Materi 1 Tsf

7/23/2019 Materi 1 Tsf

http://slidepdf.com/reader/full/materi-1-tsf 1/31



SALEP / UNGUENTUM

Defnisi Salep :

Sediaan setengah padat yg mdhdioleskan & dignakan s!g o!at la"#

$ahan o!atnya h"s la"t/ te"dispe"sihomogen dlm dasa" salep %ehiklm'yg (o(ok



$ahan Dasa" Salep

$e"dasa"kan komposisi dasa" salep dptdi!agi:

• Dasa" salep hid"oka"!on •

)aselin ptih * aselin kning• Pa"a+n en(e"* pa"a+n padat

• Minyak tm!h,an

• Dasa" salep se"ap• Adeps lanae* lanolin

• Ungentm simple- %malam kning : ol#sesami .0:10'

• Dasa" salep dapat la"t dlm ai"• PEG %polyethylenegly(ol' ata (amp"an PEG

• T"aga(ant * PGA



• Dasa" salep dapat di((i dg ai"

– Dasa" salep emlsi tipe M/A sptanishing ("eam

–Emlsi2ying oinment $#P

3/ emlsi2ying 4a- 00

aselin al!m 500

pa"afn li6id ,00

emlsi2ying 4a- : 3/ (etostea"yl al(ohol 7

na la"il sl2at 80

a6adest 9 ml



At"an Pem!atan Salep

At"an mm :

8# at yg dpt la"t dlm dasa" salep*dila"tkan* !ila pe"l dg pemanasan

"endah,# at yg tdk (kp la"t dlm dasa" salep*

le!ih dl dise"!k & diayak % ayakan no800'

# at yg mdh la"t dlm ai" & sta!il*dila"tkan dl dlm ai" yg te"sedia kmdtam!ah dasa" salep lain

9# $ila dasa" salep di!at dg pele!"an* mk

(amp ts! h"s diadk sampai dingin



;a"a Pem!atan Salep

8# at/ $ahan padat la"t dlm dasa"salep

a# ;ampho"a* mentol* na2tol* 2enol* gai(ol*

thymol• Dila"tkan dlm dasa" salep yg sdh di(ai"kan

dlm !otol ka(a

• $ila ada minyak lemak %ol#sesami' maka

(ampho"a dila"tkan dlm minyak ts!• $ila t<dapat !<sama mentol* salol* thymol yg

dpt men"nkan titik le!"nya* mk (ampho"adi(amp" & dige"s dg =at>=at ts! sampaim<(ai"* kmd di ? !ahan dasa" salep sedikit,

• ;ampho"a ? spi"its 2o"t* kmd dige"s dg !hn



!# Pellidol

> dila"tkan !e"sama>sama !hn dasa" ygdi(ai"kan/dile!" %la"t @ dlm aselin & 1@dlm minyak lemak'

> !ila mlahnya !esa"* dila"tkan dlm dasa"salep yg sdah di(ai"kan

(# Bodim> ditam!ah spi"# Co"tio" %etano 75 @' * dige"s dg

!hn dasa" salep> ditam!ah B ? ai"* spt pem!atan Ung#Bodii %mlahai" yg ditam!ahkan dik"angkan pd !agian dasa"salep'



,# $ahan padat la"t dlm ai"a# A"gentm (olloidal %(ola"gol'

dige"s lama dg ai" sama !anyak sampai la"t

!# A"gentm p"oteini(m %p"ota"gol'dita!"kan diatas ai" sama !anyak* !ia"kan 0<*kmd ge"s dg dasa" salep# $ila ada gly(e"in*p"ota"gol dpt dige"s langsng

(# Tannin !ila ai" yg te"sedia tdk (kp * hanya dise"!k

& dige"s dg dasa" salep



d# Ekst"ak kental

> dige"s dl dg sedikit ai"* spt !elladonae

e-t"a(tm* hyos(yami e-t"a(tm

> !ila dlm "esep ada gly(e"in* dpt dipakai tkmengge"s ekst"ak

e# 3atanhiae e-t"a(tm

dita!" dl dg ai" sama !anyak* !ia"kan 85 *

!a" dige"s & diadk



2# Adanya iodim / tanin dg ga"amalkaloida didlm la"tan a/ m<endapkanalkaloid * maka

keda =at ts! h"s dipisah & di(amp" sendi"i, dgse!agian dasa" salep*kmd kedanya !a"di(amp"

# $ahan padat tdk la"t lemak & ai"(ontoh : zinci oxydum, acidum boricum

=at ts! dise"!kkan dl dg pengayak no800* kmd diadk dg !ahan dasa" sampai

homogen



9# $ahan o!at yg dimaskan te"akhi"a# B(htyol* k dige"s lama a/ td pemisahan

!# $alsam %pe" !alsem'& minyak atsi"i/

minyak mdh mengap(# Ai"* aga" pe"m mo"ti" tdk li(in

d# Gly(e"in* ska" dise"ap o/ !hn dasa"

e# L;D %li6o" (a"!onatis dete"gent'

2# $ahan o!at !tk (ai"

g#



• $ahan dasa" !e"!entk F padat – )aselin* adeps lanae ata lanolin

– Dg men(amp" langsng !hn o!at dg !hndasa"* diadk sampai homogen

• $ahan dasa" !e"!entk padat – ;e"a aa/al!a* pa"a+n solid* (a"!o4a-* asam

stea"at* setil alkohol

– $hn dasa" ts! h"s dile!" dl !e"sama dg !hn

dasa" yg !e"!tk (ai" ata F padat* sth melelehdiadk ad dingin

– Hika !hn yg dile!" k"ang !e"sih* dpt disa"ingdg kasa %!hn ts! dile!ihkan 80>,0 @'



Pem!atan salep dg !hnkhss• Ilem (a(ao

– Hika J 80@ : dilelehkan tapi se!elmmen(ai" t"nkan da"i 4ate" !ath* ?

minyak /masa salep* dige"s homogen – Hika K 80 @ : di!at spt pd pem!atan

salep dg pele!"an

• $alsanm pe"ianm

angan ikt dipanasi* tam!ahkan pdmasa salep yg telah dingin & di(amp"te"akhi"



• $ahan o!at dlm salep yg tdk !olehdila"tkan : – Phenol

– in(i sl2as

– Il#ie(o"is aselli %minyak ikan'

– Anti!iotik %a#l penisilin0



;ontoh "esep

3/ (ampho"a 8

aselin a 7

S#ngt (ampho"a

3/ (ampho"a 8ol#(o(os 8

adeps lanae 8

m#2 ngt

3/ alii iodi lanolin 8

ngt#simple- ad 0

3/ p"o(ain ;l 0*8

Adeps lanae

in(i o-yd

a6a "osae 8

aselin ad 0

3/ (o(ain ;l 0*85

e-t"a(t !elladona 0*,5

iodii 0*5

lanolin

aselin a aa 80

s# ad s# e-t



;ontoh "esep

3/ "eso"(in 0*

sl2" pp ,*5

(eta(em

ol# (a(ao

ol# sesami ,5 se

3/ sl2adia=in,*5

=in(i o-ydi5

ol#sesami ,0a(id !o"i( 9

aselin8

Ungentm olei ie(o"is aselli

3/ olei ie(o"is aselli 90

(e"a aa 80

aselin aa 50

Ungentm a(idi !en=oi(i eta(idi sali(yli(i

3/ a(idi !en=oi( 5

a(idi sali(yl 5

lanolin 95

aselin95

s##e



Pasta

• Pasta !e"lemak – salep yg mengandng le!ih da"i 50@

=at padat/se"!k

– !hn dasa" : aselin* pa"a+n li6id – "n mlah lemak le!ih sedikit d"pd

se"!k* spaya homogen mk !hn dasa"ts! dileleh kan te"le!ih dl

– M"p salep yg te!al* kak*& tdk melelehpd sh !adan



• Pasta ke"ing – Pasta yg !e!as lemak mgd 0 @ =at

padat/se"!k spt nI* tal(* ;a (a"!onas

– Spy tdk md ke"ing salep ditempatkanpd tempat yg kedap & di? !entonit s!gsta!ilisato"

• Pasta pendingin – M"p (amp se"!k* minyak lemak &

(ai"an !e"ai"* dikenal dg Osalep tigada"a



;ontoh pasta

Pasta !e"lemak

3/ "eso"(in 5

sl2" 5nI 90

pa"a2 li6 80

(etostea"ylalkohol8,

as a ad 800

Pasta ke"ing3/ !entonit 8

sl2" pp ,



Ditina da"i kegnaan dlm te"api*salepdikelp :

• Salep epide"mis

Utk melindngi klit/mengo!ati epithelim* dgehiklm : aselin/ (amp hid"oka"!on

• Salep mkosa/diade"mik

Melindngi/mengo!ati mkosa* dg ehiklm :

(amp aselin 80>,0@* adeps lanae• Salep endode"mik

penet"asi le!ih dlm da"i pe"m klit dg ehiklm :!"p lemak/ (amp !!"p !hn yg mi"ip dg lemak klit

mansia



Salep epidermik

3/ a(id sali(yl 0*

sl2" pp 8*,

as a ad 0

s#s#e-t

Salep u/ mukosa

3/!en=o(ain 0*8

tanin

adeps lanae 80

as a ad 50

Salep endodermik

3/ menthol 80methyl sali(yl 80

adeps lanae ad 800

m2 ngt



Pe"sya"atan salep yg !aik

• Sta!il s(" fsika & kimia

• I!at h"s te"!agi me"ata* tdk !olehada !ag pa"tikel yg kasa"

• a"s mdah dioleskan

• $asis salep tdk me"angsang klit

•

Salep dk !oleh menge"ing• Tdk !e"!a tengik



;3EAM

• Defnisi ;"eam :

sediaan F padat !e"pa emlsikental mgd tdk k"ang d" 0@ ai"*

dimaksdkan tk pemakaian la"

• Tipe ("eam –

;"eam tipe Q/I ata ai" dlm minyak – ;"eam tipe I/Q ata minyak dlm ai"



• Utk mem!at ("eam dignakan =atpengemlsi/emlgato" !"p s"2aktan : – T4een* span*

–

Na la"il sl2at – ;M;

– ning tel"* gelatin

– TEA stea"at

• Utk pensta!il di ? =at antioksidan %spt$T*$A' & penga4et %spt nipagin &nipasol'



etentan mm ("eam

• $asis ("eam h"s di!at dl * !a"!hn o!at dpt dige"s dg !hn o!at ygsdh adi

• Pe"at"an yg ada di ngentm tdk!e"lak di ("eam# Hadi 4alapn adao!at yg mdh la"t dlm ai" tdk pe"l

dila"tkan (kp dige"s hals kmdtam!ahkan !asis* ge"s homogen



Pem!atan !asis ("eam

• Di!at md , 2ase:2ase minyak %dile!"' &2ase ai" %dila"tkan'

• $hn F padat & padat spt lilin* aselin*

(e"a* as#stea"at* pa"afn solid* setilalkohol :

– dile!" !e"sama, diatas 4ate"!ath

• $ahan !e"!tk (ai" & !tk se"!k spt TEA*

p"opilenglikol* nipagin : – dila"tkan dlm ai" panas

• eda 2ase di(amp" panas>panas &diadk sampai te"!tk massa ("eam



;ontoh !asis anishing ("eam %type

o/4'

3/ as# Stea"at 89, le!" di atas 4!

Glise"in 800

!o"a- ,*5 TEA 80 ? ai" panas ad la"t

Nipagin 6s

A6a 150



;ontoh !asis (old ("eam %type 4/o'

3/ spe"ma(eti 8,*5

(e"a al!a 8,

pa"a2# Li6# 5!o"a- 0*5

a6adest 87 ml



ITT dlm ("eam

• Asam salisilat 8> @* ika J @ :

– k"im a/ "sak

• nI ? as salisilat dlm k"im %mgd ai"' :

– a/ te"!tk semen* k"n ai" tdk !isadihilangkan mk nI diganti dg TiI2

• Neomisin SI4 yg !<si2at asam ITT dg !asis

anishing ("eam %!<si2at sa!n'* mk h"sdiganti dg !asis net"al :sa<s ("eam



E2ek o!at lokal pd klit

• Antip""itik : meng"angi "asa gatal, – Menthol 0*,5 @

– Phenol 0*5 @

–

;ampho"a , @• Anti!akte"i & anti2ngi

– )io2o"m @

– Tet"a(y(lin ;l @

– ;hlo"ampheni(ol ,> @

– Nystatin 800#000 g



• e"atolitik – Asam salisilat 9 > 80@

– Sl2" 9 R 80@

–

3eso"sin , > 9 @• Antieksim

– id"o(o"tison a(etat 0*5 R 8@

• Antipa"asit – Lotio !en=il !en=oat 80>0 @

Materi 1 Tsf

Documents

Transcript of Materi 1 Tsf