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CCUURRRRIICCUULLUUMM VVIITTAAEE Name: Paul Michel Georges Vanhoutte Birthdate: November 26, 1940, Merelbeke (Oost-Vlaanderen, Belgium) Nationality: American, French Residency: Hong Kong, China Languages: English, French, Dutch, (German) UNIVERSITY DEGREES: Candidate in Natural and Medical Sciences (equivalent to B.S.) State University of Gent, Belgium, magna

cum laude, 1961. Doctor in Medicine, Surgery and Obstetrics (equivalent to M.D.) State University of Gent, Belgium, magna

cum laude, 1965. Licentiate in Physical Education (equivalent to M.S.) State University of Gent, Belgium, cum laude, 1970. Aggregation in Higher Education (equivalent to Ph.D.) University of Antwerp, Belgium, 1973. HONORARY DEGREES: Doctor Honoris Causa, State University of Gent, Belgium, 2001. Doctor Honoris Causa, University of Zürich, Switzerland, 2003. Doctor Honoris Causa, University of Antwerp, Belgium, 2003. Doctor Honoris Causa, University of Montreal, Canada, 2003. Doctor Honoris Causa, Royal Melbourne Institute of Technology University, 2005. Doctor Honoris Causa, Université Louis Pasteur, Strasbourg, France, 2006 Doctor Honoris Causa, Gr. T. Popa University of Medicine and Pharmacy, Iasi, Romania, 2009 Doctor Honoris Causa, Monash University, Australia, 2012

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GRADUATE AND POSTGRADUATE SCIENTIFIC TRAINING: Student-Assistant, Laboratory for Normal and Pathological Physiology (Directors: Dr. J. J.

Bouckaert and Dr. I. Leusen), State University of Gent, Belgium, 1961-1965. Research Assistant, Laboratory for Normal and Pathological Physiology (Directors: Dr. J. J. Bouckaert and

Dr. I. Leusen), State University of Gent, Belgium, 1965-1968. Research Assistant, Department of Physiology and Biophysics (Chairman: Dr. J. T. Shepherd), Mayo

Clinic and Mayo Foundation, Rochester, Minnesota,1968-1969. SCIENTIFIC CAREER : First Assistant, Laboratory for Normal and Pathological Physiology (Director: Dr. I. Leusen), State

University of Gent, Belgium, 1969-1971. Research Associate, Department of Physiology and Biophysics (Chairman: Dr. J.T. Shepherd), Mayo

Clinic and Mayo Foundation, Rochester, Minnesota, 1972-1973. Head, Laboratory of Pathophysiology, Department of Internal Medicine, Universitaire Instelling

Antwerpen, University of Antwerp, Wilrijk, Belgium, 1973-1975. Head, Laboratory of Pharmacology, Division of Internal Medicine, Department of Medicine, Universitaire

Instelling Antwerpen, University of Antwerp, Wilrijk, Belgium, 1975-1981. Consultant, Department of Physiology and Biophysics, and Department of Cardiovascular Medicine, Mayo

Clinic, Rochester, Minnesota, 1981-1989. Director, Center for Experimental Therapeutics, Department of Medicine, Baylor College of Medicine,

Houston, Texas, 1989-1995. Vice-President Research and Development, Institut de Recherches Internationales Servier, Courbevoie,

France, 1992-2002. Director, BioPharmaceutical Development Centre, University of Hong Kong, Hong Kong, China, 2003-

present. Head, Department of Pharmacology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong

Kong, China, 2006-present. ACADEMIC CAREER, HONORARY AND VISITING PROFESSORSHIPS : Lecturer in Pathophysiology, Faculty of Medicine, National University of Rwanda, Butare, Rwanda, 1967. Assistant Professor of Physiology, Mayo Medical School, University of Minnesota, Rochester, Minnesota,

1972-1973.

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Assistant Lecturer of Physiopathology, Faculty of Medicine, University of Antwerp, Wilrijk, Belgium, 1973.

Lecturer in Physiology and Pathophysiology, Faculty of Medicine, University of Antwerp, Wilrijk,

Belgium, 1974. Lecturer in Physiology, Premedical School, University of Antwerp, Antwerpen, Belgium, 1974-1977. Visiting Lecturer, Mayo Medical School, Rochester, Minnesota, 1974-1975. Visiting Professor, Polish Academy of Sciences, Warsaw, Poland, 1979. Full Professor of Pharmacology and Physiology, Faculty of Medicine, University of Antwerp, Wilrijk,

Belgium, 1975-1981. Pfizer Visiting Professors Program in Cardiovascular Medicine, New York Medical College, February 24,

1992. Visiting Faculty Member, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, 1979-1980. Professor of Physiology and Pharmacology, Mayo Medical School and Mayo Graduate School of

Medicine, Rochester, Minnesota, 1981-1989. Professor of Medicine, Pharmacology and Physiology, Department of Medicine, Baylor College of

Medicine, Houston, Texas, 1989-1995. Visiting Professorship of the Royal College of Physicians and Surgeons of Canada, Winnipeg, Canada,

October 30, 1989. Wellcome Visiting Professorship in the Basic Medical Sciences, Tulane University Medical Center,

February 12-16, 1990. Fouad A. Bashour Visiting Professorship, The University of Texas, Southwestern Medical Center, Dallas,

Texas, October 17, 1988. Honorary Professor, Peking Union Medical College, Beijing, China, 1997-present. Honorary Professor, Institute of Materia Medica,Beijing, China, 1998-present. Honorary Professor, Shanghai Institute of Materia Medica, Shanghai, China, 1998-present. Honorary Professor, Ocean University of Qingdao, Qingdao, China, 2002-present. Honorary Professor, Second Military Medical University, Shanghai, China, 2002-present. Visiting Professor, Nanjing Medical University, Nanjing, China, 1998-present. Visiting Professor, Beijing Medical University, Beijing, China, China, 1998-present. Visiting Professor, University of South Denmark, Odense, Denmark, 2003-present.

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Visiting Professor, University of Zürich, Zürich, Switzerland, 2003-present. Distinguished Visiting Professor, University of Hong Kong, Hong Kong, China, 2003-present. Visiting Professor, Université Louis Pasteur, Strasbourg, France, 2006-2008. Honorary Professor, Department of Anaesthesiology, the University of Hong Kong, 2008-2009. Visiting Professor, Chonbuk National University, Jeonju, Korea, 2009-present DISTINCTIONS AND NAMED LECTURES: First Laureate, Interuniversity Competition of the Belgian Government (Universitaire Wedstrijd); Group:

Physiological Sciences, Brussels, Belgium, 1963-1964. Special prize, State University of Gent, Belgium, 1965. First Laureate, Travel Grant Competition of the Belgian Government (Wedstrijd voor Reisbeurzen);

Group: Pathological Sciences, Brussels, Belgium, 1965. First Place, Young Investigators' Competition, The American College of Cardiology, San Francisco,

California, 1973. Assubel Prize, Brussels, Belgium, 1979. Award for Outstanding Research, International Society for Heart Research, 1984-1985. Gold Medal of the City of Paris, 1986. Visiting Professorship of the British Heart Foundation, Royal Postgraduate Medical School, London W12

ONN, June 19-22, 1989. Philip Dow Lecture, Medical Augusta, Georgia, November 21, 1988. Lorenzini Lecture, Padova, Italy, June 14, 1989. Louis F. Bishop Lecture, American College of Cardiology, New Orleans, Louisiana, March 20, 1990. The Fifth George Burch Memorial Lecture, Association of University Cardiologists, Carmel, California,

January 17, 1991. ICI/Manchester University Prize Lecture, Manchester, United Kingdom, October 3, 1991. Founders Lecture in Basic Science, Association of Academic Surgery, Colorado Springs, Colorado,

November 22, 1991. Invited Lecturer, Societa Italiana Di Cardiologia, 52nd Congresso Nazionale, Rome, Italy December 10-13,

1991.

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2nd Robert Furchgott lecture, Mechanisms of Vasodilation, Glasgow, 1993. George E. Brown Lecture, American Heart Association, Atlanta, Georgia, U.S.A., November 9th, 1993. CARIM Lecture 1995, Universiteit of Limburg, Maastricht, The Netherlands, November 3, 1995. John T. Shepherd Lecture, Mayo Clinic and North-American chapter of the International Union of

Angiology, Rochester, MN, Oct. 5, 1996. 13th J. Bekaert Memorial Lecture, Antwerpen, Belgium, January 18th, 2000. Thirtieth Annual Distinguished Lecture in Pharmacology, Fred W. Schueler Lecture, Tulane Medical

School, New-Orleans, Louisiana, USA, June 2, 2000. John Croker Lecture, American Society of Pharmacology and Experimental Therapeutics, Boston, USA,

June 7th, 2000. Chinese University of Hong-Kong. Distinguished Visiting Scholar 2000-2001, March 2001. Institute of Scientific Information, Highly cited database researchers, 2001. Ariens Lecture, The Dutch Pharmacological Society, Lenteren, March 1st, 2002. Neufeld Lecture, The International Society of Cardiovascular Pharmacotherapy, Montreal, March 19th,

2002. ESC Lecture on Basic Science, The European Society of Cardiology, Vienna, September 1st, 2003.

John Vane Lecture and Medal, 2003. The British Pharamacological Society.

Carl J. Wiggers Award, American Society of Physiology, 2006. ‘Officer of the Crown Order’ awarded by the Belgium government, 2006. Honorary Fellow of the British Pharmacological Society, 2006. Honorary Fellow, Academie Royale de Medecine de Belgique, 2006. Mayo Clinic Distinguished Alumni Award, Mayo Clinic, 2007. Paul M. Vanhoutte Distinguished Lectureship in Vascular Pharmacology, American Society for

Pharmacology and Experimental Therapeutics, 2008. Governor for Hong Kong, International Society of Cardiovascular Pharmacotherapy, 2008. The Seventeenth Annual Thomas G. Muldoon Memorial Lecture, Medical College of Georgia, 2008. The Novartis Lecture, High Blood Pressure Research Council, American Heart Association, 2010.

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The Alexander Schirger Lectureship on Vascular Pathology, Mayo Clinic, 2011. ADMINISTRATIVE RESPONSIBILITIES: Member, Research Committee, Universitaire Instelling Antwerpen, University of Antwerp, Wilrijk,

Belgium, 1974-1976 and 1978-1981. Head, Division of Internal Medicine, Department of Medicine, Universitaire Instelling Antwerpen,

University of Antwerp, Wilrijk, Belgium, 1977-1979. Chairman, Committee on Animal Facilities, Universitaire Instelling Antwerpen, University of Antwerp,

Wilrijk, Belgium, 1978-1979. Director, Center for Experimental Therapeutics, Department of Medicine, Baylor College of Medicine,

Houston, Texas, U.S.A., 1989-1993. Vice-President, Discovery Research, Institut de Recherches Internationales Servier, Courbevoie, France,

1992-Present. Member, Scientific Advisory Board of the Foundation for Cardiovascular Research, Bern, 1994-present. International Union of Pharmacology, Secretary-General, 1998-2002, President, 2002-2006. Scientific council, Doctoral School of the University Paris VII, 2002-present. Director, BioPharmaceutical Development Centre, University of Hong Kong, 2003-present. Member, Advisory Board of the HKU Spinal Cord Injury Fund, University of Hong Kong, 2007- MEMBERSHIPS: 1) Academies: Academia Europea Academie Nationale de Pharmacie [Paris, France] Academie Royale de Medecine de Belgique Brasilian Academy of Medicine Koninklijke Akademie voor Geneeskunde van België 2) Scientific Societies: American College of Angiology, Fellow American College of Cardiology, Fellow

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American Heart Association, Council on Circulation, Fellow American Heart Association, Council on High Blood Pressure Research, Fellow American Heart Association, Stroke Council, Fellow American Physiological Society, Member American Physiological Society, Cardiovascular Section, Fellow American Society for Clinical Investigation, emeritus Member American Society for Pharmacology and Experimental Therapeutics, Member Argentine Society of Cardiology, Corresponding Member. Asian Society of Vascular Biology, Founder, President. Association of American Physicians, Member French Pharmacological Society, Member, Vice-President Belgian Society for Physiology and Pharmacology, Member British Pharmacological Society, Honorary Fellow Collège Français de Pathologie Vasculaire, Member European Biomedical Research Association, Founder Member European Society for Clinical Investigation European Society of Cardiology Hong Kong Pharmacology Society, President [2009-present] International Society of Hypertension International Society on Endothelialization in Cardiovascular Surgery, Founding Member International Union of Pharmacology (IUPHAR), Secretary-General, 1998-2002, President, 2002-present International Academy of Cardiovascular Sciences, Fellow Board of Directors, Member International Union of Pharmacology (IUPHAR), Executive Committee, member (1998-present),

Secretary-General (1998-2002), President (2002-2006), Past President (2006-present) Molecular Medicine Society, Member

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North American Vascular Biology Organization (NAVBO), Member Serotonin Club, Founder; Member; Past-President Society for Vascular Medicine and Biology, Fellow The Inter-American Society of Hypertension, member 3) Honorary Memberships: The Physiological Society (London) Indian Academy of Neurosciences Chinese Pharmacological Society Collège Français de Pathologie Vasculaire German Society of Angiology Société Française de Cardiologie International Union of Angiology EDITORSHIPS: Consulting Editor Cardiovascular Research 2012-2015 Editor-in-Chief: Journal of Cardiovascular Pharmacology, 1989-2007 Associate Editor: Journal of the Neurological Sciences, 1986-1992 American Journal of Physiology: Heart and Circulatory Physiology, 1987-1992 News in Physiological Science, 1987-1992 Journal of Vascular Medicine and Biology, 1989-1993 EDITORIAL BOARDS (past and present): Acta Pharmacologica Sinica (Chairman International Advisory Board)

Acta Physiologica Sinica

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Actualites Medicales Internationales en Angiologie

American Journal of Hypertension

American Journal of Physiology: Lung Cellular and Molecular Physiology

American Journal of Physiology: Heart and Circulatory Physiology

Angiology: The Journal of Vascular Diseases

Archives Internationales de Pharmacodynamic et de Therapie

Blood Vessels

Brazilian Journal of Medical and Biological Research

British Journal of Pharmacology

British Journal of Pharmacology (Special Adviser)

Cardiovascular Diabetology

Cardiovascular Drug Reviews

Cardiovascular Drugs and Therapy

Cardiovascular Medicine

Cardiovascular Therapeutics

Chinese Journal of Cardiovascular Pharmacology

Circulation

Circulation Journal - International Advisory Board (IAB) members

Circulation Research

Coronary Artery Disease

Current Cardiology R.eviews

Current Drugs: Serotonin

Current Opinion in Nephrology & Hypertension

Current Opinion in Pharmacology

Endothelium

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Heart and Vessels

High Blood Pressure and Cardiovascular Prevention

Hypertension

Hypertension Research

Hypertension Research Clinical and Experimental

Investigational Drugs Research Alerts : Anti-atherosclerotic Agents

IUPHAR newsletter “Pharmacology International”

Journal de Pharmacologie, Paris

Journal für Kardiologie - Austrian Journal for Heart and Circulation disease

Journal of Cardiovascular Pharmacology

Journal of Cardiovascular Pharmacology and Therapeutics

Journal of Diabetes

Journal of Hypertension

Journal of Pharmacology and Experimental Therapeutics

Journal of the Autonomic Nervous System

Journal of the Neurological Sciences

Journal of Vascular Medicine and Biology

Journal of Vascular Research (Blood Vessels)

Microcirculation

Neurochemistry International

Pharmacology Research

Pulmonary Pharmacology

The Netherlands Journal of Medicine

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BIBLIOGRAPHY THESES: 1 Vanhoutte, P.M. Onderzoekingen over de regeling van de bloedsomloop bij spierarbeid. Universitaire

Wedstrijd. Thesis, pp. 1-132, 1964. 2. Vanhoutte, P.M. Akute hypovolemie en cardiovasculaire aanpassing bij spierarbeid. Wedstrijd voor

Reisbeurzen. Thesis, pp. 1-77, 1965. 3. Vanhoutte, P.M. Cholinergische mechanismen in vasculair glad spierweefsel. Thesis, Antwerpen, pp.

1-181, 1973. BOOKS: A.Author 1. Shepherd, J.T. and Vanhoutte, P.M. "Veins and their Control." W.B. Saunders, Philadelphia, pp.

1-269, 1975. 2. Shepherd, J.T. and Vanhoutte, P.M. "The Human Cardiovascular System. Facts and Concepts."

English Edition: Raven Press, New York, pp. 1-351, 1979; Japanese Edition: Nishimura Co., Ltd., Tokyo, pp. 1-363, 1983.

3. Lüscher, T.F. and Vanhoutte, P.M. "The Endothelium: Modulator of Cardiovascular Function."

CRC Press, Inc., Boca Raton, pp. 1-228, 1990. 4. Félétou, M. and Vanhoutte, P.M. “EDHF: The Complete Story” CRC Taylor and Francis, Boca

Raton, pp. 1-298, 2006. B.Editor 1. "Mechanisms of Vasodilatation", Eds. Vanhoutte, P.M. and Leusen, I., Karger S., Basel, pp. 1-

307, 1978. 2. "Vascular Neuroeffector Systems", Eds. Bevan, J.A., Godfraind, T., Maxwell, R.A. and

Vanhoutte, P.M. Raven Press, New York, pp. 1-4-1, 1980. 3. "Vasodilatation", eds. Vanhoutte, P.M. and Leusen, I. Raven Press, New York, pp. 1-523, 1981. 4. "5-Hydroxytryptamine in Peripheral Reactions", eds. De Clerck, F., and Vanhoutte, P.M. Raven

Press, New York, pp. 1-232, 1982. 5. "Cardiovascular Pharmacology of the Prostaglandins", eds. Herman, A.G., Vanhoutte, P.M.,

Denolin, H. and Goossens, A. Raven Press, New York, pp. 1-456, 1982.

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6. "Vasodilator Mechanisms", eds. Vanhoutte, P.M., and Vatner, S.F., Karger, S. Basel, pp. 1-283, 1984.

7. "Serotonin and the Cardiovascular System", ed. Vanhoutte, P.M. Raven Press, New York, pp. 1-

288, 1985. 8. "Calcium Entry Blockers and Tissue Protection", eds. Godfraind, T., Vanhoutte, P.M., Govoni, S.

and Paoletti, R. Raven Press, New York, pp. 1-261, 1985. 9. "Central and Peripheral Mechanisms of Cardiovascular Regulation", eds. Magro, A., Osswald,

W., Reis, D. and Vanhoutte, P.M. Plenum Press, New York and London, pp. 1-544, 1986. 10. "The Endothelium: Relaxing and Contracting Factors", ed. Vanhoutte, P.M. The Humana Press,

Clifton, pp. 1-543, 1988. 11. "Vasodilatation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium" Ed.

Vanhoutte, P.M. Raven Press, New York, pp. 1-572. 12. "Calcium Antagonists: Pharmacology and Clinical Research", Eds. Vanhoutte, P.M., Paoletti, R.

and Govoni, S. Annals of the New York Academy of Sciences, 522: 1-802, 1988. 13. "Serotonin: From Cell Biology to Pharmacology and Therapeutics", eds. Paoletti, R., Vanhoutte,

P.M., Brunello, N. and Maggi, F.M. Kluwer Academic Publishers, Dordrecht/Boston/London, pp. 1-668, 1990.

14. "Endothelium-derived Relaxing Factors", eds. Rubanyi, G.M. and Vanhoutte, P. M., Karger, S.

Basel, pp 1-337, 1990. 15. "Endothelium-derived Contracting Factors", eds. Rubanyi, G.M. and Vanhoutte, P. M., Karger, S.

Basel, pp 1-237, 1990. 16. "Cardiovascular System, Hypertension and Serotonin Antagonists", eds. Paoletti, R., Vanhoutte,

P. M., Brunello, N. and Maggi, F. M. Kluwer Academic Publishers, Dordrecht/Boston/London. 17. "The Coronary Circulation in Physiological and Pathophysiological States", eds. Nakamura, M.

and Vanhoutte, P.M. Springer-Verlag, Tokyo, pp.1-160, 1991. 18. "Mechanisms of Vasodilation", eds. Vanhoutte, P.M. and Stoclet, J.C., Karger, S. Basel, pp. 1-

332, 1990. 19. "Fish Oil and Blood-Vessel Wall Interactions", eds. Vanhoutte, P.M., Ph. Douste-Blazy, John

Libbey, Paris, pp. 1-162, 1991. 20. "Return Circulation and Norepinephrine: An Update", eds. Vanhoutte, P.M. John Libbey, Paris,

pp. 1-237, 1991. 21. "Serotonin From Cell Biology to Pharmacology and Therapeutics", eds. Vanhoutte, P.M., Saxena,

P.R., Paoletti, R., Brunello, N. and Jackson, A.S. Kluwer Academic Publishers, pp. 1-434, 1993.

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22. "Cardiovascular Pharmacology and Therapeutics", eds Singh, B.N., Dzau, V.J., Vanhoutte, P.M. and Woosley, R.L. Churchill Livingstone, pp.1-1231, 1993.

23. "Endothelium-Derived Hyperpolarizing Factor", eds Vanhoutte, P.M. Harwood Academic

Publishers, pp. 1-338, 1996. 24. "Farmacologia e Terapia Cardiovasculare", eds Singh, B.N., Dzau, V.J., Vanhoutte, P.M. and

Woosley, R.L. Guidotti, pp.1-707, 1996. 25. “The IUPHAR Compendium of Receptor Characterization”, eds. T. Godfraind, P. Vanhoutte, W.

Ruffolo, P. Humphrey, Published by IUPHAR Media, London, 1998. 26. "Endothelium-Derived Hyperpolarizations" Ed. P.M. Vanhoutte. Harwood Academic publishers,

pp. 1-436, 1999. 27. « Nei Pi Yuan Xing Chao Ji Hua Yin Zi » (EDHF). ed. P.M. Vanhoutte. Translation Rui-Jan Xiu,

Books of the World, Beijing, pp. 1-148, 1999. 28. "EDHF 2000" Ed. P.M. Vanhoutte. Taylor & Francis (London and New York), pp. 1-502, 2001. 29. “Selective and Specific If Inhibition in Cardiovascular Disease”, eds Singh, B.N. and Vanhoutte,

P.M., Lipincott Williams & Wilkins (London), pp. 1-134, 2003. 30. "EDHF 2002" Ed. P.M. Vanhoutte. Taylor & Francis (London and New York),pp. 1-354, 2004. 31. “Cardiovascular Pharmacology – Heart and Circulation” Ed. P.M. Vanhoutte. Academic Press,

pp. 1-331, 2010. 32. “Cardiovascular Pharmacology: Endothelial control” – Advances in Pharmacology 60. Ed. P.M.

Vanhoutte. Academic Press, pp. 85-106, 2010.

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ORIGINAL RESEARCH PAPERS: OR-1 Lacroix, E., Vanhoutte, P.M. and Leusen, I. L'activité phosphorylasique du myocarde sous

'influence de la réserpine. Arch. Int. Pharmacodyn. Ther. 138: 329-333, 1962. OR-2 Vanhoutte, P.M. L'adaptation cardio-vasculaire du chien anesthésié à un exercice musculaire

imposé. C.R. Soc. Biol. 158: 2489-2491, 1964. OR-3 Vanhoutte, P.M. Rôle des presso-récepteurs artériels dans l'adaptation cardiovasculaire au cours

d'un exercice musculaire imposé chez le chien anesthésié. Arch. Int. Pharmacodyn. Ther. 155: 463-466, 1965.

OR-4 Vanhoutte, P.M. Adaptation circulatoire du chien anesthésié à un exercice musculaire imposé en

état d'hypovolémie. C.R. Soc. Biol. 159: 2274-2276, 1965. OR-5 Vanhoutte, P.M. Bloedvolume en aanpassing van de hemodynamiek bij spierarbeid.

Kontaktgroepen N.F.W.G.0., pp. 139-146, 1966. OR-6 Vanhoutte, P.M. Influence de l'hémorragie sur le changement de l'hématocrite au cours de

l'exercice musculaire. C.R. Soc. Biol. 160: 1751-1753, 1966. OR-7 Vanhoutte, P.M. and Lacroix, E. The cardiovascular adaptation of the anesthetized dog to

muscular work after graded hemorrhage. Role of the arterial pressoreceptors. Arch. Int Physiol. Biochem. 74: 223-234, 1966.

OR-8 Vanhoutte, P.M., Lacroix, E. and Leusen, I. The cardiovascular adaptation of the dog to muscular

exercise. Role of the arterial pressoreceptors. Arch. Int. Physiol. Biochem. 74: 201-222, 1966. OR-9 Vanhoutte, P.M. and Leusen, I. The cardiovascular adaptation of the dog to muscular exercise

after graded hemorrhages. Arch. Int. Physiol. Biochem. 74: 185-200, 1966. OR-10 Vanhoutte, P.M. and Leusen, I. Adaptation cardiovasculaire du chien non anesthésié, en état

d'hypovolémie, à un exercice musculaire modéré. Arch. Int. Pharmacodyn. Ther. 162: 236-238, 1966.

OR-11 Clément, D. and Vanhoutte, P.M. Effects of monoamines on the capacity of isolated veins. Arch.

Int. Pharmacodyn. Ther. 166: 181-183, 1967. OR-12 Vanhoutte, P.M. Influence de variations du pH sur la reactivite de fragments de veines isolees du

chien. C.R. Soc. Biol. 161: 2318-2320, 1967. OR-13 Vanhoutte, P.M. Clément, D. and Leusen, I. Response characteristics of isolated veins to electric

stimulation. Arch. Int. Pharmacodyn. Ther. 167: 495-497, 1967. OR-14 Vanhoutte, P.M., Clément, D. and Leusen, I. The reactivity of isolated veins to electrical

stimulation. Arch. Int. Physiol. Biochem. 75: 641-657, 1967. OR-15 Vanhoutte, P.M. Influence des concentrations des ions Ca, Na et H sur la réactivité de fragments

de veines isolées du chien. C.R. Soc. Biol. 162: 800-802, 1968.

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OR-16 Vanhoutte, P.M., and Clément, D. Effect of pH and PC02 changes on the reactivity of isolated

venous smooth muscle. Arch. Int. Physiol. Biochem. 76: 144-146, 1968. OR-17 Vanhoutte, P.M., Waes, J. and Devriendt, G. A method for continuous registration of isobaric

capacity reactions of isolated veins. Arch. Int. Physiol. Biochem. 76: 164-165, 1968. OR-18 Brender, D., Vanhoutte, P.M. and Shepherd, J.T. Potentiation of adrenergic venomotor responses

in dogs by cardiac glycosides. Circ. Res. 25: 597-606, 1969. OR-19 Clément, D., Vanhoutte. P.M. and Leusen, I. Capacitance reactions of isolated veins to

monoamines and acetylcholine. Arch. Int. Physiol. Biochem. 77: 73-87, 1969. OR-20 Vanhoutte, P.M. and Leusen, I. The reactivity of isolated venous preparations to electric

stimulation. Pflugers Arch. 306: 341-353, 1969. OR-21 Vanhoutte, P.M. and Shepherd, J.T. Activity and thermosensitivity of canine cutaneous veins

after inhibition of monoamine oxidase and catechol-O-methyl transferase. Circ. Res. 25: 607-616, 1969.

OR-22 Vanhoutte, P.M. Effets de l'hypoxie sur la réactivité du muscle lisse veineux. J. de Physiol. 62:

456, 1970. OR-23 Vanhoutte, P.M. Mécanismes adrénergiques et réactivité des veines cutanéees du chien aux

variations de la température locale. C.R. Soc. Biol. 164: 2666-2671, 1970. OR-24 Vanhoutte, P.M. and Lorenz, R.R. Effect of temperature on the reactivity of saphenous,

mesenteric, and femoral veins of the dog. Am. J. Physiol. 218: 1746-1750, 1970. OR-25 Vanhoutte, P.M. and Shepherd, J.T. Effect of temperature on reactivity of isolated cutaneous

veins of the dog. Am. J. Physiol. 218: 187-190, 1970. OR-26 Vanhoutte, P.M. and Shepherd, J.T. Effect of cooling on beta-receptor mechanisms in isolated

cutaneous veins of the dog. Microvasc. Res. 2: 454-461, 1970. OR-27 Hendricks, G. and Vanhoutte, P.M. Variations in external calcium concentration and sensitivity of

venous smooth muscle to temperature changes. Arch. Int. Physiol. 79: 169-170, 1971. OR-28 Vanhoutte, P.M. and Leusen, I. Effect of hypoxia on reactivity of cutaneous and mesenteric veins

of the dog. In: Vascular Smooth Muscle, ed. E. Betz. Springer Verlag, Berlin, pp. 138-139, 1972. OR-29 Vanhoutte, P.M., Lorenz, R.R. and Tyce, G.M. Inhibition of norepinephrine-3H-release from

sympathetic nerve endings in veins by acetylcholine. J. Pharmacol. Exp. Ther. 185: 386-394, 1973.

OR-30 Vanhoutte, P.M. and Shepherd, J.T. Venous relaxation caused by acetylcholine acting on the

sympathetic nerves. Circ. Res. 32: 259-267, 1973.

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OR-31 Vanhoutte, P.M. Inhibition by acetylcholine of adrenergic neurotransmission in vascular smooth muscle. Circ. Res. 34: 317-326, 1974.

OR-32 Lorenz, R.R. and Vanhoutte, P.M. Inhibition of adrenergic neurotransmission in isolated veins of

the dog by potassium ions. J. Physiol. 246: 479-500, 1975. OR-33 Muldoon, S.M., Vanhoutte, P.M., Lorenz, R.R. and Van Dyke, R.A. Venomotor changes caused

by halothane acting on the sympathetic nerves. Anesthesiology 43: 41-48, 1975. OR-34 Vanhoutte, P.M., Verbeuren. T.J. and Lorenz, R.R. Effects of potassium ions on nerve endings

and effector cells in adrenergically innervated vascular smooth muscle. Colloques INSERM, Paris 50: 425-442, 1975.

OR-35 Muldoon, S.M., Verbeuren, T.J. and Vanhoutte, P.M. Effects of amide-linked local anesthetics on

adrenergic neuroeffector junction in cutaneous veins of dog. J. Pharmacol. Exp. Ther. 196: 723-736, 1976.

OR-36 Vanhoutte, P.M. Effects of anoxia and glucose depletion on isolated veins of the dog. Am. J.

Physiol. 230: 1261- 1268, 1976. OR-37 Vanhoutte, P.M. and Verbeuren, T.J. Depression by local cooling of 3H-norepinephrine release

evoked by nerve stimulation in cutaneous veins. Blood Vessels 13: 92-99, 1976. OR-38 Vanhoutte, P.M. and Verbeuren, T.J. Inhibition by acetylcholine of 3H-norepinephrine release in

cutaneous veins after alpha-adrenergic blockade. Arch. Int. Pharmacodyn. Ther. 221: 344-346, 1976.

OR-39 Vanhoutte, P.M. and Verbeuren, T.J. Inhibition by acetylcholine of the norepinephrine release

evoked by potassium in canine saphenous veins. Circ. Res. 39: 263-269, 1976. OR-40 Verbeuren, T.J. and Vanhoutte, P.M. Acetylcholine inhibits potassium evoked release of 3H-

norepinephrine in different blood vessels of the dog. Arch. Int. Pharmacodyn. Ther. 221: 347-350, 1976.

OR-41 Collis, M.G. and Vanhoutte, P.M. Vascular reactivity of isolated perfused kidneys from male and

female spontaneously hypertensive rats. Circ. Res. 41: 759-767, 1977. OR-42 Muldoon, S.M., Janssens, W.J., Verbeuren, T.J. and Vanhoutte, P.M. Alpha-adrenergic blocking

properties of droperidol on isolated blood vessels of the dog. Br. J. Anaesthesia 49: 211-216, 1977.

OR-43 Vanhoutte, P.M., Van Nueten, J.M., Verbeuren, T.J. and Laduron, P.M. Differential effects of the

isomers of tetramisole on adrenergic neurotransmission in cutaneous veins of dog. J. Pharmacol. Exp. Ther. 200: 127-140, 1977.

OR-44 Van Nueten, J.M., Van Ree, J.M. and Vanhoutte, P.M. Inhibition by met-enkephalin of peristaltic

activity in the guinea pig ileum, and its reversal by naloxane. Eur. J. Pharmacol. 41: 341-342, 1977.

17

OR-45 Verbeuren, T.J., Coen. E. and Vanhoutte, P.M. Determination of 3H-norepinephrine and its metabolites in superfusate from isolated blood vessels. Arch. Int. Pharmacodyn. Ther. 227: 171-174, 1977.

OR-46 Verhaeghe, R.H., Vanhoutte, P.M. and Shepherd, J.T. Inhibition of sympathetic

neurotransmission in canine blood vessels by adenosine and adenine nucleotides. Circ. Res. 40: 208-215, 1977.

OR-47 Collis, M.G. and Vanhoutte, P.M. Increased renal vascular reactivity to angiotensin II but not to

nerve stimulation or exogenous norepinephrine in renal hypertensive rats. Circ. Res. 43: 544-552, 1978.

OR-48 Collis, M.G. and Vanhoutte, P.M. Neuronal and vascular reactivity in isolated perfused kidneys

during the development of spontaneous hypertension. Clin. Sci. Mol. Med. 55: 233s-235s, 1978. OR-49 Curro, F.A., Greenberg, S., Verbeuren, T.J. and Vanhoutte, P.M. Interaction between alpha-

adrenergic and serotonergic activation of canine saphenous veins. J. Pharmacol. Exp. Ther. 207: 936-949, 1978.

OR-50 Herman, A.G., Verbeuren, T.J., Moncada, S. and Vanhoutte, P.M. Effect of prostacyclin on

myogenic activity and adrenergic neuroeffector interaction in canine isolated veins. Prostaglandins 16: 911-921, 1978.

OR-51 Janssens, W.J. and Vanhoutte, P.M. Instantaneous changes of alpha-adrenoceptor affinity caused

by moderate cooling in canine cutaneous veins. Am. J. Physiol. 234: H330-H337, 1978. OR-52 Muldoon, S.M., Vanhoutte, P.M. and Tyce, G.M. Norepinephrine metabolism in canine

saphenous vein: prevalence of glycol metabolites. Am. J. Physiol. 234: H235-H243, 1978. OR-53 Van Hee, R.H. and Vanhoutte, P.M. Cholinergic inhibition of adrenergic neurotransmission in the

canine gastric artery. Gastroenterology 74: 1266-1270, 1978. OR-54 Verbeuren, T.J., Janssens, W.J. and Vanhoutte, P.M. Effects of moderate acidosis on adrenergic

neurotransmission in canine saphenous veins. J. Pharmacol. Exp. Ther. 206: 105-114, 1978. OR-55 Collis, M.G., De Mey, C. and Vanhoutte, P.M. Enhanced release of noradrenaline in the kidney of

the young spontaneously hypertensive rat. Clin. Sci. 57: 233s-234s, 1979. OR-56 De Mey, J.G., Burnstock, G. and Vanhoutte. P.M. Modulation of the evoked release of

noradrenaline in canine saphenous vein via pre-synaptic receptors for adenosine but not ATP. Eur. J. Pharmacol. 55: 401-405, 1979.

OR-57 Driessens, M. and Vanhoutte, P.M. Vascular reactivity of the isolated tibia of the dog. Am. J.

Physiol. 236: H904-H908, 1979. OR-58 Lorenz, R.R., Vanhoutte, P.M. and Shepherd. J.T. Interaction between neuronal amine uptake and

prejunctional alpha-adrenergic receptor activation in smooth muscle from canine blood vessels and spleen. Blood Vessels 16: 113-125, 1979.

18

OR-59 Vanhoutte, P.M., Coen, E.P., De Ridder, W.J. and Verbeuren, T.J. Evoked release of endogenous norepinephrine in the canine saphenous vein. Inhibition by acetylcholine. Circ. Res. 45: 608-614, 1979.

OR-60 Vermeire, P.A. and Vanhoutte, P.M. Inhibitory effects of catecholamines in isolated canine

bronchial smooth muscle. J. Appl. Physiol. 46: 787-791, 1979. OR-61 Vercruysse, P., Bossuyt, P., Hanegreefs, G., Verbeuren, T.J. and Vanhoutte, P.M. Gallamine and

pancuronium inhibit pre- and post-junctional muscarinic receptors in canine saphenous veins. J. Pharmacol. Exp. Ther. 209: 225-230, 1979.

OR-62 Webb, R.C. and Vanhoutte, P.M. Sensitivity to noradrenaline in isolated tail arteries from

spontaneously hypertensive rat. Clin. Sci. 57: 31s-33s, 1979. OR-63 Collis, M.G., De Mey, Ch. and Vanhoutte, P.M. Renal vascular reactivity in the young

spontaneously hypertensive rat. Hypertension 2: 45-52, 1979. OR-64 Dalemans, P., Janssens, W.J., Verbeuren, T.J. and Vanhoutte, P.M. Effect of naturally occurring

catecholamines on adrenergic neuroeffector interaction in the canine saphenous vein. In: Presynaptic Receptors, eds. S. Langer, K. Starke and M.L. Dubocovich. Advances in the Biosciences, Pergamon Press, Oxford, vol. 18, pp. 111-116, 1979.

OR-65 De Mey, J.G. and Vanhoutte, P.M. Comparison of the responsiveness of cutaneous veins of dog

and rabbit to adrenergic and cholinergic stimulation. Blood Vessels 17: 27-43, 1980. OR-66 De Mey, J. and Vanhoutte, P.M. Interaction between Na+,K+ exchanges and the direct inhibitory

effect of acetylcholine on canine femoral arteries. Circ. Res. 46: 826-836, 1980. OR-67 De Mey, J. and Vanhoutte, P.M. Effect of removal and substitution of potassium ions on the

adrenergic and cholinergic reactivity in canine femoral artery. Eur. J. Pharmacol. 67: 159-164, 1980.

OR-68 Lorenz, R.R., Powis, D.A., Vanhoutte, P.M. and Shepherd, J.T. The effects of

acetylstrophanthidin and ouabain on sympathetic adrenergic neuroeffector junction in canine vascular smooth muscle. Circ. Res. 47: 845-854, 1980.

OR-69 Rusch, N.J., De Mey, J.G. and Vanhoutte, P.M. Effect of BL-5111-A, prazosin and phentolamine

on responses of canine cutaneous veins to activation. Arch. Int. Pharmacodyn. Ther. 244: 341-343, 1980.

OR-70 Vanhoutte, P.M., Verbeuren, T.J. and Van Nueten, J.M. Effect of lidoflazine on systemic arteries

and veins. Angiology 31: 581-593, 1980. OR-71 Van Nueten, J.M., Van Beek, J. and Vanhoutte, P.M. Inhibitory effect of lidoflazine on

contractions of isolated canine coronary arteries caused by norepinephrine, 5-hydroxytryptamine, high potassium, anoxia and ergonovine maleate. J. Pharmacol. Exp. Ther. 213: 179-187, 1980.

OR-72 Van Nueten, J.M. and Vanhoutte, P.M. Effect of the Ca2+ antagonist lidoflazine on normoxic and

anoxic contractions of canine coronary arterial smooth muscle. Eur. J. Pharmacol. 64: 173-176, 1980.

19

OR-73 Webb, R.C., Vanhoutte, P.M. and Bohr, D.F. Inactivation of released norepinephrine in rat tail

artery by neuronal uptake. J. Cardiovasc. Pharmacol. 2: 121-132, 1980. OR-74 Webb, R.C., Vanhoutte, P.M. and Bohr, D.F. Calcium efflux in rat tail artery during potassium

induced relaxation. Proc. Soc. Exp. Biol. Med. 164: 252-256, 1980. OR-75 Collis, M.G. and Vanhoutte, P.M. Tachyphylaxis to 5-hydroxytryptamine in perfused kidneys

from spontaneously hypertensive and normotensive rats. J. Cardiovasc. Pharmacol. 3: 229-235, 1981.

OR-76 De Mey, J.G. and Vanhoutte, P.M. Uneven distribution of postjunctional alpha1 and alpha2-like

adrenoceptors in canine arterial and venous smooth muscle. Circ. Res. 48: 875-884, 1981. OR-77 De Mey, J.G. and Vanhoutte, P.M. Role of the intima in cholinergic and purinergic relaxation of

isolated canine femoral arteries. J. Physiol. 316: 347-355, 1981. OR-78 Rorie, D.K., Rusch, N.J., Shepherd, J.T., Vanhoutte, P.M. and Tyce, G. Prejunctional inhibition

of norepinephrine release caused by acetylcholine in human saphenous vein. Circ. Res. 49: 337-341, 1981.

OR-79 Rusch, N.J., Shepherd, J.T. and Vanhoutte, P.M. The effect of profound cooling on adrenergic

neurotransmission in canine cutaneous veins. J. Physiol. 311: 57-65, 1981. OR-80 Rusch, N.J., Shepherd, J.T., Vanhoutte, P.M. and Webb, R.C. Different behavior of the resistance

vessels of the human calf and forearm during contralateral isometric exercise, mental stress and abnormal respiratory movements. Circ. Res. 48: I-118-I-30, 1981.

OR-81 Van Nueten, J.M. and Vanhoutte, P.M. Selectivity of calcium antagonism and serotonin

antagonism with respect to venous and arterial tissues. Angiology 32: 476-484, 1981. OR-82 Verbeuren, T.J., Coen, E., De Ridder, W. and Vanhoutte, P.M. Comparison of the responsiveness

of isolated arteries and veins taken from the same dogs 17 days apart. Experientia 37: 590-591, 1981.

OR-83 Webb, R.C., Lockette, W.E., Vanhoutte, P.M. and Bohr, D.F. Monovalent ion specificity of the

electrogenic sodium pump in vascular smooth muscle. Proc. Soc. Exp. Biol. Med. 166: 457-461, 1981.

OR-84 Webb, R.C., Rusch, N.J. and Vanhoutte, P.M. Influence of sex differences and oral contraceptives

on forearm reactive hyperemia. Blood Vessels 18: 161-170, 1981. OR-85 Webb, R.C., Vanhoutte, P.M. and Bohr, D.F. Adrenergic neurotransmission in vascular smooth

muscle from spontaneously hypertensive rats. Hypertension 3: 93-103, 1981. OR-86 Driessens, M. and Vanhoutte, P.M. Effect of calcitonin, hydrocortisone and parathyroid hormone

on canine bone blood vessels. Am. J. Physiol. 241: H91-H94, 1981. OR-87 Janssens, W.J., Verbeuren, T.J. and Vanhoutte, P.M. Effect of moderate cooling on adrenergic

neuroeffector interaction in canine cutaneous veins. Blood Vessels 18: 281-295, 1981.

20

OR-88 Vanhoutte, P.M., Collis, M.G., Janssens, W.J. and Verbeuren, T.J. Calcium dependence of

prejunctional inhibitory effects of adenosine and acetylcholine on adrenergic neurotransmission in canine saphenous veins. Eur. J. Pharmacol. 72: 189-198, 1981.

OR-89 Van Nueten, J.M., Janssen, P.A.J., Van Beek, J., Xhonneux, R., Verbeuren, T.J. and Vanhoutte,

P.M. Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors. J. Pharmacol. Exp. Ther. 218: 217-230, 1981.

OR-90 De Mey, Ch. and Vanhoutte, P.M. Effect of age and spontaneous hypertension on the

tachyphylaxis to 5-hydroxytryptamine and angiotensin II in the isolated rat kidney. Hypertension 3: 718-724, 1981.

OR-91 Webb, R.C. and Vanhoutte, P.M. Cocaine-induced release of noradrenaline in rat tail artery. J.

Pharm. Pharmacol. 34: 134-136, 1981. OR-92 Verbeuren, T.J. and Vanhoutte, P.M. Deamination of released 3H-noradrenaline in the canine

saphenous vein. Naunyn Schmiedeberg's Arch. Pharmacol. 318: 148-157, 1982. OR-93 Webb, R.C. and Vanhoutte, P.M. Cocaine and contractile responses of vascular smooth muscle

from spontaneously hypertensive rats. Arch. Int. Pharmacodyn. Ther. 253: 241-256, 1981. OR-94 Vanhoutte, P.M., Browning, D., Coen, E., Verbeuren, T.J., Zonnekeyn, L. and Collis, M.G.

Decreased release of norepinephrine in the isolated kidney of the adult spontaneously hypertensive rat. Hypertension 4: 251-256, 1982.

OR-95 Van Nueten, J.M., Janssen, P.A.J., De Ridder, W. and Vanhoutte, P.M. Interaction between 5-

hydroxytryptamine and other vasoconstrictor substances in the isolated femoral artery of the rabbit; effect of ketanserin (R 41 468). Eur. J. Pharmacol. 77: 281-287, 1982.

OR-96 Marcelon, G., Verbeuren, T.J., Lauressergues, H. and Vanhoutte, P.M. Effect of ruscus aculeatus

on isolated canine cutaneous veins. Gener. Pharmacol. 14: 103-106, 1983. OR-97 Rooke, T., Cohen, R.A., Verbeuren, T.J. and Vanhoutte, P.M. Non-neurogenic inhibitory effect of

electrical impulses in isolated canine coronary arteries. Eur. J. Pharmacol. 80: 251-254, 1982. OR-98 De Mey, J.G., Claeys, M. and Vanhoutte, P.M. Endothelium-dependent inhibitory effects of

acetylcholine, adenosine triphosphate, thrombin and arachidonic acid in the canine femoral artery. J. Pharmacol. Exp. Ther. 222: 166-173, 1982.

OR-99 De Mey, J.G. and Vanhoutte, P.M. Na+-K+ exchanges in canine arterial and venous smooth

muscle. Am. J. Physiol. 243: H551-H559, 1982. OR-100 De Mey, J.G. and Vanhoutte, P.M. Heterogeneous behavior of the canine arterial and venous wall:

importance of the endothelium. Circ. Res. 51: 439-447, 1982. OR-101 De Mey, J.G. and Vanhoutte, P.M. Anoxia and endothelium dependent reactivity of the canine

femoral artery. J. Physiol. 335: 65-74, 1983.

21

OR-102 Vanhoutte, P.M. and Rimele, T.J. Calcium and -adrenoceptors in activation of vascular smooth muscle. J. Cardiovasc. Pharmacol. 4: S280-S286, 1982.

OR-103 Verbeuren, T.J. and Vanhoutte, P.M. Cocaine and neuronal uptake in the canine saphenous vein.

Naunyn Schmiedeberg's Arch. Pharmacol. 321: 207-212, 1982. OR-104 Cohen, R.A., Shepherd, J.T. and Vanhoutte, P.M. Prejunctional and postjunctional actions of

endogenous norepinephrine at the sympathetic neuroeffector junction in canine coronary arteries. Circ. Res. 52: 16-25, 1983.

OR-105 Lea, D.A., Rimele, T.J., Brubaker, R.F., Nagataki, S. and Vanhoutte, P.M. Effect of thymoxamine

on the human pupil. Exp. Eye Res. 36: 655-662, 1983. OR-106 Aarhus, L.L., Shepherd, J.T., Tyce, G.M., Verbeuren, T.J. and Vanhoutte, P.M. Contractions of

canine vascular smooth muscle cells caused by ouabain are due to release of norepinephrine from adrenergic nerve endings. Circ. Res. 52: 501-507, 1983.

OR-107 Rimele, T.J. and Vanhoutte, P.M. Effects of inhibitors of arachidonic acid metabolism and

calcium entry on responses to acetylcholine, potassium, and norepinephrine in the isolated canine saphenous vein. J. Pharmacol. Exp. Ther. 225: 720-728, 1983.

OR-108 Cohen, R.A., Shepherd, J.T. and Vanhoutte, P.M. Inhibitory role of the endothelium in the

response of isolated coronary arteries to Platelets. Science 221: 273-274, 1983. OR-109 Verbeuren, T.J., Lorenz, R.R., Aarhus, L.L., Shepherd, J.T. and Vanhoutte, P.M. Prejunctional

beta-adrenoceptors in human and canine saphenous veins. J. Autonomic Nervous System 8: 261-271, 1983.

OR-110 Boels, P.J., Verbeuren, T.J. and Vanhoutte, P.M. Tissue accumulation and release of newly

synthesized 3H-dopamine and 3H-noradrenaline in canine saphenous veins incubated with 3H-(-)-tyrosine. Naunyn Schmiedeberg's Arch. Pharmacol. 324: 7-14, 1983.

OR-111 Rimele, T.J., Rooke, T.W., Aarhus, L.L. and Vanhoutte, P.M. Alpha1-adrenoceptors and calcium

in isolated canine coronary arteries. J. Pharmacol. Exp. Ther. 226: 668-672, 1983. OR-112 Van Nueten, J.M., Van Beek, J. and Vanhoutte, P.M. Effect of Ca2+-entry blockade and

serotonergic antagonism on contractions of hypoxic isolated canine coronary arteries. Arch. Int. Pharmacodyn. Ther. 265: 172-176, 1983.

OR-113 Rooke, T.W., Rimele, T.J. and Vanhoutte, P.M. Relaxation of the canine saphenous vein

following brief transmural nerve stimulation. Am. J. Physiol. 245: HI073-HI076, 1983. OR-114 Cohen, R.A., Shepherd, J.T. and Vanhoutte, P.M. 5-Hydroxytryptamine can mediate

endothelium.dependent relaxation of coronary arteries. Am. J. Physiol. 245: H1077-H1080, 1983. OR-115 Vanhoutte, P.M., Aarhus, L.L., Coen, E., Lorenz, R.R., Rimele, T.J. and Verbeuren, T.J. The

effects of buflomedil on the responsiveness of canine vascular smooth muscle. J. Pharmacol. Exp. Ther. 227: 613-620, 1983.

22

OR-116 Van Nueten, J.M., De Ridder, W. and Vanhoutte, P.M. Ketanserin and vascular contractions in response to cooling. Eur. J. Pharmacol. 99: 329-332, 1984.

OR-117 Cohen, R.A., Shepherd, J.T. and Vanhoutte, P.M. Neurogenic cholinergic prejunctional inhibition

of sympathetic beta adrenergic relaxation in the canine coronary artery. J. Pharmacol. Exp. Ther. 229: 417-421, 1984.

OR-118 Cooke, J.P., Shepherd, J.T. and Vanhoutte, P.M. The effect of warming on adrenergic

neurotransmission in canine cutaneous vein. Circ. Res. 54: 547-553, 1984. OR-119 Lindblad, L.E., Shepherd, J.T. and Vanhoutte, P.M. Cooling augments platelet-induced

contraction of peripheral arteries of the dog. Proc. Soc. Exp. Biol. Med. 176: 119-122, 1984. OR-120 Rooke, T.W., Rimele, T.J. and Vanhoutte, P.M. Contractions of the canine coronary artery in

Ca2+-free solution. Am. J. Physiol. 247: H259-H263, 1984. OR-121 Lindblad, L.E., Lorenz, R.R., Shepherd, J.T. and Vanhoutte, P.M. Prolonged vibration of

cutaneous artery: absence of persisting after effects. Experientia 40: 1372-1373, 1984. OR-122 Rimele, T.J. and Vanhoutte, P.M. Effects of inhibitors of arachidonic acid metabolism and

calcium entry on hypoxic contractions of the isolated canine coronary artery. In: Calcium Antagonists: Mechanisms of Action on Cardiac Muscle and Vascular Smooth Muscle, eds. N. Sperelakis and J.B. Canfield, Martinez-Nijhoff, Boston, pp. 303-316, 1984.

OR-123 Cohen, R.A., Shepherd, J.T. and Vanhoutte, P.M. Endothelium and asymmetrical responses of the

coronary arterial wall. Am. J. Physiol. 247: H403-H408, 1984. OR-124 Rubanyi, G., Marcelon, G. and Vanhoutte, P.M. Effect of temperature on the responsiveness of

cutaneous veins to the extract of ruscus aculeatus. Gener. Pharmacol. 15:431-434, 1984. OR-125 McGoon, M.D. and Vanhoutte, P.M. Aggregating platelets contract isolated canine pulmonary

arteries by releasing 5-Hydroxytryptamine. J. Clin. Invest. 74: 828-833, 1984. OR-126 Flavahan, N.A., Rimele, T.J., Cooke, J.P. and Vanhoutte, P.M. Characterization of postjunctional

alpha1 and alpha2-adrenoceptors activated by exogenous or nerve-released norepinephrine in the canine saphenous vein. J. Pharmacol. Exp. Ther. 230: 699-705, 1984.

OR-127 Katusic, Z.S., Shepherd, J.T. and Vanhoutte, P.M. Vasopressin causes endothelium-dependent

relaxations of the canine basilar artery. Circ. Res. 55: 575-579, 1984. OR-128 Rimele, T.J., Aarhus, L.L., Lorenz, R.R., Rooke, T.W. and Vanhoutte, P.M. Pharmacology of

bucindolol in isolated canine vascular smooth muscle. J. Pharmacol. Exp. Ther. 231: 317-325, 1984.

OR-129 Rubanyi, G.R. and Vanhoutte, P.M. Endothelium-removal decreases relaxations of canine

coronary arteries caused by beta-adrenergic agonists and adenosine. J. Cardiovasc. Pharmacol. 7: 139-144, 1985.

OR-130 Rubanyi, G.M. and Vanhoutte, P.M. Inhibitors of prostaglandin synthesis augment ß-adrenergic

responsiveness in canine coronary arteries. Circ. Res. 56: 117-125, 1985.

23

OR-131 Flavahan, N.A., Aarhus, L.L., Rimele, T.J. and Vanhoutte, P.M. The respiratory epithelium

inhibits bronchial smooth muscle tone. J. Appl. Physiol. 58: 834-838, 1985. OR-132 Houston, D.S., Shepherd, J.T. and Vanhoutte, P.M. Adenine nucleotides, serotonin and

endothelium-dependent relaxations to platelets. Am. J. Physiol. 248: H389-H395, 1985. OR-133 Miller, V.M. and Vanhoutte, P.M. Endothelium-dependent contractions to arachidonic acid are

mediated by products of cyclo-oxygenase in canine veins. Am. J. Physiol. 248: H432-H437, 1985. OR-134 Vanhoutte, P.M., Cooke, J.P., Lindblad, L.E., Shepherd, J.T. and Flavahan, N.A. Modulation of

postjunctional -adrenergic responsiveness by local changes in temperature. Clin. Sci. 68: 121s-123s, 1985.

OR-135 Rubanyi, G.M., Lorenz, R.R. and Vanhoutte, P.M. Bioassay of endothelium-derived relaxing

factor(s). Inactivation by catecholamines. Am. J. Physiol. 249: H95-H101, 1985. OR-136 Rubanyi, G.M. and Vanhoutte, P.M. Hypoxia releases a vasoconstrictor substance from the

canine vascular endothelium. J. Physiol. 364: 45-56, 1985. OR-137 Rusch, N.J., Chyatte, D., Sundt, T.M., Jr. and Vanhoutte, P.M. 5-Hydroxytryptamine: source of

activator calcium in human basilar arteries. Stroke 16: 718-720, 1985. OR-138 Boels, P.J., Verbeuren, T.J. and Vanhoutte, P.M. Moderate cooling depresses the accumulation

and the release of newly synthesized catecholamines in isolated canine saphenous veins. Experientia 41: 1374-1377, 1985.

OR-139 Rubanyi, G.M. and Vanhoutte, P.M. Ouabain inhibits endothelium-dependent relaxations to

arachidonic acid in canine coronary arteries. J. Pharmacol. Exp. Ther. 235: 81-86, 1985. OR-140 Lorenz, R.R. and Vanhoutte, P.M. Prejunctional adrenergic inhibition by aggregating platelets in

canine blood vessels. Am. J. Physiol. 249: H685-H689, 1985. OR-141 Flavahan, N.A., Lindblad, L.E., Verbeuren, T.J., Shepherd, J.T. and Vanhoutte, P.M. Cooling

and alpha1 and alpha2-adrenergic responses in cutaneous veins: role of receptor-reserve. Am. J. Physiol. 249: H950-H955, 1985.

OR-142 Cooke, J.P., Rimele, T.J., Flavahan, N.A. and Vanhoutte, P.M. Nimodipine and inhibition of

alpha-adrenergic activation of the isolated canine saphenous vein. J. Pharmacol. Exp. Ther. 234: 598-602, 1985.

OR-143 Miller, V.M. and Vanhoutte, P.M. Endothelial alpha2-adrenoceptors in canine pulmonary and

systemic blood vessels. Eur. J. Pharmacol. 118: 123-129, 1985. OR-144 Rubanyi, G.M., Schwartz, A. and Vanhoutte, P.M. The calcium agonists Bay K 8644 and (+)

202,791 stimulate the release of endothelial relaxing factor from canine femoral arteries. Eur. J. Pharmacol. 117: 143-144, 1985.

OR-145 Lindblad, L.E., Lorenz. R.R., Shepherd, J.T. and Vanhoutte, P.M. Effect of vibration on a canine

cutaneous artery. Am. J. Physiol. 250: H519-H523, 1986.

24

OR-146 Katusic, Z.S., Shepherd, J.T. and Vanhoutte, P.M. Oxytocin causes endothelium-dependent relaxations of canine basilar arteries by activating V1-vasopressinergic receptors. J. Pharmacol. Exp. Ther. 236: 166-170, 1986.

OR-147 Lüscher, T.F. and Vanhoutte, P.M. Endothelium-dependent contractions to acetylcholine in the

aorta of the spontaneously hypertensive rat. Hypertension 8: 344-348, 1986. OR-148 Rubanyi, G.M. and Vanhoutte, P.M. Oxygen-derived free radicals, endothelium and

responsiveness of vascular smooth muscle. Am. J. Physiol. 250: H815-H821, 1986. OR-149 Rubanyi, G.M. and Vanhoutte, P.M. Superoxide anions and hyperoxia inactivate endothelium-

derived relaxing factor(s). Am. J. Physiol. 250: H822-H827, 1986. OR-150 Lüscher, T.F. and Vanhoutte, P.M. Endothelium-dependent responses to platelets and serotonin in

spontaneously hypertensive rats. Hypertension 8: II-55-II-60, 1986. OR-151 Rubanyi, G.M., Romero, J.C. and Vanhoutte, P.M. Flow-induced release of endothelium-derived

relaxing factor. Am. J. Physiol. 250: H1145-H1149, 1986. OR-152 Flavahan, N.A. and Vanhoutte, P.M. Alpha1- and alpha2-adrenoceptors: Response coupling in

canine saphenous and femoral veins. J. Pharmacol. Exp. Ther. 238: 131-138, 1986. OR-153 Flavahan, N.A. and Vanhoutte, P.M. The effect of cooling on alpha1- and alpha2-adrenergic

responses in canine saphenous and femoral veins. J. Pharmacol. Exp. Ther. 238: 139-147, 1986. OR-154 Essandoh, L.K., Houston, D.S., Vanhoutte, P.M. and Shepherd, J.T. Differential effects of lower

body negative pressure on forearm and calf blood flow. J. Appl. Physiol. 61: 994-998, 1986. OR-155 Miller, V.M., Aarhus, L.L. and Vanhoutte, P.M. Modulation of endothelium-dependent responses

by chronic alterations of blood flow. Am. J. Physiol. 251: H520-H527, 1986. OR-156 Katusic, Z.S. and Vanhoutte, P.M. Anoxic contractions in isolated canine cerebral arteries:

Contribution of endothelium-derived factors, metabolites of arachidonic acid, and calcium entry. J. Cardiovasc. Pharmacol. 8: S97-S1O1, 1986.

OR-157 Houston, D.S., Shepherd, J.T. and Vanhoutte, P.M. Aggregating human platelets cause direct

contraction and endothelium-dependent relaxation of isolated canine coronary arteries: role of serotonin, thromboxane A2 and adenine nucleotides. J. Clin. Invest. 78: 539-544, 1986.

OR-158 Miller, V.M. and Vanhoutte, P.M. Endothelium-dependent responses in isolated blood vessels of

lower vertebrates. Blood Vessels 23: 225-235, 1986. OR-159 Daskalopoulos, D.A., Rimele, T.J. Flavahan, N.A. and Vanhoutte, P.M. Flunarizine and alpha-

adrenergic responses in isolated canine saphenous veins. Gener. Pharmacol. 18: 193-196, 1987. OR-160 Edoute, Y., Vanhoutte, P.M. and Shepherd, J.T. Inorganic phosphate inhibits sympathetic

neurotransmission in canine saphenous veins. Am. J. Physiol. 252: H131-H134, 1987. OR-161 Lüscher, T.F., Raij, L. and Vanhoutte, P.M. Endothelium-dependent vascular responses in

normotensive and hypertensive Dahl-rats. Hypertension 9: 157-163, 1987.

25

OR-162 Zander, J.F., Aarhus, L.L., Katusic, Z.S., Rubanyi, G.M. and Vanhoutte, P.M. Effects of

naftidrofuryl on adrenergic nerves, endothelium and smooth muscle in isolated canine blood vessels. J. Pharmac. Exp. Ther. 239: 760-767, 1986.

OR-163 Flavahan, N.A. and Vanhoutte, P.M. Sympathetic purinergic vasoconstriction and

thermosensitivity in a canine cutaneous vein. J. Pharmacol. Exp. Ther. 239: 784-789, 1986. OR-164 Danser, A.H.J., van den Ende, R., Lorenz, R.R., Flavahan, N.A. and Vanhoutte, P.M.

Prejunctional beta1-adrenoceptors inhibit cholinergic transmission in canine bronchi. J. Appl. Physiol. 62: 785-790, 1987.

OR-165 Lüscher, T.F., Rubanyi, G.M., Aarhus, L.L., Edoute, Y. and Vanhoutte, P.M. Serotonin reduces

coronary flow in the isolated heart of the spontaneously hypertensive rat. J. Hypertension 4: S148-S150, 1986.

OR-166 Gisclard, V., Flavahan, N.A. and Vanhoutte, P.M. Alpha-adrenergic responses of blood vessels of

rabbits after ovariectomy and administration of 17 ß-estradiol. J. Pharmacol. Exp. Ther. 140: 466-470, 1987.

OR-167 Flavahan, N.A., Miller, V.M., Aarhus, L.L. and Vanhoutte, P.M. Denervation augments alpha2-

but not alpha1-adrenergic responses in canine saphenous veins. J. Pharmacol. Exp. Ther. 240: 589-593, 1987.

OR-168 Lüscher, T.F., Romero, J.C. and Vanhoutte, P.M. Bioassay of endothelium-derived vasoactive

substances in the aorta of normotensive and spontaneously hypertensive rats. J. Hypertens. 4: S81-S83, 1987.

OR-169 Rubanyi, G.M., McKinney, M. and Vanhoutte, P.M. Biphasic release of endothelium-derived

relaxing factor(s) by acetylcholine from perfused canine femoral arteries. Characterization of muscarinic receptors. J. Pharmacol. Exp. Ther. 240: 802-808, 1987.

OR-170 Flavahan, N.A., Cooke, J.P., Shepherd, J.T. and Vanhoutte, P.M. Human postjunctional alpha1

and alpha2-adrenoceptors: differential distribution in arteries of the limbs. J. Pharmacol. Exp. Ther. 241: 361-365, 1987.

OR-171 Katusic, Z., Shepherd, J.T. and Vanhoutte, P.M. Endothelium-dependent contraction to stretch in

canine basilar arteries. Am. J. Physiol. 21: H671-H673, 1987. OR-172 Shimokawa, H., Lam, J.Y., Chesebro, T., Bowie, J H., Walter, E.J. and Vanhoutte, PM. Effects of

dietary supplementation with cod-liver oil on endothelium-dependent responses in porcine coronary arteries. Circulation 76: 898-905, 1987.

OR-173 O'Rourke, S.T. and Vanhoutte, P.M. Subtypes of muscarinic receptors on adrenergic nerves and

vascular smooth muscle of the canine saphenous vein. J. Pharmacol. Exp. Ther. 241: 64-67, 1987. OR-174 Bentley, M.D., Vanhoutte, V., Schryver, S.M., Romero, J.C. and Vanhoutte, P.M. Contraction of

isolated canine renal arteries induced by the radiocontrast medium, sodium/meglumine diatrizoate. J. Labor. Clin. Med. 109: 595-600, 1987.

26

OR-175 Rubanyi, G.M., Frye, R.L., Holmes, D.R. and Vanhoutte, P.M. Vasoconstrictor activity of coronary sinus plasma from patients with coronary artery disease. J. Am. Coll. Cardiol. 9: 1243-1249, 1987.

OR-176 Houston, D.S., Burnstock, G. and Vanhoutte, P.M. Different P2-purinergic receptor subtypes on

endothelium and smooth muscle in canine blood vessels. J. Pharmacol. Exp. Ther. 241: 501-506, 1987.

OR-177 Shimokawa, H., Aarhus, A.A. and Vanhoutte, P.M. Porcine coronary arteries with regenerated

endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin. Circ. Res. 61: 256-270, 1987.

OR-178 Lüscher, T.F., Cooke, J.P., Houston, D.S., Neves, R.J. and Vanhoutte, P.M. Endothelium-

dependent relaxations in human arteries. Mayo Clin. Proc. 62: 601-606, 1987. OR-179 Rubanyi, G.M. and Vanhoutte, P.M. Heterogeneity of endothelium-dependent responses to

acetylcholine in canine femoral arteries and veins. Blood Vessels 25: 75-81, 1988. OR-180 Félétou, M. and Vanhoutte, P.M. Relaxation of the canine coronary artery to electrical

stimulation: limited role of free radicals. Am. J. Physiol. 253: H884-H889, 1987. OR-181 Lüscher, T.F., Vanhoutte, P.M. and Raij, L. Antihypertensive treatment normalizes decreased

endothelium-dependent relaxations in salt-induced hypertension of the rat. Hypertension 9: III-193/III-197, 1987.

OR-182 Miller, V.M., Reigel, M.M., Hollier, L.H. and Vanhoutte, P.M. Endothelium-dependent responses

in autogenous femoral veins grafted into the arterial circulation of the dog. J. Clin. Invest. 80: 1350-1357, 1987.

OR-183 O'Rourke, S.T., Flavahan, N.A. and Vanhoutte, P.M. Characterization of muscarinic receptors in

canine bronchial smooth muscle. Eur. J. Pharmacol. 140: 117-120, 1987. OR-184 Stuart-Smith, K. and Vanhoutte, P.M. Heterogeneity in the effects of epithelium-removal in the

canine bronchial tree. J. Appl. Physiol. 63: 2510-2515, 1987. OR-185 Félétou, M. and Vanhoutte, P.M. Endothelium-dependent hyperpolarization of canine coronary

smooth muscle. Br. J. Pharmacol. 93: 515-524, 1988. OR-186 Burnett, J.C. Jr., Rubanyi, G.M., Edwards, B.S., Schwab, T.R., Zimmerman, R.S. and Vanhoutte,

P.M. Atrial natriuretic peptide decreases cardiac output independent of coronary vasoconstriction. Proc. Soc. Exp. Biol. and Med. 186: 313-318, 1987.

OR-187 Blaise, G., Sill, J.C., Nugent, M., Van Dyke, R.A. and Vanhoutte, P.M. Isoflurane causes

endothelium-dependent inhibition of contractile responses of canine coronary arteries. Anesthesiology, 67: 513-517, 1987.

OR-188 Rubanyi, G.M. and Vanhoutte, P.M. Nature of endothelium-derived relaxing factor: Are there

two different relaxing mediators? Circ. Res. 61: II61-II67, 1987.

27

OR-189 Gisclard, V., Miller, V. and Vanhoutte, P.M. Effect of 17-Estradiol on endothelium-dependent responses in the rabbit. J. Pharmacol. Exp. THer. 244: 19-22, 1988.

OR-190 Katusic, Z.S., Shepherd, J.T. and Vanhoutte, P.M. Potassium induced endothelium-dependent

rhythmic activity in the canine basilar artery. J. Cardiovasc. Pharm. 12: 37-41, 1988. OR-191 Houston, D.S. and Vanhoutte, P.M. Comparison of serotonergic receptor subtypes on the smooth

muscle and endothelium of the canine coronary artery. J. Pharmacol. Exp. Ther. 244: l- 10, 1988. OR-192 Katusic, Z.S., Shepherd, J.T. and Vanhoutte, P.M. Endothelium-dependent contractions to

calcium ionophore A23187, arachidonic acid and acetylcholine in canine basilar arteries. Stroke 19: 476-479, April 1988.

OR-193 Ruff, F., Zander, J.F., Edoute, Y., Santais, M.C., Flavahan, N.A., Verbeuren, T.J. and Vanhoutte,

P.M. Beta2-adrenergic responses to tulobuterol in airway smooth muscle, vascular smooth muscle and adrenergic nerves. J. Pharmacol. Exp. Ther. 244: 173-180, 1987.

OR-194 Rusch, N.J., Aarhus, L.L., Shepherd, J.T. and Vanhoutte P.M. The effect of cold on adrenergic

neurotransmission in canine saphenous arteries and veins. Proc. Soc. Exper. Biol. Med. 187: 506-512, 1988.

OR-195 Harker, C.T. and Vanhoutte, P.M. Cooling the central ear artery of the rabbit: myogenic and

adrenergic responses. J. Pharmacol. Exp. Ther. 245: 89-93, 1988. OR-196 Kim, P., Sundt Jr., T.M., and Vanhoutte, P.M. Alterations in endothelium-dependent

responsiveness of the canine basilar artery after subarachnoid hemorrhage. J. Neurosurgery 69: 239-246, 1988.

OR-197 Rubanyi, G.M. and Vanhoutte, P.M. Potassium-induced release of endothelium-derived relaxing

factor from canine femoral arteries. Circ. Res. 62: 1098-1103, 1988. OR-198 Cooke, J.P., Shepherd, J.T. and Vanhoutte, P.M. Vasoconstriction induced by ouabain in the

canine coronary artery: contribution of adrenergic and non-adrenergic responses. Cardiovasc. Drugs Therapy. 2: 255-263, 1988.

OR-199 Lüscher, T.F. and Vanhoutte, P.M. Are there interactions between S2-serotonergic and alpha1-

adrenergic receptors in isolated canine arteries? J. Cardiol. Pharmacol. 11: S16-S21, 1988. OR-200 Miller, V.M., Gisclard, V. and Vanhoutte, P.M. Modulation of endothelium-dependent and

vascular smooth muscle responses by estrogens. Phlebology 3: 63-69, 1988. OR-201 Harker, C.T., Marcelon, G. and Vanhoutte, P.M. Temperature, estrogens and contractions of

venous smooth muscle of the rabbit. Phlebology 3: 77-82, 1988. OR-202 Soares-De-Moura, R. and Vanhoutte, P.M. Effect of cooling and warming on the vasodilator

response of the isolated dog saphenous artery to acetylcholine. Brazilian J. Med. Biol. Res. 21:157-159, 1988.

OR-203 Rubanyi, G.M. and Vanhoutte, P.M. Potassium-free solution prevents the action but not the

release of endothelium-derived relaxing factor. Eur. J. Pharm. 145: 351-355, 1988.

28

OR-204 Stuart-Smith, K. and Vanhoutte, P.M. The airway epithelium modulates the responsiveness of

porcine bronchial smooth muscle. J. Appl. Physiol. 65: 721-727, 1988. OR-205 Rubanyi, G.M., Hoeffner, U., Schwartz, A. and Vanhoutte, P.M. Stereoselective effect of

diltiazem on endothelium-dependent relaxations in canine femoral arteries. J. Pharmacol. Exp. Ther. 246: 60-64, 1988.

OR-206 Komori, K., Lorenz, R.R. and Vanhoutte, P.M. Nitric oxide, ACh, and electrical and mechanical

properties of canine arterial smooth muscle. Am. J. Physiol. 255: H207-H212, 1988. OR-207 Shimokawa, H., Kim, P. and Vanhoutte, P.M. Endothelium-dependent relaxation to aggregating

platelets in isolated basilar arteries of control and hypercholesterolemic pigs. Circ. Res. 63: 604-612, 1988.

OR-208 Vidal, M.J., Romero, J.C. and Vanhoutte, P.M. Endothelium-derived relaxing factor inhibits renin

release. Eur. J. Pharmacol. 149: 401, 1988. OR-209 Flavahan, N.A., Slifman, N.R., Gleich, G.J. and Vanhoutte, P.M. Human eosinophil major basic

protein causes hyperreactivity of respiratory smooth muscle: role of the epithelium. Am. Rev. Respir. Dis. 138: 685-688, 1988.

OR-210 Rubanyi, G.M. and Vanhoutte, P M. Polarized release of endothelium-derived relaxing factor(s)

by melittin in canine femoral arteries. In: Vasodilatation, Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium, ed. P.M. Vanhoutte. Raven Press, New York, pp. 489-495, 1988.

OR-211 Miller, V.M. and Vanhoutte, P.M. Enhanced release of endothelium-derived factors by chronic

increases in blood flow. Am. J. Physiol. 255: H446-H451, 1988. OR-212 Iqbal, A. and Vanhoutte, P.M. Flunarizine inhibits endothelium-dependent hypoxic facilitation in

canine coronary arteries through an action on vascular smooth muscle. Br. J. Pharmac. 95: 789-794, 1988.

OR-213 Blaise, G., Iqbal, A. and Vanhoutte, P.M. Inhibitors of cyclooxygenase augment serotonergic

responsiveness in canine coronary arteries. Am. J. Physiol. 255: HI032-1035, 1988. OR-214 Kim, P., Lorenz, R.R., Sundt, T.M. and Vanhoutte, P.M. Release of endothelium-derived relaxing

factor after subarachnoid hemorrhage. J. Neurosurgery 70: 108-114, 1989. OR-215 Stuart-Smith, K. and Vanhoutte, P.M. Arachidonic acid evokes epithelium-dependent relaxations

in canine airways. J. Appl. Physiol. 65: 2170-2180, 1988. OR-216 Shimokawa, H., Flavahan, N.A., Lorenz, R.R. and Vanhoutte, P.M. Prostacyclin releases

endothelium-derived relaxing factor and potentiates its action in porcine coronary artery. Br. J. Pharmacol. 95:1197-1203, 1988.

OR-217 Gao, Y. and Vanhoutte, P.M. Removal of the epithelium potentiates acetylcholine in depolarizing

canine bronchial smooth muscle. J. Appl. Physiol. 65: 2400-2405, 1988.

29

OR-218 Félétou, M., Hoeffner, U. and Vanhoutte, P.M. Endothelium-dependent relaxing factors do not affect the smooth muscle of portal-mesenteric veins. Blood Vessels 26:21-32, 1989.

OR-219 Lüscher, T.F., Diederich, D., Weber, E, Vanhoutte, P.M. and Bühler, F.R. Endothelium-

dependent responses in carotid and renal arteries of normotensive and hypertensive rats. Hypertension 2: 573-578, 1988.

OR-220 Shimokawa, H., Aarhus, L.L. and Vanhoutte, P.M. Dietary omega-3 polyunsaturated fatty acids

augment endothelium-dependent relaxation to bradykinin in porcine coronary microvessels. Br. J. Pharmacol. 95:1191-1196, 1988.

OR-221 Raij, L., Lüscher, T.F. and Vanhoutte, P.M. High potassium diet augments endothelium-

dependent relaxations in the dahl rat. Hypertension 12: 562-567, 1988. OR-222 Hoeffner, U. and Vanhoutte, P.M. The endothelium-dependent relaxation induced by arachidonic

acid in canine blood vessels is due to prostanoid production. J. Vasc. Med. & Biol. 1: 50-54, 1989.

OR-223 Janczewski, P., Boulanger, C., Iqbal, A. and Vanhoutte, P.M. Endothelium-dependent effects of

carteolol. J. Pharmacol. Exp. Ther. 247:590-595, 1988. OR-224 Shimokawa, H. and Vanhoutte, P.M. Dietary cod-liver oil improves endothelium-dependent

responses in hypercholesterolemic and atherosclerotic porcine coronary arteries. Circulation 78: 1421-1430, 1988.

OR-225 Flavahan, N.A., Shimokawa, H, and Vanhoutte, P.M. Pertussis toxin inhibits endothelium-

dependent relaxations to certain agonists in porcine coronary arteries. J. Physiol. 408: 549-560, 1989.

OR-226 Lüscher, T.F., Aarhus, L.L. and Vanhoutte, P.M. Indomethacin improves the impaired

endothelium-dependent relaxations in small mesenteric arteries of the spontaneously hypertensive rat. Am. J. Hypertens. 3: 55-58, 1990.

OR-227 Shimokawa, H. and Vanhoutte, P.M. Dietary omega-3 fatty acids and endothelium-dependent

relaxations in porcine coronary arteries. Am. J. Physiol. 256: H968-H973, 1989. OR-228 Duprez, D.A., Essandoh, L.K., Vanhoutte, P.M. and Shepherd, J.T. Vascular responses in forearm

and calf to contralateral static exercises. J. Appl. Physiol. 66: 669-674, 1989. OR-229 Shimokawa, H. and Vanhoutte, P.M. Impaired endothelium-dependent relaxation to aggregating

platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and in atherosclerosis. Circ. Res. 64: 900-914, 1989.

OR-230 Boulanger, C., Hendrickson, H., Lorenz, R.R. and Vanhoutte, P.M. Release of different relaxing

factors by cultured porcine endothelial cells. Circ. Res. 64: 1070-1078, 1989. OR-231 Hoeffner, U., Boulanger, C. and Vanhoutte, P.M. Proximal and distal dog coronary arteries

respond differently to basal EDRF but not NO. Am. J. Physiol. 256: H828-H831, 1989.

30

OR-232 Hoeffner, U. and Vanhoutte, P.M. Increases in flow reduce the release of endothelium-derived relaxing factor in the aorta of normotensive and spontaneously hypertensive rats. Am. J. Hypertens. 2: 762-767, 1989.

OR-233 Shimokawa, H. and Vanhoutte, P.M. Hypercholesterolemia causes generalized impairment of

endothelium-dependent relaxation to aggregating platelets in porcine arteries. J. Am. Coll. Cardiol. 13:1402-1408, 1989.

OR-234 Harker, C.T. and Vanhoutte, P.M. Cooling and alpha-adrenergic responses in the saphenous vein

of the rabbit. J. Pharmacol. Exp. Ther. 249: 56-60, 1989. OR-235 O'Rourke, S.T. and Vanhoutte, P.M. Differential inhibition by ergonovine of norepinephrine

release in the coronary artery and saphenous vein of the dog. J. Pharmacol. Exp. Ther. 249: 52-55, 1989.

OR-236 Vanhoutte, P.M., Auch-Schwelk, W., Boulanger, C., Janssen, P.A., Katusic, Z.S., Komori-Miller,

V.M., Schini, V.B. and Vidal, M. Does endothelin-1 mediate endothelium-dependent contractions during anoxia? J. Cardiovasc. Pharmacol. 13: 124-128, 1989.

OR-237 Hoeffner, U., Félétou, M., Flavahan, N.A. and Vanhoutte, P.M. Canine arteries release two

different endothelium-derived relaxing factors. Am. J. Physiol. 257: H330-H333, 1989. OR-238 Katusic, Z.S. and Vanhoutte, P.M. Superoxide anion is an endothelium-derived contracting factor.

Am. J. Physiol. 257: H33-H37, 1989. OR-239 Kim, P., Sundt, T.M. Jr. and Vanhoutte, P.M. Alterations of mechanical properties in canine

basilar arteries after subarachnoid hemorrhage. J. Neurosurgery 71: 430-436, 1989. OR-240 Auch-Schwelk, W., Katusic, Z.S. and Vanhoutte, P.M. Contractions to oxygen-derived free

radicals are augmented in aorta of the spontaneously hypertensive rat. Hypertension 13: 859-864, 1989.

OR-241 Katusic, Z.S., Marshall, J.J., Kontos, H.A. and Vanhoutte, P.M. Similar responsiveness of smooth

muscle of the canine basilar artery to EDRF and nitric oxide. Am. J. Physiol. 257: H1235-H1239, 1989.

OR-242 Shimokawa, H., Flavahan, N.A. and Vanhoutte, P.M. Natural Course of the impairment of

endothelium-dependent relaxations after balloon endothelium-removal in porcine coronary arteries. Circ. Res. 65: 740-753, 1989.

OR-243 Komori, K., Shimokawa, H. and Vanhoutte, P.M. Endothelium-dependent relaxations to

aggregating platelets in porcine femoral veins and its modulation by diet. Circulation 80: 401-409, 1989.

OR-244 Komori, K., Shimokawa, H., and Vanhoutte, P.M. Hypercholesterolemia impairs endothelium-

dependent relaxations to aggregating platelets in porcine iliac arteries. J. Vasc. Surg.10: 318-325, Sept. 1989.

31

OR-245 Schini, V.B., Hendrickson, H., Heublein, D.M., Burnett, J.C., Jr., and Vanhoutte, P.M. Thrombin enhances the release of endothelin from cultured porcine aortic endothelial cells. Eur. J. Pharmacol. 165: 333-334, 1989.

OR-246 Miller, V.M., Komori, K., Burnett, J.C., Jr., and Vanhoutte, P.M. Differential sensitivity to

endothelin in canine arteries and veins. Am. J. Physiol. 257: H1127-H1131, 1989. OR-247 Hoeffner, U., Aarhus, L.L., Katusic, Z.S., and Vanhoutte, P.M. Pharmacology of pentoxifylline in

isolated canine arteries and veins. J. Cardiovasc. Pharmacol. 14: 899-907, 1989. OR-248 Gao, Y. and Vanhoutte, P.M. Lowering the P02 induces epithelium-dependent relaxation in

isolated canine bronchi. Am. J. Physiol. 257:C1034-C1037, 1989. OR-249 Shimokawa, H., Flavahan, N.A., Shepherd, J.T., and Vanhoutte, P.M. Endothelium-dependent

inhibition of ergonovine-induced contraction is impaired in porcine coronary arteries with regenerated endothelium. Circulation 80:643-650, 1989.

OR-250 Miller, V.M. and Vanhoutte, P.M. Is nitric oxide the only endothelium-derived relaxing factor in

canine femoral veins? Am. J. Physiol. 257: H1910-H1916, 1989. OR-251 Zellers, T.M. and Vanhoutte, P.M. Heterogeneity of endothelium-dependent and independent

responses among large and small porcine pulmonary arteries. Pulmonary Pharmacol. 2: 201-208, 1989.

OR-252 Schini, V.B., Dewey J. and Vanhoutte, P.M. Effects of indapamide on endothelium-dependent

relaxations in isolated canine femoral arteries. Am. J. Cardiol. 65: 6H-10H, 1990. OR-253 Félétou, M., Harker, C.T., Komori, K., Shepherd, J.T. and Vanhoutte, P.M. Ammonium ions

cause relaxation of isolated canine arteries. J. Pharmacol. Exp. Ther. 251: 82-89, 1989. OR-254 Vedernikov, Y.P., Aarhus, L., Shepherd, J.T. and Vanhoutte, P.M. Postmortem changes in

endothelium-dependent and independent responses of porcine coronary arteries. Gener. Pharmacol. 21: 49-52, 1990.

OR-255 Auch-Schwelk, W. and Vanhoutte, P.M. Endothelium-derived relaxing factor and calcium

antagonists. Z. Kardiol. 78: 1989. OR-256 Félétou, M. and Vanhoutte, P.M. Tetrodotoxin-insensitive relaxation of coronary arterial smooth

muscle to electrical stimulation: possible involvement of a dopaminergic mechanism. Blood Vessels 26: 213-227, 1989.

OR-257 Boulanger, C., Schini, V.B., Hendrickson, H. and Vanhoutte, P.M. Chronic exposure of cultured

endothelial cells to eicosapentaenoic acid potentiates the release of endothelium-derived relaxing factor(s). Br. J. Pharmacol. 99: 176-180, 1990.

OR-258 O'Rourke, S.T. and Vanhoutte, P.M. Celiprolol has no direct or indirect relaxing effects in

isolated arteries and veins. J. Cardiovasc. Pharmacol. 15: 831-835, 1990.

32

OR-259 Komori, K., Flavahan, N.A., Miller, V.M. and Vanhoutte, P.M., Electrophysiological Analysis of Adrenergic Neurotransmission and its Modulation by Chronic Denervation in Canine Saphenous Veins. J. Pharmacol. Exp. Ther. 252: 1197-1201, 1990.

OR-260 Schini, V.B., Boulanger, C., Regoli, D. and Vanhoutte, P.M. Bradykinin stimulates the production

of cyclic GMP via activation of B2 kinin receptors in cultured porcine aortic endothelial cells. J. Pharmacol. Exp. Ther. 252: 581-585, 1990.

OR-261 Flavahan, N.A., and Vanhoutte, P.M. Mechanisms underlying the Inhibitory Interaction between

the Nitrovasodilator SIN-1 and the Endothelium. J. Cardiol. Pharmacol. 14: 86-90, 1990. OR-262 Miller, V.M. and Vanhoutte, P.M. Relaxations to SIN-1, Nitric Oxide and Sodium Nitroprusside

in Canine Arteries and Veins. J. Cardiol. Pharmacol. 14: 67-71, 1990. OR-263 Komori, K, and Vanhoutte, P.M. Effects of SIN-1 ON Electrical Responses of the Smooth Muscle

of the Canine Saphenous Vein. J. Cardiol. Pharmacol. 14: 62-66, 1990. OR-264 Schini, V.B. and Vanhoutte, P.M. SIN-1 Stimulates the Production of Cyclic GMP but not cyclic

AMP in Porcine Aortic Endothelial Cells. J. Cardiovasc. Pharmacol. 14: 91-94, 1990. OR-265 Edoute, M.D., Yeonda, D.S.C., Shepherd, J.T. and Vanhoutte, P.M. Role of Metabolites and

Hyperomolarity in Sympatholysis. J. Vasc. Med. and Biol. 2: 7-11, 1990. OR-266 Morrison, K.J., Flavahan, N.A., and Vanhoutte, P.M. Differential Effects of the Anti-Anginal

Drug Nicorandil on Canine Arteries and Veins. J. Cardiovasc. Pharmacol. 15: 791-798, 1990. OR-267 Scriabine, A., Pan, M., and Vanhoutte, P.M. Effect of Lopoxygenase Inhibitors on Ca2+-Induced

Constriction of the Isolated Rabbit Ear Artery. Gener. Pharmacol. 21: 235-239, 1990. OR-268 Boulanger, S., Flavahan, N.A., Katusic, Z.S., Komori, K., Vos, A.A., and Vanhoutte, P.M.

Effects of CRL 41034 on the Adrenergic Neuroeffector Interaction in the Canine Saphenous Vein. Fund. and Clin. Pharmacol. 4: 525-538, 1990.

OR-269 Pearson, P.J., Schaff, H.V. and Vanhoutte, P.M. Long-term Impairment of Endothelium-

Dependent Relaxations to Aggregating Platelets After Reperfusion Injury in Canine Coronary Arteries. Circulation 81: 1921-1927, 1990.

OR-270 Auch-Schwelk, W., Katusic, Z.S., and Vanhoutte, P.M. Thromboxane A2 Receptor Antagonists

inhibit Endothelium-Dependent Contractions. Hypertension 15: 699-703, 1990. OR-271 Miller, V. and Vanhoutte, P.M. 17ß-Estradiol Augments Endothelium-Dependent Contractions to

Arachidonic Acid in Rabbit Aorta. Am. J. Physiol. 258: R1502-R1507, 1990. OR-272 Katusic, Z.S. and Vanhoutte, P.M. Effects of SIN-1 on Isolated Canine Basilar Arteries. J.

Cardiovasc. Pharmacol. 14: 72-75, 1990. OR-273 Pearson, P.J., Schaff, H.V. and Vanhoutte, P.M. Acute Impairment of Endothelium-Dependent

Relaxations to Aggregating Platelets Following Reperfusion Injury in Canine Coronary Arteries. Circ. Res. 67: 385-393, 1990.

33

OR-274 Komori, K., Gloviczki, P., Bourchier, R.G., Miller, V.M., Vanhoutte, P.M. Endothelium-Dependent Vasorelaxations in Response to Aggregating Platelets are Impaired in Reversed Vein Grafts. J. Vasc. Surg. 12: 139-147, 1990.

OR-275 Biondi, M.L., Dousa, T., Vanhoutte, P.M., and Romero, J. C. Evidences for the Existence of

Endothelium-Derived Relaxing Factor in the Renal Medulla. Am. J. Hypertens. 3: 876-879, 1990. OR-276 Katusic, Z.S., Moncada, S. and Vanhoutte, P.M. Inhibitory Effect of NG-monomethyl-L-arginine

on Endothelium-Dependent Relaxations to Vasopressin. Elsevier Science Publishers, B.V. (Biomedical Division) 8: 69-72, 1990.

OR-277 Schini, V.B., Moncada, S. and Vanhoutte, P.M. NG-monomethyl-L-arginine Inhibits Thrombin-

stimulated Production of Cyclic GMP in Cultured Porcine Aortic Endothelial Cells. Elsevier Science Publishers, B.V. (Biomedical Division) 50: 451-456, 1990.

OR-278 Stuart-Smith, K. and Vanhoutte, P.M. Epithelium, Contractile Tone and Responses to Relaxing

Agonists in Canine Bronchi. J. Appl. Physiol. 69: 678-684, 1990. OR-279 Boulanger C. and Vanhoutte P.M. Ouabain, Na+-free and K+-free Solutions and Relaxations to

Nitric Oxide and Nitrovasodilators. Gener. Pharmacol. 22: 337-340, 1991. OR-280 Error OR-281 O'Rourke, S.T. and Vanhoutte, P.M. Adrenergic and Cholinergic Responsiveness of the Isolated

Canine Bronchial Artery. Am. J. Physiol. 259: H156-H161, 1990. OR-282 Sanchez-Ferrer, C.F., Burnett, Jr., J.C., Lorenz, R.R. and Vanhoutte, P.M. Possible Modulation

of the Release of Atrial Natriuretic Factor by Endothelium-Derived Relaxing Factor. Am. J. Physiol. 259: H982-H986, 1990.

OR-283 Boulanger, C., Schini, V.B., Moncada, S., and Vanhoutte, P.M. Stimulation of Cyclic GMP

Production in Cultured Porcine Endothelial Cells by Bradykinin, Adenosine Diphosphate, Calcium Ionophore A23187 and Nitric Oxide. Br. J. Pharm. 101: 152-156, 1990.

OR-284 Flavahan, N.A. and Vanhoutte, P.M. Pertussis Toxin Inhibits Endothelium-Dependent

Relaxations Evoked by Fluoride. Eur. J. Pharm. 178: 121-124, 1990. OR-285 Eber B., Rowbotham, B., Vanhoutte, P.M. Recombinant Hirudin Inhibits Endothelium-Mediated

Relaxations Evoked by Thrombin in Isolated Canine Coronary Arteries. J Vasc. Med. and Biol. 2: 45-90, 1990.

OR-286 Busk, M.F., Flavahan, N.A., Vanhoutte, P.M. Effects of the methyl xanthine, S9795, on isolated

bronchi of the dog. J. Pharmacol. Exp. Ther. 254: 1045-1053. OR-287 Blaise G.A., Witzeling, T.M., Sill, J.C., Vinay, P. and Vanhoutte, P.M. Fentanyl is devoid of

major effects on coronary vasoreactivity and myocardial metabolism in experimental animals. Anesthesiology 72: 535-541, 1990.

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OR-288 Schini, V.B., Katusic, Z.S. and Vanhoutte, P.M. Neurohypophyseal peptides and tachykinins stimulate the production of cyclic GMP in cultured porcine aortic endothelial cells. J. Pharmacol. Exp. Ther. 255: 994-1000, 1990.

OR-289 Schini, V.B. and Vanhoutte, P.M. L-arginine evokes both endothelium-dependent and

independent relaxations in l-arginine-depleted aortas of the rat. Circ. Res. 68: 209-216, 1991. OR-290 Flavahan, N.A., Shimokawa, H. and Vanhoutte, P.M. Inhibition of endothelium-dependent

relaxations by phorbol myristate acetate in canine coronary arteries. J. Pharmacol. and Exper. Ther. 256: 50-55, 1991.

OR-291 Miller, V.M., Bower, T.C., McCullough, J.L., Gloviczki, P. and Vanhoutte, P.M. Endothelium-

dependent responses in non-reversed (in situ) vein grafts. J. Vasc. Biol. Med. 2: 155-162, 1990. OR-292 Shimokawa, H., Flavahan, N.A. and Vanhoutte, P.M. Loss of endothelial pertussis toxin-sensitive

G-protein function in atherosclerotic porcine coronary arteries. Circulation 83: 652-660, 1991. OR-293 Shimokawa, H. and Vanhoutte, P.M. Angiographic demonstration of hyperconstriction induced

by serotonin and aggregating platelets in porcine coronary arteries with regenerated endothelium. J. Am. Coll. Cardiol. 17: 1197-1202, 1991.

OR-294 Nagao, T. and Vanhoutte, P.M. Hyperpolarization as a mechanism for endothelium-dependent

relaxations in the porcine coronary artery. J. Physiol. 445: 355-367, 1992. OR-295 Auch-Schwelk, W. and Vanhoutte, P.M. Calcium antagonists inhibit contractions to

norepinephrine in the rat aorta, in the absence, but not in the presence of the endothelium. Gener. Pharmacol. 22: 595-602, 1991.

OR-296 Vidal, M., Vanhoutte, P.M., and Miller, V.M. Dissociation between endothelium-dependent

relaxations and increases in cyclic GMP in systemic veins. Am. J. Physiol. 260: H1531-H1537, 1991.

OR-297 Komori, K., Schini, V.B., Gloviczki, P., Bourchier, R.G. and Vanhoutte, P.M. The impairment of

endothelium-dependent relaxations in reversed vein grafts is associated with a reduced production of cyclic GMP. J. Vasc. Surg. 14: 67-75, 1991.

OR-298 Scott-Burden, T., Resink, T.J., Hahn, A.W.A and Vanhoutte, P.M. Induction of endothelin

secretion by angiotensin II: Effects on growth and synthetic activity of vascular smooth muscle cells. J. Cardiovasc. Pharmacol. 17: S96-S100, 1991.

OR-299 Schini, V.B., Kim, N.D. and Vanhoutte, P.M. The basal and stimulated release of EDRF inhibits

the contractions evoked by endothelin-1 and endothelin-3 in aortae of normotensive and spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 17: S266-S270, 1991.

OR-300 Miller, V.M., Flavahan, N.A. and Vanhoutte, P.M. Pertussis toxin reduces endothelium-

dependent and independent responses to alpha2-adrenergic stimulation in systemic canine arteries and veins. J Pharmacol Exp. Ther. 257: 290-293, 1991.

35

OR-301 Miller, V.M., Marcelon, G. and Vanhoutte, P.M. Ruscus extract releases endothelium-derived relaxing factor in arteries and veins; In: Return Circulation and Norepinephrine: An Update, ed. Vanhoutte P.M. J. Libbey, Paris, pp. 31-42, 1991.

OR-302 Tuncer, M. and Vanhoutte, P.M. Role of prostanoids in the increased vascular responsiveness and

delayed tachyphylaxis to serotonin in the kidney of the spontaneously hypertensive rats. J. Hypertens. 9: 623-629, 1991. OR-303 Scott-Burden, T., Mackie, E.J. and Vanhoutte, P.M. Angiotensin and vascular structure:

modulation of extracellular matrix synthesis in cultured smooth muscle cells. In: Current Advances in Ace Inhibition II, eds. G.A. MacGregor and P.S. Sever, Churchhill Livingston, Edinburgh, pp 134-136, 1991.

OR-304 Gao, Y., Nagao, T., Bond, R.A., Janssens, W.J. and Vanhoutte, P.M. Nebivolol Induces

Endothelium-Dependent Relaxations of Canine Coronary Arteries. J. Cardiovasc. Pharmacol. 17: 964-969, 1991.

OR-305 Eber, B., Auch-Schwelk, W., Biondi, M-L., Vanhoutte, P.M. IgM-Anticardiolipin-antibodies

evoke endothelium-independent relaxations in isolated canine coronary arteries. J. Vasc. Med. Biol. 2: 275-280, 1990.

OR-306 Zellers, T.M., Shimokawa, H., Yunginger, J. and Vanhoutte, P.M. Heterogeneity of Endothelium-

Dependent and Endothelium-Independent Responses to Aggregating Platelets in Porcine Pulmonary Arteries. Circ. Res. 68: 1437-1445, 1991.

OR-307 Nilsson, F.N., Miller, V.M., Vanhoutte, P.M., McGregor, C.G.A. Methods of Cardiac

Preservation Alter the Function of the Endothelium and Vascular Smooth Muscle in Porcine Coronary Arteries. J. Thorac. Cardiovasc. Surg. 102: 923-930, 1991.

OR-308 Kerth, P.A. and Vanhoutte, P.M. Effects of Perindoprilat on Endothelium-Dependent Relaxations

and Contractions in Isolated Blood Vessels. Am. J. Hypertens. 4: 226S-234S, 1991. OR-309 Schini, V.B. and Vanhoutte, P.M. L-Arginine Evokes Relaxations of the Rat Aorta in Both the

Presence and Absence of Endothelial Cells. J. Cardiovasc. Pharmacol. 17: S10-S14, 1991. OR-310 Schini, V.B., Junquero, D.C., Scott-Burden, T. and Vanhoutte, P.M. Interleukin-1ß induces the

production of an L-Arginine-derived relaxing factor from cultured smooth muscle cells from rat aorta. Biochem. Biophys. Res. Comm. 176: 114-121, 1991.

OR-311 Klein, W., Eber, B., Dusleag, J., Rotman, B., Koeltringer, P., Luha, O. and Vanhoutte, P.M.

Ketanserin prevents early restenosis following percutaneous transluminal coronary angioplasty. Clin. Physiol. Bioch. 8: 101-107, 1990.

OR-312 Vilaine, J-P., Biondi, M.L., Villeneuve, N., Félétou, M., Peglion, J-L and Vanhoutte, P.M. The

calcium channel antagonist S 11568 causes endothelium-dependent relaxation in canine arteries. Eur. J. Pharmacol. 197: 41-48, 1991.

OR-313 Nagao, T. and Vanhoutte, P.M. Membrane hyperpolarization contributes to endothelium-

dependent relaxations induced by acetylcholine in the femoral vein of the rat. Am. J. Physiol. 261: H1034-H1037, 1991.

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OR-314 Miller, V.M. and Vanhoutte, P.M. Progesterone and modulation of endothelium-dependent

responses in canine coronary arteries. Am. J. Physiol. 261: R1022-R1027, 1991. OR-315 Mombouli, J-V., Nephtali, M. and Vanhoutte, P.M. Effects of the Converting Enzyme Inhibitor

Cilazaprilat on Endothelium-Dependent Responses. Hypertension 18: II-22-II-29, 1991. OR-316 Auch-Schwelk, W. and Vanhoutte, P.M. Endothelium-Derived Contracting Factor Released by

Serotonin in the Aorta of the SHR. Am. J. Hypertens. 4: 769-772, 1991. OR-317 Morrison, K.J. and Vanhoutte, P.M. Inhibition of Airway Smooth Muscle Tone by a Phorbol

Ester in the Guinea-Pig Trachea: Role of Epithelium and Receptor Reserve of the Contractile Agent. J. Pharmacol. Exp. Ther. 259: 198-204, 1991.

OR-318 Durante, W. Schini, V.B., Scott-Burden, T., Junquero, D.C., Kroll, M.H., Vanhoutte, P.M. and

Schafer, A.I. Inhibition of Platelet Activation by an L-Arginine Derived Substance Released by Cultured Vascular Smooth Muscle Cells Treated with Interleukin-1ß. Am. J. Physiol. 261: H2024-H2030, 1991.

OR-319 Nilsson, F.N., Miller, V.M., Vanhoutte, P.M., McGregor, C.G.A. Methods of Cardiac

Preservation Alter the Function of the Endothelium in Porcine Coronary Arteries. J. Thor. Card. Surg. 102: 923-930, 1991

OR-320 Gräser, T. and Vanhoutte, P.M. Hypoxic contraction of canine coronary arteries: role of

endothelium and cGMP. Am. J. Physiol. 261: H1769-H1777, 1991. OR-321 Junquero, D.C., Schini, V.B. and Vanhoutte, P.M. Indapamide potentiates the endothelium-

dependent production of cyclic guanosine monophosphate by bradykinin in the canine femoral artery. Am. Heart J. 122: 1204-1209, 1991.

OR-322 Rubanyi, G. Iqbal, A., Schwartz, A. and Vanhoutte, P.M. Vascular Actions of TA 3090, a Novel

Analogue of Diltiazem: Interaction with Endothelium-dependent Relaxation in Canine Femoral and Coronary Arteries. J. Pharmacol. Exp. Ther. 255: 639-642, 1991.

OR-323 Rogers, P.J., Miller, T.D., Bauer, B.A., Brum, J.M., Bove, A.A., Vanhoutte, P.M. Exercise

Training and Responsiveness of Isolated Coronary Arteries. J. Appl. Physiol. 71: 2346-2351, 1991.

OR-324 Boulanger, C.M. and Vanhoutte, P.M. Cholera Toxin augments the release of endothelium-

derived relaxing factor evoked by bradykinin and the calcium ionophore A23187. Gener. Pharmacol. 23: 27-31, 1992.

OR-325 Bond, R.A. and Vanhoutte, P.M. Interaction of tertatolol at the "Atypical" or Beta3-Adrenoceptor

in guinea-pig ileum. Gener. Pharmacol. 23: 171-176, 1992. OR-326 Dean, M.T., Wood, M.B. and Vanhoutte, P.M. Antagonist Drugs and Bone Vascular Smooth

Muscle. J. Orth. Res. 10: 149-155, 1992.

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OR-327 Davis, T.R.C., Wood, M.B. and Vanhoutte, P.M. The Effect of Hypothermic Ischemia on the Alpha-Adrenergic Mechanisms of Long Bone Resistance Vessels. J. Orth. Res. 10: 104-111, 1992.

OR-328 Zhonge, Y., Wood, M.B. and Vanhoutte, P.M. Alpha-adrenergic Receptor Responsiveness in

Vascular Smooth Muscle of Canine Bone. Clin. Orth. Related Res. 287: 286-291, 1993. OR-329 Zellers, T.M. and Vanhoutte, P.M. Endothelium-dependent relaxations of piglet pulmonary

arteries augment with maturation. Ped. Res. 30: 176-180, 1991. OR-330 Kim, P., Schini, V.B., Sundt, Jr., T.M. and Vanhoutte, P.M. Reduced production of cyclic GMP

underlies the loss of endothelium-dependent relaxations in the canine basilar artery after subarachnoid hemorrhage. Circ. Res. 70: 248-256, 1992.

OR-331 Miller, V.M., Marcelon, G. and Vanhoutte, P.M. Progesterone augments the venoconstrictor

effect of Ruscus without altering adrenergic reactivity. Phlebology 6: 261-268, 1991. OR-332 Kim, P.M, Shimokawa, H. and Vanhoutte, P.M. Dietary -3 fatty acids and endothelium-

dependent responses in porcine cerebral arteries. Stroke 3: 407-413, 1992. OR-333 Mombouli, J-V. and Vanhoutte, P.M. Kinins and Endothelium-dependent relaxations to

converting enzyme inhibitors in perfused canine arteries. J. Cardiovasc. Pharmacol. 18: 926-927, 1991.

OR-334 Schini, V.B. and Vanhoutte, P.M. Inhibitors of calmodulin impair the constitutive but not the

inducible nitric oxide synthase activity in the rat aorta. J. Pharmacol. Exp. Ther. 261: 553-559, 1992.

OR-335 Auch-Schwelk, W., Katusic, Z.S. and Vanhoutte, P.M. Nitric oxide inactivates endothelium-

derived contracting factor in the rat aorta. Hypertension 19: 442-445, 1992. OR-336 Durante, W., Kroll, M.H., Vanhoutte, P.M. and Schafer, A.I. Endothelium-derived relaxing factor

inhibits thrombin-induced platelet aggregation by inhibiting platelet phospholipase C. Blood 79: 110-116, 1992.

OR-337 Scott-Burden, T., Mackie, E.J., Bühler, F.R. and Vanhoutte, P.M. Angiotensin II Induction of

Smooth Muscle Extracellular Matrix Synthesis in Culture. J. Vasc. Med. Biol. 3: 271-276, 1992. OR-338 Guo, H., G., Lorenz, R.R. and Vanhoutte, P.M. Anisodamine Inhibits non-selectively muscarinic

receptors in isolated canine veins. Chinese Med. J. 105: 5-10, 1992. OR-339 Junquero, D.C., Schini, V.B., Scott-Burden, T. and Vanhoutte, P.M. Transforming growth factor-

ß-1 inhibits L-arginine derived relaxing factor(s) from smooth muscle cells. Am. J. Physiol. 262: H1788-H1795, 1992.

OR-340 Hoshino, Y., Verbeuren, T.J., Hughes, H. and Vanhoutte, P.M. Effects of S14001 on Adrenergic

Neuroeffector Interaction in Isolated Canine Saphenous Veins. Gener. Pharmacol. 23: 867-872, 1992.

OR-341 Mombouli, J-V., Illiano, S., Nagao, T., Scott-Burden, T. and Vanhoutte, P.M. The Potentiation of

endothelium-dependent relaxations to bradykinin by angiotensin I converting enzyme inhibtors in

38

the canine coronary artery involves both endothelium-derived relaxing and hyperpolarizing factors. Circ. Res. 71: 137-144, 1992.

OR-342 Morrison, K.J. and Vanhoutte, P.M. Characterization of muscarinic receptors that mediate

contractions of guinea-pig isolated trachea to choline esters: Effect of removing epithelium. Br. J. Pharmacol. 106: 672-676, 1992.

OR-343 Joly, G.A., Schini, V.B. and Vanhoutte, P.M. Balloon injury and interleukin-1ß induce nitric

oxide synthase activity in rat carotid arteries. Circ. Res. 71: 331-338, 1992. OR-344 Schini, V.B., Durante, W., Elizondo, E., Scott-Burden, T., Junquero, D.C., Schafer, A.I. and

Vanhoutte, P.M. The induction of nitric oxide synthase activity is inhibited by TGF-ß1, PDGFAB and PDGFBB in vascular smooth muscle cells. Eur. J. Pharmacol. 216: 379-383, 1992.

OR-345 Auch-Schwelk, W. and Vanhoutte, P.M. Contractions to endothelin in normotensive and

spontaneously hypertensive rats: role of endothelium and prostaglandins. Blood Pressure 1: 45-49, 1992.

OR-346 Gao, Y. and Vanhoutte, P.M. Effects of hydrogen peroxide on the responsiveness of isolated

canine bronchi: role of prostaglandin E2 and I2. Am. J. Physiol. 263: L402-L408, 1992. OR-347 Mombouli, J.-V. and Vanhoutte, P.M. Kinins mediate Kallikrein-induced endothelium-dependent

relaxations in isolated canine coronary arteries. Biomed. Biophys. Res. Comm. 185: 693-697, 1992.

OR-348 Nagao, T., Illiano, S. and Vanhoutte, P.M. Heterogeneous distribution of endothelium-dependent

relaxations resistant to nitro-L-arginine in the arterial tree of the rat. Am. J. Physiol. 263: 1090-1094, 1992.

OR-349 Junquero, D.C., Scott-Burden, T., Schini, V.B. and Vanhoutte, P.M. Inhibition of interleukin-1ß-

induced nitric oxide production by transforming growth factor-ß1 in human aortic smooth muscle cells. J. Physiol. 454: 451-465, 1992.

OR-350 Illiano, S.C., Nagao, T. and Vanhoutte, P.M. Calmidazolium, a calmodulin inhibitor, inhibits

endothelium-dependent relaxations resistant to nitro-L-arginine in the canine coronary artery. Br. J. Pharmacol. 107: 387-392, 1992.

OR-351 Scott-Burden, T., Schini, V.B., Elizondo, E., Junquero, D.C. and Vanhoutte, P.M. Platelet-derived

growth factor suppresses, whereas fibroblast growth factor enhances cytokine-induced production of nitric oxide by cultured smooth muscle cells: Effects on cell proliferation. Circ. Res. 71: 1088-1100, 1992.

OR-352 Junquero, D.C., Scott-Burden, T., Schini, V.B., Durante, W., Schafer, A.I. and Vanhoutte, P.M.

Induction of nitric oxide production in human vascular smooth muscle cells by interleukin-1ß and its inhibition by transforming growth factor-ß. In: Biology of Nitric Oxide, eds. Moncada, S., Marletta, M.A., Hibbs, J.B., and Higgs, E.A. Portland Press Proceedings, London, pp. 336-341, 1992.

OR-353 Illiano, S.C., Nagao, T. and Vanhoutte, P.M. Effect of calmodulin inhibitors on endothelium-

dependent relaxations in response to bradykinin in porcine and canine coronary arteries. In:

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Biology of Nitric Oxide eds. Moncada, S., Marletta, M.A., Hibbs, J.B., and Higgs, E.A. Portland Press Proceedings, London, pp. 93-97, 1992.

OR-354 Nagao, T., Illiano, S.C. and Vanhoutte, P.M. Calmodulin antagonists inhibit endothelium-

dependent hyperpolarization in the canine coronary artery. Br. J. Pharmacol. 107:382-386, 1992. OR-355 Gao, Y., and Vanhoutte, P.M. Hypotonic solutions induce epithelium-dependent relaxation of

isolated canine bronchi. Lung 170: 339-347, 1992. OR-356 Guo, H., G., Lorenz R.R., Vanhoutte, P.M. Anisodamine antagonizes acetylcholine-induced

inhibition of adrenergic neurotransmission in the canine saphenous vein. Chinese Med. Sci. J. 7: 32-35, 1992.

OR-357 Error OR-358 Mombouli, J.V., and Vanhoutte, P.M. Heterogeneity of endothelium-dependent vasodilator

effects of angiotensin-converting enzyme-inhibitors: Role of bradykinin generation during ACE inhibition. J. Cardiovasc. Pharmacol. 20: S74-S82, 1992.

OR-359 Guo, H., Lorenz, R.R., and Vanhoutte, P.M. Anisodamine inhibits acetylcholine-induced

endothelium-dependent relaxation of canine femoral artery. Chin. Med. J. 105: 666-670, 1992. OR-360 Nagao, T., and Vanhoutte, P.M. Characterization of endothelium-dependent relaxations resistant

to nitro-L-arginine in the porcine coronary artery. Br. J. Pharmacol. 107: 1102-1107, 1992. OR-361 Shibano, T., and Vanhoutte, P.M. Induction of NO production by TNF- and LPS in porcine

coronary arteries without endothelium. Am. J. Physiol. 264: H403-H407, 1993. OR-362 Boulanger, C.M., Hughes, H., Bond, R.A., Rafla, E., and Vanhoutte, P.M. Effects of S9977 on

adrenergic neurotransmission. Gener. Pharmacol. 24: 429-434, 1993. OR-363 Taddei, S., Vanhoutte, P.M. Role of endothelium in endothelin-evoked contractions in the rat

aorta. Hypertension 21: 9-15, 1993. OR-364 Boulanger, C.M., and Vanhoutte, P.M. Interleukin-2 causes endothelium-dependent contractions

to arachidonic acid. Hypertension 21: 289-293, 1993. OR-365 Schini, V.B., Catovsky, S., Durante, W., Scott-Burden, T., Schafer, A.I. and Vanhoutte, P.M.

Thrombin inhibits the induction of nitric oxide synthase in vascular smooth muscle cells. Am. J. Physiol. 264: H611-H616, 1993.

OR-366 Katusic, Z., Schugel, J., Cosentino, F., and Vanhoutte, P.M. Endothelium-Dependent Contractions to Oxygen-Derived Free Radicals in the Canine Basilar

Artery. Am. J. Physiol. 264: H859-H864, 1993. OR-367 Shibano, T., Codina, J., Birnbaumer, L., and Vanhoutte, P.M. Guanosine 5'-O-(3-

thiotriphosphate) causes endothelium-dependent, pertussis toxin-sensitive relaxations in porcine coronary arteries. Biochem. Biophys. Res. Comm. 189: 324-9, 1992.

40

OR-368 Schini, V., Catovsky, S., Scott-Burden, T., and Vanhoutte, P.M. The Inducible Nitric Oxide Synthase is Impaired by Thrombin in Vascular Smooth Muscle Cells. J. Pharmac. Cardiovasc. 20: 142-144, 1992.

OR-369 Joly, G., Schini, V.B., and Vanhoutte, P.M. Balloon Injury Induces Nitric Oxide Synthase

Activity in Rat Carotid Arteries J. Cardiovasc. Pharmacol. 20: 151-154, 1992. OR-370 Schini, V.B., Durante, W., Scott-Burden, T., Junquero, D.C., Schager, A., I. and Vanhoutte, P.M.

The induction of nitric oxide synthase activity in cultured vascular smooth muscle cells exposed to transforming growth factor-ß and platelet-derived growth factor families. In: Biology of Nitric Oxide, eds. Moncada, S., Marletta, M.A., Hibbs, J.B., and Higgs, E.A. Portland Press Proceedings, London, pp. 93-97, 1992.

OR-371 Scott-Burden, T., Schini, V.B., and Vanhoutte, P.M. Induction by interleukin-1ß of nitric oxide

synthase leads to inhibition of mitogen-stimulated DNA synthesis in cultured vascular smooth muscle cells. In: Biology of Nitric Oxide, eds. Moncada, S., Marletta, M.A., Hibbs, J.B., and Higgs, E.A. Portland Press Proceedings, London, pp. 48-52, 1992.

OR-372 Gao, Y. and Vanhoutte, P.M. Respiratory epithelium modulates the responses of canine bronchi

to cooling. J. Appl. Physiol. 75: 2421-2425, 1993. OR-373 Gao, Y., and Vanhoutte, P.M. Products of cyclooxygenase mediate the responses of the guinea-

pig trachea to hydrogen peroxide. J. Appl. Physiol. 74: 2105-2111, 1993. OR-374 Nagao, T., and Vanhoutte, P.M. Electrical and mechanical changes during anoxic contractions of

the isolated canine basilar artery. J. Cerebr.l Blood Flow and Metabolism 13: 498-502, 1993. OR-375 Junquero, D.C., Scott-Burden, T., Schini, V. and Vanhoutte, P.M. The production of nitric oxide

evoked by interleukin-1ß in cultured aortic smooth muscle cells from spontaneoulsy hypertensive rats is greater than that from normotensive rats. In: Genetic Hypertension, eds. J. Sassard, Colloque INSERM/ John Libbey Eurotext Ltd., 218: pp. 3-5, 1992.

OR-376 Mombouli, J.V., Illiano, S., and Vanhoutte, P.M. Local Production of Kinins contributes to the

endothelium dependent-relaxations evoked by converting enzyme inhibitors in isolated arteries. Agents and Actions 38: 186-195, 1992.

OR-377 Guo, Heng-Yi, Lorenz, R., Verbeuren, T., Vanhoutte, P.M. Effects of S-11701 on accumulation,

release and metabolism of norepinephrine in isolated canine saphenous veins. Gener. Pharmacol. 23: 1079-1085, 1992.

OR-378 Schini, V.B., Durante, W., Catovsky, S., and Vanhoutte, P.M. Eicosapentaenoic acid potentiates

the production of nitric oxide evoked by interleukin-1 in cultured vascular smooth muscle cells. J. Vasc. Res. 30: 209-217, 1993.

OR-379 Schini, V.B., Catovsky, S., Busse, R., and Vanhoutte, P.M. Insulin-like growth factor-I inhibits

induction of nitric oxide synthase in vascular smooth muscle cells. Circ. Res. 74: 24-32, 1994. OR-380 Junquero, D.C., Schini, V.B., Scott-Burden, T., and Vanhoutte, P.M. Enhanced production of

nitric oxide in aortas from spontaneously hypertensive rats by interleukin-1. Am. J. Hypertens. 6:602-610, 1993.

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OR-381 Durante, W., Schini, V.B., Catowsky, S., Kroll, M.H., and Vanhoutte, P.M., and Schaffer, A.I.

Plasmin potentiates induction of nitric oxide synthesis by interleukin-1 in vascular smooth muscle cells. Am. J. Physiol. 264: H617-H624, 1993.

OR-382 Tuncer, M., and Vanhoutte, P.M. Serotonin releases a vasoconstrictor prostanoid in the kidney of

the aging spontaneously hypertensive rat. Blood Pressure 2: 142-145, 1993. OR-383 Tuncer, M., and Vanhoutte, P.M. Response to the Endothelium-Dependent Vasodilator

Acetylcholine in Perfused Kidneys of Normotensive and Spontaneously Hypertensive Rats. Blood Pressure 2: 217-220, 1993.

OR-384 Boulanger, C.M., Desta, B., Clozel, J.P., and Vanhoutte, P.M. Chronic treatment with the Ca2+

channel inhibitor RO 40-5967 potentiates endothelium-dependent relaxations in the aorta of the hypertensive salt sensitive dahl rat. Blood Pressure, 3: 193-196, 1994.

OR-385 Gao, Y., and Vanhoutte, P.M. Attenuation of contractions to aceytylcholine in canine bronchi by

an endogenous nitric oxide-like substance. Br. J. Pharmacol. 109: 887-891, 1993. OR-386 Boulanger, C.M., Mombouli, J.V., and Vanhoutte, P.M. Indapamide inhibits endothelium-

dependent contractions in the aorta of the spontaneously hypertensive rat. Fundam. Clin. Pharmacol. 7: 443-448, 1993.

OR-387 Nakashima, M., and Vanhoutte, P.M. Endothelin-1 and endothelin-3 cause endothelium-

dependent hyperpolarization in the rat mesenteric artery. Am. J. Physiol. 265: H2137-H2141, 1993.

OR-388 Gao, Y., Vanhoutte, P.M. Responsiveness of the guinea-pig trachea to stretch: role of the

epithelium and of products of cyclooxygenase. J. Appl. Physiol. 75: 2112-2116, 1993. OR-389 Mombouli, J.V., Vanhoutte, P.M. Purinergic Endothelium-Dependent and Independent

Contractions in Rat Aorta. Hypertension 22: 577-583, 1993. OR-390 Nakashima, M., Mombouli, J.V., Taylor A.A., and Vanhoutte, P.M. Endothelium-dependent

hyperpolarization caused by bradykinin in human coronary arteries. J. Clin. Invest. 92: 2867-2871, 1993.

OR-391 Vedernikov, Y.P., Goto, K., and Vanhoutte, P.M. The ETA Antagonist BQ-123 Inhibits Anoxic

Contractions of Canine Coronary Arteries Without Endothelium. J. Cardiovasc. Pharmacol, 22: S252-S256,1993.

OR-392 Nakashima, M., and Vanhoutte, P.M. Endothelins and Membrane Potential of Vascular Smooth

Muscle of the Canine Coronary Artery. J. Cardiovasc. Pharmacol. 22: S229-S231,1993. OR-393 Mombouli, J.V., Lee, S.Q., Wasserstrum, N., and Vanhoutte, P.M. Endothelins 1 and 3 and Big-

endothelin-1 Contract Isolated Human Placental Veins. J. Cardiovasc. Pharmacol. 22: S278-S281, 1993.

OR-394 Nakashima, M., and Vanhoutte, P.M. Age-Dependent Decrease in Endothelium-Dependent

Hyperpolarizations to Endothelin-3 in the Rat Mesenteric Artery. J. Cardiovasc. Pharmacol. 22: S352-S354, 1993.

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OR-395 Taddei, S., and Vanhoutte, P.M. Endothelium-Dependent Contractions to Endothelin in the Rat

Aorta are mediated by Thromboxane A2. J. Cardiovasc. Pharmacol. 22: S328-S331, 1993. OR-396 Schini, V.B., Bond, R., Gao, Y., Illiano, S., Junquero, D., Mombouli, J.V., Nagao, T., Smart, F.,

and Vanhoutte, P.M. The Sydnonimine, C87-3754, Evokes Endothelium-Independent Relaxations and Prevents Endothelium-Dependent Contractions in Blood Vessels of the Dog. J. Cardiovasc. Pharmacol. 22: S10-S16, 1993.

OR-397 Guo, H., Lorenz, R.R., and Vanhoutte, P.M. Anisodamine at higher concentrations is inhibiting

alpha-adrenergic responses in isolated canine blood vessels. Chinese Med. J. 106: 452-457, 1993. OR-398 Park, S.J., Boulanger, C.M., Kirchengast, M., and Vanhoutte, P.M. Effects of the Combined 5-

hydroxytryptaMine2 receptor and Ca2+ channel antagonist LU49938 on the Responsiveness of Isolated Porcine Coronary Arteries With and Without Endothelium. J. Cardiovasc. Pharmacol. 24: 517-522, 1994.

OR-399 Le, S.Q., Wasserstrum, N., Mombouli, J.V., and Vanhoutte, P.M. Contractile effect of endothelin

in human placental veins: Role of endothelium prostaglandins and thromboxane. Am. J. Obstet Gynecol. 169: 919-924, 1993.

OR-400 Durante, W., Schini, V.B., Kroll, M.H., Catovsky, S., Scott-Burden, S., White, J.G., Vanhoutte,

P.M., and Schafer, A.E. Platelets inhibit the induction of nitric oxide synthesis by interleukin-1 in vascular smooth muscle cells. Blood, 83: 1831-1838, 1994.

OR-401 Scott-Burden, T., Elizondo, E., Ge, T., Boulanger, C.M., and Vanhoutte, P.M. Growth factor

regulation of interleukin-1 induced nitric oxide synthase and GTP : cyclohydrolase expression in cultured smooth muscle cells. Biochem. Biophys. Res. Comm. 196: 1261-1266, 1993.

OR-402 Boulanger, C.M., Nakashima, M., Olmos, O., Joly, G., and Vanhoutte, P.M. Effect of the Ca2+

antagonist RO 40-5967 on enothelium-dependent responses of isolated arteries. J. Cardiovasc. Pharmacol. 23: 869-876, 1994.

OR-403 Gao, Y., and Vanhoutte, P.M. Epithelium acts as a modulator and a diffusion barrier in the

responses of canine airway smooth muscle. J. Appl. Physiol. 76: 1843-1847, 1994. OR-404 Shibano, T., and Vanhoutte, P.M. Involvement of 5-HT2 receptors in chronic endothelial

dysfunction after balloon injury of porcine coronary arteries. Circulation 89: 1776-1785, 1994. OR-405 Hoshino, Y., Morrison, K.J., and Vanhoutte, P.M. Mechanisms of hypoxic vasoconstriction in the

canine isolated pulmonary artery : role of endothelium and sodium pump. Am. J. Physiol. 267: L120-L127, 1994.

OR-406 Boulanger, C.M., Morrison, K.J., and Vanhoutte, P.M. M3-Muscarinic receptors mediate both

endothelium-dependent contraction and relaxation to acetylcholine in the aorta of the spontaneously hypertensive rat. Br. J. Pharmacol. 112: 519-524, 1994.

OR-407 Illiano, S., Mombouli, J.V., Nagao, T., and Vanhoutte, P.M. Potentiation by trandolaprilat of the

endothelium-dependent hyperpolarization induced by bradykinin, J. Cardiovasc. Pharmacol. 23: S6-S10, 1994.

43

OR-408 Vidal, M., Joly, G., Mombouli, J.V., Boulanger, C.M., and Vanhoutte, P.M. The endothelium and vascular effects of the ACE inhibitor trandolaprilat, J. Cardiovasc. Pharmacol. 23: S1-S5, 1994.

OR-409 Shibano, T., Codina, J., Birnbaumer, L., and Vanhoutte, P.M. Pertussis toxin-sensitive G-proteins

in regenerated endothelial cells after balloon denudation of porcine coronary artery. Am. J. Physiol. 267: H979-H981, 1994.

OR-410 Scott-Burden, T., Elizondo, E., Ge, T., Boulanger, C.M., and Vanhoutte, P.M. Simultaneous

activation of adenylyl cyclase and protein kinase C induces production of nitric oxide by vascular smooth muscle cells. Mol. Pharmacol. 46: 274-282, 1994.

OR-411 Belfort, M.A., Saade, G.R., Moise, K.J., Kirshon, B., and Vanhoutte, P.M. Magnesium sulfate and

diphenylhydantoin relax canine middle cerebral artery contracted with the thromboxane-A2 analogue U46619 by different mechanisms: implications for the management of eclampsia. Hypertension in Pregnancy 13: 51-64, 1994.

OR-412 Olmos, L., Mombouli, J.V., Illiano, S., and Vanhoutte, P.M. cGMP mediates the desensitization

to bradykinin in isolated canine coronary arteries. Am. J. Physiol. 268: H865-H870, 1995. OR-413 Park, S.J., Lee, J.J., Kirchengast, M., Boulanger, C.M., and Vanhoutte, P.M. The combined 5-

hydroxytryptamine2 receptor and Ca2+ channel inhibitor LU49938 Restores endothelium-dependent responses in the regenerated endothelium of the porcine coronary artery. Cardiovasc. Res. 29: 95-101, 1995.

OR-414 Weigert, A.L., Schini, V.B., and Vanhoutte, P.M. Endothelium dependent potentiation of the

relaxation of the rat aorta to isoproterenol. Role of inhibition of cyclic AMP phosphodiesterase by cyclic GMP. Life Sciences Advances 13: 45-52, 1994.

OR-415 Nakashima, M. and Vanhoutte, P.M. Isoproterenol causes hyperpolarization through opening of

ATP-sensitive potassium channels in vascular smooth muscle of the canine saphenous vein. J. Pharmacol. Exp. Ther. 272: 379-384, 1995.

OR-416 De Castro, M., Mota-Filipe, H., Caneira, M., Giao-T. Rico, J.M., Scott-Burden, T., Vanhoutte,

P.M. DL-Propranolol augments production of NO induced by cytokines in cultured aortic smooth muscle of the rat. Europ. J. Pharmacol. 1-5, 1994.

OR-417 Desta, B., Nakashima, M., Kirchengast, M., Vanhoutte, P.M., and Boulanger, C.M. Previous

exposure to bradykinin unmasks an endothelium-dependent relaxation to the converting enzyme inhibitor trandolaprilat in isolated canine coronary arteries. J. Pharmacol. Exp. Ther. 272: 885-891, 1995.

OR-418 Le, S.Q., Wasserstrum, N., Mombouli, J.V., and Vanhoutte, P.M. Role of extracellular calcium

and calcium channels in the response of human placental venous smooth muscle to endothelin-1. Am. J. Obstet Gynecol. 169: 1427-1430, 1993.

OR-419 Joly, G.A., Schini, V.B., Hughes, H. and Vanhoutte, P.M. Potentiation of the hyporeactivity

induced by in vivo endothelial injury in the rat carotid artery by chronic treatment with fish oil. Br. J. Pharmacol. 115: 255-260, 1995.

44

OR-420 Ge, T., Hughes, H., Junquero, D.C., Wu, K.K., Vanhoutte, P.M. and Boulanger, C.M. Endothelium-Dependent contractions are associated with both augmented expression of prostaglandin H synthase-1 and hypersensitivity to prostaglandin H2 in the SHR aorta. Circ. Res. 76: 1003-1010, 1995.

OR-421 Day, N.S., Ge, T., Codina, J., Birnbaumer, L., Vanhoutte, P.M. and Boulanger, C.M. Gi Proteins and the response to serotonin in cultured porcine endothelial cells with impaired release of EDRF. Br. J. Pharmacol. 115: 822-827, 1995.

OR-422 Desta, B., Vanhoutte,P.M., and Boulanger, C.M. Inhibition of the Angiotensin Converting

Enzyme by Perindoprilat and Release of Nitric Oxide. Am. J. Hypertens. 8: 1S-6S, 1995. OR-423 Nagao, T., Nakashima, M., Smart, F.W., Bond, R.A., Morrison, K.J., Vanhoutte, P.M.

Potentiation of endothelium-dependent hyperpolarization to serotonin by dietary intake of NC 020, a defined fish oil, in the porcine coronary artery. J. Cardiovasc. Pharmacol. 26: 679-681, 1995.

OR-424 Schini-Kerth, V.B., Fissithaler, B., Anderson, T.T., Fenton, J.W., Vanhoutte, P.M., Busse, R.

Thrombin prevents the expression of inducible nitric oxide synthase in vascular smooth muscle cells by a proteolytically-activated thrombin receptor. Thrombosis and Haemostasis 74: 980-6,1995.

OR-425 Mombouli, J.V., Nakashima, M., Hamra, M. and Vanhoutte, P.M. Endothelium-dependent

relaxation and and hyperpolarization evoked by bradykinin in canine coronary arteries : enhancement by exercise-training. Br. J. Pharmacol. 117: 413-418, 1996.

OR-426 Cordi, A.A., Lacoste, J.M., Descombes, J.J., Courchay, C., Vanhoutte, P.M., Laubie, M., and

Verbeuren, T.J. Design, Synthesis, and Structure-Activity Relationships of a New Series of -adrenergic Agonists: Spiro1,3-diazacyclopent-1-ene)5-2'-(1',2',3',4'-tetrahydronaphtha-lene). J. Med. Chem. 38: 4056-4069, 1995.

OR-427 Desta, B., Nakashima, M., Vanhoutte, P.M., and Boulanger, C.M. The Nitrate Ester ITF 296

Relaxes isolated Canine Arteries and Veins. J. Cardiovasc. Pharmacol. 26: S53-S58, 1995. OR-428 Illiano, S., Marsault, R., Descombes, J.J., Verbeuren, T. and Vanhoutte, P.M. Regulation of nitric

oxide-like activity by prostanoids in smooth muscle of the canine saphenous vein. Br. J. Pharmacol. 117: 360-364, 1996.

OR-429 Lee, J.J., Boulanger, C.M., Kirchengast, M., and Vanhoutte, P.M. Trandolapril Plus Verapamil

Inhibits the Coronary Vasospasm Induced by Hypoxia Following Ischemia-Reperfusion Injury in Dogs. Gener. Pharmac. 27: 1057-1059, 1996.

OR-430 Corriu, C., Félétou, M., Canet, E., and Vanhoutte, P.M. Inhibitors of the cytochrome P450-mono-

oxygenase and endothelium-dependent hyperplarizations in the guinea-pig isolated carotid artery. Br. J. Pharmacol. 117: 607-610, 1996.

OR-431 King, B.F., Dacquet, C., Ziganshin, A.U., Weetman, D.F., Burnstock, G., Vanhoutte, P.M., and

Spedding, M. 2,2'- pyridylisatogen tosylate potentiates ATP-responses at a recombinant P2Y1 purinoceptor. Br. J. Pharmacol. 117:1111-1118, 1996.

45

OR-432 Morrison, K.M. and Vanhoutte, P.M. Stimulation of sodium pump by Vasoactive Intestinal Peptide in guinea-pig isolated trachea: potential contribution to mechanisms underlying relaxation of smooth muscle. Br. J. Pharmacol. 118: 557-562, 1996.

OR-433 Pearson, P.J., Lin, P.J., Schaff, H.V., and Vanhoutte, P.M. Augmented endothelium-dependent

constriction to hypoxia early and late following reperfusion of the canine coronary artery. Clin. Exp. Pharmacol. Physiol. 23: 634-641, 1996.

OR-434 Marsault, R., Taddei, S., Boulanger, C.M., Illiano, S., and Vanhoutte, P.M. Rilmenidine activates

postjunctional alpha1 and alpha2 adrenoceptors in the canine saphenous vein. Fundam. Clin. Pharmacol. 10: 379-385, 1996.

OR-435 Mombouli, J.V., Bissiriou, I., Agboton, V.D., and Vanhoutte, P.M. Bioassay of Endothelium-

Derived Hyperpolarizing Factor. Biochem. Biophys. Res. Com. 221: 484-488, 1996. OR-436 Perrault, L.P., Menasché, P., Wassef, M., Bidouard, J.P., Janiak, P., Villeneuve, N., Jacquemin,

C., Bloch, G., Vilaine, J.P., and Vanhoutte, P.M. Endothelial effects of hemostatic devices for continuous cardioplegia or minimally invasive surgery. Ann. Thoracic Surg. 62: 1158-1163, 1996.

OR-437 Lee, J.J., Olmos, L., and Vanhoutte, P.M. Recovery of Endothelium-dependent relaxations four

weeks after ischemia and progressive reperfusion in canine coronary arteries. Proceedings of the Association of American Physicians 108: 362-367, 1996.

OR-438 Nakashima, M., Morrison, K.J., and Vanhoutte, P.M. Hyperpolarization and relaxation of canine

vascular smooth muscle to Vasoactive Intestinal Polypeptide. J. Cardiovasc. Pharmacol. 30: 273-277, 1997.

OR-439 Corriu, C., Félétou, M., Canet, E. and Vanhoutte, P.M. Endothelium derived factors and

hyperpolarization of the carotid artery of the guinea-pig. Br. J. Pharmacol. 119: 959-964, 1996. OR-440 Desta, B., Schultz, D., Ravel, D., Laudignon, N., Vanhoutte, P.M. and Boulanger, C.M. Acute

and chronic effects of dexfenfluramine on the porcine coronary artery. J. Pharmacol. Exp. Ther. 279: 1077-1085, 1996.

OR-441 Durante, W., Kroll, M.H., Orloff, G.J., Cunnigham, J.M., Scott-Burden, T., Vanhoutte, P.M., and

Schafer, A.I. Regulation of Interleukin-1-Stimulated Inducible Nitric Oxide Synthase Expression in Cultured Vascular Smooth Muscle Cells by Hemostatic Proetins. Biochem. Pharmacol. 51: 847-853, 1996.

OR-442 Mombouli, J.V., Bissiriou, I., Agboton, V.D., Alvear, J., Chelly, F., Kilbourn, R., and Vanhoutte,

P.M. Endotoxemia reduces the contribution of endothelium-derived hyperpolarizing factor; but augments that of prostanoids in canine coronary arteries. In: Endothelium-derived-hyperpolarizing factor, ed. Vanhoutte P.M., Harwood Academic publishers, pp.271-278, 1996.

OR-443 Marsault, R., Illiano, S. and Vanhoutte, P.M. Bradykinin-induced contractions of canine

saphenous veins: mediation by B2 receptors and involvement of eicosanoids. Br. J. Pharmacol. 120: 215-220, 1997.

46

OR-444 Perrault, L.P., Bidouard, J.P., Janiak, P., Villeneuve, N., Bruneval, P., Vilaine, J.P. and Vanhoutte, P.M. Time course of coronary endothelial dysfunction in acute untreated rejection after heterotopic heart transplantation. J. Heart and Lung Transplantation 16: 643-657, 1997.

OR-445 Perrault, L.P., Menasché, P., Bidouard, J.P., Jacquemin, C., Villeneuve, N., Vilaine, J.P. and

Vanhoutte, P.M. Snaring of the target vessel in less invasive bypass operations does not cause endothelial dysfunction. Ann. Thoracic Surgery 63: 751-755, 1997.

OR-446 Desta, B., Steed, Scott, Ravel, D., Laudignon, N., Vanhoutte, P.M. and Boulanger, C.M. Acute

and chronic effects of dexfenfluramine on the porcine pulmonary artery. Gener. Pharmacol. Gen. Pharmac. 30: 403-410, 1998.

OR-447 Borg-Capra, C., Fournet-Bourguignon, M.P., Janiak, P., Villeneuve, N., Bidouard, J.P., Vilaine,

J.P., Vanhoutte, P.M. Morphological heterogeneity with normal expression but altered function of G proteins in cultured regenerated porcine coronary endothelial cells. Br. J. Pharmacol. 122: 999-1008, 1997.

OR-448 Sansilvestri-Morel, P., Nonotte I., Fournet-Bourguignon, M.P., Rupin, A., Fabiani, J.N.,

Verbeuren, T., Vanhoutte, P.M. Abnormal deposition of extracellular matrix proteins by cultured smooth muscle cells from human varicose veins. J. Vascular Res. 35:115-123, 1998.

OR-449 De Ceuninck, F., Pastoureau, P., Bouet, F., Bonnet, J. Vanhoutte, P.M. Purification of guinea pig

YKL40 and modulation of its secretion by cultured articular chondrocytes. J. Cellular Biochem. 69:414-424, 1998.

OR-450 Weigert, A.L., Vanhoutte, P.M. Prolonged administration of high dose cylosporine A enhances

the endothelium-dependent component of the relaxation to isoproterenol in the rat aorta. Rev. Port. Nefrol. Hipert. 11: 345-351, 1997.

OR-451 Flavahan, N.A., Hales, M.A., Aleskowitch, T.D., Gaine, S.P., Vanhoutte, P.M. 1-Adrenoceptors

in canine pulmonary artery. J. Cardiol. Pharmacol., 32 :308-316, 1998. OR-452 Chataigneau, T., Félétou, M., Duhault, J., Vanhoutte, P.M. Epoxyeicosatrienoic acids, potassium

channel blockers and endothelium-dependent hyperpolarization in the guinea-pig carotid artery. Br. J. Pharmacol. 123: 574-580, 1998.

OR-453 Chataigneau, T., Félétou, M., Thollon, C., Villeneuve, N., Vilaine, J.P., Duhault, J., and

Vanhoutte, P.M. Cannabinoid CB1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries. Br. J. Pharmacol. 123: 968-974, 1998.

OR-454 Thollon C., Fournet-Bourguignon M.P., Bidouard J.P., Cambarrat C., Saboureau D., Delescluse

I., Vanhoutte P.M., and Vilaine J.P. Contribution of nitric oxide and endothelium-derived hyperpolarizing factor to the relaxation evoked by bradykinin in porcine coronary arteries four weeks after removal of the endothelium. In: Endothelium-derived-hyperpolarizing factor, ed. Vanhoutte P.M., ed. Harwood Academic publishers, 1996.

OR-455 Chataigneau T., Thollon C., Villeneuve N., Vilaine J.P., Duhault J., Félétou M., Vanhoutte P.M.

EDHF does not activate cannabinoid CB1 receptor in rat mesenteric, guinea-pig carotid and

47

porcine coronary arteries. In: Endothelium-dependent hyperpolarizations, ed. P.M. Vanhoutte, Harwood Academic publishers, pp 167-173, 1999.

OR-456 Quignard J.F., Chataigneau T., Corriu C., Duhault J., Félétou M., and P.M. Vanhoutte. Effects of

SIN-1 on potassium channels of vascular smooth muscle cells of the rabbit aorta and guinea-pig carotid artery. In : Endothelium-dependent hyperpolarizations, ed. P.M. Vanhoutte, Harwood Academic publishers, pp 193-199, 1999.

OR-457 Quignard J.F., Chataigneau T., Corriu C., Duhault J., Félétou M., and P.M. Vanhoutte. Potassium

channels involved in EDHF-induced hyperpolarization of the smooth muscle cells of the isolated guinea-pig carotid artery. In : Endothelium-dependent hyperpolarizations, ed. Vanhoutte P.M., Harwood Academic publishers, pp 201-208, 1999.

OR-458 Chataigneau T.,Félétou M., Huang P.L., Fishman M.C., Duhault J.,and Vanhoutte P.M.

Endothelium-dependent responses in endothelial nitric oxide synthase knockout mice: contribution of NO, EDHF and products of cyclooxygenase. In Endothelium-dependent hyperpolarizations, ed. Vanhoutte P.M., Harwood Academic publishers, pp 125-132, 1999.

OR-459 Corriu C., Félétou M., Puybasset L., Bea M.L., Berdeaux A., Vanhoutte P.M. Endothelium-

dependent hyperpolarization in isolated arteries taken from animals treated with NO-Synthase inhibitors. J. Cardiovasc. Pharmacol., 32: 944-950, 1998.

OR-460 Boulanger C., Heymes C., Benessiano, J., Geske R., Lévy B., Vanhoutte P.M. Neuronal nitric

oxide synthase is expressed in rat vascular smooth muscle cells: activation by angiotensin II in hypertension. Circ. Res., 83: 1271-1278, 1998.

OR-461 Chataigneau T., Félétou M., Huang P.L., Fishman M.C., Duhault J., and Vanhoutte P.M.

Acetylcholine-induced relaxation in blood vessels from endothelial nitric oxide synthase knockout mice. Br. J. Pharmacol.,126: 219-226, 1999.

OR-462 Quignard, J.F., Félétou, M., Thollon, C., Vilaine, J.P., Duhault, J.and Vanhoutte, P.M. Potassium

ions and endothelium-derived hyperpolarizing factor in guinea-pig carotid and porcine coronary arteries. Br. J. Pharmacol., 127: 27-34, 1999.

OR-463 Thollon, C., Bidouard, J.P., Cambarrat, C., Delescluse, I., Villeneuve, N., Vanhoutte, P.M. and

Vilaine, J.P. Alteration of endothelium-dependent hyperpolarizations in porcine coronary arteries with regenerated endothelium. Circ. Res. 84: 371-377, 1999.

OR-464 Perrault, L.P. , Bidouard, J.P., Janiak, P., Villeneuve, N., Bruneval, P., Vilaine J.P., and

Vanhoutte, P.M. Impairment of G-protein-mediated signal transduction in the porcine coronary endothelium during rejection after heart transplantation. Cardiovasc Research, 43: 457-470, 1999.

OR-465 Kim, N.D., Kang, K.W., Kang, S.Y. Vanhoutte, P.M. Alpha-2 adrenoceptor antagonists evoke

endothelium-dependent and – independent relaxations in the isolated rat aorta. J. Cardiovasc. Pharmacol. 34: 148-152, 1999.

OR-467 Edwards, G., Gardener M.J., Félétou M., Brady G.F.,Vanhoutte P.M., and Weston A.H. Further

investigation of endothelium-derived hyperpolarizing factor (EDHF) in rat hepatic artery: studies using 1-EBIO and ouabain. Br. J. Pharmacol., 128: 1064-1070, 1999.

48

OR-468 Park, S-J, Nakashima M., Nagao, T., Vanhoutte, P.M. Hyperpolarization caused by serotonin contributes to endothelium-dependent relaxations in the porcine coronary artery. Acta Pharmacologica Sinica, 20: 1093-1097, 2000.

OR-469 De Vriese, A.S., Verbeuren, T.J., Vallez, M.O., Lameire, N.H., De Buyzere, M., and Vanhoutte,

P.M. Off-Line analysis of red blood cell velocity in renal arterioles. J. Vasc. Research, 37: 26-31, 2000.

OR-470 Park, S-J, Lee, J.L., and Vanhoutte, P.M. Endothelin-1 releases endothelium-derived

endoperoxides and thromboxane A2 in porcine coronay arteries with regenerated endothelium. Acta Pharmacol. Sinica, 20: 872-878, 1999.

OR-471 Ge, T., Vanhoutte, P.M., and Boulanger, C.M. Increased response to Prostaglandin H2 precedes

changes in PGF-synthase 1 expression in the SHR aorta. Acta Pharmacologica Sinica, 20: 1087-1092, 1999.

OR-472 Perrault, L., Mahlberg, F., Breugnot, C., Bidouard, J-P., Villeneuve, N., Vilaine J-P, and

Vanhoutte, P.M. Hypercholesterolemia Increases coronary endothelial dysfunction, lipid content and accelerated atherosclerosis after heart transplantation. Arterioscler. Thromb. Vasc. Biol., 20: 728-736, 2000.

OR-473 Quignard, J-F, Félétou, M., Edwards, G., Duhault, J., Weston, A.H., Vanhoutte, P.M. Role of

endothelium cells hyperpolarization in EDHF-mediated responses in the guinea-pig carotid artery. Br. J. Pharmacol, 129: 1103-1112, 2000.

OR-474 Fournet-Bourguignon, M.P., Castedo-Delrieu, M., Bidouard, J.P., Leonce, S., Saboureau, D.,

Delescluse, I., Vilaine, J.P., Vanhoutte, P.M. Phenotopic and functional changes in regenerated porcine coronary endothelial cells. Increased uptake of modified LDL and reduced production of NO. Circ. Res., 86: 854-861, 2000.

OR-475 Edwards, G., Félétou, M., Gardener, M.J., Thollon, C., Vanhoutte, P.M., and Weston, A.H. Role

of gap junctions in the responses to EDHF in rat and guinea-pig small arteries. Br. J. Pharmacol., 128: 1788-1794, 1999.

OR-476 Edwards, G., Thollon, C., Gardener, M.J., Félétou, M., Vilaine, J.P., Vanhoutte, P.M., and

Weston, A.H. Role of gap junctions and EETs in endothelium-dependent hyperpolarization of porcine coronary artery. Br. J. Pharmacol. 129: 1145-1154, 2000.

OR-477 Quignard, J.F., Félétou, M., Corriu, C., Chataigneau, T. , Edwards, G., Weston, A.H., Vanhoutte,

P.M. 3-Morpholinosydnonimine (SIN-1) and K+ channels in smooth muscle cells of the rabbit and guinea-pig carotid arteries. Eur. J. Pharmacol., 399: 9-16, 2000.

OR-478 Deprez-Roy I., Coge, F., Bertry, L., Galizzi, J.P., Félétou, Vanhoutte P.M., Canet, E Endothelin-1

pathway in human alveolar epithelial cell line A549 and human umbilical vein endothelial cells. Acta Pharmacol Sinica, 21: 499-506, 2000.

OR-479 Brandes, R.P., Schmitz-Winnenthal, F., Félétou, M., Gödecke, A., Huang, P.L., Vanhoutte, P.M.,

Fleming, I., Busse, R. An Endothelum-derived hyperpolarizing factor distinct from NO and PGI2 is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knock-out mice. PNAS, 97: 9747-9752, 2000.

49

OR-480 Miller, V.M., Vanhoutte, P.M. Prostaglandins but not Nitric Oxide are endothelium-derived

relaxing factors in the trout aorta. Acta Pharmacologica Sinica, 21: 871-876, 2000. OR-481 Yang, Q., Scalbert, E., Delagrange, P., Vanhoutte, P.M., O'Rourke, S.T. Melatonin Potentiates

contractile Responses to serotonin in isolated Porcine Coronary Arteries, Am . J. Physiol., 280: H76-H82, 2001.

OR-482 Félétou, M., Lonchampt, M., Coge, F., Galizzi, J.P., Bassoullet, C., Merial,C., Robineau, P.,

Boutin, J.A., Huang, P.L., Vanhoutte, P.M., Canet, E. Regulation of Murine Airway Responsiveness by Endothelial Nitric Oxide Synthase. Am. J. Physiol., 281 : L258-L267, 2001.

OR-483 De Ceuninck, F., Pastoureau, P., Agnellet, S., Bonnet, J., Vanhoutte, P.M. Development of an

enzyme-linked immunoassay for the quantification of YKL-40 (cartilage gp-39) in guinea pig serum using hen egg yolk antibodies. J. Immunol. Methods, 252 :153-161, 2001.

OR-484 Bruban, V., Feldman, J., Greney, H., Dontenwill, M., Schann, S., Jarry, C., Payard, M., Boutin, J.,

Scalbert, E., Pfeiffer, B., Renard, P., Vanhoutte, P.M., Bousquet, P. Respective contributions of -adrenergic and non-adrenergic mechanisms in the hypotensive effect of imidazoline-like drugs. Br. J. Pharmacol., 133: 261-266, 2001.

OR-485 Corriu, C., Félétou, M., Edwards, G., Weston, A. and Vanhoutte, P.M. Differential effects of

prostacyclin and iloprost in the isolated carotid artery of the guinea-pig. Eur. J. Pharmacol., 426: 89-94, 2001.

OR-486 Sansilvestri-Morel, P., Rupin, A., Badier-Commander, C., Kern, P., Fabiani, J-N, Verbeuren, T.J.

and Vanhoutte, P.M. Imbalance in the synthesis of collagen type I and collagen type III in smooth muscle cells derived from human varicose veins. J. Vascular Res., 38: 560-568, 2001.

OR-487 Edwards, G, Félétou, M., Gardener, M.J., Glen, C.D., Richards, G.R., Vanhoutte, P.M. and

Weston, A.H. Further investigations into the endothelium-dependent hyperpolarizing effects of bradykinin ad substance P in porcine coronary artery. Br. J. Pharmacol., 133: 1145-1153, 2001.

OR-488 Richards, G.R., Weston, A.H., Burnham, M.P., Félétou, M., Vanhoutte, P.M. and Edwards, G.

Supression of K+-induced hyperpolarization by phenylephrine in rat mesenteric artery : relevant to studies of entodothelium-derived hyperpolarizing factor. Br. J. Pharmacol., 134: 1-5, 2001.

OR-489 Mombouli, J.V., Ballard, K.D., Vanhoutte, P.M. Kininase-independent potentiation of

endothelium-dependent relaxations to kinins by converting enzyme inhibitor perindoprilat. Acta Pharmacol. Sinica, 23: 203-207, 2002.

OR-490 Yang, D., Félétou, M., Boulanger, C.M., Wu, Heng-Fang, Levens, N., Zhang, Ji-Nan, Vanhoutte,

P.M. Oxygen-Derived Free Radicals Mediate Endothelium-Dependent Contractions to Acetylcholine in Aortas from Spontaneously Hypertenive Rats. Br. J. Pharmacol., 136: 104-110, 2002.

OR-491 Quignard, J.F., Chataigneau, T., Corriu, C., Edwards, G., Weston, A. Félétou, M., Vanhoutte,

P.M. Endothelium-dependent hyperpolarization to acetylcholine in the carotid artery of the guinea-pig: role of lipoxygenase. J. Cardiovasc. Pharmacol., 40: 467-477, 2002.

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OR-492 Burnham, M.P., Bychkov, R., Félétou, M., Richards, G.R., Vanhoutte, P.M., Weston, A.H., Edwards, G. Characterization of an apamin-sensitive small-conductance Ca2+-activate K+ channel in porcine coronary artery endothelium: relevance to EDHF. Br. J. Pharmacol., 135: 1133-1143, 2002.

OR-493 Sansilvestri-Morel, P., Rupin, A., Jaisson, S., Fabiani, J.N., Verbeuren, T.J., Vanhoutte, P.M. The

synthesis of collagen is dysregulated in cultured fibroblasts derived from skin of subjects with varicose veins as it is in venous smooth muscle cells. Circulation, 106: 479-483, 2002.

OR-494 Vanhoutte, P.M., Fournet-Bourguignon M.P., Vilaine, J.P. Dysfonction de la voie du monoxide

d’azote au cours de la régénération de l’endothélium coronarien. Académie Nationale de Médecine, 186: 1525-1541, 2002.

OR-495 Thollon, C., Fournet-Bourguignon, M.P., Saboureau, D., Lesage, L., Reure, H., Vanhoutte, P.M.

and Vilaine, J.P. Consequences of reduced production of NO on vascular reactivity of porcine coronary arteries after angioplasty : importance of EDHF. Br. J. Pharmacol., 136: 1153-1161, 2002.

OR-496 Perrault, L.P., Malo, O., Desjardins, N., Bidouard, J.P., Villeneuve, N., Vilaine, J.P., and

Vanhoutte, P.M. Surgical Experience with retroperitoneal heterotopic heart transplantation in the large white domestic swine. J. Investigative Surgery, 15:45-55, 2002.

OR-497 Weston, A.H., Richards, G.R., Burnham, M.P., Félétou, M., Vanhoutte, P.M. and Edwards, G.

K+-Induced hyperpolarization in rat mesenteric artery: identification, localisation and role of Na+/K+-ATPases. Br. J. Pharmacol., 136: 918-926, 2002.

OR-498 Perrault, L.P., Bidouard, J.P., Desjardins N., Villeneuve N., Vilaine, J.P., and Vanhoutte, P.M.

Comparison of coronary endothelial dysfunction in the working and nonworking graft in porcine heterotopic heart transplantation. Transplantation, 74: 764-772, 2002.

OR-500 Olmos, L., Mombouli, J.V., Wasserstrum, N., and Vanhoutte, P.M. The ability of sickle cells to

scavenge endothelium-derived nitric oxide is reduced. Acta Pharmacologica Sinica, 23: 967-973, 2002.

OR-501 Bychlov, R., Burham, M.P., Richards, G.R., Edwards G., Weston A.H., Félétou, M., and

Vanhoutte, P.M. Characterization of a charybdo-sensitive intermediate conductance Ca2+-activated K+ channel in porcine coronary endothelium: relevance to EDHF. Br. J. Pharmacol., 137: 1346-1354, 2002.

OR-502 Yang, D., Levens, N., Zhang, J.N., Vanhoutte, P.M., and Félétou, M. Specific potentiation of

endothelium-dependent contractions in SHR by tetrahydrobiopterin. Hypertension, 41: 136-142, 2003.

OR-503 Yang, D., Félétou, M., Levens, N., Zhang, J.N., and Vanhoutte, P.M. A diffusible substance(s)

mediates endothelium-dependent contractions in the aorta of SHR. Hypertension, 41: 143-148, 2003.

OR-504 Quignard, J.F., Harley,E.A., Duhault J.,Vanhoutte, P.M. and Félétou, M., K+ channels in

cultured bovine retinal pericytes : effects of beta-adrenergic stimulation. J. Cardiovasc. Pharmacol., 42:379-388, 2003.

51

OR-505 Gardener, M.J., Edwards, G., Félétou, M., Vanhoutte, P.M., and Weston, A.H. Effects of Hepes

on EDHF responses in porcine coronary and rat mesenteric arteries. In: “EDHF 2002”, ed. P.M. Vanhoutte, pp. 239-247, 2003.

OR-506 Edwards, G., Richards, G., Gardener, M.J., Félétou, M., Vanhoutte, P.M., and Weston, A.H.

Roles of the inward-rectifier K+ channel and Na+/K+-ATPase in the rat mesenteric artery hyperpolarization to K+. In: “EDHF 2002”, ed. P.M. Vanhoutte, pp.309-317, 2003.

OR-507 O’Rourke, S.T., Hammad, H., Delagrange, P., Scalbert, E., and Vanhoutte, P.M. Melatonin

Inhibits Nitrate Tolerance in isolated coronary arteries. Br. J. Pharmacol., 139: 1326-32, 2003. OR-508 Shibano, T., and Vanhoutte P.M. Low molecular weight G-proteins of the Rho-family mediate

the relaxations to bradykinin in porcine coronary arteries. Acta Pharmacologica Sinica, 24: 1070-1076, 2003.

OR-509 De Ceuninck, F., Allain, F., Caliez, A., Spik, G. and Vanhoutte, P.M. High binding Capacity of

cyclophilin B to chondrocyte Heparan Sulfate Proteoglycans an dits release from the cell surface by matrix metalloproteinases. Arthritis and Rheumatism, 48: 2197-2206, 2003.

OR-510 Kennedy, S., Fournet-Bourguignon, M-P., Breugnot, C., Castedo-Delrieu, M., Lesage, L.,

Reure, H., Briant, C., Leonce, S., Vilaine, J-P. and Vanhoutte, P.M. Cells derived from regenerated endothelium of the porcine coronary artery contain more oxidized forms of Apolipoprotein-B-100 without a modification in the uptake of oxidized LDL. J. Vasc. Res. 40: 389-398, 2003.

OR-511 Yang, D., Gluais, P., Zhang, J.N., Vanhoutte, P.M. and Félétou, M. Endothelium-dependent

Contractions to Acetylcholine, ATP and the Calcium Ionophore A23187 in aortas from Spontaneously Hypertensive and Normotensive Rats. Fund. Clin. Pharmacol., Funda & Clinical Pharmacology 18: 321-326, 2004.

OR-512 Zellers, T,M., Wu, Y-Q.,McCormick, J. and Vanhoutte, P.M. Prostacyclin-induced relaxations

of small porcine pulmonary arteries are enhanced by the basal release of endothelium-derived nitric oxide through an effect on cyclic GMP-inhibited-cyclic AMP phosphodiesterase. Acta Pharmacol. Sinica, 21: 131-138, 2001.

OR-513 Yang, D., Gluais, P., Zhang, J.N., Vanhoutte, P.M. and Feletou, M. Nitric Oxide and Inactivation

of the Endothelium-dependent Contracting Factors released by Acetylcholine in SHR. J.Cardiovasc. Pharm., 43: 815-820, 2004.

OR-514 Villeneuve, N., Fortuno, A., Jacquemin, C., Sauvage, M., Vanhoutte, P.M., Vilaine, J.P..

Peristence of the nitric oxide pathway in the aorta of hypercholesterolemic apolipoprotein E-deficient mice. J Vasc Res, 40: 87-96, 2003.

OR-515 Gluais, P., Edwards, G., Weston, A.H., Falck, J.R., Vanhoutte, P.M. and Félétou, M. Role of

SKCa and IKCa in endothelium-dependent hyperpolarizations of the guinea-pigisolated carotid artery. B.J. Pharmacol., 144: 477-485, 2005.

52

OR-516 Bos, R., Mougenot, N., Findji, L., Médiani, O, Vanhoutte, P.M., Lechat, P. Potassium Canrenoate, an Aldosterone Receptor Antagonist, Reduces Isoprenaline-Induced Cardiac Fibrosis in the Rat. J Pharmacology and Exp Ther., 309:1160-1166, 2004.

OR-517 Lee, M.Y.K., Leung, S.W.S., Vanhoutte, P.M., Man, R.Y.K. Genistein reduces agonist-induced

contractions of porcine coronary arterial smooth muscle in a cyclic AMP-dependent manner. European Journal of Pharmacology, 503: 165-172, 2004.

OR-518 Chan, Y.C., Leung, F. P., Yao, X.Q., Lau, C. W., Vanhoutte, P.M., and Huang, Y. Raloxifene

Relaxes Rat Pulmonary Arteries and Veins: Roles of Gender, Endothelium and Antagonism of Ca2+ Influx. J Pharm Experimental Therapeutics, 312: 1266-1271, 2005.

OR-519 Gluais, P., Edwards, G., Weston, A.H., Vanhoutte, P.M., and Feletou, M. Hydrogen Peroxide and

Endothelium-Dependent Hyperpolarization in the Guinea-Pig Carotid Artery. European Journal of Pharmacology 513: 219-224, 2005

OR-520 Keung, W., Vanhoutte, P.M. and Man, R.Y.K. Acute impairment of contractile responses by

17β-estradiol is cAMP and protein kinase G dependent in vascular smooth muscle cells of the porcine coronary arteries. Br. J. Pharmacol., 144: 71-79, 2005

OR-521 Miao, C.Y., Vileneuve, N., Christine, B.J., Petit, C., Guillaumin, J.P., Gransagne, D., Briant, C.,

Vilaine, J.P., Vanhoutte, P.M. Chronic Mild Hyperhomocysteinemia Induces Aortic Endothelial Dysfunction but Does Not Elevate Arterial Pressure in Rats. J Vasc Res, 42: 148-156, 2005.

OR-522 Brouri, F., Hanoun, N., Mediani, O., Saurini, F., Hamon, M., Vanhoutte, P.M. and Lechat, P.

Blockade of β1- and desensitization of β2-adrenoceptors reduce isoprenaline-inducted cardiac fibrosis. European Journal of Pharmacology, 485: 227-234, 2004.

OR-523 Weston, A.H., Félétou, M., Vanhoutte, P.M., Falck, J.R., Campbell W.B., Edwards, G.

Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids. Br. J. Pharmacol., 145: 775-784, 2005.

OR-524 Tang, E.H.C., Feletou, M., Huang, Y., Man, R.Y.K. and Vanhoutte, P.M. Acetylcholine and

Sodium Nitroprusside Cause Long-Term Inhibition of EDCF-Mediated Contraction. Am. J. Physiol Heart and Circ Physiol., 289: H2434-H2440, 2005.

OR-525 Gluais, P., Lonchampt, M., Morrow, J.D., Vanhoutte, P.M. and Feletou, M. Acetylcholine-

induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin. Br. J. Pharmacol, 146, 834-845, 2005.

OR-526 Tang, E.H.C., Ku D.D., Tipoe, G.L., Feletou, M., Man, R.Y.K., Vanhoutte, P.M. Endothelium-

Dependent Contractions Occur in the Aorta of Wild Type and COX2-/- Knockout but not COX1-/- Knockout Mice. J Cardiovasc. Pharm, 46: 761-5, 2005.

OR-527 Keung, W., Vanhoutte, P.M., and Man, R.Y.K. Non-genomic responses to 17β-estradiol in male

rat mesenteric arteries abolish intrinsic gender differences in vascular responses. Br. J. Pharmacol., 146: 1148-1155, 2005.

53

OR-528 Rasmussen, L.E., Vanhoutte, PM., Jensen, B.L., and Skott, Ole. Continuous flow augments the reactivity of the rabbit carotid artery by reducing the bioavailability of NO despite an increase in the release of EDHF. Am. J. Physiol. Heart and Circulatory Physiol, 291: 1521-1528, 2006.

OR-529 Wong, C.M., Yao, X., Au, C.L., Tsang, S.Y., Fung, K.P., Laher, I., Vanhoutte, P.M., Huang, Y.

Raloxifene prevents endothelial dysfunction inaging ovariectomized female rats. Vascular Pharmacology 44: 290-298, 2006.

OR-530 Leung, H.S., Leung, F.P., Yao, X., Ko, W.H., Chen, Z.Y., Vanhoutte, P.M., Huang, Y.

Endothelial mediators of the acetylcholine-induced relaxation of the rat femoral artery. Vascular Pharmacology 44: 299-308, 2006.

OR-531 Shi, Y., Ku, D.D., Man, R.Y.K., and Vanhoutte, P.M. Augmented endothelium-derived

hyperpolarizing factor-mediated relaxations attenuate endothelial dysfunction in femoral and mesenteric, but not in carotid arteries from type I diabetic rats. JPET, 318: 276-281, 2006.

OR-532 Gluais, P., Paysant, P., Badier-Commander, C., Verbeuren, T., Vanhoutte, P.M., and Feletou, M.

In SHR aorta, calcium ionophore A 23187 releases prostacyclin and thromboxane A2 as endothelium-derived contracting factors (EDCF). Am J Physiol: Heart Circ Physiol, 291: 2255-2264, 2006.

OR-533 Yeung, D.K.Y., Leung S.W.S., Xu, Y.C., Vanhoutte, P.M., Man, R.Y.K. Puerarin, an

isoflavonoid derived from Radix puerariae, potentiates endothelium-dependent relaxation via the cyclic AMP pathway in porcine coronary arter. Eur. J. Pharmacol., 552: 105-111, 2006.

OR-534 Gluais, P., Vanhoutte, P.M. and Feletou, M. Mechanisms underlying ATP-induced endothelium-

dependent contractions in the SHR aorta. Eur. J. Pharmacology, 556: 107-114, 2007. OR-535 Shi, Y., Feletou, M., Ku, D.D., Man, R.Y.K., Vanhoutte, P.M. The calcium ionophore A23187

induces endothelium-dependent contractions in fermoral arteries from rats with streptozotocin-induced diabetes. Br. J. Pharmacol., 150: 624-432, 2007.

OR-536 Tang, E.H.C., Leung, F.P., Huang, Y., Félétou, M., So, K.F., Man, R.Y.K., Vanhoutte, P.M.

Calcium and reactive oxygen species increase in endothelial cells in response to releasers of endothelium-derived contracting factor. British Journal of Pharmacology, 151: 15-23, 2007.

OR-537 E1-Hamamsy, I., Stevens, L.M., Vanhoutte, P.M., Perrault, L.P. Denudation of the coronary

endothelium at implantation increases endothelial dysfunction and intimal hyperplasia after heart transplantation. J. Heart Lung Transplant., 24:251-258, 2005.

OR-538 Perrault, L.P., Malo, O., Thollon, C., Villeneuve, N., Vilaine, J.P., Vanhoutte, P.M. Status of the

endothelium-derived hyperpolarizing factor pathway in conronary arteries after heterotopic heart transplantation. J. Heart Lung Transplant. 26: 48-55, 2007.

OR-539 Chan, Y.C., Leung, F.P., Yao, X., Lau, C.W., Vanhoutte, P.M., Huang Y. Raloxifene modulates

pulmonary vascular reactivity in spontaneously hypertensive rats. J. Cardiovascular Pharmacology, 49: 355-361, 2007.

54

OR-540 Li, R.W.S., Tse, C.M., Man, R.Y.K., Vanhoutte, P.M., Leung, G.P.H. Inhibtion of human equilibrative nucleoside transporters by dihydropyridine-type calcium channel antagonists. Eur. J. Pharmacol., 568: 75-82, 2007.

OR-541 Uhrenholt, T.R., Schjerning, J., Vanhoutte, P.M., Jensen, B.L. and Skott, O. Intercellular calcium

signaling and nitric oxide feedback during constriction of rabbit renal afferent arterioles.Am. J. Physiol. Renal Physiol. 292: 1124-1131, 2007.

OR-542 Leung, F.P., Yung, L.M., Leung, H.S., Au, C.L., Yao, X., Vanhoutte, P.M., Laher, I., Huang Y.

Therapeutic concentrations of raloxifene augment nitric oxide-dependent coronary artery dilatation in vitro. Br.J. Pharmacol., 152: 223-229, 2007.

OR-543 Michel, F.S., Man, R.Y.K., Vanhoutte, P.M. Increased spontaneous tone in renal arteries of

spontaneously hypertensive rats (SHR). Am. J. Physiol. Heart Circul. Physiol., 293: 1673-1681. 2007.

OR-544 Shi, Y., So, K.F., Man, R.Y.K., Vanhoutte, P.M. Oxygen-derived free radicals mediate

endothelium-dependent contractions in femoral arteries of rats with streptozotocin-induced diabetes. Br. J. Pharmacol., 152: 1033-1041, 2007.

OR-545 Lee, M.Y.K., Tse, H.F., Siu, C.W., Zhu S.G., Man R.Y.K., Vanhoutte, P.M. Genomic changes in

regenerated porcine coronary arterial endothelial cells. ATVB, 27: 2443-2449, 2007. OR-546 Leuranguer, V., Vanhoutte, P.M., Verbeuren, T., Félétou, M. C-type natriuretic peptide and

endothelium-dependent hyperpolarization in the guinea-pig carotid artery. Br. J. Pharmacol., 153: 57-65, 2008.

OR-547 Shi, Y., Man, R.Y.K., Vanhoutte, P.M. The two isoforms of cyclooxygenase contribute to the

augmented endothelium-dependent contractions in femoral arteries of one year old rats. Acta Pharmacologica Sinica, 29: 185-192, 2008.

OR-548 Hristovska, A., Rasmussen, L.E., Hansen, P.B.L., Nielsen, S.S., Nüsing, R.M., Narumiya, S.,

Vanhoutte, P., Skøt, O., Jensen, B.L. Prostaglandin E2 induces vascular relaxation by E-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthease. Hypertension, 50: 525-530, 2007.

OR-549 Tang, E.H.C., Jensen, B., Skott, O., Leung, G.P.H., Feletou, M., Man, R.Y.K., Vanhoutte, P.M.

The role of EP and TP receptors in the response to prostaglandin E2 in the aorta of WKY and SHR. Cardiovascular Research, 78: 130-138, 2008.

OR-550 Ng, W.W.H., Keung, W., Xu, Y.C., Ng, K.F.J., Leung, G.P.H., Vanhoutte, P.M., Choy, P.C. ,

Man, R.Y.K. Genistein potentiates protein kinase A activity in porcine coronary artery. Mol. Cell. Biochem., 311: 37-44, 2008.

OR-551 Li, G.T., Wang, H.B., Qin, G.W., Jin, M.W., Qiang, T, Sun, H.Y., Du, X.L., Deng, X.L., Zhang,

X.H., Chen, J.B., Chen, L., Xu, S.H., Cheng, L.C., Chiu, S.W., Tse, H.F., Vanhoutte, P.M., Lau, C.P. Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs. Circulation, 117: 2449-2457, 2008.

55

OR-552 Xu, Y.C., Leung, G.P.H., Wong, P.Y.D., Vanhoutte, P.M., Man, R.Y.K. Kaempferol stimulates large conductance Ca2+-activated K+ (BKCa) channels in human umbilical vein endothelial cells (HUVECs) via cAMP/PKA-dependent pathway. Br. J. Pharmacol., 154:1247-1253. 2008.

OR-553 Wong, M.S.K., Delansorne, R., Man, R.Y.K., Vanhoutte, P.M. Vitamin D derivatives acutely

reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol.: Heart Circ Physiol., 295:H289-H296, 2008.

OR-554 Michel, F.S., Man, G.S., Man, R.Y.K., Vanhoutte, P.M. Hypertension and the absence of EDHF-

mediated responses favor endothelium-dependent contractions in renal arteries of the rat. Br. J. Pharmacol. 13: 4198-4217, 2008.

OR-555 Shi, Y, Vanhoutte, P.M. Oxidative stress and COX cause hyper-responsiveness in vascular

smooth muscle of the femoral artery from diabetic rats. Br. J. Pharmacol., 154: 639-651, 2008. OR-556 Li, R.W.S., Man, R.Y.K., Vanhoutte, P.M., Leung, G.P.H. Stimulation of ecto-5’ nucleotidase in

human umbilical vein endothelial cells by lipopolysaccharide. Am. J. Physiol. Heart and Circulatory Physiology, 295:H1177-H1181, 2008.

OR-557 Tang, E.H.C., Vanhoutte, P.M. Gap junction inhibitors reduce endothelium-dependent

contractions in the aorta of sponteanously hypertensive rats. JPET, 327(1): 1-6, 2008. OR-558 Leuranguer, V., Gluais, P., Vanhoutte, P.M. Openers of calcium-activated potassium channels

and endothelium-dependent hyperpolarizations in the guinea pig carotid artery. Naunyn-Schmiedeberg’s Arch Pharmacol, 377: 101-109, 2008.

OR-559 Tang, E.H.C., Vanhotute, P.M. Gene expression changes of prostanoid synthases in endothelial

cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. Physiol Genomics, 32: 409-418, 2008.

OR-560 Lee, M.Y.K., Sorensen G.L., Holmskov, U., Vanhoutte, P.M. The presence and activity of SP-D

in porcine coronary endothelial cells depend on Akt/PI3K, Erk and nitric oxide and decrease after multiple passaging. Molecular Immunology, 46: 1050-1057, 2009.

OR-561 Al-Mashhadi, R.H., Skott, O., Vanhoutte, PM., Hansen P.B. Adenosine dilates the cortical

efferent arteriole of the mouse by activating A2 adenosine receptors. Kidney International, 75:793-799, 2009.

OR-562 Wong, S.L., Leung, F.P., Lau, C.W., Au, C.L., Yung, L.M., Yao, X., Chen, Z.Y., Vanhoutte,

P.M., Gollasch, M., Huang, Y. Cyclooxygenase-2-derivd PGF2α mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during ageing. Circulation Research, 104:228-235, 2009.

OR-563 Walter A, Etienne-Selloum N, Brasse D, Schleiffer R, Bekaert V, Vanhoutte PM, Beretz A,

Schini-Kerth VB. Red wine polyphenols prevent acceleration of neovascularisation by Ang II in the ischemic rat hindlimb. J Pharmacol Exp Ther 329:699-707, 2009.

OR-564 Xu, A., Wang, H., Hoo, R.L.C., Sweeney, G., Vanhoutte, P.M., Wang, Y., Wu, D., Chu, W., Qin,

G., Lam, K.S.L. Selective elevation of adiponectin production by the natural compounds derived

56

from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice. Endocrinology 150: 625-633, 2009.

OR-565 Chan, C.K.Y., Mak, J.C., Man, R.Y.K., Vanhoutte, P.M. Rho kinase inhbitors prevent

endothelium-dependent contractions in the rat aorta. J Pharmacol Exp Ther 329: 820-826, 2009. OR-566 Wang, Y., Huang Y., Lam, K.S.L., Li Y., Wong, W.T., Ye, H., Lau, C.W., Vanhoutte, P.M., Xu,

A. Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via AMP-activated kinase and eNOS. Cardiovascular Research, 82: 484-492, 2009.

OR-567 Cheng, K.K.Y., Iglesias, M.A., Lam, K.S.L. Lam, Wang, Y., Sweeney, G, Zhu, W., Vanhoutte,

P.M., Kraegen, E.W., Xu, A. APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice. Cell Metabolism, 9: 417-427, 2009

OR-568 Law, I, Liu, L., Xu, A., Lam, K., Vanhoutte, P., Che, C.M., Leung, P. Wang, Y. Identification

and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of Sirtuins. Proteomics, 9: 2444-2456, 2009.

OR-569 Lee, M.Y.K., Wang, Y., Vanhoutte, P. Senescence of cultured porcine coronary arterial

endothelial cells is associated with accelerated oxidative stress and activation of NFκB. J Vascular Research, 47: 287-298, 2010.

OR-570 Xia, Z., Lui, T., Luo, T., Liu, H.M., Wang, F., Xia, Z.Y., Irwin, M.G., Vanhoutte, P.M. L-

Arginine enhances nitrative stress and exacerbates TNF-Alpha toxicity to human endothelial cells in culture: prevention by propofol. J Cardiovasc Pharmacol, 55(4): 358-367, 2010.

OR-571 Law, I., Xu, A.,, Lam, K., Berger, T., Mak, T., Vanhoutte, P., Liu, J., Sweeney, G., Zhou, M.,

Yang, B., Wang, Y. Lipocalin-2 deficiency attenuates insulin resistance associated with ageing and obesity. Diabetes, 59(4): 872-882, 2010.

OR-572 Liang, C.F., Au, A.L.S., Leung, S.W.S., Ng, J.K.F., Félétou, M., Kwan, Y.W.K., Man, R.Y.K.,

Vanhoutte, P.M. Endothlium-derived NO inhibits the relaxation of the porcine coronary artery to natriuretic peptides by desensitizing BKCa channels of vascular smooth muscle. J Pharmaco Exp Ther, 334: 223-231, 2010.

OR-573 Zu, Y., Liu, L., Lee, M.Y.K., Xu, C., Liang, Y., Man, R.Y., Vanhoutte, P.M., Wang, Y. SIRT1

promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells. Circulation Research, 106: 1384-1393, 2010.

OR-574 Hui, X., Li, H., Zhou, Z., Lam, K.S.L., Xiao, Y., Wu, D., Ding, K., Wang, Y., Vanhoutte, P.M.,

Xu, A. Adipocyte fatty acid binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving C-Jun N-terminal kinases and activator protein-1. J Biol Chem, 285: 10273-10280, 2010.

OR-575 Hansen, P., Hristovska A-M., Wolff, H., Vanhoutte, P., Jensen, B., Bie, P. Uridine adenosine

tetraphosphate affects contractility of mouse aorta and decreases blood pressure in conscious rats and mice. Acta Physiologica, 200: 171-179, 2010.

57

OR-576 Qu, C., Leung, S.W.S., Vanhoutte, P.M., Man, R.Y.K. Chronic inhibition of nitric-oxide synthease potentiates endothelium-dependent contractions in the rat aorta by augmenting the expression of cyclooxygenase-2. J Pharmacol Exp Ther. 334: 373-380, 2010.

OR-577 Sudano, I., Flammer, A.J., Périat, D., Enseleit, F., Hermann, M., Wolfrum, M., Hirt, A., Kaiser,

P., Hurlimann, D., Neidhart, M., Gay, S., Nussberger, J., Mocharla, P., Landmesser, U., Haile, S.R., Corti, R., Vanhoutte, P.M., Lüscher, T.M., Noll, G., Ruschitzka, R. Acetaminophen increases blood pressure in patients with coronary artery disease. Circulation, 122: 1789-1796, 2010.

OR-578 Wong, M.S.K., Delansorne, R., Svenningsen, P., Vanhoutte, P.M. Chronic treatment with

vitamin D lowers arterial blood pressure and reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol, 299: H1226-H1234, 2010.

OR-579 Chang, J., Li, Y., Huang, Y., Lam, K., Hoo, R., Wong, W.T., Cheng, K., Wang, Y., Vanhoutte, P.,

Xu, A. Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signalling pathway. Diabetes, 59: 2949-2959, 2010.

OR-580 Wong, E.S.W., Man, R.Y.K., Vanhoutte, P.M., Ng, K.F.J. Dexmedetomidine induces both

relaxations and contractions, via different α2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat. J Pharmacol Exp Ther., 335: 659-664, 2010.

OR-581 Ng, J.K.F., Leung, S.W.S., Man, R.Y.K., Vanhoutte, P.M. Endothelium-derived hyperpolarizing

factor mediated relaxations in pig coronary arteries do not involve Gi/o proteins1,2. Acta Pharmacol Sin, 29:1419-1424, 2008.

OR-582 Wong, M.S.K., Man, R.Y.K., Vanhoutte, P.M. Calcium-independent phospholipase A2 plays a

key role in the endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol, 298: H1260-H1266, 2010.

OR-583 Wong, W.T., Tian, X.Y., Chen, Y., Leung, F.P., Liu, L., Lee H.K., Ng, C.F., Xu, A., Yao, X.,

Vanhoutte, P.M., Tipoe, G.L., Huang, Y. Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation – implications on hypertension. Circ Res, 107: 984-991, 2010.

OR-584 Andersen, H., Jaff, M.G., Hogh, D., Vanhoutte, P., Hansen, P.B. Adenosine elicits an eNOS-

independent reduction in arterial blood pressure in conscious mice that involves adenosine A2A receptors. Acta Physiologica, 203: 197-207, 2011.

OR-585 Lee, M, Li, H, Xiao, Y., Zhou, Z., Xu, A., Vanhoutte, P. Chronic administration of BMS309403,

an inhibitor of adipocyte fatty acid-binding protein (A-FABP) improves endothelial function in apolipoprotein E-deficient (ApoE-/-) mice and in cultural human endothelial cells. Br J Pharm, 162: 1564-1576, 2011.

OR-586 Lin, A.H.Y., Leung, G.P.H., Leung, S.W.S., Vanhoutte, P.M., Man, R.Y.K. Genistein enhances

relaxation of the spontaneously hypertensive rat aorta by transactivation of epidermal growth factor receptor upon binding to membrane estrogen receptors-α and activation of a G protein-

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coupled, endothelial nitric oxide synthase-dependent pathway. Pharmacological Research, 63: 181-189, 2011.

OR-587 Zheng, X., Ying, L., Liu, J., Dou, D., He, Q., Leung, S.W.S., Man, R.Y.K., Vanhoutte, P.M., Gao,

Y. Role of sulfhydryl-dependent dimerization of soluble Guanylyl Cyclase in relaxation of porcine coronary artery to nitric oxide. Cardiovascul Res, 90: 565-572, 2011.

OR-588 Li, Z., Wang, Y., Vanhoutte, P.M. Epigaloocatechin gallate elicits contractions of the isolated

aorta of the aged spontaneously hypertensive rat. Basic Clin Pharmacol Toxicol, 109: 47-55, 2011.

OR-589 Chan, C.K.Y., Vanhoutte, P.M. Secretoneurin facilitates endothelium-dependent relaxations in

porcine coronary arteries. Am J Physiol Heart Circ Physiol 300: H1159-H1165, 2011. OR-590 Chan, C.K.Y., Mak, J., Gao, Y., Man, R.Y.K., Vanhoutte, P.M. Endothelium-derived NO, but

not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries. Am J Physiol Heart Circ Physiol, 301: H2313-H2321, 2011.

OR-591 Li, Z., Wang, Y., Vanhoutte, P.M. Up-regulation of Heme oxygenase-1 by hemin impairs

endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Hypertension , 58: 926-934, 2011.

OR-592 Wong, W.T., Tian, X.Y., Xu, A., Yu, J., Lau, C.W., Hoo, L.C., Wang, Y., Lee, V.W.Y., Lam,

K.S.L., Vanhoutt, P.M., Huang, Y. Adiponectin is required for PPARy-mediated improvement of endothelial function in diabetic mice. Cell Metabolism 14:104-115, 2011.

OR-593 Wu, H.J., Wu, W., Sun, H.Y., Qin, Q.W., Wang, H.B., Wang, P.W., Yalamanchili, H.K., Wang,

J.W., Tse, H.F., Lau, C.P., Vanhoutte, P.M., Li, G.R. Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain. J Mol Cell Cardio, 51: 966-973, 2011.

OR-594 Wang, Y., Cheng, K.K.Y., Lam, K.S.L., Wu, D., Wang, Y., Huang, Y., Vanhoutte, P.M.,

Sweeney, G., Li, Y., Xu, A. APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice. Diabetes, 60: 3044-3054, 2011.

OR-595 Shi, Y., Cosentino, F., Camici, G.G., Akhmedov, A., Vanhoutte, P.M., Tanner, F.C., Luscher,

T.F. Oxidized low-densitgy lipoprotein activates p66She via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-β, and c-Jun N-terminal kinase kinase in human endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 31: 2090-2097, 2011.

OR-596 Leung, J.W.C., Wong, W.T., Koon, H.W., Mo, F.M., Tam, S., Huang, Y., Vanhoutte, P.M.,

Chung, S.S.M., Chung, S.K. Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity. PLoS One, 6: 1-8, 2011.

OR-597 Dong, J., Wong, S.L., Lau, C.W., Lee, H.K., Ng, C.F., Zhang, L., Yao, X., Chen, Z.Y.,

Vanhoutte, P.M., Huang, Y. Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. European Heart Journal, published on-line, January 2012.

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OR-598 Liu, J.T.C., Song, E., Xu, A., Berger, T., Mak, T.W., Tse, H., Law, I.K.M., Huang B., Liang, Y., Vanhoutte, P.M., Wang, Y. Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition. Br J Pharmacol, 165: 520-531, 2012.

OR-599 Yang, B., Fan P., Xu, A., Lam, K.S.L., Berger, T., Mak, T.W., Tse, H.F., Yue, J.W.S., Song, E.,

Vanhoutte, P.M., Sweeney, G., Wang, Y. Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodelling. Am J Transl Res, 4: 60-71, 2012.

OR-600 Keung, W., Chan, M.L.Y., Ho, E.Y.W., Vanhoutte, P.M., Man, R.Y.K. Non-genomic activation

of adenylyl cyclase and protein kinase G by 17β-estradiol in vascular smooth muscle of the rat superior mesenteric artery. Pharmacological Research, 64: 509-516, 2011.

OR-601 Tian, X.Y., Wong, W.T., Leung, F.P., Zhang, Y., Wang, Y., Lee, H.K., Ng, C.F., Chen, Z.Y.,

Yao, X., Au, C.L., Lau, C.W., Vanhoutte, P.M., Cooke, J.P., Huang, Y. Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin F2α impairs endothelial function in renovascular hypertensive rats. Antioxidants & Redox Signaling, 16: 363-373, 2012.

OR-602 Zou, Q., Leung, S.W.S., Vanhoutte, P.M. Activation of nicotinic receptors can contribute to

endothelium-dependent relaxations to acetylcholine in the rat aorta. JPET, 341: 756-763, 2012. OR-603 Lee, M.Y.K., Cai, Y., Wang, Y., Liao, S.Y., Liu, Y., Zhang, Y., Bai, B., Tse, H.F., Vanhoutte,

P.M. Differential genomic changes caused by cholesterol- and PUFA-rich diets in regenerated porcine coronary endothelial cells. Physiological Genomics, 44: 551-561, 2012.

OR-604 Li, F.Y.L., Lam, K.S.L., Tse, H.F., Chen, C., Wang, Y., Vanhoutte, P.M., Xu, A. Endothelium-

selective activation of AMP-activated protein kinase prevents diabetes-induced impairment in vascular function and re-endothelialization via induction of Heme oxygenase-1 in mice. Circulation, 126: 1267-1277, 2012.

OR-605 Yau, K.H., Mak, J.C.W., Leung, S.W.S., Yang, D, Vanhoutte, P.M. A synthetic chloride channel

relaxes airway smooth muscle of the rat. PLOS ONE, 7: e45340, 2012. OR-606 Chan, C., Zhao, Y., Liao, S.Y., Zhang, Y.L., Lee, M., Xu, A., Tse, H.F., Vanhoutte, P.A-FABP

and oxidative stress underlie the impairment of endothelium-dependent relaxations to serotonin and the intima-medial thickening in the porcine coronary artery with regenerated endothelium. ACS Chemical Neuroscience, in press, Jan 2013.

OR-607 Qu, C., Leung, S.W.S., Vanhoutte, P.M., Man, R.Y.K. Wy14643 improves vascular function in

the aorta of the spontaneously hypertensive rat mainly by activating peroxisome proliferator-activated receptors alpha. Eur J Pharmacol, 696:101-110, 2012.

OR-608 Alkharfy, K.M., Al-Daghri, N.M., Vanhoutte, P.M., Krishnaswamy, S., Xu, A. Serum retinol-

binding protein 4 as a marker for cardiovascular disease in women. PLoS ONE 7: e48612, 2012. OR-609 Dong, J., Wong, S.L., Lau, C.W., Lee, H.K., Ng, C.F., Zhang, L., Yao, X., Chen, Z.Y.,

Vanhoutte, P.M., Huang, Y. Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. Eur Heart J, 33, 2980-2990, 2012.

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OR-610 Zhao Y, Vanhoutte, P.M., Leung, S.W.S. Endothelial nitric oxide synthase-independent release

of nitric oxide in the aorta of the spontaneously hypertensive rat. J Pharmacol Exp Ther, 344: 15-22, 2013.

OR-611 Jong, H., Mustafa, M.R., Vanhoutte, P.M., AbuBakar, S., Wong, P. MicroRNA 299-3p modulates

replicative senescence in endothelial cells. Physiol Genomics, in press, 2013. OR-612 Liang, C., Liu, J.T.C., Li, R.Y.L., Wang, Y., Xu, A., Vanhoutte, P.M. Toll-like receptor 4

Mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4. ATVB, in press, 2013.

REVIEW ARTICLES, CHAPTERS IN BOOKS AND SYMPOSIA PROCEEDINGS: R-1 Vanhoutte, P.M. De bezenuwing van hart en bloedvaten in het kader van de reflexe

bloeddrukregeling. Tijdschrift voor Geneeskunde 15: 636-644, 1967.

R-2 Vanhoutte, P.M. and Lacroix, E. De veneuze circulatie in het kader van de algemene hemodynamiek. Tijdschrift voor Geneeskunde 17: 854-858, 1969.

R-3 Vanhoutte, P.M. and Shepherd, J.T. Thermosensitivity and veins. J. Physiol. 63: 449-451, 1971. R-4 Shepherd, J.T. and Vanhoutte, P.M. Skeletal muscle blood flow-neurogenic determinants. In:

Peripheral Circulations, ed. R. Zelis. Grune and Stratton, New York, pp. 3-55, 1975. R-5 Vanhoutte, P.M. Inhibition by acetylcholine of adrenergic neurotransmission in vascular smooth

muscle. In: Physiology of Smooth Muscles, eds. E. Bulbring and M. F. Shuba. Raven Press, New York, pp. 369-377, 1976.

R-6 Vanhoutte, P.M. Physiologie et physiopathologie du système veineux. Praxis 65: 1291-1297,

1976. R-7 Vanhoutte, P.M. Cholinergic inhibition of adrenergic transmission. Fed. Proc. 36: 2444-2449,

1977. R-8 Vanhoutte, P.M. Role of changes in venular and venous diameter in circulatory control.

Bibliotheca Anatomica 16: 294-297, 1977. R-9 Janssens, W.J. and Vanhoutte, P.M. Fysiologie en fysiopathologie van het veneus stelsel.

Tijdschrift voor Geneeskunde 34: 109-118, 1978. R-10 McGrath, M.A. and Vanhoutte, P.M. Vasodilatation caused by peripheral inhibition of adrenergic

neurotransmission. In: Mechanisms of Vasodilatation, eds. P.M. Vanhoutte and I. Leusen. S. Karger, Basel, pp. 248-257, 1978.

R-11 Shepherd, J.T., Lorenz, R.R., Tyce, G.M. and Vanhoutte, P.M. Acetylcholine-inhibition of

transmitter release from adrenergic nerve terminals mediated by muscarinic receptors. Fed. Proc. 37: 191-194, 1978.

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R-12 Shepherd, J.T. and Vanhoutte, P.M. Role of the venous system in circulatory control. Mayo Clin. Proc. 53: 247-255, 1978.

R-13 Vanhoutte, P.M. Prospectives in vasodilatation: a few answers but many questions. In:

Mechanisms of vasodilatation, eds. P.M. Vanhoutte and I. Leusen. S. Karger, Basel, pp. 294-297, 1978.

R-14 Vanhoutte, P.M. Adrenergic neuroeffector interaction in the blood vessel wall. Fed. Proc. 37:

181-186, 1978. R-15 Vanhoutte, P.M. Heterogeneity of vascular smooth muscle. In: Microcirculation, eds. G. Kaley

and B.M. Altura, vol. II. University Park Press, Baltimore, pp. 181-309, 1978. R-16 Vanhoutte, P.M. Inhibition of adrenergic neurotransmission in venous smooth muscle. In:

Regulation of the Capacitance Vessels, ed. A.M. Chernuch and B. Tkachenko. Academy of Medical Sciences of the U.S.S.R. (Moscow). pp. 324-338 and Akademiai Kiado, Budapest, pp. 645-680, 1978.

R-17 Vanhoutte, P.M. and Janssens, W.J. Local control of venous function. Microvasc. Res. 16: 196-

214, 1978. R-18 Vanhoutte, P.M. and Janssens, W.J. Local control of venous function. In: Hemodynamic Changes

in Anesthesia, Proc. Vth European Congress of Anesthesiology, Paris, vol. I, pp. 423-435, 1978. R-19 Verhaeghe, R.H., Lorenz, R.R., McGrath, M.A., Shepherd, J.T. and Vanhoutte, P.M. Metabolic

modulation of neurotransmitter release-adenosine, adenine nucleotides, potassium, hyperosmolarity and hydrogen ion. Fed. Proc. 37: 208-211, 1978.

R-20 De Mey, Ch., Wellens D. and Vanhoutte, P.M. Physiopathology and pharmacotherapy of

occlusive arterial disorders. Angiology 30: 433-439, 1979. R-21 Vanhoutte, P.M., De Mey, Ch. and Wellens, D. Intermittent claudication: pathophysiological

considerations. Acta Cardiologica 34: 125-132, 1979. R-22 Vanhoutte, P.M. and Levy, M.N. Cholinergic inhibition of adrenergic neurotransmission in the

cardiovascular system. In: Integrative Functions of the Autonomic Nervous System, eds. C.McC. Brooks, K. Koizumi and A. Sato. Tokyo University Press, Tokyo, pp. 159-176, 1979.

R-23 Collis, M.G. and Vanhoutte, P.M. Alterations in vascular and neuronal reactivity during the

development of hypertension. In: Vascular Neuroeffector Mechanisms, eds. J.A. Bevan, T. Godfraind, R.A. Maxwell and P.M. Vanhoutte. Raven Press, New York, pp. 364-365, 1980.

R-24 De Mey, J.G. and Vanhoutte, P.M. Adrenergic mechanisms and apparent heterogeneity in venous

smooth muscle. In: Vascular Neuroeffector Mechanisms, eds. J.A. Bevan, T. Godfraind, R.A. Maxwell and P.M. Vanhoutte. Raven Press, New York, pp. 328-329, 1980.

R-25 Driessens, M., Mortier, G. and Vanhoutte, P.M. Vasculaire reactiviteit van het bot. Tijdschrift

voor Geneeskunde 36: 517-518, 1980.

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R-26 Shepherd, J.T. and Vanhoutte, P.M. How the heart functions. In: The American Heart Association Heart Book, the American Heart Association, pp. 127-150, 1980.

R-27 Shepherd, J.T. and Vanhoutte, P.M. Regulation of the venous system. In: First Workshop on

Peripheral Hemodynamics, ed. A.H.M. Jagenau, Janssen Research Foundation, Beerse, pp. 9-28, 1980.

R-28 Vanhoutte, P.M. Heterogeneity or homogeneity? In: Vascular Neuroeffector Mechanisms, eds.

J.A. Bevan, T. Godfraind, R.A. Maxwell and P.M. Vanhoutte. Raven Press, New York, pp. 331-332, 1980.

R-29 Vanhoutte, P.M. Physical factors and regulation of vascular smooth muscle function. In:

Handbook of Physiology: Section 2: Circulation: Volume II: Vascular Smooth Muscle, ed. D.F. Bohr, A.P. Somlyo and H.V. Sparks. The American Physiological Society, Washington, D.C., pp. 443-474, 1980.

R-30 Vanhoutte, P.M. The adrenergic neuroeffector interaction in the normotensive and hypertensive

blood vessel wall. J. Cardiovasc. Pharmacol. 2: S253-S267, 1980. R-31 Vanhoutte, P.M., De Mey, C. and Janssens, W.J. Gevoeligheid van huidbloedvaten voor

temperatuur en ziekte van Raynaud. Tijdschrift voor Geneeskunde 36: 925-928, 1980. R-32 Vanhoutte, P.M., De Mey, C., and Janssens, W.J. Thermosensibilite des vaisseaux cutanés et

maladie de Raynaud. Rev. Med. de Liege 35: 634-639, 1980. R-33 Vanhoutte, P.M. and De Mey, J.G. Fysiologie van het veneuze stelsel. In: "Perifere Circulatie en

Hartfunctie," Boerhaave Commissie, Leiden, pp. 47-58, 1980. R-34 Vanhoutte, P.M. and Janssens, W.J. Thermosensitivity of cutaneous vessels and Raynaud's

disease. Am. Heart J. 100: 263-265, 1980. R-35 Vanhoutte, P.M. and Levy, M.N. Prejunctional cholinergic modulation of adrenergic

neurotransmission in the cardiovascular system. Am. J. Physiol. 238: H275-H281, 1980. R-36 Vanhoutte, P.M. and Van Nueten, J.M. The pharmacology of lidoflazine. Proc. Royal Soc. Med.,

Congress and Symposia Series 29: 61-77, 1980. R-37 Vanhoutte, P.M., Webb, R.C. and Collis, M.G. Pre- and postjunctional adrenergic mechanisms

and hypertension. Clin. Sci. 59: 211s-223s, 1980. R-38 Van Nueten, J.M. and Vanhoutte, P.M. Improvement of tissue perfusion with inhibitors of

calcium ion influx. Biochem. Pharmacol. 29: 479-481, 1980. R-39 Burrows, M.E. and Vanhoutte, P.M. Physiopathologie de la micro-circulation et de la circulation

lymphatique. In: Physiopathologie Cardiopulmonaire, ed. H. Denolin. SIMEP, Villeurbanne, France, pp. 343-356, 1982.

R-40 De Mey, J.G., De Ridder, W. and Vanhoutte, P.M. Uneven distribution of postjunctional alpha-

adrenergic receptors and handling of Ca2+ in canine vascular smooth muscle. Proc. XXVIIIth Int.

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Congr. Physiol. Sci., Publishing House of the Hungarian Academy of Sciences, Budapest, pp. 263-268, 1981.

R-41 De Mey, J.G. and Vanhoutte, P.M. Role of Na+,K+ ATPase in the vasodilator response to

acetylcholine. In: Vasodilatation, eds. P.M. Vanhoutte and I. Leusen. Raven Press, New York, pp. 331-337, 1981.

R-42 Shepherd, J.T. and Vanhoutte, P.M. Cold vasoconstriction and cold vasodilatation. In:

Vasodilatation, eds. P.M. Vanhoutte and I. Leusen. Raven Press, New York, pp. 263-271, 1981. R-43 Shepherd, J.T. and Vanhoutte, P.M. Local modulation of adrenergic neurotransmission.

Circulation 64: 655-666, 1981. R-44 Shepherd, J.T., Vanhoutte, P.M. and Donald, D.E. Regulation of the veins by the arterial

baroreceptors. In: Arterial Baroreceptors and Hypertension, ed. P. Sleight. Oxford University Press, New York, pp. 123-129, 1980.

R-45 Vanhoutte, P.M. Les veines. In: Precis des Maladie des Vaisseaux, eds. C. Olivier and J.F.

Merlen. Masson, Paris, pp. 20-25, 1983. R-46 Vanhoutte, P.M. Local control of venous function. Proc. XXVIIIth Int. Congr. Physiol. Sci.,

Publishing House of the Hungarian Academy of Sciences, Budapest, pp. 239-246, 1981. R-47 Vanhoutte, P.M. The prejunctional and postjunctional effects of acetylcholine in the blood vessel

wall. Verhand. Kon. Akad. Geneesk. 44: 269-294, 1981. R-48 Vanhoutte, P.M. Why is acetylcholine a vasodilator? In: Vasodilatation, eds. P.M. Vanhoutte and

I. Leusen. Raven Press, New York, pp. 67-72, 1981. R-49 Vanhoutte, P.M. Calcium entry blockers and the cardiovascular system. Why calcium blockers?

Fed. Proc. 40: 2851, 1980. R-50 Vanhoutte, P.M. Calcium entry blockers and cardiovascular failure. Fed. Proc. 40: 2882-2887,

1981. R-51 Vanhoutte, P.M. Perifere hemodynamica: fysiopathologische aspekten. In: Cardiologie, ed. D.L.

Clément. Omega Editions, Gent, Belgium, pp. 426-449, 1983. R-52 Vanhoutte, P.M. Differential effects of calcium entry blockers on vascular smooth muscle. In:

New Perspectives on Calcium Antagonists, ed. G.B. Weiss. Clinical Physiology Series, The American Physiological Society, Washington, D.C., pp. 109-121, 1981.

R-53 Vanhoutte, P.M. Local regulation of smooth muscle contraction. In: Noninvasive Methods on

Cardiovascular Haemodynamics, ed. A.H.M. Jagenau. Elsevier/North Holland Biomedical Press, Amsterdam, pp. 3-20, 1981.

R-54 Vanhoutte, P.M. Pharmacology of the blood vessel wall. In: llth European Conference on

Microcirculation, ed. P. Gaeghtens. S. Karger, Basel, pp. 329-333, 1981.

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R-55 Vanhoutte, P.M. and Shepherd, J.T. Physiopathologie de la circulation veineuse. In: Physiopathologie Cardiopulmonaire, ed. H. Denolin. SIMEP, Villeurbanne, pp. 324-342, 1982.

R-56 Vanhoutte, P.M. and Shepherd, J.T. Vasodilatation due to prejunctional inhibition of adrenergic

neurotransmission. In: Modulation of Neurochemical Transmission, ed. S. Vizi. Hungarian Publishing House, Budapest, pp. 127-136, 1980.

R-57 Vanhoutte, P.M. and Shepherd, J.T. Role of the venous system in cardiovascular regulation. Proc.

XXVIIIth Int. Congr. Physiol. Sci., Publishing House of the Hungarian Academy of Sciences, Budapest, pp. 280-290, 1981.

R-58 Vanhoutte, P.M. and Van Nueten, J.M. Anoxia-induced contraction of coronary arterial smooth

muscle. Antagonism by the Ca2+ inhibitor lidoflazine. In: Coronary Spasms, ed. M.E. Bertrand. Lille, pp. 77-81, 1979.

R-59 Vanhoutte, P.M., Verbeuren, T.J. and Webb, R.C. Local modulation of the adrenergic

neuroeffector interaction in the blood vessel wall. Physiol. Rev. 61: 151-247, 1981. R-60 Van Nueten, J.M. and Vanhoutte, P.M. Calcium entry blockers and vasospasm. In:

Vasodilatation, eds. P.M. Vanhoutte and I. Leusen. Raven Press, New York, pp. 459-468, 1981. R-61 Van Nueten, J.M. and Vanhoutte, P.M. Calcium entry blockers and vascular smooth muscle

heterogeneity. Fed. Proc. 40: 2862-2865, 1981. R-62 Webb, R.C., Lockette, W.E., Vanhoutte, P.M. and Bohr, D.F. Sodium-potassium adenosine

triphosphatase and vasodilatation. In: Vasodilatation, eds. P.M. Vanhoutte and I. Leusen. Raven Press, New York, pp. 319-330, 1981.

R-63 Vanhoutte, P.M. Role of the veins in the circulation. Acta Cardiol. 36: 239-248, 1981. R-64 Vanhoutte, P.M. Physiology of the venous wall. Medicographia 2: 8-12, 1980. R-65 Vanhoutte, P.M. Release and disposition of norepinephrine in the blood vessel wall of the

spontaneously hypertensive rat. In: New Trends in Arterial Hypertension, eds. M. Worcel, et al. Elsevier/North-Holland Biomedical Press, pp. 3-10, 1981.

R-66 Vanhoutte, P.M. Introductory remarks: Pharmacology of the blood vessel wall. J. Cardiovasc.

Pharmacol. 3: 1359-1369, 1981. R-67 Burrows, M.E. and Vanhoutte, P.M. Pharmacology of arterioles: some aspects of variability in

response to norepinephrine, histamine and 5-hydroxytryptamine. J. Cardiovasc. Pharmacol. 3: 1370-1380, 1981.

R-68 Vanhoutte, P.M. Introductory remarks: Alpha- and beta-adrenergic receptors and the

cardiovascular system. J. Cardiovasc. Pharmacol. 3: Sl-S13, 1981. R-69 Vanhoutte, P.M. Heterogeneity of postjunctional vascular -adrenoceptors and handling of

calcium. J. Cardiovasc. Pharmacol. 4: S91-S96, 1982.

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R-70 Van Nueten, J.M., Janssen, P.A.J. and Vanhoutte, P.M. Pharmacological properties of serotonergic responses in vascular, bronchial and gastrointestinal smooth muscle. In: Vascular Neuroeffectors, eds. J.A. Bevan, et al. Raven Press, New York, pp. 243-250, 1983.

R-71 Collis, M.G. and Vanhoutte, P.M. Vascular reactivity and neurotransmitter release in

experimental hypertension. Proceedings, International Symposium, Cellular Handling of Ions, Transmitter Release, Smooth Muscle Contractility and Hypertension, ed. Searle, Stenungsund, Sweden., pp. 27-29, 1983.

R-72 Vanhoutte, P.M. 5-Hydroxytryptamine, vasospasm and hypertension. In: 5-Hydroxytryptamine in

Peripheral Reactions, eds. F. De Clerck and P.M. Vanhoutte. Raven Press, New York, pp. 163-174, 1982.

R-73 Vanhoutte, P.M. Control of vascular function: role of the non-muscle components. Mayo Clin.

Proc. 57: 20-27, 1982. R-74 Vanhoutte, P.M. and Verbeuren, T.J. Effects of buflomedil on the blood vessel wall. In:

Microcirculation and Ischemic Vascular Diseases. Clinical and Therapeutic Approaches, ed. S. Kornfeind. Biomedical Information Corporation, New York, pp. 465-474, 1982.

R-76 Vanhoutte, P.M. Calcium entry blockers and vascular smooth muscle. Circulation 65: I-11-I-19,

1982. R-77 Vanhoutte, P.M. and Levy, M.N. Prejunctional cholinergic modulation on adrenergic

neurotransmission and the cardiovascular system. In: Excitation and Neural Control of the Heart, eds. M.N. Levy and M. Vassalle. The American Physiological Society, pp. 243-255, 1982.

R-78 Vanhoutte, P.M. Are there haemorheological reasons for using drugs acting on vascular smooth

muscle? Clinical Hemorrheology. 2: 299-303, 1982. R-79 Vanhoutte, P.M. and Shepherd, J.T. Autonomic nerves to the systemic blood vessels. In:

Peripheral Neuropathy, eds. P.J. Dyck, P.K. Thomas, E. Lambert and R. Bunge. W. B. Saunders Co., Philadelphia, pp. 301-326, 1984.

R-80 Vanhoutte, P.M. Does 5-hydroxytryptamine play a role in hypertension? Tr. Pharmacol. Sci. 3:

370-373, 1982. R-81 Vanhoutte, P.M. Beta-adrenergic blocking drugs, adrenergic neuroeffector interaction and

systemic vascular resistance. In: Advances in Beta-Blocker Therapy II, Proceedings of the 2nd International Symposium, ed. A. Zanchetti. Excerpta Medica, Amsterdam, pp. 279-289, 1982.

R-82 Van Nueten, J.M., Leysen, J.E., Vanhoutte, P.M. and Janssen, P.A.J. Serotonergic responses in

vascular and non-vascular tissue. Arch. Int. Pharmacodyn. Ther. 256: 331-334, 1982. R-83 Shepherd, J.T., Rusch, N.J. and Vanhoutte, P.M. Effect of cold on the blood vessel wall. Gener.

Pharmacol. 14: 61-64, 1983. R-84 Vanhoutte, P.M. and De Mey, J.T. Control of vascular smooth muscle function by the endothelial

cells. Gener. Pharmacol. 14: 39-41, 1983.

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R-85 Vanhoutte, P.M. and Shepherd, J.T. Muscarinic and -adrenergic prejunctional modulation of adrenergic neurotransmission in the blood vessel wall. Gener. Pharmacol. 14: 35-37, 1983.

R-86 Vanhoutte, P.M. Effects of calcium entry blockers on tissue hypoxia. J. Cerebral Blood Flow

Metab. 2: S42-S44, 1982. R-87 Vanhoutte, P.M. Hyperreactivity of the blood vessel wall in hypertension. In: Cardiology, Vol. 1.

Hypertension, eds. P. Sleight and E. Freis. Butterworth and Co., Ltd., England, pp. 216-228, 1982.

R-88 Vanhoutte, P.M. Hypoxia and tissue perfusion. In: Cerebral Hypoxia in the Pathogenesis of

Migraine, eds. F.C. Rose and W.K. Amery. Pitman Press, Great Britain, pp. 3-11, 1982. R-89 Vanhoutte, P.M. and Van Nueten, J.M. Lidoflazine. In: New Drugs Annual: Cardiovascular

Drugs, ed. A. Scriabine. Raven Press, New York, pp. 203-226, 1983. R-90 Vanhoutte, P.M. Why 5-hydroxytryptamine? Fed. Proc. 42: 211-212, 1983. R-91 Vanhoutte, P.M. 5-Hydroxytryptamine and vascular disease. Fed. Proc. 42: 233-237, 1983. R-92 Vanhoutte, P.M., Van Nueten, J.M., Symoens, J. and Janssen, P.A.J. Antihypertensive properties

of ketanserin (R 41 468). Fed. Proc. 42: 182-185, 1983. R-93 Vanhoutte, P.M. Cinnarizine, flunarizine, lidoflazine. In: Calcium Modulators, eds. T. Godfraind,

A. Albertini and R. Paoletti. Elsevier Biomedical Press, Amsterdam, pp. 351-362, 1982. R-94 Vanhoutte, P.M. and Rimele, T.J. Effects of calcium entry blockers on isolated blood vessels.

Prog. Pharmacol. 5: 23-36, 1983. R-95 Vanhoutte, P.M. Adjustments in the peripheral circulation in chronic heart failure. Eur. Heart J. 4:

67-83, 1983. R-96 Van Nueten, J.M., Leysen, J.E., Schuurkes, J.A.J. and Vanhoutte, P.M. Ketanserin: a selective

antagonist of 5-HT2 serotonergic receptors. The Lancet, February 5, pp. 297-298, 1983. R-97 Vanhoutte, P.M. and Van Nueten, J.M. Ketanserin - a novel antihypertensive drug. J. Pharm.

Pharmacol. 35: 339-340, 1983. R-98 Vanhoutte, P.M., Rimele, T.J. and Van Nueten, J.M. Calcium entry blockers and contractile

responses of vascular smooth muscle. Calcium Antagonists: The State of the Art and Role in Cardiovascular Disease. Symp. Front. Pharmacol. 2: 65-75, 1983.

R-99 Vanhoutte, P.M. Role of the endothelium in control of vascular smooth muscle function. Verh.

Kon. Akad. Geneesk. 44: 411-418, 1982. R-100 Vanhoutte, P.M. and Rimele, T.J. Role of the endothelium in the control of vascular smooth

muscle function. J. Physiol. 78: 681-686, 1983. R-101 Vanhoutte, P.M. and Cohen, R.A. The elusory role of serotonin in vascular function and disease.

Biochem. Pharmacol. 32: 3671-3674, 1983.

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R-102 Vanhoutte, P.M. Hypoxia, tissue perfusion and potential role of vasodilator drugs. Symp. Front.

Pharmacol. 3: 97-102, 1983. R-103 Vanhoutte, P.M. Buflomedil. In: New Drug Annual: Cardiovascular Drugs, ed. A. Scriabine,

Raven Press, New York, pp. 211-224, 1984. R-104 Vanhoutte, P.M. and Rimele, T.J. Control of vascular smooth muscle function. Int. Angiology 3:

17-30, 1984. R-105 Vanhoutte, P.M. and Cohen, R.A. Calcium entry blockers and cardiovascular disease. Am. J.

Cardiol. 52: 99A-103A, 1983. R-106 Cohen, R.A., Shepherd, J.T and Vanhoutte, P.M. Vasodilatation mediated by the coronary

endothelium in response to aggregating platelets. In: Vasodilator Mechanisms, eds. P.M. Vanhoutte and S.F. Vatner, Karger, Basel, pp. 35-42, 1984.

R-107 Vanhoutte, P.M. The cardiovascular pharmacology of buflomedil. In: Vasodilator Mechanisms.

eds. P.M. Vanhoutte and S.F. Vatner, Karger, Basel, pp. 209-221, 1984. R-108 Van Nueten, J.M. and Vanhoutte, P.M. Cardiovascular pharmacology of ketanserin. In:

Vasodilator Mechanisms, eds. P.M. Vanhoutte and S.F. Vatner, Karger, Basel, pp. 222-233, 1984. R-109 Vanhoutte, P.M. and Lorenz, R.R. Na+,K+-ATPase inhibitors and the adrenergic neuroeffector

interaction in the blood vessel wall. J. Cardiovasc. Pharmacol. 6: S88-S94, 1984. R-110 Shepherd, J.T. and Vanhoutte, P.M. Why nerves to coronary vessels? Fed. Proc. 43: 2855-2861,

1984. R-111 Cohen, R.A., Shepherd, J.T. and Vanhoutte, P.M. Effects of the adrenergic transmitter on

epicardial coronary arteries. Fed. Proc. 43: 2862-2866, 1984. R-112 Vanhoutte, P.M. and Cohen, R.A. Effects of acetylcholine on the coronary artery. Fed. Proc. 43:

2878-2880, 1984. R-113 Vanhoutte, P.M., Rimele, T.J. and Rooke, T.W. Calcium entry and the contraction of vascular

smooth muscle. In: Advances in Cyclic Nucleotide and Protein Phosphorylation Research, vol. 17, eds. P. Greengard, A. Robison, R. Paoletti and Nicosa. Raven Press, New York, pp 569-573, 1984.

R-114 Vanhoutte, P.M. Autonomic nerves, aggregating platelets and contraction of coronary arterial

smooth muscle. In: Functional Aspects of the Normal, Hypertrophied and Failing Heart, eds. F.L. Abel and W.H. Newman. Martinez-Nijhoff, Hingam, MA, pp. 135-148, 1984.

R-115 Vanhoutte, P.M. Rôle de l'endothelium dans le fonctionnement des fibres vasculaires. J.

Pharmacol. 14: 73-79, 1983. R-116 Vanhoutte, P.M., Cohen, R.A. and Van Nueten, J.M. Serotonin and arterial vessels. J. Cardiovasc.

Pharmacol. 6: S421-S428, 1984. R-117 Vanhoutte, P.M. Control of venous function. Int. Angiol. 3: 40-46, 1984.

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R-118 Vanhoutte, P.M. and Miller, V.M. Heterogeneity of endothelium-dependent responses in

mammalian blood vessels. J. Cardiovasc. Pharmacol. 7: S12-S23, 1985. R-119 Vanhoutte, P.M. Calcium entry blockers in vascular disease. Int. Angiology 3: 5-7, 1984. R-120 Rimele, T.J and Vanhoutte, P.M. Differential effects of calcium entry blockers on vascular

smooth muscle. Int. Angiology 3: 17-23, 1984. R-121 Van Nueten, J.M. and Vanhoutte, P.M. Serotonin and vascular function. Clinics in

Anesthesiology 2: 363-382, 1984. R-122 Vanhoutte, P.M. and McGoon, M.D. The endothelial cell. In: Abnormal Pulmonary Circulation,

ed. E.H. Bergofsky, Churchill-Livingstone, New York, 1986. R-123 Vanhoutte, P.M. The role of serotonin in hypertension Clinical implications for the use of

serotonin antagonists. Drug Therapy, pp. 111-126, June, 1984. R-124 Vanhoutte, P.M. Why are Ca2+ entry blockers effective in the treatment of hypertension and

tissue hypoxia? In: Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions, eds. T. Godfraind, A.G. Herman, and D. Wellens. Martinus Nijhoff Publishers, The Hague, Netherlands, pp. 307-312, 1984.

R-125 Vanhoutte, P.M. and Shepherd, J.T. Adrenergic pharmacology of human and canine peripheral

veins. Fed. Proc. 44: 337-340, 1985. R-126 Vanhoutte, P.M. Calcium-entry blockers, vascular smooth muscle and systemic hypertension.

Am. J. Cardiol. 55: 17B-23B, 1985. R-127 Vanhoutte P.M. and Cooke, J.P. Vascular responsiveness in hypertension. In: Clinical Medicine,

eds. J.A. Spittell and S. Sheps. J.B. Lippincott Company, Philadelphia, pp. 1-13, 1985. R-128 Marcelon, G. and Vanhoutte, P.M. Mechanism of action of ruscus extract. Internat. Angiol. 3: 74-

76, 1984. R-129 Van Nueten, J.M. and Vanhoutte, P.M. Flunarizine. In: New Drugs Annual: Cardiovascular

Drugs, ed. A. Scriabine. Raven Press, New York, pp. 245-266, 1984. R-130 Shepherd, J.T. and Vanhoutte, P.M. Spasm of the coronary arteries: Causes and consequences

(the scientist's viewpoint). Mayo Clin. Proc. 60: 33-46, 1985. R-131 Vanhoutte, P.M. Calcium entry blockers and peripheral vascular disease. In: Calcium Entry

Blockers and Tissue Protection, eds. T. Godfraind, P.M. Vanhoutte, S. Govoni and R. Paoletti. Raven Press, New York, pp. 195-202, 1985.

R-132 Flavahan, N.A. and Vanhoutte, P.M. The respiratory epithelium releases a smooth muscle

relaxing factor. Chest 87: 189S-190S, 1985. R-133 Cohen, R.A. and Vanhoutte, P.M. Platelets, serotonin, and endothelial cells. In: Serotonin and the

Cardiovascular System, ed. P.M. Vanhoutte. Raven Press, New York, pp. 105-112, 1985.

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R-134 Webb, R.C. and Vanhoutte, P.M. Responsiveness of the hypertensive blood vessel wall to

serotonergic stimuli. In: Serotonin and the Cardiovascular System, ed. P.M. Vanhoutte. Raven Press, New York, pp. 113-122, 1985.

R-135 Vanhoutte, P.M. Peripheral serotonergic receptors and hypertension. In: Serotonin and the

Cardiovascular System, ed. P.M. Vanhoutte. Raven Press, New York, pp. 123-134, 1985. R-136 Van Nueten, J.M., Janssens, W.J. and Vanhoutte, P.M. Serotonin and vascular smooth muscle. In:

Serotonin and the Cardiovascular System, ed. P.M. Vanhoutte. Raven Press, New York, pp. 95-104, 1985.

R-137 Vanhoutte, P.M., Katusic, Z.S. and Shepherd, J.T. Vasopressin induces endothelium-dependent relaxations of cerebral and coronary, but not of systemic arteries. J. Hypertens. 2: 421-422, 1984.

R-138 Vanhoutte, P.M. Can peripheral serotonergic blockade explain the hypotensive effect of

ketanserin? J. Cardiovasc. Pharmacol. 7: SI05-S109, 1985. R-139 Van Nueten, J.M., Leysen, J.E., de Clerck, F. and Vanhoutte, P.M. Serotonergic receptor subtypes

and vascular reactivity. J. Cardiovasc. Pharmacol. 6: S564-S574, 1984. R-140 Shepherd, J.T. and Vanhoutte, P.M. Circulation in tissues with obstructive arterial disease. In:

Calcium Entry Blockers and Tissue Protection, eds. T. Godfraind, P.M. Vanhoutte, S. Govoni and R. Paoletti. Raven Press. New York, pp. 107-116. 1985.

R-141 Symoens, J. and Vanhoutte, P.M. Role of serotonin in blood pressure regulation. In: Care of the

Postoperative Patient, ed. J.A.R. Smith and J. Watkins. Butterworth, Kent, pp. 141-164, 1985. R-142 Vanhoutte, P.M. Vasodilator and vasoconstrictor signals generated by the endothelium. In: The

Peripheral Circulation, eds. S. Hunyor, J. Ludbrook, J. Shaw and M. McGrath. Elsevier Science Publishers, Amsterdam, pp. 3-8, 1984.

R-143 Vanhoutte, P.M., Rimele, T.J. and Flavahan, N.A. Lipoxygenase and calcium entry in vascular

smooth muscle. J. Cardiovasc. Pharmacol. 7: S47-S52, 1985. R-144 Shepherd, J.T. and Vanhoutte, P.M. The sensory systems involved in cardiovascular regulation.

Chapter 7, In: Mayo Clinic Textbook of Cardiology, eds. R.0. Brandenburg, V. Fuster, E.R. Giuliani and D.C. McGoon. Year Book Medical Publishers, pp. 164-182, 1986.

R-145 Shepherd, J.T. and Vanhoutte, P.M. Local modulation of adrenergic neurotransmission in blood

vessels. J. Cardiovasc. Pharmacol. 7: S167-S178, 1985. R-146 Vanhoutte, P.M. Autonomic nerves, endothelium, aggregating platelets and contraction of

coronary arterial smooth muscle. In: Vascular Neuroeffector Mechanisms, eds. J.A. Bevan, et al. Elsevier Science Publishers, Amsterdam, pp. 205-210, 1985.

R-147 Vanhoutte, P.M. Serotonin and hypertension. In: Vascular Neuroeffector Mechanism, eds. J.A.

Bevan, et al. Elsevier Science Publishers, Amsterdam, pp. 329-332, 1985. R-148 Vanhoutte, P.M. and Houston, D.S. Platelets, endothelium and vasospasm. Circulation 72: 728-

734, 1985.

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R-149 Vanhoutte, P.M. Serotonin, adrenergic nerves, endothelial cells and vascular smooth muscle. In:

Progress in Applied Microcirculation, Vol. 10, Serotonin and Microcirculation. Karger, Basel, pp. 1-11, 1986.

R-150 Shepherd, J.T. and Vanhoutte, P.M. Regulation of the circulation to skin and muscle in the limbs.

In: "Conservative Therapy on Arterial Occlusive Disease", ed. G.T. Verlag, Stuttgart-New York, pp. 3-9, 1986.

R-151 Vanhoutte, P.M. and Lüscher, T.F. Serotonin and the blood vessel wall. J. Hypertens. 4: S29-S35,

1986. R-152 Vanhoutte, P.M., Rubanyi, G.M., Miller, V.M. and Houston, D.S. Modulation of vascular smooth

muscle contraction by the endothelium. Ann. Rev. Physiol. 48: 307-320, 1986. R-153 Vanhoutte, P.M. and Flavahan, N.A. Effects of temperature on alpha-adrenoceptors in limb veins.

Role of receptor reserve. Fed. Proc. 45: 2347-2354, 1986. R-154 Vanhoutte, P.M. Could the absence or malfunction of vascular endothelium precipitate the

occurrence of vasospasm? J. Mol. Cell. Cardiol. 18: 679-689, 1986. R-155 Van Nueten, J.M., Janssens, W.J. and Vanhoutte, P.M. Serotonin and vascular reactivity.

Pharmacol. Res. Comm. 17: 585-608, 1985. R-156 Houston, D.S. and Vanhoutte, P.M. Serotonin and the vascular system. Role in health and disease

and implications for therapy. Drugs 3: 149-163, 1986. R-157 Vanhoutte, P.M. Ca2+ entry blockers: What are they and on which cells do they act? J. Cerebral

Blood Flow Metab. 5: S327-S328, 1985. R-158 Rorie, D.K., Rubanyi, G.M. and Vanhoutte, P.M. Anatomy and physiology of the coronary

arteries. In: Anesthesia and Coronary Artery Surgery, ed. S. Tarhan. Year Book Medical Publishers, Inc., Chicago, pp. 1-23, 1986.

R-159 Vanhoutte, P.M., Ball, S.G., Berdeaux, A., Cohen, M.L., Hedner, T., McCall, R., Ramage, A.G.,

Reimann, I.H., Richer, C., Saxena, P.R., Schalekamp, M.A.H.D., Struyker-Boudier, H.A.J., Symoens, J., Van Nueten, J.M. and van Zwieten, P.A. Mechanism of action of ketanserin in hypertension. Tr. Pharmac. Sci. 7: 58-59, 1986.

R-160 Vanhoutte, P.M. and Flavahan, N.A. The heterogeneity of adrenergic receptors: Chairman's

comments. In: Pharmacology of Adrenoceptors, eds. E. Szabadi, C.M. Bradshaw and S.R. Nahorski. Macmillan Press, Ltd., London, pp. 43-46, 1986.

R-161 Vanhoutte, P.M. and Lüscher, T.F. Peripheral mechanisms in cardiovascular regulation:

Transmitters, receptors and the endothelium. In: Handbook of Hypertension: Section on Physiology and Pathophysiology of Hypertension, eds. R.C. Tarazi and A. Zanchetti. Elsevier Science Publishers B.V., Amsterdam, pp. 96-123, 1986.

R-162 Vanhoutte, P.M. Serotonin-antagonisten. Der Informierte Arzt 3: 42-48, 1986.

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R-163 Vanhoutte, P.M. and Flavahan, N.A. Temperature and adrenergic activation of cutaneous veins. In: Progress in Angiology, eds. P. Balas and A. Schirger. Edizioni Minerva Medica, Italy, pp. 209-216, 1986.

R-164 Vanhoutte, P.M. and Katusic, Z.S. Endothelium-dependent responses in cerebral blood vessels.

In: Neural Regulation of Brain Circulation, eds. Ch. Owman and J.E. Hardebo. Elsevier Science Publishers B.V., pp. 19-25, 1986.

R-165 Vanhoutte, P.M. Alpha-adrenergic effects of Ruscus aculeatus on cutaneous veins. Modulation

by local temperature. In: Advances in Medical Phytochemistry:I, eds. D. Barton and W.D. Ellis. John Libbey, London, pp. 187-194, 1986.

R-166 Vanhoutte, P.M. and Shepherd, R.F. Serotonin, serotonergic antagonists and hypertension. In:

Primary Hypertension, eds. W. Kaufmann, et al. Springer-Verlag, New York, pp. 210-224, 1986. R-167 Shepherd, J.T. and Vanhoutte, P.M. Mechanisms responsible for coronary vasospasm. J. Am.

Coll. Cardiol. 8: 50A-54A, 1986. R-168 Flavahan, N.A. and Vanhoutte, P.M. Alpha1-adrenoceptor subclassification in vascular smooth

muscle. Tr. Pharmacol. Sci. 7: 347-349, 1986. R-169 Vanhoutte, P.M. and Houston, D.S. Serotonin, platelets and vascular function. In: Central and

Peripheral Mechanisms of Cardiovascular Regulation, eds. A. Magro, W. Osswald, D. Reis and P. Vanhoutte. Plenum Press, New York and London, pp. 135-161, 1986.

R-170 Marcelon, G., Balanant, Y., Pouget, G., Sablayrolles, S., Tisne-Versailles, J. and Vanhoutte, P.M.

Warming augments the pharmacological displacement of norepinephrine caused by ruscus in cutaneous veins. In: What is New in Angiology?, eds. P.C. Maurer, H.M. Becker, H. Heidrich, G. Hoffmann, A. Kriessmann, H. Muller-Wiefel and C. Pratorius. W. Zuckschwerdt Verlag Munchen, pp. 240-241, 1986.

R-171 Vanhoutte, P.M. Endothélium et réactivité artérielle. J. des Maladies Vaculaires 11: 213-221,

1986. R-172 Vanhoutte, P.M. Kardiovaskulare Pharmakologie von Buflomedil. In: Makro und

Mikrozirkulation bei ischämischer Verschlusskrankheiten, eds. K. Messmer. W. Zuckschwerdt Verlag, Munchen, pp. 1-5, 1986.

R-173 Marcelon, G., Sales V. and Vanhoutte, P.M. Potentialisation, sous l'effet de la chaleur, de

l'activite veinotonique de l'extrait de Ruscus aculeatus. In: Phlebology, eds. D. Negus and G. Jantet. John Libbey, London and Paris, pp. 886-889, 1985.

R-174 Vanhoutte, P.M. Platelets, endothelium, vasospasm and atherosclerosis. In: Les medicaments de

l'athérosclérose, eds. P. Meyer and J.C. Gilbert. Masson, Paris, pp. 105-121, 1986. R-175 Vanhoutte, P.M. Peripheral adrenergic transmission and hypertension. Medicographia 8: 9-11,

1986. R-176 Vanhoutte, P.M. Serotonin and the vascular wall. Int. J. Cardiol. 14: 189-203, 1987.

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R-177 Vanhoutte, P.M. Endothelium and the control of vascular tissue. News in Physiol. Sci. 2: 18-22, 1987.

R-178 Vanhoutte, P.M. Serotonin and the blood vessel wall. J. Hypertens. 4: Sl12-S115, 1986. R-179 Vanhoutte, P.M. Possible pharmacological approaches to the treatment of peripheral vascular

disease. In: Vascular Diseases, eds. E. Strandness, P. Didisheim, A. Clowes and J. Watson, Grune and Stratton, Orlando, FL, pp. 151-182, 1987.

R-180 Vanhoutte, P.M. and Paoletti, R. Classification of calcium-antagonists: The viewpoint of the

expert committee of the WHO. Trends in Pharmacol. Sci., 8: 4-5, 1987. R-181 Vanhoutte, P.M. Airway epithelium and bronchial reactivity. Can. J. Physiol. & Pharmacol. 65:

448-450, 1987. R-182 Vanhoutte, P.M. Endothelium-dependent contractions in arteries and veins. Blood Vessels 24:

141-144, 1987. R-183 Vanhoutte, P.M. and Shepherd, J.T. Pharmacology of large coronary arteries. Chapter 38.C, In:

Cardiology: Fundamentals and Practice Volume 1, eds R.0. Brandenburg, V. Fuster, E. R. Giuliani and D.C. McGoon, Year Book Medical Publishers, Inc., Chicago, pp. 1061-1072, 1986.

R-184 Vanhoutte, P.M. Endothelium-dependent contractions in veins and arteries. Chapter 2, In:

Relaxing and Contracting Factors: Biological and Clinical Research, ed. P.M. Vanhoutte, Humana Press, Clifton, N.J., pp. 27-39, 1988.

R-185 Rubanyi, G.M. and Vanhoutte, P.M. Modulation of the release and biological activity of

endothelium-derived relaxing factor by oxygen-derived free radicals. Chapter 5, In: Relaxing and Contracting Factors: Biological and Clinical Research, ed. P.M. Vanhoutte, Humana Press, Clifton, N.J., pp. 91-105, 1988.

R-186 Rubanyi, G.M., Schwartz, A. and Vanhoutte, P.M. Calcium transport mechanisms in endothelial

cells regulating the synthesis and release of endothelium-derived relaxing factor. Chapter 9, In: Relaxing and Contracting Factors: Biological and Clinical Research, ed. P.M. Vanhoutte, Humana Press, Clifton, N.J., pp. 179-188, 1988.

R-187 Miller, V.M. and Vanhoutte, P.M. Heterogeneity in endothelium-dependent relaxations: acute,

chronic and evolutionary modulations. Chapter 14, In: Relaxing and Contracting Factors: Biological and Clinical Research, ed. P.M. Vanhoutte, Humana Press. Clifton, N.J., pp. 285-307, 1988.

R-188 Houston, D.S. and Vanhoutte, P.M. Platelets and endothelium-dependent responses. Chapter 21,

In:, Relaxing and Contracting Factors: Biological and Clinical Research, ed. P.M. Vanhoutte. Humana Press, Clifton, N.J., pp. 425-449, 1988.

R-189 Lüscher, T.F. and Vanhoutte, P.M. Mechanisms of altered endothelium-dependent responses in

hypertensive blood vessels. Chapter 24. In: Relaxing and Contracting Factors: Biological and Clinical Research, ed. P.M. Vanhoutte, Humana Press, Clifton, N.J., pp. 495-509, 1988.

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R-190 Johnson, J.M., Brengelmann, G.L., Hales, J.R.S., Vanhoutte, P.M. and Wenger, C.B. Regulation of the cutaneous circulation, Fed. Proc., 45: 2841-2850, 1986.

R-191 Vanhoutte, P.M. The Expert Committee of the World Health Organization on Classification of

Calcium Antagonists: The viewpoint of the rapporteur. Am. J. Cardiol. 59: 3A-8A, 1987. R-192 Shepherd, J.T. and Vanhoutte, P.M. The circulation in the limbs: normal function and effects of

disease. In: Handbook of Cardiology, eds. W. Parmley and Chatterjee, J. B. Lippincott Company, Philadelphia, 1987.

R-193 Shepherd, J.T. and Vanhoutte, P.M. The sensory systems involved in cardiovascular regulation. In: Cardiology Fundamentals and Practice, eds. R. 0. Brandenberg, V. Fuster, E. R. Giuliani and D. C. McGoon. Year Book Medical Publishers, Inc., Chicago-London, pp. 164-182, 1987.

R-194 Vanhoutte, P.M. Ca2+-antagonists: What are they and what do they do? Actual. Chim. Ther. 14:

119-123, 1987. R-195 Flavahan, N.A. and Vanhoutte, P.M. Receptor-reserve and heterogeneity of vascular responses to

vasodilator stimuli. Chapter on Catecholamines In: Vasodilatation: Vascular Smooth Muscle Peptides, Autonomic Nerves, and Endothelium, ed. P.M. Vanhoutte. Raven Press, New York, pp. 201-210, 1988.

R-196 Vanhoutte, P.M. and Zander, J.F. Vascular pharmacology of naftidorfuryl. In: Vasodilatation, ed.

P.M. Vanhoutte. Raven Press, New York, pp. 281-288, 1988. R-197 Vanhoutte, P.M. and Boulanger, C.M. Endothélium et réactivité vasculaire. Comm. Cell. &

Pathol. 10: 49-53, 1988. R-198 Lüscher, T.F. and Vanhoutte, P.M. Hypertension and endothelium-dependent responses. In:

Vasodilatation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium, ed. P.M. Vanhoutte. Raven Press, New York, pp. 523-529, 1988.

R-199 Flavahan, N.A. and Vanhoutte, P.M. Heterogeneity of alpha-adrenergic responsiveness in

vascular smooth muscle: role of receptor subtypes and receptor reserve. In: The Alpha-1 Adrenergic Receptors, ed. R. Ruffolo. Humana Press, New Jersey, pp 351-403, 1987.

R-200 Vanhoutte, P.M. and Flavahan, N.A. "Modulation of Cholinergic Neurotransmission in the

Airways", In: The Airways: Neural Control in Health and Disease, eds. Kaliner and P.Barnes, New York, pp. 203-216, 1987.

R-201 Vanhoutte, P.M. The role of the systemic veins. An update. Phlebology 2: 61-73, 1987. R-202 Vanhoutte, P.M., Amery, A., Birkenhager, W., Breckenridge, A., Buhler, F., Distler, A.,

Dormandy, J., Doyle, A., Frohlich, E., Hansson, L., Hedner, T., Hollenberg, N., Jensen H., Lund-Johansen, P., Meyer, P., Opie, L., Robertson, I., Safar, M., Schalekamp, M., Symoens, J., Trap-Jensen, J. and Zanchetti, A. Serotonergic mechanisms in hypertension: focus on the effects of ketanserin. Hypertension 11: 111-133, 1988.

R-203 Vanhoutte, P.M. Interviene la 5-hidroxitriptamina (serotonina) en la hipertension? Hipertension 3:

22-28, 1984.

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R-204 Vanhoutte, P.M. Kardiovaskulare pharmakologie von buflomedil. In: Makro- und Mikrozirkulation bei ischamischer verschlusskrankheit, K. Messmer, ed. W. Zuckschwerdt Verlag, Munich, pp 3-11, 1987.

R-205 Flavahan, N.A. and Vanhoutte, P.M. -1-Adrenoceptor subclassification in vascular smooth

muscle. A premature proposal? (Flavahan and Vanhoutte reply.) Trends in Pharmacol. Sci. 8: 124-125, 1987.

R-206 Vanhoutte, P.M. and Lüscher, T.F. Vascular endothelium and hypertension. J. Cardiovasc.

Pharmacol. 10: S19-S24, 1987. R-207 Vanhoutte, P.M. Ca2+antagonists and vascular disease. Ann. N.Y. Acad. Sci. 552: 380-389,

1988. R-208 Vanhoutte, P.M. The end of a quest? Nature 327: 459-460, 1987. R-209 Van Nueten, J.M., Janssen, P.A., Symoens, J., Janssens, W.J., Heykants, J., De Clerck, F.,

Leysen, J.E., Vancauteren, H. and Vanhoutte, P.M. Ketanserin. In: New Cardiovascular Drugs 1987, ed. A. Scriabine, New York, Raven Press, pp. 1-56, 1987.

R-210 Vanhoutte, P.M. Cardiovascular effects of serotonin. J. Cardiovasc. Pharmacol. 10: S8-S11, 1987. R-211 Vanhoutte, P.M. Interactions between nerves, smooth muscle and endothelium in vascular

responses. In: Neuronal Messengers in Vascular Function, eds. A. Nobin, C. Owman and B. Arnecklo-Nobin, Amsterdam, Elsevier Science Publishers, pp. 295-304, 1987.

R-212 Shepherd, R.J.F. and Vanhoutte, P.M. Mechanisms of coronary artery spasm. Cardiol. 4: 46-

48,76; 1987. R-213 Rubanyi, G.M. and Vanhoutte, P.M. Calcium and Activation of the Release of Endothelium-

derived Relaxing Factor. Proc. N.Y. Acad. Sci. 552: 226-233, 1988. R-214 Lüscher, T.F., Raij, L. and Vanhoutte, P.M. Effect of hypertension and its reversal on

endothelium-dependent relaxations in the aorta of the rat. J. Hypertens. 5: S153-S155, 1987. R-215 Vanhoutte, P.M. State of the Art Lecture: Endothelium and responsiveness of vascular smooth

muscle. J Hypertens. 5: S115-S120, 1987. R-216 Moncada, S., Herman, A.G. and Vanhoutte, P.M. Endothelium-derived relaxing factor (EDRF) is

identified as nitric oxide. Trends in Pharmacol. Sci. 8: 365-368, 1987. R-217 Vanhoutte, P.M. Platelets, endothelium and blood vessel wall. Experientia 44:105-109, 1988. R-218 Flavahan, N.A. and Vanhoutte, P.M. Thermosensitivity of cutaneous and deep veins. Phlebology

3: 41-45, 1988. R-219 Shepherd, J.T., Coffman, J.D., Lassen, N.A., Lindblad, L.E., Mellstrand, T., Norgren, L.,

Vanhoutte, P.M. and Van Nueten, J.M. Panel discussion: Has transmitter interaction physiological or pathophysiological relevance in human vascular function? In: Neuronal

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Messengers in Vascular Function. eds A. Nobin, C. Owman and B. Arneklo-Nobin. Elsevier Science Publishers (Biomedical Division), Amsterdam, pp. 557-567, 1987.

R-220 Opie, L.H., Buhler, F.R., Fleckenstein, A., Hansson, L., Harrison, D.C., Poole-Wilson, P.A.,

Schwartz, A. and Vanhoutte, P.M. in consultation with Braunwald, E., Nayler, W.G., Paoletti, R., Contin, C.R., Rapaport, E., Godfraind, T., Snyder, S.H. and Kubler, W. International Society and Federation of Cardiology: Working Group on Classification of Calcium Antagonists for Cardiovascular Disease (editorial). Am. J Cardiol. 60: 630-632, 1987.

R-221 Vanhoutte, P.M. and Bühler, F.R. Links and interactions between alpha-adrenergic and

serotonergic receptors. J. Cardiovasc. Pharmacol. 11: v-vi, 1988. R-222 Flavahan, N.A. and Vanhoutte, P.M. Threshold phenomena and interactions between receptors. J.

Cardiovasc. Pharmacol. 11: S67-S72. 1988. R-223 Marcelon, G. and Vanhoutte, P.M. Venotonic effect of Ruscus under variable temperature

conditions in vitro. Phlebology 3: 51-54, 1988. R-224 Vanhoutte, P.M. Endothelium and Control of Vascular Smooth Muscle. In: Cerebral Vasospasm,

ed. R.H. Wilkins, Raven Press, New York, pp. 119-128, 1988. R-225 Kim, P., Sundt, T.M. and Vanhoutte, P.M. Loss of Endothelium-dependent Relaxation and

Maintenance of Endothelium-dependent Contractions in Chronic Vasospasm Following Subarachnoid Hemorrhage. In: Cerebral Vasospasm, ed. R.H. Wilkins, Raven Press, New York, pp. 145-149, 1988.

R-226 Vanhoutte, P.M. and Lüscher, T.F. Role of the Endothelium in the Pathophysiology of

Hypertension. JAMA (South East Asian Ed.) 4: 34-42, 1988. R-227 Vanhoutte, P.M. The Endothelium and Control of Coronary Arterial Tone. Hospital Practice, pp.

77-94, 1988. R-228 Lüscher, T.F. and Vanhoutte, P.M. Endothelium-dependent responses in human blood vessels.

Trends in Pharmacol. Sci. 9: 181-184, 1988. R-229 Vanhoutte, P.M. and Katusic, Z.S. Endothelium-derived Contracting Factor: Endothelium and/or

Superoxide Anion? Trends in Pharmacol. Sci. 9: 229-230, 1988. R-230 Vanhoutte, P.M. Ca2+-Antagonists: What are they and what do they do? In: Antagonists in

Anaesthesia and Intensive Care, eds. Lawin, Van Aken, Mollmann; Georg Thieme Verlag Stuttgart, New York, pp. 112-129, 1988.

R-231 Van Nueten, J.M., Janssens, W.J. and Vanhoutte, P.M. Calcium Antagonism and Vascular

Smooth Muscle. Ann. N.Y. Acad. Sci. 552: 234-247, 1988. R-232 Houston, D.S., and Vanhoutte, P.M. Pathophysiologic significance of 5-hydroxytryptamine in the

periphery. In: The Peripheral Actions of 5-Hydroxytryptamine, ed. J.R. Fozard, Oxford University Press, New York, pp. 377-406, 1989.

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R-233 Vanhoutte, P.M. Editorial: Epithelium-derived relaxing factor: myth or reality? Thorax 43: 665-668, 1988.

R-234 Lüscher, T.F., Buhler, F.R. and Vanhoutte, P.M. Serotonin and the Cardiovascular System. In:

Neurocardiology, eds. Kulbertus H.E., Franck G., NY, Futura Publishing Co., Inc., Mount Kisco pp. 257-274, 1988.

R-236 Vanhoutte, P.M. The endothelium - modulator of vascular smooth-muscle tone. New England J.

Med. 319: 512-513, 1988. R-237 Kim, P., Katusic, Z.S. and Vanhoutte P.M. Endothelium-dependent responses to arginine

vasopressin. In: Vasopressin: Cellular and Interactive Functions, eds. Cowley, A.W., Jr., Liard, J.F. and Ausiello, D.A., Raven Press, New York, pp. 455-459, 1988.

R-238 Vanhoutte, P.M. and Miller, V.M. Alpha2-adrenoceptors and endothelium-derived relaxing

factor. Am. J. Med. 87: 1S-5S, 1989. R-239 Vanhoutte, P.M. Endothelium, Platelets and Vasospasm. In: Blood Cells and Arteries in

Hypertension and Atherosclerosis, eds. P. Meyer and P. Marche, Raven Press, New York, pp. 1-14, 1989.

R-240 Vanhoutte, P.M. Epithelium-derived relaxing factor(s) and bronchial reactivity. Am. Rev. Respir.

Dis. 138: S24-S30, 1988. R-241 Miller, V.M. and Vanhoutte, P.M. Role of the endothelium in modulating vascular adrenergic

receptor actions. In: Molecular and Cellular Mechanisms of Septic Shock, eds. B. Roth, T. Nielsen and A. McKee, vol. 286, pp. 33-39, 1989.

R-242 Vanhoutte, P.M. Vascular endothelium and Ca2+- antagonists. J. Cardiovasc. Pharmacol. 12:

S21-S28, 1988. R-243 Vanhoutte, P.M. Endothelium-derived relaxing and contracting factors. Heart Failure 5: 5-12,

1989. R-244 Vanhoutte, P.M. and Boulanger, C.M. Endothelium, plaquettes et spasme vasculaire. Artères et

Veines 7: 441-448, 1988. R-245 Vanhoutte, P.M. Aging and Vascular Responsiveness. J. Cardiovasc. Pharmacol. 12: Sll-S18,

1988. R-246 Vanhoutte, P.M. State of the Art Lecture: Endothelium and control of vascular function.

Hypertension 13: 658-667, 1989. R-247 Furchgott, R.F. and Vanhoutte, P.M. Endothelium-derived relaxing and contracting factors.

FASEB J. 3: 2007-2017, 1989. R-248 Lüscher, T.F., Diedrich, D., Buhler, F.R. and Vanhoutte, P.M. Interactions between platelets and

the vessel wall: role of endothelium-derived vasoactive substances. In: Hypertension, Pathology,

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Diagnosis and Management, eds. J.H. Laragh and B.M. Brenner, Raven Press, New York, Chapter 41:637-648, 1990.

R-249 Vanhoutte, P.M. and Shimokawa, H. Endothelium-derived relaxing factor(s) and coronary

vasospasm. Circulation 80: 1-9, 1989. R-250 Katusic, Z.S. and Vanhoutte, P.M. Endothelium-dependent contractions in cerebral arteries. In:

Biosignalling in Cardiac and Vascular Systems, eds. M. Fujiwara, S. Narumiya and S. Miwa, Pergamon Press, 1989.

R-251 Vanhoutte, P.M. The endothelium and the role of 5-hydroxytryptamine in vascular disease. In:

Cardiovascular Pharmacology of 5-hydroxytryptamine: Prospective therapeutic applications, eds. P.R. Saxena, D.I. Wallis, W. Wouters and P. Bevan, Kluwer Scientific Publications, Dordrecht, The Netherlands, 1988.

R-252 Vanhoutte, P.M., Auch-Schwelk, W., Biondi, M.L., Lorenz, R.R., Schini, V.B. and Vidal, M.J.

Why are converting enzyme inhibitors vasodilators? Br. J. Clin. Pharmacol. 28: 95S-104S, 1989. R-253 Vanhoutte, P.M. Endothelium-derived vasoactive factors. Hypertens. Annual, pp. 3-20, 1990. R-254 Vanhoutte, P.M. Facteurs relaxants et contractants dérives de l'endothélium. Actual. Neph. pp. 7-

19, 1989. R-255 Vanhoutte, P.M. Endothelium-derived relaxing and contracting factors. Advances in Nephrology,

19: 3-16, 1990. R-256 Vanhoutte, P.M. Epithelium-derived relaxing factor(s) and bronchial reactivity. J. Allergy Clin.

Immunol. 83: 855-861, 1989. R-257 Vanhoutte, P.M. Endothelium-dependent responses in hypertension. Drugs of Today, 25, 1989. R-258 Shimokawa, H., Flavahan, N.A. and Vanhoutte, P.M. Endothelium-dependent relaxations to

serotonin: signal transduction and effects of diets. International Symposium on "Serotonin. In: Cell Biology to Pharmacology and Therapeutics, eds. Paoletti et al, Florence Italy, pp. 97-104, 1989.

R-259 Vanhoutte, P.M. Vascular effects of serotonin. Progress in Pharmacol. 7: 17-25, 1990. R-260 Vanhoutte, P.M. and Derks, P.M.A. Cardiovasculaire effecten van serotonine en hypertensie. J.

for Drug Therapy and Research 14: 111-114, 1989. R-261 Vanhoutte, P.M. Serotonergic antagonists and vascular disease: Vascular Effects of Platelet-

Released Serotonin. Cardiovasc. Drugs and Therapy, 4: 7-12, 1990. R-262 Shepherd, J.T., Joyner, P.M. and Vanhoutte, P.M. The Sensory Systems Involved in

Cardiovascular Regulation in Cardiology: Fundamentals and Practice, 7: 164-182, 1990. R-263 Vanhoutte, P.M. Claudicatio intermittens: Fysiopathologie en farmacologie. Atherosclerose 55-

72, 1989.

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R-264 Vanhoutte, P.M., Mombouli, J.V., and Shimokawa, H. Facteurs relaxants d'origine endothéliale et spasme coronarien. Arch Mal Coeur, 83: 11-21, 1990.

R-265 Vanhoutte, P.M. La vasodilatation endothelium-dépendante. JAMA (French Ed.) 1: 8-11, 1990. R-266 Morrison, K.J., Gao, Y., and Vanhoutte, P.M. Epithelial modulation of airway smooth muscle.

Am. J. Physiol. 258: L254-L262, 1990. R-267 Vanhoutte, P.M. Endothelium-dependent effects of carteolol. In: New Aspects of Carteolol. Third

Cardiovascular Pharmacotherapy International Symposium, eds. , pp. 8-33, 1989. R-268 Vanhoutte, P.M. Molsidomine is a donor of EDRF. J. Cardiovasc. Pharmacol. 14: S-139-S140,

1989. R-269 Vanhoutte, P.M. Serotonin, Hypertension and Vascular Disease. Netherlands J. Med. 38: 35-42,

1991. R-270 Vanhoutte P.M., Shimokawa H., Boulanger C.M. Fish Oil and the Platelet-Blood Vessel Wall

Interaction. World Rev Nutr Diet, Basel, Karger, 66: 233-244, 1991. R-271 Error R-272 Vanhoutte, P.M. L'endothélium: un régulateur du tonus du muscle lisse vasculaire. Angiologie

104: 1121-1124, 1989. R-273 Miller, V.M. and Vanhoutte, P. M. Endothelium-dependent responses and their potential

relevance to the distribution of blood flow during hemorrhagic shock. Resuscitation, 18: 165-171, 1989.

R-274 Shimokawa, H., Flavahan, N.A. Lorenz, R.R., Vanhoutte. Synergistic interaction between

prostacyclin and endothelium-derived relaxing factor in porcine coronary arteries. In: Endothelium-Derived Relaxing Factors, eds. G.M. Rubanyi and P.M. Vanhoutte, Basel, Karger, pp. 303-308, 1990.

R-275 Flavahan, N.A., and Vanhoutte, P.M. Regulation of endothelium-dependent relaxation by protein

kinase C: possible inhibition of a pertussis toxin-sensitive G protein. In: Endothelium-Derived Relaxing Factors, eds. G.M. Rubanyi and P.M. Vanhoutte, Basel, Karger, pp. 136-142, 1990.

R-276 Katusic, Z.M., and Vanhoutte, P.M. Endothelium-Dependent Contractions to NG-Monomethyl-L-

Arginine in Canine Basilar Artery. In: Endothelium-Derived Relaxing Factors. eds. G.M. Rubanyi and P.M. Vanhoutte, Basel, Karger, pp. 95-98, 1989.

R-277 Auch-Schwelk, W., Katusic, Z., and Vanhoutte, P.M. Endothelium dependent contractions in the

SHR aorta are inhibited by thromboxane A2 receptor antagonists. In: Endothelium-Derived Relaxing Factors, eds. G.M. Rubanyi and P.M. Vanhoutte, Basel, Karger, pp.39-43, 1990.

R-278 Vanhoutte, P.M., and Lüscher, T.F. Endothelium-Dependent Vasoconstriction. In: Endothelium-

derived relaxing factors, eds. G.M. Rubanyi and P.M. Vanhoutte, Basel, Karger, pp. 1-7, 1990. R-279 Komori, K., and Vanhoutte, P.M. Endothelium-derived hyperpolarizing factor. Blood Vessels

27:238-245, 1990.

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R-280 Vanhoutte, P.M. Endothelium-dependent Effects of Beta-Adrenergic Blockers. Blood Vessels

27:301-305, 1990. R-281 Kim, P. and Vanhoutte, P.M. Endothelium-dependent relaxations and chronic vasospasm after

subarachnoid hemorrhage. Blood Vessels 27:263-268, 1990. R-282 Miller, V.M. and Vanhoutte, P.M. Contractions to endothelin in canine veins: effects of calcium

antagonists and inhibitors of endothelium-derived relaxing factor(1). In: Endothelium-derived contracting factors, eds. G. Rubanyi and P.M. Vanhoutte, Basel, Karger, pp. 80-87, 1989.

R-283 Flavahan, N.A. and Vanhoutte, P.M. G-Protein and endothelial responses. Blood Vessels 27:218-229, 1990.

R-284 Stuart-Smith, K. and Vanhoutte, P.M. Epithelium-derived relaxing factor. In: Airway smooth

muscle : modulation of receptors and response, eds. bt D.K. Agrawal and R.G. Townley, CRS Press 6: 129-145, 1990.

R-285 Vanhoutte, P.M. Serotonin to kouketsuatsusho. In: Serotonin and Hypertension, 2: 1-4, 1990. R-286 Romero, J.C., Bentley, M.D., Vanhoutte, P.M. Intrarenal mechanisms that regulate sodium

excretion in relationship to changes in blood pressure. Mayo Clin. Proc. 64: 1406-1424, 1989. R-287 Boulanger, C.M., Shimokawa, H., Schini, V.B., and Vanhoutte, P.M. Vascular Endothelium and

n-3 unsaturated fatty acids. In: Endothelium-derived contracting factors, eds. G. Rubanyi and P.M. Vanhoutte, Basel, Karger, pp. 169-177, 1989.

R-288 Vanhoutte, P.M. Endothelium-derived vasoactive factors, platelets and coronary disease. In: The

Coronary circulation in physiological and pathophysiological states, eds. M. Nakamura and Vanhoutte, P.M. Springer Verlag, Tokyo, Chapter 6: 89-102, 1991.

R-289 Shepherd, J.T., Katusic, Z.S., Vedernikov, Y. and Vanhoutte, P.M. Mechanisms of coronary

vasospasm: role of endothelium, J. Mol. Cellul. Cardiology, 23: 125-131, 1990. R-290 Error R-291 Busk, M.F. and Vanhoutte, P.M. "Epithelium-dependent responses in airways". In: Asthma: its

pathogenesis and treatment, eds. Kaliner, P. Barnes and Persson, 5: 135-188, 1990. R-292 Vanhoutte, P.M. Rôle modulateur de l'endothélium sur la motricité vasculaire. Pharmacologie

Cardio-Vasculaire et Respiratoire 12: 117-122, 1990. R-293 Zellers, T.M. and Vanhoutte, P.M. Lung biology in health and disease endothelial modulation of

pulmonary vascular smooth muscle. In: The Airway Epithelium, ed. S. Farmer, M. Dekker Inc., New York, pp. 565-596, 1991.

R-294 Stuart-Smith, K. and Vanhoutte, P.M. Interactions between epithelium and smooth muscle in

canine airways. In: The Airway Epithelium, ed. S. Farmer, M. Dekker Inc., New York, pp. 485-503, 1991.

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R-295 Vanhoutte, PM Endothelium-derived vasoactive factors and the blood vessel wall interaction. Medicographia, 12: 6-12, 1990.

R-296 Vanhoutte, PM, Lüscher, TF, Gräser, T. Endothelium-Dependent Contractions. Blood Vessels 28:

74-83, 1991. R-297 Vanhoutte, P.M. Epithelium des voies respiratoires et réactivité bronchique. Les Entretiens du

Carla 8: 79-82, 1990. R-298 Félétou, M. and Vanhoutte, P.M. Endothelium, endothelin and local hemodynamic control. J.

Nephrol. 1: 17-27, 1990. R-299 Vanhoutte, P.M. Endothelium, ß-Blockers and vascular protection. Drug Investigation 3: 201-

203, 1991. R-300 Vanhoutte, P.M. Vascular Effects of Serotonin and Ischemia. J. Cardiovasc. Pharmacol. 16: S-15-

S-19, 1990. R-301 Lüscher, T.F. and Vanhoutte, P.M. Endothelium-derived relaxing and contracting agents. In: The

Pulmonary Circulation and Acute Lung Injury, (Second Edition) ed. Sami I. Said, 4: 79-115, 1991.

R-302 Lüscher,T.F. and Vanhoutte,P.M. Dysfunction of the Release of Endothelium-derived Relaxing

Factor. In: Endothelial Cell Dysfunction, eds N. Simionescu, M. Simionescu, Plenum Publishing Corporation, New York, pp. 65-102, 1992.

R-303 Vanhoutte, P.M. Vasospasm or Vasoconstriction? (Letter to the Editor) Eur. J. Plastic Surg. 14:

203-204, 1991. R-304 Boulanger, C.M., and Vanhoutte, P.M. Rôle de l'endothélium dans la régulation de la

vasomotricité. Arch. Mal. Coeur Vaisseaux 84: 35-44, 1991. R-305 Vanhoutte, P.M., Van Nueten, J.M. and Janssens, W.J. The role of the endothelium in the

cardiovascular response to serotonin. In: Serotonin: From Cell Biology to Pharmacology and Therapeutics, eds R. Paoletti, P.M. Vanhoutte, N. Brunello and F.M. Maggi, Kluwer Academic Publishers, Dordrecht, Netherlands, 81-96, 1990.

R-306 Vanhoutte, P.M. and Eber, B. Endothelium-derived relaxing and contracting factors

(Relaxierende und kontrahierende endothelfaktoren). Wiener Klin. Wochenschrift, 14:405-411, 1991.

R-307 Vanhoutte, P.M. Venous wall and venous disease. In: Return Circulation and Norepinephrine: An

Update, ed. Vanhoutte P.M. J. Libbey, Paris, pp. 1-14, 1991. R-308 Höffner, U. and Vanhoutte, P.M. Endothelial factors and regulation of vascular tone; In: Return

Circulation and Norepinephrine: An Update, ed. Vanhoutte P.M., J. Libbey, Paris, pp. 15-29, 1991.

R-309 Boulanger, C., Schini, V.B., Shimokawa, H., Lüscher, T.F. and Vanhoutte, P.M. Effect of

chronic exposure to cod liver oil and 3 unsaturated fatty acids on endothelium dependent relaxations. In: Fish Oil and Blood Vessel Wall Interactions, eds. Vanhoutte P.M. and Douste Blasy Ph., J. Libbey, Paris, pp. 89-97, 1991.

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R-310 Morrison, K.J. and Vanhoutte, P.M. Airway epithelial cells in the pathophysiology of asthma. In:

Advances in the Understanding and Treatment of Asthma. Ann. NY Acad. Sci. 629: 82-88, 1991. R-311 Katusic, Z.S. and Vanhoutte, P.M. Superoxide anion and endothelial regulation of arterial tone.

Sem. Perin. 15: 30-33, 1991. R-312 O'Rourke, S. and Vanhoutte, P.M. Vascular Pharmacology. In: Vascular Medicine, Textbook of

Vascular Biology and Diseases, eds. Loscalzo, J., Dzau, V., and Creager, M.A., CITY, Little, Brown and Co., I: 133-155, 1992.

R-313 Van Nueten, J.M., Janssen, P.A.J., Janssens, W.J. and Vanhoutte, P.M. The development of 5-

HT2 receptor antagonists. In: Serotonin: Actions, Receptors, Pathophysiology, eds. E.J. Mylecharane, Angus, J.A., de la Lande, I.S. and Humphrey, P.A., Macmillan Press, pp. 3-11, 1990.

R-314 Kim, P. and Vanhoutte, P.M. Endothelium-dependent relaxations and contractions. In: Cerebral

Vasospasm, Eds. K. Sano, K. Takakura, N.F. Kassell, and T. Sasaki, University of Tokyo Press, Tokyo, pp. 221-226, 1990.

R-315 Miller, V.M. and Vanhoutte, P.M. Endothelium-dependent vascular responsiveness: Evolutionary

aspects. In: Endothelial Regulation of Vascular Tone, eds. G. Rubanyi and U.S. Ryan, Marcel Dekker, Inc., New York, pp. 1-20, 1991.

R-316 Vanhoutte, P.M. Platelet-derived serotonin, the endothelium, and cardiovascular disease. J.

Cardiovasc. Pharmacol. 17: S6-S12, 1991. R-317 Shepherd, J.T. and Vanhoutte, P.M. Endothelium-derived relaxing (EDRF) and contracting

factors (EDCF) in the control of cardiovascular homeostasis: the pioneering observations. In: Cardiovascular Significance of Endothelium-Derived Vasoactive Factors, ed. Gabor M. Rubanyi, Futura Publishing Co., Mount Kisco, NY, pp. 39-64, 1991.

R-318 Lüscher, T.F., Vanhoutte, P.M., Boulanger, C., Dohi, Y. and Bühler, F.R. Endothelial dysfunction

in hypertension. In: Cardiovascular Significance of Endothelium-Derived Vasoactive Factors, ed. Gabor M. Rubanyi, Futura Publishing Co., Mount Kisco, NY, pp. 199-221, 1991.

R-319 Lüscher, T.F. and Vanhoutte, P.M. Endothelium-derived relaxing factor(s). In: Endogenous

Factors of Cardiovascular Regulation and Protection, eds. M. Cantin, R. Paoletti, P. Braquet, Y. Christen, Excerpta Medica, Amsterdam, pp. 84-121, 1990.

R-320 Vanhoutte, P.M. Endothelial cell mediators of vascular reactivity - Overview. Coronary Artery

Disease, 2: 291-292, 1991. R-321 Schini, V.B. and Vanhoutte, P.M. Endothelin-1: A potent vasoactive peptide. Pharmacol. Toxicol.

69: 1-7, 1991. R-322 Vanhoutte, P.M., Gräser, T. and Lüscher, T.F. Endothelium-derived contracting factors. In:

Endothelin, ed. Gabor Rubanyi, Oxford University Press, Oxford, pp. 3-16, 1992.

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R-323 Vanhoutte, P.M. and Shepherd, J.T.: Pharmacology of large coronary arteries. In: Cardiology: Fundamentals and Practice, Volume 2, eds. R.O. Brandenburg, V. Fuster, E.R. Giuliani and D.C. McGoon, Year Book Medical Publishers, Inc., Chicago, pp. 1159-1171, 1990.

R-324 Error R-325 Peters, Th., Wilffert, B., Vanhoutte, P.M. and van Zwieten, P.A. Calcium channels in the brain as

targets for the calcium-channel modulators used in the treatment of neurological disorders. J. Cardiovasc. Pharmacol. 18: S1-S5, 1991.

R-326 Vanhoutte, P.M. Hypercholesterolaemia, atherosclerosis and release of endothelium-derived

relaxing factor by aggregating platelets. Eur. Heart J. 12: 25-32, 1991. R-327 Vanhoutte, P.M. Platelets, endothelium-derived vasoactive factors and coronary disease.

Cardiologia, 37: 89-93, 1992. R-328 Vanhoutte, P.M. Role of calcium and endothelium in hypertension, cardiovascular disease and

subsequent vascular events. J. Cardiovasc. Pharmacol. 19: S6-S10, 1992. R-329 Vanhoutte, P.M. and Schini, V.B. Endothelin and other endothelium-derived vasoactive factors.

In: Peptide Regulation of Cardiovascular Function, eds. H. Imura, H. Matsuo and T. Masaki, Harcourt Brace Jovanovich, Tokyo, pp. 219-234, 1991.

R-330 Vanhoutte, P.M. Endothelium-derived vasoactive factors, platelets and coronary disease, In:

Schering Lectures, Schering Research Foundation, Berlin, pp. 4-22, 1996. R-331 Edoute, Y., Vanhoutte, P.M. and Rubanyi, G.M. Mechanisms of nickel-induced coronary

vasoconstriction in isolated perfused rat hearts. In: Nickel and Human Health, eds E. Niebour and J.O. Nciagu, Advances in Environmental Science and Technology, John Wiley and Sons Inc. New-York, 25: 587-602, 1992.

R-332 Pearson, P.J. and Vanhoutte, P.M. Vasodilator and vasoconstrictor substances produced by

endothelium. Rev. Physiol. Biochem. Pharmacol. 122: 1-67,1993. R-333 Vanhoutte, P.M. and Boulanger, C.M. L'endothélium vasculaire. Publicité/Information/Liaison,

Paris, France, pp. 1-60, 1992. R-334 Vanhoutte P.M., Boulanger C.M., Vidal M. and Mombouli J.V. Endothelium-derived mediators

and the renin-angiotensin system. In: The Renin-Angiotensin System, eds. J.I.S. Robertson and M.G. Nicholls. Gower Medical Publishing, Chapter 29, pp 29.1-29.15, 1993.

R-335 Vanhoutte, P.M. Is endothelin involved in the pathogenesis of hypertension? Hypertension

21:747-751, 1993. R-336 Schini, V.B., Nagao, T., Illiano, S. and Vanhoutte, P.M. Calcium and the production of

endothelium-derived vasoactive factors. In: Calcium Antagonists: Pharmacology and Clinical Research, eds. T. Godfraind, R. Paoletti and P.M. Vanhoutte, Kluwer Academic Publishers, Dordrecht, The Netherlands, in press.

R-337 Vanhoutte, P.M. International union of pharmacology committee on receptor nomenclature and

drug classification. Pharmacol Rev, 44: 349-350, 1992.

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R-338 Nagao, T., and Vanhoutte, P.M. Endothelium-derived hyperpolarizing factor and endothelium-

dependent relaxations. Am. J. Resp. Cell. Mol. Biol. 8: 1-6, 1993. R-339 Vanhoutte, P.M. Atherosclerosis and nitric oxide. In: Nitric Oxide- The Rational Basis for Nitrate

Therapy, eds. J. Vane and A. Henderson, William Harvey Research Conferences, London, UK, pp 31-33.

R-340 Vanhoutte, P.M. Inducible nitric oxide synthase and vascular smooth muscle. Jap. J. Pharmacol.

15: 192-199, 1992. R-341 Miller, V.M. and Vanhoutte, P.M. Effects of female steroid hormones on endothelium-derived

factors and vascular function. In: Steroid Hormones and Uterine Bleeding, eds. Alexander, N.J., D'Areangues, C. AAAS Press (Washington, D.C.) pp. 301-306, 1992.

R-342 O'Rourke, S.T., and Vanhoutte, P.M. Adrenergic and cholinergic regulation of bronchial vascular

tone. Respiratory Disease 146: 11-14, 1992. R-343 O'Rourke, S.T., and Vanhoutte, P.M. Vascular pharmacology. In: Vascular Medicine, eds.

Loscalzo, J., Creager, M., and Dzau, V. Little, Brown and Comany, Boston, pp. 133-155, 1992. R-344 Vanhoutte, P.M. Other endothelium-derived vasoactive factors. Circulation, 87: V9-V17, 1993. R-345 Vanhoutte, P.M., and Shepherd, J.T. Autonomic nerves to the systemic blood vessels. In:

Peripheral Neuropathy, eds. Dyck, P.J., Thomas, P.K., Griffin, J.W., Low, P.A., and Podulso, J.F. W.B. Saunders Company, Philadelphia, pp. 208-227 (Vol. 1), 1992.

R-346 Morrison, K.J., Gao, Y., and Vanhoutte, P.M. -Adrenoceptors and the epithelial layer in airways. Life Sciences, 52: 2123-2130, 1993. R-347 Schini, V.B., and Vanhoutte, P.M. Endothelium-derived vasoactive factors. In: Thrombosis and

Hemorrhage, eds J. Loscalzo, A.I. Schafer Blackwell Scientific Publications, Inc., Cambridge, Massachusetts, USA, pp 349-367, 1994.

R-348 Scott-Burden, T., and Vanhoutte, P.M. The endothelium as a regulator of vascular smooth muscle

proliferation. Circulation 87: V-51-V-55, 1993. R-349 Morrison, K.J., and Vanhoutte, P.M. Mechanisms of drug action. J. Cardiovasc. Pharmacol. and

Ther. 1-14, 1993. R-350 Vanhoutte, P.M., Boulanger, C.M., Illiano, C., Nagao, T., Vidal, M., and Mombouli, J.V.

Endothelium-dependent effects of converting-enzyme inhibitors. J. Cardiovasc. Pharmacol. 22: S10-S16, 1993.

R-351 Vanhoutte, P.M. Endothelium-derived vasoactive factors and cardiovascular disease. The Journal

of Myocardial Ischemia, 5: 1-7, 1993. R-352 Lüscher, T.F., Rubanyi, G.M., Masaki, T., Vane, J.R., and Vanhoutte, P.M. Endothelial control of

vascular tone and growth. Circulation 87: V1-V2, 1993.

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R-353 Vanhoutte, P.M. Endotheliale dysfunktion und Koronäre Herzkrankheit: Interaktion von Endothel und Thrombozyten. Rundschau Med. (Praxis) 82: 1161-1166, 1993.

R-354 Spedding, M., and Vanhoutte, P.M. Nomenclature of calcium channels and channel modulators:

IUPHAR classification. J. Cardiovasc. Pharmacol. 22: 906, 1993. R-355 Schini, V.B. and Vanhoutte, P.M. Le monoxyde d'azote et l'homéostasie du muscle lisse

vasculaire. Arch. Mal. Coeur 865: 83-89, 1993. R-356 Félétou, M., Canet, E., and Vanhoutte, P.M. NO, endothélium et régulation vasculaire.

Réanimation Urgences, 2: 609-624, 1993. R-357 Spedding, M. and Vanhoutte, P.M. Channel nomenclature: IUPHAR Recommendations. Trends

in Pharmacol. Sci. 14: 435-436, 1993. R-358 Schini, V.B. and Vanhoutte, P.M. Role of the L-arginine-nitric pathway in vascular smooth

muscle. Eur. Heart J. 14: 16-21, 1993. R-359 Vanhoutte, P.M., Barnard, E.A., Cosmides G.J., Humphrey P.P.A., Spedding, M., and Godfraind

T. The IUPHAR Committee on receptor nomenclature and drug classification. Pharm. Rev. 46: 111-116, 1994.

R-360 Masaki, T., Vane, J.R., and Vanhoutte, P.M. IUPHAR nomenclature of endothelin receptors.

Pharm. Rev. 46: 137-142, 1994. R-361 Vanhoutte, P.M. and Scott-Burden, T. The Endothelium in health and disease. Texas Heart

Institute Journal 21: 62-67, 1994. R-362 Morrison, K.J. and Vanhoutte, P.M. Epithelial control over smooth muscle reactivity. In: Asthma

and Rhinitis, eds. Busse WW and Holgate ST, pp 1159-1170, Blackwell Scientific Publications, Boston.

R-363 Vanhoutte, P.M. A matter of life and breath, Nature 368: 693-694, 1994. R-364 Félétou, M., Canet, E., and Vanhoutte, P.M. Endothelial NO and vascular regulation.

Endothelium-derived factors and vascular functions, ed. T. Masaki, Elsevier Science B.V., pp. 47-59, 1994.

R-365 Schini, V.B., Busse, R. and Vanhoutte, P.M. Inducible nitric oxide synthase in vascular smooth

muscle, Arzneim.Forsch./Drug Res. 44: 432-435, 1994. R-366 Scott-Burden, T., and Vanhoutte, P.M. Regulation of smooth muscle cell growth by endothelium-

derived factors. Texas Heart Institute Journal 21: 91-97, 1994. R-367 Schini, V.B., Busse, R. and Vanhoutte, P.M. Inflammatory mediators induce the production of

nitric oxide in vascular smooth muscle. Exp. Nephrol. 2: 139-144, 1994. R-368 Humphrey, P., Spedding, M. and Vanhoutte, P.M. Receptor classification and nomenclature : the

revolution and the resolution. Trends in Pharmacol. Sci. 15: 203-204, 1994.

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R-369 Mombouli, J.V. and Vanhoutte, P.M. Kinins and vascular endothelium. Current Science in Nephrology and Hypertension 3: 481-484, 1994.

R-370 Flavahan, N., and Vanhoutte, P.M. Endothelial cell signaling and endothelial dysfunction. Am. J.

Hypertens. 8: 28S-41S, 1995. R-371 Mombouli, J.V. and Vanhoutte, P.M. Endothelium-derived hyper-polarizing factor(s) and the

potentiation of kinins by converting-enzyme inhibitors. Am. J. Hypertens. 8: 19S-27S, 1995. R-372 Boulanger, C.M., and Vanhoutte, P.M. The endothelium: a pivotal role in health and

cardiovascular disease. R-373 Junquero, D.C., and Vanhoutte, P.M. Increased production of nitric oxide in cultured aortic

smooth muscle cells from SHR. Progress in Hypertension. New Advances in SHR Research, eds Saito et al., 3: 45-56, 1995.

R-374 Vanhoutte, P.M., Koenig-Bérard, E.A., Schutz, D. Les récepteurs aux imidazolines : où allons-

nous ? La Lettre du Pharmacologue, 8: 23, 1994. R-375 Vanhoutte, P.M., and Boulanger, C.M. Endothelium-dependent responses in Hypertension.

Hypertens. Res. 18: 87-98, 1995. R-376 Mombouli J.V. and Vanhoutte, P.M. Kinins and vascular endothelium. Annu. Rev. Pharmacol.

Toxicol. 35: 679-705, 1995. R-377 Canet E, Félétou M, Schini V.B., and Vanhoutte P.M. The L-Arginine-nitric oxide pathway in the

vascular wall. In: The immune consequences of trauma, shock, sepsis. Mechanisms and Therapeutic Approaches, ed. E. Faist, Pabst Science Publishers Lengerich, pp 687-705, 1996.

R-378 O'Rourke, S.T., Vanhoutte, P.M. Vascular pharmacology, In: Vascular Medicine. A textbook of

Vascular Biology and Diseases, eds. J. Loscalzo, M. Creager, V. Dzau ; Little Brown and Campus, Boston MA, pp.117-139.

R-379 Scott-Burden, T., Elizondo, E., Ge, T., Boulanger, C.M. and Vanhoutte, P.M. Protein kinase C

and adenylate regulate nitric oxide production by cultured smooth muscle cells, In: Biology of nitric oxide, eds. Moncada S., Feelisch M., Busse R., Higgs E.A., Vol. 3 Physiological and clinical aspects. Portland Press, London, pp 30-34, 1994.

R-380 Nakashima, M., Félétou, M. and Vanhoutte, P.M. Endothelium-dependent hyperpolarization and

potassium channels. In: Pharmacological control of calcium and potassium Homeostasis,Kluwer Academic Publishers and Fondazione Giovanni Lorenzini, eds. T. Godfraind et al., pp 73-83, 1995.

R-381 Vanhoutte, P.M. The male paradox ? The Lancet, 346: 717, 1995. R-383 Vanhoutte, P.M. Endothelium-derived relaxing factors. Europ. J. Med.Chemist. 3: 361s-370s,

1995. R-384 Schini-Kerth, V.B. and Vanhoutte, P.M. Nitric oxide synthases in vascular cells. Experim.

Physiol. 80: 885-905, 1995.

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R-385 Vanhoutte, P.M. Endothélium vasculaire et tonus vasomoteur. Rev. Med. Liège 50: 18-426, 1995. R-386 Vanhoutte, P.M., Spedding, M. IUPHAR Guidelines for classification of new receptor-subtypes.

Internation. J. Clin. Pharmacol. Ther. 33: 478, 1995. R-387 Vanhoutte, P.M. and Boulanger, C.M. La fonction endothéliale dans l'hypertension artérielle. La

Revue du Praticien, 45: 2513-2517,1995. R-388 Laurent, S., Vanhoutte, P.M., Cavero, I., Chabrier, P.E., Dupuis, B., Elghozi, J.L., Hamon, G.,

Janiak, P., Juillet, Y., Kher, A., Koen, R., Madonna, O., Maffrand, J.P., Pruneau, D., Thuillez, C., Mourad, J.J. La paroi artérielle : une nouvelle cible pharmacologique et thérapeutique ? Thérapie 50: 387-398, 1995.

R-389 Vanhoutte, P.M., Boulanger, C.M. and Mombouli, J.V. Endothelium-derived relaxing factors and

converting enzyme inhibition. Am. J. Cardiol. 76: 3E-12E, 1995. R-390 Cohen, R.A., and Vanhoutte, P.M. Endothelium-dependent hyperpolarization : beyond nitric

oxide and cyclic GMP. Circulation 92: 3337-3349, 1995. R-391 Vane, J.R., Botting, R., and Vanhoutte, P.M. Preface: Up-to-date on endothelins, J. Cardiovasc.

Pharmacol. 26: xi-xii, 1995. R-392 Vanhoutte, P.M., Humphrey, P.P.A., and Spedding, M. International union of pharmacology. X.

Recommendations for nomenclature of new receptor subtypes. Pharmacol. Rev. 48: 1-2, 1996. R-393 Vanhoutte, P.M., Félétou, M., Boulanger, C.M., Höffner, U., and Rubanyi, G. Existence of

multiple endothelium-derived relaxing factors. In: Endothelium-derived hyperpolarizing factor, ed. P.M. Vanhoutte, Harwood Academic publishers, pp. 1-10, 1996.

R-394 Félétou, M., and Vanhoutte, P.M. Bioassay of endothelium-derived hyperpolarizing factor in

canine arteries. In: Endothelium-derived hyperpolarizing factor, ed. P.M. Vanhoutte, Harwood Academic publishers, pp. 25-31, 1996.

R-395 Mombouli, J.V., Bissiriou, I., and Vanhoutte, P.M. Bioassay of endothelium-derived

hyperpolarizing factor : is endothelium-derived depolarizing factor a confounding element ? In: Endothelium-derived hyperpolarizing factor, ed. P.M. Vanhoutte, Harwood Academic publishers, pp.51-55, 1996.

R-396 Corriu, C., Félétou, M., Canet, E., and Vanhoutte, P.M. Inhibitors of the P-450 monooxygenase

pathway do not prevent endothelium-dependent hyperpolarizations in the carotid artery of the guinea-pig. ? In: Endothelium-derived hyperpolarizing factor, ed. P.M. Vanhoutte, Harwood Academic publishers, pp. 91-94, 1996.

R-397 Nakashima, M., and Vanhoutte, P.M. Decreased endothelium-dependent hyperpolarization with

aging and hypertension in the rat mesenteric artery. In: Endothelium-derived hyperpolarizing factor, ed. P.M. Vanhoutte, Harwood Academic publishers, pp.227-233, 1996.

87

R-398 Mombouli, J.V., Bissiriou, I., Agboton, V.D., and Vanhoutte, P.M. Endothelium-derived hyperpolarizing factor: a key mediator of the vasodilator action of bradykinin. Immunopharmacology 33: 46-50, 1996.

R-399 Nakashima, M., Mombouli, J.V., Taylor, A.A., and Vanhoutte, P.M. Endothelium-dependent

hyperpolarization in the human coronary artery. In: Endothelium-derived hyperpolarizing factor, ed. Vanhoutte, P.M., Academic publishers: pp. 279-285, 1996.

R-400 Vanhoutte, P.M. and Félétou, M. Conclusion : existence of multiple endothelium-derived

hyperpolarization factor(s) ? In: Endothelium-derived hyperpolarizing factor, ed. P.M. Vanhoutte, Academic publishers: pp.303-305, 1996.

R-401 Shimokawa, H. and Vanhoutte, P.M. Endothelium and vascular injury in hypertension and

atherosclerosis. In: Handbook of Hypertension, Pathophysiology and Hypertension, eds. A. Zanchetti and G. Mancia. Elsevier, Amsterdam, 17: 1007-1068, 1997.

R-402 Vanhoutte, P.M. Endothelium-dependent responses in congestive heart failure. J. Mol. Cell.

Cardiol. 28: 2233-2240, 1996. R-403 Vanhoutte, P.M. Endothelium vasculaire et tonus vasomoteur. Rev. Port. Cardiol. 15: 27-38,

1996. R-404 Félétou, M., Corriu, C., Canet, E., Nakashima, M., and Vanhoutte, P.M. Endothelium-derived

hyperpolarizing factor (EDHF), an opener of K+ channels in vascular smooth muscle. In: Potassium Channels in Normal and Pathological Conditions, eds. J. Vereecke, P.P. van Bogaert, F. Verdonck. pp. 308-313, 1995.

R-405 Vanhoutte, P.M. La Disfuncion endothelial en la Hipertension Arterial., Iberoamerican Journal of

Hypertension,1: 11-17, 1996. R-406 Laurent, S., Vanhoutte, P.M, Cavero, I., Chabrier, P.E., Dupuis, B., Elghozi, J.L., Hamon, G.,

Janiak, P., Juillet, Y. Kher, A., Koen, R., Madonna, O., Maffrand, J.P., Pruneau, D., Thuillez, C. The arterial wall: a new pharmacological and therapeutic target. Fundam. Clin. Pharmacol. 10: 243-257, 1996.

R-407 Vanhoutte, P.M. Endothelium-dependent responses and inhibition of angiotensin-converting

enzyme. Clin. and Exp. Pharmacol. and Phys. 23: S23-S29, 1996. R-408 Schini-Kerth, V., and Vanhoutte, P.M. Le monoxyde d'azote: un effecteur vasculaire

multifonctionnel. In: L'inflammation, eds. John Libbey Eurotext, pp. 295-303, 1998. R-409 Félétou, M., and Vanhoutte, P.M. Endothelium-derived hyperpolarizing factor. Clin. Exp.

Pharmacol. and Physiol., 23: 1082-1090, 1996. R-410 Vanhoutte, P.M., Perrault, L.P. and Vilaine, J.P. Endothelial dysfunction and vascular disease. In:

The endothelium in clinical practice, eds. G. Rubanyi, V.J. Dzau, Marcel Dekker, pp. 265-289, 1997.

R-411 Vanhoutte, P.M. Endothelial dysfunction in Hypertension. J. Hypertens. 14: S83-S93, 1996.

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R-412 Vanhoutte, P.M. and Mombouli, J.V. Vascular endothelium: vaso-active mediators. Progress in Cardiovascular Diseases,39 (3):229-238, 1996.

R-413 Félétou, M. and Vanhoutte, P.M. The alternative : EDHF. J. Mol. Cardiol. Cell. 31: 15-22, 1999. R-414 Mombouli J.V., and Vanhoutte P.M. Endothelial dysfunction : from physiology to therapy. J.

Mol. Cell. Cardiol. 31:61-74, 1999. R-415 Vanhoutte, P.M. Endothelium-dependent responses and inhibition of angiotensin-converting

enzyme (in Russian). Kardiologiya, 36:71-79, 1996. R-416 Mombouli, J.V., Vanhoutte, P.M. Endothelial function after converting-enzyme inhibition.

Medicographia 18:35-40, 1996. R-417 Vanhoutte, P.M. In: Medicinal chemistry. The challenges for the future. eds. H. van de

Waterbeemd, B. Testa, G. Folkers, pp 1-6, 1997. R-418 Vanhoutte, P.M., Perrault, L.P., Vilaine J.P. Endothelial dysfunction and vascular disease.

Antioxidantes y calidad de vida, 4 (14): 8-24, 1997. R-419 Boulanger, C.M., Vanhoutte, P.M. Vasomotricité d'origine endothéliale - rôle des protéines G.

Sang Thrombose Vaisseaux, 9: 22-30, 1997. R-420 Boulanger, C.M., Vanhoutte, P.M. G-proteins and endothelium-dependent relaxations. J. Vascul.

Res. 34: 175-185, 1997. R-421 Vanhoutte, P.M., Corcaud, S., de Montrion, C. Venous Disease: from pathophysiology to quality

of life. Angiology, 48 (7): 559-567, 1997. R-422 Morrison, K.J., and Vanhoutte, P.M. In: Meccanismi d'azione dei farmaci in Farmacologia e

terapia cardiovascolare. eds. Singh, B.N., Dzau, V.J., Vanhoutte, P.M. and Woosley, R.L. Guidotti, pp.1-8, 1996.

R-423 Mombouli, J.V., and Vanhoutte, P.M. Endothelium-derived hyperpolarizing factor(s) updating the

unknown. Trends in Pharmacol. Sci. 18: 252-256, 1997. R-424 Vanhoutte, P.M. Dysfunction endothéliale et athérosclérose. Réalités Cardiologiques -

Repères pratiques, 115: 29-30, 1997 R-425 Vanhoutte, P.M. Endothelial dysfunction and atherosclerosis. European Heart Journal, 18:

E19-E29, 1997. R-426 Vanhoutte, P.M. Dysfonctionnement endothelial et athérosclérose. Archives des maladies du

coeur et des vaisseaux, 90: 9-19, 1997. R-427 Vanhoutte, P.M. Disfunçao endothelial e aterosclerose. Rev. Port. Cardiol. 16: 23-31, 1997. R-428 Félétou, M., and Vanhoutte, P.M. Endothelium-derived hyperpolarizing factor. In: Vascular

Endothelium in Human Physiology and Pathophysiology. eds. : P.J.T. Vallance, D.J. Webb, Harwood Academic Publishers, pp. 75-93, 1999.

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R-429 Vanhoutte, P.M., and Spedding, M. The international union of pharmacology committee on

receptor nomenclature and drug classification. In: The IUPHAR Compendium of receptor characterization and classification, IUPHAR Media, London, pp. 1-5, 1998.

R-430 Vanhoutte, P.M., Humphrey, P.P.A., and Spedding, M. NC-IUPHAR recommendations for

nomenclature of receptors. In: The IUPHAR Compendium of receptor characterization and classification, IHPHAR Media, London, pp. 31-33, 1998.

R-431 Verbeuren T.J., and Vanhoutte P.M. Vasomotricité et environnement thermique -

physiopathologie des acrosyndromes vasculaires.La revue du praticien, 48:1642,1998. R-432 Vanhoutte, P.M. Endothelial dysfunction and inhibition of converting enzyme. European Heart

Journal, 19: J7-J15,1998. R-433 Vanhoutte, P.M., and Félétou M. Endothelium-dependent hyperpolarization. Pharmacology &

Toxicology, 83: 51-56, 1998. R-434 Vanhoutte, P.M. Endothelial dysfunction and vascular disease. Verhandelingen Koninklijke

Academie voor Geneeskunde van België, 251-266, 1998. R-435 Vanhoutte, P.M. An old-timer makes a come-back. Nature, 396: 213-216, 1998. R-436 Vanhoutte, P.M. and Félétou, M. Concluding Remarks: Identified and unidentified endothelium-

derived hyperpolarizng factors. In: Endothelium-dependent hyperpolarizations. ed. Vanhoutte, P.M., Harwood Academic publishers, pp. 399-403, 1999.

R-437 Vanhoutte, P.M. and Boulanger, C.M. Endothelial function and dysfunction. in: Biology of the

Arterial Wall, eds B. Lévy and A. Tedgui, Kluwer Academic Publishers, pp. 49-70, 1999. R-438 Vanhoutte, P.M. Endothelial dysfunction and vascular disease. In : Endothelium, Nitric oxide and

Atherosclerosis. From Basic Mechanisms to Clinical Implications. eds : J.A. Panza and R.O. Cannon III. Futura Publishing Co, Inc, Armonk, NY, pp.79-95, 1999.

R-439 Boulanger, C.M., and Vanhoutte, P.M. The endothelium: a modulator of cardiovascular health

and disease. Dialogues in Cardiovascular Medicine, 3: 187-200, 1998. R-440 Vanhoutte, P.M. How to assess endothelial function in human blood vessels. J. Hypertens., 17:

1047-1058, 1999. R-441 Félétou, M. and Vanhoutte P.M. Is nitric oxide the only answer? Dialogues in Cardiovascular

Medicine, 3: 202-207, 1998. R-442 Félétou, M. and Vanhoutte P.M. Endothelium-derived hyperpolarizing factor. Drug News

Perspect. 12: 217-222, 1999. R-443 Nicolaides, A. et al. The investigation of chronic venous insufficiency. A consensus statement.

Circulation, 102: e126-e163, 2000. R-444 Vanhoutte, P.M. Oestrogènes et l'organe vasculaire. Thérapie, 54: 323-326, 1999.

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R-445 Félétou, M., and Vanhoutte, P.M. Endothelium-dependent hyperpolarization of vascular smooth

muscle cells, Acta Pharmacologica Sinica, 21:1-18, 2000. R-446 Félétou, M., and Vanhoutte, P.M. The third pathway: endothelium-dependent hyperpolarization.

J. Physiol. Pharmacol., 50: 525-534, 1999. R-447 Vanhoutte, P.M. Say NO to ET. J. Autonom. Nervous System, 81: 271-277, 2000. R-448 De Vriese, A.S, Verbeuren T.J, Van de Voorde J., Lameire, N.H, Vanhoutte P.M. Endothelial

dysfunction in diabetes. Br. J. Pharmacol., 130: 963-974, 2000. R-449 Vanhoutte, P.M. Converting enzyme inhibition and bradykinin. Eur. Heart J.,H1-H2, 2000. R-450 Verbeuren, T.J., Bouskela, E., Cohen, R.A., Vanhoutte, P.M. Regulation of adhesion molecules :

a new target for the treatment of chronic venous insufficiency. Microcirculation, 7: S41-S48, 2000.

R-451 Thollon, C., Fournet-Bourguignon, M.P., Lesage, L., Saboureau, D., Cambarrat, C., Reure, H.,

Vanhoute, P.M., and Vilaine, J.P. Endothelium-derived hyperpolarizing factor maintains a normal relaxation to bradykinin despite the reduced production of nitric oxide in porcine coronary arteries after angioplasty. In: Proceedings of the 3rd International Congress on Coronary Artery Disease, eds. Lyon, 2000.

R-452 Vanhoutte, P.M. Endothelium-derived free radicals: for worse and for better. Journal of Clinical

Investigation, 107:23-25, 2001. R-453 Félétou, M., Vanhoutte, P.M. Prostacyclin and EDHF. Internal Medicine, 8: 19-24, 2000. R-454 Vanhoutte, P.M. Endothelial dysfunction and vascular Disease. In: Pharmacology and

Therapeutics in the New Millennium, ed. S.K. Gupta, Narosa Publishing House, New Delhi, India, p. 1-17, 2001.

R-455 Vanhoutte, P.M. Jing Mai Bi Yao Li Xue( Pharmacology of the venous wall, in Chinese). In:

Progress in pharmacology. Eds. Y.M. Wang and D.F. Su, People’s health Press, Beijing, P.R. China. 2001.

R-456 Félétou, M., and Vanhoutte, P.M. Activation of vascular smooth muscle K+ channels by

endothelium-derived factors. In: Potassium Channels in Cardiovascular Biology, eds. S. Archer and N. Rusch, Kluwer Academic/Plenum Publishers, New York, pp. 691-723, 2001.

R-457 Vanhoutte, P.M. Endothelial adrenoceptors. J. Cardiovasc. Pharmacol.38:796-808, 2001. R-458 Weston, A.H., Edwards, G., Thollon, C., Gardener, M.J., Vilaine, J.-P., Vanhoutte, P.M., and

Félétou, M. Epoxyeicosatrienoic acid and endothelium-dependent hyperpolarization in porcine coronary arteries. In: EDHF 2000, ed. P.M. Vanhoutte, Taylor & Francis, London, pp. 207-213, 2001.

R-459 Quignard, J.F., Chataigneau, T., Corriu, C., Félétou, M., Vanhoutte, P.M. Lipoxygenase-derived

metabolites of arachidonic acid are not involved in the endothelium-dependent hyperpolarization

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to acetylcholine in the carotid artery of the guinea-pig. In: EDHF 2000, ed. P.M. Vanhoutte, Taylor & Francis, London, pp. 214-221, 2001.

R-460 Corriu, C., Vanhoutte, P.M., Félétou, M. Prostacyclin and iloprost in the isolated carotid artery of

the guinea-pig. In: EDHF 2000, ed. P.M. Vanhoutte, Taylor & Francis, London, pp. 294-303, 2001.

R-461 Thollon, C., Fournet-Bourguignon, M.-P., Lesage, L., Saboureau, D., Cambarrat, C., Reure, H.,

Vanhoutte, P.M., Vilaine, J.-V. Endothelium-derived hyperpolarizing factor maintains a normal relaxation to bradykinin despite impairment of the nitric oxide pathway in porcine coronary arteries with regenerated endothelium. In: EDHF 2000, ed. P.M. Vanhoutte, Taylor & Francis, pp. 332-340, 2001.

R-462 De Vriese, A.S., Van de Voorde, J., Vanhoutte, P.M., and Lameire, N.H. Folate restores the NO

synthase-and cyclooxygenase-resistant renal vasodilator response to acetylcholine in diabetes. In: EDHF 2000, ed. P.M. Vanhoutte, Taylor & Francis, London,pp.360-369, 2001.

R-463 Félétou, M, Vanhoutte, P.M. EDHF: gap junction or chemical? and many other questions.

In EDHF 2000, ed. P.M. Vanhoutte, Taylor & Francis, London,pp.424-429, 2001. R-464 Vanhoutte, P.M. Ageing and endothelial dysfunction. Eur. Heart J., 4:A8-A17, 2002. R-465 Vanhoutte, P.M. B2-Kinin receptors : a major player in the release of nitric oxide and EDHF.

Dialogues in cardiovascular medicine, 6: 223-233, 2002. R-466 Fredholm, B., Fleming, W.W., Vanhoutte, P.M., and Godfraind, T. The role of pharmacology in

drug discovery. Nature Review, 1: 237-238, 2002. R-467 Vanhoutte, P.M. Pharmacology of the venous wall. In: Progress in Pharmacology, eds D.F. Su,

C.Y. Miao and Y.M. Wang People’s Health Press, Beijing, 1-7, 2002. R-468 Busse, R., Edwards, G., Félétou, M., Fleming, I., and Vanhoutte, P.M. EDHF: Bringing the

concepts together. Trends in Pharmacol. Sci., 23:374-380, 2002. R-469 Félétou, M., and Vanhoutte, P.M. The third pathway: endothelium-dependent hyperpolarization.

Drug Development Research, 58:18-22, 2003. R-470 Vanhoutte, P.M. Endothelial AT2-receptors : chicken or egg ? Br. J. Pharmacol., 136:481-483, 2002. R-472 Boulanger, C.M., Vanhoutte, P.M. Facteurs vasoactifs produits par l’endothélium vasculaire. In:

Biologie et pathologie du coeur et des vaisseaux, ed : Médecine-Sciences Flammarion, pp. 447-454, 2002.

R-473 Vanhoutte, P.M. Dysfonctionnement endothélial et pathologie vasculaire. In: Journées de

Diabétologie Hôtel-Dieu 2002, ed Flammarion Médecine-Sciences, pp. 1-15, 2002. R-474 Vanhoutte, P.M. Vascular nitric oxide. Hypertension Primer, American Heart Association, pp. 44-

46, 2003.

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R-475 Bychkov, R., Burham, M.P., Richards, G.R., Thollon, C., Edwards, G., Weston, A.H., Vanhoutte, P.M., and Félétou, M. Small and intermediate conductance Ca2+-activated K+ channels(SKCa and IKCa) in porcine coronary endothelium: relevance to EDHF. In: “EDHF 2002”, ed. P.M. Vanhoutte, pp. 261-273, 2003.

R-476 Vanhoutte, P.M. Endothelium-dependent contractions: from superoxide anions to TP-receptor

agonists. Dialogues in Cardiovascular Medicine, 7:211-225, 2003. R-477 Félétou, M., Busse, R., Edwards, G., Fleming I., Weston, A.H., and Vanhoutte, P.M. Dialogue

entre cellules endotheliales et cellulers musculaires lisses. Médecine /Sciences 19:1242-1250, 2003.

R-478 Singh B.N. and Vanhoutte P.M. Selective and specific If inhibition in cardiovascular disease. IN:

“Selective and Specific If Inhibition in Cardiovascular Disease”, eds. B.N. Singh and P.M. Vanhoutte, Lippincott Williams and Wilkins, P.1, 2003

R-479 Vanhoutte, P.M. Endothelium-dependent hyperpolarizations: the history. Pharmacol. Res., 49:

503-508, 2004. R-480 Félétou, M., and Vanhoutte, P.M. EDHF 2002: the take home message. In: “EDHF 2002”, ed.

P.M. Vanhoutte, pp. 371-375, 2003. R-481 Félétou, M., and Vanhoutte, P.M. Endothelium-dependent hyperpolarisation: an alternative

pathway for endothelial cells to control vascular tone. The Cardiology Forum, 2: 18-29, 2002. R-482 Vanhoutte, P.M. Endothelial control of vasomotor function: from health to coronary disease.

Circulation J., 67: 572-575, 2003. R-483 Feletou, M., Vanhoutte, P.M., Weston, A.H., and Edwards G. EDHF and Endothelial potassium

channels: IKCa and SKCa. Letter to the Editor. Br. J. Pharmacol., 140: 225, 2003. R-484 Boulanger, C.M. and Vanhoutte, P.M. Regulation endotheliale du tonus vasomoteur. In:

“L’atherosclerose, physiopathologie, diagnostics, therapeutiques”. Eds: Toussaint,JF, Jacob, MP, Lagrost, L, and Chapman, J. Masson, Paris, pp160-168, 2003.

R-485 Feletou, M. and Vanhoutte, P.M. EDHF: A new Therapeutic Target? Pharmacol. Res.,49: 565-

580, 2004. R-486 Vanhoutte, P.M. Endothelial Function and Dysfunction. Heart and Metabolism, 22: 5-10, 2004. R-488 Félétou, M., Taddei, S. and Vanhoutte, P.M. I fattori iperpolarizzanti. In: Monografie di

Cardiologia, L’endotelio; ed: Salvetti A. & Taddei S., Società Italiana di Cardiologia, pp. 21-28, 2004.

R-489 Vanhoutte, P.M., Félétou, M. and Taddei S. Endothelium-dependent contractions in

hypertension. B.J. Pharmacol., 144: 449-458, 2005. R-490 Haddy, FJ., Vanhoutte, PM and Felectou, M. Role of potassium in regulating blood flow and

blood pressure. Am J. Physiol Regul Integr Comp Physiol 290: R546-R552, 2006.

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R-491 O'Rourke, S.T., Vanhoutte, P.M. and Miller, V.M. (2006) Biology of blood vessels. In: Creager

MA, Dzau V, Loscalso J (eds): Vascular Medicine, A Companion to Braunwald's Heart Disease. Elsevier, Philadelphia, PA, pp. 71-100, 2006.

R-492 Félétou, M., Vanhoutte, P.M. EDHF: Where are we now? Arteriosclerosis, Thrombosis, and

Vascular Biology. Arterioscler Thromb Vasc Biol., 26:1215-1225, 2006. R-494 Félétou, M. & Vanhoutte, P.M. Endothelial dysfunction: a multifaceted disorder (The Wiggers

Award Lecture). Am J Physiol. Heart Circ. Physiol 291: H985-H1002, 2006. R-495 Vanhoutte, P.M. Dysfonctionnement endothelial et pathologie vasculaire. Bulleting et Mémories

de l’Académie royale de Médecine de Belgique, 161:529-537, 2006. R-496 Svendsen, O. , Ahnfelt-Ronne, I. and Vanhoutte, P.M. In vivo Pharmacology in Drug Discovery

and Development. Basic & Clinical Pharmacology & Toxicology, 99: 89-90, 2006. R-497 Félétou, M. and Vanhoutte, P.M. Endothelium-dependent hyperpolarizations: past beliefs and

present facts. Ann. Med., 39: 495-516, 2007. R-498 Félétou, M., Vanhoutte, P.M. Pivotal contribution of potassium channels in endothelium-

dependent responses 1) endothelium-dependent contractions. In: Savineau Jean-Pierre ( ed): New Frontiers in Smooth Muscle Biology and Physiology 2007, pp. 195-222, 2007

R-499 Félétou, M., Vanhoutte, P.M. Pivotal contribution of potassium channels in endothelium-

dependent responses 2) Endothelium-dependent relaxations. In: Savineau Jean-Pierre (ed): New Frontiers in Smooth Muscle Biology and Physiology 2007, 223-249, 2007.

R-500 Vanhoutte, P.M. L’endothelium: Un quart de siecle de surprises. Annales Cardiologie

Angiologie, 2008, 57:133-135, 2008. R-501 Zhu, W., Cheng, K.K.Y., Vanhoutte, P.M., Lam, K.S.L., Xu, A. Vascular effects of adiponectin:

molecular mechanisms and potential therapeutic intervention. Clinical Science, 114: 361-374, 2008.

R-502 Feletou, M., Tang, E.H.C., Vanhoutte, P.M. Nitric oxide the gatekeeper of endothelial vasomotor

control. Front Biosci. 13: 4198-4217, 2008. R-503 Vanhoutte, P.M. Arginine and arginase: eNOS double crossed? Circulation Research, 102: 866-

868, 2008. R-504 Vanhoutte, P.M. EDHF: a quarter of a century and still going strong! Basic Clin Pharmacol

Toxicol, 102 (Supp.1): 1-2, 2009. R-505 Vanhoutte, P.M. Endothelial dysfunction: the first step towards coronary disease. Asia Pacific

Cardiology, 2: 64-68, 2009. R-506 Schini-Kerth, V.B., Vanhoutte, P.M. “Nitric oxide” In: Michael Bader (ed): Cardiovascular

Hormone Systems, 395-406, 2008. Wiley-Blackwell. City and State/Country

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R-507 Vanhoutte, P.M., Tang, E.H.C. Endothelium-dependent contractions: when a good guy turns bad! J Physiol., 586.22: 5295-5304, 2008.

R-508 Félétou, M., Verbeuren, T.J., Vanhoutte, P.M. Endothelium-dependent contractions in SHR: a

tale of prostanoid TP and IP receptors , Br J Pharmacol , 156: 563-574, 2009. R-509 Vanhoutte, P.M., Tang, E, Félétou, M., Shimokawa, H. Endothelial dysfunction and vascular

disease. Acta Physiol., 196: 193-222, 2009. R-510 Vanhoutte, P.M. Endothelial dysfunction: the first step toward coronary arteriosclerosis.

Circulation Journal 73: 595-601, 2009. R-511 Tang, E.H.C., Vanhoutte, P.M. Prostanoids and reactive oxygen species: team players in

endothelium-dependent contractions. Pharmacology & Therapeutics, 122: 140-149, 2009. R-512 Shi, Y., Vanhoutte, P.M. Reactive oxygen-derived free radicals are key to the endothelial

dysfunction of diabetes. J of Diabetes. 1: 151-162, 2009 R-513 Vanhoutte, P.M. How we learned to say NO. Arteriosclerosis Thrombosis Vascular Biology

29:1156-1160, 2009. R-514 Vanhoutte, P.M. COX-1 and vascular disease. Clin Pharmacol Ther, 86: 212-215, 2009. R-515 Michel, T., Vanhoutte, P.M. Cellular signalling and NO production. Pfluegers Archiv-Eur J

Physiol., 459: 807-816, 2010. R-516 Vanhoutte, P.M. Editorial: Highlighted Meetings Series: a new venture. J Cardiovasc

Pharmacol, 55: 299, 2010. R-517 Félétou, M., Vanhoutte, P.M., Verbeuren, T.J. The thromboxane/endoperoxide receptor (TP): the

common villain. J Cardiovasc Pharmacol, 55: 317-332, 2010. R-518 Serban, D.N., Nilius, B., Vanhoutte, P.M. The endothelial saga: the past, the present, the future.

Pfluegers Archiv-Eur J Physiol, 459: 787-792, 2010. R-519 Félétou, M., Huang, Y., Vanhoutte, P.M. Vasoconstrictor prostanoids. Pfluegers Archiv-Eur J

Physiol, 459: 941-950, 2010. R-520 Félétou, M., Köhler, R.,Vanhoutte, P.M. Endothelium derived vasoactive factors and

hypertension: possible roles in pathogenesis and as treatment targets.Current Hypertension reports, 12 : 267-275, 2010.

R-521 Félétou, M., Vanhoutte, P.M. EDHF : an update. Clinical Science, 117:139-155, 2009. R-522 Nilius B., Serban D.N., Vanhoutte, P.M. Robert F. Furchgott and his heritage: endothelial

vasomotor control. Euro J Physiol, 459: 785-786, 2010. R-523 Vanhoutte, P.M. My twenty years at IUPHAR. Pharmacology International. 26-29, 2009.

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R-524 Tang, E.H.C., Vanhoutte, P.M. Endothelial dysfunction: a strategic target in the treatment of hypertension? Euro J Physiol., 459: 995-1004, 2010.

R-525 Vanhoutte, P.M. Regeneration of the endothelium in vascular injury. J Cardiovascular Therapy,

24: 299-303, 2010. R-526 Félétou, M., Cohen, R.A., Vanhoutte, P.M., Verbeuren T.J. TP receptors and oxidative stress:

hand in hand from endothelial dysfunction to atherosclerosis. In: Paul M Vanhoutte (Ed.) Advances in Pharmacol 60, pp.85-106, 2010.

R-527 Wong, M.S.K., Vanhoutte, P.M. COX-mediated endothelium-dependent contractions: from the

past to recent discoveries. Acta Pharmacological Sinica, 31: 1095-1102, 2010. R-528 Lee, M.Y.K., Vanhoutte, P.M. Inflamation and endothelial dysfunction with aging. In: S.M.

Dauphinee & A. Karsan (Eds.) Endothelial Dysfunction and Inflammation. Pg. 189-200, 2010. Springer Basel AG.

R-529 Gao, Y., Vanhoutte, P.M. Nebivolol: an endothelium-friendly selective β1-adrenoceptor blocker.

J Cardiovascular Pharmacology, 59:16-21, 2012. R-530 Wang, Y., Liang Y, Vanhoutte, P.M. SIR1 and AMPK in regulating mammalian senescence: A

critical review and a working model. FEBS Letters, in press, 2011. R-531 Vanhoutte, P.M. Endothelium-dependent contractions in hypertension: when prostacyclin

becomes ugly. Hypertension, 57:526-531, 2011. R-532 Feletou, M., Huang, Y., Vanhoutte, P.M. Endothelium-mediated control of vascular tone: COX-1

and COX-2 products. Br J Pharmacology, 164:894-912, 2011. R-533 Xia, Z., Vanhoutte, P.M. Nitric Oxide and protection against cardiac ischemia. Current

Pharmaceutical Design, 17: 1774-1782, 2011. R-534 Feletou, M., Kohler, R., Vanhoutte, P.M. Nitric oxide: Orchestrator of endothelium-dependent

responses. Annals of Medicine, 44:694-716, 2011. . R-535 Vanhoutte, P.M. Obesity and vascular dysfunction: the fat-e of rich and poor. Br J

Pharmacology, 165:541-543, 2012. R-536 Hui, X., Lam, K.S.L., Vanhoutte, P.M., Xu, A. Adiponectin and cardiovascular health: an update.

Br J Pharmacology, 165: 574-590, 2012. R-537 Wang, P., Vanhoutte, P.M., Miao, C. Visfatin and cardio-cerebro-vascular disease. J Cardiovasc

Pharmacol, 59: 1-9, 2012. R-538 Gao, Y., Vanhoutte, P.M. Nebivolol: an endothelium-friendly selective β1-adrenoceptor blocker.

J Cardiovasc Pharmacol, 59: 16-21, 2012.

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R-539 Xu, A., Vanhoutte, P.M. Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease. Am J Physiol Heart Circ Physiol, 302:H1231-H2340, 2012.

R-540 Tang, E.H.C., Libby, P., Vanhoutte, P.M., Xu, A. Anti-inflammation therapy by activation of

prostaglandin EP4 receptor in cardiovascular and other inflammatory diseases. J Cardiovasc Pharmacol 59: 116-123, 2012.

R-541 Hagensen, M.K., Vanhoutte, P.M., Bentzon, J.F. Arterial endothelial cells: still the craftsmen of

regenerated endothelium. Cardiovasc Research, 95: 281-289, 2012. R-542 Wang, Y., Xu, C., Liang, Y., Vanhoutte, P.M. SIRT1 in metabolic syndrome: where to target

matters. Pharmacology & Therapeutics, 136:305-318, 2012. R-543 Vanhoutte, P.M. Serotonin: beyond the brain. ACS Chemical Neuroscience, 4: 26-27, 2013. R-544 Vanhoutte, P.M. Obésité et Fonction Endothéliale. Lecture présentée à la séance thématique du

20/6/2012 de l’Académie Nationale de Pharmacie. Annales Pharmaceutiques Françaises, 71: 42-50, 2012.

R-545 Barton, M., Yanagisawa, M., Vanhoutte, P.M., Masaki, T. Editorial: Endothelin XII. Life

Sciences 91: 449-451, 2012. R-546 Shi, Y., Vanhoutte, P.M. ROS and EDCF: partners in endothelial dysfunction. In: "Systems

biology of free radicals and anti-oxidants", Ed. I.Laher, Springer-Verlag (Germany), in press, 2012.

R-547 Chan, C.K.Y., Vanhoutte, P.M. Hypoxia, vascular smooth muscles and endothelium. Acta

Pharma Sinica, published online, January 2013. R-548 Juni, R.P., Duckers, H.J., Vanhoutte, P.M., Virmani, R., Moens, A.L. Oxidative stress and

pathological changes after coronary artery interventions. J Am Coll Cardiol, in press, 2013 R-549 Vanhoutte, P.M. Letter to the Editor: MMP-7 and cardiovascular disease: not so surprising!

Basic & Clin Pharmacol & Technology, 112:2, 2013. R-550 Vanhoutte, P.M., Gao, Y. Beta blockers, nitric oxide, and cardiovascular disease. Curr Opin

Pharmacol, 14: 1-9, 2012. R-551 Vanhoutte, P.M. Airway epithelium-derived relaxing factor: myth, reality or naivety. Am J

Physiol Cell, in press, 2013. ABSTRACTS PUBLISHED IN SCIENTIFIC JOURNALS: 1. A-2 Brender, D., Vanhoutte, P.M. and Shepherd, J. Potentiation of adrenergic venomotor responses

by cardiac glycosides. Circulation 39-40 (Suppl. III): 50, 1969. 2. A-3 Vanhoutte, P.M. and Shepherd, J.T. Effect of temperature on reactivity of cutaneous veins to

vasoactive agents. Fed. Proc. 28: 519, 1969.

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3. A-4 Vanhoutte, P.M. and Shepherd, J.T. Effect of temperature on reactivity of different veins of the

dog. The Physiologist 12: 380, 1969. 4. A-5 Vanhoutte, P.M. and Shepherd, J.T. Effect of cooling on beta-receptor mechanisms in isolated

saphenous veins of the dog. Arch. Int. Pharmacodyn. Ther. 185: 208, 1970. 5. A-7 Vanhoutte, P. and Shepherd, J.T. Effect of acetylcholine on reactions of isolated cutaneous veins

to sympathetic stimulation. The Physiologist 15: 293, 1972. 6. A-8 Vanhoutte, P.M. and Shepherd, J.T. Depression by acetylcholine of 3 H-norepinephrine release

from isolated cutaneous veins during sympathetic stimulation. Circulation 46: 308, 1972. 7. A-9 Vanhoutte, P.M. and Shepherd, J.T. Cholinergic venodilatation by inhibition of sympathetic

nerve activity. Clin. Res. 20: 720, 1972. 8. A-10 Vanhoutte, P.M. Aerobic and glycolytic determinants of basal tension and reactivity to

drugs in isolated cutaneous, mesenteric and pulmonary veins of the dog. The Physiologist 16: 297, 1973.

9. A-11 Vanhoutte, P.M. and Lorenz, R.R. Effects of changes in external potassium concentrations

on 3H-norepinephrine release from isolated cutaneous veins. Circulation 47-48 (Suppl. IV): 29, 1973.

10. A-12 Vanhoutte, P.M. and Shepherd, J.T. Effect of anoxia on reactions of isolated cutaneous

veins to vasoactive agents. Clin. Res. 21: 455, 1973. 11. A-13 Vanhoutte, P.M. and Lorenz, R.R. Inhibition of norepinephrine uptake by potassium ions in

vascular smooth muscle. Arch. Int. Pharmacodyn. Ther. 208: 111, 1974. 12. A-15 Muldoon, S. and Vanhoutte, P. Venous relaxation by halothane acting on the sympathetic

nerves. Arch. Int. Pharmacodyn. Ther. 213: 330-331, 1975. 13. A-16 Muldoon, S.M. and Vanhoutte, P.M. Evidence for dual action of etidocaine on adrenergic

transmission in isolated venous smooth muscle. The Pharmacologist 17: 2, 1975. 14. A-17 Vanhoutte, P.M., Dalemans, P. and Verbeuren, T.J. Effects of catecholamines on

adrenergic neuroeffector interaction in isolated cutaneous veins. Circulation 52 (Suppl. II): II-6, 1975.

15. A-19 Vanhoutte, P.M., Van Nueten, J.M., Verbeuren, T.J. and Laduron, P. Enzymatic

degradation and disposition of 3H-norepinephrine in dogs' cutaneous veins. Blood Vessels 12: 381, 1975.

16. A-20 Vanhoutte, P.M. and Verbeuren, T.J. Inhibition of norepinephrine release in vascular

smooth muscle by acetylcholine. Due to hyper-polarization of adrenergic nerve endings? Arch. Int. Pharmacodyn. Ther. 213: 332-333, 1975.

17. A-21 Vanhoutte, P.M. and Verbeuren, T.J. Effects of local cooling on adrenergic

neurotransmission in the dog's cutaneous vein. Arch. Int. Pharmacodyn. Ther. 215: 350, 1975.

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18. A-22 Collis, M.G. and Vanhoutte, P.M. Vascular reactivity in the isolated perfused kidney of the

spontaneously hypertensive rat. Arch. Int. Pharmacodyn. Ther. 223: 164, 1976. 19. A-23 Collis, M.G. and Vanhoutte, P.M. Vascular reactivity in isolated perfused kidneys from

renal hypertensive rats. Circulation 53-54 (Suppl. II): II-175, 1976. 20. A-24 Dalemans, P., Janssens, W., Verbeuren, T.J. and Vanhoutte, P.M. Effect of naturally

occurring catecholamines on adrenergic neuro-effector interaction in isolated cutaneous veins. Arch. Int. Pharmacodyn. Ther. 220: 333-334, 1976.

21. A-25 Muldoon, S.M. and Vanhoutte, P.M. Alpha-adrenergic blocking effect of droperidol on

isolated pulmonary arteries and cutaneous veins of the dog. Fed. Proc. 35: 209, 1976. 22. A-26 Van Hee, R. and Vanhoutte, P.M. Cholinergic inhibition of adrenergic neurotransmission in

dogs' gastric arteries. Arch. Int. Pharmacodyn. Ther. 220: 348, 1976. 23. A-27 Vanhoutte, P.M. and Verbeuren, T.J. Effect of pH-changes on adrenergic neuro-effector

interaction in isolated cutaneous veins. Circulation 53-54 (Suppl. II): II-42, 1976. 24. A-28 Verhaeghe, R. and Vanhoutte, P.M. Effects of adenosine nucleotides on response of

isolated cutaneous veins to adrenergic activation. Fed. Proc. 35: 698, 1976. 25. A-29 Collis, M.G. and Vanhoutte, P.M. Increased renal vascular sensitivity to angiotensin II but

not to norepinephrine is associated with renal hypertension in rats. Eur. J. Clin. Invest., Proc. lOth Ann. Meeting, A5, 1977.

26. A-30 Collis, M.G. and Vanhoutte, P.M. Increased responsiveness to renal nerve stimulation in

isolated perfused kidneys from young spontaneously hypertensive rats. Circulation 55-56 (Suppl. III): III-161, 1977.

27. A-31 Driessens, M. and Vanhoutte, P.M. Vascular reactivity in an isolated bone preparation.

Arch. Int. Pharmacodyn. Ther. 230: 330, 1977. 28. A-32 De Mey, J. and Vanhoutte, P.M. Comparison of the reactivity of isolated saphenous veins

of rabbit and dog. Arch. Int. Pharmacodyn. Ther. 227: 155-156, 1977. 29. A-33 Greenberg, S., Curro, F.A., Vanhoutte, P.M. and Verbeuren, T.J. Evidence for the existence

of two subtypes of alpha-adrenoceptors in canine saphenous veins. Fed. Proc. 36: 464, 1977. 30. A-34 Gutheil, K., Curro, F.A., Patil, P.N., Vanhoutte, P.M. and Greenberg, S. The effect of

calcium ion on adrenoceptor blocking activity of phentolamine. The Pharmacologist 19: 130, 1977.

31. A-35 Janssens, W.J. and Vanhoutte, P.M. Effect of temperature on the disposition of

neurotransmitters in the saphenous veins of the dog. Arch. Int. Pharmacodyn. Ther. 226: 346-347, 1977.

32. A-36 Janssens, W.J. and Vanhoutte, P.M. Effect of temperature on drug-receptor interaction in

isolated canine veins. Arch. Int. Pharmacodyn. Ther. 227: 164-165, 1977.

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33. A-37 Janssens, W.J. and Vanhoutte, P.M. Instantaneous changes of alpha-adrenoceptor affinity

caused by moderate cooling in canine cutaneous veins. Circulation 55-56 (Suppl. III): III-202, 1977.

34. A-38 Janssens, W.J. and Vanhoutte, P.M. Sodium-potassium ATPase is not involved in

temperature sensitivity of isolated canine veins. J. Pharmacol. (Paris) 8: 557, 1977. 35. A-39 McGrath, M.A. and Vanhoutte, P.M. Interference with peripheral adrenergic

neurotransmission. Blood Vessels 14: 257-258, 1977. 36. A-41 Vanhoutte, P.M. and Verbeuren, T.J. Moderate acidosis depresses neuronal uptake of

norepinephrine in canine saphenous veins. The Physiologist 20: 97, 1977. 37. A-43 Vanhoutte, P.M., Verbeuren, T.J. and Collis, M.G. Muscarinic inhibition of adrenergic

neurotransmission is not due to direct interference with Ca++ entry in the adrenergic nerve endings. J. Pharmacol. (Paris) 8: 556-557, 1977.

38. A-44 Vermeire, P.A. and Vanhoutte, P.M. Inhibition by catecholamines of cholinergic

neurotransmission in canine bronchi in vitro. Arch. Int. Pharmacodyn. Ther. 227: 175-176, 1977. 39. A-46 Vermeire, P.A. and Vanhoutte, P.M. Inhibition of cholinergic neuro-transmission by

catecholamines mediating adrenergic bronchodilatation in the dog. Bull. Eur. Physiopath. Resp. 13: 118P-119P, 1977.

40. A-49 De Mey, Ch., Zonnekeyn, L. and Vanhoutte, P.M. Comparison of the tachyphylaxis to 5-

hydroxytryptamine and angiotensin II in the isolated perfused kidney of the spontaneously hypertensive rat. Arch. Int. Pharmacodyn. Ther. 236: 298-299, 1978.

41. A-51 De Mey, J.G. and Vanhoutte, P.M. Oxygen-dependency of the acetylcholine induced

relaxation in vascular smooth muscle. Arch. Int. Pharmacodyn. Ther. 234: 339, 1978. 42. A-52 De Mey, J.G. and Vanhoutte, P.M. Calcium-dependency of the direct relaxant effect of

acetylcholine on canine femoral artery. Arch. Int. Pharmacodyn. Ther. 236: 296, 1978. 43. A-54 De Mey, J.G. and Vanhoutte, P.M. Disposition of adrenergic neurotransmitter in saphenous

veins of dog and rabbit. Br. J. Pharmacol. 63: 341P-342P, 1978. 44. A-55 Driessens, M. and Vanhoutte, P.M. Vascular reacivity of the isolated perfused tibia of the

dog. Fed. Proc. 37: 876, 1978. 45. A-56 Herman, A.G., Verbeuren, T.J., Moncada, S., Vane, J.R. and Vanhoutte, P.M. Effect of

prostacyclin on myogenic activity and adrenergic neuroeffector interaction in isolated canine veins. Arch. Int. Pharmacodyn. Ther. 232: 340-341, 1978.

46. A-57 Janssens, W.J. and Vanhoutte, P.M. Effect of cooling on COMT-activity in canine

saphenous vein homogenates determined by a microradio-enzymatic assay. Arch. Int. Pharmacodyn. Ther. 236: 305-306, 1978.

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47. A-58 Janssens, W.J. and Vanhoutte, P.M. Instantaneous changes of alpha-adrenoceptor affinity caused by moderate cooling in canine cutaneous veins. Acta Cardiologica 33: 30, 1978.

48. A-63 Van Maercke, Y., Van Moer, E., Bauwens, G. and Vanhoutte, P.M. Effect of pentagastrin

on the reactivity of isolated canine blood vessels. Arch. Int. Pharmacodyn. Ther. 232: 347, 1978. 49. A-64 Verbeuren, T.J. and Vanhoutte, P.M. Influence of MAO-inhibitors on deamination of 3H-

norepinephrine in the dog's saphenous vein. Arch. Int. Pharmacodyn. Ther. 232: 348-349, 1978. 50. A-65 Verbeuren, T.J. and Vanhoutte, P.M. Deamination of 3H-norepinephrine in the dog's

saphenous vein. Fed. Proc. 37: 684, 1978. 51. A-66 Verbeuren, T.J. and Vanhoutte, P M. Effect of blockade of neuronal uptake on the evoked

release of 3H-norepinephrine in the saphenous vein of the dog. Arch. Int. Pharmacodyn. Ther. 234: 349-350, 1978.

52. A-67 Vercruysse, P., Hanegreefs, G. and Vanhoutte, P.M. Influence of skeletal muscle relaxants

on the prejunctional effects of acetylcholine in adrenergically innervated blood vessels. Arch. Int. Pharmacodyn. Ther. 232: 350, 1978.

53. A-69 Vermeire, P. and Vanhoutte, P.M. Do different subtypes of beta-adrenergic receptors

mediate the pre- and postjunctional effects of catecholamines in isolated canine bronchi? Ann. Rev. Resp. Dis. 117: 408, 1978.

54. A-70 Webb, R.C., Vanhoutte, P.M. and Bohr, D.F. Effect of potassium on the mechanical

activity of rat tail artery. Arch. Int. Pharmacodyn. Ther. 236: 329-330, 1978. 55. A-71 Anderson, M.J., Cambridge, D., Davey, M.J., Massingham, R., Vanhoutte, P.M. and

Verbeuren, T.J. The effect of a high dose of prazosin and transmural stimulation on the disposition of transmitter noradrenaline in the rabbit pulmonary artery and the dog saphenous vein. Br. J. Pharmacol. 66: 151P-152P, 1979.

56. A-73 De Mey, Ch. and Vanhoutte, P.M. Tachyphylaxis to 5-hydroxytryptamine and angiotensin

II in the isolated perfused kidney of the spontaneously hypertensive rat. Eur. J. Clin. Invest., Proceedings, 13th Annual Meeting, 1979.

57. A-74 De Mey, Ch., Zonnekeyn, L. and Vanhoutte, P.M. Aging and responsiveness to 5-

hydroxytryptamine in the perfused kidney of spontaneously hypertensive rats. Acta Cardiologica 34: 35, 1979.

58. A-75 De Mey, Ch., Zonnekeyn, L. and Vanhoutte, P.M. The influence of age on the vascular

reactivity to 5-hydroxytryptamine in the isolated perfused kidney of the spontaneously hypertensive and normotensive rats. Blood Vessels 16: 212, 1979.

59. A-76 De Mey, J., Burnstock, G. and Vanhoutte, P.M. Differential effects of adenosine and

adenosine-triphosphate in canine saphenous veins. Blood Vessels 16: 212, 1979. 60. A-77 De Mey, J.G. and Vanhoutte, P.M. Is the direct relaxing effect of acetylcholine on vascular

smooth muscle due to activation of Na+/K+ ATP.ase? Br. J. Pharmacol. 66: 150P, 1979.

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61. A-78 De Mey, J.G. and Vanhoutte, P.M. Relaxation of the isolated canine femoral artery caused by acetylcholine and by potassium ions. The Physiologist 22: 28, 1979.

62. A-79 Janssens, W.J. and Vanhoutte, P.M. Effect of cooling on efflux of 3H-norepinephrine in

canine cutaneous veins. Br. J. Pharmacol. 66: 148P, 1979. 63. A-80 Rusch, N.J., Shepherd, J.T. and Vanhoutte, P.M. Effect of profound cooling on adrenergic

neuroeffector interaction in the blood vessel wall. Br. J. Pharmacol. 66: 149P, 1979. 64. A-81 Rusch, N.J., Shepherd, J.T. and Vanhoutte, P.M. Effect of stepwise rewarming on the

response of canine cutaneous veins to sympathetic stimulation. Fed. Proc. 38: 1228, 1979. 65. A-82 Rusch, N.J., Webb, R.C., Shepherd, J.T. and Vanhoutte, P.M. Blood flow responses of the

human calf and forearm. The Physiologist 22: 110, 1979. 66. A-84 Vanhoutte, P.M., Bossuyt, P., Coen, E., De Ridder, W. and Verbeuren, T.J. Acetylcholine

inhibits the release of endogenous norepinephrine in the dog's saphenous veins. Blood Vessels 16: 222, 1979.

67. A-86 Vanhoutte, P.M. and Verbeuren, T.J. Role of neuronal uptake in the disposition of released

3H-norepinephrine in the dog's saphenous vein. Br. J. Pharmacol. 66: 116, 1979. 68. A-87 Vanhoutte, P.M. and Webb, R.C. Inactivation of released norepinephrine in rat tail artery

by neuronal uptake. Br. J. Pharmacol. 66: 116, 1979. 69. A-88 Verbeuren, T.J., Coen, E.P., De Ridder, W.J. and Vanhoutte, P.M. Measurement of

endogenous norepinephrine released by nerve stimulation in the dog's saphenous vein by a radioenzymatic method. Blood Vessels 16: 222, 1979.

70. A-89 Vercruysse, P., Bossuyt, P., Jordaens, F., Verbeuren, T.J. and Vanhoutte, P.M. Gallamine

inhibits the depression of the nerve stimulation induced norepinephrine release caused by acetylcholine in dog's saphenous veins. Blood Vessels 16: 222, 1979.

71. A-92 Webb, R.C. and Vanhoutte, P.M. Effect of potassium on nerve endings and effector cells in

isolated vascular smooth muscle. The Physiologist 22: 130, 1979. 72. A-93 Webb, R.C., Verbeuren, T.J., Coen, E.P. and Vanhoutte, P.M. Decreased sensitivity to

cocaine in isolated arteries of spontaneously hypertensive rats. Fed. Proc. 38: 1234, 1979. 73. A-94 Burrows, M.E. and Vanhoutte, P.M. Acetylcholine relaxation in resting and contracted rat

mesenteric arterioles. Fed. Proc. 39: 272, 1980. 74. A-95 De Mey, J., De Ridder, W. and Vanhoutte, P.M. Different potencies of alpha-adrenergic

antagonists in canine arteries and veins. Blood Vessels 17: 148, 1980. 75. A-97 De Mey, J.G. and Vanhoutte, P.M. Differences in pharmacological properties of

postjunctional alpha-adrenergic receptors among arteries and veins. Arch. Int. Pharmacodyn. Ther. 244: 328-329, 1980.

102

76. A-98 De Mey, J. and Vanhoutte, P.M. Dependency on monovalent alkali ions of the direct relaxant effects of acetylcholine in the canine femoral artery. Blood Vessels 17: 148, 1980.

77. A-99 De Mey, J. and Vanhoutte, P.M. Endothelium and relaxation of isolated canine arteries.

The Pharmacologist 22: 282, 1980. 78. A-100 Driessens, M.F. and Vanhoutte, P.M. Effect of calcitonin, parathormone and

hydrocortisone on vascular reactivity of the isolated tibia of the dog. Blood Vessels 17: 149, 1980.

79. A-102 Janczewska, H., De Mey, J. and Vanhoutte, P.M. Mediators of functional hyperemia and

reactivity of isolated arteries and veins to acetylcholine. Blood Vessels 17: 152, 1980. 80. A-103 Janssens, W. J. and Vanhoutte, P.M. Effect of moderate cooling on the overflow of

endogenous and tritiated norepinephrine in canine saphenous veins. Arch. Int. Pharmacodyn. Ther. 244: 336-337, 1980.

81. A-105 Rusch, N.J., Shepherd, J.T. and Vanhoutte, P.M. Alternation of contraction and relaxation

during profound cooling in canine cutaneous veins. J. Physiol. 295: 74P-75P, 1980. 82. A-109 Vanhoutte, P.M., De Ridder, W. and De Mey, J. Characteristics of postjunctional alpha-

adrenoceptors in canine arteries and veins. Fed. Proc. 39: 1070, 1980. 83. A-110 Vanhoutte, P.M., De Ridder, W., Verbeuren, T.J. and De Mey, J. Moderate cooling and

responses to various alpha-adrenergic agonists in canine cutaneous veins. The Physiologist 23: 102, 1980.

84. A-112 Van Nueten, J.M. and Vanhoutte, P.M. Contraction of isolated coronary arteries caused by

norepinephrine, 5-hydroxytryptamine, anoxia and ergonovine. Blood Vessels 17: 167, 1980. 85. A-114 Verbeuren, T.J., Coen, E.P., Collis, M.G., Janssens, W.J. and Vanhoutte, P.M. Adenosine

but not acetylcholine inhibits norepinephrine release evoked by the Ca2+ ionophore A23187. Blood Vessels 17: 167-168, 1980.

86. A-116 Webb, R.C., Lockette, W.E., Bohr, D.F. and Vanhoutte, P.M. Monovalent ion specificity of

the electrogenic sodium pump in vascular smooth muscle. Blood Vessels 17: 168, 1980. 87. A-117 Webb, R.C., Rusch, N.J. and Vanhoutte, P.M. Comparison of forearm reactive hyperemia in

male and female subjects. Fed. Proc. 39: 383, 1980. 88. A-118 Aarhus, L.L., Donald, D.E., Shepherd, J.T., Tyce, G.M. and Vanhoutte, P.M. Obligatory

role of adrenergic nerve endings in the contractile response of splenic artery, capsule and vein to ouabain. Fed. Proc. 40: 2835, 1981.

89. A-119 De Mey, J. and Vanhoutte, P.M. Removal of endothelium and arterial reactivity to

acetylcholine and adenine nucleotides. Br. J. Pharmacol. 72: 510P, 1981. 90. A-120 De Mey, J.G. and Vanhoutte, P.M. Differential effects of Na+ loading and activation of

Na+ pumping in canine arterial and venous smooth muscle. Arch. Int. Pharmacodyn. Ther. 250: 312-313, 1981.

103

91. A-121 De Mey, J.G. and Vanhoutte, P.M. Role of the intima in the relaxation of the canine

femoral artery caused by thrombin. Arch. Int. Pharmacodyn. Ther. 250: 314-315, 1981. 92. A-122 Vanhoutte, P.M., De Ridder, W.J. and De Mey, J. Differences in pre- and postjunctional

cholinergic responsiveness between canine arteries and veins. Fed. Proc. 240: 659, 1981. 93. A-124 Vanhoutte, P.M., Zonnekeyn, L. and Verbeuren, T.J. Transmission adrenergique dans le

rein du rat hypertendu adulte. J. Physiol. (Paris) 8: 4A, 1981. 94. A-126 Van Nueten, J.M. and Vanhoutte, P.M. Vascular effects of the serotonergic antagonist R 41

468. Fed. Proc. 40: 267, 1981. 95. A-127 Van Nueten, J.M., Vanhoutte, P.M. and Janssen, P.A.J. Comparison of the pharmacological

properties of serotonergic responses in the vasculature with those in bronchial and gastrointestinal smooth muscle. Blood Vessels 18: 230, 1981.

96. A-130 Van Nueten, J.M., Xhonneux, R., Vanhoutte, P.M. and Janssen, P.A.J. Vascular activity of

ketanserin (R41468), a selective 5-HT2 receptor antagonist. Arch. Int. Pharmacodyn. Ther. 250: 328-329, 1981.

97. A-131 Will, L. and Vanhoutte, P.M. Effets de l'hydrocortisone et du 17-e-oestradiol sur la

reactivite des vaisseaux isoles du chien. J. Physiol. (Paris) 8: 4A, 1981. 98. A-133 De Mey, J.G. and Vanhoutte, P.M. Contribution of the endothelium to the response to

anoxia in the canine femoral artery. Arch. Int. Pharmacodyn. Ther. 253: 325-326, 1981. 99. A-134 Boels, P.J. and Vanhoutte, P.M. Formation of 3H-dopamine and 3H-noradrenaline from 3H

tyrosine in the canine saphenous vein. Arch. Int. Pharmacodyn. Ther. 253: 315-316, 1981. 100. A-135 De Mey, J.G. and Vanhoutte, P.M. Endothelium and arterial effects of adenine nucleosides.

The Physiologist 24: 72, 1981. 101. A-136 Verbeuren, T.J., Lorenz, R.R., Shepherd, J.T. and Vanhoutte, P.M. Comparison of the

functional importance of prejunctional beta-adrenoceptors in human and canine blood vessels. Fed. Proc. 41: 1630, 1982.

102. A-141 Boels, P.J., Coen, E. and Vanhoutte, P.M. L.Tyrosine and adrenergic neuroeffector

interaction in the canine saphenous vein. Arch. Int. Pharmacodyn. Ther. 256: 155-156, 1982. 103. A-142 Boels, P.J., De Potter, W.P. and Vanhoutte, P.M. Release of newly synthesized 3H-

noradrenaline from adrenergic nerve endings in the canine saphenous vein. Arch. Int. Pharmacodyn. Ther. 256: 157-158, 1982.

104. A-143 Cohen, R.A., Vanhoutte, P.M. and Shepherd, J.T. Neurogenic beta and alpha adrenergic

activation in large and small canine coronary arteries. Fed. Proc. 41: 1598, 1982. 105. A-144 Rimele, T.J. and Vanhoutte, P.M. Indomethacin augments the veno-constrictor effect of

acetylcholine independently of the endothelium in the canine saphenous vein. Fed. Proc. 41: 1233, 1982.

104

106. A-152 Cohen, R.A., Shepherd, J.T. and Vanhoutte, P.M. Aggregating platelets and 5-hydroxytryptamine inhibit canine coronary artery smooth muscle tone by an endothelium-mediated process. The Physiologist 25: 240, 1982.

107. A-153 Rimele, T.J. and Vanhoutte, P.M. Calcium and alpha-adrenoceptor activation in isolated

canine blood vessels. The Physiologist 25: 239, 1982. 108. A-154 Rusch, N.J., Shepherd, J.T. and Vanhoutte, P.M. Increase in alpha-adrenoceptor affinity in

dog saphenous vein caused by profound cooling. The Physiologist 25: 239, 1982. 109. A-155 Cohen, R.A., Shepherd, J.T. and Vanhoutte, P.M. Augmentation by Prejunctional alpha-

adrenergic blockade of sympathetic beta-adrenergic relaxation in canine coronary artery. Circulation 66: II-153, 1982.

110. A-156 Verbeuren, T.J., Coen, E.P. and Vanhoutte, P M. Influence of neuronal uptake inhibitors on

tissue accumulation of 3H-norepinephrine and its metabolites in isolated canine saphenous veins. Arch. Int. Pharmacodyn. Ther. 260: 314-315, 1982.

111. A-157 McGoon, M.D. and Vanhoutte, P.M. Ketanserin inhibits contractions of isolated canine

pulmonary arteries caused by platelets and 5-hydroxytryptamine. Fed. Proc. 42: 594, 1983. 112. A-158 Vanhoutte, P.M., Lorenz, R.R., Rimele, T.J. and Verbeuren, T.J. Metabolism of buflomedil

by the adrenergic nerve endings increases its efficacy. Fed. Proc. 42: 636, 1983. 113. A-159 Lorenz, R.R. and Vanhoutte, P.M. Effects of bucindolol on adrenergic nerve endings in the

canine saphenous vein. Fed. Proc. 42: 648, 1983. 114. A-160 Aarhus, L.L., Rimele, T.J., Rooke, T.W. and Vanhoutte, P.M. Effects of bucindolol on

isolated canine vascular smooth muscle. Fed. Proc. 42: 749, 1983. 115. A-161 Lindblad, L.E., Shepherd, J.T. and Vanhoutte, P.M. Effect of moderate cooling on

responses of canine saphenous veins to alpha1 - and alpha2-adrenergic agonists. Fed. Proc. 42: 749, 1983.

116. A-162 Rusch, N.J., Vanhoutte, P.M. and Shepherd, J.T. Interruption of neurotransmission by

profound cooling in canine cutaneous arteries. Fed. Proc. 42: 749, 1983. 117. A-163 Cohen. R.A., Shepherd, J.T. and Vanhoutte, P.M. Involvement of the endothelium in

responses of vascular smooth muscle to intra-versus extraluminal applications of vasoactive substances. Fed. Proc. 42: 1263, 1983.

118. A-164 Rimele, T.J. and Vanhoutte, P.M. Acute anoxia augments the entry of Ca2+ in quiescent

coronary vascular smooth muscle. Fed. Proc. 42: 1263, 1983. 119. A-165 Rooke, T.W., Rimele, T.J. and Vanhoutte, P.M. Potassium augments prostaglandin

F2alpha_-induced contractions of dog coronary artery in calcium-free solution. Fed. Proc. 42: 1263, 1983.

120. A-166 Vanhoutte, P.M. Control of venous function. Int. Angiology 3 (suppl.): 16, 1983.

105

121. A-167 Marcelon, G. and Vanhoutte, P.M. Proposed mechanism of action for Ruscus extract. Int. Angiology 3 (suppl.): 23, 1983.

122. A-173 Rimele, T.J. and Vanhoutte, P.M. Alpha1-adrenoceptors and calcium in isolated canine

coronary arteries. The Pharmacologist 25: 136, 1983. 123. A-174 Cohen, R.A., Shepherd, J.T. and Vanhoutte, P.M. Inhibitory role of the endothelium in

response of isolated canine coronary arteries to platelets. Blood Vessels 20: 188-189, 1983. 124. A-175 Vanhoutte, P.M., Aarhus, L.L., Lorenz, R.R. and Verbeuren, T.J. Effects of buflomedil on

the responsiveness of canine vascular smooth muscle. Blood Vessels 20: 208, 1983. 125. A-181 McGoon, M.D. and Vanhoutte, P.M. Serotonin is the predominant mediator of platelet-

evoked contraction of canine pulmonary artery. Circulation 68 (suppl. III): III-400, 1983. 126. A-182 Lindblad, L.E. and Vanhoutte, P.M. Augmentation by cold of platelet induced contraction

of peripheral arteries of the dog. Circulation 68 (suppl. III): III-201, 1983. 127. A-183 Vanhoutte, P.M., Aarhus, L.L., Lorenz, R.R. and Verbeuren, T.J. Effects of buflomedil on

the responsiveness of canine vascular smooth muscle. Blood Vessels 20: 208, 1983. 128. A-184 Cohen, R.A., Shepherd, J.T. and Vanhoutte, P.M. Inhibitory role of the endothelium in

response of isolated canine coronary arteries to platelets. Blood Vessels 20: 188-189, 1983. 129. A-186 Daskalopoulos, D.A., Rimele, T.J. and Vanhoutte, P.M. Alpha1-and alpha2-adrenoceptors

and calcium in the isolated canine saphenous vein. Fed. Proc. 43: 352, 1984. 130. A-187 Rimele, T.J. and Vanhoutte, P.M. Characterization of alpha1-and alpha2-adrenoceptors in

the isolated canine saphenous vein. Fed. Proc. 43: 352, 1984. 131. A-188 Lindblad, L.E., Lorenz, R.R., Shepherd, J.T. and Vanhoutte, P.M. Effect of vibration on a

canine cutaneous artery. Fed. Proc. 43: 426, 1984. 132. A-189 Miller, V.M. and Vanhoutte, P.M. Endothelium-dependent responses to arachidonic acid in

canine veins. Fed. Proc. 43: 429, 1984. 133. A-190 Flavahan, N.A. and Vanhoutte, P.M. Epithelial-dependent attenuation of bronchial smooth

muscle tone. Fed. Proc. 43: 429, 1984. 134. A-191 Lorenz, R.R. and Vanhoutte, P.M. Aggregating platelets and adrenergic neurotransmission

in isolated canine blood vessels. Fed. Proc. 43: 430, 1984. 135. A-192 Cooke, J.P., Shanley, T., Shepherd, J.T. and Vanhoutte, P.M. Ouabain reverses beta-

adrenergic predominance in isolated canine coronary arteries. Fed. Proc. 43: 899, 1984. 136. A-193 Cohen, R.A., Shepherd, J.T. and Vanhoutte, P.M. Neurogenic cholinergic prejunctional

inhibition of sympathetic beta-adrenergic relaxation in the canine coronary artery. Fed. Proc. 43: 900, 1984.

137. A-194 Rubanyi, G. and Vanhoutte, P.M. Inhibition of prostaglandin synthesis enhances beta-

adrenoceptor responsiveness in canine coronary arteries. Fed. Proc. 43: 900, 1984.

106

138. A-195 Aarhus, L.L., Rimele, T.J. and Vanhoutte, P.M. Removal of the epithelium causes

bronchial supersensitivity to acetylcholine and 5-hydroxytryptamine. Fed. Proc. 43: 955, 1984. 139. A-196 Houston, D.S., Shepherd, J.T. and Vanhoutte, P.M. Platelets cause endothelium-dependent

relaxations in some but not all isolated canine vessels. Fed. Proc. 43: 1084, 1984. 140. A-197 Katusic, Z., Shepherd, J.T. and Vanhoutte, P.M. Arginine vasopressin induces

endothelium-dependent relaxations of canine basilar and coronary arteries. Fed. Proc. 43: 1084, 1984.

141. A-200 Vanhoutte, P.M. 5-Hydroxytryptamine and hypertension. Blood Vessels 21: 203, 1984. 142. A-201 Rubanyi, G.M. and Vanhoutte, P.M. Catecholamines inactivate endothelial relaxing factor

in canine coronary arteries. The Physiologist 27: 231, 1984. 143. A-202 Flavahan, N.A. and Vanhoutte, P.M. The receptor-reserve determines the modulation by

cooling of alpha-adrenergic responses in canine cutaneous veins. The Physiologist 27: 282, 1984. 144. A-203 Miller, V.M. and Vanhoutte, P.M. Muscular and endothelial responsiveness to alpha2-

adrenergic activation in canine blood vessels. The Physiologist 27: 282, 1984. 145. A-204 Katusic, Z., Shepher, J.T. and Vanhoutte, P.M. Oxytocin induces endothelium-dependent

relaxation of canine basilar arteries. The Physiologist 27: 282, 1984. 146. A-205 Houston, D.S. and Vanhoutte, P.M. Platelet activating factor induces endothelium-

independent relaxation of isolated canine blood vessels. The Physiologist 27: 282, 1984. 147. A-208 Vanhoutte, P.M. Effects of serotonin on endothelium-autonomic nerve endings and smooth

muscle cells. Int. J. Microcirc. 3: 465, 1984. 148. A-209 Rubanyi, G.M. and Vanhoutte, P.M. Hypoxia releases vasoconstrictor substance(s) from

the coronary endothelium. Circulation 70 (suppl. II): II-122, 1984. 149. A-211 Edoute, Y., Shepherd, J.T. and Vanhoutte, P.M. Effect of inorganic phosphate on

adrenergic neurotransmission in canine saphenous vein. Fed. Proc. 44: 1733, 1985. 150. A-212 Katusic, Z.S., Shepherd, J.T. and Vanhoutte, P.M. Anoxia causes endothelium-dependent

contractions of canine basilar artery. Fed. Proc. 44: 1587, 1985. 151. A-213 Houston, D.S. and Vanhoutte, P.M. Direct contraction and endothelium-mediated

relaxation of isolated canine coronary arteries by aggregating human platelets. Fed. Proc. 44: 1562, 1985.

152. A-214 Rubanyi, G.M., McLaran, C., Holmes, D., Vanhoutte, P.M. and Frye, R.L. Coronary

vasoconstriction induced by blood from patients with ischemic heart disease. Fed. Proc. 44: 1561, 1985.

153. A-215 Aarhus, L.L., Thome, S., Zander, J. and Vanhoutte, P.M. Prejunctional effects of

naftidrofuryl in canine saphenous veins. Fed. Proc. 44: 1248, 1985.

107

154. A-216 Vanhoutte, P.M. and Rubanyi, G.M. Ouabain inhibits endothelium-dependent relaxations to

arachidonic acid in canine coronary arteries. Fed. Proc. 44: 1234, 1985. 155. A-217 Luscher, T.F. and Vanhoutte, P.M. Interaction between S2-serotonergic and alpha1-

adrenergic receptors in the canine femoral artery. Fed. Proc. 44: 1230, 1985. 156. A-218 Zander, J., Edoute, Y. and Vanhoutte, P.M. Characterization of the pharmacological

properties of tulobuterol. Fed. Proc. 44: 1110, 1985. 157. A-219 Clothiaux, P.L., Wood, M.B. and Vanhoutte, P.M. Vascular reactivity of the isolated canine

tibia. Fed. Proc. 44: 1109, 1985. 158. A-220 Miller, V.M. and Vanhoutte, P.M. Endothelium-dependent responses can be modulated

chronically in canine arteries and veins. Fed. Proc. 44: 455, 1985. 159. A-221 Flavahan, N.A. and Vanhoutte, P.M. "Alpha-adrenoceptor reserve" and the effects of

cooling on alpha-adrenergic responses in canine femoral and saphenous veins. Fed. Proc. 44: 1903, 1985.

160. A-222 Lorenz, R.R. and Vanhoutte, P.M. Exocytotic release and pharmacological displacement of

3H-norepinephrine in canine bronchi. Fed. Proc. 44: 734, 1985. 161. A-224 Brum, J.M., Go, V.L.W., Vanhoutte, P.M. and Bove, A.A. Evidence for VIP-ergic control

of coronary vasoregulation. Regulatory Peptides, Suppl. 3: S37, 1985. 162. A-228 Katusic, Z.S., Shepherd, J.T. and Vanhoutte, P.M. Potassium causes endothelium-

dependent rhythmic activity in canine basilar artery. The Pharmacologist 27: 223, 1985. 163. A-229 Rubanyi, G.M., Schwartz, A. and Vanhoutte, P.M. The effect of diltiazem and verapamil on

endothelium-dependent responses in canine blood vessels. The Pharmacologist 27: 290, 1985. 164. A-230 Edoute, Y., Luscher, T.F. and Vanhoutte, P.M. Abnormalities in coronary circulation and

myocardial oxygen consumption in isolated hearts from spontaneously hypertensive rats. The Physiologist 28: 290, 1985.

165. A-231 Miller, V.M., Vanhoutte, V.J. and Vanhoutte, P.M. Endothelium-dependent responses in

aortae of reptiles. The Physiologist 28: 366, 1985. 166. A-232 Lüscher, T.F. and Vanhoutte, P.M. Endothelium-dependent responses to adenosine

diphosphate and serotonin in the aorta of spontaneously hypertensive and normotensive rats. The Physiologist 28: 270, 1985.

167. A-233 Flavahan, N.A., Miller, V.M. and Vanhoutte, P.M. Denervation augments alpha2- but not

alpha1-adrenergic responses in canine saphenous veins. The Physiologist 28: 308, 1985. 168. A-234 Gisclard, V. and Vanhoutte, P.M. Estrogens and endothelium-dependent responses in the

femoral artery of the rabbit. The Physiologist 28: 324, 1985.

108

169. A-235 Rubanyi, G.M. and Vanhoutte, P.M. Muscarinic receptor subtypes mediating the release of endothelium-derived relaxing factor(s) in canine femoral arteries. The Physiologist 28: 325, 1985.

170. A-236 Feletou, M. and Vanhoutte, P.M. Endothelium-derived relaxing factor(s) hyperpolarizes

coronary vascular smooth muscle. The Physiologist 28: 325, 1985. 171. A-237 Houston, D.S., Shepherd, J.T. and Vanhoutte, P.M. Endothelium-independent contraction of

canine coronary artery to aggregating human platelets. The Physiologist 28: 341, 1985. 172. A-238 McGoon, M.D., Vlietstra, R.E. and Vanhoutte, P.M. Hemodynamic response to intravenous

ketanserin in patients with pulmonary hypertension. Clin. Pharmacol. Ther. 35: 258, 1984. 173. A-239 Rubanyi, G.M. and Vanhoutte, P.M. Superoxide dismutase prolongs the half-life of

endothelium-derived relaxing factor(s). Clin. Res. 33: 522A, 1985. 174. A-240 Vanhoutte, P.M. and Rubanyi, G.M. Oxygen-derived free radicals and endothelium-

mediated relaxation in canine coronary arteries. Clin. Res. 33: 523A, 1985. 175. A-241 Vanhoutte, P.M. Platelets, serotonin and hypertension, a link? Thromb. Haemostas. 54:

321, 1985. 176. A-242 Lüscher, T.F. and Vanhoutte, P.M. Endothelium-dependent contractions to acetylcholine in

the aorta of spontaneously hypertensive rats. Hypertension 7: 843, 1985. 177. A-243 Rubanyi, G.M., Romero, J.C. and Vanhoutte, P.M. Effects of steady and pulsatile flow on

the production of prostacyclin and endothelium-derived relaxing factor in canine femoral arteries. Circulation 72: III-265, 1985.

178. A-244 Brum, J.M., Bove, A.A. and Vanhoutte, P.M. Participation of the endothelium in the

vasodilator effects of vasoactive intestinal peptide and substance P in the coronary arteries. Circulation 72: III-83, 1985.

179. A-245 Katusic, Z.S., Shepherd, J.T. and Vanhoutte, P.M. Endothelium-dependent contractions to

stretch in canine basilar arteries. Fed. Proc. 45: 289, 1986. 180. A-246 Lüscher, T.F., Aarhus, L.L., Rubanyi, G.M. and Vanhoutte, P.M. Effects of acetylcholine

and serotonin on coronary flow in isolated hearts of the spontaneously hypertensive rat. Fed. Proc. 45: 303, 1986.

181. A-247 Edoute, Y., Rubanyi, G.M. and Vanhoutte, P.M. Nickel chloride inhibits metabolic

coronary vasodilatation in isolated rat hearts. Fed. Proc. 45: 397, 1986. 182. A-248 Rubanyi, G.M., Schwartz, A. and Vanhoutte, P.M. Calcium-channel agonists stimulate the

release of endothelial relaxing factor from perfused canine femoral arteries. Fed. Proc. 45: 426, 1986.

183. A-249 Feletou, M. and Vanhoutte, P.M. Non-neurogenic relaxation to electrical stimulation in

canine coronary arteries is not due to free radicals. Fed. Proc. 45: 532, 1986.

109

184. A-250 O'Rourke, S.T. and Vanhoutte, P.M. Subtypes of muscarinic receptors in the canine saphenous vein. Fed. Proc. 45: 669, 1986.

185. A-251 Hoeffner, U., Aarhus, L.L. and Vanhoutte, P.M. Pharmacology of pentoxifylline in isolated

canine arteries and veins. Fed. Proc. 45: 670, 1986. 186. A-252 Miller, V.M., Reigel, M.M., Pennell, R.C., Hollier, L.H. and Vanhoutte, P.M. Endothelium-

dependent responses in veins grafted into the arterial circulation. Fed. Proc. 45: 767, 1986. 187. A-253 Houston, D.S. and Vanhoutte, P.M. Different serotonergic receptor subtypes on

endothelium and smooth muscle of canine coronary artery. Fed. Proc. 45: 787, 1986. 188. A-258 Cooke, J.P., Flavahan, N.A., Shepherd, J.T. and Vanhoutte, P.M. Differential contribution

of alpha1- and alpha2-adrenoceptors to contractile responses to norepinephrine in human limb arteries. Blood Vessels 23: 62, 1986.

189. A-259 Feletou, M. and Vanhoutte, P.M. Endothelium-derived factor(s) and membrane potential of

vascular smooth muscle. Blood Vessels 23: 68, 1986. 190. A-260 Flavahan, N.A. and Vanhoutte, P.M. Functional antagonism, receptor reserve and vascular

heterogeneity. Blood Vessels 23: 68, 1986. 191. A-261 Houston, D.S., Shepherd, J.T. and Vanhoutte, P.M. Mediators of platelet-induced responses

of coronary arteries. Blood Vessels 23: 76, 1986. 192. A-262 Luscher, T.F., Raij, L. and Vanhoutte, P.M. Functional properties of the vascular

endothelium in experimental hypertension. Blood Vessels 23: 87, 1986. 193. A-263 Miller, V.M. and Vanhoutte, P.M. Chronic increases in blood flow enhance endothelium-

dependent relaxation of canine blood vessels. Blood Vessels 23: 90, 1986. 194. A-264 Rubanyi, G.M. and Vanhoutte, P.M. Polarity of the release of endothelium-derived relaxing

factors. Blood Vessels 23: 98, 1986. 195. A-265 Vanhoutte, P.M., Lüscher, T.F., Cooke, J.P., Houston, D.S. and Neves, R. Endothelium-

dependent relaxations in human peripheral and renal arteries. Blood Vessels 23: 104, 1986. 196. A-266 Vanhoutte, P.M. Endothelium-dependent contracting factors. Int. J. Microcirc. 5: 169,

1986. 197. A-267 Vanhoutte, P.M. Platelets, serotonin and the hypertensive blood vessel wall. Int. J.

Microcirc. 5: 170, 1986. 198. A-277 Burnett, J.C., Jr., Rubanyi, G.M., Edwards. B.S., Schwab, T.R., Zimmerman, R.S. and

Vanhoutte, P.M. Effect of atrial natriuretic peptide on the coronary circulation in-vivo and in-vitro. Clin. Res. 34: 286A, 1986.

199. A-278 Blaise, G., Sill, J.C., Nugent, M., Van Dyke, R.A. and Vanhoutte, P.M. Isoflurane

attenuates epicardial coronary artery response to phenylephrine and PGF2_ in dogs. Anesth. Analg. 65: 520, 1986.

110

200. A-280 Luscher, T.F., Neves, R. and Vanhoutte, P.M. Endothelium-dependent relaxations to acetylcholine and adenosine diphosphate in human renal arteries. Kidney Int. 29: 251, 1986.

201. A-281 Luscher, T.F., Raij, L. and Vanhoutte, P.M. Decreased endothelium-dependent relaxations

to acetylcholine in the aorta of hypertensive Dahl rats. J. Am. Coll. Cardiol. 7: 245, 1986. 202. A-282 Cohen, R.A., Shepherd, J.T. and Vanhoutte, P.M. The endothelium of perfused canine

coronary arteries inhibits contractions due to 5-hydroxytryptamine and aggregating platelets. Clin. Res. 32: 156A, 1984.

203. A-284 Vanhoutte, P.M. Serotonin and the vascular wall. Angio. Archiv. 12: 41, 1986. 204. A-285 Marcelon, G., Balanant, Y., Pouget, G., Sablayrolles, S., Tisne-Versailles, J. and Vanhoutte,

P.M. Warming augments the pharmacological displacement of norepinephrine caused by ruscus in cutaneous veins. Angio. Archiv. 12: 100, 1986.

205. A-286 O'Rourke, S.T. and Vanhoutte, P.M. M2-muscarinic receptors mediate contraction of

canine bronchi by acetylcholine. The Pharmacologist 28: 157, 1986. 206. A-287 Flavahan, N.A. and Vanhoutte, P.M. Sympathetic purinergic vasoconstriction and

thermosensitivity in a canine cutaneous vein. The Pharmacologist 28: 135, 1986. 207. A-288 Vanhoutte, P.M. Reactivité de l'endothélium et du muscle lisse arteriel. J. de Maladies

Vasculaires 11 (Suppl. C): 98, 1986. 208. A-289 Hoeffner, U. and Vanhoutte, P.M. Arachidonic acid releases relaxing factor(s) from the

endothelium of canine blood vessels. The Physiologist 29: 153, 1986. 209. A-290 Miller, V.M. and Vanhoutte, P.M. Mechanism of augmented endothelium-dependent

relaxations to acetylcholine in fistula-operated canine arteries. The Physiologist 29: 158, 1986. 210. A-291 Feletou, M. and Vanhoutte, P.M. Electrical stimulation induced-relaxation of canine

coronary artery: possible involvement of dopaminergic receptor. The Physiologist 29: 165, 1986. 211. A-292 Rubanyi, E.L., Rubanyi, G.M., Romero, J.C. and Vanhoutte, P.M. Release of prostacyclin

and endothelium-derived relaxing factor by acetylcholine from canine femoral arteries. The Physiologist 29: 166, 1986.

212. A-293 Harker, C.T. and Vanhoutte, P.M. Myogenic response to cooling in the central ear artery of

the rabbit. The Physiologist 29: 181, 1986. 213. A-294 Lüscher, T.F., Vanhoutte, P.M., and Raij, L. Antihypertensive treatment normalizes

decreased endothelium-dependent relaxations in salt-induced hypertension of the rat. Circulation 74: II 286, 1986.

214. A-295 Shimokawa, H. and Vanhoutte, P.M. Reduced endothelium-dependent relaxations to

aggregating platelets and serotonin in porcine coronary arteries after previous endothelial injury. Circulation 74: II 413, 1986.

215. A-296 Rubanyi, G.M. and Vanhoutte, P.M. Na+-K+ pump and endothelium-dependent relaxation

of canine blood vessels. Fed. Proc., 46: 644, 1987.

111

216. A-297 Hoeffner, U. and Vanhoutte, P.M. Ouabain inhibits the effect of endothelium-derived

relaxing factor(s). Fed. Proc., 46: 644, 1987. 217. A-298 Iqbal, A. and Vanhoutte, P.M. The Ca2+-antagonist flunarizine inhibits endothelium-

dependent hpoxic facilitation through an action on vascular smooth muscle. Fed. Proc., 46: 645, 1987.

218. A-299 Feletou, M. and Vanhoutte, P.M. Ammonium ions and relaxation of vascular smoothmuscle

in vitro. Fed. Proc., 46: 650, 1987. 219. A-300 Stuart-Smith, K. and Vanhoutte, P.M. Regional differences in the effect of epithelium-

removal in three generations of canine airways. Fed. Proc., 46: 660, 1987. 220. A-301 Aarhus, L. L., Katusic, Z. S., Shepherd, J.T. and Vanhoutte, P.M. Arginine-vasopressin

causes edothelium-dependent relaxations of the canine cerebral resistance arteries. Fed. Proc., 46: 828, 1987.

221. A-302 Miller, V.M., Aarhus, L. L. and Vanhoutte, P.M. Estrogen modulates endothelium-

dependent responses to oxytocin in ovarian arteries of rabbits. Fed. Proc., 46: 828, 1987. 222. A-303 Katusic, Z.S., Shepherd, J.T. and Vanhoutte, P.M. Calcium ionophore A23187, arachidonic

acid and acetylcholine cause endothelium-dependent contractions in the canine basilar arteries. Fed. Proc., 46: 829, 1987.

223. A-304 Schryver, S.M., Bentley, M.D., Rubanyi, G.M., Romero, J.C. and Vanhoutte, P.M. Fed.

Proc., 46: 828, 1987. 224. A-305 Harker, G.T. and Vanhoutte, P.M. Sex-related differences in the effects of cooling on the

central artery of the rabbit ear. Fed. Proc., 46: 1121, 1987. 225. A-306 O'Rourke, S.T. and Vanhoutte, P.M. Heterogeneous prejunctional modulation of

norepinephrine release by ergonovine. Fed. Proc., 46: 1146, 1987. 226. A-307 Duprez, D., Essandoh, L.K., Vanhoutte, P.M. and Shepherd, J.T. Different peripheral

vascular responses during static exercise: role of muscle mass and relative tension. Fed. Proc., 46: 1405, 1987.

227. A-308 Janczewski, P.H. and Vanhoutte, P.M. Carteolol augments endothelium-dependent

relaxations to alpha2-adrenergic activation. Fed. Proc., 46: 1456, 1987. 228. A-311 Blaise, G.A., Sill, J.C., Nugent, M., Van Dyke, R.A. and Vanhoutte, P.M. Endothelial

damage abolishes isoflurane attenuation of PGF2alpha and 5HT-mediated canine coronary constriction. Anesthesioiogy, 65: A7, 1986.

229. A-313 Vanhoutte, P.M. Fentanyl and responsiveness of canine coronary arterial smooth muscle.

Canad. Anaesth. Soc. J., 33: S104, 1986.

112

230. A-314 Shimokawa, H., Lam, Jules Y.T., Bowie, E.J. Walter, Chesebro, James, H. and Vanhoutte, Paul M. Chronic Treatement with cod liver oil facilitates endothelium-dependent responsiveness in porcine coronary arteries. J. Am. Coll. Cardiol. 9: 210A, 1987.

231. A-319 Shimokawa, H., Lam, J. Y.T., Chesebro, J. H., Bowie, E.J. W. and Vanhoutte, P. M.

Platelets, unsaturated fatty acid and endothelium-derived relaxing factor(s). Thrombosis Research Suppl. VII: 9, 1987. Editors: H. R. Lijnen and M. Verstraete. New York, Pergamon Press, 1987.)

232. A-320 Harker, C.T. and Vanhoutte, P.M. Effects of hypoxia on contractions and endothelium-

dependent relaxations in aorta and femoral artery of the thirteen lined ground squirrel. The Physiologist, 30: 140, 1987.

233. A-321 Shimokawa, H., Kim, P. and Vanhoutte, P. M. Hypercholesterolemia impairs

endothelium-dependent relaxations to aggregating platelets in porcine basilar arteries. The Physiologist, 30: 179, 1987.

234. A-322 Vanhoutte, Paul M. and Shimokawa, Hiroaki. Effects of hypercholesterolemia on

heterogeneity in endothelium-dependent responsiveness in porcine arteries. The Physiologist, 30: 216, 1987.

235. A-323 Gao, Y.S. and Vanhoutte, P. M. Removal of the epithelium causes depolarization of canine

bronchial smooth muscle. The Physiologist, 30: 240, 1987. 236. A-326 O'Rourke, S.T. and Vanhoutte, P.M. Autonomic pharmacology of isolated canine

bronchial artery. The Pharmacologist, 29: 124, 1987. 237. A-327 Hoeffner, U. and Vanhoutte, P.M. Two different endothelium-derived relaxing factors are

released from canine arteries. The Pharmacologist, 29: 125, 1987. 238. A-328 Harker, C.T. and Vanhoutte, P.M. Effects of temperature, estrogen levels and the extract of

Ruscus Aculeatus in the saphenous vein of the rabbit. The Pharmacologist, 29: 126, 1987. 239. A-329 Feletou, M., Aarhus, L.L., Shepherd, J.T. and Vanhoutte, P.M. Ammonia induces relaxation

of small arteries from canine skeletal muscle. The Pharmacologist, 29: 127, 1987. 240. A-330 Flavahan, N.A., Vos, A.A.A.M. and Vanhoutte, P.M. Alpha1-adrenoceptor

subclassification in vascular smooth muscle of canine pulmonary arteries. The Pharmacologist, 29: 169, 1987.

241. A-331 Stuart-Smith, K. and Vanhoutte, P.M. Arachidonic acid evokes epithelium-dependent

relaxations of canine bronchi The Pharmacologist, 29: 174, 1987. 242. A-332 Boulanger, C.M. and Vanhoutte, P.M. Comparison of the alpha-adrenergic antagonistic

properties of buflomedil and CRL 41034 in canine saphenous vein. The Pharmacologist, 29: 196, 1987.

243. A-336 Kim, P., Shimokawa, H. and Vanhoutte, P. M. Effect of dietary unsaturated fatty acids on

endothelium-dependent responses in the porcine cerebral artery. Circulation (Part II, Suppl.). 76: IV-10, 1987.

113

244. A-337 Shimokawa, H. and Vanhoutte, P. M. Dietary supplementation with unsaturated fatty acids

augments endothelium-dependent relaxations in porcine coronary arteries. Circulation (Part II, Suppl.), 76: IV-10, 1987.

245. A-338 Kim, P., Sundt, T. M., Jr. and Vanhoutte, P. M. Differential alterations of endothelium-

dependent responses in chronic vasospasm after subarachnoid hemorrhage. Circulation (Part II, Suppl.), 76: IV-10, 1987.

246. A-339 Kim, P., Sundt, T. M., Jr. and Vanhoutte, P. M. Absence of mechanical stiffening of the

arterial wall in cerebral vasospasm after subarachnoid hemorrhage in dogs. Circulation (Part II, Suppl.), 76: IV-10, 1987.

247. A-340 Miller, V.M., Aarhus, L.L. and Vanhoutte, P.M. Effects of estrogens on adrenergic and

endothelium-dependent responses in the ovarian artery of the rabbit. Blood Vessels, 13: 42, 1988. 250. A-343 Shimokawa, H. and Vanhoutte, P.M. Impaired endothelium-dependent relaxation to

aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and in atherosclerosis. J. Am. Coll. Cardiol.: 2A, 1987.

251. A-344 Shimokawa, Hiroaki and Vanhoutte, P.M. Effects of dietary supplementation with cod-liver

oil on impaired endothelium-dependent relaxation in atherosclerotic porcine coronary arteries. J. Am. Coll. Cardiol: 191A, 1987.

252. A-345 Rogers, P J., Bauer, B.A , Brum, J.M., Bove, A.A. and Vanhoutte, P.M. Exercise training

and responsiveness of coronary arteries. J. Am. Coll. Cardiol: 246A, 1987. 253. A-346 Boulanger, Chantal, Lorenz, Robert R., Hendrickson, Helen and Vanhoutte Paul M.

Release of different relaxing factors by porcine endothelial cells in culture. FASEB J., 2: 104, 1988.

254. A-347 Katusic, Z.S. and Vanhoutte, P.M. Pharmacological analysis of relaxations to bradykinin

and NO in the canine basilar artery. FASEB J., 2: 108, 1988. 255. A-348 Miller, V.M. and Vanhoutte, P.M. Nitric oxide may not be the endothelium-derived

relaxing factor in canine veins. The FASEB Journal, 2: 109, 1988. 256. A-349 Guo, H., Lorenz, R.R. and Vanhoutte, P.M. Prevention of acetylcholine induced inhibition

of adrenergic neurotransmission by anisodamine. FASEB J., 2: 192, 1988. 257. A-350 Hoeffner, U. and Vanhoutte, P.M. Proximal and distal canine coronary artery segments

respond differently to endothelium-derived relaxing factor(s) but not to nitric oxide. FASEB J. 2: 1289, 1988.

258. A-351 Shimokawa, H., Lorenz, R.R. and Vanhoutte, P.M. Role of the endothelium in prostacyclin-

induced relaxation in porcine coronary arteries. FASEB J., 2: 1290, 1988. 259. A-352 Komori, K. and Vanhoutte, P.M. Effects of nitric oxide on electrical and mechanical

properties of smooth muscle cells of canine mesenteric and rabbit saphenous arteries. FASEB J., 2: 1291, 1988.

114

260. A-353 Auch-Schwelk, W. and Vanhoutte, P.M. Role of products of cyclo-oxygenase in endothelium-dependent contractions of the rat aorta to serotonin. FASEB J. 2: 1292, 1988.

261. A-354 Lorenz, R.R., Sanchez-Ferrer, C.F., Burnett, J.C. and Vanhoutte, P.M. Influence of

endocardial-derived factor(s) on the release of atrial natriuretic factor. FASEB J., 2: 1293, 1988. 262. A-355 Aarhus, L.L., Miller, V.M., McCullough, J.L., Bower, T.C. and Vanhoutte, P.M.

Endothelium-dependent responses in nonreversed (in situ) vein grafts. FASEB J., 2: 1294, 1988. 263. A-356 O'Rourke, S.T. and Vanhoutte, P.M. Studies on the mechanism of celiprolol-induced

vasodilatation. FASEB J., 2: 1788, 1988. 264. A-357 Vanhoutte, P.M. and Boulanger, C. Effect of the inhibition of Na+, K+ ATPase pump on

the relaxation induced by nitric oxide and nitroglycerin in the canine coronary artery. FASEB J., 2: 1820, 1988.

265. A-358 Harker, C.T. and Vanhoutte, P.M. Mechanisms of ammonium induced relaxation. FASEB

J., 2: 1823, 1988. 266. A-359 Vidal, M. and Vanhoutte, P.M. Endothelium-dependent effects of the converting enzyme

inhibitor trandolapril. FASEB J., 2: 2410, 1988. 267. A-360 Gao, Y. and Vanhoutte, P.M. Heterogeneity in sodium-potassium pump activity in canine

airway smooth muscle. FASEB J., 2: 2666, 1988. 268. A-361 Pearson, P J., Schaff, H. and Vanhoutte, P.M. Reperfusion after acute coronary occlusion in

dogs impairs endothelium-dependent relaxation to aggregating platelets. FASEB J., 2: 3923, 1988.

269. A-362 Tuncer, Meral and Vanhoutte, Paul M. Indomethacin augments the responsiveness to 5-

hydroxytryptamine in the perfused kidney of the normotensive rat. FASEB J., 2: 3930, 1988. 270. A-363 Lüscher, T.F., Diederich, D., Siebermann, R., Lehmann, A., Stultz, P., Buehler, F. R. and

Vanhoutte, P.M. Heterogeneity of endothelium-dependent relaxations in the human internal mammary artery, internal mammary vein and saphenous vein. FASEB J. 2: 6874, 1988.

271. A-364 Zellers, T.M. and Vanhoutte, P.M. Heterogeneity in endothelium-dependent and

independent responses of porcine pulmonary arteries. FASEB J., 2: 6875, 1988. 272. A-365 Stuart-Smith, K. and Vanhoutte, P.M. The airway epithelium of the pig releases both

relaxing and a contracting factor. FASEB J., 2: 7334, 1988. 273. A-366 Busk, M.F., Flavahan, N.A., Seta, J.P. and Vanhoutte, P.M. Methylxanthine, S 9795,

inhibits the bronchoconstrictor effect of 5-hydroxytryptamine, histamine and acetylcholine. FASEB J., 2: 7335, 1988.

274. A-367 Flavahan, N.A. and Vanhoutte, P.M. The release of ATP-evoked by transmural stimulation

of the canine saphenous vein. FASEB J., 2: 8737, 1988.

115

275. A-368 Busk, M.F., Seta, J.P. and Vanhoutte, P.M. The effect of S 9795 on cholinergic nerve endings in canine bronchi. Am. Review of Respiratory Disease, 137: 34, 1988.

276. A-369 Stuart-Smith, K. and Vanhoutte, P.M. Epithelium-dependent responses to arachidonic acid

in canine airways. Am. Review of Respiratory Disease, 137: 100, 1988. 277. A-374 Shimokawa, H. and Vanhoutte, P.M. Endothelium and hyperreactivity of

hypercholesterolemic, atherosclerotic porcine coronary arteries. Circulation 1987. 278. A-375 Miller, V.M. and Vanhoutte, P.M. Modulation of the responsiveness of endothelium and

arterial smooth muscle by estrogens. Circulation 1987. 279. A-376 Iqbal, A., Shimokawa, H. and Vanhoutte, P.M. Effect of hypoxia and hypercholesterolemia

on relaxations induced by isoproterenol and adenosine in pig coronary arteries. Circulation 1987. 280. A-377 Shimokawa, H. and Vanhoutte, P.M. Role of prostaglandins and free radicals in the

impaired endothelium-dependent responses in atherosclerotic porcine coronary arteries. Circulation 1987.

281. A-388 Komori, K., Miller, V.M., Flavahan, N., and Vanhoutte, P.M. Electrical properties of the

smooth muscle cells in canine saphenous veins before and after adrenergic denervation. FASEB J., 3:A899, 1989.

282. A-389 Miller, V.M. and Vanhoutte, P.M. Relaxations to nitric oxide and calcium ionophore

A23187 in the ventral aorta of trout. FASEB J., 3:A684, 1989. 283. A-390 Komori, K., Miller, V.M., and Vanhoutte, P.M. Electrophysiological effects of

endothelium-derived factors. Blood Vessels, 1989 ( 284. A-391 Miller, V.M., Flavahan, N.A., Gloviczki, P. and Vanhoutte, P.M. Effect of pertussis toxin

on endothleium-dependent and independent responses in canine veins and vein-grafts. Blood Vessels, 1989

285. A-392 Vidal-Ragout, M.J., Miller, V.M. and Vanhoutte, P.M. Dissociation between the production

of cyclic GMP and endothelium-dependent relaxations in canine systemic arteries and veins. Blood Vessels, 1989.

286. A-393 Miller, V.M. and Vanhoutte, P.M. Differential effects of chronic estrogen treatment on

endothelium-dependent and independent responses in rabbit arteries. The Physiologist 31:A4, 1988.

287. Error 288. Error 289. A-396 Miller, V.M., McCullough, J.M., Bower, T.C. and Vanhoutte, P.M. Endothelium-derived

relaxing factor and prostanoid production in "in situ" (nonreversed) vein grafts. Clin. Res. 35:543A, 1988.

290. A-397 Miller, V.M., Aarhus, L.L., and Vanhoutte, P.M. Effects of estrogens on adrenergic and

endothelium-dependent responses in the ovarian artery of the rabbit. Blood Vessels 25:42, 1988.

116

291. A-398 Auch-Schwelk, W. and Vanhoutte, P.M. Endothelium-derived contracting factor released

by serotonin in the SHR aorta. American Journal of Hypertension: 20A. 292. A-399 Auch-Schwelk, W., Katusic, Z.S. and Vanhoutte, P.M. Oxygen-derived free radical-

induced contractions are augmented in chronic hypertension. Hypertension: 350, 1988. 293. A-401 Shimokawa, H. and Vanhoutte, P.M. Natural course of the impairment of endothelium-

dependent relaxations after balloon endothelium-removal in porcine coronary arteries. Circulation Suppl. Part II 78: 170, 1988.

294. A-402 Shimokawa, H., Flavahan, N.A. and Vanhoutte, P.M. Impaired Gi Protein function may

account for endothelial dysfunction in regenerated state and in hypercholesterolemia. Circulation Suppl. Part II 78: 475, 1988.

295. A-403 Katusic, Z.S. and Vanhoutte, P.M. Oxygen-derived free radicals cause endothelium-

dependent contractions of canine cerebral arteries. Circulation Suppl. Part II 78: 451, 1988. 296. A-404 Gao, Y. and Vanhoutte, P.M. Influence of the epithelium on the accessibility of

intraluminal bronchoactive agents to canine airway smooth muscle. FASEB J., 3:A972, 1989. 297. A-405 Auch-Schwelk W. and Vanhoutte, P.M. Contractions to endothelin in isolated arteries of

SHR and WKY rats. FASEB J., 3:A1008, 1989. 298. A-406 Guo, H., Lorenz, R.R. and Vanhoutte, P.M. Anisodamine is a non-selective inhibitor of pre-

and post-junctional muscarinic receptors in canine saphenous veins. FASEB J., 3:A889, 1989. 299. A-407 Behrends, S., Hoeffner, U., Goetz, A.E., Peter, K., Brendel, W. and Vanhoutte, P.M. Shock

waves do not alter vascular tone of isolated rabbit carotid artery segments. FASEB J., 3:A1193, 1989.

300. A-408 Katusic, Z.S and Vanhoutte, P.M. Hydrogen peroxide causes endothelium-dependent

contractions in canine cerebral arteries. FASEB J., 3:A1177, 1989. 301. A-409 Busk, M.F. and Vanhoutte, P.M. Theophylline, causes the release of epithelium-derived

relaxing factor. FASEB J., 3:A274, 1989. 302. A-410 Boulanger, C., Schini, V.B. and Vanhoutte, P.M. Effect of chronic exposure to

eicosapentaenoic acid on the release of relaxing factor and the production of cyclic GMP by cultured endothelial cells. Journal of Vascular Medicine and Biology 1: 79, 1989.

303. A-411 Auch-Schwelk, W., Katusic, Z.S. and Vanhoutte, P.M. Endothelium-dependent contractions

in the SHR aorta are inhibited by thromboxane A2 receptor antagonists. Journal of Vascular Medicine and Biology 1: 76, 1989.

304. A-412 Katusic, Z.S. and Vanhoutte, P.M. Endothelium-dependent contractions to NG-mono-

methyl-L-arginine in the canine basilar artery. Journal of Vascular Medicine and Biology 1: 75, 1989.

117

305. A-413 Schini, V.B., Boulanger, C., Regoli, D. and Vanhoutte, P.M. Bradykinin induces release of endothelium-dependent relaxing factor(s) via activation of B2 receptors in porcine aortic endothelial cells in culture. Journal of Vascular Medicine and Biology 1: 112, 1989.

306. A-414 Flavahan, N.A. and Vanhoutte, P.M. Differential inhibitory effects of phorbol esters on

endothelium-dependent relaxations in canine coronary arteries. Journal of Vascular Medicine and Biology 1: 86, 1989.

307. A-415 Lorenz, R.R., Miller, V.M. and Vanhoutte, P.M. Endothelium does not increase the release

of tritiated-norepinephrine in canine saphenous veins. Journal of Vascular Medicine and Biology 1: 100, 1989.

308. A-416 Miller, V.M., Komori, K. and Vanhoutte, P.M. Responses of canine veins to endothelin.

Journal of Vascular Medicine and Biology 1: 104, 1989. 309. A-417 Shimokawa, H., Flavahan, N., Lorenz, R. and Vanhoutte, P.M. Prostacyclin releases

endothelium-derived relaxing factor and potentiates its action in coronary arteries of the pig. Journal of Vascular Medicine and Biology 1: 115, 1989.

310. A-418 Vanhoutte, P.M., Shimokawa, H. and Flavahan, N.A. Pertussis toxin inhibits endothelium-

dependent responses in canine arteries. The Physiologist 31:A3, 1988. 311. A-419 Gao, Y. and Vanhoutte, P.M. Sodium-calcium exchange in canine airway smooth muscle.

The Physiologist 31:A139, 1988. 312. A-420 Guo, H.-Y., Lorenz, R.R. and Vanhoutte, P.M. Effect of S-11701 on adrenergic

neuroeffector interaction in isolated canine saphenous veins. The Physiologist, 31: A56, 1988. 313. A-421 Vidal, M. and Vanhoutte, P.M. Heterogeneity of endothelium-dependent responses to

acetylcholine in canine coronary and femoral arteries. The Physiologist 31:A208, 1988. 314. A-422 Flavahan, N.A. and Vanhoutte, P.M. Characterization of different endothelium-dependent

relaxing factors released from canine arteries. The Physiologist, 31:A3, 1988. 315. A-423 Komori, K., Shimokawa, H. and Vanhoutte, P.M. Dietary modulation of endothelium-

dependent responses to aggregating platelets in porcine femoral veins. The Physiologist, 31:A4, 1988.

316. A-424 Katusic, Z.S. and Vanhoutte, P.M. Superoxide anion mediates endothelium-dependent

contractions to calcium ionophore A23187 in the canine basilar artery. The Physiologist, 31: A3, 1988.

317. A-425 Boulanger, C. and Vanhoutte, P.M. Porcine endothelial cells in culture release different

relaxing factors. The Physiologist, 31:A208, 1988. 318. A-426 Lorenz, R.R., Gao, Y. and Vanhoutte, P.M. The effect of epithelium removal on airway

contractility is not mediated by arachidonic acid metabolites or nitric oxide. The Physiologist, 31:A124, 1988.

118

319. A-427 Vidal-Ragout, M., Lorenz, R.R., Bentley, M., Romero, J.C. and Vanhoutte, P.M. Endothelium-derived relaxing factor modulates renin secretion. Clin. Res., 36:546A, 1988.

320. A-428 Boulanger, C., Schini, V.B. and Vanhoutte, P.M. Production of cyclic GMP by bradykinin,

adenosine diphosphate, the calcium ionophore A23187 and nitric oxide in cultured porcine aortic endothelial cells. Journal of Vascular Medicine and Biology 1: 162, 1989.

321. A-429 Flavahan, N.A., Shimokawa, H. and Vanhoutte, P.M. Endothelium-dependent relaxations:

regulation by a pertussis toxin-sensitive G-protein. Journal of Vascular Medicine and Biology 1: 170, 1989.

322. A-430 Kim, P., Sundt, T.M. Jr. and Vanhoutte, P.M. Endothelium-dependent responsiveness in the

spastic cerebral arteries after subarachnoid hemorrhage. Journal of Vascular Medicine and Biology 1: 181, 1989.

323. A-431 Vanhoutte, P.M., Janczewski, P.H. and Boulanger, C. Carteolol augments endothelium-

dependent relaxations to alpha2 adrenergic activation. Journal of Vascular Medicine and Biology 1: 206, 1989.

324. A-432 Eber, B., Biondi, M.L., Auch-Schwelk, W. and Vanhoutte, P.M. IGM-anticardiolipin-

antibodies evoke endothelium-independent relaxations in isolated canine coronary arteries. The Physiologist, 32: 189, 1989.

325. A-433 Gao, Y. and Vanhoutte, P.M. Lowering the PO2 or cooling induces epithelium-dependent

relaxations of canine bronchi. The Physiologist, 32: 227, 1989. 326. A-436 Lorenz, R.R. and Vanhoutte, P.M. Endothelium-dependent effects of perindoprilat.

Cardiovascular Drugs & Therapy, 3: 606, 1989. 327. A-437 Morrison, K., Flavahan, N.A. and Vanhoutte, P.M. The effects of nicorandil on canine

arteries and veins. Cardiovascular Drugs and Therapy, 3: 613, 1989. 328. A-438 Janczewski, P., Boulanger, C., Iqbal, A., Vanhoutte, P.M. Endothelium-dependent effects of

carteolol. Cardiovascular Drugs and Therapy, 3: 655, 1989. 329. A-440 Katusic, Z.S., Shepherd, J.T. and Vanhoutte, P.M. Mechanisms of endothelium-dependent

relaxations to vasopressin in cerebral arteries. Journal of Vascular Medicine and Biology, 1: 180, 1989.

330. A-441 Boulanger, C., Vidal-Ragout, M., Fiksen-Olsen, M., Romero, J.C. and Vanhoutte, P.M.

Cultured endothelial cells release a non-prostanoid inhibitor of renin release. Journal of Vascular Medicine and Biology, 1: 207, 1989.

331. A-442 Miller, V.M., Flavahan, N.A., Gloviczki, P. and Vanhoutte, P.M. Effect of pertussis toxin

on endothelium-dependent and independent responses in canine veins and vein-grafts. Journal of Vascular Medicine and Biology, 1: 289, 1989.

332. A-443 Komori, K., Miller, V.M. and Vanhoutte, P.M. Electrophysiological effects of endothelium-

derived factors. Journal of Vascular Medicine and Biology, 1: 182, 1989.

119

333. A-444 Schini, V., Dewey, J. and Vanhoutte, P.M. Effect of indapamide on endothelium-dependent and independent relaxation of canine femoral arteries. Journal of Vascular Medicine and Biology. 1: 198, 1989.

334. A-445 Shimokawa, H. and Vanhoutte, P.M. Effects of endothelial regeneration and diets on

endothelium-dependent relaxations in porcine coronary arteries. Journal of Vascular Medicine and Biology. 1: 201, 1989.

335. A-446 Zellers, T.M. and Vanhoutte, P.M. Heterogeneity of endothelium-dependent and

independent responses to aggregating platelets in porcine pulmonary arteries. Clin. Res., 36:590A, 1989.

336. A-447 Busk, M.F., Flavahan, N.A., Seta, J.P. and Vanhoutte, P.M. The methylxanthine, S9795,

causes the release of an epithelium-derived relaxing factor. Clin. Res., 36:592A, 1988. 337. A-448 Flavahan, N.A. and Vanhoutte, P.M. Fluoride causes endothelium-dependent relaxation of

canine coronary arteries. The Pharmacologist, 31: 171, 1989. 338. A-450 Vanhoutte, P.M., Hendrickson, H. and Boulanger, C. Effect of chronic exposure to

eicosapentaenoic acid on the release of relaxing factor from cultured endothelial cells. The FASEB Journal, 3:A532, 1989.

339. A-451 Schini, V.B., Boulanger, C., Regoli, D. and Vanhoutte, P.M. Production of cyclic GMP by

kinins in cultured porcine aortic endothelial cells. The FASEB Journal, 3: A533, 1989. 340. A-454 Auch-Schwelk, W., Katusic, Z.S., and Vanhoutte, P.M. Endothelium-Dependent

contractions to Acetylcholine in the SHR Aorta are Augmented During Inactivation of Endothelium-Derived Relaxing Factor. J. Amer. College of Cardiology, 15, 67A, 1990.

341. A-457 Vanhoutte, P.M. and Pearson, P.J. Repersion after acute coronary occlusion in Dogs acutely

and chronically impairs endothelium-dependent relaxation to aggregating platelets. Cardiovasc. Drugs and Therapy 3: pg. 895, 1989.

342. A-460 Schini, V.B., Katusic, Z.S., and Vanhoutte, P.M. Oxytocin, [Arg8]-vasopressin and

tachykinins evoked the production of cyclic GMP in porcine aortic endothelial cells. FASEB J. 4, A415, 1990.

343. A-461 Kim, N.D., Schini, V.B. and Vanhoutte, P.M. Comparison of endothelin-1 and endothelin-3

induced contractions in SHR and Wistar rat aorta. FASEB . 4, A1081, 1990. 344. A-463 Auch-Schwelk W., Katusic Z.S., Vanhoutte P.M. Pharmacology of Endothelium-

Dependent Contractions to Acetylcholine in the SHR Aorta. Arch. Intern. Pharmacodyn. Ther. 305: 228, 1990.

345. A-464 Miller V.M. and Vanhoutte P.M. Hormonal modulation of endothelium-dependent

responses: role of guanine nucleotide regulatory proteins. Arch. Intern. Pharmacodyn. Ther. 305: 267, 1990.

346. A-465 Schini V.B., Bond R.A., Vanhoutte P.M. L-Arginine induces endothelium-dependent and

independent relaxations of tolerant rat aortas. Arch. Intern. Pharmacodyn. Ther. 305: 277, 1990.

120

347. A-466 Vilaine J.P., Bondi M., Villeneuve N., Feletou M., Peglion J.L., Vanhoutte P.M. The

calcium antagonist S11568 causes endothelium-dependent relaxation in canine arteries. Arch. Intern. Pharmacodyn. Ther. 305: 291, 1990.

348. A-467 Bond R.A., Kenakin T.P. and Vanhoutte P.M. Functional pharmacologic receptor

classification: are the problems real or theoretical? Eur. J. Pharmacol. 183, 82, 1990. 349. A-468 Vanhoutte P.M. Endothelium-derived Relaxing and Contracting Factor: pathological and

therapeutic implications. Eur. J. Pharmacol. 183, 109, 1990. 350. A-469 Mombouli J-V., Rafla E. and Vanhoutte P.M. Effects of angiotensin converting enzyme

inhibitor: cilazapril, on arterial endothelium-dependent responses. Eur. J. Pharmacol. 183,698, 1990.

351. A-470 Morrison K.J. and Vanhoutte P.M. Relaxations induced by arachidonic acid in airway

smooth muscle. Eur . J. Pharmacol., 183, 1191, 1990. 352. A-471 Schini V.B, Kim N.D. and Vanhoutte P.M. Endothelium-dependent modulation of the

contractions evoked by endothelin-1, endothelin-3 and phenylephrine in SHR and wistar rat aorta. Eur. J. Pharmacol. 183, 1815, 1990.

353. A-472 Vanhoutte P.M. Endothelium-derived relaxing and contracting factors. Eur. J. Pharmacol. ,

183, 2088, 1990. 354. A-473 Ruff F., Santais M.C., Callens E., Naline E., Advenier C. and Vanhoutte P.M. Beta-2

adrenergic actions of tulobuterol and its metabolites on airway smooth muscle. Eur. J. Pharmacol. 183, 2130, 1990.

355. A-474 Vanhoutte P.M. Endothelium-derived contracting factors. International Journal of

Microcirculation 9(Suppl 1): 171, 1990. 356. A-475 Vanhoutte P.M. Endothelium, Platelets and Vascular Occlusion 357. A-476 Auch-Schwelk W, Katusic Z.S., Vanhoutte P.M. Pharmacological properties of the

contracting factor released by the endothelium in the SHR aorta. Eur. Heart J., 11: 265, 1990. 358. A-478 Nagao T and Vanhoutte PM Hyperpolarization contributes to endothelium-dependent

relaxations in the rat femoral vein. Circulation Supplement III; 82, 344. 359. A-479 Pearson PJ, Lin PJ, Schaff HV, and Vanhoutte PM Augmented Endothelium-dependent

Hypoxic Contractions In Vivo and In Vitro Early Following Coronary Reperfusion Injury. Circulation Supplement III; 82, 506.

360. A-482 Vanhoutte, P.M. Vascular Effects of Ischemia and Serotonin. Journal of Vascular Diseases

Supplement 30, 25, 1990 361. A-484 T. Scott-Burden, T.J. Resink, A.W.A. Hahn, F.R. Buhler and P.M. Vanhoutte. Induction of

growth factor expression by endothelin in vascular smooth muscle cells may be regulated by angiotensin II. J. Vasc. Med. Biol., 2, 175, 1990.

121

362. A-485 Schini V.B., Kim N.D. and Vanhoutte P.M. Endothelin-1 and endothelin-3 evoke

endothelium-dependent relaxations in aortas from normotensive and hypertensive rats. J. Vasc. Med. Biol. 2, 179, 1990.

363. A-488 Eber, B., Biondi, M.L., Auch-Schwelk, W., Vanhoutte, P.M. Anticardiolipin-antibodies

relax coronary vascular smooth muscle. FASEB J., 4, A596, 1990. 364. A-489 Nagao, T. and Vanhoutte, P.M. Endothelium-dependent relaxations resistant to nitro-L-

arginine are mediated by endothelium-dependent hyperpolarizations in porcine coronary arteries. FASEB J., 5, A1417 ,1991.

365. A-490 Gao, Y., Schini, V.B. and Vanhoutte, P.M. The Epithelium-Dependent Potentiation of

Relaxation of Canine Bronchi to Isoproterenol is not mediated by cyclic nucleotides. FASEB J.5, A1056, 1991.

366. A-491 Bond, R.A., Smart, F.W. and Vanhoutte, P.M. Responses to norepinephrine in porcine

coronary arteries. FASEB J. 5, A1219, 1991. 367. A-492 Morrison, K.J. and Vanhoutte, P.M. Characterization of Muscarinic Receptors in Guinea-

Pig Trachea. FASEB J. 5, A1241, 1991. 368. A-493 Junquero, D.C., Schini, V.B., Scott-Burden, T. and Vanhoutte,P.M. Interleukin-1ß Induces

the Production of a Smooth Muscle-Derived Relaxing Factor. FASEB J. 5, A1607, 1991. 369. A-494 Schini, V.B., Scott-Burden, T. and Vanhoutte, P.M. Interleukin-1ß Stimulates the

Production of a Stable Factor that Induces the Accumulation of Cyclic GMP in Cultured Vascular Smooth Muscle Cells. FASEB J.,5, A1607, 1991.

370. A-495 Scott-Burden, T., Mackie, E.J., Hahn, A.W.A. and Vanhoutte, P.M. The Influence of

Vasoconstrictor Peptides on Extracellular Matrix Glycoconjugate Synthesis by Cultured Vascular Smooth Muscle Cells. FASEB J., A1609, 1991.

371. A-496 Illiano, S.C., Mombouli, J.V., Nagao, T. and Vanhoutte, P.M. Converting Enzyme Inhibitors

Potentiate Hyperpolarizations and Nitric Oxide-Independent Relaxations Induced by Bradykinin. FASEB J., 5, A1727, 1991.

372. A-497 Mombouli, J-V. and Vanhoutte, P.M. Perindoprilat Amplifies Endothelium-Dependent

Relaxations to Bradykinin and Unmasks Those to Kininogen. FASEB J., 5, A1417, 1991. 373. A-498 Weigert, A.L., Schini, V.B. and Vanhoutte, P.M. Lipopolysaccharide Causes Relaxation of

the Rat Aorta by Inducing the L-Arginine-Nitric Oxide Pathway in Smooth Muscle. FASEB J., 5, A385, 1991.

374. A-499 Gräser, T and Vanhoutte, P.M. Role of Cyclic GMP in Endothelium-Dependent Hypoxic

Contraction of Canine Coronary Arteries. FASEB J., 5, A385, 1991. 375. A-500 Mombouli, J-V, Nagao, T., Illiano, S. and Vanhoutte, P.M. Does local generation of kinins

mediate the endothelium-dependent relaxations to converting enzyme inhibitors in isolated canine arteries? Cardiovascular Drugs and Therapy, Supplement 3, 349, 1991.

122

376. A-501 Auch-Schwelk, W., Katusic, Z.S. and Vanhoutte, P.M. Inactivation of endothelium-derived

relaxing factor augments endothelium-dependent contractions to acetylcholine in the SHR aorta. J Hypertension, 8 (suppl 3):S84, 1990.

377. A-503 Gao Y., Nagao T., Bond R.A., Janssens W. and Vanhoutte, P.M. Characterization of

endothelium-dependent relaxations induced by nebivolol in canine coronary arteries. Br J Pharmacol 102:312P, 1991.

378. A-504 Gao, Y., Nagao, T., Bond, R.A., Janssens, W.J. and Vanhoutte, P.M. Nebivolol Induces

Endothelium-Dependent Relaxations of Canine Arteries. Drug Investigation 3(Suppl. 1):118-119, 1991.

379. A-515 Morrison, K.J .and Vanhoutte, P.M. Inhibition of aiway smooth muscle tone by phorbol

ester in guinea-pig trachea. Am. Rev. Respir. Dis.,143: A341, 1991. 380. A-516 Morrison, K.J. and Vanhoutte, PM. Possible involvement of protein kinase C in modulation

of airway smooth muscle reactivity by epithelium. FASEB J., 4: A841, 1990. 381. A-517 Gao, Y. and Vanhoutt,e P.M. Contraction-level and epithelium-dependent relaxations

induced by lowering PO2 in canine bronchi. Am. Rev. Respir. Dis., 141 : A914, 1990. 382. A-518 Gao, Y. and Vanhoutte, P.M. Cooling induces epithelium-dependent contractions of canine

bronchi. FASEB J 4:A841, 1990. 383. A-519 Scott-Burden, T., Mackie, E.J. and Vanhoutte, P.M. Angiotensin and vascular structure:

modulation of extracellular matrix synthesis in cultured smooth muscle cells. In: Current Advances in Ace Inhibition II, 134, 1991.

384. A-520 Durante, W., Schini, V.B., Scott-Burden, T., Junquero, D.C., Kroll, M.H., Vanhoutte, P.M.

and Schafer, A.I. Platelet products (TGF-ß1 and PDGF) inhibit the induction of nitric oxide synthase activity in cultured vascular smooth muscle cells. Blood 78:395a, 1991.

385. A-521 Durante, W., Schini, V.B., Scott-Burden, T., Junquero, D.C., Kroll, M.H., Vanhoutte, P.M.

and Schafer, A.I. Inhibition of Platelet activation by an L-arginine derived substance released by cultured vascular smooth muscle cells treated with interleukin-1ß. Blood 78:141a, 1991.

386. A-522 Nagao, T. and Vanhoutte, P.M. Mechanism of Anoxic Contraction in Canine Basilar

Artery. FASEB J 4: A684, 1990. 387. A-526 Vanhoutte, P.M. Endothelium-Derived Relaxing and Contracting Factors. J Vasc Med Biol,

3:76, 1990. 388. A-527 Weigert, A.L., Schini, V.B., Bond, R. and Vanhoutte, P.M. Basal Release of nitric oxide

modulates the relaxing effect of isoproterenol (ISO) in the aorta of the rat. FASEB. J., 6: A-1509, 1991.

389. A-528 Morrison, K.J. and Vanhoutte, P.M. Ouabain inhibits relaxation induced by vasoactive

intestinal peptide in guinea-pig isolated trachea. FASEB. J., 6:A-1586, 1991.

123

390. A-529 Bond, R.A., Smart, F.W., Morrison, K.J., Roberts, R. and Vanhoutte, P.M. Effect of chronic dietary supplement- ation with NC 020, a defined fish oil, on relaxation induced by norpinephrine in porcine coronary artery. FASEB. J., 64:A-1581, 1991.

391. A-530 Smart, F.W., Bond, R.A., Geske, R. Morrison, K.J., Roberts, R. and Vanhoutte, P.M. Effect

of balloon abrasion and dietary supplementation with NC 020, a defined fish oil, on relaxations induced by 5-hydroxytryptamine in porcine coronary artery. FASEB. J., 6:A-1581, 1991.

392. A-531 Boulanger, C.M. and Vanhoutte, P.M. Effect of interleukin-2 on contractions to arachidonic

acid in rat aorta. FASEB. J Part II., 6:A-1457, 1991. 393. A-532 Hoshino, Y., Morrison, K.J. and Vanhoutte, P.M. Endothelium-dependent and

endothelium-independent hypoxic contraction of canine pulmonary artery. FASEB. J., 6:A-1179, 1991.

394. A-533 Scott-Burden, T., Schini, V.B., Junquero, D.C., Elizondo, E. and Vanhoutte, P.M. Growth

factor stimulated proliferation of cultured smooth muscle cells is inhibited by interleukin-1ß-induced nitric oxide production. FASEB. J.,; 6:A-1603, 1991.

395. A-534 Gao, Y. and Vanhoutte, P.M. The epithelium modulates the responses of the guinea-pig

trachea to hydrogen peroxide. FASEB J., 6(:A-1818, 1991. 396. A-535 Shibano, T. and Vanhoutte, P.M. Induction of an L-arginine: nitric oxide pathway in

porcine coronary artery. FASEB J., 6:A-1803, 1991. 397. A-536 Joly, G.A., Schini, V.B. and Vanhoutte, P.M. Endothelial denudation of the rat carotid

artery, in vivo, induces nitric oxide synthase activity. FASEB J., 6:A-1732, 1991. 398. A-537 Junquero, D.C., Schini, V.B., Scott-Burden, T. and Vanhoutte, P.M. Interleukin-1ß evokes

a greater loss of aortic tone in SHR than in WKY rats by inducing a larger production of nitric oxide. FASEB J., 6:A-1733, 1991.

399. A-538 Schini, V.B., Scott-Burden, T., Durante, W., Elizondo, E., Schafer, A. and Vanhoutte, P.M.

Eicosapentaenoic acid (EPA) enhances the activity of nitric oxide synthase evoked by interleukin-1 ß (IL-1 ß) in cultured smooth muscle cells from human aorta. FASEB J., 6:A-1732, 1991.

400. A-539 Mombouli, J.-V. and Vanhoutte, P.M. Endothelium-dependent relaxations and contractions

to ADP and ATP in rat aorta and in canine coronary arteries. FASEB J., 6:A-2017, 1991. 401. A-545 Junquero, D.C., Schini, V.B., Scott-Burden, T. and Vanhoutte, P.M. The expression by

interleukin-1ß of the inducible nitric oxide synthase activity in vascular smooth muscle is augmented in spontaneously hypertensive rats. Am J Hypertension 5:3A-4A, 1992.

402. A-578 Desta, B., Clozel, J.P., Boulanger, C.M., Vanhoutte, P.M. Chronic treatment with the Ca2+

channel inhibitor RO 40-5967 potentiates endothelium-dependent relaxations in the aorta of the hypertensive salt sensitive dahl rat. The Pharmacologist, 35 (n°3) : p. 160, 1993.

403. Error

124

404. A-582 Scott-Burden, T., Elizondo, E., Ge, T., Boulanger, C.M., and Vanhoutte, P.M. Protein kinase C and Adenylate cyclase regulate NO production by cultured smooth muscle cells. Endothelium, 1: S1-S104, 1993.

405. A-587 Boulanger, C.M., Morrison, K.J., Vanhoutte, P.M. M3-Muscarinic receptors mediate both

endothelium-dependent contraction and relaxation to acetylcholine in the aorta of the spontaneously hypertensive rat. Canadian Journal of Physiology and Pharmacology, 72, Supplement 1: 1, 1994.

406. A-589 Ge, T., Hughes, H., Junquero, D.C., Wu,

K.K., Vanhoutte, P.M. Augmented expression and activity of prostaglandin H synthase in SHR aorta. FASEB J., 8, 1994.

407. A-590 Day, N.S., Ge, T., Codina, J., Birnbaumer, L., Vanhoutte, P.M. and Boulanger, C.M.

Expression of Gi- Proteins in cultured endothelial cells with impaired release of relaxing factors. FASEB J., 8, 1994.

408. Error 409. A-596 Day, N.S., Ge, T., Codina, J., Birnbaumer, L., Vanhoutte, P.M., et Boulanger, C.M.

Gi Proteins and the Response to Serotonin in Cultured Porcine Endothelial Cells with Impaired EDRF Release. Journal of Endothelium Cell Research, 2: 18, 1995.

410. A-597 Ge, T., Vanhoutte, P.M. and Boulanger, C.M.

Increased Response to PGH2 contributes to Endothelium-dependent Contractions in SHR Aorta.Journal of Endothelium Cell Research, 2: 27, 1995.

411. A-598 Mombouli, J.V., Chelly, F., Alvear, J., Ibrahim, B., Kilbourn, R. and Vanhoutte, P.M.

Alterations in Coronary Endothelial Vasodilator Mediators following Endotoxemia in Dogs. Journal of Endothelium Cell Research, 2: 62, 1995.

412. A-599 Mombouli, J.V., Ibrahim, B. and Vanhoutte, P.M. Interactions between Kinins and Ace-

Inhibitors in Canine Arteries. Journal of Endothelium Cell Research, 2: 63, 1995. 413. A-600 Vanhoutte, P.M. Endothelial Dysfunction in Cardiovascular Disease. Journal of

Endothelium Cell Research, 2: 90, 1995. 414. A-601 Vanhoutte, P.M. Endothelium-Derived Vasoactive Factors in Hypertension. Am J

Hypertens.,8: 28,1995. 415. A-614 Vanhoutte, P.M. Endothelial dysfunction in cardiovascular diseases. Pharmacological

Research, 31: 151, 1995. 416. A-615 Nonotte, I., Verbeuren, T.J., Fabiani, J.N. and Vanhoutte, P.M. Production of extracellular

matrix by smooth muscle cells from human varicose veins. Pharmacological Research, 31: 307, 1995.

417. A-616 Vanhoutte, P.M. Impaired endothelium-dependent vasodilata-tion in heart failure. Journal of

Molecular and Cellular Cardiology, 6: A334, 1995.

125

418. Error 419. A-629 Vanhoutte, P.M. Endothelial dysfunction and cardiovascular disease. Meth. Find. Exp. Clin.

Pharmacol. 17(A): 31-32, 1995. 420. A-633 Mombouli, J.V., Bissiriou, I., Desta, B., Ballard, K., Vanhoutte, P.M. Potentiation of

kininase II-resistant kinins by ACE-inhibitors. Circulation, 92:796, 1995. 421. A-634 Mombouli, J.V., Nakashima, M., Hamra, M., Vanhoutte, P.M. Exercise-training enhances

endothelium-dependent relaxtions and hyperpolarization evoked by bradykinin. Circulation 92: 3614, 1995.

422. A-635 Mombouli, J.V., Bissiriou, I., Vanhoutte, P.M. Circulation, 92: 3609, 1995. 423. A-636 Borg-Capra, C., Fournet-Bourguignon, M.P., Janiak, P., Villeneuve, N., Bidouard, J.P.,

Vilaine, J.P., Vanhoutte, P.M. Régénération endothéliale après dénudation de coronaires de porc: chronologie des événements études morphologiques et fonctionnelles. Archives des maladies du Coeur et des Vaisseaux, 32, 1995.

424. A-637 Perrault, L.P., Bidouard, J.P., Lesage, L., Reure, H., Delescluse, I., Janiak, P., Villeneuve,

N., Canovi, C., Jacquemin, C., Vilaine, J.P., Vanhoutte, P.M. Dysfonction endothéliale et artériosclérose accélérée après greffe cardiaque: chronologie des événements. Archives des maladies du Coeur et des Vaisseaux, 35, 1995.

425. A-638 Corriu, C., Félétou, M., Canet, E., Vanhoutte, P.M. Endothelium-dependent

hyperpolarization and cytochrome P450 monooxygénases (P450) inhibitors. FASEB J., 10: A10, 1996.

426. A-639 Nakashima, M., Vanhoutte, P.M. Membrane hyperpolarization and relaxation of canine

blood vessels to vasoactive intestinal polypeptide. FASEB J., 10 : A69, 1996. 427. A-640 Perrault, L.P., Bidouard, J.P., Janiak, P., Villeneuve, N., Vilaine, J.P., Vanhoutte, P.M.

Impairment of G-protein function and endothelial dysfunction after heart transplantation. FASEB J., 10: A572, 1996.

428. A-641 Borg-Capra, C., Fournet-Bourguignon, M.P., Janiak, P., Villeneuve, N., Bidouard, J.P.,

Vilaine, J.P., Vanhoutte, P.M. Expression of Gi-proteins in regenerated endothelial cells of the porcine coronary artery. FASEB J., 10: A602, 1996.

429. A-642 Villeneuve, N., Perrault, L.P., Janiak, P., Bidouard, J.P, Vilaine, J.P., Vanhoutte, P.M. G-

protein impairment and endothelial dysfunction during acute rejection after heart transplantation. FASEB J., 10: A809, 1996.

430. A-644 Spedding, M., King, B.F., Dacquet, C., Vanhoutte, P.M., Burnstock, G. Specific

modulation of P2 receptors by 2-2'-pyridylisatogen (PIT). Drug Dev. Res. 37: 174, 1996.

126

431. A-645 Perrault, L.P., Bidouard, J.P., Janiak, P., Villeneuve, N., Vilaine, J.P., Vanhoutte, P.M. G-protein dysfunction in acute and chronic rejection after heart transplantation. European Journal of Clinical Investigation, 2: A3, 1996.

432. A-646 Vanhoutte, P.M. Endothelial dysfunction in cardiovascular disease. International

Angiology, 15: 1, 1996. 433. A-647 Vanhoutte, P.M. Pathophysiology of venous disease. International Angiology, 15 : 1, 1996. 434. A-648 Perrault, L.P., Bidouard, J.P., Janiak, P., Villeneuve, N., Vilaine, J.P., Vanhoutte, P.M. Time

course and specific mechanisms of coronary endothelial dysfunction in acute untreated rejection after heart transplantation. The Journal of Heart and Lung Transplantation, 15: S49 , 1996.

435. A-649 Vanhoutte, P.M. Endothelium-dependent responses in hypertension. From the 16th

Scientific Meeting of the International Society of Hypertension, Glasgow, 23-27 June 1996. 436. Error 437. A-651 Vanhoutte, P.M. Endothelial dysfunction and reperfusion injury. Acta Physiologica

Pharmacologica et Therapeutica Latinamericana, 46: 36, 1996. 438. A-652 Perrault, L.P., Borg-Capra, C., Fournet-Bourguignon, M.P., Bidouard, J.P., Janiak, P.,

Villeneuve, N., Vilaine, J.P., Vanhoutte, P.M. Expression and function of endothelial Gi-proteins in accelerated atherosclerosis after heart transplantation. European Heart Journal, 17: 464 , 1996.

439. A-653 Vanhoutte, P.M. The local kinin-kallikrein system and endothelial control of vascular tone.

International Journal of Microcirculation Clinical and Experimental, 16: 82, 1996. 440. A-654 Perrault, L.P., Menasché P., Wassef, M., Bidouard, J.P., Janiak, P., Villeneuve, N.,

Jacquemin, C., Bloch, G., Vilaine, J.P., Vanhoutte, P.M. Effects on endothelial function of different hemostatic devices during continuous delivery of blood cardioplegia or minimally invasive surgery. Cardiovascular Surgery, 168, 1996.

441. A-656 Perrault, L.P., Bidouard, J.P., Janiak, P., Villeneuve, N., Vilaine, J.P., Vanhoutte, P.M.

Heart transplantation as a model of endothelial dysfunction in coronary atherosclerosis. The Canadian Journal of Cardiology, 12 : 148E, 1996.

442. A-657 Perrault, L.P., Janiak, P., Gransagne, D., Bidouard, J.P., Villeneuve, N., Vilaine, J.P.,

Vanhoutte, P.M. Expression of metalloproteinases in coronary arteries after angioplasty and heart transplantation. The Canadian Journal of Cardiology, 12 : 167E, 1996.

443. A-658 Perrault, L.P., Fournet-Bourguignon, M.P., Bidouard, J.P., Janiak, P., Villeneuve, N.,

Vilaine, J.P., Vanhoutte, P.M. Expression of endothelial Gi-proteins and nitric oxide synthase in accelerated atherosclerosis after heart transplantation. Circulation, 94:I-106, 1996.

444. A-659 Janiak, P., Perrault, L.P., Gransagne D., Bidouard, J.P., Villeneuve, J.P., Vilaine, J.P.,

Vanhoutte, P.M. Expression of matrix metalloproteinases in coronary arteries after balloon denudation and heart transplantation. Circulation, 94: I-586, 1996.

445. A-660 Vanhoutte, P.M. Pathophysiologie de la maladie veineuse. Angéiologie, 49: 82-84, 1997.

127

446. A-662 Perrault, L.P., Bidouard, J.P., Jacquemin, C., Petit, C., Villeneuve, N., Vilaine, J.P.,

Vanhoutte, P.M. The production of cyclic GMP decreases with the coronary endothelial dysfunction after heart transplantation. FASEB J., 11 : A426, 1997.

447. A-663 Castedo-Delrieu, M., Fournet-Bourguignon, M.P., Bidouard, J.P., Delescluse, I., Leonce S.,

Vilaine, J.P., Vanhoutte, P.M. Phenotypic and functional characterization of regenerated endothelial cells after balloon injury in the pig. Journal of Vascular Research, 34 : 1-48, 1997.

448. A-664 Chataigneau, T., Corriu, C., Félétou, M., Canet, E., Duhault, J., Vanhoutte, P.M. Potassium

channels and endothelium-dependent hyperpolarization of the guinea-pig carotid artery. Journal of Vascular Research, 34 : 1-48, 1997.

449. A-665 Chataigneau, T., Thollon, C., Iliou, J.P., Villeneuve, N., Félétou, M., Vilaine, J.P., Duhault,

J., Vanhoutte, P.M. Cannabinoid CB1 receptors and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries. Journal of Vascular Research, 34: 1-48, 1997.

450. A-666 Corriu, C., Félétou, M., Puybasset, L., Berdeaux, A., Vanhoutte, P.M., Endothelium-

dependent hyperpolarizations after chronic treatment with NO-synthase inhibitors. Journal of Vascular Research, 34: 1-48, 1997.

451. A-667 Félétou, M., Corriu, C., Chataigneau, T., Canet, E., Duhault, J., Vanhoutte, P.M.

Endothelium-dependent hyperpolarization of the guinea-pig carotid artery and cytochrome P450-mono-oxygenase. Journal of Vascular Research, 34: 1-48, 1997.

452. A-668 Fournet-Bourguignon, M.P., Bidouard, J.P., Saboureau, D., Delescluse, I., Vanhoutte, P.M.,

Vilaine, J.P. Alteration of nitric oxide pathway in regenerated endothelial cells 28 days after balloon injury of porcine coronary arteries. Journal of Vascular Research, 34: 1-48, 1997.

453. A-669 Nakashima, M., Vanhoutte, P.M. Hyperpolarization and relaxation of canine vascular

smooth muscle to vasoactive intestinal polypeptide. Journal of Vascular Research, 34: 1-48, 1997. 454. A-671 Perrault, L.P., Bidouard J.P., Villeneuve, N., Vilaine, J.P., Vanhoutte, P.M. L-nitro arginine-

resistant relaxations of coronary arteries are impaired after heart transplantation. Journal of Vascular Research, 34: 1-48, 1997.

455. A-672 Perrault, L.P., Villeneuve, N., Bidouard, J.P., Vilaine, J.P., Vanhoutte, P.M. Endothelial

dysfunction and atherosclerosis in the working versus non-working heterotopic transplantic heart. Journal of Vascular Research, 34: 1-48, 1997.

456. A-673 Thollon, C., Bidouard, J.P., Cambarrat, C. Delescluse, I., Vanhoutte, P.M., Vilaine, J.P.

Endothelium-dependent hyperpolarization in porcine coronary arteries with regenerated endothelium: decreased response to serotonin and increased hyperpolarization to bradykinin. Journal of Vascular Research, 34: 1-48, 1997.

457. A-674 Villeneuve, N., Marteau, V., Jacquemin, C., Petit, C., Pillon, A., Vanhoutte, P.M., Vilaine,

J.P. An in vitro model of selective endothelial dysfunction. Journal of Vascular Research, 34: 1-48, 1997.

128

458. A-676 Perrault, L.P., Villeneuve, N., Bidouard, J.P., Vilaine, J.P., Vanhoutte, P.M. Endothelial dysfunction and atherosclerosis in the working versus non-working heterotopic transplanted hearts. The Canadian Journal of Cardiology, 13: 81C, 1997.

459. A-677 Perrault, L.P., Menasché, P., Lisi, G., Bidouard, J.P., Villeneuve, N., Vilaine, J.P.,

Vanhoutte, P.M. Minimally invasive coronary artery bypass surgery and the endothelium. The Canadian Journal of Cardiology, 13: 116C, 1997.

460. A-681 Perrault, L.P., Villeneuve, N., Bidouard, J.P., Vilaine, J.P., Vanhoutte, P.M. Effect of left

ventricular loading on coronary endothelial dysfunction and intimal thickening in a swine model of heterotopic heart transplantation. Circulation, 96(suppl. 8): 3399, 1997.

461. A-682 Perrault, L.P., Bidouard, J.P., Villeneuve, N., Vilaine, J.P., Vanhoutte, P.M. Endothelial

denudation at implantation worsens coronary endothelial dysfunction and intimal thickening after heart transplantation. Circulation, 96: 3749, 1997.

462. A-683 Perrault, L.P., Bidouard, J.P., Villeneuve, N., Vilaine, J.P., Vanhoutte, P.M. Impairment of

L-nitro arginine-resistant vasorelaxations in the endothelial dysfunction after heart transplantation. Circulation, 96: 3751, 1997.

463. A-684 Corriu, C., Félétou, M., Puybasset, L., Berdeaux, A., Vanhoutte, P.M. Endothelium-

dependent hyperpolarizations after chronic in vivo treatment with nitric oxide synthase inhibitors. Br. J. Pharmacol., 122: 205P, 1997.

464. A-685 Chataigneau, T., Félétou, M., Thollon, C., Vilaine, J.P., Duhault, J., Vanhoutte, P.M.

Cannabinoid CB1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries. Br. J. Pharmacol., 122: 249P, 1997.

465. A-686 Félétou, M., Vanhoutte, P.M. EDHF exists. Br. J. Pharmacol. 122 : 441P, 1997. 466. A-687 Villeneuve, N., Perrault, L.P., Bidouard, J.P., Vilaine, J.P., Vanhoutte, P.M. Comparative

study of coronary endothelial dysfunction after heart transplantation in domestic versus microswines. FASEB J., : A481, 1998.

467. A-688 Perrault, L.P., Bidouard, J.P., Villeneuve, N., Vilaine, J.P., Vanhoutte, P.M. Effect of

intracoronary L-Name infusion on endothelial dysfunction and intimal hyperplasia after heart transplantation. FASEB J., : A978, 1998.

468. A-689 Vanhoutte, P.M. Endothelial dysfunction in cardiovascular disease. J. Am. Coll. Cardiol.,

31: 454C, 1998. 469. A-690 Perrault, L.P., Bidouard, J.P., Villeneuve, N., Vilaine, J.P., Vanhoutte, P.M. Effect of

intracoronary L-Name infusion on endothelial dysfunction and intimal hyperplasia after heart transplantation. J. Mol. Cell. Cardiol., 30: A36, 1998.

470. A-691 Vanhoutte, P.M. Endothelial dysfunction : From Physiology to therapy. J. Mol. Cell.

Cardiol., 30: A198, 1998.

129

471. A-703 Cardososo Leão, M., Vayssettes-Courchay, C., Vanhoutte, P.M., Cordi, A.A. and Verbeuren, T.J. LPS-treatment decreases contractility of the rabbit saphenous vein in vivo: implication of NO. Research in Cardiology, 94: 400, 1999.

472. A-704 Fournet-Bourguignon, M.P., Castedo-Delrieu, M., Bidouard, J.P., Leonce, S., Saboureau,

D., Delescluse, I., Vilaine, J.P. and Vanhoutte, P.M. Increased uptake of modified LDL and reduced production of NO in regenerated coronary endothelial cells after balloon injury in the pig. FASEB J., 14: A1375, 2000.

473. A-705 Sansilvestri-Morel, P., Rupin, A., Fabiani, J.B., Verbeuren, T.J. and Vanhoutte, P.M..

Dysregulation of collagen expression in smooth muscle cells derived from human varicose veins. FASEB J., 14 : A1388, 2000.

474. A-706 Villeneuve, N., Iliou, J.P., Jacquemin, C., Lestriez, V., Petit, C., Pillion, A., Vanhoutte, P.M.

and Vilaine, J.P. Hydrogen peroxyde (H202) and vascular reactivity in normal and pathological arteries. FASEB J., 14 : A1454, 2000.

475. A-709 Vanhoutte, P.M. Are there functional Endothelial Adrenoceptors ? Pharmacoloy &

Toxicology, 87: L2, 2000. 476. A-710 Brandes, R.P., Félétou, M., Vanhoutte, P.M., Fleming, I., Busse, R. An EDHF Distinct from

No and PGI2 is a Major Endothelium-Dependent Vasodilator in Resistance Vessels of Wild-Type and Enos knockout Mice. Circulation, 102: 31, 2000.

477. A-711 Vanhoutte, P.M. Endothelium dysfunction in Hypertension. Archivos Venezolanos de

Farmacologia Terapeutica. Suppl.1: 9, 2000. 478. A-712 Vanhoutte, P.M. Endothelium: role in hypertension. Rol del endotelio en la Hipertension.

Archivos Venezolanos de Farmacologia Terapeutica. Suppl.1 : 29, 2000. 479. A-713 Vanhoutte, P.M. Endothelial dysfunction and coronary disease : a novel therapeutic

target. Cardiovascular Drugs and Therapy., 15 : 31, 2001. 480. A-714 Bychkov, R., Félétou, M., Edwards, G., Weston, A., Vanhoutte, P.M. Ca2+-Activated

K+ channels in freshly isolated endothelial cells of porcine coronary artery. J. of Vascular Research, 38: 8, 2001.

481. A-715 Edwards, G., Félétou, M., Thollon, C., Gardener, M.J., Vilaine, J.P., Weston, A.,

Vanhoutte, P.M. EDHF and Gap-Junctions in rat, guinea-pig and porcine arteries. J. of Vascular Research, 38: 11, 2001.

482. A-716 Fournet-Bourguignon, M.P., Thollon, C., Saboureau, D., Brulé, E., Lesage, L.,

Reure, H., Vilaine, J.P. and Vanhoutte, P.M.. Cells from regenerated endothelium loss their anti-thrombogenic properties due to the alteration of NO synthase activity. J. of Vascular Research, 38: 12, 2001.

483. A-717 Sansilvestri-Morel, P., Rupin, A., Fabiani, J.N., Verbeuren, T.J., Vanhoutte, P.M.

Alterations of remodeling of varicose veins can be reproduced in vitro by cultures smooth muscle cells. J. of Vascular Research, 38: 21, 2001.

130

484. A-718 Thollon, C., Fournet-Bourguignon, M.P., Lesage, L., Reure, H., Saboureau, D., Vanhoutte, P.M., Vilaine, J.P. Reduced basal production of nitric oxide in porcine arteries with regenerated endothelium. J. of Vascular Research, 38: 25, 2001.

485. A-719 Villeneuve, N., Fortuno, A., Sauvage, M., Fournier, N., Iliou, J.P., Breugnot, C.,

Jacquemin, C., Petit, C., Briant, C., Lestriez, V., Vanhoutte, P.M., Vilaine, J.P.. Persistence of the nitric oxide pathway in the aorta of hypercholesterolemic apolipoprotein E. deficient mice. J. of vascular Research, 38: 27, 2001.

486. A-720 Weston, A., Félétou, M., Thollon, C., Gardener, M.J., Vilaine, J.P., Vanhoutte, P.M.,

Edwards, G. EDHF and gap junctions in rat, guinea-pig and porcine arteries. J. of vascular Research, 38: 27, 2001.

487. A-721 Vanhoutte, P.M. Endothelium Dysfunction and Coronary Disease : a novel

therapeutic target. Cardiovascular Drugs and Therapy, 15: 31, 2001 488. A-722 Fournier, N., Fortuno, A., Villeneuve, N., Sauvage, M., Iliou, J.P., Carpentier, N.,

Vanhoutte, P.M., Vilaine, J.P. Peristence of the nitric oxide pathway and VEGF-induced angiogenesis in Apolipoprotein-Edeficient mice. Arterioscler Thromb Vasc Biol, 22(5): 183, 2002.

489 A-723 Fortuno, A., Thollon, C., Villeneuve, N., Jacquemin, C., Vanhoutte, P.M., Vilaine,

J.P. Non NO, non-prostanoid dependent hyperpolarization in the aorta of control and apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol, 22(5): 394, 2002.

490 A-724 Fournet-Bourguignon, M.P., Breugnot, C., Fortuno, A., Saboureau, D., Brule, E.,

Villeneuve, N., Vanhoutte, P.M. and Vilaine, J.P. Thrombogenic properties of the endothelium of Apolipopretein-E deficient mice. Arterioscler Thromb Vasc Biol, 22(5): 390, 2002.

491 A-725 Félétou, M., Burnham, M., Bychkov, R., Richards, G.R., Edwards, G., Weston,

A.H., Vanhoutte, P.M. Apamin-sensitive and chartybdotoxin-senstivie samal and intermediate conductance Ca2+-activated K+ channels in porcine coronary endothelium: relevance to EDHF. FASEB J., 880, 2002.

492. A-727 Yang, D., Félétou, M., Levens, N., Zhang, J.N., Vanhoutte, P.M.

Tetrahydrobiopterin potentiates endothelium-dependent contactions to acetylcholine in aortas from spontaneously hypertensive rats. FASEB J., : A1137, 2002.

493. A-728 Yang, D., Félétou, M., Levens, N., Zhang, J.N., Vanhoutte, P.M. Demonstration of a

diffusible endothelium-derived contracting factor in response to acetylcholine. FASEB J, :1137, 2002.

494. A-729 Vanhoutte, P.M. Endothelial dysfunction in cardiovascular disease. Cardiovascular

Drugs and Therapy, 16 (suppl. 1): 5, 2002. 495. A-731 Sansilvestri-Morel, P., Rupin, A., Lembrez, N., Julien, N., Fabiani, J.N., Verbeuren,

T.J., Vanhoutte, P.M. Marimastat restores the production of collagen III by cultured smooth muscle cells derived from human varicose veins. Pharmacologist, 44 : A89, 2002.

496. A-732 Vanhoutte, P.M. Endothelial control of vascular function. Circulation J., 67: I-8, 200

131

497. A-733 Vanhoutte, P.M.. Endothelial Function: from Health to Heart Failure. J HK Coll.

Cardiol., 11 (supp 1):A1, 2003. 498. A-734 Chan, Y.C., Yao, X., Liu, C.L., Vanhoutte, P.M. and Huang, Y. Raloxifene dilates

rat pressurized mesentweric arteries: role of endothelium. J HK Coll. Cardiol., 11 (supp1): A19, 2003.

499. A-735 Leung, H.S., Yao, X., He, G.W., Huang, Y. and Vanhoutte, P.M. The vasorelaxant

Response of Raloxifene in porcine Coronary Arteries. J HK Coll. Cardiol., 11 (supp 1): A20, 2003.

500. A-736 Félétou, M., Burnham, M.P., Bychkov, R., Richards, G.R., Edwards, G., Weston,

A.H., Vanhoutte, P.M.. Apamin-Sensitive and Charybdotoxin-Sensitive Small and Intermediate Conductance Ca2+-Activated K+ Channels in Porcine Coronary Endothelium: Relevance to EDHF. Faseb J. 16(4): A80, 2002.

501. A-737 Yang, D., Félétou, M., Levens, N., Zhang, J-N., Vanhoutte, P.M.

Tetrahydrobiopterin specifically potentiates endothelium-dependent contractions, in response to acetylcholine, in aortas from spontaneously hypertensive rats. Faseb J. 16(5): A1137, 2002.

502. A-738 Yang, D., Félétou, M., Levens, N., Zhang, J-N., Vanhoutte, P.M.. Evidence of

diffusible endothelium-derived contracting factor in response to acetylcholine in the aortas from spontaneously hypertensive rats. Faseb J. 16(5): A1138, 2002.

503. A-739 Yang, D., Félétou, M., Levens, N., Zhang, J-N., Vanhoutte, P.M.. Endothelium-

dependent contractions in the aorta of spontaneously hypertensive rat: involvement of tetrahydrobiopterin-sensitive diffusible substance. Fundam. Clin. Pharmacol. I16(5), A420, 2002.

504. A-740 Yang, D., Félétou, M., Levens, N., Zhang, J-N., Vanhoutte, P.M. A diffusible

substance(s) mediate(s) endothelium-dependent contractions in the aorta of spontaneously hypertensive rat. Br. J. Pharmacol., 136: 7P, 2002.

505. A-741 Vanhoutte, P.M. Historical notes: the other EDRF. Fundam. Clin. Pharmacol. 18(1), S04.1, 2004.

506. A-742 Félétou, M., Vanhoutte, P.M. Actions of EDHF on vascular smooth muscle.

Fundam. Clin. Pharmacol. 18(1), S04.5, 2004. 507. A-743 Félétou, M., Vanhoutte, P.M. The obligatory role of endothelial SKCa and IKCa

channels in EDHF-mediated responses. Acta Pharmacologica Sinica 25(11): 1387-1568, 2004. 508 A-744 Vanhoutte, P.M. Endothelium-dervived Contracting Factor in Health and Disease J HK Coll Cardiol. Vo1 12, IL5 (87), July/October 2004. 509 A745 Shi, Y., Ku, D.D., Man, R.Y.K., Vanhoutte, P.M. Streptozocin-induced Effects on

Endothelium-dependent Responses in Rat Carrotid and Measenteric Arteries J HK Coll Cardiol Vol 12, OC1 (92), July/October 2004.

132

510 A746 Tang, E.H.C., Félétou, M., Huang, Y., Man, R.Y.K., Vanhoutte, P.M. Nitric Oxide Causes Long-term Inhibition of EDCF-mediated Contractions. J HK Coll Cardiol Vol 12, OC8 (95), July/October 2004.

511 A747 Chan, Y.C., Yao, X., Lau, C.W., Vanhoutte, P.M., Huang, Y. Raloxifene Therapy

Improves Basal Nitric Oxide Release in Pulmonary Arteries of Spontaneously Hypertensive Rats. J HK Coll Cardiol Vol 12, P38 (111), July/October 2004.

512 A748 Leung, S.H., Yao, X., Vanhoutte, P.M., Huang, Y. Characterization of

Endothelium-dependent Relaxation in Rat Femoral Arteries. J HK Coll Cardio Vol 12, P39 (111), July/October 2004.

513 A749 Ho, K.W., Chan, Y.C., Wong, K.M., Chan, F.L., Yao, X., Gollasch, M., Vanhoutte,

P.M., Huang, Y. Regulation of Vascular Reactivity by Periadventitial Fat in Rat Small Arteries. J HK Coll Cardio Vol 12, P41 (112), July/October 2004.

514 A750 Ng, C.H., Chen, Z.Y., Yao, X., Au, C.L., Yung, L.M., Wong, C.M., Vanhoutte,

P.M., Huang, Y. Raloxifene Improves Vasorelaxation in Oxidized LDL-treated Rat Aortas. J HK Coll Cardio Vol 12, P43 (113), July/October 2004.

515 A751 Wong, C.M., Yung, L.M., Au, C.L., Yao, X., Leung, F.P., Cheng, H.K., Vanhoutte,

P.M., Huang, Y. Raloxifene Ameliorates Endothelial Dysfunction Induced by Free Radical Exposure. J HK Coll Cardio Vol 12, P42 (113), July/October 2004.

516 A752 Tang, E.H., Ku, D.D., Tipoe, G.L., Félétou, M., Man, R.Y., Vanhoutte, P.M. The

Calcium lonophore A23187 Causes Endothelium-Dependent Contractions in the Aorta of Wild-Type but not COX1-Knockout Mice. Circulation Vol 110 , III-35 (163), October 26, 2004.

517 A753 Vanhoutte, P.M. Endothelial Dysfunction and Vascular Disease. Acta

Pharmacologica Sinica Suppl.1, L13, July 2006. 518 A754 Félétou, M., Vanhoutte, P.M.. Prostacyclin: EDRF, EDHF and EDCF Acta

Pharmacologica Sinica Suppl.1, P080002, July 2006. 519 A755 Tang, E.H.C., Man, R.Y.K., Vanhoutte, P.M. Spontaneous Contractions in the Aorta

of the Spontaneously Hypertensive Rat. Acta Pharmacologica Sinica Suppl.1, P080043, July 2006.

520 A756 Rasmussen, L.E., Vanhoutte, P.M., Jensen, L.B., Skott, O. Continuous luminal flow

attenuates basal relaease of NO but augments that of EDHF in the rabbit carotid artery. Acta Pharmacologica Sinica Suppl.1, P110100, July 2006.

521 A757 Shi, Y., Ku, D.D., Man, R.Y.K., Vanhoutte, P.M. Oxygen-derived free radicals

mediate endothelium-derived contractions in the femoral artery from streptozotocin-treated rats. Acta Pharmacologica Sinica Suppl.1, P110154, July 2006.

522 A758 Lee, M.Y.K., Holmskov, U., Man, R.Y.K., Vanhoutte, P.M. Reduced up regulation

of SP-D in response to TNF-α in senescent endothelial cells. Acta Pharmacologica Sinica Suppl.1, P110158, July 2006.

133

523 A759 Frederic, M., Man, G., Tang, E., Man, R., Vanhoutte, P. Age, hypertension and nitric oxide synthase (NOS) inhibition augment endothelium-derived contracting factor (EDCF) in the rat renal artery. Acta Pharmacologica Sinica Suppl.1, P110182, July 2006.

524 A760 Schjerning, J., Uhrenholt, T.R., Vanhoutte, P.M. Intercellular calcium signaling and

nitric oxide feedback during constriction of rabbit renal arterioles. Acta Pharmacologica Sinica Suppl.1, P360059, July 2006.

525 A761 Vanhoutte, P.M. Endothelial function and coronary disease. Journal of the Hong

Kong College of Cardiology 14(2): IL6, p.70, Oct 2006. 526 A762 Shi, Y., Ku, D.D., Man, R.Y.K., Vanhoutte, P.M. Oxygen-derived free radicals

mediate endothelium-dependent contractions in the femoral artery from streptozotocin-treated rats. Journal of the Hong Kong College of Cardiology 14(2): OC3, p.74, Oct 2006.

527 A763 Tang, E.H.C., Man, R.Y.K., Vanhoutte, P.M. Celular changes in aortas of

spontaneously hypertensive rats facilitate the occurrence of endothelium-dependent contractions. Journal of the Hong Kong College of Cardiology 14(2): P13, p.83, Oct 2006.

528 A764 Xu, Y.C., Leung, S.W.S., Leung, G.P.H., Vanhoutte, P.M. Kaempferol potentiated

relaxation in porcine coronary arteries and stimulated large-conductance potassium channes in HUVEC. Journal of the Hong Kong College of Cardiology 14(2): P19, p.85, Oct 2006.

529 A765 Yung, L.M., Leung, F.P., Wong W.T., Lau, C.W., Yao, X.Q., Chen, Z.Y.,

Vanhoutte, P.M., Huang, Y. Cranberry juice consumption prevents endothelial dysfunction in ovariectomized rats. Journal of the Hong Kong College of Cardiology 14(2): P20, Oct 2006.

530 A766 Wang, Y., Huang, Y., Lam, K.S.L., Lau, C.W., Vanhoutte, P.M., Xu, A. Berberine

as a potential drug for the treatment and prevention of vascular dysfunction in obesity and diabetes. Journal of the Hong Kong College of Cardiology 16(2): IL 11, Oct 2008.

540 A767 Chan, C.K.Y., Mak, J., Man, R.Y.K., Vanhoutte, P.M. Contractile response to

hypoxia in the porcine coronary artery. Journal of the Hong Kong College of Cardiology 16(2): OC1, Oct 2008.

541 A768 Lee, M.Y.K., Vanhoutte, P.M., Xu, A Adipocyte-fatty acid binding protein (A-

FABP) is present in the endothelium of male apolipoprotein e-knockout mice. Journal of the Hong Kong College of Cardiology 16(2): IL 11, Oct 2008.

542 A769 Kong, B.W.C., Leung, S.W.S., Man, R.Y.K., Vanhoutte, P.M. The effect of aging

and hypertension on endothelial-derived hyperpolarizing factor (EDHF)-mediated responses in spontaneously hypertensive rats. Journal of the Hong Kong College of Cardiology 16(2): P4, Oct 2008.

543 A770 Leung, I.C.Y., Vanhoutte, P.M., Man, R.Y.K., Leung, G.P.H. Tissue-type

plasminogen activator: a possible candidate of endothelium-derived hyperpolarization factor? Journal of the Hong Kong College of Cardiology 16(2): P5, Oct 2008.

134

544 A771 Liang, C.F., Leung, S.W.S., Ng, J.K.F., Man, R.Y.K., Vanhoutte, P.M. Inhibition of the relaxation to CNP by endothelium-derived nitric oxide in the porcine coronary artery. Journal of the Hong Kong College of Cardiology 16(2): P6, Oct 2008.

545 A772 Wong, E.S.W., Man, R.Y.K., Vanhoutte, P.M., Ng, K.F.J. Effects of

dexmedetomidine in the mesenteric artery and the aorta of endotoxin induced rat. Journal of the Hong Kong College of Cardiology 16(2): P10, Oct 2008.

546 A773 Wong, M.S.K., Man, R.Y.K., Vanhoutte, P.M. Calcium-independent phospholipase

A2 involves in endothelium-dependent contractions in the aorta of the spontaneously hupertensive rats. Journal of the Hong Kong College of Cardiology 16(2): P9, Oct 2008.

547 A774 Leung, G.P.H., Li, R.W.S., Seta, S.W., Kwan, Y.W. Inhibitory effects of non-

steroidal anti-inflammatory drugs (NSAIDS) on nucleoside transporters in human aortic smooth muscle cells. Journal of the Hong Kong College of Cardiology 16(2): P21, Oct 2008.

548 A775 Vanhoutte, P.M. Nitric Oxide, the gatekeeper of endothelial function. Nitric Oxide,

22(Suppl): O1, 2010. 549 A776 Vanhoutte, P.M. Converting enzyme inhibitors and endothelial dysfunction. Nitric

Oxide, 22(Suppl):O106, 2010. 550 A777 Liang, C.F., Xu, A., Vanhoutte, P.M. Loss-of-function in toll-like receptor 4

receptors nitric oxide-mediated relaxations in LEPRdb/db mice. Journal of the Hong Kong College of Cardiology 18(2): OC1, Oct 2010.

551 A778 Li, Z., Vanhoutte, P.M. Up-regulation of heme oxygenase-1 improves endothelial

functions by impairing endothelium-dependent contractions and enhancing endothelium-dependent hyperpolarizations. Journal of the Hong Kong College of Cardiology 19(2): OC8, Oct 2010.

552 A779 Zhao, Y.Z., Leung, S.W.S., Vanhoutte, P.M. Endothelial NOS-independent release

of nitric oxide in the aorta of the spontaneously hypertensive rat. Journal of Hong Kong College of Cardiology 19(2): P11, Oct 2010.

553 A780 Zou, Q., Vanhoutte, P.M. Activation of nicotinic receptors contributes to

acetylcholine-induced endothelium-dependent relaxations in the aorta of the spontandous hypertensive rat. Journal of Hong Kong College of Cardiology 19(2): P12, Oct 2010.

554 A781 Sit, A.S.M., Ho, E.Y.W., Li, R.W.S., Man, R.Y.K., Kwan, Y.W., Hausman, M.,

Vanhoutte, P.M., Leung, G.P.H. Ergothioneine protects endothelial cells from oxidative stress. Journal of Hong Kong College of Cardiology 19(2): P22, Oct 2010.