Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15

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Inhibitors of Cell wall and Protein Synthesis BDS Semester III

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Transcript of Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15

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Inhibitors of Cell wall and Protein Synthesis

BDS Semester III

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Objectives

• By the end of this lecture you should be able to:

• Classify the major cell wall and protein synthesis inhibitors

• Understand their mechanism of action.

• Explain resistance mechanisms against these antimicrobials.

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Carbapenems

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Limitations of Penicillins

• Limited effectiveness against many gram negative rods

• Hydrolysis by gastric acid

• Inactivation by beta- lactamases

• Hypersensitivity reactions

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Carbapenems

•Monobactam

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1. Aminoglycosides

2. Tetracyclins

Inhibition of Protein Syntesis

1. Chloramphenicol2. Erythromycin3. Clindamycin4. Linezolid5. Streptogramins

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