ETER METRAKOS, FRCSC, FACS CURRICULUM · PDF filePeter Metrakos Page 1 out of 42 Last Updated...

Peter Metrakos out of 42 Last Updated on 2/15/2010

PETER METRAKOS, FRCSC, FACS CURRICULUM VITAE

A. IDENTIFICATION

NAME: Peter Metrakos

OFFICE ADDRESS: Royal Victoria Hospital, Department of Surgery687 Pine Avenue West, Suite S10.26Montreal, QuebecCanada H3A 1A1

TELEPHONE: (514) 843 1600FAX: (514) 843 1503CLINIC: (514) 904 0666

E-MAIL: [email protected]

Peter Metrakos of 42 Last Updated 2/15/2010

B. EDUCATION

Undergraduate Education

1979 – 1982 McGill University, MontrealFaculty of ScienceB. Sc., Microbiology and ImmunologyGreat Distinction

Medical

1983 – 1987 McGill University, MontrealFaculty of MedicineM D. C M.

Graduate

1987 – 1989 Assistant Resident, General SurgeryMcGill University, Montreal

1989 – 1992 Research Fellow, Experimental SurgeryAcute Pancreatitis and Islet TransplantationSupervisors: Dr. L. Rosenberg, Dr. G. M. Fried, Dr. W. P. DuguidMontreal General HospitalMcGill University, Montreal

1992 – 1994 Chief Surgical Resident, General SurgeryAdministrative Chief ResidentMcGill University, Montreal

Post Graduate Training

1994 – 1995 Fellow Liver/Kidney/Intestinal Transplant SurgeryUniversity of Western Ontario, University HospitalLondon, Ontario

1995 – 1996 Fellow, Pancreas/Islet Transplant SurgeryUniversity of Minnesota, University HospitalMinneapolis, Minnesota

Professional Certifications 2002 License to practice in the State of Vermont (2002-420010480)

1996 License to practice in the Province of Quebec(96296, June 6, 96)

1995 Certificate of Liver and Kidney TransplantationUniversity of Western Ontario

1995 Certificate of Registration for Independent Practice in the Province of Ontario (68374, Dec 21, 1995)


1995 Corporation Professionnelle des Médecins Spécialistes du Québec (CPMSQ)

1994 Fellow of the Royal College of Surgeons of Canada (FRCSC)

1990 Licentiate of the Medical Council of Canada (70788, Aug 2/90)

C. APPOINTMENTS

University

2003 – Present Associate ProfessorDepartment of SurgeryFaculty of MedicineMcGill University

2003 – Present Associate MemberDepartment of Anatomy and Cell BiologyFaculty of MedicineMcGill University

2001 – Present Program Director, Fellowship ProgramTransplantation and Hepatic, Pancreatic and Biliary Surgery Department of SurgeryMcGill University

2000 – Present DirectorMcGill University Liver Tumor Network

1997 – 2003 Coordinator, Royal Victoria HospitalPractice of Medicine Clerks Surgical Undergraduate EducationFaculty of MedicineMcGill University

1997 – Present InvestigatorDivision of Experimental SurgeryDepartment of SurgeryMcGill University Health Center

1996 – 2003 Assistant Professor of SurgeryMcGill University

HospitalChairman, Multi-Organ Transplant Mortality & Morbidity RoundsMcGill University Health Center

Chairman, Neuroendocrine Tumor boardMcGill University Health Center

Chairman, Hepato-pancreato biliairy and gastro-intestinal Tumor BoardMcGill University Health Center


2006 – Present Director, Multi Organ Transplantation,McGill University Health Center

2003 – Present Director of the L.D. MacLean surgical Research laboratoryHospital Royal VictoriaMcGill University Health Center

2003 – Present Director of Liver TransplantationMcGill University Health Centre

2003 – Present Associate SurgeonTransplantation, Pancreatic and Hepatobiliary Surgery Royal Victoria Hospital

2001 – Present Director, Hepatic, Pancreatic and Biliary SurgeryMcGill University Health Center

1999 – Present Assistant SurgeonDivision of General Surgery Montreal General Hospital

1998 – 2006 DirectorPancreas TransplantationMcGill University Health Center

1998 – 2003 Surgical DirectorKidney TransplantationMcGill University Health Center

1997 – Present Associate SurgeonPediatric Transplantation Montreal Children’s Hospital

1997 – Present Associate SurgeonHepatic, Pancreatic and Biliary SurgeryJewish General Hospital

1996 – 2003 Assistant SurgeonTransplantation, Pancreatic and Hepatobiliary Surgery Royal Victoria Hospital

Other2008 – Present Director of Hepato-Pancreato-Biliary and Transplant Surgery

Lutte Contre le Cancer – Ministère de la Santé du Quebec

D. SPECIAL AWARDS, HONORS, AND RECOGNITION

1997 – 2000 Fraser Monat Scholarship($30,000/year)

1996 – 1997 John Armour Fellowship($30,000/year)


1994 – 1996 McLaughlin Fellowship in Medicine($40,000/year)

1990 – 1992 Alan G. Thompson Research Fellowship($30,000/year)

1993 Fraser Gurd Basic Research AwardFirst Prize

1992 Canadian Society of Clinical Investigation Trainee Award

1990 Canadian Association of General SurgeonsResident Research Award

1985 – 1986 Medical Research Council of Canada Winter Student Research Bursary

1984 Medical Research Council of Canada Summer Student Research Bursary

E. TEACHING

McGill Courses

Undergraduate

Department of Surgery:ICM-C Tutor 4 students/year 1996-2000ICM-C Case Presentations 2 hours/year 1996-2000ICM-C “Diseases of the Liver and Spleen” 6 hours/year 1996-2000POMS “Diagnostic Work-up for Jaundice” 6 hours/year 1996-2000CaRMS “Blitz Day” 5 hours/year 1996-2000

Faculty of MedicineOSCE Exam 4 hours/ year 1996-2000

Post-Graduate

Division of Surgical Research, Faculty of Medicine Evaluator, Issues in Biomedical Research – Course #519-605B 2001-Present

- Review – Mark Lipsett “Reversal of diabetic hyperglycemia: Advanced biohybrid artificial pancreas transplantation”

- Review – Thomas Nicholson “Patient with blood in the stool”- Review – Svetlana Pidasheva “Epigenetic Regulation of Novel Human Liver-related Putative

Tumor Suppressor (LPTS) Gene in Hepatocellular Carcinoma (HCC) Cell Lines”- Review – Melanie Frigault “Pancreatic Adenocarcinoma and a Tumor Progression Model”

Division of experimental medicine, Faculty of MedicineExperimental and Clinical Oncology Course #516-635D 2001-Present

- Therapeutic Approaches to Liver Metastases 1.5 hours/year- Hepatocellular Carcinoma 1 hours/year


- Neuroendocrine Tumours 1 hours/year

Department of SurgeryMasters and PhD Advisory Committee 10 hours/year

1. José Pascual, MD – “Immunomodulatory effects of hypertonic saline in hemorrhagic shock: in-vivo alteration of leukocyte/endothelial dynamics, vascular permeability and tissue injury”

2. Giuseppina Campisi, M. Sc. – Mechanisms for reduced exudation of septic PMNs: Role of C5a and CD18-independent PMN exudation

3. Prosanto Chaudhury, MD – “The role of PECAM-1 in regulating polymorphonuclear neutrophil (PMN) transmigration and vascular leakage in sepsis”

4. Lorenzo Ferri, MD – Mechanisms for the reduced polymorphonuclear neutrophil (PMN) exudation in sepsis-induced systemic inflammation

5. Felicia Huang, MD – The clinical implication of reduced PMN exudation in sepsis: The second hit vs. the second front hypothesis

Department of Anatomy and Cell BiologyMasters and PhD Advisory Committee 10 hours/year

Continuing Medical Education

1. Royal Victoria Hospital, Surgical Grand Rounds – October 9th 1997 – Pancreas Transplantation

2. Jewish General Hospital, Endocrine Grand Rounds – January 15th 1998 – Pancreas Transplantation

3. McGill Endocrine Combined Rounds – November 19th 1998 - Pancreatic Transplantation

4. Organ Donation Symposium MUHC – April 20th 1999 - Success Rates in Pancreas Transplantation

5. Montreal General Hospital Grand Rounds – April 22nd 1999 – Planned Organ Donation

6. McGill Oncology Grand Rounds –September 15th 1999 – The Expanding Role of Liver Resection in the Care of Metastatic Cancer

7. McGill Anesthesia Grand Rounds – November 8th 1999 – Pancreas Transplantation

8. McGill University Cardio-Respiratory Rounds – April 4th 2000 – Pancreas Transplantation

9. McGill University Health Center Pharmacists Rounds – May 30th 2000 – Pancreas Transplantation

10. Jewish General Hospital Department of Medicine Grand Rounds – March 5th 2001 – Transplantation

11. Royal Victoria Hospital, Department of Oncology Grand Rounds – June 6th 2001 – Hepatomas

12. McGill University Health Center, Department of Surgery Grand Rounds – June 7th 2001 - Liver Resections

13. McGill University Health Center, Montreal General Hospital, Gastroenterology – April 3rd 2002 - Management of Hepatocellular Carcinoma

14. McGill University, Continuing Medical Education, TELS – April 11th 2002 – Transplantation: State of the Art

15. McGill University Health Center, Hematology/Oncology Rounds – April 17th 2002 – Management of Hepatocellular Carcinoma


16. McGill University Health Center, Obstetrics/Gynecology Residents – June 5th 2002 - Transplantation

17. McGill University Health Center, Gastroenterology Rounds – October 11th 2002 - Hepatomas

18. St. Mary’s Hospital, Combined Oncology Gastroenterology Rounds – February 7th 2003 - Hepatomas

19. Jewish General Hospital, Endocrinology Rounds– February 20th 2003 - Pancreas Transplants

20. McGill University Health Center, Anesthesia Rounds – April 30th 2003 - Liver Tumours

21. McGill University Health Center, Surgical Grand Rounds - October 30th 2003 - Neuroendocrine Liver Tumours

22. McGill University Health Center, Radiation Oncology Rounds – November 24th 2003 - Management of Liver Metastases

23. Jewish General Hospital, Grand Rounds – December 4th 2003 - Colorectal Liver Metastases

24. Lady Davis Institute, Jewish General Hospital, Endocrinology Rounds – March 11th 2004 - Neuroendocrine Tumours

25. McGill University Health Center Surgical Oncology – April 1st 2004 - Hepatocellular Carcinoma

26. McGill University Health Center – March 29th 2004 - Transplantation, Back to Basics

27. McGill University Health Centre, Nurses Teaching - August 13th 2004 - Colon Cancer Liver Metastases

28. McGill University Health Centre, Nurses Teaching – September 24th 2004 - Hepatitis C Management

29. Jewish General Hospital, Mini-Med, Community Education September 28th 2004

30. McGill University Health Center, Oncology Grand Rounds – January 26th 2009 – Management of Colorectal Cancer Liver Metastases

31. McGill University Health Center – Radiation Oncology Rounds – Management of Liver Metastases –February 6th 2009

Research Trainees Supervised

Post-doctoral Fellows

2000 - 2004 Abdel Majed-Khatib, PhD“Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1 mediated functions”

Research Fellows

2001- 2004 George Tzimas, MD, FACSMasters of Science in Experimental Surgery“Expression of pro-protein convertases in human colorectal cancer liver metastasis”


2004 - 2005 John Martinie, M.D.Predictive factors of the severity of ischemia/reperfusion injury during human liver transplantation

2004 - 2005 Tammy Znajda, M.D.Treatment algorithm for hepatocellular carcinoma

2004 - 2007 Prosanto Chaudhury, MDMasters of Public Health, Oxford University, Oxford, England“The role of preoperative chemotherapy in the management of colorectal cancer liver metastases”

2007 - Present Mazen Hassanain, MDPhD in Experimental Surgery“Improving Glycogen Liver Content Will Improve Morbidity and Mortality of Major Liver Resections”

Surgical Residents

1996 -1998 Jonathan Fridell M.D., M. Sc.(Co-supervised with Dr. Jean Tchervenkov)Masters of Science in Experimental Surgery“Characterization of pig anti-dog xenoantibodies and target xenoantigens on dog endothelial cells and dog platelets”

1997 - 2001 Nancy Morin M.D., M. Sc.Masters of Science in Experimental Surgery“Optimal immunosuppression protocol in a pig model of small bowel transplantation”

1996 Patrick Robinson, M.D.Development of a Hepatobiliary and Pancreatic Surgery Database

1999 - 2002 Michael Tan, M.D.Masters of Science in Experimental Surgery“The role of endothelial cell activation in an in-vitro model of xeno-islet

transplantation”

1999 - Present Antonio Di Carlo, M.D.(Co-supervised with Dr. Jean Tchervenkov)M. Sc. in Experimental Surgery“The role endothelial cell activation in an in-vitro model of discordant liver xenotransplantation”

2002 - Present Caroline Rochon, M.D.Ph. D. in Experimental Surgery“The expression of pro-protein convertases in hepatocellular carcinoma”

Students:

1997 - 1999 Kim Berman, B.Sc.“The expression of growth factor receptors on islet cells during culture”


1998 - 2000 Dimitris Kalavrouziotis“The Role of E and P selectins and intercellular adhesion molecule-1 (ICAM-1) in choline deficient ethionine supplemented diet induced severe acute necrotic pancreatitis”

1998 - 2000 Veronika Strmen, B.Sc.“The Role of E and P selectins and intercellular adhesion molecule-1 (ICAM-1) during mild cerulean induced pancreatitis”

2001 Rehan Kazmi“Optimizing Immunosuppression in an in vitro model of xenogeneic islet transplantation”

2002 - 2006 Anouk Emadali, M.Sc.PhD. in Experimental Surgery“Molecular profiling of ischemia reperfusion in human liver”

2002 - Present Tarek Boutros, M.Sc.PhD. in Experimental SurgeryMicroarray profiling of liver ischemia reperfusion injury

2004 - 2006 Cassandre BenayMasters in Experimental Surgery“Proprotein convertases in oncogenic transformation”

2007 - Present Philip Vourtzouris, B.Sc.Master in Experimental SurgeryThe role of adhesion molecules in the establishment of colon cancer liver metastasis

2008 – Present Jeanne Bouteaud, B.A & B.ScMaster in Experimental SurgeryCochrane review: Liver Transplantation as a treatment of Hepatocellular Carcinoma

2008 – Present Mamatha Bhat, MDMaster in Experimental MedecineComparaison of oncoprotein expression in explants of Hepatoma, HBV, and HCV cirrhosis

2008 – Present Otmane Nafidi

PhD in Experimental SurgeryColorectal Cancer primary tumour and liver metastasis cell lines

Invited Lectures, Talks, and Presentations

1. Vanderbilt University – September 24th 1998 - Current State of Islet Transplantation – Endocrine Rounds

2. Vanderbilt University – September 25th 1998 - Pancreas Transplantation in Non-uremic Type I Diabetic Patients– Transplant Rounds

3. Cité de la Santé de Laval – May 7th 1999 – Pancreas Transplantation: State of the Art


4. Quebec Association of General Surgeons – May 29th, 1999 – Transplantation of the pancreas and small bowel.

5. Congrès annuel du Conseil Professionnel de l’Association Diabète Québec, Quebec City – November 13th 1999 – Pancreas transplantation : state of the art

6. Canadian Transplant Society Annual Meeting – Mont Tremblant – March 2000 – Expanding the Organ Donor Pool: Non-Heart Beating Donors

7. Colon Cancer Conference & Workshops, McGill Cancer Centre – May 11th 2000 – The Expanding Role of Liver Surgery for Colon Cancer Hepatic Metastases

8. The 2nd Joint International Symposium, “New Perspectives in Medicine and Surgery for the New Millennium, Crete, Greece – July 21st 2001 – New Developments in Transplantation

9. Canadian Surgery Forum, Royal College of Physicians and Surgeons of Canada -–September 7th 2001 – Endothelial activation to xenogeneic stimuli

10. Canadian Surgery Forum, Royal College of Physicians and Surgeons of Canada – September 7th 2001 –Pancreas Alone and Pancreas After Kidney Transplantation

11. Canadian Surgery Forum, Royal College of Physicians and Surgeons of Canada – September 8th 2001 –What’s new in the treatment of Liver Metastases

12. Canadian Surgery Forum, Royal College of Physicians and Surgeons of Canada – September 8th 2001 –Case of nonresectable colorectal liver metastases

13. Cancercare Manitoba, Winnipeg, Hematology/Oncology Rounds, April 16th 2002 – Management of Hepatocellular Carcinoma

14. Quebec Transplant, Annual Coordinator Meeting, May 25th 2002, Living Donors: What’s New 2002

15. Queen Elizabeth II – Health Sciences Centre, Surgical Grand Rounds, May 29th 2002 – Management of Colorectal Liver Metastases

16. Queen Elizabeth II – Health Sciences Centre, Oncology Rounds, May 28th 2002 – Management of Hepatocellular Carcinoma

17. Premier Forum Québécois sur le donneur-vivant en greffe rénale, June 1st and 2nd 2002 – Chairperson

18. Toronto University Health Network, Hepatoma Group, September 30th and October 1st 2002.

19. Ottawa Regional Cancer Center, Update on the Management of Hepatocellular Carcinoma, December 3rd 2002

20. Ottawa Regional Cancer Center, General Campus Auditorium, Management of Colorectal Liver Metastases, December 4th 2002

21. The Expanding Role of Octreotide in Oncology, Mont Tremblant, “What is the optimal approach for the treatment of HCC?”, February 1st and 2nd 2003

22. London Health Sciences Center, Transplant and Hepatobiliary Rounds, Management of Hepatocellular Carcinoma, February 26th 2003


23. Hamilton Regional Cancer Centre, Medical Oncology Rounds, Management of Hepatocellular Carcinoma, February 27th 2003

24. Jewish General Hospital, Annual Mizne Lecture, Liver Transplantation, October 18th 2004

25. Department of Anesthesia – Hepatic Diseases and Liver Surgery, May 10th 2006

26. Centre hospitalier regional de l’outaouais, Ottawa Civic Hospital – Gastroenterology and Oncology –Current Management of Hepatocellular Carcinoma – April 11th 2007

27. Service de gastroenterologie de Sacré-Coeur - Management of Hepatocellular Carcinoma – April 25th

2007

28. Champlain Valley Physicians Hospital Medical Center - Current Management of CRC LiverMetastases – September 14th 2007

29. Hoffmann-La Roche Conferences – Montreal, Canada – Resection de metastases hepatiques chez les patients atteints de cancer colorectal – November 22nd 2007

30. Train the Trainers Evening, Chateau Versailles – Le Meridien – Mise à jour sur l’hepato carcinome –Management of Hepatocellular Carcinoma - November 28th 2007

31. 5th Annual ENETS Conference – Paris, France – Update on Neudoendocrine tumours – March 6th-8th

2008

32. Grand Rounds: State of the art management of Colorectal Liver Metastases – Clarian Health Hospitals – Indianapolis – September 3rd 2008

33. Role of transplantation in the treatment of hepatocellular carcinoma – Division of Transplantation –Clarian Health Hospitals – Indianapolis – September 4th 2008

34. Montreal City Transplant 1st Annual Symposium – Current Management of Hepatocellular Carcinoma– September 19th 2008

35. Canadian Liver Foundation English Support Group – Update on Liver Transplantation - Montreal -November 3rd 2008

36. Liver Transplant Forum – World Experience in Transplantation for hilar cholangiocarcinoma –November 21st 2008 – Toronto

Clinical Teaching

Department of SurgeryHepatobiliary Core Surgery Teaching Junior Residents 1 hour/year 1996-2000Transplant/Immunology Cores Residents 1 hour/year 1996-2000Pancreatic/Biliary Neoplasms Senior Residents 1 hour/year 1996-2000Pancreatic Transplantation Senior Residents 1 hour/year 1996-2000Hepatic Neoplasms Senior Residents 1 hour/year 1996-2000Practice Orals: Liver Tumours Chief Residents 3 hours/year 1996-2000Clinical and Hepatobiliary Tranplant Fellow 40hours/week 2000-Present

Department of Surgery


General Surgery Rounds, Purple Ward Rounds Chairman Weekly Round

McGill University Multidisciplinary Rounds and Tumor BoardsNeuroendocrine Tumour Board Chairman First Monday of the monthHepatopancreatobiliary and GI Tumor Board Chairman Weekly RoundsLiver Transplant Surgery Rounds Chairman Weekly RoundsLiver Transplant Mortality & Morbidity Rounds Chairman Monthly Rounds

Departments of Surgery and OncologyMcGill University Liver Tumour Network Practice Guidelines 10 hours/year

Clinical Fellows

2001- 2002 Hussein Hayati, MD, FRCSClinical Fellow in Transplantation/Hepatic, Pancreatic and Biliary Surgery

2002-2003 George Tzimas, MD, FACSClinical Fellow in Transplantation/Hepatic, Pancreatic and Biliary Surgery

2004-2005 Peter Horton, MDClinical Fellow in Transplantation/Hepatic, Pancreatic and Biliary Surgery

2005-2006 John Martinie, MDClinical Fellow in Transplantation/Hepatic, Pancreatic and Biliary Surgery

2005-2006 Prosanto Chaudhury, MDClinical Fellow in Transplantation/Hepatic, Pancreatic and Biliary Surgery

2006-2007 Dionisios Vrochides, MDClinical Fellow in Transplantation/Hepatic, Pancreatic and Biliary Surgery

2007-Present Mazen Hassanain, MDClinical Fellow in Transplantation/Hepatic, Pancreatic and Biliary Surgery

2008-Present Arena Goffredo, MDClinical Fellow in Transplantation/Hepatic, Pancreatic and Biliary Surgery

F. OTHER CONTRIBUTIONS

Editorial Advisory Board

Oncology Exchange 2000-Present The Journal for Canadian Cancer Professionals 2000-Present

Journals Ad Hoc Reviews

Canadian Journal of Surgery Canadian Medical Association Journal Journal of Gastrointestinal Surgery Annals of Surgery Transplantation Hepatology


American Journal of Transplantation

Grant Reviews

MUHC Research Institute Grant Review Committee 4 days/year 1998-2008

Chaired Scientific Sessions & Symposia

Montreal City Transplant Symposium September 19th 2008 - Symposium Chairperson – 1st Annual symposium

McGill University Transplant and Hepatopancreatobiliary Surgery Annual symposium October 16th 2003 - Symposium Chairperson - 1st Annual symposium –- Visiting Professors: Pierre-A.

Clavien, Department of Visceral and Transplantation Surgery, University of Zurich/Switzerland.

November 10th and 11th 2004 - Symposium Chairperson- 2nd Annual symposium - Visiting Professors: Professor ST Fan, SUN CY Chair Hepatobiliary Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital

November 9th and 10th 2005 - Symposium Chairperson - 3rd Annual symposium - Visiting Professors: Dr. Peter Stock, U. of San Francisco, Dr. David Iannitti, Brown University and Dr. Joseph Buell, University of Cincinnati.

November 15th and 16th 2006 - Symposium Chairperson - 4th Annual symposium –- Visiting Professors: Dr. Luca Cicalese, U. of Massachusetts, Dr. A. J. Tector, U. of Indiana, Dr. A. Koong, U. of Stanford.

November 7th and 8th 2007 - Symposium Chairperson - 5th Annual symposium - Visiting Professors: Dr Christophe Penna, Faculté de médicine Pierre et Marie Curie, Dr Riad Salem, Northwestern University

November 12th and 13th 2008 - Symposium Chairperson – 6th Annual symposium – Visiting Professors: Dr. Nigel Heaton, King’s College Hospital, England & Dr Kevork Peltekian, Dalhousie University.

Other: XVII World Congress of The Transplantation Society – July 17th 1998 – Chairperson of the Pancreas

Transplantation Session

4th Annual Canadian Liver Transplant Forum – March 3rd 2008 – Member of the steering committee

5th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocrine Tumor Disease –March 6th-8th 2008 – Menber of the Neuroendocrine Canadian Guidelines Update Committee – Paris, France.

Chairman of the Canadian Consensus on Colorectal Cancer Liver Metastases – November 13th 2008 –Montreal

Administrative Responsibilities Director of the Hepatopancreatobiliary and Transplant Surgery Fellowship 2000 – Present

McGill University

Membre du Conseil d’administration – PET Ville Marie – Montreal 2008-Present

Committees


Montreal General Hospital Trauma Committee 1993-1994

RVH Liver Transplant Recipient Selection Committee 1996-Present

RVH Kidney Recipient Selection Committee 1996-Present

Montreal Children’s Hospital Liver and Kidney Selection Committee 1997-Present

Surgical Undergraduate Committee 1997-Present

Residents Masters Advisory Committee 1998-Present

Search Committee for The Director of McGill University Surgery Division 1998

Task Force on Clinical Care – MUHC 1999-2000

Executive Committee, Clinical Affairs Surgical Services – MUHC 1999-Present

Surgical Services Management Committee – MUHC 2000-Present

Transplant Research Executive Committee – MUHC 2000-Present

MUHC Pancreas Transplant Committee 2000-Present

Canadian Neuroendocrine Tumor (NET) Advisory Committee 2000-PresentSponsored by Spey Pharmaceuticals

McGill Division of General Surgery – Executive Cttee 2001-Present

Conseil Québécois de lutte contre le cancer 2001-PresentComité d’évolution des pratiques Comité des sièges tumoraux Comité des mandats spécifiques (7 days/year)

Orthopedics Chair Review Committee – MUHC 2002

Allocation of Resources Committee – MUHC 2002

Clinical Trials Research Panel Member , Ontario Cancer Research Network 2003 Ministry of Enterprise, Government of Ontario, Translational and Clinical Research

MRSA Working Policy Group – MUHC 2003

Glen Site Task Force – MUHC 2004

Sous-comité complémentarité transplantation, CHUM/MUHC 2004-Present

AHPBA Membership Committee 2005-2007

Canadian Neuroendocrine Tumour Advisory Board – Novartis 2005-Present

Hepatobiliary-Transplantation Committee 2005-PresentCanadian Association of General Surgeons


HCC National Advisory Board 2007-PresentNexavar – Current treatment algorithms in HCC

Nephrology Search Committee for Director of Nephrology – MUHC 2008

RAD advisory committee - Novartis 2008-Present

AHPBA Program Committee 2008-present

Membership in Professional Societies

Canadian Medical Association American College of Surgeons (FACS) Fellow of The Royal College of Physicians & Surgeons of Canada (FRCS) Corporation Professionnelle des Médecins Spécialistes du Québec (CPMSQ) International Association of Pancreatology New York Academy of Science Cell Transplant Society International Association of Pancreas and Islet Transplantation Association of Academic Surgeons American Society of Transplant Surgeons International Hepato Pancreato Biliary Association American Hepato Pancreato Biliary Association American Association for Cancer Research Society for Surgery of the Alimentary Tract American Association for the Study of Liver Diseases

Other Professional and Scientific Contributions: Examiner - Surgical Oncology-Clinical Fellows 2008-Present

The Royal College of Physicians and Surgeons of Canada

Examiner – General Surgery 2009-PresentThe Royal College of Physicians and Surgeons of Canada

G. RESEARCH

Research ActivitiesPast:

1. Exocrine Pancreas: The effect of altered pancreatic secretion in animal models of acute pancreatitis, and the role of

cathepsin B in the early stages of acute pancreatitis. Regulation of enzyme processing and secretion in the rat pancreas and the effect of

somatostatin and cyclosporine on these processes. The role of adhesion molecules in the development of acute

pancreatitis. Comparison of mild and severe models of acute pancreatitis.

2. Islet Transplantation: The effect of micro-environment on survival and proliferation of islet cells.


Developing methods of long-term culture for islet cells in order to facilitate islet transplantation.

Introducing survival factors into islets via gene therapy, to increase survival of islet transplants.

Current:1. Xenotransplantation

The role of endothelial cell activation in a dog to porcine in-vivo and in-vitro model of liver transplantation.

The role of endothelial cell activation in a dog to porcine in vitro model of islet

2. Cancer metastasis Transplantation The role of adhesion molecules in the establishment of colon cancer liver metastasis.

Specifically the expression of E selectin in liver sinusoidol endothelial cells during the development of liver metastasis.

The expression of proprotein convertases in colon cancer liver metastasis and the effect of their inhibition on cancer progression.

3. Hepatocellular Carcinoma Clinical trial: The effect of intra-hepatic arterial chemoembolization pre-liver transplantation

on the outcome of patients with larger hepatocellular carcinoma. The effect of octreotide on hepatocellular cell line growth

4. Small Bowel Transplantation Project Development of an optimal immunosuppression protocol for small bowel transplantation.

Personal Support Awards

2000-2005 Bourse de chercheurs-boursiers-cliniciens-FondamentaleFonds de la recherche en santé du Québec Un modèle in vitro de xenotransplantation d’îlot: le role des cellules endothéliales($35,000 per year)

1997-2000 Fraser Monat ScholarshipThe Role of Adhesion Molecules in Mild and Severe Acute Pancreatitis ($30,000/year)

1996-1998 John Armour Fellowship Islet Survival Factors ($30,000)

1994-1996 McLaughlin Fellowship in Medicine - ($40,000/year)

1990-1992 Alan G. Thompson Research Fellowship - ($30,000/year)

Research Grants

Past

1996-1997 Principal Investigator Canadian Surgical Research Fund Grant for a project entitled “The Effect of Regenerating Rat Liver on Pancreatic Islet Proliferation”. ($10,000)


1996-1997 Principal Investigator Research Institute of the Royal Victoria Hospital Operating Grant for a project entitled “The Role of E and P Selectins and ICAM-1 During Mild and Severe Acute Pancreatitis”.($31,000)

1998-1999 Principal Investigator Fraser Fund Operating Grant “The Development of an Optimal Immunosuppression Protocol for Small Bowel Transplantation”($40,000)

1998-1999 Principal Investigator American Society of Colon and Rectal Surgeons Research Foundation Grant “The Development of an Optimal Immunosuppression Protocol in a Preclinical Model of Small Bowel Transplantation” ($20,000 US)

1999-2004 Co-Principal Investigator with Dr. Jean Tchervenkov Fujisawa entitled The role of endothelial cell activation in xenotransplantation($100,000 per year). Dr. Metrakos has 50% of the funds and wrote and conducts 50% of the research.

1999-2004 Co-Investigator with Dr. Pnina Brodt and Dr. Lesley Alpert Medical Research Council of Canada Grant “Tumor-endothelial call interactions in liver metastases” ($139,713/year). Dr. Metrakos wrote the clinical section of the grant and receives app. 15% of the funds to conduct his research.

2003-2005 Principal Investigator Fujisawa Research Grant“Molecular profiling of hepatic ischemia-reperfusion injury of human liver transplantation”($100,000/year)

2002-2005 Novartis, McGill University Tumour Network($20,000 per year)

Current:

2009-2012 Principal Investigator with Dr Prosanto ChaudhuryWyeth Research Grant for investigator initiated research“PET Scan as a screening tool for liver transplantation on patients with Hepatocellular Carcinoma”($175,000)

2009-2012 Principal InvestigatorBayer Health Care Division Research Grant investigator initiated research“A Phase II study of Sorafenib in Combination with 90Y - Radioembolization in Advanced Hepatocellular Carcinoma”($100,000)


Industry Sponsored

Principal Investigator

MCG0429, Phase II Study of Neoadjuvant 5-FU+Leucovorin+CPT-11 in Patients with Liver Metastases from Colorectal Adenocarcinoma

MCG0502, Phase III Randomized, Placebo-Controlled Study of Sorafenib in Patients with Advanced Hepatocellular Carcinoma

Thymo102700103, A randomized, controlled multi-center study of thymoglobulin induction therapy with a calcineurin inhibitor sparing regimen in liver transplant patients

A4061016, A randomized phase 2 study of the anti-angiogenesis agent AG)13736 in combination with chemotherapy-naïve advanced pancreatic cancer preceded by a phase 1 portion

A4061016, A randomized phase 2 study of the anti-angiogenesis agent AG)13736 in combination with chemotherapy-naïve advanced pancreatic cancer preceded by a phase 1 portion. Principal Investigator

Co-investigator FG-506E12-03, A Multicentre, 1:1 Randomized, Double Blind, Two Arm Parallel Group Study to

Evaluate and Compare the Efficacy and Safety of Modified Release Tacrolimus FK506E (MR4) Versus Tacrolimus FK506 in Combination with MMF (Cellcept) and Steroids in Patients Undergoing Kidney Transplantation

ML18423, A prospective, Open-Label, Multi-Center, Randomized Trial of the Efficacy and Safety of Long Term Calcineurin Inhibitor Free Maintenance Regimen with Mycophenate Mofetil and Sirolimus in Recipients of Orthoptic Liver Transplantic

FG-506E-11-03, A Multicentre, 1:1 Randomized, Double Blind, Two Arm Parallel Group Study to Evaluate and Compare the Efficacy and Safety of Modified Release Tacrolimus FK506E (MR4) Versus Tacrolimus FK506 in Combination with MMF (Cellcept) and Steroids in Patients Undergoing Primary Liver Transplantation

FG-506-14-02, A long-term follow-up Study to Evaluate the Safety and Efficacy in Transplant Recipients Treated with Modified Release Tacrolimus, FK506E(MR4), Based Immunsuppression Regimen

Thymo102700103, A randomized, controlled multi-center study of thymoglobulin induction therapy with a calcineurin inhibitor sparing regimen in liver transplant patients

McG 0502, A Phase III Randomized, Placebo-Controlled Study of Sorafenib in Patients with Advanced Hepatocellular Carcinoma

McG 0502LTF, Sorafenib Long Term Extension Program (STEP), Rollover study from McG 0502

Presentation

1. Metrakos P, Rosenberg L, Duguid WP, Fried GM. Does prophylactic Sandostatin prevent or diminish the severity of pancreatitis? Presented at the Canadian Association of General Surgeons, Toronto, 1990.


2. Metrakos P, Rosenberg L, Duguid WP, Fried GM. Dose related effects of Octreotide on normal pancreas and in Cerulein-induced pancreatitis. Presented at the Canadian Association of General Surgeons Research Forum, Mont Gabriel, Quebec, 1990.

3. Metrakos P, Rosenberg L, Duguid WP, Fried GM. Prophylactic Sandostatin potentates acute pancreatitis. Presented at the Surgical Forum of the American College of Surgeons, San Francisco, 1990.

4. Metrakos P, Clas D, Healy M, Rosenberg L. Stimulating New Islet Growth Will Reverse Diabetes. Presented at the Canadian Association Of Clinical Surgeons, Montreal, 1991

5. Metrakos P, Rosenberg L, Fried GM. Mechanism Of Octreotide-Induced Enzyme Accumulation in the Pancreas. Presented at the Canadian Association of General Surgeons Research Forum, Mont-Gabriel, Quebec, 1991

6. Metrakos P, Qi SJ, Vaidya R, Fried GM, Rosenberg L. The Effect of Sandostatin on Pancreatic Parenchymal Blood Flow. Presented at The Society of University Surgeons Residents Meeting, Cincinnati, Ohio, 1992.

7. Kakugawa Y, Metrakos P, Qi SJ, G. M. Fried, L. Rosenberg. Alterations in Regional Blood Flow in a Model of Chronic Pancreatitis. Presented at the Pancreas Club, San Francisco, 1992.

8. P. Metrakos, R. Vaidya, L. Hornby, G.M. Fried, L. Rosenberg. Sandostatin and Protein Processing in the Rat Pancreas. Presented at the Pancreas Club, San Francisco, 1992, Poster presentation at the American Gastroenterology Association, San Francisco, 1992.

9. P. Metrakos, S.J. Qi, D. Agapitos, L. Rosenberg. Isolation of Hamster Islets by Intraductal Collagenase infusion and Bovine Serum Albumin Density Gradient Purification. Poster presentation at the First International Congress of the Cell Transplantation Society. Pittsburgh, 1992.

10. L. Rosenberg, P. Metrakos, S.J. Qi, D. R. Rajotte. Trophic Stimulation of Adult Human Islets in - vitro. Poster presentation at the First International Congress of the Cell Transplantation Society. Pittsburgh, 1992.

11. P. Metrakos, S.J. Qi, R. Vaidya, G. M. Fried, L. Rosenberg. Effect of sandostatin on Splanchnic Regional Blood Flow. Presented at the Canadian Association of General Surgeons Research Forum, Chantecler, Quebec, 1992.

12. P. Metrakos, R. Vaidya, L. Hornby, G.M. Fried, L. Rosenberg. Cyclosporine and Protein Processing in the Rat Pancreas. The International Association of Pancreatology, Athens, Sept 1992.

13. Y. Kakugawa, P. Metrakos, S.J. Qi, G. M. Fried, L. Rosenberg. Pancreatic Blood Flow and pain in Chronic Pancreatitis. Canadian Royal College Meeting, Gastroenterology section, Ottawa, Sept 1992

14. P. Metrakos, L. Hornby, D. Tanguay, L. Rosenberg. Cyclosporine Blocks Islet Cell Proliferation By inhibiting ODC activity. Canadian Royal College Meeting, Canadian Society for Clinical Investigation section, Ottawa, Sept 1992.

15. S.Y. Yuan, P. Metrakos, W.P. Duguid, L. Rosenberg. Isolation and In - vitro Maintenance of Hamster Pancreatic Duct Fragments. American Pancreatic Association, Chicago, November 1992.

16. P. Metrakos, L. Hornby, L. Rosenberg. Cyclosporine and Islet Mass - Implications for Transplantation. The Association of Academic Surgeons, Montreal 1992


17. P. Metrakos, S.Y. Yuan, D. Agapitos, L. Rosenberg. Intercellular Communication and Islet Cell Proliferation. Society of University Surgeons, Seattle, 1993.

18. Y. Kakugawa, A. Jiad, P. Metrakos, L. Rosenberg. Endothelin Expression In Chronic Pancreatitis. Pancreas Club, Boston, 1993.

19. P. Metrakos, S.Y. Yuan, L. Rosenberg. Pancreatic Duct-Islet Interaction In-Vitro. International Association of Pancreas and Islet Cell Transplantation. Amsterdam, 1993.

20. N. Tchervenivanov, P. Metrakos, L. Rosenberg. Submucosal Transplantation of Islets. International Association of Pancreas and Islet Cell Transplantation, Amsterdam, 1993.

21. R. Vaidya, P. Metrakos, P.M. Bret, R.A. Brown, L. Rosenberg. Phase II Clinical Trial of Sandostatin for Acute Severe Pancreatitis (Ranson Score >4). Vancouver, CAGS, 1993.

22. P. Metrakos, S. Yaun, S.J. Qi, L. Rosenberg. Collagen Gel Matrix Promotes Islet Cell Proliferation. Cell Transplant Society, 1994.

23. N. Tchervenivanov, P. Metrakos, S. Yaun, L. Rosenberg. Metabolic Evaluation of Islets Transplanted into the Submucosal Space. Cell Transplant Society, 1994

24. Parent J, Metrakos P, Daly DS, Rosenberg L, Barken AN. The use of pancreatic enzymatic supplementation in the management of patients with pain and chronic pancreatitis - A randomized, double blind, cross-over, placebo controlled trial. Canadian Association of Gastroenterology, 1994.

25. Fryer JP, Metrakos P, Verran D, Asfar S, Pelz D, Fortier M, Ghent C, Wall W. Is central pontine myelinolysis a manifestation of cyclosporine neurotoxicity? American Society of Transplant Physicians -annual scientific meeting. May 14-26, 1995. Chicago, Illinois.

26. Asfar S, Metrakos P, Fryer J, Verran D, Ghent CN, Grant D, Wall W. An analysis of late deaths after liver transplantation. Joint Congress on Liver Transplantation. September 27-30,1995. London, England

27. Verran D, Fryer J, Metrakos P, Asfar S, Ghent CN, Grant D, Wall W. Biliary complications after liver transplantation. Joint Congress on Liver Transplantation. September 27-30,1995. London, England

28. Fryer JP, Jiang J, Zhong R, Metrakos P, Garcia B, Behme R, Grant D. Fourth International Symposium on Small Bowel Transplantation. October 15-17, 1995. Pittsburgh.

29. Metrakos P, Tortorelis D, Gillingham KJ, Majas AJ, Najarian JS. 123 Patients with Kidney Allografts Functioning > 20 Years. Poster at the American Society of Transplant Physicians, May 1996.

30. J Tchervenkov, J Tector, N Elias, J Barkun, P Metrakos, C Forbes, A Sherker. Recurrence-free long term survival following liver transplantation for hepatitis B using interferon -alpha pre-transplant and hepatitis B immune globulin post transplant. Presented at the American Surgical Association, Quebec City, April , 1997.

31. M. Cantarovich, J Fridell, J Tchervenkov, J-G Besner, M Deschenes, E Alpert, P Metrakos, J Barkun. Optimal Time Points for the Prediction of the Area-Under-the Curve in Liver Transplant Patients receiving Tacrolimus. Presented at The American Society of Transplant Physicians, Chicago, May, 1997.

32. AJ Tector, JA Fridell, T Watanabe, BM Jamison, P Metrakos, JI Tchervenkov. Pulmonary Injury Following Discordant Hepatic and Renal Xenografts. Presented at The 4th International Congress for Xenotransplantation, Nantes, France, September 1997.


33. AJ Tector, JA Fridell, T Watanabe, P. Metrakos, JI Tchervenkov. Coagulopathy in discordant hepatic xenotransplantation. Presented at The 4th International Congress for Xenotransplantation, Nantes, France, September 1997.

34. AJ Tector, JA Fridell, T Watanabe, BM Jamison, P Metrakos, JI Tchervenkov. Inflammatory mediators endothelin-1 and inducible nitric oxide synthase are upregulated in discordant hepatic xenografts. The 4th

International Congress for Xenotransplantation, Nantes France, September 1997.

35. Morin N, Metrakos P. Mixed Lymphocyte Reaction (MLR) by Fluorescent Activated Cytometric Analysis (FACS). The University of University Surgeons Resident’s Programs, Milwaukee Wisconsin, February 1998.

36. M. Cantarovich, J. Barkun, J-G Besner, P. Metrakos, E. Alpert, M. Deschênes, Z. Aalamanian and J.Tchervenkov. Cyclosporine Peak Level Provides A Superior Correlation With The Area-Under-The-Curve Than Trough Levels In Liver Transplant Patients Treated With Neoral. Poster at The International Congress on Immunosuppression

37. Piedboeuf B, Metrakos P, Fridell J, Gamache M. P-Selectin mRNA Expression Increases During Cerulein Induced Pancreatitis in Mice. The American Pediatric Society / The Society for Pediatric Research

38. Cantarovich M, Barkun J, Besner JG, Metrakos P, Deschenes M, Alpert E, Aalamanian Z, Tchervenkov J. Cyclosporine 2 Hour Blood Level: An Excellent Predictor of the Area Under-the-Curve in Liver Transplant Patients Treated with Neoral. Presented to the American Society of Transplant Physicians Annual Meeting Chicago IL, May 1998.

39. Cantarovich M., Barkun J, Metrakos P, Deschênes M, Alpert E, Tchervenkov J. Clinical Benefit of Neoral Dose Monitoring with Cyclosporine 2-HR Post Dose Levels Compared to Trough Levels in Stable Liver Transplant Patients. The Transplantation Society Meeting, July 1998.

40. Kumar U, Patel A, Suresh S, Metrakos P, Patel SC, Patel YC. Immunohistochemical Colocalization of Somatostatin Receptors 1-5 (hSSTR1-5) with Insulin, Glucagon, and Somatostatin in Human Islets. Annual Meeting of the US Endocrine Society, New Orleans, June 24-27 1998.

41. Deschênes M, Barkun JS, Cantarovich M, Alpert E, Metrakos P, Fernandez M, Tchervenkov JI. Liver transplantation in patients over 65 years of age: Mortality, morbidity and quality of life. American Association for the Study of Liver Disease, Chicago IL, November 1998.

42. Tchervenkov JI, Metrakos P, Barkun JS, Cantarovich M, Deschênes M, Alpert E, Tector AJ, Fridell JA, Aalamian Z. Rejection rate and cost of maintenance immunosuppression is reduced when using Tacrolimus compared to Neoral based immunosuppression in liver transplant recipients. American Association for the Study of Liver Disease, Chicago IL, November 1998.

43. Tector AJ, Fridell JA, Grienke D, Salazar J, Metrakos P, Tchervenkov JI. Discordant hepatic xenotransplantation in recipients with liver failure: A window of opportunity for clinical trials. American Association for the Study of Liver Disease, Chicago IL, November 1998.

44. Morin N, Lamoureux E, Lipman M, Tector AJ, Greinke D, Salazar J, Tchervenkov JI, Metrakos P. Donor-specific portal transfusion augments microchimerism in a porcine model of small bowel transplantation. VI International Small Bowel Transplant Symposium, Omaha NE, October 1999.


45. Cantarovich M, Barkun JS, Deschênes M, Metrakos P, Tchervenkov JI. Improvement of renal dysfunction secondary to cyclosporine in long-term liver transplant patients receiving mycophenolate mofetil and very low dose Neoral. American Society of Transplantation, Chicago IL. May 2000.

46. Di Carlo A, Tector AJ, Tan M, Fridell JA, Liu S, Soderland C, Barkun JS, Metrakos P, Tchervenkov JI. Comparison of cytokine profiles of endothelial activation in aortic and hepatic models of xenotransplantation. American Society of Transplantation, Chicago, IL. May 2000.

47. Di Carlo A, Tan M, Liu S, Metrakos P, Tchervenkov JI. Endothelial activation results in upregulation of interleukin-1A and endothelin-1 MRNA in pig-to-human liver xenotransplantation. Royal College of Physician and Surgeons, Edmonton, September 2000.

48. Cantarovich M, Metrakos P, Tchervenkov JI. Improvement of Acute Renal Dysfunction (ARD) in Solid Organ Transplant (Tx) Patients during Calcineurin Inhibitor “Holiday” without Rejection under Anti-CD25 Monoclonal Antibody (mAb) Coverage. ASN 33rd Annual Meeting, 2000.

49. Tan M, Di Carlo A, Tchervenkov JI, Metrakos P: Hepatic sinisoidal endothelium, compared to aortic endothelium, exhibits a unique pattern of IL-1, TNF-, and IFN- upregulation in response to xenogeneic islets in an in vitro dog-to-pig model of discordant islet xenotransplantation. Association of Academic Surgeons, Tampa November 2000.

50. Tan M, Di Carlo A, Liu S, Tchervenkov JI, Metrakos P. Glucocorticoids do not abrogate activation in response to islets in an in vitro dog-to-pig model of xenoislet transplantation. International Xenotransplantation Association Meeting, Chicago September 2001.

51. 51. Tchervenkov JI, Barkun J, Metrakos P, Alpert E, Cantarovich M, Tzimas G, DiCarlo A, Hayati H, Fernandez M, Deschenes M. Comparison of interferon alpha 2B and lamiduvine in preventing a recurrence of hepatitis B after liver transplantation. XIX International Congress of the Transplantation Society, Miami August 2002.

52. Tzimas G, Tchervenkov JI, Barkun J, Metrakos P, Deschenes M, Alpert E, Cantarovich M, Effectiveness of the combination of mycophenolate mofetil and minimal dose cyclosporine microemulsion in long-term liver transplant patients with renal dysfunction. XIX International Congress of the Transplantation Society, Miami August 2002.

53. Cantarovich M, Barkun J, Metrakos P, Fernandez M, Deschenes M, Di Carlo A, Alpert E, Tchervenkov J. Anti-Thymocyte Globulin Allows Delayed Introduction of Calcineurin Inhibitors with a Low Rejection Rate in Liver Transplant Patients with Postoperative Acute Renal Failure Requiring Dialysis. XIX International Congress of the Transplantation Society, Miami August 2002.

54. Barkun J, Tzimas GN, Fernandez M, Metrakos P, Deschenes M, Alpert E, Hayati H, Tchervenkov J. Intraoperative Transfusions and Early Survival in Liver Transplantation Recipients. XIX International Congress of the Transplantation Society, Miami August 2002.

55. Tchervenkov J, Barkun J, Metrakos P, Tzimas G, Di Carlo A, Hayati H, Alpert E, Paraskevas S, Fernandez M, Cantarovich M, Deschenes M. Risk Factors Determining Outcome in Liver Transplantation for Hepatitis C. XIX International Congress of the Transplantation Society, Miami August 2002.

56. Tzimas G, Metrakos P, Wexler M, Tchervenkov J, Barkun J, Valenti D, Alpert E, Deschenes M. Expanded Indications for Liver Transplantation of Hepatomas, Using Arterial Intrahepatic Chemoembolization with Carboplatin: Results of a Prospective Study. 53rd Annual Meeting of the American Association for the Study of Liver Diseases, Boston Massachusetts November 1-5 2002


57. Emadali A, Chevet E, Metrakos P. Molecular Profiling of Ischemia-Reperfusion in Human Liver. HUPO First World Congress, Human Proteome Organisation. Versailles, France November 21-24 2003.

58. Emadali A, Muscatelli-Giroux B, Tzimas G, Chevet E, Metrakos P. Molecular Profiling of Ischemia-Reperfusion in Human Liver. 3rd Annual McGill Biomedical Graduate Conference, Montreal, February 26th 2003.

59. Rochon C, Tzimas GN, Jenna S, Chevet E, Metrakos P. PC1 and PC2 convertase profile in neuroendocrine tumors. The Society of University Surgeons Residents Program. February 13, 2003. Houston, Texas.

60. Tzimas G, Hayati H, Tchervenkov JI, Metrakos P. Impact of Ureteral Implantation Technique on Urological Complication Rate After Adult Kidney Transplantation: The McGill Experience, Canadian Society of Transplantation, Lake Louise, Alberta, March 20-23, 2003.

61. Tzimas G, Deschenes M, Wexler M, Rochon C, Valenti D, Alpert E, Barkun J, Tchervenkov J, Metrakos P. Carboplatinum Chemoembolization of Hepatomas Prior to Liver Transplantation: A Pilot Study. Canadian Society of Transplantation, Lake Louise, Alberta, March 20-23, 2003

62. Feldman L, Anidjar M, Metrakos P, Stanbridge D, Fried GM, Carli F. Optimization of cardiac preload during laparoscopic donor nephrectomy: A preliminary study of central venous pressure versus esophageal doppler monitoring. Presented to SAGES, March 2003.

63. Khatib AJ, Chen A, Tzimas GN, Metrakos P, Chretien M. Analysis of human liver colorectal metastases (LCM) with Protein-chip arrays: New approaching way for potential biomarkers and/or target proteins identification. American Association for Cancer Research. Toronto, April 2003.

64. Tzimas G, Deschenes M, Wexler M, Rochon C, Valenti D, Alpert E, Barkun J, Tchervenkov J, Metrakos P. Transarterial Chemoembolization of Hepatomas Prior to Liver Transplantation: A Pilot Study. Accepted for presentation to the American Transplant Congress. Washington May 2003.

65. Tchervenkov J, Barkun J, Cantarovich M, Tzimas G, Paraskevas S, Deschenes M, Fernandez M, Metrakos P. The Impact of Pretransplant Renal Function and Delayed Introduction of Calcineurin Inhibitors in Liver Transplantation. Accepted for presentation to the American Transplant Congress. Washington May 2003.

66. Barkun J, Metrakos P, Cantarovich M, Tzimas G, Deschenes M, Alpert E, Paraskevas S, Tchervenkov J. Do Biliary Endoprotheses Decrease the Biliary Complication Rate After Liver Transplantation? Accepted for presentation to the American Transplant Congress. Washington May 2003.

67. Di Carlo A, Tan M, Liu S, Tector J, Metrakos P, Tchervenkov JI. Hepatic Endothelial Cell Activation in Xenotransplantation: Differential Upregulation of Two Transcription Factors. Presented at the American Transplant Congress, Washington, May 2003.

68. Cantarovich M, Barkun J, Deschênes M, Metrakos P, Alpert E, Wong P, Fernandez M, Tchervenkov JI. Early Renal Dysfunction Post-Liver Transplant is not Associated with Progressively Deteriorating Long-Term Renal Dysfunction. Presented at the American Transplant Congress, Washington, May 2003.

69. Tchervenkov JI, Barkun J, Cantarovich M, Tzimas G, Paraskevas S, Deschenes M, Fernandez M, Metrakos P. The impact of slightly reduced renal function and delayed introduction of calcineurin inhibitors in orthotopic liver transplantation. International Liver Transplantation Society, Barcelona, Spain, 2003


70. Cantarovich M, Barkun J, Metrakos P, DiCarlo A, Deschenes M, Alpert E, Tchervenkov JI. Anti-thymocyte globulin-induction allows delayed initiation of calcineurin inhibitors with a low rejection rate on liver transplant patients with low rejection rate in liver transplant patients with post-operative renal dysfunction. International Liver Transplantation Society, Barcelona, Spain 2003.

71. Metrakos P, WexlerM, Tchervenkov JI, Barkun J, Valenti D, Alpert E, Deschenes M. Carboplatin chemoembolization of hepatomas prior to liver transplantation. A pilot study. International Liver Transplantation Society, Barcelona, Spain 2003.

72. Tzimas G, Barkun J, Metrakos P, Deschenes M, AlpertE, Tchervenkov JI, Cantarovich M. Clinical benefit of varying doses of sirolimus in long-term heart transplant patients. International Liver Transplant Society, Barcelona, Spain 2003

73. Barkun J, Metrakos P, Cantarovich M, Tzimas G, Deschenes M, Alpert E, Paraskevas S, Tchervenkov JI. Do biliary endoprosthesis decrease the biliary complication rate after OLTx? Poster Presentation at the International Liver Transplantation Society, Barcelona, Spain 2003 –

74. Tchervenkov J, Cantarovich M, Paraskevas S, Fernandez M, Baran D, Mangel R, Schiff J, Lipman M, Metrakos P. Cadaveric renal transplantation and expanded criteria donors: Should we reassess their use? Accepted for presentation at the American Transplant Congress, Boston MA, May 2004.

75. Cantarovich M, Tchervenkov J, Giannetti N, Metrakos P, Paraskevas S, Barkun J, Mangel R, Deschenes M, Schiff J, Fontaine G, Coursol C, Besner JG. Variability of cyclosporine microemulsion C2 levels in fasting and fed solid organ transplant patients. Accepted for presentation at the American Transplant Congress, Boston MA, May 2004.

76. Rochon C, Metrakos P, Tchervenkov JI, Deschenes M, Alpert E, Fernandez M, Paraskevas S, Stein L, Barkun J. Endoscopic stenting as first line in duct of Lushka leak after choledochocystic anastomosis in 2 cases of liver transplantation. Canadian Transplant Congress, Mont-tremblant, QC 2004.

77. Tchervenkov JI, Barkun J, Cantarovich M, Tzimas G, Paraskevas S, Deschenes M, Fernandez M, Metrakos P. The impact of slightly reduced renal function and delayed introduction of calcineurin inhibitors in orthotopic liver transplantation. Canadian Society of Transplantation, Lake Louise, AB 2003

78. Cantarovich M, Tchervenkov JI, Metrakos P, Paraskevas S, Barkun J, Magel R, Deschenes M, Wong P, Fontaine G, Besner G. Differences in pharmacokinetic profiles between long-term liver and kidney/pancreas transplant patients receiving maintenance tacrolimus and mycophenolate mofetil. Canadian Society of Transplantation, Mont-Tremblant, QC Feb 2004.

79. Bergman S, Feldman LS, Carli F, Anidjar, Metrakos P, Tchervenkov J, Paraskevas S, Klassen D, Vassiliou M, Andrew C, Stanbridge D, Fried G. Convalescence after laparoscopic live donor nephrectomy. American Transplant Congress, Boston, MA May 2004.

80. Cantarovich M, Tchervenkov J, Giannetti N, Metrakos P, Barkun J, Paraskevas S, Mangel R, Sciff J, Fontaine G, Besner J-G. Variability of cyclosporine microemulsion C2 levels in fasting and fed organ transplant patients. American Transplant Congress, Boston, MA May 2004.

81. Cantarovich M, Barkun J, Tchervenkov J, Paraskesvas S, Sciff J, Mangel R, Deschenes M, Fontaine G, Coursol C, Metrakos P. Accuracy of cimetidine-corrected serum creatinine, creatinine clearance and calculated creatinine clearance to assess the glomerular filtration rate in long term kidney pancreas and liver tranplant patients. American Transplant Congress, Boston, MA May 2004.


82. Cantarovich M, Tchervenkov J, Metrakos P, Paraskevas S, Barkun J, Mangel R, Deschenes M, Schiff J, Wong P, Fontaine G, Besner J. Differences in Pharmacokinetic profiles between long-term liver and kidney/pancreas transplants receiving maintenance tacrolimus and mycophenolate mofetil. American Transplant Congress, Boston, MA May 2004

83. Tchervenkov J, Cantarovich M, Paraskevas S, Fernandez M, Baran D, Mangel R, Schiff J, Lipman M, Metrakos P. Cadaveric renal transplantation and expanded criteria donors: Should we reassess their use? Accepted for presentation at the American Transplant Congress, Boston MA, May 2004.

84. Tchervenkov J, Cantarovich M, Paraskevas S, Fernadez M, Baran D, Mangel R, Schiff J, Lipman M, Horton P, Metrakos P. Cadaveric Renal Transplantation and Expanded Criteria Donors: Should we reassess their use? Oral presentation at XX International Congress of the Transplantation Society, Vienna, Austria, September 2004.

85. S Bergman, LS Feldman, F Carli, M Anidjar, PP Metrakos, JI Tchervenkov, S Paraskevas, D Klassen, CG Andrew, MC Vassiliou, DD Stanbridge and GM Fried. Surgical recovery following laparoscopic live donor nephrectomy, Canadian Association of General Surgeons, Ottawa, ON, September, 2004.

86. J Martinie, M Fernandez RN, P Chaudhury, P Horton, T Znajada, J Tchervenkov, P Metrakos. Orthotopic Liver Transplantation for Hepatocellular Carcinoma in 89 patients: A Single Center Experience. Poster presentation at Canadian Transplant Congress, Banff AB, Mar 2005.

87. Horton P, Rochon C, Chaudhury P, Martinie JB, Znajda TL, Fernandez M, Barkun J, Metrakos P, Tchervenkov J. Antithymocyte Globulin (ATG) Induction Therapy in Hepatitis-C Positive Liver Transplant Recipients is Associated with Excellent Long Term Survival. Oral Presentation at Canadian Transplant Congress, Banff AB, Mar 2005.

88. Horton P, Chaudhury P, Martinie JB, Znajda TL, Rochon C, Fernandez M, Deschenes M, Metrakos P, Barkun JS, Cantarovich M, Tchervenkov J. Interferon Superior to Lamivudine at Preventing Heptatis-B Recurrence in Liver Transplant Recipients. Poster presentation at Canadian Transplant Congress, Banff AB, Mar 2005.

89. Horton P, Martinie JB, Rochon C, Chaudhury P, Znajda TL, Fernandez M, Deschenes M, Barkun JS, Metrakos P, Cantarovich M, Tchervenkov JI. Incidence of chronic renal failure in liver transplant patients receiving Thymoglobulin induction and delayed introduction of calcineurin inhibitors. Poster presentation at Canadian Transplant Congress, Banff AB, Mar 2005.

90. Rochon C., Horton PJ., Fernandez M., Chaudhury P., Paraskevas S., Metrakos P. Severe aortic arteriosclerosis (AS) as observed by the surgeon during organ harvesting: An important marker to assess cadaveric donor grafts for renal transplantation. Poster Presentation at Canadian Transplant Congress, Banff AB, Mar 2005

91. Tchervenkov J., Martinie JB., Chaudhury P., Horton PJ., Znajda T., BArkun J., Metrakos P. Liver transplantation for hepatocellular carcinoma outside Milan criteria: A single center experience. Poster Presentation at Canadian Transplant Congress, Banff AB, Mar 2005

92. Chaudhury P., Campisi G., Znajda T., Martinie JB., Rochon C., Horton PJ., Metrakos P. Outcomes of liver resection for colorectal metastasis following neoadjuvant chemotherapy. Poster presentation atAmerican Hepato-Pancreato-Biliary Association Annual Meeting, Fort Lauderdale, FL, Apr 2005.

93. Znajda T., Hayashi S., Horton PJ., Martinie JB., Chaudhury P., Jass J, Marcus V, Metrakos P. Histologic classification of remnants of hepatic metastases from colorectal cancer following


chemotherapy. Poster Presentation at American Hepato-Pancreato-Biliary Association Annual Meeting, Fort Lauderdale, FL, Apr 2005.

94. Horton PJ., Tchervenkov J., Znajda T., Martinie JB., Chaudhury P., Rochon C., Barkun J., Metrakos P. Antithymocyte globulin induction therapy in hepatitis C positive liver transplant recipients. Poster Presentation at American Hepato-Pancreato-Biliary Association Annual Meeting, Fort Lauderdale, FL, Apr 2005.

95. Horton PJ., Znajda T., Martinie JB., Chaudhury P., Rochon C., Metrakos P. Novel approach for resection of hepatic lesions situated between the middle hepatic vein and vena cava, preserving the middle hepatic vein. Poster Presentation at American Hepato-Pancreato-Biliary Association Annual Meeting, Fort Lauderdale, FL, Apr 2005.

96. Horton P, Barkun J, Cantarovich M, Rochon C, Fernandez M, Metrakos P, Tchervenkov J. Over 14 years Experience with Antithymocyte Globulin (ATG) Induction Therapy in Hepatitis C positive Liver Transplant Recipients. Oral Presentation at American Transplant Congress, Seattle WA, May 2005.

97. Rochon C., Horton PJ., Fernandez M., Chaudhury P., Paraskevas S., Metrakos P. Severe aortic arteriosclerosis (AS) as observed by the surgeon during organ harvesting: An important marker to assess cadaveric donor grafts for renal transplantation. Poster Presentation at American Transplant Congress, Seattle WA, May 2005.

98. Tchervenkov J, Barkun J, Horton P, Fernandez M, Cantarovich M, Deschenes M, Metrakos P. Early Predictors of Patient Survival after Liver Transplantation: Not all MELD Scores are created equal? Oral Presentation at American Transplant Congress, Seattle WA, May 2005.

99. Horton P, Barkun J, Rochon C, Fernandez M, Metrakos P, Tchervenkov J. Predictors of Graft Outcome in Hepatitis C Posititve Liver Transplant Recipients. Poster Presentation at American Transplant Congress, Seattle WA, May 2005.

100. Horton P, Barkun J, Rochon C, Fernandez M, Deschenes M, Metrakos P, Cantarovich M, Tchervenkov J. Twelve years Experience Preventing Hepatitis B Recurrence with Interferon and Hepatitis B-Immunoglobulin (HBIG) in Liver Transplant Recipient. Poster Presentation at American Transplant Congress, Seattle WA, May 2005.

101. Martinie JB., Horton PJ., Chaudhury P., Znajda T., Barkun J., Metrakos P., Tchervenkov J. Liver transplantation for hepatocellular carcinoma outside Milan Criteria: A single center experience. Poster Presentation at 12th Congress European Society of Organ Transplantation (ESCOT), Sept 2005, Geneva, Switzerland.

102. J. Tchervenkov, P. Chaudhury, M. Fernandez, J. Barkun, M. Cantarovich, P. Ghali, P. Metrakos, M. Deschenes. Long-term results with pre-transplant hepatitis B viral load reduction in liver transplantation: Comparison between Lamivudine and Interferon-Alpha 2B (IFN). Poster Presentation at Canadian Transplant Congress, March 2006, Tremblant, QC, Canada.

103. P Chaudhury, P Horton, P Metrakos, J Barkun, M Fernandez, P Ghali, M Deschenes, J Tchervenkov. Outcomes of Liver Transplantation in Hepatitis C Positive Patients with Hepatocellular Carcinoma. Poster Presentatio at Canadian Transplant Congress, March 2006, Tremblant, QC, Canada.

104. P Horton, J Barkun, P Chaudhury, M Fernandez, P Metrakos, J Tchervenkov. Liver Transplantation for Hepatocellular Carcinoma Outside Milan Criteria: A Single Center Experience. Poster Presentation at Canadian Transplant Congress, March 2006 Tremblant, QC Canada.


105. P Horton, J Barkun, P Chaudhury, M Fernandez, P Metrakos, J Tchervenkov. Predictors of Graft Outcome in Hepatitis –C Positive Liver Transplant Recipients. Poster Presentation at Canadian Transplant Congress, March 2006 Tremblant, QC Canada.

106. Martinie JB., Horton P., Chaudhury P., Metrakos P. Inital Evaluation of PET/CT in patients with hepatic metastases from colorectal carcinoma. Poster Presentation. American Hepato-Pancreato-Biliary Association Annual Meeting, March 2006, Miami, FL.

107. Chan G., Horton P., Barkun J., Martinie JB., Chaudhury P., Hill D., Marliss E., Metrakos P. CD34+ve Fibrous Sarcoma of liver associated with Hypoglycaemia. Poster Presentation. American Hepato-Pancreato-Biliary Association Annual Meeting, March 2006, Miami, FL.

108. Horton P., Chaudhury P., Martinie JB., Metrakos P. Liver Molding: A series of liver remnants derived from less than two segments. Poster Presentation at American Hepato-Pancreato-Biliary Association Annual Meeting, March 2006, Miami, FL.

109. Horton P., Martinie JB., Barkun J., Chaudhury P., Metrakos P. Hepatic Resection for Colorectal Metastases – A Canadian Perspective. Oral Presentation at American Hepato-Pancreato-Biliary Association Annual Meeting, March 2006, Miami, FL.

110. Horton P., Chaudhury P., Martinie JB., Metrakos P. A new anatomical definition of respectability based on multiple staged hepatic resections leaving part of segment IV and caudate. Poster Presentation. American Hepato-Pancreato-Biliary Association Annual Meeting, March 2006, Miami, FL.

111. P Chaudhury, P Horton, P Metrakos, J Barkun, M Fernandez, P Ghali, M Deschenes, J Tchervenkov. Hepatitis C and the Milan Criteria. Poster Presentation at to World Transplant Congress, Boston, MA, July 2006.

112. Tchervenkov J, Cantarovich M, Paraskevas S, Keith D, Fernandez M, Chaudhury P, Metrakos P. Improved actual renal allograft survival using Tacrolimus and Mycophenolate Mofetil: The impact is on kidneys with delayed graft function. Poster Presentation at Canadian Transplant Congress, Banff, AL, March 2007.

113. Chan G, Hassanain M, Chaudhury P, Znajda T, Metrakos P. The pathology of liver nodules after neoadjuvant chemotherapy is associated with outcomes for colorectal cancer metastases. Poster Presentation at American Hepato-Pancreato-Biliary Association Annual Meeting, Las Vegas, NV, April 2007.

114. Vrochides D, Hassanain M, Barkun J, Tchervenkov J, Chaudhury P, Metrakos P. “ Baseline Hepatic Arterial Doppler Increases Patient but not Graft Survival in Orthotopic Liver Transplantation.” Poster Presentation at the 15th Panhellenic Transplant Conference, Thassaloniki, Greece, December 2007

115. Vrochides D, Hassanain M, Barkun J, Tchervenkov J, Chaudhury P, Cantarovitch M, Deschenes M, Wong P, Ghali P, Metrakos P. Selection of Liver Tranplant Recipients for the Treatment of HCC based on Adjustable Preoperative Criteria with a Pre-determined, Center Specific, Five-year Patient Survival. .” Poster Presentation at the 15th Panhellenic Transplant Conference, Thassaloniki, Greece, December 2007

116. Vrochides D, Hassanain M, Barkun J, Tchervenkov J, Chaudhury P, Deschenes M, Wong P, Ghali P, Metrakos P. Biliary Tree Complications After OLTx are nto Prevented Either by Intraoperative Insertion of ERCP Stent or by Primary or Secondary Roux en Y anastomosis. Poster Presentation at the 15th Panhellenic Transplant Conference, Thassaloniki, Greece, December 2007


117. Vrochides D, Hassanain M, Barkun J, Tchervenkov J, Chaudhury P, Deschenes M, Wong P, Ghali P, Metrakos P. Persistant lymphopenia after anti-thymocyte globulin with decreased long term survival in liver transplant recipients. Oral Presentation at Canadian Transplant Congress Meeting, Mont Tremblant, QC, Feb 2008.

118. Vrochides D, Hassanain M, Metrakos P, Tchervenkov J, Chaudhury P, Cantarovich M, Paraskevas S. Prolonged lymphopenia after anti-thymocyte globulin induction is not associated with increased graft survival in pancreas transplant recipients. Poster Presentation at Canadian Transplant Congress Meeting, Mont Tremblant, QC, Feb 2008.

119. Vrochides D, Hassanain M, Barkun J, Tchervenkov J, Chaudhury P, Canatrovich M, Deschenes M, Wong P, Ghali P, Metrakos P. Prediction of postoperative mortality and long-term survival after liver transplantation, based on preoperative parameters. Poster Presentation at Canadian Transplant Congress Meeting, Mont Tremblant, QC, Feb 2008.

120. Vrochides D, Hassanain M, Metrakos P, Tchervenkov J, Chaudhury P, Cantarovich M, Paraskevas S. Persistant monocyte depletion does not improve graft survival after liver pancreas alone and kidney transplants. Poster Presentation at Canadian Transplant Congress Meeting, Mont Tremblant, QC, Feb 2008.

121. Vrochides D, Hassanain M, Barkun J, Tchervenkov J, Chaudhury P, Cantarovich M, Deschenes M, Wong P, Ghali P, Metrakos P. Selection of liver transplant recipients for the treatment of HCC based on adjustable preoperative criteria with a pre-determined, center specific, five-year patient survival target. Poster Presentation at Canadian Transplant Congress Meeting, Mont Tremblant, QC, Feb 2008.

122. Vrochides, Hassanain M, Metrakos P, Tchervenkov J, Chaudhury P, Cantarovich M, Paraskevas S. Allocation of non-ECD renal grafts to older patients results in loss of functioning graft-years secondary to recipients’ lower life expectancy. Highlighted Poster Presentation at Canadian Transplant Congress Meeting, Mont Tremblant, QC, Feb 2008

123. Vrochides D, Hassanain M, Barkun J, Tchervenkov J, Chaudhury P, Deschenes M, Wong P, Ghali P, Metrakos P. Baseline hepatic arterial Doppler increases patient but not graft survival in orthotopic liver transplantation. Poster Presentation at Canadian Transplant Congress Meeting, Mont Tremblant, QC, Feb 2008

124. Cantarovich M, Paraskevas S, Chaudhury P, Keith D, Baran D, Hassanian, Fernandez M, Mangel R, Lipman M, Metrakos P, Tchervenkov J, Ladouceur M. Estimated GFR after treatment of acute rejection: A surrogate marker for long-term graft survival after kidney transplantation. Poster Presentation at Canadian Transplant Congress Meeting, Mont Tremblant, QC, Feb 2008.

125. Boutros M, Neville A, Vrochides D, Paraskevas S, Chaudhury P, Metrakos P, Tchervenkov J, Fernandez M, Cantarovich M, Deschenes M, Ghali P, Wong P, Barkun J. A Randomized trial of intra-operative biliary stent at Orthotopic liver transplantation. Oral Presentation at Canadian Transplant Congress Meeting, Mont Tremblant, QC, Feb 2008.

126. Hassanain M, Lattermann R, Carvalho G, Karasek H, Molla H, Paglialunga S, Khankan A, Valenti D, Vrochides D, Chaudhury P, Schricker T, Metrakos P. Improving glycogen liver content improves post-operative liver function in patients undergoing major liver resections. Oral Presentation at American Hepato-Pancreato-Biliary Association Annual Meeting, Miami, FL, March 2008.

127. Chan G, Hassanian M, Meti N, Neville A, Chaudhury P, Metrakos P. The impact of aggressive treatment of chronic colorectal cancer liver metastases on quality of life. Oral Presentation at American Hepato-Pancreato-Biliary Association Annual Meeting, Miami, FL, March 2008.


128. Neville A, Hassanain M, Chan G, Meti N, Chaudhury P, Metrakos P. Staged liver resection for extensive bilobar colorectal liver metastases. Poster Presentation at American Hepato-Pancreato-Biliary Association Annual Meeting, Miami, FL, March 2008.

129. Hassanain M, Neville A, Chan G, Meti N, Chaudhury P, Metrakos P. Staged Liver resection for extensive bilobar colorectal liver metastases. Oral Presentation at Canadian Society of Surgical Oncology, Toronto, ON, April 2008 Canadian Journal of Surgery

130. Boutros M, Neville A, Vrochides D, Paraskevas S, Chaudhury P, Metrakos P, Tchervenkov J, Fernandez M, Cantarovich M, Deschenes M, Ghali P, Wong P, Barkun J. A Ramdomized trial of intra-operative biliary stent at Orthotopic liver transplantation. Oral Presentation at American Transplant Congress Meeting, Toronto, ON, May 2008.

131. Lattermann R, Hassanain M, Carvalho G, el-Shobary H, Metrakos P, Schricker T. Preservation of hepatic glycogen improves liver function after resection. Presented as an oral abstract at the Canadian Anesthesiologists' Society (CAS), Halifax, Nova Scotia, June 2008.

132. Hassanain M, Tchervenkov J, Arena G, Metrakos P, Chaudhury P, Cantarovich M, Fernandez M,Paraskevas S. Preliminary experience with universal use of pulsatile perfusion for deceased donor kidneys: An improvement in early graft function. Poster Presentation at the Canadian Society of Transplantation (CST) annual meeting, Banff, Canada, March 2009.

133. Hassanain M, Chaudhury P, Barkun J, Fernandez M, Paraskevas S, Tchervenkov J, Metrakos P. Postoperative Liver Transplant Function Score Can Predict Short and Long-Term Surgical OutcomesOral Presentation at the Canadian Society of Transplantation (CST) annual meeting, Banff, Canadam March 2009.

134. Cantarovich M, Tchervenkov J, Metrakos P, Deschênes M, Wong P, Ghali P, Chaudhury P, HassanainM, Arena G, Paraskevas S, Barkun J. Long-Term Immunosuppression with anti-CD25 Monoclonal Antibodies in Liver Transplant Patients. Oral Presentation at the Canadian Society of Transplantation (CST) annual meeting, Banff, Canadam March 2009.

135. Cantarovich M, Tchervenkov J, Barkun J, Deschênes M, Wong P, Ghali P, Chaudhury P, Hassanain M, Arena G, Fernandez M, Paraskevas S, Metrakos P. Early Changes in Kidney Function predict Long-Term Chronic Kidney Disease and Mortality in Patients Following Liver Transplantation. Oral Presentation at the Canadian Society of Transplantation (CST) annual meeting, Banff, Canadam March2009.

136. Burnier J, Wang N, Antecka E, Michel R, Hassanain M, Metrakos P, Burnier M, Gallinger S, Brodt P. Collagen IV expression levels are a critical determinant of liver metastasis. Poster presentation at the American Association for Cancer Research (AACR), Denver, USA, April 2009.

137. Hassanain M, Tchervenkov J, Barkun J, Paraskevas S, Chaudhury P, Metrakos P. Postoperative Liver Transplant Function Score Can Predict Short and Long-Term Surgical Outcomes. Poster Presentation at the American Transplant Society meeting, Banff, Alberta, Canada, March 2009

138. Hassanain M, Metrakos P, Boutros M, Barkun J, Fernandez M, Cantarovich M, Paraskevas S, Chaudhury P, Tchervenkov J. Predictors of Clinically Severe Hepatitis C Recurrence after Liver Transplantation. Poster Presentation at the American Transplant Society meeting, Banff, Alberta, Canada, March 2009


139. Chaudhury P,Hassanain M, Bouganim N, Kavan P, Metrakos P. Perioperative Bevacizumab Containing Chemotherapy for Colorectal Cancer Liver Metastasis. Oral Presentation at the American HepatoPamcreatoBiliary Association (AHPBA) meeting, Miami Beach, Florida, March 2009

140. Hassanain M, Metrakos P, Barkun J, Fernandez M, Chaudhury P, Tchervenkov J. Postoperative Liver Transplant Function Score Can Predict Long-term outcomes. Poster Presentation at the American HepatoPamcreatoBiliary Association (AHPBA) meeting, Miami Beach, Florida, March 2009

141. Tabariès S, Dong Z, Pépin F, Hallett M, Omerglu A, Hassanain M, Metrakos P, Siegel P M. Microenvironment-induced gene expression changes in breast cancer liver metastases. Oral Presentation at the American HepatoPamcreatoBiliary Association (AHPBA) meeting, Miami Beach, Florida, March 2009

142. Chaudhury P, Hassanain M, Nudo C, Bouteaud J, Cabrera T, Valenti D, Metrakos P. Combined sorafenib and Yttrium-90 radioembolization in the treatment of advanced HCC: preliminary results. Oral Presentation at the American HepatoPamcreatoBiliary Association (AHPBA) meeting, Miami Beach, Florida, March 2009

143. Bouganim N, Kavan P, Eid M-D, Batist G, Hassanain M, Metrakos P, Chaudhury P. Perioperative chemotherapy with bevacizumab (BV) for liver metastases (LM) in colorectal cancer (CRC): McGill University Pilot Study. Poster Presentation at the ESMO Conference: 11th World Congress on Gastrointestinal Cancer, Barcelona, Spain, June 2009

Published Abstracts

1. Deschenes M, Forbes C, Barkun J, Alpert E, Cantarovich M, Metrakos P, Fernandez M, Tchervenkov J. The use of older donor livers is associated with more severe preservation injury following liver transplantation. Gastroenterology. 1998 Apr;114(4):L0142

2. Tchervenkov JI, Metrakos P, Barkun J, Cantarovich M, Deschenes M, Alpert E, Tector AJ, Fridell JA, Aalamian Z. Rejection rate and cost of maintenance immunosuppression is reduced when using Tacrolimus compared to Neoral (R) based immunosuppression in liver transplant recipients. Hepatology. 1998 Oct;28(4):770

3. Tector AJ, Fridell JA, Greinke D, Salazar J, Metrakos P, Tchervenkov JI. Discordant hepatic xenotransplantation in recipients with liver failure: A window of opportunity for clinical trials? Hepatology. 1998 Oct;28(4):2346

4. Tector AJ, Fridell JA, Watanabe T, Metrakos P, Tchervenkov JI. Dog-to-pig hepatic xenotransplantation: A suitable large animal model for the pursuit of clinical pig-to-human liver transplants. Hepatology. 1998 Oct;28(4):783

5. Tector AJ, Fridell JA, Watanabe T, Greinke D, Salazar J, Stevenson W, Metrakos P, Tchervenkov JI. Hyperacute rejection of discordant liver xenografts is diminished in recipients with liver failure. Transplantation. 1999 Apr;67(7):516

6. Cantarovich M, Barkun J, Deschenes M, Metrakos P, Tchervenkov J. Improvement of renal dysfunction secondary to cyclosporine in long-term liver transplant patients receiving mycophenolate mofetil and very low dose Neoral. Transplantation. 2000 Apr;69(8):219

7. Di Carlo A, Tector AJ, Tan M, Fridell JA, Liu SQ, Soderland C, Barkun JS, Metrakos P, Tchervenkov JI. Comparison of cytokine profiles of endothelial activation in aortic and hepatic models of xenotransplantation. Transplantation. 2000 Apr;69(8):558


8. Deschenes M, Barkun J, Cantarovich H, Alpert E, Metrakos P, Tchervenkov J. Corticosteroid treatment of late acute cellular rejection is associated with worst recurrent hepatitis C virus hepatitis after liver transplantation than treatment of early-acute cellular rejection. Hepatology. 2000 Oct;32(4):397

9. Deschenes M, Cantarovich M, Barkun J, Metrakos P, Alpert E, Tchervenkov J. Oral budesonide in the prevention of graft rejection after liver transplantation. Hepatology. 2000 Oct;32(4):1755.

10. Di Carlo A, Tector AJ, Tan M, Liu S, Awwad M, Soderland C, Metrakos P, Tchervenkov JI. Complement inactivation or depletion of alpha-Gal XNA does not abrogate the transcription of early growth response factor-1 (Egr-1) in a model of pig-to-human liver xenotransplantation. Xenotransplantation. 2001 Aug;8:65.

11. Fridell JA, Mak A, Jensen G, Watanabe T, Metrakos P, Tchervenkov J, Teactor AJ. The dog-to-pig renal xenograft: a suitable model to study discordant pig-to-human xenografting. Xenotransplantation. 2001 Aug;8:338.

12. Tan M, Di Carlo A, Tchervenkov JI, Metrakos P. Glucocorticoids do not abrogate endothelial activation in response to islets in an in vitro dog-to-pig model of xenoislet transplantation. Xenotransplantation. 2001 Aug;8:619

13. Deschenes M, Barkun JS, Metrakos P, Tchervenkov JI. Recurrent portal hypertensive ascites following liver transplantation can be lymphocytic. Hepatology. 2001 Oct;34(4):1903

14. Tchervenkov JI, Deschenes M, Barkun JS, Metrakos P, Fernandez M, Alpert E, Di Carlo A. Liver transplantation (LT) for hepatitis C (HCV) under two immunossuppression protocols: Reduction in acute rejection is associated with worse survival. Hepatology. 2001 Oct;34(4):1876

15. Al Jabreen A, Deschenes M, Lilly L, Metrakos P. Successful liver transplantation using the liver of donors with cystic fibrosis. Hepatology. 2002 36(4):666A

16. Deschenes M, Dion B, Hoffman L, Metrakos P, Barkun J, Tchervenkov J. Nefazodone-induced liver failure within four weeks of institution of therapy. Hepatology. 2002 Oct;36(4):2057.

17. Deschenes M, Marotta P, Marleau D, Bain V, Yoshida E, Metrakos P. Liver transplantation for incidental cholangiocarcinoma - analysis of a Canadian multicenter experience. Hepatology. 2002 Oct;36(4):246

18. Cantarovich M, Barkun J, Deschenes M, Metrakos P, Alpert E, Wong P, Fernandez M, Tchervenkov J. Predictors of long-term renal function after liver transplantation. Liver Transplantation. 2003 Jun;9(6):301

19. Cantarovich M, Barkun J, Metrakos P, Deschenes M, Alpert E, Wong P, Fernandez M, Tchervenkov J. Renal dysfunction at 3-months post-liver transplant is not associated with poorer long-term renal function. Liver Transplantation. 2003 Jun;9(6):300

20. Cantarovich M, Barkun J, Metrakos P, Alpert E, Deschenes M, Paraskevas S, Fernandez M, Di Carlo A, Tchervenkov J. Anti-thymocyte globulin-induction allows delayed initiation of calcineurin inhibitors with a low rejection rate in liver transplant patients with post-operative renal dysfunction. Liver Transplantation. 2003 Jun;9(6):13.


21. Emadali A, Boutros T, Muscatelli-Groux B, Tzimas G, Jenna S, Rochon C, Nguyen DT, Caruso ME, Chevet E, Metrakos P. Characterization of the molecular machines involved in actin remodelling upon ischemia and reperfusion in human liver. Hepatology. 2003 Oct;38(4):651.

22. Warner MN, Metrakos P, Deschenes M, Barkun J, Tchervenkov J, Rivard GE. Orthotopic liver transplantation in a severe hemophilia A patient with factor VIII inhibitors. Blood. 2003 Nov;102(11):2963.

23. Tzimas G, Vali K, Deschenes M, Marcus V, Barkun J, Tchervenkov JI, Metrakos P. Liver Transplantation for Metastases from a Bile Duct Carcinoid. Official Journal of the International Hepato Pancreato Biliary Association 2004

24. Cantarovich M, Barkun J, Tchervenkov J, Paraskevas S, Schiff J, Mangel R, Deschenes M, Fontaine G, Coursol C, Metrakos P. Accuracy of cimetidine-corrected serum creatinine, creatinine clearance and calculated creatinine clearance to assess the glomerular filtration rate in long-term kidney-pancreas and liver transplant patients. American Journal of Transplantation. 2004;4:241

25. Han K, Tzimas G, Metrakos P, Hilzenrat N, Wong P, Deschenes M. Preoperative alpha-fetoprotein slope is predictive of hepatocellular carcinoma recurrence after liver transplantation. American Journal of Transplantation. 2004;4:1248

26. Wyse J, Poloni M, Wong P, Barkun J, Tchervenkov J, Metrakos P, Hilzenrat N, Deschenes M. Prevalence of sleep disturbance in liver transplantation recipients. Hepatology. 2004 Oct;40(4):550A-A

27. Tchervenkov J, Cantarovich M, Paraskevas S, Fernandez M, Baran D, Mangel R, Schiff J, Lipman M, Metrakos P. Cadaveric renal transplantation and expanded criteria donors: Should we reassess their use? American Journal of Transplantation. 2004;4:606

28. Rochon C., Liu S., Benay C., Chaudhury P., Seidah N., Metrakos P. The propretein convertase chaperone protein 7B2 is a new immunohistochemistry marker for primary and metastatic neuroendocrine tumors of the pancreas and GI tract. Journal of Gastrointestinal Surgery. 2005 9(4): 617.

29. Rochon C., Horton PJ., Fernandez M., Chaudhury P., Paraskevas S., Metrakos P. Severe aortic arteriosclerosis as observed by the surgeon during organ harvesting: An important marker to assess cadaver donors for renal transplantation. American Journal of Transplant. 2005 5(11): 174.

30. Martinie JB., Horton P., Chaudhury P., Znajda T., Barkun J., Metrakos P., Tchervenkov J. Liver transplantation for hepatocellular carcinoma outside Milan criteria: A single centre experience. Transplant International. 2005; 18(Suppl 1): 223.

31. Horton PJ., Znajda T., Martinie JB., Chaudhury P., Rochon C., Metrakos P. Novel approach for resection of hepatic lesions situated between the middle hepatic vein and vena cava, preserving the middle hepatic vein. Journal of Gastrointestinal Surgery. 2005 9(4): 553

32. Horton PJ., Tchervenkov J., Znajda T., Martinie JB., Chaudhury P., Rochon C., Barkun J., Metrakos P. Antithymocyte globulin induction therapy in hepatitis C positive liver transplant recipients. Journal of Gastrointestinal Surgery. 2005 9(4): 563.

33. Chaudhury P., Campisi G., Znajda T., Martinie JB., Rochon C., Horton PJ., Metrakos P. Outcomes of hepatic resection for colorectal metastasis following neoadjuvant chemotherapy. Journal of Gastrointestinal Surgery. 2005 9(4): 574.


34. Znajda T., Hayashi S., Horton PJ., Martinie JB., Chaudhury P., Jass J., Marcus V., Metrakos P. Histologic classification or remnants of hepatic metastases from colorectal cancer following chemotherapy. Journal of Gastrointestinal Surgery. 2005 9(4): 583.

35. Rochon C., Liu S., Benay C., Chaudhury P., Seidah N., Metrakos P. The propretein convertase chaperone protein 7B2 is a new immunohistochemistry marker for primary and metastatic neuroendocrine tumors of the pancreas and GI tract. Journal of Gastrointestinal Surgery. 2005 9(4): 617.

36. Rochon C, Horton PJ, Fernandez M, Chaudhury P, Paraskevas S, Metrakos P. Severe aortic arteriosclerosis as observed by the surgeon during organ harvesting: An important marker to assess cadaver donors for renal transplantation. American Journal of Transplant. 2005 5(11): 174.

37. Martinie JB, Horton P, Chaudhury P, Znajda T, Barkun J, Metrakos P, Tchervenkov J. Liver transplantation for hepatocellular carcinoma outside Milan criteria: A single centre experience. Transplant International. 2005; 18(Suppl 1): 223.

38. Cantarovich M, Horton P, Tchervenkov J, Barkun J, Deschenes M, Fernandez M, Metrakos P. Anti-thymocyte globulin induction and delayed introduction of calcineurin inhibitors improves survival and results in a low requirement for chronic dialysis in liver transplant recipients with post-operative renal dysfunction. American Journal of Transplantation. 2005 May;5:933

39. Cantarovich M, Paraskevas S, Keith D, Lipman M, Mangel R, Fontaine G, Metrakos P, Tchervenkov J. Optimal time points to assess the area-under-the-curve in long-term kidneytransplant patients on mycophenolate mofetil and either tacrolimus or cyclosporine microemulsion maintenance immunosuppression. American Journal of Transplantation. 2005 May;5:681.

40. Cantarovich M, Paraskevas S, Keith D, Lipman M, Mangel R, Fontaine G, Metrakos P, TchervenkovJ. Differences in pharmacokinetic profiles between long-term kidney/pancreas and non-diabetic kidney transplant patients on tacrolimus and mycophenolate mofetil. American Journal of Transplantation. 2005 May;5:687

41. Cantarovich M, Tchervenkov J, Paraskevas S, Keith D, Horton P, Baran D, Mangel R, Lipman M, Fernandez M, Metrakos P. Anti-thymocyte globulin induction and delayed introduction of calcineurin inhibitors results in excellent outcomes in renal transplant patients with delayed graft function. American Journal of Transplantation. 2005 May;5:123

42. Horton PJ, Barkun J, Cantarovich M, Rochon C, Fernandez M, Metrakos P, Tchervenkov J. Over 14 years experience with antithymocyte globulin (ATG) induction therapy in hepatitis C positive liver transplant recipients. American Journal of Transplantation. 2005 May;5:481.

43. Horton PJ, Barkun J, Rochon C, Fernandez M, Deschenes M, Metrakos P, Cantarovich M, Tchervenkov J. Twelve years experience preventing hepatitis-B recurrence with interferon and hepatitis-B immunoglobulin (HBIG) in liver transplant recipients. American Journal of Transplantation. 2005 May;5:94.

44. Horton PJ, Barkun J, Rochon C, Fernandez M, Metrakos P, Tchervenkov J. Predictors of graft outcome in hepatitis C positive liver transplant recipients. American Journal of Transplantation. 2005 May;5:84

45. Rochon C, Horton P, Fernandez M, Chaudhury P, Paraskevas S, Metrakos P. Severe aortic arteriosclerosis (AS) as observed by the surgeon during organ harvesting: An important marker to


assess cadaver donors grafts for renal transplantation. American Journal of Transplantation. 2005 May;5:72

46. Tchervenkov J, Barkun J, Horton P, Fernandez M, Cantarovich M, Deschenes M, Metrakos P. Early predictors of patient survival after liver transplantaion: Not all meld scores are created equal? American Journal of Transplantation. 2005 May;5:320

47. P Chaudhury, P Horton, P Metrakos, J Barkun, M Fernandez, P Ghali, M Deschenes, J Tchervenkov. Hepatitis C and the Milan Criteria. American Journal of Transplantation. 2006;6 Suppl. 2:974-975.

48. Tchervenkov J., Barkun J., Deschenes M., Gahali P., Fernandez M., Cantarovich M., Chaudhury P., Metrakos P. Viral Load Reduction Pre-Transplant for Hepatitis B in Liver Transplantation: Long term results of Interferon –Alpha 2B versus Lamivudine. Is it time for Re-Evaluation? American Journal of Transplantation. 2006;6 Suppl. 2:446.

49. Horton P., Martinie JB., Barkun J., Chaudhury P., Metrakos P. Hepatic Resection for Colorectal Metastases – A Canadian Perspective. HPB, 2006; 8(Suppl 1): 48.

50. Horton PJ, Chaudhury P, Rochon C, Metrakos P, Tchervenkov J. Should trials of liver xenotransplantation proceed in toxic fulminant hepatic failure? Xenotransplantation. 2006 Nov;13(6):483

51. Martinie JB., Horton P., Chaudhury P., Metrakos P. Inital Evaluation of PET/CT in patients with hepatic metastases from colorectal carcinoma.. HPB, 2006; 8(Suppl 1): 56.

52. Horton P., Chaudhury P., Martinie JB., Metrakos P. A new anatomical definition of respectability based on multiple staged hepatic resections leaving part of segment IV and caudate. HPB, 2006; 8(Suppl 1): 65.

53. Horton P., Chaudhury P., Martinie JB., Metrakos P. Liver Molding: A series of liver remnants derived from less than two segments. HPB, 2006; 8(Suppl 1): 79.

54. Chan G., Horton P., Barkun J., Martinie JB., Chaudhury P., Hill D., Marliss E., Metrakos P. CD34+ve Fibrous Sarcoma of liver associated with Hypoglycaemia. HPB, 2006; 8(Suppl 1): 79.

55. Larocque M, Lalonde R, Ghali P, Hilzenrat N, Barkun J, Metrakos P, Tchervenkof J, Deschenes M. Use of ethambutol and a quinolone in ppd positive patients with advanced cirrhosis before or after liver transplantation. Gastroenterology. 2006 Apr;130(4):A756-A

56. Chan G, Hassanain M, Chaudhury P, Znajda T, Metrakos P. The pathology of liver nodules after neoadjuvant chemotherapy is associated with outcomes for colorectal cancer metastases. HPB 2007; 9(Suppl 1): 99.

57. Cantarovich M, Tchervenkov J, Barkun J, Deschenes M, Paraskevas S, Wong P, Ghali P, Chauditury P, Vrochides D, Fernandez M, Metrakos P. Long-term renal function in liver transplant patients with post-operative renal dysfunction receiving anti-thymocyte globulin-induction and delaved calcineurin inhibitors. American Journal of Transplantation. 2007 May;7:1578.

58. Cantarovich M, Tchervenkov J, Giannetti N, Routy JP, Barkun J, Deschenes M, Ghali P, Wong P, Cecere R, Metrakos P. Long-term calcineurin inhibitor "retirement" with anti-CD25 monoclonal antibodies in non-renal transplant patients with chronic kidney disease. American Journal of Transplantation. 2007 May;7:1635


59. Keith DS, Paraskevas S, Cantarovich M, Tchervenkov J, Metrakos P. Does donor biopsy and degree of glomerulosclerosis have predictive value for subsequent graft and patient survival: An analysis of the UNOS database. American Journal of Transplantation. 2007 May;7:992.

60. Keith DS, Paraskevas S, Cantarovich M, Tchervenkov J, Metrakos P. Donor kidney biopsy and utilization of pairs of donor kidneys for transplantation: An analysis of the UNOS database. American Journal of Transplantation. 2007 May;7:1343.

61. Vrochides D, Metrakos P, Cantarovich M, Tchervenkov J, Keith D, Fernandez M, Paraskevas S. Prolonged lymphopenia after anti-thymocyte globulin induction is not associated with increased graft survival in renal transplant recipients. American Journal of Transplantation. 2007 May;7:1450

62. Ghali P, Deschenes M, Barkun J, Wong P, Hilzenrat N, Metrakos P, Tchervenkov J, Cantarovich M, Schwartzman K. Implications of preoperative pulmonary function testing for post liver-transplant outcomes. Hepatology. 2007 Oct;46(4):495A-A

63. Hassanain M, Lattermann R, Carvalho G, Karasek H, Molla H, Paglialunga S, Khankan A, Valenti D, Vrochides D, Chaudhury P, Schricker T, Metrakos P. ‘Improving glycogen liver content improves post-operative liver function in patients undergoing major liver resections’. HPB 2008; 10 (Suppl 2): 47 .

64. Chan G, Hassanain M, Meti N, Neville A, Chaudhury P, Metrakos P. ‘The impact of aggressive treatment of chronic colorectal cancer liver metastases on quality of life. HPB 2008; 10 (Suppl 2): 49.

65. Neville A, Hassanain M, Chan G, Meti N, Chaudhury P, Metrakos P. “Staged liver resection for extensive bilobar colorectal liver metastasis. HPB 2008; 10 (Suppl 2): 75.

66. Hassanain M, Neville A, Chan G, Meti N, Chaudhury P, Metrakos P. ‘Staged Liver resection for extensive bilobar colorectal liver metastases’. Canadian Journal of Surgery, Vol. 51, No. 3, June 2008

67. Boutros M, Cantarovich M, Tchervenkov J, Metrakos P, Chaudhury P, Paraskevas S, Deschenes M, Ghali P, Wong P, Fernandez M, Barkun JST. Early surrogate endpoints predict long-term outcomes in orthotopic liver transplantation. American Journal of Transplantation. 2008 May;8:375-.

68. Boutros M, Neville A, Vrochides D, Paraskevas S, Chaudhury P, Metrakos P, Tchervenkov J, Fernandez M, Cantarovich M, Deschenes M, Ghali P, Wong P, Barkun JS. A randomized trial of intra-operative biliary stent at orthotopic liver transplantation. American Journal of Transplantation. 2008 May;8:285-6.

69. Cantarovich M, Paraskevas S, Chaudhury P, Baran D, Keith D, Vrochides D, Hassanian M, Metrakos P, Tchervenkov J, Lipman M, Mangel R, Ladouceur M. Estimated GFR after treatment of acute rejection: A surrogate marker for long-term graft survival after kidney transplantation. American Journal of Transplantation. 2008 May;8:351-.

70. Tchervenkov J, Cantarovich M, Metrakos P, Paraskevas S, Keith D, Baran D, Fernandez M, Chaudary P. Delayed craft function has an equally bad impact on deceased donor renal graft survival in both standard criteria donors and expanded criteria donors. American Journal of Transplantation. 2008 May;8:531-.

71. Vrochides D, Hassanain M, Barkun J, Tchervenkov J, Chaudhury P, Cantarovich M, Deschenes M, Wong P, Ghali P, Metrakos P. Prediction of postoperative mortality and long-term survival after liver transplantation, based on preoperative parameters. American Journal of Transplantation. 2008 May;8:464-.


72. Vrochides D, Hassanain M, Barkun J, Tchervenkov J, Chaudhury P, Cantarovich M, Deschenes M, Wong P, Ghali P, Metrakos P. Selection of liver transplant recipients for the treatment of HCC based on adjustable preoperative criteria with a pre-determined, center specific, five-year patient survival target. American Journal of Transplantation. 2008 May;8:469-.

73. Vrochides D, Hassanain M, Metrakos P, Barkun J, Tchervenkov J, Chaudhury P, Cantarovich M, Deschcnes M, Wong P, Ghali P, Paraskevas S. Persistent lymphopenia after anti-thymocyte globulin induction is associated with decreased long term survival in liver transplant recipients. American Journal of Transplantation. 2008 May;8:543-.

74. Vrochides D, Hassanain M, Metrakos P, Tchervenkov J, Barkun J, Chaudhury P, Cantarovich M, Paraskevas S. Persistent monocyte depletion does not improve graft survival after liver, pancreas alone and kidney transplants. American Journal of Transplantation. 2008 May;8:426-

75. Vrochides D, Hassanain M, Metrakos P, Tchervenkov J, Chaudhury P, Cantarovich M, Paraskevas S. Allocation of non-ECD renal grafts to older patients results in loss of functioning graft-years secondary to recipients' lower life expectancy. American Journal of Transplantation. 2008 May;8:531-

76. Alcindor T, Trutschnigg B, Chaudhury P, Hassanain M, Metrakos P, Vigano A, editors. Is the platelet count a pronostic factor in pancreas cancer and cholangiocarcinoma? Annals of Oncology. 2008 Sep;19:185

77. Hassanain M, Tchervenkov JI, Cantarovich M, Metrakos P, Paraskevas S, Keith D, Baran D, Fernandez M, Mangel R, Chaudhury P. Recovery of graft function early posttransplant determines long-term graft survival in deceased donor renal transplants.Transplant Proc.2009 Jan-Feb;41(1):124-6.

78. Hassanain M, Tchervenkov J, Cantarovich M, Metrakos P, Paraskevas S, Keith D, Baran D, Fernandez M, Mangel R, Chaudhury P. Delayed graft function has an equally bad impact on deceased donor renal graft survival in both standard criteria donors and expanded criteria donors. Transplant Proc. 2009 Jan-Feb;41(1):133-4.

Publications

1. P. Metrakos, S.J. Qi, D. Agapitos, L. Rosenberg. Isolation of Hamster Islets by Intraductal Collagenase infusion and Bovine Serum Albumin Density Gradient Purification. Transplant Proceedings 1992: 6; 2830-32.

2. L. Rosenberg, P. Metrakos, S.J. Qi, D. R. Rajotte. Trophic Stimulation of Adult Human Islets in - vitro. Transplant Proceedings 1992: 6; 3012-13

3. P. Metrakos, L. Hornby, L. Rosenberg. Cyclosporine and Islet Mass - Implications for Transplantation. J. Surgical Research: 54(4), 375-380, 1993.

4. P. Metrakos, S. Yaun, D. Agapitos, L. Rosenberg. Pancreatic Intercellular Communication -Implications For Islet Cell Transplantation. Surgery, Vol. 114, No. 2 (Aug) 1993: 423-428

5. P. Metrakos, S.Y. Yuan, D. Agapitos, L. Rosenberg. Paracrine signaling (duct-islet) in the pancreas and maintenance of islet cell mass-potential implications for islet transplantation. Transplant Proc. 1994 Apr; 26(2):637-8.

6. N. Tchervenivanov, P. Metrakos, L. Rosenberg. Submucosal Transplantation of Pancreatic Islets. Transplant Proc. 1994 Apr; 26(2):680-1.


7. L. Hornby, P. Metrakos, L. Rosenberg. Cyclosporine: A Blockade of the Induction of Ornithine Decarboxlase Activity as a Cause of Failure of Islet Cell Proliferation. Clin. Invest. Med. Vol. 17: 6 (Dec)1994: 563-569

8. N. Tchervenivanov, P. Metrakos, S. Yaun, L. Rosenberg. Metabolic Evaluation of Islets Transplanted into the Submucosal Space. Transplant Proc. Dec; 26(6):3302-3.

9. P. Metrakos, S.Yaun, S.J. Qi, L. Rosenberg. Collagen Gel Matrix Promotes Islet Cell Proliferation. Transplant Proc. 1994 Dec; 26(6): 3349-50.

10. Yuan S, Metrakos P, Duguid WP, Rosenberg L. Isolation and Culture of Intralobular Ductules from the Hamster Pancreas. In Vitro Cellular & Developmental Biology-Animal. 1995 Feb;31(2):77-80.

11. Marelli D, Tchervenkov CI, Metrakos P, Barayan S, Hasel R, Brown R. Deep hypothermic circulatory arrest for blunt retrohepatic venous injury: a case report. J. of Trauma 1995 Apr; 38(41): 609-611.

12. P. Metrakos, A.I. Lazerovts. Transplantation: Overcoming Long-term Rejection. Practical Allergy & Immunology 1995 May; 10(3): 99-107.

13. Fryer JP, Fortier MV, Metrakos P, Verran DJ, Asfar SK, Pelz DM, Wall WJ, Grant DR, Ghent CN. Central pontine myelinolysis and cyclosporine neurotoxicity following liver transplantation. Transplantation 1996 Feb 27; 61(4):658-661.

14. Asfar S, Metrakos P, Fryer J, Verran D, Ghent CN, Grant D, Bloch M Burns, Wall W. An analysis of late deaths after liver transplantation. Transplantation 1996 May 15; 61(9): 1377-1381.

15. Kakugawa Y, Paraskevas S, Metrakos P, Giaid A, Qi SJ, Duguid WP, Rosenberg L. Alterations in pancreatic microcirculation and expression of endothelin-1 in a model of chronic pancreatitis. Pancreas. 1996 Jul;13(1):89-95.

16. Fryer J, Grant D, Jiang J, Metrakos P, Ozcay N, Ford C, Garcia B, Behme R, Zhong R. Influence of macrophage depletion on bacterial translocation and rejection in small bowel transplantation. Transplantation. 1996 Sep 15;62(5) :553-559.

17. Fryer JP, Jiang J, Zhong R, Metrakos P, Garcia B, Behme R, Grant D. Influence of macrophage depletion on bacterial translocation and rejection in small bowel Transplantation. Transplantation. 1996 Sep 15; 62(5): 553-559.

18. Tchervenkov JI, Tector AJ, Barkun J, Sherker A, Forbes CD, Elias N, Cantarovich M, Cleland P, Metrakos P, Meakins JL. Recurrence-Free Long-Term Survival After Liver Transplantation for Hepatitis B Using Interferon-Alpha Pretransplant and Hepatitis B Immune Globulin Posttransplant. Annals of Surgery. Sept 1997, 226(3): 356-368.

19. Tector AJ, Fridell JA, Watanabe T, Forbes RDC, Salazar J, Grienke D, Nuera SP, Metrakos P, Giaid A, Tchervenkov JI. Pulmonary injury in recipients of discordant hepatic and renal xenografts in the dog-to-pig model. Xenotransplantation. 1998 Feb;5(1):44-9

20. Cantarovich M, Fridell J, Barkun J, Metrakos P, Besner JG, Deschenes M, Alpert E, Aalamian Z, Tchervenkov JI. Optimal time points for the prediction of the area-under-the-curve in liver transplant patients receiving tacrolimus. Transplantation Proceedings. 1998 Jun;30(4):1460-1.


21. Cantarovich M, Barkun J, Besner JG, Metrakos P, Alpert E, Deschenes M, Aalamian Z, Tchervenkov JI. Cyclosporine peak levels provide a better correlation with the area-under-the-curve than trough levels in liver transplant patients treated with neoral. Transplantation Proceedings. 1998 Jun;30(4):1462-3

22. West MS, Stevens RB, Metrakos P, Foshager MC, Jessurun J, Sutherland DER, Gruessner RWG. Renal pedicle torsion after simultaneous kidney-pancreas transplantation. Journal of the American College of Surgeons. 1998 Jul;187(1):80-7

23. West M, Gruessner AC, Metrakos P, Sutherland DER, Gruessner RWG. Conversion from bladder to enteric drainage after pancreaticoduodenal transplantations. Surgery. 1998 Nov;124(5):883-93

24. Deschenes M, Barkun J, Cantarovich M, Alpert E, Metrakos P, Fernandez M, Tchervenkov J. Liver transplantation in patients over 65 years of age: Mortality, morbidity and quality of life. Hepatology. 1998 Oct;28(4):247

25. Cantarovich M, Barkun JS, Tchervenkov JI, Besner JG, Aspeslet L, Metrakos P. Comparison of neoral dose monitoring with cyclosporine trough levels versus 2-hr postdose levels in stable liver transplant patients. Transplantation. 1998 Dec;66(12):1621-7.

26. Kumar U, Sasi S, Suresh A, Patel M, Thangaraju P, Metrakos P, Patel SC, Patel YC. Subtype selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: A quantitative double-label immunohistochemical analysis. Diabetes 1999 Jan;48(1) :77-85.

27. Leushner JR, Wu K, Metrakos P, et al. Temporal and Quantitative Analysis of Chimerism in Liver and Kidney Transplant Patients: An Enhanced Fluorescence Detection System Allows for More Sensitive Quantitative Detection. Mol Diagn. 2(3): 187-195.

28. Deschenes M, Forbes C, Tchervenkov J, Barkun J, Metrakos P, Tector J, Alpert E. Use of older donor livers is associated with more extensive ischemic damage on intraoperative biopsies during liver transplantation. Liver Transplantation and Surgery. 1999 Sep;5(5):357-61

29. Tector AJ, Fridell JA, Watanabe T, Forbes C, Salazar J, Grienke D, Nuera S, Metrakos P, Giaid A, Tchervenkov JI. Experimental discordant hepatic xenotransplantation in the recipient with liver failure: Implications for clinical bridging trials. Journal of American College of Surgeons. 2000 Jul; 191(1) :54-64.

30. Baldry C, Backman SB, Metrakos P, Tchervenkov JI, Barkun J, Moore A. Liver Transplantation in a Jehovah’s Witness with Ankylosing Spondylitis. Canadian Journal of Anesthesia. 2000 Jul; 47(7) :642-646.

31. Morin N, Lamoureux E, Lipman M, Tector J, Tchervenkov JI, Metrakos P. Donor-Specific Portal Transfusion Augments Microchimerism in a porcine model of small bowel transplantation. Transplant Proc. 2000 Sep; 32(6) :1290-1.

32. Tector AJ, Berho M, Fridell JA, Di Carlo A, Liu S, Soderland C, Brkun JS, Metrakos P, Tchervenkov JI. Rejection of pig liver xenografts in patients with liver failure: implications for xenotransplantation. Liver Transpl. 2001 Feb; 7(2) :82-9.

33. Di Carlo A, Tector AJ, Liu S, Tan M, Barkun JS, Soderland C, Metrakos P, Tchervenkov JI. Activation of porcine hepatic microvascular sinusoidal endothelial cells in pig-to-human liver xenotransplantation. Transplant Proc. 2001 Feb-Mar; 33(1-2) :7559-61


34. Tchervenkov JI, Metrakos P, Deschenes M, Alpert E, Tector AJ, Cantarovich M, Barkun JS. Decreasing viral load pretransplant and passive immunoprophylaxis with hepatitis B immunogloulin posttransplant prevents hepatitis B virus recurrence after liver transplantation: an 8-year single-center experience. Transplant Proc. 2001 Feb-Mar; 33(1-2) : 1514-5.

35. Khatib AM, Siegfried G, Prat A, Luis J, Chrétien M, Metrakos P, Seidah NG. Inhibition of Proprotein Convertases Is Associated with Loss of Growth and Tumorigenicity of HT-29 Human Colon Carcinoma Cells. Importance of insulin-like growth factor-1 (igf-1) receptor processing in igf-1-mediated functions.J. Biol. Chem. 2001 Aug; 276 :30686-30693.

36. Tan M, Di Carlo A, Stein L, Tchervenkov JI, Metrakos P. Pseudoaneurysm of the superior mesenteric artery after pancreas transplantation treated by endovascular stenting: a case report and literature review. Transplantation. 2001 Jul 27; 72(2) :336-8.

37. Tan M, Di Carlo A, Robinson P, Tchervenkov JI, Barkun JS, Metrakos P. Successful outcome following transplantation of a donor liver with focal nodular hyperplasia. Liver Transplantation. 2001 Jul; 7(7) :652-5.

38. Deschenes M, Michel RP, Alpert E, Barkun JS, Metrakos P, Tchervenkov JI. Elevation of ca-125 level is due to abdominal distension in liver transplantation candidates. Transplantation. 2001 Nov 15; 72(9) :1519-22.

39. Tan, M, Di Carlo A, Tchervenkov JI, Metrakos P. Hepatic sinusoidal endothelium upregulates IL-1, IFN-, and iNOS in response to discordant xenogeneic islets in an in vitro model of xenoislet transplantation. Journal of Surgical Research. 2002 Feb;102(2) : 229-36

40. Tector AJ, Fridell JA, Elias N, Watanabe T, Salazar J, Greinke D, Metrakos P, Tchervenkov JI. Aberrations in hemostasis and coagulation in untreated discordant hepatic xenotransplantation: studies in the dog-to-pig model. Liver Transpl. 2002 Feb;8(2) : 153-9

41. Cantarovich M, Metrakos P, Giannetti N, Cecere R, Barkun J, Tchervenkov JI. Anti-CD25 monoclonal antibody coverage allows for calcineurin inhibitor “holiday” in solid organ transplant patients with acute renal dysfunction. Transplantation. 2002 Apr 15;73(7) : 1169-72

42. Tzimas GN, Barkun JS, Metrakos P, Tchervenkov JI. Aberrant right hepatic artery; A mockery. Liver Transpl. 2002 Apr;8(4) : 411.

43. Khatib AM, Siegfried G, Chretien M, Metrakos P, Seidah NG. Proprotein convertases in tumor progression and malignancy - Novel targets in cancer therapy. American Journal of Pathology. 2002 Jun;160(6):1921-35

44. Tan M, Cantarovich M, Mangel R, Paraskevas S, Fortier M, Metrakos P. Low dose Thymoglobulin®, Tacrolimus, and Mofetil Mycophenolate results in excellent solitary pancreas transplantation outcomes. Clinical Transplantation Volume 16, Issue 6, Page 414, Dec 2002

45. Chan G, Tchervenkov J, Cantarovich M, Alpert E, Deschenes M, Ergina P, Metrakos P, Barkun J. Veno-Atrial Bypass for the Operative Treatment of Septic Gas Gangrene Secondary to Delayed Hepatic Artery Thrombosis. American Journal of Transplantation June 2003; 3: 760-763

46. Aljebreen AR, Deschenes M, Lilly L, Metrakos P. Successful liver transplantation using liver of donors with cystic fibrosis. Hepatology. 2003 Oct;38(4):1059; discussion 1059-60


47. Barkun JS, Tzimas G, Cantarovich M, Metrakos P, Deschenes M, Alpert E, Paraskevas S, Tchervenkov JI. Do biliary endoprostheses decrease biliary complications after liver transplantation?, Transplantation Proceedings, 35(7): 2435-2437, November 2003

48. Tzimas GN, Hayati H, Tchervenkov JI, Metrakos PP. Ureteral implantation technique and urologic complications in adult kidney transplantation. Transplant Proc. 2003 Nov 35(7):2420-2

49. Feldman LS, Anidjar M, Metrakos P, Standbridge D, Fried GM, Carli F. Optimization of cardiac preload during laparoscopic donor nephrectomy: a preliminary study of central venous pressure versus esophageal Doppler monitoring. Surg Endosc. 2004 Mar;18(3):412-6.

50. Tzimas GN, Afshar A, Emadali E, Vali H, Metrakos PP. Correlation of Cell Necrosis and Tissue Calcification With Ischemia/Reperfusion Injury After Liver Transplantation. Transplantation Proceedings. 2004 Jul-Aug;36(6) :1766-8

51. Morin N, Metrakos P, Berman K, Shen Y, Lipman ML. Quantification of donor microchimerism in sex-mismatched porcine allotransplantation by competitive PCR. Biotechniques. 2004 Jul ;37(1) :74-6, 78, 80-1

52. Tzimas GN, Deschenes M, Barkun JS, Wong P, Tchervenkov JI, Hayati HE, Metrakos P. Leukoreduction and acute rejection in liver transplantation: an international analysis. Transplant Proc. 2004 Jul-Aug;36(6):1760-2.

53. Tchervenkov JI, Tzimas GN, Cantarovich M, Barkun JS, Metrakos P. The impact of thymoglobulin on renal function and calcineurin inhibitor initiation in recipients of orthotoptic liver transplantation: a retrospective analysis of 298 consecutive patients. Transplant Proc. 2004 Jul-Aug;36(6):1747-52.

54. Tzimas GN, Afshar M, Chevet E, Emadali A, Vali H, Metrakos PP. Graft calcifications and dysfunction following liver transplantation. BMC Surgery. 2004 Sep 03 ;4(1) :9

55. Shan WL, Barkun J, Metrakos P, Tchervenkov J, Backman SB. Blood product use during orthotopic liver transplantation. Can J Anaesth. 2004 Dec;51(10) :1045-6.

56. Rochon C, Metrakos P, Tchervenkov JI, Fernandez M, Paraskevas S, Barkun J, Deschesnes M, Stein L. Endoscopic stenting as first-line treatment in duct of Lushka leaks after choledochocystic anastomosis in two cases of liver transplantation. Transplantation. 2005 Mar 27;79(6):740-1

57. Mardigyan V, Tchervenkov J, Metrakos P, Barkun J, Deschenes M, Cantarovich, M. Best Single Time Points as Surrogates to the Tacrolimus and Mycophenolic Acid Area Under the Curve in Adult Liver Transplant Patients Beyond 12 months of Transplantation. Clinical Therapeutics 27(4) 463-469, April 2005.

58. Feifer AH, Fong BC, Feldman L, Fried G, Stein LA, Metrakos P, Bergman S, Anidjar M. Preoperative evaluation of laparoscopic living renal donors with computerized tomography and its effects on donor morbidity and graft function. Can J Urol. 2005 Jun;12(3):2713-21.

59. Emadali A, Nguyên DT, Rochon C, Tzimas GN, Metrakos P, Chevet E. Distinct endoplasmic reticulum stress responses are triggered during human liver transplantation. J Pathol. 2005 Sep;207(1):111-8.

60. Horton PJ, Tchervenkov J, Barkun JS, Rochon C, Chaudhury PK, Znajda TL, Martinie JB, Metrakos P. Antithymocyte globulin induction therapy in hepatitis C-positive liver transplant recipients. Journal of Gastrointestinal Surgery. 2005 Sep-Oct;9(7):896-902


61. Horton P, Tchervenkov J, Barkun JS, Rochon C, Chaudhury PK, Znajda TL, Martinie JB, Metrakos P. Antithymocyte globulin induction therapy in hepatitis C-positive liver transplant recipients. Journal of Gastrointestinal Surgery. 2005 9(7):896-902.

62. Ghali P, Marotta PJ, Yoshida EM, Bain VG, Marleau D, Peltekian K, Metrakos P. Liver Transplantation for incidental cholangiocarcinoma: analysis of the Canadian experience. Liver Transpl. 2005 Nov;11(11):1412-6

63. Tzimas G, Chevet E, Jenna S, Nguyen DT, Khatib AM, Marcus V, Zhang Y, Chretien M, Seidah N, Metrakos P. Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases. BMC Cancer. 2005 Nov 17;5:149

64. Horton P, Chaudhury P, Znajda T, Martinie J, Rochon C, Tzimas G, Metrakos P. Novel Two-Step Resection for Lesions Between the Middle Hepatic Vein and Vena Cava Which Allows the Middle Hepatic Vein to Be Preserved. J. Gastrointestinal Surgery. 2006 Jan;10(1):69-76

65. Schiff J, Paraskevas S, Keith D, Tchervenkov J, Metrakos P, Cantarovich M. Prediction of the glomerular filtration rate using equations in kidney-pancreas transplant patients receiving cimetidine. Transplantation. 2006 Feb 15;81(3):469-72.

66. Znajda TL, Hayashi S, Horton PJ, Martinie JB, Chaudhury P, Marcus VA, Jass JR, Metrakos P. Postchemotherapy characteristics of hepatic colorectal metastases: Remnants of uncertain malignant potential. Journal of Gastrointestinal Surgery. 2006 Apr;10(4):483-9

67. Emadali A, Muscatelli-Groux B, Delom F, Jenna S, Boismenu D, Sacks DB, Metrakos PP, Chevet E. Proteomic analysis of ischemia-reperfusion injury upon human liver transplantation reveals the protective role of IQGAP1. Mol Cell Proteomics. 2006 Jul;5(7):1300-13.

68. Znajda T., Hayashi S., Horton PJ., Martinie JB., Chaudhury P., Marcus VA., Jass JR., Metrakos P. Post Chemotherapy Characteristics of Hepatic Colorectal Metastases: Remnants of uncertain Malignant Potential (RUMP). Journal of Gastrointestinal Surgery. 2006 10(4): 483-89.

69. Horton P, Chaudhury P, Rochon C, Metrakos P, Tchervenkov J. Should Trial of Liver Xenotransplantation proceed in Toxic Fulminant Hepatic Failure. Xenotransplantation. 2006 13(6): 483.

70. Emadali A, Metrakos P, Kalantari F, Boutros T, Boismenu D, Chevet E. Proteomic analysis of tyrosine phosphorylation during human liver transplantation. Proteome Sci. 2007 Jan 2;5:1.

71. Han K, Tzimas GN, Barkun JS, Metrakos P, Tchervenkov JL, Hilzenrat N, Wong P, Deschênes M.Preoperative alpha-fetoprotein slope is predictive of hepatocellular carcinoma recurrence after liver transplantation. Can J Gastroenterol. 2007 Jan;21(1):39 45.

72. Bernier PL, Grenon M, Ergina P, Schricker T, Chaudhury P, Metrakos P, Lachapelle K. Combined Simultaneous Heart and Liver Transplantation with Complete Cardiopulmonary Bypass Support. Ann Thorac Surg. 2007 83:1544-1545.

73. Bergman S, Di Carlo A, Chaudhury P, Blum C, Nahal A, Metrakos P. Recurrent pyogenic cholangitis in a white woman. Can J Surg. 2007 Oct 10;50(5):E9-10.

74. Chan G, Horton PJ, Thyssen S, Lamarche M, Nahal A, Hill DJ, Marliss EB, Metrakos P. Malignant transformation of a solitary fibrous tumor of the liver and intractable hypoglycemia. J Hepatobiliary Pancreat Surg. 2007;14(6):595-9. Epub 2007 Nov 30.


75. Tzimas GN, Vali K, Deschênes M, Marcus VA, Barkun JS, Tchervenkov JI, Metrakos PP.Liver transplantation for metastases from a bile duct carcinoid. HPB (Oxford). 2006;8(1):67-8.

76. Bergman S, Feldman LS, Anidjar M, Demyttenaere SV, Carli F, Metrakos P, Tchervenkov J, Paraskevas S, Fried GM. "First, do no harm": monitoring outcomes during the transition from open to laparoscopic live donor nephrectomy in a Canadian centre. Can J Surg. 2008 Apr;51(2):103-10.

77. Hassanain M, Schricker T, Metrakos P, Carvalho G, Vrochides D, Lattermann R. Hepatic protection by perioperative metabolic support? Nutrition. 2008 Nov-Dec;24(11-12):1217-9. Epub 2008 Jun 30.

78. Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Häussinger D, Giannaris T, Shan M, Moscovici M, Voliotis D, Bruix J; SHARP Investigators Study Group. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008 Jul 24;359(4):378-90.

79. Boutros T, Chevet R, Metrakos P. Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death and cancer. Pharmacological Review. 2008 Sep;60(3):261-310.

80. Hassanain M, Schricker T, Metrakos P, Carvalho G, Vrochides D, Lattermann R. Hepatic protection by perioperative metabolic support? Nutrition. 2008 Nov-Dec;24(11-12):1217-9

81. Boutros T, Nantel A, Emadali A, Tzimas G, Conzen S, Chevet E, Metrakos P. The map kinase phosphatase-1 mkp-1/dusp1 is a regulator of human liver response to transplantation. Am J Transplant. 2008 Dec;8(12):2558-68.

82. Hassanain M, Tchervenkov J, Cantarovich M, Metrakos P, Paraskevas S, Keith D, Baran D, Fernandez M, Mangel R, Chaudhury P.Delayed graft function has an equally bad impact on deceased donor renal graft survival in both standard criteria donors and expanded criteria donors. Transplant Proc. 2009 Jan-Feb;41(1):133-4.

83. Hassanain M, Tchervenkov JI, Cantarovich M, Metrakos P, Paraskevas S, Keith D, Baran D, Fernandez M, Mangel R, Chaudhury P. Recovery of graft function early posttransplant determines long-term graft survival in deceased donor renal transplants.Transplant Proc. 2009 Jan-Feb;41(1):124-6.

Book Chapters

1. P. Metrakos and J.L. Meakins. Shock: Causes and Management of Circulatory Collapse. In: Essentials of Surgery, Second Edition. Edited by David C. Sabiston and H. Kim Lyerly. W.B. Saunders Company, 1994, p 24- 35.

2. Lapointe R, Metrakos P, Chaudhury P, Poirier E. New Horizons: Resectability in colorectal liver metastases (CRLM). Clinical Companion Series. Elsevier Health Communications. 2008

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