Engineered 3D Vascular Networks: Enabling technology for Vital Organ Engineering

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Engineered 3D Vascular Networks: Enabling technology for Vital Organ Engineering Complex liver microvasculat ure Construct synthetic vascular networks with thermally reversible polymers and microfluidics Aim 1 Aim 2 Cross- section Hepatocytes Engineer ed vascular networks Top Assemble alternating vascular and hepatocyte layers towards 3D synthetic vascularized liver construct Vascular-mimetic microfluidic channel Mold thermally reversible polymer containing endothelial cells culture Cross - secti on End goal: formed endothelial tube 200μm (Mary Beth Wilson, Dowd Fellowship 2010)

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Engineered 3D Vascular Networks: Enabling technology for Vital Organ Engineering. Aim 1. Construct synthetic vascular networks with thermally reversible polymers and microfluidics. End goal: formed endothelial tube. Top . Vascular-mimetic microfluidic channel . - PowerPoint PPT Presentation

Transcript of Engineered 3D Vascular Networks: Enabling technology for Vital Organ Engineering

Page 1: Engineered 3D Vascular Networks: Enabling technology for Vital Organ Engineering

Engineered 3D Vascular Networks: Enabling technology for Vital Organ Engineering

Complex liver microvasculature

Construct synthetic vascular networks with thermally reversible polymers and microfluidics

Aim 1

Aim 2

Cross-sectionHepatocytes

Engineeredvascular networks

Top

Assemble alternating vascular and hepatocyte layers towards 3D synthetic vascularized liver construct

Vascular-mimetic microfluidic channel

Mold thermally reversible polymer containing

endothelial cells cultureCross-section

End goal: formed endothelial tube

200μm

(Mary Beth Wilson, Dowd Fellowship 2010)

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