrusions-Guarding against Network Intrusions-Identity

Management-identity Theft-Penetration Testing-Vulnerability Assessment

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Mark Stamp,"Information Security: Principles and Practice", John wiley &

Sons, 2006.

2. Matt Bishop,"Introduction to Computer Security", Pearson Education, First

Edition,2005.

3. John R.Vacca (Ed),"Computer and Information Security Handbook",

Morgan Kaufman, Second Edition, 2013.

4. Charles P.Pfleeger and Shari Lawrence Pfleeger, "Security in Computing

”, Prentice Hall, Fourth Edition, 2006

5. Michael Whitman,and Herbert Mattord “Principles of Information

Security”, Fourth Edition, Cengage Learning, 2012.

6. William Stallings, “Cryptography and Network Security: Principles and

Practices”, Pearson Education, Third Edition, 2011.

WEB REFERENCES:

1. http://www.itsecurity.com

2. http://security.harvard.edu

185

15MCA05 INTERNET SECURITY L T P C

3 0 0 3

Course Objectives:

To introduce the classical and modern block ciphers, the hash functions

and authentication protocols

To explore public key cryptosystems and key management techniques

To study various network security protocols.

To understand public key infrastructure and IPSec protocols

To exemplify E-commerce protocols

Course Outcomes:

Apply the modern block ciphers like DES, AES, hash functions and

Authentication Protocols

Use public key cryptosystems like RSA and ECC and key management

techniques

Make use of the network Security protocols like Kerberos, PGP and SSL

Formulate PKI and IPSec protocol

Implement security in E-Commerce using Secure Electronic Transactions

(SET) protocols

UNIT I CRYPTOSYSTEMS AND AUTHENTICATION 9

Classical Cryptography - Substitution Ciphers - permutation Ciphers - Block

Ciphers – DES - Modes of Operation – AES - Linear Cryptanalysis, Differential

Cryptanalysis - Hash Function – SHA-512 - Message authentication codes -

HMAC - Authentication protocols

UNIT II PUBLIC KEY CRYPTOSYSTEMS 9

Introduction to Public key Cryptography - Number theory - The RSA

Cryptosystem and Factoring Integer - Attacks on RSA - The ELGamal

Cryptosystem - Digital Signature Algorithm - Finite Fields - Elliptic Curves

Cryptography - Key management – Session and Interchange keys, Key

exchange and generation

UNIT III NETWORK SECURITY 9

186

Kerberos - Pretty Good Privacy (PGP) - S/MIME - Secure Socket Layer (SSL)

and TLSv3 - Intruders – HIDS - NIDS

UNIT IV PUBLIC KEY INFRASTRUCTURE 9

Internet Publications for Standards-Digital Signing Techniques-Functional

Roles of PKI entities-Key Elements of PKI operations-X.509 Certificate

Formats-Certificate Revocation List-Certification Path Validation-IPSec-IPSec

Authentication Header-IP Encapsulating Security Payload-Key Management

protocol for IPSec

UNIT V E-COMMERCE SECURITY 9

Secure Electronic Transactions (SET) - Cryptographic Operation principles -

Dual signature and signature verification - Payment Processing - Internet

Firewalls-Role of Firewalls-Types of Firewalls-Firewall Designs-Viruses

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. William Stallings, “Cryptography and Network Security: Principles and

Practices”, Third Edition, Pearson Education, 2006.

2. Wade Trappe and Lawrence C. Washington, “Introduction to

Cryptography with Coding Theory”, Second Edition, Pearson Education,

2007

3. Man Young Rhee, "Internet Security: Cryptographic Principles,

algorithms and Protocols", Wiley, 2003.

4. Douglas R. Stinson, “Cryptography Theory and Practice”, Third Edition,

Chapman & Hall/CRC, 2006.

5. Jeffery Hoffstein, Jill Pipher, Joseph H. Silverman, "An Introduction to

Mathematical Cryptography", Springer, 2008.

6. Bernard Menezes, "Network Security and Cryptography", Cengage

Learning, New Delhi, 2011

7. Jonathan Katz and Yehuda Lindell, "Introduction to Modern

Cryptography", CRC Press, 2007

187

WEB REFERENCES:

1. https://www.cryptool.org/

2. http://www.crypto-textbook.com/

ALLIED ELECTIVES OFFERED BY MECHANICAL ENGINEERING

DEPARTMENT

I. CAD / CAM

Sl.

No.

Subject

Code Course Title L T P C

1. 15CCA01 Work Design 3 0 0 3

2. 15CCA02 Mechatronics in Engineering Systems 3 0 0 3

II. Industrial Safety Engineering

1. 15ISA01 Industrial Noise Control 3 0 0 3

2 15ISA02 Handling of Nano powder 3 0 0 3

III. Nano Science and Technolgy

SL.

NO.

COURSE


1. 15NTA01 Bottom up synthesis of nanostructures 3 0 0 3

2. 15NTA02 Nano toxicology 3 0 0 3

3. 15NTA03 Synthesis and application of 3 0 0 3

188

SL.

NO.

COURSE


nanomaterials

4. 15NTA04 Top down manufacturing methods 3 0 0 3

15CCA01 WORK DESIGN L T P C

3 0 0 3

COURSE OBJECTIVES:

To acquire a sound knowledge on Productivity.

To learn about method study.

To know the work measurement and applied work measurement

techniques.

To design displays and controls.

COURSE OUTCOMES:

At the end of this course, the students are able to,

Demonstrate various productivity models.

Explain the graphic tools used in method study.

Calculate the standard time for different operations.

Calculate wages by using different wage incentive plans.

Design displays and controls by considering the ergonomics.

UNITI PRODUCTIVITY 9

Productivity - definition – importance - types of productivity – productivity

and living standards – factors affecting productivity - work design and

Productivity – Productivity measurement-Productivity models – case

studies.

189

UNITII METHOD STUDY 9

Definition of method study – significance - Total work content, Developing

methods – operation analysis, motion & micro motion study, graphic tools –

case studies.

UNITIII WORK MEASUREMENT 9

Need for work measurement – steps in work measurement - Stop watch

time study - Performance rating – methods - allowances: definition, need

and types, standard data-machining times for basic operations, learning

effect.

UNITIV APPLIED WORK MEASUREMENT 9

Methods time measurement (MTM) - Work sampling techniques -

organization and methods (O & M) - Wage incentive plans: need and types

– case studies.

UNITV ERGONOMICS 9

Definition - Human factors Engineering - human performance in physical

work –anthropometry - design of workstation - design of displays and

controls – case studies.

TOTAL: 45 PERIODS

REFERENCES:

1. Benjamin W.Niebel, “Motion and Time Study”, Richard, D. Irwin Inc.,

Seventh Edition, 2002.

2. “Introduction to work study”, ILO, 3rd edition, Oxford & IBH publishing,

2001.

3. Barnes, R.M. “Motion and Time Study”, John Wiley, 2002.

4. Bridger R.S. “Introduction to Ergonomics”, McGraw Hill, 1995.

190

15CCA02 MECHATRONICS IN ENGINEERING SYSTEMS L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the technologies behind modern mechatronic

systems.

To provide methodological fundamentals for the development of fully

automated system.

To develop a robotic or automated system project focusing on the

hardware and software integration.

To apply the acquired knowledge for developing a mechatronic

system.

COURSE OUTCOMES:

On completion of the course on Mechatronics in Manufacturing Systems,

the students will have gained the following learning outcomes:

To understand and proficiently apply the relevant sciences and

scientific methods to mechatronics engineering, to design solutions

to complex problems.

Identify, interpret and critically appraise current developments and

advanced technologies and apply them to mechatronics

engineering.

Analysis and synthesise the constraints posed by economic factors,

safety considerations, environment impacts and professional

standards on mechatronics engineering practice and use them to

inform professional judgements.

To determine, analyse and proficiently apply theoretical and

numerical analysis of phenomena to predict, design, control and

optimise the performance of mechatronics engineering systems.

To create the research, identify, conceptualise, investigate, and

191

interpret knowledge from modern engineering tools and techniques

to synthesise a coherent approach to the solution of a problem

and/or the design of a project.

UNIT I INTRODUCTION AND SENSORS, TRANSDUCERS

9

Introduction to Mechatronics - Systems - Mechatronics in Products -

Measurement Systems - Control Systems - Traditional design and

Mechatronics Design. Introduction to sensors - Performance Terminology -

Displacement, Position and Proximity - Velocity and Motion - Fluid

pressure - Temperature sensors - Light sensors - Selection of sensors -

Signal processing - Servo systems.

UNIT II SIGNAL CONDITIONING AND REAL TIME INTERFACING

9

Introduction – Elements of data acquisition and control system –

transducers and signal conditioning – devices for data conversion – data

conversion process – application software like lab view – data acquisition

case studies - Data acquisition and control case studies

UNIT III MICROPROCESSORS IN MECHATRONICS 9

Introduction - Architecture - Pin configuration - Instruction set -

Programming of Microprocessors using 8085 instructions - Interfacing

input and output devices - Interfacing D/A converters and A/D converters –

Applications - Temperature control - Stepper motor control - Traffic light

controller.

UNIT IV PROGRAMMABLE LOGIC CONTROLLERS 9

Introduction - Basic structure - Input / Output processing - Programming -

Mnemonics Timers, Internal relays and counters - Data handling - Analog

input / output - Selection of PLC.

192

UNIT V DESIGN AND MECHATRONICS 9

Designing - Possible design solutions - Case studies of Mechatronics

systems- autonomous mobile robot – wireless surveillance balloon –

Firefighting robot – Piezo sensors and actuators in cantilever beam

vibration control.

TOTAL: 45 PERIODS

REFERENCES:

1. W.Bolton “ Mechatronics” Pearson 5th Edition , Pearson 2013.

2. R.K.Rajput “Introduction to “Mechatronics “4th Edition S.Chand &

Co.,2014.

3. Michael B.Histand and David G. Alciatore, “Introduction to

Mechatronics and Measurement Systems", McGraw-Hill

International Editions, 1999.

4. Bradley, D.A., Dawson, D, Buru, N.C. and Loader, AJ,

"Mechatronics", Chapman and Hall, 1993.

5. Ramesh.S, Gaonkar, "Microprocessor Architecture, Programming

and Applications” Wiley Eastern, 1998.

6. Lawrence J.Kamm, “Understanding Electro-Mechanical

Engineering, an Introduction to Mechatronics", Prentice-Hall,

2000.

7. Ghosh, P.K. and Sridhar, P.R., 0000 to 8085, “Introduction to

Microprocessors for Engineers and Scientists ", Second Edition,

Prentice Hall, 1995.

8. DevdasShetty Richard A.Kolk “ Mechatronics – System Design”

Second Edition, Cengage learning, 2014.

WEB REFERENCE:

http://www.cs.Indiana.edu.

193

15ISA01 : INDUSTRIAL NOISE CONTROL

(Common to other PG Programmes)

L T P C

3 0 0 3

COURSE OBJECTIVES:

To provide in depth knowledge about industrial noise control.

To get an exposure about the basic terms and terminologies about

the noise and its source.

To analyse and to design the machineries and equipment in such a

way that noise may be controlled at source or path.

COURSE OUTCOMES:

Upon completion of the course the students will be able

To identify regulations related to noise measurement and control in

industries.

To acquire the basic concepts and knowledge about Noise and its

types.

To apply the knowledge on Industrial noise control by suitable

methods.

To carry out noise assessment in workplace.

To suggest and recommend suitable practical measures to reduce

noise at the workplace.

UNIT I Fundamentals of noise and regulations 9

Introduction, Types of noise, frequency, wavelength, amplitude, speed,

Sound fields, sound pressure, sound pressure level, addition, subtraction

and averaging decibel levels, noise dose level, Sound intensity, sound

power and sound power level, OSHA noise standards permissible

exposure level and action level, Health hazards and hearing protection

program, The noise pollution (Regulation and Control ) Rules, 2000, The

control of noise at work regulations 2005, The Supply of Machinery (Safety)

Regulations.

194

UNIT II Noise Measurement 9

Need for noise measurement, Concept of noise measurement, Anechoic

chambers, Reverberation chambers, Terminologies used in noise

measurement, Rules for noise measurement, Influence of instrument and

operator, Influence of environment, Filtering and weighting scales,

Frequency analysis, source identification, source directivity, sound field

characteristics, determining daily noise exposure, sound power level

estimation, survey approach, Contents of measurement report.

UNIT III Instrumentation for Noise measurement 9

Microphones–Piezoelectric, electric condenser, air condenser, Integrators,

Pre amplifiers, sound level meters, Noise dosimeter, serial analysing

instruments, Frequency analyser, real time analyser, Recorder, sound

pressure calibrator - Measuring noise exposure in the workplace - field

demonstration, Standards for the performance and testing of noise

measurement instruments.

UNIT IV Noise control 9

Noise risk assessment, Noise control policy, Noise control checklist,

Hierarchy of noise control–organisational control, workplace design, Low

noise machines, machine design, Enclosures, screens and barriers,

Refuges, Damping, isolation, silencers, active noise control, Distance,

maintenance, Noise control material, Sound absorption coefficient,

Common absorbers, foam, fibrous material, Helmholtz resonators,

Insulating material and its rating, installation of sound insulating materials –

Hearing protection selection, use, care and maintenance, special type of

protectors, over protection.

UNIT V Specific Noise Sources and Solutions 9

Jet and turbulence noise, jet noise reduction, Valve noise, Fluid flow

problems furnace and combustion noise, fan and compressor noise, duct-

borne noise, automotive noise control, Engine noise, transmission and gear

195

noise, Coal handling equipment, Boilers, cooling towers, noise control in

heating, Ventilating and air conditioning system, Case studies – Gas

turbine generator, process steam boiler fans, Printing and cutting press,

Concrete block making machine.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. “Controlling Noise at Work”, Health and Safety Executive, 2nd edition,

2005.

2. “Industrial Noise Control Manual” NIOSH, Revised edition, 1978.

3. Graham Orr. W., “Handbook of Industrial Noise control”, The

Bionetics Corporation Hampton, Virginia.

4. Nicholas P. Cheremisinoff, “Noise Control in Industry: A Practical

Guide “, Standards media, 2003.

5. Arnold P.G. Peterson, “Handbook of Noise Measurement” GenRad,

Inc., Ninth edition, 1980.

6. Randall F. Barron, “Industrial Noise Control and Acoustics”, Marcel

Dekker, Inc., 2003.

7. Istvan .L.Ver and Leo Beranek, “Noise and Vibration control

engineering”, John Wiley & Sons, Second edition, 2006.

8. Michael Moser, “Engineering Acoustics: A Handbook”, 2009.

9. Lewis H.Bell & Doughlas H.Bell, “Industrial Noise Control” Marcel

Dewcker, inc., 2nd edition, 1993.

15ISA02 : HANDLING OF NANO POWDER

L T P C

3 0 0 3

COURSE OBJECTIVES:

To know nano powder properties and their handling.

To know the processing and characterisation of metal powders.

To gain the knowledge on various test and apparatus applicable

196

in dust explosion.

To study the nano powder handling and material handling

equipment in industries.

To understand housekeeping procedures and pollution control

methodology.

COURSE OUTCOMES:

At the end of this course, the students are able to

Students can have the abilities to understand the classification

and to synthesis and characterise the nano powders.

Can have the knowledge regarding the usage and applications

of equipment such as SEM, AFM etc., used to characterise the

metal powders.

The students will be able to understand the various tests and

apparatus used in dust explosion evaluation.

They can know how to handle the hazardous materials and

the usage of different kind of handling equipment.

Students can have knowledge about good housekeeping and

various safety procedures to control pollution.

UNIT I PROPERTIES OF NANO POWDER AND

METHODS OF HANDLING

9

Properties of nano powders - Powder classification - physical, chemical,

thermal and other properties - Friction and Impact sensitivity – Toxicity –

Explosivity – Metallic powders – Manual, mechanical, automatic handling

methods.

UNIT II NANO POWDER HAZARDS 9

Electrostatic charges - charge distribution - energy released-type of

discharge - spark-carona -insulating powders - propagating brush

discharge - discharge in bulk lightning hazards in powder coating –

197

electroplating. Dust explosion - explosibility characteristics

Recognition of chemical hazards - dust, fumes, mist, vapour, fog, gases,

types, concentration, Exposure vs. dose, TLV - Methods of Evaluation,

process or operation description - Field Survey - Sampling methodology -

Industrial Hygiene calculations - Comparison with OSHAS Standard.

UNIT III IGNITION OF NANO POWDERS AND

DUST CONTROL

9

Ignition - minimum ignition energy - powder dispersion - spark, generation –

characteristics - pressure concentration - flammable gases - solvent vapour

-vapour clouds – decomposition - exothermic and endothermic reaction.

Dust: Definition – type – concepts – exposure – dispersion – control -

monitoring and measure-control of dust at the source - control approaches

and strategies -occupational related diseases, lead-nickel, chromium, coal

and manganese toxicity, their effects and prevention - local, systemic and

chronic effects, temporary and cumulative effects, carcinogens entry into

human systems - Housekeeping and environmental protection -

technological options for collection, treatment and disposal of hazardous

waste - Pollution control in process industries.

UNIT IV HAZARD ASSESSMENT AND

MEASUREMENT

9

Volume reference – resistivity of solids-powders in bulk - surface resistance

-static charge, conductivity – electric field, minimum Ignition energy -

Hartmann vertical tube apparatus - particulate measurement - air sampler -

dust monitor.

Sampling instruments – types - Measurement procedures - Instruments

Procedures - dust sample collection devices - personal sampling - Hazard

identification and assessment in the process industries.

UNIT V SAFETY IN NANO POWDER HANDLING 9

Safety measures in powder handling – loading and unloading – pneumatic

transfer – sieving - grinding and mixing – control measures – PPE -

198

earthing – elimination of incendiary discharge.

Dust Explosion prevention – handling of nano powders in the presence of

flammable gases and vapour – safety measures in industries.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Martin Glor, “Electro Static Hazard in Powder Handling” Research

studies Press Ltd., England, 1988.

2. Major Hazard Control-ILO Geneva, 1987.

3. Seminar on “Hazard Recognition and Prevention in the Work Place-

Airborne Dust” Vol.1 and 2, SRMC, Chennai, 4/5, Sept., 2000.

4. Hand book of “Occupational Safety and Health”, National Safety

Council, Chicago, 1982.

15NTA01

BOTTOM UP SYNTHESIS OF

NANOSTRUCTURES

L T P C

3 0 0 3

COURSE OBJECTIVES:

To provide synthetic approach about thin films.

Knowledge about physical vapour deposition on sputtering.

To know about epitaxial growth of semi-conductor films.

To have an idea about the development of thin film by chemical

methods.

To know about different printing technologies.

COURSE OUTCOMES:


To develop thin films using CVD and other methods.

To obtain thin films using sputtering methods.

199

To develop epitaxial growth of thin films.

To grow thin films using various chemical methods.

To differentiate different types of printing techniques.

UNIT I THIN FILM TECHNOLOGIES – I 9

CVD chemical vapor deposition – atmospheric pressure CVD (APCVD) –

low pressure CVD (LPCVD) - plasma enhanced chemical vapor deposition

(PECVD) - HiPCO method – photo-enhanced chemical vapor deposition

(PHCVD) - LCVD Laser – induced CVD.

UNIT II THIN FILM TECHNOLOGIES – II 9

Physical vapor deposition - sputter technologies - diode sputtering -

magnetron sputtering - ion beam (sputter) deposition, ion implantation and

ion assisted deposition - cathodic arc deposition - pulsed laser deposition.

UNIT III EPITAXIAL FILM DEPOSITION METHODS 9

Epitaxy, different kinds of epitaxy - influence of substrate and substrate

orientation, mismatch, MOCVD metal organic chemical vapor deposition -

CCVD combustion chemical vapor deposition - ALD atomic layer deposition

- LPE Liquid phase epitaxy - MBE molecular beam epitaxy.

UNIT IV CHEMICAL METHODS 9

Sol-gel synthesis – different types of coatings - spin coating - self-assembly

- (periodic) starting points for self-assembly - directed self-assembly using

conventional lithography - template self-assembly - vapor liquid solid

growth - langmuir-blodgett films – DNA self-assembly.

UNIT V PRINTING TECHNOLOGIES 9

Screen printing - inkjet printing - gravure printing and flexographic printing -

flex graphic printing - gravure printing – roll to roll techniques.

TOTAL: 45 PERIODS

200

REFERENCE BOOKS:

1. G. Cao, “Nanostructures & nano materials: Synthesis, properties &

applications” , Imperial college press, 2004.

2. W.T.S. Huck, “Nanoscale assembly: chemical techniques

(nanostructure science and technology)”, Springer, 2005.

3. E. Gdoutos and I. M. Daniel, “Handbook of nano science

engineering and technology”, Kluwer publishers, 2002.

15NTA02 NANOTOXICOLOGY L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand about fundamentals of toxicology.

To learn about risk on nano toxicology.

To gain knowledge about protocols in toxicology studies.

To learn the animal studies on toxicology.

To understand concepts on risk assessment and execution.

COURSE OUTCOMES:

Learn the toxicological terminology.

Gain knowledge about nano toxicity.

Ability to assess toxicity of nano materials.

Know about dosing profile for animal models.

Exposure on the regulations of toxicity.

UNIT I INTRODUCTION TO TOXICOLOGY 8

Concept of toxicology - types of toxicity based on route of entry - nature of

201

the toxin – toxicodynamics – dose Vs. toxicity relationships - toxicokinetics

– ADME - LADMET hypothesis - genotoxicity and carcinogenicity –

mechanisms and tests - organ toxicity – respiratory - dermal hepato -

neuro and nephro.

UNIT II NANO TOXICOLOGY 10

Characteristics of nanoparticles that determine potential toxicity - bio-

distribution of nanoparticles - interation of nanoparticles with biomembrane

and genes - evaluation of nanoparticle transfer using placental models -

nanomaterial toxicity – pulmonary – dermal – hepato – neuro - ocular and

nephron - estimation of nanoparticle dose in humans - in vitro toxicity

studies of ultrafine diesel exhaust particles; toxicity studies of carbon

nanotubes.

UNIT III PROTOCOLS IN TOXICOLOGY STUDIES 9

Methods for toxicity assessment – cyto, geno, hepato, neuro, nephrotoxicity

- assessment of toxicokinetics - assessment of oxidative stress and

antioxidant status.

UNIT IV ANIMAL MODELS 9

Types, species and strains of animals used in toxicity studies - dosing

profile for animal models - studies on toxicology - pathology and

metabolism in mouse and rat - laws and regulations - governing animal

care and use in research.

UNIT V RISK ASSESSMENT AND EXECUTION 9

Risk assessment of nanoparticle exposure - prevention and control of nano

particles exposure - regulation and recommendations.

TOTAL: 45 PERIODS

202

REFERENCE BOOKS:

1. John H. Duffus & Howard G. J. Worth, “Fundamental toxicology”, The

Royal Society of Chemistry, 2006.

2. Nancy A. Monteiro-Riviere & C. Lang Tran., “Nano toxicology:

characterization, dosing and health effect”, Informa healthcare

publishers, 2007.

3. Lucio G. Costa, Ernest Hodgson, David A. Lawrence, Donald J. Reed

& William F. Greenlee, “Current protocols in toxicology”, John Wiley &

Sons, Inc. 2005.

4. Shayne C. Gad, “Animal models in toxicology”, Taylor & Francis

Group, LLC 2007.

5. P. Houdy, M. Lahmani & F. Marano, “Nanoethics and

Nanotoxicology”, Springer-Verlag Berlin Heidelberg, 2011.

6. M.ZafarNyamadzi, “A Reference handbook of nanotoxicology”, 2008.

7. Andreas Luch, “Molecular, clinical and environmental toxicology

Volume 2: Clinical toxicology”, Birkhauser Verlag AG, 2010.

15NTA03

SYNTHESIS AND APPLICATION OF

NANOMATERIALS

L T P C

3 0 0 3

COURSE OBJECTIVES:

To provide the basic knowledge in nanomaterials.

To obtain the knowledge about the fabrication of nanomaterials.

To know about the CNT production.

To have an idea about the bulk synthesis of nanomaterials.

To know about different applications of nanomaterials.

203

COURSE OUTCOMES:


To know basic knowledge on nanomaterials.

To synthesis nanomaterials using physio, chemical approaches.

To fabricate CNT and its properties, applications.

To gain knowledge on bulk synthesis of nano materials.

To apply nanomaterials for various applications.

UNIT I FUNDAMENTALS OF NANOMATERIALS 9

Scientific revolutions - Nano sized metals and alloys, semiconductors,

ceramics - comparison with respective bulk materials - Zero, one, two, and

three dimensional nanostructures - surface area and aspect ratio - Size and

shape dependent optical, emission, electronic, transport, photonic,

refractive index, dielectric, mechanical, magnetic, non-linear optical

properties - Catalytic and photo catalytic properties.

UNIT II CHEMICAL & PHYSICAL APPROACHES 9

Sol gel process - Electro spraying and spin coating - SAMs - LB films -

micro emulsion polymerization - pulsed electrochemical deposition -

epitaxial growth techniques (CVD, MOCVD, MBE) - pulsed laser deposition

- Magnetron sputtering – lithography.

UNIT III CNT FABRICATION 9

Laser evaporation - carbon arc method - Chemical vapour deposition –

PECVD - Solid state formation of CNT - Flame synthesis - Mechanism of

growth - Purification - Fullerene and Graphene.

UNIT IV BULK SYNTHESIS 9

High energy ball mill - types of balls - ball ratio - medium for grinding -

204

limitations - severe plastic deformation - melt quenching and annealing -

Mechano chemical process - Bulk and nano composite materials.

UNIT V APPLICATIONS OF NANOMATERIALS 9

Field emission - Fuel Cells - Display devices - chemical & biological

sensors - Automobile - composite materials - space elevators - Electron

and Probe microscopy - Nanoporous Materials - AgX photography - smart

sunglasses - transparent conducting oxides - molecular sieves –

nanosponges.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. A. Roth, Vacuum technology, North – Holand Pub., II Edition,

1982.

2. S.P. Gaponenko, Optical Properties of semiconductor nanocrystals,

Cambridge University Press, 1980.

3. W.Gaddand, D.Brenner, S.Lysherski and G.J.Infrate(Eds.),

Handbook of NanoScience, Engg. and Technology, CRC Press,

2002.

4. K. Barriham, D.D. Vedensky, Low dimensional semiconductor

structures:fundamental and device applications, Cambridge

University Press, 2001.

5. G. Cao, Nanostructures & Nanomaterials: Synthesis, Properties

&Applications, Imperial College Press, 2004.

6. J.George, Preparation of Thin Films, Marcel Dekker, Inc., New

York. 2005.

205

15NTA04

TOP DOWN MANUFACTURING METHODS L T P C

3 0 0 3

COURSE OBJECTIVES:

To provide the basic knowledge in lithographic techniques.

To obtain the knowledge about advanced lithographic techniques.

To know about etching process followed after lithography.

To have an idea about the development of nano crystalline ceramics

using ball mill.

To know about different micro milling processes.

COURSE OUTCOMES:


To develop various lithography with etching techniques.

To advance knowledge on E-beam and ion beam lithography.

To develop ball milling processes to fabricate nano crystalline

materials.

To gain knowledge on micro milling/machining techniques.

To differentiate the types of micro milling processes.


Introduction to micro fabrication and Moore’s law – importance of

lithographic techniques - different types of lithographic techniques - optical

projection lithography – photo mask - binary mask - phase shift mask -

optical immersion lithography - maskless optical projection lithography -

zone plate array lithography - extreme ultraviolet lithography.

15ma176

206

UNIT II

E-BEAM AND ION BEAM LITHOGRAPHY

15

Principle and instrumentation - scanning electron-beam lithography - mask

less EBL - parallel direct-write e-beam systems - E-beam projection

lithography - X-ray lithography - focused ion beam lithography - ion

projection lithography - masked ion beam direct structuring – nano imprint

lithography - soft lithography - dip-pen lithography.

UNIT III ETCHING TECHNIQUES 5

Reactive ion etching - magnetically enhanced RIE - ion beam etching - wet

etching of silicon - isotropic etching - anisotropic etching - electrochemical

etching - vapor phase etching - dry etching - other etching techniques.

UNIT IV BALL MILLING TECHNIQUE 5

Nano powders produced using micro reactors – nano crystalline ceramics

by mechanical activation - formation of nanostructured polymers.

UNIT V MACHINING PROCESSES 8

Micro milling/micro drilling/micro grinding processes and the procedure for

selecting proper machining parameters with given specifications - EDM

micro machining, laser micro/nano machining - models to simulate

micro/nano machining processes using molecular dynamics techniques -

wet chemical etching - dry etching - thin film and sacrificial processes.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. M. J. Jackson, “Micro fabrication and nano manufacturing”, CRC

Press, 2005.

2. P.Rai-Choudhury, “Handbook of micro lithography, micro

machining, and micro fabrication”, Vol. 2, SPIE Press, 1997.

207

3. M. Madou, “Fundamentals of micro fabrication,” CRC Press, 1997.

4. G.Timp, “Nano technology”, AIP press, Springer-Verlag, New York,

1999.

ALLIED ELECTIVE OFFERED BY IT DEPARTMENT

SL.

NO

COURSE

CODE


1. 15MIA01 Embedded Computing Systems 3 0 0 3

2. 15MIA02 Scilab Programming 3 0 0 3

3. 15MIA03 Network Simulation 3 0 0 3

4. 15MIA04 Geo Information Systems 3 0 0 3

5. 15MIA05 Fuzzy Logic 3 0 0 3

6. 15MIA06

Statistical Analysis using R

Programming 3 0 0 3

7. 15MIA07 Sensor Networks 3 0 0 3

8. 15MIA08 Concurrent Programming 3 0 0 3

9. 15MIA09 Video Processing using OpenCV 3 0 0 3

10. 15MIA10

Rural Technology and Community

Development 3 0 0 3

11. 15MIA11 Pedagogy 3 0 0 3

12. 15MIA12 IT Essentials 3 0 0 3

208

15MIA01 EMBEDDED COMPUTING SYSTEMS L T P C

3 0 0 3

COURSE OBJECTIVES:

To gain knowledge about various processors, its architecture,

instruction set and its programming

To learn about memory and I/O Devices, its interfacing and handling

of interrupts

To learn more about multiple task and processes ,

To develop embedded software both in assembly language and C

To know about software development tools

COURSE OUTCOMES:

Develop 8051 and ARM Assembly Program

Analyze the need of memory and I/O management and to illustrate

the mechanism for handling the interrupts

Design the Processes suitable for embedded system.

Develop Embedded Software by considering real time constraints and

multi state sequences.

Design embedded systems for any application.

UNIT I Embedded Computing 9

Introduction-Embedded System design process-Formalism for System

Design-Instruction Sets-Preliminaries-ARM Processor-8051 Micro

Controller: Architecture, Instruction Sets and Programming

UNIT II MEMORY AND INPUT / OUTPUT MANAGEMENT 9

Programming Input and Output –Supervisor Modes, Exceptions, Trap, Co-

Processors- Memory system mechanisms –CPU Performance-CPU Power

Consumption- Memory and I/O devices– Interrupts handling.

209

UNIT III PROCESSES AND OPERATING SYSTEMS 9

Multiple tasks and processes –Preemptive Real Time Operating Systems–

Scheduling policies – Inter process communication mechanisms –

Performance issues-Power Management and Optimization for Processes

UNIT IV EMBEDDED SOFTWARE DEVELOPMENT 9

Programming embedded systems in assembly and C – Meeting real time

constraints – Multi-state systems and function sequences -Host and target

machines, linkers, locations for embedded software, getting embedded

software into target system, debugging technique

UNIT V SYSTEM DESIGN DEVOLPMENT 9

Design methodologies-requirement analysis-specifications- system analysis

and architecture design –Design examples- Telephone Answering

Machine- ink jet printer- water tank monitoring system-GPRS, Intruder

Alarm System- A Prototype Integrated Monitoring System for Pavement and

Traffic Based on an Embedded Sensing Network

TOTAL: 45 Periods

REFERENCE BOOKS:

1. Wayne Wolf, “Computers as Components: Principles of Embedded

Computer System Design”, Elsevier, Third Edition,2008.

2. Michael J. Pont, “Embedded C”, Pearson Education, Second

Edition,2008.

3. Steve Heath, “Embedded System Design”, Elsevier, 2005.

4. Muhammed Ali Mazidi, Janice Gillispie Mazidi and Rolin D. McKinlay,

“The 8051 Microcontroller and Embedded Systems”, Pearson

Education, Second edition, 2007.

5. David E.Simon, “ An Embedded Software Primer” pearson education,

2009

6. Wenjing Xue, Linbing Wang, and Dong Wang ,”A Prototype Integrated

Monitoring System for Pavement and Traffic Based on an Embedded

Sensing Network”, IEEE Transactions On Intelligent Transportation

Systems,June 2015

210

WEB REFERENCES:

1. www.scribd.com/doc/52569374/55/Busy-Wait-I-O

2. www.ict.kth.se/courses/2B1445/Lectures/Lecture3/2B1445_L3_CPU.p

df

3. www.webster.cs.ucr.edu/AoA/.../MemoryArchitecturea2.html

4. www.dce.kar.nic.in/new%20files/Chapter4-9-07.pdf

15MIA02 SCILAB PROGRAMMING

L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the fundamental structure and use of Scilab's

To give a description of the Scilab's existing functions, including the

integrated graphics facilities

To describes the main Scilab functions for system analysis and

control

To discuss the signal-processing tools, which include discussions

on signal representation, FIR and IIR filter design and spectral

estimation

To acquire the knowledge in simulation and optimization tools

To introduce various models used for simulation and optimization

problems

To describe Metanet, a toolbox for graphs and network flow

computations.

Introduce the student to the topic and to aid the professional in

making effective use of Scilab in the application area

COURSE OUTCOMES:

Use SCILAB tool and write simple programs

211

Create new functional Scilab primitives

Apply Scilab tool for various scientific and engineering problems

Apply Scilab's numerical solver for Ordinary Differential Equations

and Differential Algebraic Equations systems

Identify the way graphs are represented in Metanet and the

corresponding data structures

Solve several complex real-world problems

UNIT I SCILAB LANGUAGE AND GRAPHICS 9

Constants, Data types, Scilab Syntax, Data-Type-Related –Functions, Overloading, Graphics.

UNIT II BASIC FUNCTIONS AND ADVANCED

PROGRAMMING

9

Linear Algebra, Polynomial and Rational function Manipulation, Sparse

Matrices, Random Numbers, Cumulative Distribution Functions and their

Inverses.

Functions and Primitives- Call function- Building Interface Programs-

Accessing Global variables within a Wrapper- Intersci- Dynamic Linking-

Static Linking- GUI.

UNIT III SYSTEMS, CONTROL TOOLBOX AND

SIGNAL PROCESSING

9

Linear Systems- System Definition- Improper Systems- System

Operations- Control Tools- Classic Control- State-Space control-H

Control- Model Reduction- Identification- Linear matrix Inequalities.

Signal Processing: Time and frequency representation of signals-

Filtering and Filter design- Spectral Estimation.

UNIT IV SIMULATION AND OPTIMIZATION TOOLS 9

Simulation and Optimization Tools: Models- Integrating Ordinary

Differential Equations- Integrating Differential Algebraic Equations -

Solving optimization Problems.

212

Graph and Network Toolbox (Metanet): Graph- Representation Graphs-

Creating and Loading Graphs- Generating Graphs and Networks- Graph

and Network Computations- Examples using Metanet.

UNIT V APPLICATIONS 9

Modeling and Simulation of an N-Link pendulum -Modeling and

Simulation of a Car- Open-Loop Control to Swing Up a Pendulum-

Parameter Fitting and Implicit Models- Implementation of Genetic

Algorithm.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Claude Gomez “Engineering and Scientific Computing with Scilab”

Springer Science and Business Media Newyork 1999

2. Stephen L. Campbell, Jean-Philippe Chancelier and Ramine

Nikoukhah “Modeling and Simulation in Scilab/Scicos”, 2006

Springer Science Business Media,Inc

3. Rietsch E “An introduction to SciLab from a Matlab User's Point of

View”,2001, Eike Rietsch

WEB REFERENCES:

1. http://www.blogdopapeleiro.com.br/biblioteca/AplicativosLivres/Scil

ab/tutorial-all.pdf

2. http://www.scilab.org/content/search?SearchText=introscilab

3. www.cmap.polytechnique.fr/~allaire/levelset/manual.pdf

ftp.tuwien.ac.at/comp/scilab/manual_scilab-5.1.1_en_US.pdf

213

15MIA03 NETWORK SIMULATION L T P C

3 0 0 3

COURSE OBJECTIVES:

To explain the principles of functioning of the computer simulators.

To provide an understanding of the principles of computer

simulation as applied to computer networks.

To ensure that students can apply obtained knowledge and

effectively use relevant tools.

To Design computer network models for the simulator.

To investigate dynamic behaviour of the computer networks using

network simulator.

To process and critically analyse the data produced by network

simulator.

COURSE OUTCOMES:

Extrapolate the simulation of computer networks

Infer the linkage between TCL and OTCL programming

Paraphrase the basics of discrete event simulation

Simulate nodes as routers using ns2 modules

Construct ns2 scenarios that simulate various emerging types of

wired and wireless networks.


Simulation of computer networks - Layering concept- System modeling-

Simulation Definition- Elements of simulation-Time dependent

simulation –Protocols – Ns2: introduction - Architecture – installation –

directories – running ns2 simulation – including c++ module - Simulation

example – single channel queuing system

214

UNIT II TCL/OTCL PROGRAMMING 9

Linkage between OTcl and C++ - class binding – variable binding –

Variables – List - Procedure - Array - Conditional statements - Looping

Structures - Classes and objects – Expressions - File handling -

Input/output Console

UNIT III DISCRETE EVENT SIMULATION 9

Ns2 simulation concept - events and handlers – overview – class –

NSobject – Packet – At event - scheduler – components – data

encapsulation – polymorphism – main and auxiliary functions –

dynamics – scheduling – dispatching events – simulator – components –

retrieving – instance – initialization – instprocs - network objects-

creation, configuration and packet forwarding

UNIT IV SIMULATION OF NODES AS ROUTERS 9

Nodes – overview – multi-target packet forwarders – components – port

classifiers – hash classifiers – creating own classifiers – routing

modules – overview – c++ class routing module – Otcl routing module –

built-in routing module – route logic – node construction and

configuration

UNIT V SIMULATION EXAMPLES 9

WIRED SCENARIO - Simulator Class- Trace the events- Node creation-

Link between nodes- Communication Agent- Traffic agent - MAC

protocols – Ethernet - Simulation using NS2 - Wired-Cum-Wireless

Scenario - Creating Simple Wired-Cum-Wireless Scenario - Running

Mobile-Ip In Wired-Cum-Wireless Topology - Wireless Scenario - Node

Configuration- Routing Protocols- Energy Model- Topology Generation-

Graphical Events On Node- Neighbour Discovery- Route Discovery-

Event Scheduling Wireless Sensor Networks - Energy Model- Sense

Power-Transmission Power-Energy Efficient Routing Protocols-

Clustering

TOTAL: 45 PERIODS

215

REFERENCE BOOKS:

1. Teerawat Issariyakul, Ekram Hossain, “Introduction to Network

Simulator NS2”, Springer, Second Edition, 2012

2. Patel Rajankumar, Patel Nimisha, “A Case Study of Implementation

and Simulation of New Protocol in NS2: The PING Protocol for

MANET Environment”, International Conference on Computing for

Sustainable Global Development (INDIACom), 2014.

3. MIAO Quan-xing and XU Lei, “DYMO Routing Protocol Research

and Simulation Based on NS2”, 2010 International Conference on

Computer Application and System Modeling (ICCASM), 2010.

WEB REFERENCES:

1. http://www.isi.edu/nsnam/ns/

2. http://nile.wpi.edu/NS/

3. http://csis.bits-pilani.ac.in/faculty/murali/resources/tutorials/ns2.htm

4. http://www.winlab.rutgers.edu/~zhibinwu/html/network_simulator_2.html

5. http://wing.nitk.ac.in/tutorials/

15MIA04 GEOGRAPHIC INFORMATION SYSTEM L T P C

3 0 0 3

COURSE OBJECTIVES:

To provide exposure to data models and data structure used in

GIS

To introduce various Raster and Vector Analysis capabilities of

GIS

To expose the concept of quality and errors in GIS

COURSE OUTCOMES:

Explore the basics of GIS

Interpret different data models in GIS

216

Analyze the Raster data and vector data analysis

Apply different models in GIS

Apply data quality analysis in GIS

UNIT I BASICS 9

Maps: Types – Characteristics – Coordinate systems – Map projections

– Definition of GIS – Evolution – Components of GIS – Data : Spatial

and Non-spatial – Spatial Data: Point, Line, Polygon/Area and Surface

– Non-Spatial Data: Levels of measurement – Database Structures

UNIT II DATA MODEL AND INPUT 12

Raster Data Model – Grid – Tessellations – Geometry of Tessellations

–– Data Compression – Vector Data Model – Topology – Topological

consistency – Vector data input– Raster Vs. Vector comparison – File

Formats for Raster and Vector – Vector to Raster conversion- raster

formats

UNIT III DATA ANALYSIS AND OUTPUT 6

Raster Data Analysis: Local, Neighbourhood and Regional Operations

– Map Algebra – Vector Data Analysis: Non-topological analysis,

Topological Analysis - Point-in-Polygon - Line-in-polygon - Polygon-in-

polygon – Network Analysis – buffering – ODBC – Map Compilation.

UNIT IV SPATIAL MODELING 9

Modeling in GIS – types – Digital Elevation Models: Generation -

Representation, Applications – ALTM.

UNIT V DATA QUALITY AND MISCELLANEOUS

TOPICS

9

Data quality analysis – Sources of Error – Components of Data Quality

– Meta Data – Open GIS consortium – Customisation in GIS – Object

Oriented GIS – WebGIS-GIS system evaluation and bench marking

TOTAL: 45 Periods

217

REFERENCE BOOKS:

1. Lo. C P and Yeung, Albert K W, “Concepts and Techniques of

Geographic Information Systems”, Prentice Hall of India, 2012

2. Robert Laurini and Derek Thompson, “Fundamentals of Spatial

Information Systems”, Academic Press, 1996.

3. Peter A Burrough, Rachael A Mc.Donnell, “Principles of GIS”,

Oxford University Press, 2000.

4. Allan Brimicombe, GIS Environmental Modeling and Engineering,

Taylor & Francis, 2003.

WEB REFERENCES:

1. bgis.sanbi.org/gis-primer/page_15.htm

2. www.isprs.org/caravan/documents/Lao_GIS.pdf

3. planet.botany.uwc.ac.za/NISL/GIS/GIS_primer/page_25.htm

15MIA05 FUZZY LOGIC L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the basic knowledge of crisp and fuzzy sets

To learn basic knowledge of fuzzy information representation and

processing

To choose basic fuzzy inference and approximate reasoning and

the basic notion of fuzzy rule base

To know the basics of fuzzy relations

To learn basic fuzzy system modelling methods

COURSE OUTCOMES:

Identify the difference between the crisp set and fuzzy set concepts

Perform mapping of fuzzy sets by a function

Apply fuzzy inference systems in the design of intelligent systems.

Perform classification and clustering using fuzzy relations

218

Design the fuzzy logic controllers for various applications


Introduction - The Case for Imprecision - A Historical Perspective - The

Utility of Fuzzy Systems - Limitations of Fuzzy Systems - The Illusion:

Ignoring Uncertainty and Accuracy - Uncertainty and Information - Fuzzy

Sets and Membership - Chance Versus Fuzziness - Sets as Points in

Hypercubes - Classical Sets - Fuzzy Sets.

UNIT II CLASSICAL RELATIONS AND FUZZY

RELATIONS

9

Cartesian Product - Crisp Relations – Fuzzy Relations - Tolerance and

Equivalence Relations - Fuzzy Tolerance and Equivalence Relations-

Value Assignments-Other Forms of the Composition Operation-

Features of the Membership Function - Various Forms - Fuzzification -

Defuzzification to Crisp Sets - λ-Cuts for Fuzzy Relations- Defuzzification

to Scalars

UNIT III LOGIC AND FUZZY SYSTEMS 9

Classical Logic – Proof - Fuzzy Logic - Approximate Reasoning - Other

Forms of the Implication Operation – Fuzzy System - Natural Language

- Linguistic Hedges - Fuzzy (Rule-Based) Systems - Graphical

Techniques of Inference

UNIT IV FUZZY CLASSIFICATION 9

Classification by Equivalence Relations - Crisp Relations - Fuzzy

Relations - Cluster Analysis - Cluster Validity - c-Means Clustering -

Hard c-Means (HCM) - Fuzzy c-Means (FCM) - Classification Metric -

Hardening the Fuzzy c-Partition - Similarity Relations from Clustering

219

UNIT V FUZZY LOGIC CONTROL 9

Fuzzy reasoning – Mechanism – Mamdani’s Direct Method - Designing

Fuzzy Logic Controllers – Application Examples of Fuzzy Reasoning -

Simple Fuzzy Logic Controllers - Aircraft Landing Control Problem -

Classical Feedback Control - Fuzzy Logic for Adaptive Instruction in an

E-learning Environment for Computer Programming

TOTAL: 45 Periods

REFERENCES

1. Timothy J.Ross , “Fuzzy Logic with Engineering Applications”, Third

Edition , Wiley Publication, 2012

2. S. N. Sivanandam & S. N. Deepa, Principles of Soft Computing, Wiley

- India, 2007.

3. S. Rajasekaran & G.A. Vijayalakshmi Pai, “Neural Networks, Fuzzy

Logic and Genetic Algorithm: Synthesis and Applications” Prentice Hall

of India ,2003

4. Jyh-Shing Roger Jang, Chuen-Tsai Sun, Eiji Mizutani, “Neuro-Fuzzy

and Soft Computing”, Prentice-Hall of India, 2003.

5. Kazuo Tanaka ,“An Introduction to Fuzzy Logic for Practical

Applications”, Springer 1997

6. George J. Klir and Bo Yuan, “Fuzzy Sets and Fuzzy Logic-Theory and

Applications”, Prentice Hall, 1995.

7. Chrysafiadi, K, Virvou, M, “Fuzzy Logic for Adaptive Instruction in an

E-learning Environment for Computer Programming”, IEEE

transactions on Fuzzy Systems, Vol.23 No.1, Pages 164 -171, 2015.

WEB REFERENCES:

1. www.csie.ntnu.edu.tw/~violet/FT96/Ch1.ppt

2. www.csee.wvu.edu/classes/cpe521/old/01%20-

%20Introduction.ppt

3. www.pafkiet.edu.pk/Portals/0/.../Fuzzy_Systems_and_Application

s.ppt

220

15MIA06 STATISTICAL ANALYSIS USING R L T P C

3 0 0 3

COURSE OBJECTIVES:

Explore the need of R tool

Apply various Data Importing techniques in R

Implement programs with R with objects, functions, analysis etc

Work on applications, implementing R Analytics to create Business

Insights

Apply graphics interface in R

COURSE OUTCOMES:

Apply the basics of R programming

Apply the package concepts in R

Explore data analysis with objects and computation

Use classes and functions in R

Implement graphics with R

UNIT I INTRODUCTION TO R 9

Starting R – Installation – Data objects in R – Data Import and Export –

Data Manipulation – Computing with data – Organizing an analysis –

Language – Functions and Packages

UNIT II PROGRAMMING WITH R & PACKAGES 9

Commands to Functions – Functional Programming – Function objects –

Function calls – Language – Debugging – Errors and Warnings -

Package concept and tools – Why to write a package – Creating a

package – Documentation for Packages – Testing – Packaging

namespace – Including C in packages

UNIT III OBJECTS & DATA COMPUTATION 9

Objects, Names, and REFERENCES – Replacement Expressions –

221

Environments – Non-local Assignments – Closures – Connections –

Reading and Writing Objects – Object Types – Vector and Structures –

Vectorizing Computations – Statistical Data: Data Frames –

Computations on Numeric Data – Matrix Computations – Fitting

Statistical models – Programming Random Simulations

UNIT IV CLASSES & GENERIC FUNCTIONS 9

Why classes – Programming with classes – Inheritance and Inter-class

Relations – Virtual Classes – Creating and Validating Objects – Example

: Binary Trees – Data Frames – Why methods – method definitions –

methods for old functions – Programming techniques – Generic

functions – working of method selection

UNIT V WORKING OF R & GRAPHICS 9

R Program - Calls to R functions – Primitive Functions – Data

Visualization and graphics – xy plot – Common graphics model –

graphics package – Computing with Text – Import – Data analysis &

Computations – examples

TOTAL: 45 Periods

REFERENCE BOOKS:

1. John Chambers, “Software for Data Analysis: Programming with R

“, Springer; 1st ed. 2008. , 2nd printing 2009 edition

2. Torsten Hothorn, Brian S. Everitt, “ A Handbook of Statistical

Analyses Using R “,Chapman and Hall/CRC; 2 edition ,2009

3. Thomas Lumley,” Complex Surveys: A Guide to Analysis Using R”,

Wiley Series in survey methodology, 2010

4. Nicholas J. Horton, Ken Kleinman,” Using R and RStudio for Data

Management, Statistical Analysis, and Graphics” , CRC Press,

Second edition, 2015

5. Eric D. Kolaczyk, “Statistical Analysis of Network Data with R”,

Springer, 2014

6. John Maindonald, W. John Braun,”Data Analysis and Graphics

http://www.amazon.in/s/ref=rdr_ext_aut?_encoding=UTF8&index=books&field-author=Torsten%20Hothorn

http://www.amazon.in/s/ref=rdr_ext_aut?_encoding=UTF8&index=books&field-author=Brian%20S.%20Everitt

222

Using R: An Example-Based Approach”, University Press,

Cambridge, Third edition, 2010

7. John M. Quick,” Statistical Analysis with R”, Packt Publishing ,

2010

WEB REFERENCES:

1. http://www.gardenersown.co.uk/Education/Lectures/R/

2. http://www.ats.ucla.edu/stat/r/

3. http://www.statistics.com/r-for-statistical-analysis/

4. http://www.r-project.org/about.html

5. http://www.revolutionanalytics.com/what-r

15MIA07 SENSOR NETWORKS L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the fundamentals and Architecture of Wireless

Sensor Networks(WSN)

To analyze the role of physical and data link layer and its

associated protocols

To learn the impact of Time Synchronization, localization and

positioning in WSN

To understand the role of routing protocols in WSN

To apply concepts of WSN for real time applications

COURSE OUTCOMES:

Explore the impact the WSN and its associated hardware

components

Analyze the different protocols in MAC and Link layer

Apply the concepts of localization, Time synchronization and

positioning in WSN

Perform data routing and data aggregation

223

Design simple applications using sensor nodes incorporating

security features

UNIT I 8

Challenges for Wireless Sensor Networks- Enabling Technologies For

Wireless Sensor Networks- Single-node architecture-Hardware

components-Energy consumption of sensor nodes-Some examples of

sensor nodes-Network architecture-Sensor network scenarios-

Optimization goals and figures of merit-Design principles for WSNs

UNIT II 9

Physical layer-Wireless channel and communication fundamentals-

Transceiver design considerations in WSNs-MAC protocols-

Fundamentals-Low duty cycle protocols and wakeup concepts-

Contention-based protocols-Schedule-based protocols-The IEEE

802.15.4 MAC protocol-Link-layer protocols – Fundamentals - Error

control – Framing - Link management

UNIT III 10

Time Synchronization –Introduction- Protocols- Localization and

Positioning – Properties – mathematical basics – Single Hop localization

– Positioning in Multihop environment – Impact of anchor placement-

Topology Control – In Flat networks – In Hierarchical networks

UNIT IV 9

Routing protocols-Gossiping and agent-based unicast forwarding-

Energy-efficient unicast-Broadcast and multicast-Geographic routing-

Mobile nodes-Data-centric routing-Data aggregation-Data-centric

storage

UNIT V 9

Advanced in-network processing-Security-Denial of Service attacks -

Application-specific support

224

REFERENCE BOOKS:

1. Holger Karl & Andreas Willig, " Protocols And Architectures for

Wireless Sensor Networks" , John Wiley, 2005.

2. Feng Zhao & Leonidas J. Guibas, “Wireless Sensor Networks

3. Kazem Sohraby, Daniel Minoli, & Taieb Znati, “Wireless Sensor

Networks-Technology, Protocols, And Applications”, John Wiley,

2007

4. Anna Hac, “Wireless Sensor Network Designs”, John Wiley, 2003

WEB REFERENCES:

1. www.cs.uni-paderborn.de/index.php?id=1119&L=1

2. www.cpe.ku.ac.th/~cpj/204525/slides/02-Node.ppt

3. www.sensors-and-networks.blogspot.com/2011/08/physical-layer-

for-wireless-sensor.html

4. www.isi.edu/div7/publication_files/Ye02a.pdf

5. www.cs.wustl.edu/~jain/cse574-06/yftp/time_sync/index.html

6. www.macrothink.org/journal/index.php/npa/article/viewFile/279/276

7. www.site.uottawa.ca/~ivan/rout-ruehrup.pdf

8. www.cs.wayne.edu/~weisong/papers/walters05-wsn-security-

survey.pdf

9. www.ece.iastate.edu/~kamal/Docs/kk04.pdf

10. ieeexplore.ieee.org/iel5/7384/32301/01507522.pdf

11. 2009.telfor.rs/files/radovi/03_12.pdf

12. www.isi.edu/scadds/papers/timesync.pdf

225

15MIA08 CONCURRENT PROGRAMMING L T P C

3 0 0 3

COURSE OBJECTIVES:

To learn about Concurrency and POSIX thread concepts

To understand the various types of Synchronization

To familiarize with Advanced Threaded Programming

To study the usage of POSIX With Threads

COURSE OUTCOMES:

Apply POSIX threads for concurrency

Demonstrate Synchronization for an Application

Utilize advanced Threading concepts for various applications

Implement POSIX with threads for different applications

Make use of the hints to avoid debugging

UNIT I INTRODUCTION AND THREADS 9

Definitions and terminology - Asynchronous - Concurrency - Uniprocessor

and multiprocessor – Parallelism - Thread safety and reentrancy -

Concurrency control functions - Asynchronous programming is intuitive -

Asynchronous programming - Benefits of threading - Costs of threading

POSIX thread concepts - Architectural overview - Types and interfaces -

Creating and using threads - The life of a thread – Creation - Startup -

Running and blocking - Termination – Recycling

UNIT II SYNCHRONIZATION 9

Synchronization - Invariants, critical sections, and predicates – Mutexes -

Creating and destroying a mutex - Locking and unlocking a mutex -

Nonblocking mutex locks - Using mutexes for atomicity - Sizing a mutex

to fit the job - Using more than one mutex - Lock hierarchy - Lock

chaining- Condition variables - Creating and destroying a condition

variable - Waiting on a condition variable - Waking condition variable

waiters - One final alarm program - Memory visibility between threads - A

226

few ways to use threads Pipeline - Work Crew - Client/Server

UNIT III ADVANCED THREADED PROGRAMMING 9

One-time initialization - Attributes objects - Mutex attributes - Condition

variable attributes - Thread attributes - Cancellation - Deferred

cancelability - Asynchronous cancelability - Thread-specific data - Real

time scheduling - Threads and kernel entities.

UNIT IV POSIX WITH THREADS 9

Fork - exec - Process exit – Stdio - Thread-safe functions - User and

terminal identification - Directory searching - String token - Time

representation - Random number generation - Group and user database

– Signals - Signal actions - Signal masks - pthread_kill - sigwait and

sigwaitinfo - SIGEV_THREAD - Semaphores: synchronizing with a

signal-catching function

UNIT V ERROR HANDLING TECHNIQUES 9

Hints to avoid debugging: Avoiding incorrect code - Avoid relying on

“thread inertia” - Never bet your mortgage on a thread race - Cooperate

to avoid deadlocks - Beware of priority - Never share condition variables

between predicates - Sharing stacks and related memory - Avoiding

performance problems - concurrent serialization - right number of

mutexes - Never fight over cache lines

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. David R. Butenhof, “Programming with POSIX Threads”, Addision

Wesley, 1997.

2. Dick Buttlar, Jacqueline Farrell, Bradford Nichols, “PThreads

Programming” , O'Reilly, 1996.

3. M. Herlihy and N. Shavit, “The Art of Multiprocessor

Programming”, Morgan Kaufmann, 2012.

4. Michel Raynal, “Concurrent Programming: Algorithms, Principles,

and Foundations”, Springer, 2003.

227

WEB REFERENCES:

1. http://docs.oracle.com/javase/tutorial/essential/concurrency/

2. http://gee.cs.oswego.edu/dl/cpj/

15MIA09 VIDEO PROCESSING USING OPENCV L T P C

3 0 0 3

COURSE OBJECTIVES:

To study the image processing fundamentals

To understand the basics of video processing and video coding.

To study the general methodologies of motion estimation

To get introduced to OpenCV

To learn to apply video processing in OpenCV

COURSE OUTCOMES:

Work with Images on simple operations

Apply video processing to solve real world problems

Analyze various methodologies for motion estimation

Apply OpenCV functions for image processing

Implement video processing functions using OpenCV

UNIT I FUNDAMENTALS OF IMAGE PROCESSING 9

Introduction – Elements of visual perception – Steps in image processing

systems – Digital imaging system – Image acquisition – Sampling and

quantization – Pixel relationships – File formats – Color images and

models – Image operations – arithmetic, logical, statistical and spatial

operations.

228

UNIT II VIDEO PROCESSING 9

Introduction – Basic steps of video processing - Analog video, Digital video

– Time – varying – Image formation models: Three-Dimensional motion

models – Geometric image formation – Photometric image formation –

Sampling of video signals – Filtering operations.

UNIT III MOTION ESTIMATION 9

2-D motion estimation optical flow – General methodologies – Pixel based

motion estimation – Block – Matching algorithm – Mesh based motion

estimation – Global motion estimation – Region based motion estimation –

Multi resolution motion estimation – Waveform based coding – Block

based transform coding – Predictive coding – Application of motion

estimation in video coding.

UNIT IV OPENCV 9

Introduction to OpenCV – OpenCV primitive data types – CVMat matrix

structure – Ipl image data structure – Matrix and image operators –

OpenCV functions for displaying images – OpenCV functions for image

processing – OpenCV functions for image transforms.

UNIT V HANDLING IMAGE AND VIDEO FILES 9

Introduction – Downloading and installing OpenCV – Structure of OpenCV

– Creating user projects with OpenCV – Reading and writing image files –

Real-Time Computer Vision with OpenCV – Image processing for video –

Video stabilization – Super resolution – Stitching – Tracking and Motion –

The Basics of Tracking – Corner Finding – Mean-Shift and Camshift

Tracking – Motion Templates – User interaction tools

TOTAL: 45 Periods

REFERENCE BOOKS:

1. R. C. Gonzalez, R. E. Woods, “Digital Image Processing”, Pearson

Education. Third Edition, 2014.

2. Yao wang, Joem Ostarmann and Yaquin Zhang, ”Video processing

and communication “,1st edition , PHI

229

3. Gary Bradski and Adrian Kaehler, “Learning OpenCV” ORIELLEY,

2003.

4. Gloria Bueno García, Oscar Deniz Suarez, Jose Luis Espinosa

Aranda, Jesus Salido Tercero, Ismael Serrano Gracia, Noelia Vállez

Enano,”Learning Image Processing with OpenCV”, Packt Publishing,

2015

5. A.K.Jain, “Fundamentals of Digital Image Processing”, Prentice-Hall,

1989.

6. A.Bovik, “Handbook of Image and Video Processing”, 2nd Edition,

Academic Press, 2005.

7. A. M. Tekalp, Digital Video Processing , Prentice-Hall, 1995

8. Kari Pulli, Anatoly Baksheev, Kirill Kornyakov, and Victor Eruhimov,

“Real-Time Computer Vision with OpenCV”, communications of the

ACM, no. 6, vol. 55, June 2012.

WEB REFERENCES

1. http://opencv-python-

tutroals.readthedocs.org/en/latest/py_tutorials/py_gui/py_table_of_co

ntents_gui/py_table_of_contents_gui.html

2. http://opencv.org/

3. http://docs.opencv.org/opencv_tutorials.pdf

15MIA10 RURAL TECHNOLOGY AND COMMUNITY

DEVELOPMENT

L T PC

3 0 0 3

COURSE OBJECTIVES:

To understand the Importance, scope and objectives of Rural

Development

To describe the importance of Rural Delivery System

To provide an introduction , overview as well as its underlying

Premises

To understand the variety of ways in which communities organize,

230

assess and plan for community development

To discuss the need for communities to effectively integrate skill

development into their activities

To provide a broad perspective on the total community

assessment process.

To discuss comprehensive assessments and the areas that should

be considered, including a community’s physical, social and

human infrastructure and capital.

To provide information on techniques such as asset inventories,

identifying potential partners and collaborators

To provides an overview of economic impact analysis and how it

may be used to allocate scarce community financial resources

To discuss the issues impacting community development, focuses

on a few of the many and diverse issues

COURSE OUTCOMES:

Examine the objective of Rural Development scheme

Attain the knowledge in Rural Delivery System

Learn the introduction, overview of the discipline as well as its

underlying Premises

Identify the ways in which communities organize, assess and plan

for community development

Analyze the issues impacting community development, focuses

on a few of the many and diverse issues

UNIT I RURAL DEVELOPMENT 9

Importance, scope and objectives of rural Development; Various

approaches to Rural Development – Gandhian approach for Community

development- I.A.D.P.- I.R.D.P.- N.R.E.G.A.- Neo Gandhian- (PURA)-

Need Based and demand based centers.

231

UNIT II RURAL DELIVERY SYSTEM 9

Rural Development Administration and Panchayat Raj Institutions:

Panchayat Raj System- functions of Panchayat Raj System- Sources of

income for Panchayats- merits and demerits of Panchayat system-

strengthening of Panchayat Raj System- Rural Development

administration - People’s Participation in Rural Development: Importance

of people’s participation- some problems- and measures of strengthen

people’s participation.

UNIT III COMMUNITY DEVELOPMENT FOUNDATIONS 9

A framework for community and economic development- Seven

theories for seven community developers- Asset based community

development- Social Capital and community building- community

development practice.

UNIT IV PREPARATION AND PLANNING 9

Community visioning and strategic planning- Establishing community -

based organizations- Developing community leadership skills-

community development assessments- community assets mapping and

surveys- Assessing your local economy.

UNIT V ISSUES IMPACTING COMMUNITY DEVELOPMENT 9

Community development finance- Securing grants for community

development projects- The global economy and community

development- Sustainability in community development- Conclusions

and observations on the future of community development

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Dr.Sundaram, I.SATYA, “Rural Development” ,Himalaya

Publishing House, Mumbai, 1999

2. Rhonda Phillips and Robert H. Pittman “An introduction to

Community

232

development”, Routledge 2009

3. Desai, Vasant. “Rural Development in India”, New Delhi: Himalaya,

2005.

4. Battacharya S.N. (1972),” Community Development in Developing

Countries”, Academic Publishers.

5. M.J.Campbell “New Technology And Rural Development”,

Routledge 2009

6. Joseph, M.K. ; Andrew, T.N.” Participatory approaches for

the development and use of Information and

Communication Technologies (ICTS) for rural farmers” Technology

and Society, 2008. ISTAS 2008

7. Meera K. Joseph Theo. N. Andrew” Information and

Communication Technology policy imperatives for rural women

empowerment: focus on South Africa”AFRICON, 2009. AFRICON

'09.

15MIA11 PEDAGOGY L T P C

3 0 0 3

COURSE OBJECTIVES:

Instill pedagogical skill sets through an introduction to theoretically-

based teaching methods and strategies that can be incorporated into

your future teaching or collaborative opportunities.

Identify the ways that the personal research can be transferred to

other educational contexts

Explore the impacts of teaching and curricular innovations on

“student” to the learn the activities of K-12, collegiate, working

professional and research group member

COURSE OUTCOMES:

Analyze the differences between expert and novice learners

Apply the key factors that influence knowledge transfer

http://ieeexplore.ieee.org/search/searchresult.jsp?searchWithin=p_Authors:.QT.Joseph,%20M.K..QT.&searchWithin=p_Author_Ids:37669849900&newsearch=true

http://ieeexplore.ieee.org/search/searchresult.jsp?searchWithin=p_Authors:.QT.Andrew,%20T.N..QT.&searchWithin=p_Author_Ids:37666278600&newsearch=true

http://ieeexplore.ieee.org/xpl/articleDetails.jsp?tp=&arnumber=4559774&queryText%3Drural+technology+and+community+development



http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=4558058




233

Explore the mind and brain of people to leverage the awareness on

the educational contexts

Discover the four dimensions of the “How People Learn” (HPL)

framework to improve the learning efficiency of the society.

Operationalize HPL elements in STEM learning environments.

Identify the challenges of HPL elements using STEM learning

environments.

Evaluate the importance of assessment in engineering education

Apply Thematic Curriculum and Project-Based Learning best

practices to lesson planning

Plan a STEM curriculum that brings together the above lessons and

best practices

UNIT I TEACHING ENGINEERING 9

Introduction – Components of Good Teaching – Philosophical Approach –

Compendium of Learning Principles – Efficiency – Goal Setting –

Priorities and To-Do List – Interaction with People – Using a Computer –

Research Efficiency – Handling Stress – Limitation

UNIT II DESIGNING THE CLASS ROOM 9

Types of Courses – Classroom Activities – New Faculty Member

Experiences – Goals and Objectives - Taxonomies or Domains of

Knowledge – Affective Domain - Psychomotor Domain - Interaction of

Teaching Styles and Objectives - Developing the Content of the Course -

Accreditation Constraints on Undergraduate Programs

UNIT III PROBLEM SOLVING AND CREATIVITY 9

Problem Solving—An Overview - Novice And Expert Problem Solvers -

Problem-Solving Strategies - Getting Started Or Getting Unstuck -

Teaching Problem Solving – Creativity – Lectures - Content Selection and

Organization – Performance - Building Interpersonal Rapport in Lectures -

234

Special Lecture Methods - Handling Large Classes - Lectures As Part of A

Course Introduction

UNIT IV TECHNOLOGICAL ALTERNATIVES TO LECTURE 9

Cooperative Group Learning - Group Methods for Involving Students -

Mastery and Self-Paced Instruction - Independent Study Classes:

Increasing Curriculum Flexibility - Field Trips and Visits - Teaching with

Technology - Computers in Engineering Education – Audio tutorial

Method

UNIT V ONE-TO-ONE TEACHING AND ADVISING 9

Tutoring and Helping Students - Advising and Counseling - Research

Advisers - Testing, Homework and Grading – Scoring– Homework –

Projects – Grading - Student Cheating, Discipline and Ethics - Other

Discipline Problems - Teaching Ethics - Psychological Type and Learning

- Applications of the MBTI in Engineering Education - Difficulties with

Psychological Testing

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Phillip C Wankat, Frank S Oreovicz, “Teaching Engineering,” McGraw-

Hill, 1993

2. Julie Dirksen, “Design For How People Learn (Voices That Matter),”

New Riders (A Division of Pearson Education), Berkeley, CA, 2012.

3. Wiggins G, McTighe, “Understanding by Design,” Upper Saddle, NJ:

Prentice Hall, 1998.

4. John D.Bransford, Ann L.Brown, and Rodney R.Cocking, “How People

Learn Brain, Mind, Experience, and School,” National Academy Press

Washington, D.C., 2000 (Expanded Edition).

5. Select Committee on Science and Technology, “Higher Education in

Science, Technology, Engineering and Mathematics (STEM) subjects,”

House of Lord, UK, 2012-13.

235

WEB REFERENCES:

1. Golde CM, “The Challenges Of Conducting Interdisciplinary Research In

Traditional Doctoral Programs,” Ecosystems 1999; 2(4): 281-285.

2. Stephens R, Richey M, “Accelerating STEM Capacity : A Complex

Adaptive System Perspective. Journal Of Engineering Education,

100(3), 417-423.

3. Newstetter, W. C. (2011). UNPACKING THE INTERDISCIPLINARY

MIND: Implications For Teaching And Learning. American Society For

Engineering Education (Pp. AC 2011-2614).

15MIA12 IT ESSENTIALS L T P C

3 0 0 3

COURSE OBJECTIVES:

To be familiar with the basic concepts of computer architecture and

operating systems

To understand various methods of problem solving

To acquire knowledge on database and query language

To familiarize object oriented concepts

To provide a background on networking and web development

COURSE OUTCOMES:

Explore the concepts of computer architecture and operating systems

Develop solutions using problem solving concepts

Build data models for databases using query languages

Implement object oriented concepts for applications

Develop knowledge on networking and web applications

236

UNIT I 9

Fundamentals of Computer architecture-introduction-organization of a

small computer - Central Processing Unit - Execution cycle – Instruction

categories – measure of CPU performance Memory – Input/output devices

- BUS-addressing modes - System Software – Assemblers – Loaders and

linkers – Compilers and interpreters - Operating system – introduction –

memory management schemes Process management Scheduling –

threads.

UNIT II 9

Problem solving with algorithms- Programming styles – Coding Standards

and Best practices - Introduction to C Programming - Testing and

Debugging. Code reviews - System Development Methodologies –

Software development Models - User interface Design – introduction – The

process – Elements of UI design & reports.

UNIT III 9

RDBMS- data processing – the database technology – data models - ER

modeling concept –notations – Extended ER features - Logical database

design - normalization - SQL – DDL statements – DML statements – DCL

statements - Writing Simple queries – SQL Tuning techniques –

Embedded SQL - OLTP

UNIT IV 9

Objected oriented concepts – object oriented programming - UML Class

Diagrams– relationship – Inheritance – Abstract classes – polymorphism -

Object Oriented Design methodology - Common Base class - Alice Tool –

Application of OOC using Alice tool.

UNIT V 9

Client server computing - Internetworking – Computer Networks – Working

with TCP/IP – IP address – Sub netting – DNS – VPN – proxy servers -

World Wide Web – Components of web application - browsers and Web

Servers - URL – HTML – HTTP protocol – Web Applications - Application

servers – Web Security.

TOTAL: 45 PERIODS

237

REFERENCE BOOKS:

1. Andrew S. Tanenbaum, Structured Computer Organization, PHI, 3rd

ed., 1991

2. Silberschatz and Galvin, Operating System Concepts, 4th ed.,

Addision-Wesley, 1995

3. Dromey R.G., How to solve it by Computers, PHI, 1994

4. Kernighan, Ritchie, ANSI C language PHI,1992

5. Wilbert O. Galitz, Essential Guide to User Interface Design, John

Wiley, 1997

6. Alex Berson, Client server Architecture, Mc Grew Hill International,

1994

7. Rojer Pressman, Software Engineering-A Practitioners approach,

McGraw Hill, 5th ed., 2001

8. Alfred V Aho, John E Hopcroft, Jeffrey D Ullman, Design and

Analysis of Computer Algorithms, Addison Wesley Publishing Co.,

1998

9. Henry F Korth, Abraham Silberschatz, Database System Concept, 2nd

ed. McGraw-Hill International editions, 1991

10. Brad J Cox, Andrew J.Novobilski, Object – Oriented Programming –

An evolutionary approach, Addison – Wesley, 1991

238

ALLIED ELECTIVES OFFERED BY MBA DEPARTMENT

SL.

NO.

COURSE


1. 15BAA01 Essentials of Finance 3 0 0 3

2. 15BAA02 Essentials of Marketing 3 0 0 3

3. 15BAA03 Essentials of Human Resources

Management

3 0 0 3

15BAA01 ESSENTIALS OF FINANCE

(Allied Elective)

L T P C

3 0 0 3

COURSE OBJECTIVES:

To develop an understanding of business related finance.

To have an understanding of finance in order to contribute to the

organization’s success.

To improve the financial skills in order to make critical business

decisions involving budgets, cost savings and growth strategies.

COURSE OUTCOMES:

Upon completion of this course the student will be able to:

understand financial terms

interpret financial statements

make decision on budgeting and investment

communicate with financial experts

UNIT I Introduction to Finance 9

Role for Finance for Individual and Organization – Goals and Functions of

239

Finance - Time Value of Money – Significance

UNIT II Financial Planning and Decisions 9

Financial Planning – Decisions – Investment Decision – Financing

Decision - Dividend Decision - Evaluation of Investment Projects and

Financing – Working Capital

UNIT III Funds Management 9

Funds Mobilization – Sources – Internal and external

UNIT IV Financial Statements 9

Financial Statements - Balance Sheet – PL account - Cash/Fund Flow -

Analysis

UNIT V Overview of Indian Financial Markets 9

Financial System – Bank and Financial Institutions – Capital Market -

Money Market

TOTAL: 45 PERIODS

TEXTBOOKS:

1. I. M. Pandey, “Financial Management”, (10th ed.), Vikas Publishing

House Pvt. Ltd., 2013.

REFERENCE BOOKS:

1. Prasanna Chandra, “Financial Management”, (7th ed.), Tata

McGraw Hill, 2008.

2. Khan M Y and Jain P K, “Financial Management”, (6th ed.), McGraw

Hill, 2013.

240

15BAA02 ESSENTIALS OF MARKETING

(Allied Elective)

L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the basics of Marketing Management as a

functional area of an organisation.

To understand the basic elements that makes up the marketing

function.

To understanding the functions of a marketing department.

To understand the importance of marketing to an organisation.

COURSE OUTCOMES:

At the end of this course students will be able to:

Describe a Marketing Department and the functions of a marketing

department.

Choose and understand the needs of the customers.

Combine the four Ps of marketing to design a marketing model

Have a basic ideas on how a market segmented and customers

are targeted.

Have a basic understanding on the elements of the marketing mix

UNIT I Understanding Marketing Management –

an overview

9

Introduction, Marketing department functions, Selling vs Marketing,

Marketing concepts (Marketers and Prospects, Needs, Wants, and

Demands, Value and Satisfaction), Basics of Market segmentation,

Target markets and Positioning.

UNIT II The Marketing mix element – Product 9

Introduction, Characteristics of the product life cycle and their marketing

implications, Facets of the PLC, New product development, The market

diffusion process, Organizing for new product development

241

UNIT III The Marketing mix element – Price 9

Introduction, Price and the marketing mix, Pricing objectives, Factors

affecting pricing decisions, Setting a price, Pricing industrial goods,

Pricing and information technology

UNIT IV The Marketing mix element – Promotion 9

Communications contact techniques (Promotion mix) - Advertising, Direct

marketing, Sales promotion, Personal selling, Sponsorship, Publicity

UNIT V The Marketing mix element – Place:

channels of distribution

9

Introduction, Intermediaries in channels of distribution - Sales agents,

Distributors, Wholesalers, Retailers, Franchising, Internet marketing.

TOTAL: 45 PERIODS

TEXTBOOKS:

1. Marilyn A. Stone, John Desmond, “Fundamentals of Marketing”

(Special Indian Edition), Routledge, Taylor & Francis Group, 2014.

REFERENCE BOOKS:

1. William J. Stanton, Michael J. Etzel, Bruce J. Walter,

“Fundamentals of Marketing”, (10th ed.), TMH, 1994.

2. Philip Kotler, “Marketing Management: A South Asian Perspective”,

(14th ed.), Pearson India, 2012.

15BAA03 ESSENTIALS OF HUMAN RESOURCE

MANAGEMENT (Allied Elective)

L T P C

3 0 0 3

COURSE OBJECTIVES:

To make the participant understand the role of HR Department in an

organization

To know the various functional areas of HRM

242

To understand the recent developments in HR

COURSE OUTCOMES:

Students will understand the basic concepts in HRM

Students will be aware of human resource requirement for an

organization

Students will be aware of the ways for developing the skills and

knowledge of the employees

Students will be able to understand the motivation model in an

organization

Students will be aware of present development in HR

UNIT I Introduction 9

Introduction to HRM – Meaning, Importance and Objectives, History of

Managing Human Resources, Environment of HR. Functions and Roles of

HR Manager

UNIT II Procurement of Human Resources 9

Job Analysis – Meaning, Process and Methods, Human Resource Planning

– Importance, Process, HR Demand and Supply Forecasting Techniques.

Recruitment – Importance, Recruitment Sources, Selection – Process

Socialization / Induction – Importance and Types

UNIT III Development / Training 9

Training – Purpose, Process – Need Identification, On-the-Job Methods

and Off-the-Job Methods. Executive Development Programmes –

Difference from training. Performance Appraisal – Process, Techniques –

MBO and 360 Degree Feedback. Job Changes - Promotion, Demotion and

Transfer

UNIT IV Compensation and Motivation 9

Job Evaluation – Meaning, Process, Compensation Plan – Deciding factors

& Framing Process. Human Needs – Motivation Theories – Maslow’s Need

theory and Herzberg’s two factor theory, Applications – Rewards and

243

Reinforcement. Grievances – Causes and Redressal methods. Disciplinary

Action – Nature and Types

UNIT V Maintenance and Separation 9

The Factories Act, 1948 – Health, Safety and Welfare Provisions. The

Industrial Employment (Standing Orders) Act, 1946 – Framing Standing

Order. Separation – Retirement, Layoff, Out-placement & Discharge. Latest

trends in HRM - HRIS – Meaning and Implementation Process. E-HRM.

TOTAL: 45 PERIODS

TEXTBOOKS:

1. Arun Monappa, “Managing Human Resources”, (1st ed.), Trinity Press

Publications, 2014.

2. Dessler, “Human Resource Management”, (12th ed.), Pearson

Education Limited, 2011.

REFERENCE BOOKS:

1. Aswathappa K., “Human Resource Management”, (7th ed.), 2013,

Tata McGraw Hill, New Delhi.

2. Decenzo and Robbins, “Human Resource Management”, (10th ed.),

Wiley, 2010.

3. Mamoria C.B & Mamoria S., “Personnel Management”, Himalaya

Publishing Co., 2010.

4. Eugence Mckenna & Nic Beach, “Human Resource Mgmt”, (2nd ed.),

Pearson Education Ltd, 2008.

5. Wayne Cascio, “Managing Human Resource”, (9th ed.), Tata McGraw

Hill, 2012.

6. Ivancevich, “Human Resource Management”, (12th ed.), Tata

McGraw Hill, New Delhi, 2012.

244

ALLIED ELECTIVES OFFERED BY MCA DEPARTMENT

SL.

NO.

COURSE


SEMESTER IV

1 15CAA01 Office Automation 3 0 0 3

2 15CAA02 Fundamentals of Programming 3 0 0 3

3 15CAA03 Fundamentals of Database Design

3 0 0 3

4 15CAA04 Software Design 3 0 0 3

5 15CAA05 Software Documentation 3 0 0 3

6 15CAA06 Desk Top Publishing 3 0 0 3

7 15CAA07 Web Programming 3 0 0 3

8 15CAA08 Object Oriented programming 3 0 0 3

9 15CAA09 Mobile Programming 3 0 0 3

10 15CAA10 Graphics Programming 3 0 0 3

15CAA01

OFFICE AUTOMATION L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand basic computer operations and the principal

components of a computer and connected peripheral devices

To understand and examine current operating systems, software

utilities and application software

245

To become proficient in using the following:

- Windows

- Word Processing Applications

- Spreadsheet Applications

- Database Applications

- Presentation Graphics Applications

To understand the basics of e-mail and newsgroups

To introduce networking concepts including the Internet and its

components and web browser basics.

COURSE OUTCOMES:

Demonstrate an understanding of computer hardware and software

Describe the features and functions of the categories of application

software

Present conclusions effectively, orally and in writing

Understand the dynamics of an office environment

Demonstrate the ability to apply application software in an office

environment

UNIT I FUNDAMENTALS OF COMPUTER 9

Introduction - Data & Information - History of Computer – Characteristics -

Generations of Computer - Computer Organization – Hardware - Software

– Concepts, Types of Software - Memory – Types - Number System

Conversion - Algorithms and Flowcharts.

UNIT II OPERATING SYSTEM 9

Introduction - MS-Dos – History, Files and Directories, Internal and External

Commands, Batch Files, MS-Windows - Features of MS – Windows,

Control Panel, Taskbar, Desktop, Windows Application, Icons, Windows

Accessories, Notepad, Paintbrush.

UNIT III WORD PROCESSORS AND

SPREADSHEETS

9

246

Office package – Introduction – MS Office – MS Word – Screen layout –

Menus – Formatting Documents – Text handling – Editing a text – viewing

text – Header and footer – Inserting page numbers, pictures, web links –

Formatting the text – Table Handling – word tools – spell check and

grammar, letters and Mailing.

MS Excel – Introduction – parts of MS Excel Window – Workbook –

Entering data - Editing data – Viewing data – Formatting data – Handling

formulae in Excel – Functions – Date arithmetic – Handling data – Viewing

Data – Headers and Footers – Working with charts – Formatting charts –

Excel tools for checking spelling.

UNIT IV PRESENTATION AND DATABASE

PACKAGES

9

MS PowerPoint – parts of PowerPoint window – creating a presentation –

insert slides – Formatting presentations – Editing presentations – View

Slide – Slide Sorter – Slide Show –Header and Footer– Animation

Schemes – tools – spelling and grammar.

MS Access - Introduction, Planning a Database - Creating Database -

Creating Tables - Working with Forms - Creating queries - Finding

Information in Databases - Creating Reports - Types of Reports – Importing

data from other databases.

UNIT V INTERNET AND APPLICATIONS 9

Introduction -History and concept of Internet, technological foundation of

Internet, Domain name systems (DNS) and IP addresses, Internet

protocols - Applications – Email – uses – Working with mails - File

attachment.

TOTAL: 45 HOURS

TEXT BOOK:

1. Vikas Gupta, “Comdex Computer Course Kit (XP Edition)”, Dreamtech,

New Delhi, 2003.

247

REFERENCE BOOKS:

1. Ashok N. Kamthane, “Computer programming”, Pearson Education,

2007.

2. D.P.Curtin, K.Foley, K. Sen and C.Mortin, “Information Technology –

the Breaking Wave” Irwin/Mcgraw-Hill, 3rd Edition, 1999.

3. Stacey C. Sawyer, Brian K. Williams, Sarah Hutchinson Clifford,

“Using Information Technology: Brief”, McGraw Hill International

Edition, 1999.

15CAA02

FUNDAMENTALS OF PROGRAMMING L T P C

3 0 0 3

COURSE OBJECTIVES:

To learn how to write modular and readable C program.

To exploit the basic concept of Programming.

To represent any problem by good algorithms.

To study fundamental programming concepts like control structure

and looping.

To learn the advanced concepts like pointers, structures

To be able to analyze the complexity of algorithms

COURSE OUTCOMES:

Develop modular C programs for the given problem.

Understanding the Fundamentals and logics of C programming.

System programming like memory management using pointers.

Analyzing the time and space complexity

UNIT I Program Planning Concepts 9

Algorithm – Definition – Different ways of representing an algorithm – As

a Flow chart – As a Pseudo code – As a program – Types of

248

programming languages – Machine level, Assembly level, High level

languages – Tools – Compiler, Linker, Interpreter – Debugging – Syntax

errors, logic errors

UNIT II Introduction to C 9

Introduction to C Programming – Operators and Expressions – Data

Input and Output– Program Structure – Stages of Compilation of a

Program.

UNIT III Functions and Arrays 9

Control Statements – Introduction to Pointers - Functions – Defining a

Function – Accessing a Function – Function Prototypes – Passing

Arguments to a Function – Recursion – Storage classes - Arrays –

Defining and Processing Arrays – Passing arrays to a Function –

Multidimensional Arrays – String and array of strings - String processing

– Library functions.

UNIT IV Pointers and Structures 9

Pointer Declaration – Dynamic Memory Allocation – Arrays of Pointers –

Double pointers - Representing arrays using pointers – Pass by value

and Pass by reference – Strings representation using pointers - Defining

a Structure – Processing a Structure – Passing Structures to Functions -

Structure and arrays – Unions

UNIT V Analysis of Algorithms 9

Fundamentals of the analysis of algorithm efficiency – analysis frame

work – Analysis of Algorithm: Measuring an Input’s size, Measuring

Running Time, Orders of Growth, Worst Case, Best Case and Average

Case Efficiencies, Asymptotic Notations - Mathematical analysis for

recursive and non-recursive algorithms – NP problems

TOTAL: 45 HOURS

249

Text Book:

1. Byron S Gottfried,”Programming with C”, Schaum’s Outlines, Tata

McGraw Hill, Second Edition, 2006.

2. Anany Levitin, "Introduction to the Design and Analysis of

Algorithms", Pearson Education, 2003.

REFERENCE BOOKS:

1. E. Balagurusamy, “Programming in ANSI C”, Tata McGraw-Hill

Education, 5th edition, 2010.

2. Deitel and Deitel, “C How to program”, Prentice Hall.

3. B.W. Kerninghan, D.M. Ritchie, “The C Programming Language”,

2nd Edition, 1995, PHI.

4. Pradip Dey, Manas Ghose, “Fundamentals of computing and

Programming in C”.

5. Ashok N. Kamthane, “ Computer Programming”, Pearson Education.

6. Mark Allen Weiss, “Data Structures and Algorithm Analysis in C”,

Second Edition, Pearson Education, 2006.

15CAA03

FUNDAMENTALS OF DATABASE DESIGN L T P C

3 0 0 3

COURSE OBJECTIVES:

Understand the role of a database management system in an

organization.

Construct simple and moderately advanced database queries using

Structured Query Language (SQL).

Understand the basic commands in DbaseIIIPlus, Foxpro, MS-

Access and Oracle

Design and implement a small database project using Microsoft

Access.

Understand the role of the database administrator.

http://www.google.co.in/search?tbo=p&tbm=bks&q=inauthor:

250

COURSE OUTCOMES:

Understand database concepts and structures.

Explain terms related to database design and management.

Understand the objectives of data and information management.

Use database management systems such as Microsoft Access and

Oracle SQL Plus.

Become proficient in using database query language, i.e., SQL.

UNIT I Introduction to File and DBMS 9

File - file organization of file - file storage organization - Why a database

- Characteristics of data in a database – DBMS - Why DBMS - type of

DBMS.

UNIT II DBaseIIIPlus 9

Language overview, Creating and modifying tables, Records, and fields,

Data types, Operators and expressions-Tables and indexes, Locating

data-Control structures, Program flow, Expressions and Operators

UNIT III Foxpro 9

Working with Foxpro creating database file some common operations on

data – create, list, append, close, quit-data types, viewing and editing

data , displaying and monitoring commands DISPLAY, LIST, LOCATE,

EDIT, CHANGE, BROWSE- SORING AND INDIEXING – FIND-SEEK

commands

UNIT IV MS-ACCESS 9

Creating a Database from a Template - Creating a Database and a Table

Manually-Creating a Table from a Template-Manipulating Table Columns

and Rows- Explore the user interface-Open, explore, and close a

database -Explore tables-Explore queries-Explore forms.-Preview a

report-Preview a table and a form

UNIT V ORALCE 9

SQL - SQL*Plus -Command Line Interface -Viewing a Sample Table -

251

Data Definition Language - Data Manipulation Language - Transaction

Control -Mathematical Functions - String Functions - Date Functions -

Conversion Functions

TOTAL: 45 HOURS

REFERENCE BOOKS:

1. Alex leon, Mathews Leon, ”Database Management Systems”, Leon

Vikas, 1999.

2. Taxali R.K., DBase III Plus made simple with dBase IV and

Foxbase+, Tata McGraw-Hill Publishing, 1991.

3. Taxali, “Foxpro 2.5 Made Simple”, BPB Publications, 1996.

4. Lambert & Cox, “Microsoft Access 2010: Step by Step”, Microsoft

Press, 2010.

5. Ivan Bayross, “SQL, PL/SQL the Programming Language of Oracle”,

2003.

15CAA04

SOFTWARE DESIGN L T P C

3 0 0 3

COURSE OBJECTIVES:

This course aims to introduce students to the basic principles of Systems

analysis and Design, to give them experience of developing a software

system in a team. Specifically:

Introduce students to the traditional practices for specification,

design, implementation, testing and operation of information

systems.

Provide a framework for more detailed material on design, involve

the students into development of a project, which relates to project

development conditions found in industry.

COURSE OUTCOMES:

On successful completion of this course students should:

252

Understand the qualifications of systems analysts and project

managers to design better information systems.

Discuss the aims and objectives of information systems in the

context of a human activity system for better systems

development.

Understand analysis and design techniques and methods to meet

the special needs of current information systems.

Use variety of analysis and design methods to specify and propose

information systems.

Be able to produce and document the key deliverables of software

development life cycle.

Know the use of CASE tools.

Identify current industry standards for information systems

development.

UNIT I General Design Fundamentals 9

The nature of Design process – Objectives – Building Models –

Constructs, Design qualities – Assessing the design – Design

viewpoints for software – The object Model – Classes and Objects –

Complexity – Classification – Notation – Process – Pragmatics.

UNIT II Structured System Analysis and Design 9

Structured Design – Design Principles – Problem Partitioning and

Hierarchy – Abstraction, Modularity – Top-down and Bottom-up

Strategies – Transformation of a DFD to a Structure Chart – Transform

Analysis – Transaction Analysis – Coupling – Cohesion – Multiple

types of Cohesion in a module.

UNIT III Object Oriented Analysis and Design 9

Overview of Object Oriented Analysis – Shaler/Mellor – Coad/ Yourdon

– Rumbaugh – Booch – UML – Use case – Conceptual model –

253

Behaviour – Class Analysis Patterns – Overview – Diagrams –

Aggregation – UML – Diagrams – Collaboration – Sequence – Class –

Design patterns and Frameworks - Evaluation testing – Coding –

Maintenance – Metrics.

UNIT IV Software Design 9

The Architecture Concepts – Design Methods – Design Patterns –

Rationale for Methods – Design Processes and Strategies – Design by

Template – Designing with Patterns – Stepwise Refinement –

Incremental Design – Prototyping

UNIT V CASE STUDIES 9

Domain Name System – Email – World Wide Web (HTTP) – Simple

Network Management Protocol – File Transfer Protocol – Security –

Mutimedia applications.

TOTAL: 45 HOURS

REFERENCE BOOKS:

1. David Budgen, "Software Design", Pearson Education, Second

Edition, 2004.

2. R. S. Pressman, "Software Engineering", McGraw Hill Inc., Fifth

Edition, 2001.

3. Steve McConnell, "Code Complete", Word Power Publishers,

2001.

4. Ed Downs, Peter Clare, Jan Coe, "Structured System Analysis and

5. Design Methods Application and Context ", Prentice Hall, 1998.

6. A. G. Suteliffe, "Human Computer Interface Design", Macmillan,

Second Edition, 1995.

254

15CAA05

SOFTWARE DOCUMENTATION L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the need for software documentation

To know about documentation planning

To study about document testing and

To know about documentation layout and guidelines to be followed

COURSE OUTCOMES:

Understand the basic concepts, techniques and applications of

software documentation.

Learn how to prepare the documentation.

Understand various steps involved in document preparation.

Learn about various layouts for documentation


Need for Software Documentation - Understanding task orientation -

Analysing users - Writing user scenarios - User informational needs -

Document goals - User work motivations - User analysis checklist -

Constructing a task list - Categorization - Writing steps as actions - Task

analysis.

UNIT II DOCUMENTATION PLANNING 9

Planning and writing documents - Task list and Schedule - Guidelines -

Documentation process - Documentation plan - Document review form -

Review plan - Schedule - Checklist.

UNIT III DOCUMENTATION TESTING 9

Usability tests - Advantages of field testing - Editing and fine tuning -

Problems - Designing for task orientation - Page showing elements of

document design - Screen showing elements for online help design -

Solutions to the design problem for printed and online documentation.

255

UNIT IV DOCUMENTATION LAYOUTS 9

Laying out pages and screens - Elements of page and screen design -

Designing type - Effective writing style - Using graphical that support

decision making - Functions of graphics - Type and elements of

graphics.

UNIT V DOCUMENTATION GUIDELINES 9

Writing to guide - Procedures - Guidelines - Writing to support -

Reference - Structural - reference entry - Checklist - Designing index -

User oriented index - Case studies.

TOTAL: 45 HOURS

TEXT BOOK:

1. Thomas T. Barker , "Writing S/W Documentation - a Task Oriented

Approach", Allyn & Bacon Series of Technical Communication , 1998.

REFERENCE BOOK:

1. Dan Jones, Sam Dragga, “Technical Writing Style", Pearson Education, 1997.

15CAA06

DESK TOP PUBLISHING L T P C

3 0 0 3

COURSE OBJECTIVES:

To prepare students having skills to work in the field of content designs or desk top publishing

To learn about fundamentals of computer

To gain knowledge about Pagemaker

To understand the advance concept about pagemaker

To Study theoretically and practically about coreldraw

To gain knowledge about photoshop

COURSE OUTCOMES:

Identify desktop publishing terminology and concepts

Manipulate text and graphics to create a balanced and focused

256

layout Create fliers, brochures, and multiple page documents


Introduction to Computers – Windows XP: Hardware Requirements,

Windows Desktop, Mouse Actions, Windows Components, Managing

Files and Folders, Windows Explorer, Recycle Bin, Control Panel -

DTP Basics: Paper Quality, Colours, Fonts – Hardware Requirements

for DTP – Design Steps – General Design Considerations – Text

Organization – Design of Common Media Publications.

UNIT II PAGEMAKER- I 9

Introduction to PageMaker - Components of PageMaker Window –

Publication – Creating and Modifying Publication - Components of

Sample Document – Handling Text – Multiple Text Blocks - Story

Editor – Spell Check and Correcting Mistakes – Formatting Text -

Changing Font and Font Size - Making and Removing Boldface,

Italics, Underlines – Aligning the Text – Tracking, Kerning and Leading

– Style Sheets – Bullets and Numbering.

UNIT III PAGEMAKER –II 9

Master Pages – Placing Elements on Master Pages – Managing

Master Pages – Columns – Graphics and Objects – Tool Bar –

Creating Simple Graphics – Adding Text to the Graphic – Importing

Graphic – Resizing and Moving a Graphic – Adding Caption to the

Graphic – Cropping a Graphic – Grouping and Ungrouping – Links –

Links Manager – Managing a Publication – Page Setup – Table of

Contents – Managing Books – Printing a Publication.

UNIT IV CORELDRAW 9

Introduction to CorelDraw – CorelDraw Screen – Property Bar –

Drawing Basic Geometric Figures – and Polygon – Views – View

Manager – Toolbox – Managing CorelDraw Projects – Flow, Dimension

and Out Lines – Object Reshaping – Transformation Dockers – Adding

Effects to Objects – The Text Tool – Creating Book Cover – Text

257

Conversion – Formatting Text – The Text Editor – CorelDraw Images –

Importing Images – Resizing, Rotating and Skewing Images –

Cropping an Image – Image Conversion – Adding Special Effects –

Exporting and Publishing – Managing Colour – Page Layout and

Background.

UNIT V PHOTOSHOP 9

Introduction to Photoshop CS2 – Program Window – The Toolbox –

Screen Modes – Managing Files – Photoshop Images – Image Size

and Resolution – Editing Images – Colour Modes – File Formats –

Selection and Selection Tools – Grow and Similar Commands – Edition

Selections – Copying and Filling a Selection – Transforming Selections

– Painting Tools – Drawing Tools – Retouching Tools. Layers – Layers

Palette – Creating a New Layers – Hiding and Showing Layers –

Repositioning Layers – Flattening Images – Adjustment Layers – Layer

Effects – Masking Layers – Types in Photoshop – Type Tool – Type

Settings – Type Masking – Filters – Filter Menu – Filter Gallery –

Extract Filter – Liquify Filter – Vanishing Point Filter – Artistic Filters –

Blur Filters – Brush Stroke Filters – Distort Filters – Noise Filters –

Pixelate Filters – Lighting Effects – Difference Clouds – Sharpen,

Sketch and Stylize Filters – Printing and Customization.

TOTAL: 45 HOURS

TEXTBOOK:

1. Vikas Gupta, “Comdex DTP”, Dreamtech Press, New Delhi, 2009.

15CAA07

WEB PROGRAMMING L T P C

3 0 0 3

COURSE OBJECTIVES:

To learn the concepts of WWW.

To develop web pages using HTML & CSS.

258

To study about the features of Java Script for developing web

pages.

To know about the advanced concepts of Java Script.

To develop web pages with Database connectivity using PHP.

COURSE OUTCOMES:

Upon completion of the course the students will be able to

Understand the concepts of WWW.

Develop web pages using HTML and CSS

Develop code using Java Script

Develop web pages using Java Script.

Develop web pages using PHP with Database connectivity

UNIT I INTRODUCTION TO WWW 9

Internet Standards – Introduction to WWW – WWW Architecture –

SMTP – POP3 – File Transfer Protocol - Overview of HTTP, HTTP

request – response –– Generation of dynamic web pages.

UNIT II UI DESIGN 9

Markup Language (HTML): Introduction to HTML and HTML5 -

Formatting and Fonts –Commenting Code – Anchors – Backgrounds –

Images – Hyperlinks – Lists – Tables – Frames-HTMLForms.

Cascading Style Sheet (CSS): The need for CSS, Introduction to CSS

– Basic syntax and structure - Inline Styles – Embedding Style Sheets -

Linking External Style Sheets – Backgrounds – Manipulating text -

Margins and Padding - Positioning using CSS.

UNIT III INTRODUCTION TO JAVASCRIPT 9

Introduction - Core features - Data types and Variables - Operators,

Expressions, and Statements - Functions - Objects - Array, Date and

Math related Objects - Document Object Model - Event Handling -

Controlling Windows & Frames and Documents - Form handling and

validations.

259

UNIT IV ADVANCED JAVASCRIPT 9

Browser Management and Media Management – Classes –

Constructors – Object–Oriented Techniques in JavaScript – Object

constructor and Prototyping - Sub classes and Super classes – JSON -

jQuery and AJAX.

UNIT V PHP 9

Introduction - How web works - Setting up the environment (LAMP

server) - Programming basics - Print/echo - Variables and constants –

Strings and Arrays – Operators, Control structures and looping

structures – Functions – Reading Data in Web Pages - Embedding

PHP within HTML – Establishing connectivity with MySQL database.

TOTAL: 45 HOURS

REFERENCES:

1. Harvey & Paul Deitel & Associates, Harvey Deitel and Abbey Deitel,

“Internet and World Wide Web - How To Program”, Pearson

Education, Fifth Edition, 2011.

2. Achyut S Godbole and Atul Kahate, “Web Technologies”, Tata

McGraw Hill, Second Edition, 2012.

3. Thomas A Powell, Fritz Schneider, “JavaScript: The Complete

Reference”, Tata McGraw Hill, Third Edition, 2013.

4. David Flanagan, “JavaScript: The Definitive Guide”, O'Reilly Media, Sixth Edition, 2011

5. Steven Holzner, “The Complete Reference - PHP”, Tata McGraw

Hill, 2008

6. Mike Mcgrath, “PHP & MySQL in easy Steps”, Tata McGraw Hill,

2012. http://php.net/manual/

260

15CAA08

OBJECT ORIENTED PROGRAMMING L T P C

3 0 0 3

COURSE OBJECTIVES:

To learn the basic concepts of object-oriented programming

To familiarize with constructor, destructor, operator overloading

and virtual functions and templates.

To learn the OOP concepts such as inheritance, Run Time

polymorphism and exceptional handling

COURSE OUTCOMES:

Understand the OOPs concepts

Design the class with constructor and destructors.

Apply exception handling mechanism for handling exceptions

Apply inheritance to classes and perform run time polymorphism

by using virtual function

UNIT I INTRODUCTION TO OBJECT-ORIENTED

PROGRAMMING

9

Introduction to OOP concepts – Procedure versus Object Oriented

Programming – Data types – Control structures – Arrays and

Strings – User defined types – Functions and Pointers. Classes and

Objects: Defining C++ classes – Methods – Access specifiers

UNIT II OBJECT ORIENTED PROGRAMMING

CONCEPTS

9

Concepts: abstraction - encapsulation – inheritance – abstract

classes – polymorphism – information hiding - function and data

members – inline - default arguments – function overloading –

friend functions – const and volatile functions – static functions.

UNIT III CONSTRUCTORS AND OVERLOADING 9

Constructors – default constructor – Parameterized constructors –

copy constructor - explicit constructor – destructors – operator

261

overloading – restrictions – overloading through member function -

overloading unary – binary - assignment, array subscript, function

call operator - overloading through friend functions.

UNIT IV EXCEPTION HANDLING AND TEMPLATES 9

Exception handling – try-catch-throw paradigm – multiple catch –

catch all - exception specification – rethrowing terminate and

Unexpected functions – Uncaught exception – Function templates -

class templates.

UNIT V INHERITANCE AND RUNTIME

POLYMORPHISM

9

Inheritance – is-a and part of relationship – public, private, and

protected derivations – inheritance types – virtual base class –

composite objects - Runtime polymorphism – this pointer - virtual

functions – uses - pure virtual functions – RTTI – typeid –

dynamic casting – RTTI and templates – cross casting – down

casting

TOTAL: 45 HOURS

TEXT BOOKS:

1. Paul Deitel and Harvey Deitel, “C++ How to Program”, Prentice

Hall, 8th Edition, 2013.

2. Bhusan Trivedi, “Programming with ANSI C++”, Oxford University

Press, Second Edition, 2012.

REFERENCE BOOKS:

1. Ira Pohl, “Object-Oriented Programming Using C++”, Second

Edition, 1997

2. Bjarne Stroustrup, “The C++ Programming Language”, Pearson

Education, Third edition, 2012.

3. Horstmann “Computing Concepts with C++ Essentials”, John

Wiley, Third Edition, 2003.

4. Robert Lafore, “Object-Oriented Programming in C++”, SAMS

262

Publications, Fourth Edition, 2009.

15CAA09

MOBILE PROGRAMMING L T P C

3 0 0 0

COURSE OBJECTIVES:

Build your own Android apps

Explain the differences between Android and other mobile

development environments

Understand how Android applications work, their life cycle, manifest,

Intents, and using external resources

Design and develop useful Android applications with compelling user

interfaces by using, extending, and creating your own layouts and

Views and using Menus

Take advantage of Android's APIs for data storage, retrieval, user

preferences, files, databases, and content providers

Tap into location-based services, geocoder, compass sensors, and

create rich map-based applications

COURSE OUTCOMES:

Upon successful completion of this Subject, the student shall be able to:

Understand the basic technologies used by the Android platform.

Recognize the structure of an Android app project. Be able to use

the tools for Android app development.

Become familiar with creating graphical elements, handling different

screen resolutions, and how graphical elements in an Android app

are displayed.

Create graphical user interfaces along with functionality for Android

apps.

Create various graphical assets for Android apps and create

animations and transitions.

Learn how the Android platform uses Intents. Write code to deal with

263

Content Providers.

Gain experience in location-based apps, including GPS sensors, and

Maps API.

UNIT I Introduction to Android 9

Introduction to Android Architecture: Introduction, History, Features and

Android Architecture. Android Application Environment, SDK, Tools:

Application Environment and Tools, Android SDK. Programming paradigms

and Application Components - Part 1: Application Components, Activity,

Manifest File, Programming paradigms and Application Components -

Part 2: Intents, Content providers, Broadcast receivers, Services.

UNIT II User Interface Design 9

User Interface Design part 1: Views &View Groups, Views : Button, Text

Field, Radio Button, Toggle Button, Checkbox, Spinner, Image View, Image

switcher, Event Handling, Listeners, Layouts : Linear, Relative, List View,

Grid View, Table View, Web View, Adapters. User Interface Design Part 2:

Menus, Action Bars, Notifications : Status, Toasts and Dialogs.

UNIT III Resources, Assets, Localization 9

Resources, Assets, Localization: Resources and Assets, Creating

Resources, Managing application resources and assets, Resource-

Switching in Android. Localization, Localization Strategies, Testing

Localized Applications, Publishing Localized Applications.

UNIT IV Data Storage 9

Content Providers: Contents provider, Uri, CRUD access, Browser,

CallLog, Contacts, Media Store, and Setting. Data Access and Storage:

Shared Preferences, Storage External, Network Connection. SQLite -

SQLite Databases.

UNIT V Native Capabilities 9

Camera, Audio, Sensors and Bluetooth: Android Media API: Playing

audio/video, Media recording. Sensors - how sensors work, listening to

sensor readings. Bluetooth. Maps & Location: Android Communications:

264

GPS, Working with Location Manager, Working with Google Maps

extensions, Maps via intent and Map Activity, Location based Services.

Location Updates, location-based services (LBS),Location Providers,

Selecting a Location Provider, Finding Your Location, Map - Based

Activities, How to load maps, To finding map API key.

TOTAL HOURS 45

TEXT BOOK:

1. Reto Meier, “Professional Android 4 Development”, John Wiley and

Sons, 2012.

2. W. Frank Ableson, RobiSen, Chris King, C. Enrique Ortiz, “Android in

Action”, Third Edition, 2012.

REFERENCE BOOKS:

1. Wei-Meng Lee, “Android Application Development Cookbook”, John

Wiley and Sons, 2013.

2. Grant Allen,“Beginning Android 4”, Apress, 2011.

15CAA10

GRAPHICS PROGRAMMING L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the basic concepts of graphic devices

To know the basic output primitives of Graphics

To study the attributes of drawings

To apply various transformations

To understand the applications of viewing and clipping

COURSE OUTCOMES:

Upon completion of the course, the student will be able to

Familiar with the graphics environment

Recognize different types of output primitives in graphics system

265

applying attributes to pictures

Implement the basics transformations using C built-in functions

Understand the applications of viewing and clipping


Graphics Display devices – Raster - random devices – difference

between raster and randam - working principles of CRT - kinds of display

devices.

UNIT II BASIC PRIMITIVES 9

Output Primitives - Points - Line Drawing - Circle Drawing – curve

drawing - polygon drawing - Text Display.

UNIT III ATTRIBUTES 9

Introduction to colors – point and Line attributes- circle, Character

Attributes – Polygon painting

UNIT IV Transformations 9

Basic Transformations – Translation – Scaling – rotation - special

transformations - reflection and shearing – examples.

UNIT V Viewing 9

Defnitions: window – viewport - applications of clipping - interior and

exterior clipping - text clipping.

TOTAL: 45 HOURS

TEXT BOOKS:

1. Donald Hearn and M. Pauline Baker, “Computer Graphics in C Version”,

Second Edition, Pearson Education, 2007.

REFERENCES:

1. Zhigang Xiang, Roy A. Plastock, “Schaum’s Outline of Computer

Graphics, McGraw Hill Professional, 2000.

2. http://www.programmingsimplified.com/c/graphics.h

266

SPECIAL COURSES

15BTS01 INDUSTRIAL TRAINING IN BIOPROCESS

ENGINEERING

L T P C

1 0 0 1

Course Objectives:

To make the students to understand the production processes involved in

bioprocess industries

Course Outcomes:

Able to understand the industrial practices

UNIT I Introduction To Bioprocess Equipments 1

Bioreactors, Fermentors, media/buffer preparation vessel, clean-in-place/steam-

in-place, blending vessel, vibromixers, crystallizers, filtration units- depth,

tangential flow (TFF and sterile filtration, mobile vessel and precipitation

vessels)

UNIT II 1

Process and Instrumentation diagram (P&ID)

UNIT III 1

Bioreactors versus Fermentors – Design similarity and differences

UNIT IV 1

Design Principles – Reactor size, geometry (H/D Ratio), agitators (types of

agitators) baffles (headspace, bubble and micro spargers); Tip speed

calculation.

267

UNIT V 1

Heat transfer in bioprocess – Heat Balance with examples from anaerobic,

aerobic and mammalian cell culture - Types of heat exchanger in reactors-

Jacketed tank, helical coils, tube baffles

UNIT VI 1

Control Loops involved in Bioprocess equipments

Practicals

Tangential Flow Systems – Microfiltration & Ultra filtration 3

Fermentation Technology – Understanding of Lab Scale Fermentor 3

Fermentation Technology – Introduction to Pilot Scale Fermentor 3

TOTAL: 15 PERIODS

REFERENCE BOOKS:

1. Bailey, J.E. and Ollis, D.F., “Biochemical Engineering Fundamentals”,

McGraw Hill, 2nd Edition, 1986.


Facilities” Wiley-Blackwell, 1st Edition, 1994.

3. Blanch H.W., Clark D. S., “Biochemical Engineering”, Marcel Dekker, Inc.

2nd Edition, 1997.

15BTS02 CURRENT GOOD MANUFACTURING PRACTICES L T P C

1 0 0 1

Course Objectives:

To make the students to understand the good manufacturing practices

268

To make the students to gain knowledge on the quality management in

the pharmaceutical industries

Course Outcomes:

Able to understand the good manufacturing practices

Ability to assure the quality in pharmaceutical industries

UNIT I 4

Introduction to GMP – Personnel - Premise and Equipment

UNIT II 4

Pharmaceutical Quality System - Quality Management - Quality Control

UNIT III 5

Production - Contract Manufacture and Analysis - Outsourced activities –

Documentation – Complaints and Product Recall.

UNIT IV

2

Case study

TOTAL: 15 PERIODS

REFERENCE BOOKS:

1. Settle, M.J.A., “Current Good Manufacturing Practices: Pharmaceutical,

Biologics, and Medical Device Regulations and Guidance Documents

Concise Reference”, Createspace, 1st Edition, 2009.

2. Potdar M.A., “cGMP Current Good Manufacturing Practices for

Pharmaceuticals”, PharmaMedPress, 1st Edition, 2008.

3. Smit S. D., “Good Manufacturing Practice in Transfusion Medicine”,

Springer, 1st Edition, 1994.

MEPCO SCHLENK ENGINEERING COLLEGE, …. 15MB203 Immunotechnology 30 ... Current Good Manufacturing...

Documents

Transcript of MEPCO SCHLENK ENGINEERING COLLEGE, …. 15MB203 Immunotechnology 30 ... Current Good Manufacturing...