Limfosit b and T y Ppt
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LIMFOSIT BDAN
LIMFOSIT TOleh:
Noorma Paramitha 44114130
Novi Latifa 4411413033
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SEL-SEL SISTEM IMUN
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SEL-SEL SISTEM IMUN SPESIFIK
1. Sel T
•. Sel aal el T a!alah !ari "m"m t"la#$ mema"%i
tim" &er'roliferai !i re$io "&%a'"ler
•.Sel aal it" a!alah !ari (D4 !a# (D )
•. Ter!iri !ari &er&a$ai "&et :• Sel Th *T hel'er+
• Sel T *T "''reor+
• Sel T!h,T! *!ela-e! h-'ere#itivit-+
• Sel T *-toto/i+
• Sel limfoit #aif *vir$i#+
• Sel Th0
• Sel e$"lator !a# efe%tor
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Activation of Lymphocytes inLymph Nodes
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Pe#-e&ara# Limfoi! Pa!a T"&"h Ma#"ia
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•F"#$i Sel T "m"m#-a :
•Mem&a#t" el B !alam mem'ro!"%ia#ti&o!i
•Me#$e#al !a# me#$ha#"r%a# el
-a#$ teri#fe%i vir"•Me#$a%tif%a# ma%rofa$ !alam
fa$oitoi
•Me#$o#trol am&a#$ !a# %"alita
item im"#
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2. Sel B• Per%em&a#$a# Sel B !alam "m"mt"la#$ a!alah a#ti$e# i#!e'e#!e# teta'i
'er%em&a#$a# ela#"t#-a memerl"%a#
ra#$a#$a# !ari a#ti$e#• F"#$i "tama el B a!alah mem'ro!"%i
a#ti&o!i
• Ata 'e#$ar"h Sel T el B &er'loriferai!a# &er!ifere#iai me#a!i el 'lama
-a#$ mam'" mem&e#t"% I$ -a#$ 'eifi%
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SIST2M IMN SP2SIFI
• SP2SIFI 5MOAL• Be#!a ai#$ el B &er'roliferai !a# &er%em&a#$ me#a!i el 'lama
mem&e#t"% a#ti&o!i me#tetraliir to%i# i#fe%i e%trael"ler
• SP2SIFI S2LL2
• Sel T
Pertaha#a# terha!a' i#fe%i i#trael"ler • SIST2M LIMFOID
• Tem'at 'emata#$a# el T !a# el B
B l-m'ho-te a#! 'lama ellT l-m'ho-te
5el'er,I#!"er *(D4+
S"''reor *(D)+
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Pertaha#a# 5"moral
A. om'leme#
a. F"#$i %om'leme#
1. Me#$ha#"r%a# el mem&ra# &a#-a% &a%teri (lisis)
6. Mele'a &aha# %emota%ti% -a#$ me#$erah%a# ma%rofa$ %e
tem'at &a%teri (kemotaksis)3. Me#$e#!a' 'a!a 'erm"%aa# &a%teri mem"!ah%a# ma%rofa$
"#t"% me#$e#al (opsonisasi) lal" mema%a##-a
&. Lar"t !alam %ea!aa# #o# a%tif !ia%tivai oleh a#ti$e#7
%om'le% im"#7 !& me!iator *&iolo$i% a%tif ata"'"# m!
e#8im "#t"% rea%i ela#"t#-a+. 9al"r a%tivai i#i eri#$ '"la !iertai !e#$a# %er"a%a#
ari#$a#
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Pertaha#a# Sel"ler
1. Fa$oit• Pa!a !aar#-a em"a el &erifat fa$oitoi
• No# 'eifi% mo#o#"%lier *mo#oit ma%rofa$+ !a#
'olimorfo#"%lier ata" $ra#"loit
• Al"r : %emota%i *a%tivai %om'leme#+ me#ela# mema%a#
*fa$oitoi+ mem&"#"h me#er#a *lii+
6. Ma%rofa$• Da'at hi!"' lama
• Mem'"#-ai &e&era'a $ra#"l !a# mele'a%a# &er&a$ai &aha# :
lio8im7 %om'leme#7 i#terfero#7 !a# ito%i# %o#tri&"i !alam SIN
!a# SIS
3. L;L *Large Granular Lymphocyte)• Me#$a#!"#$ &a#-a% ito'lama7 $ra#"l ito'lama a8"rofili%7
'e"!o'o!ia7 !a# #"%le" e%e#tri
• Berifat e'erti el N
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B a#! T (ell Ativatio#i$#ali#$ overvie<
Scharenberg et al.
Nat Rev Immunol.
2007
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(o#e="e#e of T>(ell Ativatio#
• Treme#!o" Proliferatio#• A#ti$e# 'l" o>tim"lator- i$#al *(D6)+ lea! to e#tr- i#to ell
-le a#! IL>67 IL>6 'ro!"tio#. IL>6,IL>6 lea! to 'ro$reio#
thro"$h ell -le.
• Ma#- ro"#! of 'roliferatio# *1 ell to tho"a#!+• Differe#tiatio# i#to effetor f"#tio#
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T-cell Activation
Signaling
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Stages of T lymphocyte development-I
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Maturation of T lymphocytes in Thymus
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Antigen Presenting Cells
•Macrophages/monocytes
•Dendritic cells (e.g., Langerhan’s cells)
•B cells
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T cells require APCs to respond toa specific Ag
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Selection of T lymphocytes in Thymus
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T>ell "&'o'"latio#
1+ (D4 T hel'er l-m'ho-te *T5+
> T5 l-m'ho-te reo$#i8e a#ti$e# o# the "rfae of AP( i#
aoiatio# <ith la II M5( mole"le
> The- are ativate! a#! erete everal -to%i#e
> There are t<o mai# "&et of T5 ell *T5I a#! T56+
> The t<o "&et are !iffere#tiate! o# &ai of the -to%i#e the-
'ro!"e
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1+ (D4 T hel'er l-m'ho-te S"&et
Th1 'ro!"e mai#l- :
> (-to%i#e of (MI a#! i#flammatio#
e.$. IFN>?7 TNF> @7 IL>3 a#! IL>6
T56 'ro!"e mai#l-:
> (-to%i#e that tim"late B>ell
> S"''reor -to%i#e
e.$. Il>47 IL>7 IL> a#! IL>10
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6+ (D) (-toto/i T>l-m'ho-te *(TL+
C The- o#tit"te 3 0o 'eri'heral T>ell
C (TL reo$#i8e a#ti$e# o# ""rfae of tar$et ell *i#fete!
AP( or other i#fete! #"leoti! ell+ i# aoiatio# <ith M5(>I
C The- are ativate! a#! %ill the vir" i#fete! ell or t"mo"r ell
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A#ti&o!ie 'ro!"e! &- B>ell of the imm"#e -tem
reo$#i8e forei$# a#ti$e# a#! mar% them for !etr"tio#
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Ativatio# of hel'er T ell
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Ativatio# of -toto/i T ell
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T (ell eo$#itio# of A#ti$e#
• eo$#i8e a#ti$e# 'e'ti!e fra$me#t &o"#! to'eiali8e ell "rfae mole"le o# a#ti$e#>'ree#ti#$ell *AP(+.
• Mole"le are e#o!e! &- maor hitoom'ati&ilit-
om'le/• Pe'ti!e are !i'la-e! to T ell a 'e'ti!e:M5(om'le/e
• T ell a#ti$e# ree'tor reo$#i8e 'e'ti!e:M5(
om'le/e• 2ah M5( mole"le a# &i#! #"mero" !iffere#t'e'ti!e
• T<o lae of M5( mole"le
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Maor 5itoom'ati&ilit- (om'le/
*M5(+ ;e#e Pro!"t
• (la I• A#ti$e# i ""all- e#!o$e#o" *e.$. viral 'rotei#+.
• (D)E -toto/i T l-m'ho-te *(TL+ reo$#i8e a#ti$e# i#
aoiatio# <ith la I M5( $e#e 'ro!"t o# AP(.
• (la II Mole"le• A#ti$e# i ""all- e/traell"lar .
• (D4E 5el'er T L-m'ho-te reo$#i8e a#ti$e# i# aoiatio# <ith
la II M5( $e#e 'ro!"t o# AP(.
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(ell"lar (oo'eratio# a#! A#ti$e#
eo$#itio#
APC ExtracellularAntigen
CD4+ HelperTLymphocyte
Class IIMHC-associatedantigen
+
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B (ell A#ti$e# eo$#itio#
• (ell "rfae imm"#o$lo&"li# ree'tor or B>ell ree'tor
*I$M a#! I$D+
• A#ti$e# o#tat i#itiate B>ell ativatio#7 lo#al e/'a#io#7
mat"ratio# to 'lama ell
• A#ti$e# ree'tor i i!e#tial to imm"#o$lo&"li# that <ill
"ltimatel- &e 'ro!"e!
Plasma ell
(!e"i#e$ %"om B-l m 'o te "o$es
B
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P e # $ e # a l a #
a # t i $ e #
o l e h
e L B
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B (2LL A(TIATION
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B>ell ativatio#
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Stages of lymphocyte development-I
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Stages of lymphocyte development-II
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Stages of lymphocyte development-III
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The Phases of cell !esponses
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-cell Activation Signaling
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Interface "et#een T and -cells
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(ell"lar (oo'eratio#
TH Ba#ti$e#
A#ti&o!- eretio#
&- 'lama ell
Plama (ell
A#ti$e# 'ree#ti#$ ell
A#ti$e# 'ree#tatio# to Ta#! B ell &- AP(
T ell ela&orate
-to%i#e to failitate B
ell 'roliferatio# a#!
mat"ratio#
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2ffetor Meha#im
• Meha#im that are "e! &- the imm"#e -temto elimi#ate 'atho$e# *or other "&ta#e+from the &o!-
• (ell"lar effetor meha#im• Ativate! T ell• Nat"ral %iller ell
• 5"moral effetor meha#im *a#ti&o!-+
• Ne"trali8atio#• O'o#i8atio#• (om'leme#t ativatio#• A#ti&o!->!e'e#!e#t ell>me!iate! -toto/iit- *AD((+
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2ffetor Ativit- A$ai#t Patho$e#
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Per&e!aa# a#tara Limfoit B !a# Limfoit T
In$ikato" Lim%osit T Lim%osit B
1. F"#$i &er'era# !alami#flamai7 a%tifaima%rofa$ !alamfa$oitoi7 a%tivai
!a# 'roliferai el B!alam mem&e#t"%a#ti&o!i7 erta'e#$e#ala# !a#'e#$ha#"ra# el -a#$teri#fe%i vir"
mem'ro!"%ia#ti&o!i
6. Aal Th-m" Bo#e Marro<
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o In$ikato" Lim%osit T Lim%osit B
. Str"%t"r !a#mar%er
ree'tor