Inhibitors of Cell wall and Protein Synthesis
BDS Semester III
Objectives
• By the end of this lecture you should be able to:
• Classify the major cell wall and protein synthesis inhibitors
• Understand their mechanism of action.
• Explain resistance mechanisms against these antimicrobials.
Carbapenems
Limitations of Penicillins
• Limited effectiveness against many gram negative rods
• Hydrolysis by gastric acid
• Inactivation by beta- lactamases
• Hypersensitivity reactions
Carbapenems
•Monobactam
1. Aminoglycosides
2. Tetracyclins
Inhibition of Protein Syntesis
1. Chloramphenicol2. Erythromycin3. Clindamycin4. Linezolid5. Streptogramins
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