2

NEW DRUGS

edited byJOHN FEELY MD FRCPI

Professor of Pharmacology and Therapeutics,Trinity College, and Consultant Physician,

St James's Hospital, Dublin

Published by the British Medical JournalTavistock Square, London WC1H 9JR

Contents

PageDrug handling and response 1

John Feely, MD, FRCPI, professor of pharmacology andtherapeutics, Trinity College, Dublin 2, and consultantphysician, St James's Hospital, Dublin 8Martin J Brodie, MD, FRCP, consultant clinicalpharmacologist, Epilepsy Research Unit, UniversityDepartment of Medicine and Therapeutics, WesternInfirmary, Glasgow Gil 6NT

Therapeutic drug monitoring and clinical trials 15Martin J Brodie, John Feely

Adverse reactions to drugs 29D N Bateman, MD, FRCP, consultant physician and readerin therapeuticsS Chaplin, MSc, MPS, staff pharmacist, NorthernRegional Drug Information Unit, Wolfson Unit ofClinical Pharmacology, University of Newcastle uponTyne, Newcastle upon Tyne NE1 7RU

Adverse drug interactions 40Martin J Brodie, John Feely

Prescribing for infants and children 56George W Rylance, MRCP, consultant in paediatrics andpaediatric clinical pharmacology, Children's Hospital,Birmingham B16 8ET

Prescribing for the elderly 65Cameron G Swift, PhD, FRCP, professor of health care ofthe elderly, King's College School of Medicine andDentistry, London SE5 8RX

Nitrates and antianginal drugs 74Derek Maclean, PhD, FRCP, senior lecturer, Departmentof Clinical Pharmacology and Pharmacology, NinewellsHospital and Medical School, Dundee DD1 9SYJohn Feely

CONTENTS

Calcium antagonists 80John FeelyTerence Pringle, MD, FRCPI, consultant cardiologist,Ninewells Hospital and Medical School, Dundee DD19SYDerek Maclean, John Feely

P Adrenoceptor antagonists (0 blockers) 92Derek MacleanAngus MacConnachie, BSC, MRPS, principal pharmacist,Department of Clinical Pharmacology andPharmacology, Ninewells Hospital and Medical School,Dundee DD1 9SYJohn Feely

Angiotensin converting enzyme inhibitors 106Alasdair Breckenridge, MD, FRCP, professor of clinicalpharmacology, University of Liverpool, New MedicalBuilding, Liverpool, L69 3BX

Diuretic treatment 114Derek Maclean, Angus MacConnachie

Thrombolytic treatment 128Terence Pringle, John Feely, Derek Maclean

Antiarrhythmic drugs 134W S Hillis, FRCP, senior lecturerB Whiting, MD, FRCP, professor, University Departmentof Medicine and Therapeutics, Stobhill General Hospital,Glasgow GL1 3UW

Drugs in cerebral and peripheral arterial disease 150Gordon D O Lowe, MD, FRCP, senior lecturer andconsultant physician, University Department ofMedicine, Royal Infirmary, Glasgow G31 2ER

Asthma and allergic rhinitis 164K Fan Chung, MD, MRCP, senior lecturerPeter J Barnes, DM, FRCP, professor, Department ofThoracic Medicine, National Heart & Lung Institute,Royal Brompton Hospital, London SW3 6LY

CONTENTS

Chronic obstructive airways disease and respiratoryinfections 181

K Fan Chung, Peter J Barnes

Peptic ulceration 199Donald G Weir, MD, FRCPI, regius professor of physic,Trinity College Medical School, St James's Hospital,Dublin 8

Gall stones 217Ian A D Bouchier, MD, FRCP, professor of medicine,University Department of Medicine, Royal Infirmary,Edinburgh EH3 9YW

Insulin 234J Niall MacPherson, FRCP, consultant, CrosshouseHospital, Kilmarnock KA2 OBEJohn Feely

Oral hypoglycaemic agents 250Norman R Peden, MA, FRCPEd, consultant physician andendocrinologist, Falkirk and District Royal Infirmary,Falkirk FK1 5QE

Vitamin D metabolites and analogues,bisphosphonates, danazol, and bromocriptine 263

Colin R Paterson, DM, FRCP, senior lecturer, Departmentof Biochemical Medicine, Ninewells Hospital andMedical School, Dundee DD1 9SY

John Feely

Lipid lowering drugs 277Patricia O'Connor, MRCPI, lecturer, department ofpharmacology and therapeutics, Trinity College, Dublin2, and Lipid Clinic, St James's Hospital, Dublin 8John FeelyJames Shepherd, MD, MRCPath, professor, Department ofPathological Biochemistry, Royal Infirmary, GlasgowG32 2ER

Anxiolytics and hypnotics 293Brian R Ballinger, FRCPEd, FRCPsych, consultantpsychiatrist, Royal Dundee Liff Hospital, Liff, DundeeDD2 5NF

CONTENTS

Antidepressant drugs 301Brian R Ballinger, John Feely

Anticonvulsant drugs 309D L W Davidson, FRCPEd, consultant neurologist,University Department of Medicine, Ninewells Hospitaland Medical School, Dundee DD1 9SY

Centrally acting drugs 323D N Bateman, S Chaplin

Non-steroidal analgesic and anti-inflammatorydrugs 330

George Nuki, FRCP, professor of rheumatology,University of Edinburgh, Rheumatic Diseases Unit,Northern General Hospital, Edinburgh EH5 2DRThomas Pullar, MD, MRCP, honorary consultantrheumatologist, Yorkshire Regional Health Authority,senior lecturer in clinical pharmacology, University ofLeeds, and honorary consultant physician, GeneralInfirmary, Leeds LSI 3EX

Controlling symptoms in advanced cancer 345T D Walsh, MSC, FACP, director, Palliative Care Service,Cleveland Clinic Foundation, Cleveland, Ohio 44195,USAT S West, OBE, MB, medical director, St Christopher'sHospice, London SE26 6DZ

Acne and psoriasis 359G M Murphy, MD, MRCPI, consultant dermatologist,Beaumont Hospital, Dublin 9M W Greaves, MD, FRCP, professor, Institute ofDermatology, St Thomas's Hospital, London SE1 7EH

Anti-infectives 369Roger Finch, FRCP, FRCPath, consultant and seniorlecturer in microbial diseases, University of Nottingham,City Hospital, Nottingham NG5 1PB

CONTENTS

Antiviral and antifungal drugs 381P G Davey, MD, MRCP, senior lecturer in clinicalpharmacology and infectious diseases, Ninewells Hospitaland Medical School, Dundee DD1 9SY

Drug overdosage and poisoning 400L F Prescott, MD, FRCPEd, consultant physician andprofessor of clinical pharmacology, Regional PoisoningTreatment Centre and University Department of ClinicalPharmacology, Royal Infirmary, Edinburgh EH3 9YW

Index 411