Leveraging the Electronic Health Record for Clinical Research John P. Glaser, PhD Vice President and...
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Transcript of Leveraging the Electronic Health Record for Clinical Research John P. Glaser, PhD Vice President and...
Leveraging the Electronic Health Record for Clinical Research
John P. Glaser, PhDVice President and CIO
Partners HealthCare
July 21, 2008
A Vision for Personalized Medicine
EMRwith clinical
decision support
Genomic research
with high capacity IT
Integratedgenomic and
phenotypic data repository
Facilitated translational
research leading to
• Diagnostic discovery
•Drug development
Improvedindividualized
medicine&
pre / postsymptomatic
disease management
Consent Tracking System (CTS)
Research Patient Data Registry (RPDR)
Enterprise LIMS Superstructure (GIGPAD / PowerPath)
Genomic Knowledge Base (GeneInsight)
Genomic Variant Interpretation Engine (GVIE)
EnterpriseTissue Banking Infrastructure
Electronic Health Record (EHR)
Clinical Decision Support Rules Engine
Shared Pathology
Information Network (SPIN)
ClinicalResearch
I2B2(HIVE / RelNet /
Pharmacologic Surveillance)
Computational Cluster and Storage Resources
Partners Personalized Medicine Infrastructure
i2b2 Hive
Can SSRI Response be Predicted?
Costs of “High Throughput” Clinical Research
Post Market Medication Surveillance
Brownstein, PLoS ONE, 2007
Patient Genetic Profile
GMRGenetic Markers
State Mgmt.Genetic Assessments
Clinician Systems Enterprise Service Bus
Genetics Reference & Authoring Svcs.
Genetics Runtime Services Patient Genome Browser
CPOE
Decision Support
CDRGenetic Test Reports
LMR
Fully Genetics Enabled EHR Architecture
PEARGenetic-based Drug Allergies
Data Access
Assessment Engine
Knowledge Access
Bus. RulesMgmt. Sys.
Event/Workflow Engine
GeneInsight
Ensemble
VariantWire
Result Receiver
PEPRFamily History, Genetic-based Problems
GVIE
Master Order CatalogGenetic Test Coverage
PatientData
Warehouse
To Pt Data Warehouse
Organization
Harvard Partners Center for Genetics and Genomics– Scientific leadership– Laboratory operations– Initiated with $50M Harvard Medical School/Partners
commitment Informatics for Integrating Biology and the Bedside
– Medical informatics and bioinformatics core– $20M/5 Year NIH funding
Partners Information Systems– Software development– Research Patient Data Registry– $5M annual operating budget
Industry sponsorship– HP– Affymetrix
Governance
HPCGG– Scientific Director reports to the Dean, HMS and CEO,
Partners
– External Advisory Board
Information Technology– Quarterly meeting with Partners CEO, VP – Academic
Affairs, and CEO, Physician Network
– Bi-monthly IT operations meeting